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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRKAB2 Gene

protein-coding   GIFtS: 68
GCID: GC01M146627

Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit1 2
AMPK Beta 21 2
AMPK Subunit Beta-22 3
5'-AMP-Activated Protein Kinase Subunit Beta-22
5'-AMP-Activated Protein Kinase, Beta-2 Subunit2
AMPK Beta-2 Chain2

External Ids:    HGNC: 93791   Entrez Gene: 55652   Ensembl: ENSG000001317917   OMIM: 6027415   UniProtKB: O437413   

Export aliases for PRKAB2 gene to outside databases

Previous GC identifers: GC01M144845 GC01M143356 GC01M143971 GC01M144138 GC01M144133 GC01M143851 GC01M145093 GC01M120041


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKAB2 Gene:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a
heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an
important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses,
AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy
beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid
and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal
muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been
found for this gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for PRKAB2 Gene: 
PRKAB2 (protein kinase, AMP-activated, beta 2 non-catalytic subunit) is a protein-coding gene. Diseases associated with PRKAB2 include cellulitis, and lafora disease, and among its related super-pathways are Energy dependent regulation of mTOR by LKB1-AMPK and Insulin receptor signalling cascade. GO annotations related to this gene include AMP-activated protein kinase activity and identical protein binding. An important paralog of this gene is PRKAB1.

UniProtKB/Swiss-Prot: AAKB2_HUMAN, O43741
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays
a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK
activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic
enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of
cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta
non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges
alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

Gene Wiki entry for PRKAB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167185.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRKAB2 gene promoter:
         GR   Spz1   AML1a   Lmo2   GATA-1   MEF-2A   ZIC2/Zic2   GR-alpha   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRKAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.2

PRKAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAB2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M146627:  view genomic region     (about GC identifiers)

Start:
146,626,685 bp from pter      End:
146,644,129 bp from pter
Size:
17,445 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AAKB2_HUMAN, O43741 (See protein sequence)
Recommended Name: 5'-AMP-activated protein kinase subunit beta-2  
Size: 272 amino acids; 30302 Da
Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a
gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3)
6/10 PDB 3D structures from and Proteopedia for PRKAB2 (see all 10):
2F15 (3D)        2V8Q (3D)        2V92 (3D)        2V9J (3D)        2Y8L (3D)        2Y8Q (3D)    
Secondary accessions: A8K9V5 Q5VXY0

Explore the universe of human proteins at neXtProt for PRKAB2: NX_O43741

Explore proteomics data for PRKAB2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2;
    leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between
    ULK1, ULK2 and AMPK
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43741

  • PRKAB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRKAB2 Protein Expression
    REFSEQ proteins: NP_005390.1  
    ENSEMBL proteins: 
     ENSP00000254101   ENSP00000415469  
    Reactome Protein details: O43741
    Human Recombinant Protein Products for PRKAB2: 
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    ProSpec Recombinant Protein for PRKAB2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0031588AMP-activated protein kinase complex IDA17851531

    PRKAB2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, AMP-activated, beta 2 non-catalytic subunit 
    AMPK subfamily
    Selected non-AGC protein kinase activities

    1 InterPro protein domain:
     IPR006828 AMP_prot_kin_bsu_interact-dom

    Graphical View of Domain Structure for InterPro Entry O43741

    ProtoNet protein and cluster: O43741

    1 Blocks protein domain: IPB006828 5-AMP-activated protein kinase

    UniProtKB/Swiss-Prot: AAKB2_HUMAN, O43741
    Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family


    PRKAB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAKB2_HUMAN, O43741
    Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays
    a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK
    activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
    lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic
    enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of
    cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta
    non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges
    alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

         Genatlas biochemistry entry for PRKAB2:
    protein kinase,cAMP activated,beta 2 non catalytic subunit,highly expressed in skeletal and cardiac
    muscle,complexing with alpha 2 and gamma 1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004679contributes to AMP-activated protein kinase activity IDA--
    GO:0005515protein binding IPI16306228
    GO:0016301kinase activity ----
    GO:0042802identical protein binding IPI--
         
    PRKAB2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkab2):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle 

