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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRKAB2 Gene

protein-coding GIFtS: 67
GCID: GC01M146627

protein kinase, AMP-activated, beta 2 non-catalytic subunit

Explore 12 diseases affiliated with
PRKAB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Kinase, AMP-Activated, Beta 2 Non-Catalytic Subunit¹ ²
AMPK Subunit Beta-2² ³
5'-AMP-Activated Protein Kinase Subunit Beta-2²
5'-AMP-Activated Protein Kinase, Beta-2 Subunit²
AMPK Beta 2²
AMPK Beta-2 Chain²

External Ids:	HGNC: 9379¹	Entrez Gene: 5565²	Ensembl: ENSG00000131791⁷	OMIM: 602741⁵	UniProtKB: O43741³

Export aliases for PRKAB2 gene to outside databases

Previous GC identifers: GC01M144845 GC01M143356 GC01M143971 GC01M144138 GC01M144133 GC01M143851 GC01M145093 GC01M120041

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRKAB2:

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a

heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important

energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is

activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy

beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and

cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and

thus may have tissue-specific roles. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AAKB2_HUMAN, O43741

Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a

key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK

activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid

biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and

by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity

by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a

scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma

subunits (PRKAG1, PRKAG2 or PRKAG3)

Gene Wiki entry for PRKAB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167185.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRKAB2 gene promoter:
GR Spz1 AML1a Lmo2 GATA-1 MEF-2A ZIC2/Zic2 GR-alpha aMEF-2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRKAB2 promoter sequence

Search SABiosciences Chromatin IP Primers for PRKAB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.2

PRKAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAB2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M146627: view genomic region (about GC identifiers)

Start:	146,626,685 bp from pter	End:	146,644,129 bp from pter
Size:	17,445 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AAKB2_HUMAN, O43741 (See protein sequence)

Recommended Name: 5'-AMP-activated protein kinase subunit beta-2

Size: 272 amino acids; 30302 Da

Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma

non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3)

6/10 PDB 3D structures from and Proteopedia for PRKAB2 (see all 10):

2F15 (3D)

2V8Q (3D)

2V92 (3D)

2V9J (3D)

2Y8L (3D)

2Y8Q (3D)

Secondary accessions: A8K9V5 Q5VXY0

Explore the universe of human proteins at neXtProt for PRKAB2: NX_O43741

Post-translational modifications:

Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading

to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and

AMPK¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43741

PRKAB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005390.1

ENSEMBL proteins:

ENSP00000254101 ENSP00000415469

Reactome Protein details: O43741
Human Recombinant Protein Products for PRKAB2:

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	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005952	cAMP-dependent protein kinase complex	--	--
GO:0016324	apical plasma membrane	--	--

PRKAB2 for ontologies About GeneDecksing

PRKAB2 Antibody Products:

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Assay Products for PRKAB2:

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	GenScript PRKAB2-Activity-based Kinase Assay for Compound Screening
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRKAB2 for domains About GeneDecksing

1 InterPro domain/family:

IPR006828 AMP_prot_kin_bsu_interact-dom

Graphical View