    PRKAB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prkab2tm1.1Grst for PRKAB2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRKAB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRKAB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKAB2 
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    SwitchGear 3'UTR luciferase reporter plasmidPRKAB2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRKAB2 About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Energy dependent regulation of mTOR by LKB1-AMPK
    Energy dependent regulation of mTOR by LKB1-AMPK0.82
    PKB-mediated events0.61
    Regulation of AMPK activity via LKB10.82
    Regulation of Rheb GTPase activity by AMPK0.59
    mTOR signalling0.63
    TOR signaling0.33
    2IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    3Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    4Membrane Trafficking
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    5Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PRKAB2
        Development Leptin signaling via PI3K-dependent pathway

    1 R&D Systems Pathway for PRKAB2
        Adipocytokines & Insulin Signaling

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAB2
        AMPK Enzyme Complex Pathway
    eNOS Signaling
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for PRKAB2
        Glucose / Energy Metabolism

    1 Tocris Bioscience Pathway for PRKAB2
        mTOR Pathway

    2 GeneGo (Thomson Reuters) Pathways for PRKAB2
        Regulation of CFTR activity (norm and CF)
    Development Leptin signaling via PI3K-dependent pathway

    3 BioSystems Pathways for PRKAB2
        TOR signaling
    AMPK signaling
    Energy Metabolism


    5/22        Reactome Pathways for PRKAB2 (see all 22)
        Membrane Trafficking
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    IRS-related events
    IRS-mediated signalling

    1 PharmGKB Pathway for PRKAB2
        Metformin Pathway, Pharmacodynamic

    5         Kegg Pathways  (Kegg details for PRKAB2):
        Circadian rhythm
    Insulin signaling pathway
    Adipocytokine signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)
    Hypertrophic cardiomyopathy (HCM)


    PRKAB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/570 Interacting proteins for PRKAB2 (O437411, 3 ENSP000002541014) via UniProtKB, MINT, STRING, and/or I2D (see all 570)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006853carnitine shuttle TAS--
    GO:0007050cell cycle arrest TAS--
    GO:0007165signal transduction TAS9575201

    PRKAB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for PRKAB2:
    Small Molecule - inhibitor
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    1 DrugBank Compound for PRKAB2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetactivator17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about PRKAB2 / AAKB2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRKAB2 gene: 
    NM_005399.4  

    Unigene Cluster for PRKAB2:

    Protein kinase, AMP-activated, beta 2 non-catalytic subunit
    Hs.50732  [show with all ESTs]
    Unigene Representative Sequence: NM_005399
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254101(uc001epe.3 uc010ozm.2 uc010ozn.2 uc009wjf.1)
    ENST00000496858 ENST00000474939 ENST00000425272
    miRNA
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    Additional mRNA sequence: 

    AJ224538.1 AK023717.1 AK292820.1 AK294863.1 AK304069.1 AK310982.1 AK316005.1 AK316183.1 
    BC053610.1 

    4 DOTS entries:

    DT.455144  DT.65287847  DT.100789728  DT.100789732 

    24/175 AceView cDNA sequences (see all 175):

    AI621036 NM_005399 BX099154 BF593384 BM724633 BQ772256 AI167562 AI026131 
    CA389225 BM975805 CA311731 AV719265 N78576 BF055989 D17070 BI490916 
    CB111633 AA649535 AI583189 BM980118 BU631766 BG120550 BU619639 AI651077 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                                                  -                     
    SP2:              -                                   -                     
    SP3:              -                                                         
    SP4:                                                                        


    ECgene alternative splicing isoforms for PRKAB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRKAB2 expression in normal human tissues (normalized intensities)      PRKAB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTGGTA
    PRKAB2 Expression
    About this image


    PRKAB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Skeletal Muscle (Muscoskeletal System)

    See PRKAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRKAB2

    SOURCE GeneReport for Unigene cluster: Hs.50732
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAB2: 
              mTOR Signaling in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Cardiotoxicity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKAB2 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkab21 , 5 protein kinase, AMP-activated, beta 2 non-catalytic more1, 5 91.27(n)1
    97.42(a)1
      3 (42.25 cM)5
    1080971  NM_182997.21  NP_892042.21 
     976581935 
    chicken
    (Gallus gallus)
    Aves PRKAB21 protein kinase, AMP-activated, beta 2 non-catalytic more 79.53(n)
    90.44(a)
      427017  NM_001044662.1  NP_001038127.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAB26
    Uncharacterized protein
    86(a)
    1 ↔ 1
    4(73746163-73752519)
    African clawed frog
    (Xenopus laevis)
    Amphibia prkab2-prov2 protein kinase, AMP-activated, beta 2 non-catalytic more 75.06(n)    BC053787.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkab21 protein kinase, AMP-activated, beta 2 non-catalytic more 71.72(n)
    76.89(a)
      100170795  NM_001130633.1  NP_001124105.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80573 SNF1A/AMP-activated protein kinase 58(a)   45A11   --
    worm
    (Caenorhabditis elegans)
    Secernentea F55F3.13
    aakb-11
    Protein AAKB-11 50(a)
    (best of 2)3
    53.68(n)1
    54.87(a)1
      X(13791061-13793948)3
    1814921  NM_077897.51  NP_510298.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIP2(YGL208W)4
    SIP21
    One of three beta subunits of the Snf1 serine/threonine more4
    Sip2p1
    49.57(n)1
    41.03(a)1
      7(97338-98585)4
    8526641, 4  NP_011307.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AKINBETA11 SNF1-related protein kinase regulatory subunit beta-1 47.88(n)
    34.52(a)
      832243  NM_122124.3  NP_197615.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04912001 hypothetical protein 49.07(n)
    39.09(a)
      4339173  NM_001062443.1  NP_001055908.1 


    ENSEMBL Gene Tree for PRKAB2 (if available)
    TreeFam Gene Tree for PRKAB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRKAB2 gene
    PRKAB12  
    1 SIMAP similar gene for PRKAB2 using alignment to 2 protein entries:     AAKB2_HUMAN (see all proteins):
    PRKAB1

    PRKAB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/65 SNPs in PRKAB2 are shown (see all 65)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1144753181,2
    C,F--146626404(+) GGGATG/AAGAAT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs66785881,2
    C,F,H--146626483(+) CTGAAA/CATCAA 1 -- ds500118Minor allele frequency- C:0.07NS EA NA WA CSA 2032
    rs1394403591,2
    --146626484(+) TGAAAA/GTCAAA 1 -- ds50010--------
    rs1416393071,2
    C--146626524(+) CATAGC/TCTGAA 1 -- ds50010--------
    rs1831274611,2
    --146626748(+) ATGTAC/TCATAT 1 -- ut310--------
    rs1462034241,2
    C--146626803(+) TGAAGA/GACAGC 1 -- ut310--------
    rs1139597711,2
    C--146626823(+) CACTC-/TTGTCTG 1 -- ut311Minor allele frequency- TT:0.00CSA 2
    rs1886126341,2
    --146626890(+) AAAAAA/GCACCA 1 -- ut310--------
    rs69371,2
    C,F,A,H--146626922(-) AAGGGA/GATTAA 1 -- ut3126Minor allele frequency- G:0.40MN EA NA NS WA 4488
    rs1397087561,2
    --146626940(+) GTCTTA/CTCTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRKAB2 (146626685 - 146644129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PRKAB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv437047CNV Loss16327808
    nsv872257CNV Gain21882294
    nsv8169CNV Gain18304495
    nsv872255CNV Gain21882294
    nsv872251CNV Gain21882294
    esv529CNV CNV17122850
    dgv114e1CNV Complex17122850
    nsv7181OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602741    OMIM disorders: --

    12 diseases for PRKAB2:    About MalaCards
    cellulitis    lafora disease    atrioventricular septal defect    hypertrophic cardiomyopathy
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    diabetes mellitus    myopathy
    atherosclerosis    hepatocellular carcinoma    thyroiditis    gastric cancer

    1 disease from the University of Copenhagen DISEASES database for PRKAB2:
    Atrioventricular septal defect

    PRKAB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRKAB2
    Human Genome Epidemiology (HuGE) Navigator: PRKAB2 (11 documents)

    Export disorders for PRKAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRKAB2 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with PRKAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. (PubMed id 12490143)1, 2, 4, 9 Prochazka M.... Bogardus C. (2002)
    2. Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. (PubMed id 16505254)1, 4, 9 Sun M.W....Florez J.C. (2006)
    3. Common variants in 40 genes assessed for diabetes inc idence and response to metformin and lifestyle intervention in the diabetes pre vention program. (PubMed id 20682687)1, 4 Jablonski K.A....Florez J.C. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (2009)
    6. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. (2009)
    7. Structural basis for AMP binding to mammalian AMP-activated protein kinase. (PubMed id 17851531)1, 2 Xiao B....Gamblin S.J. (2007)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5565 HGNC: 9379 AceView: PRKAB2 Ensembl:ENSG00000131791 euGenes: HUgn5565
    ECgene: PRKAB2 Kegg: 5565 H-InvDB: PRKAB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRKAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRKAB2 gene:
    Search GeneIP for patents involving PRKAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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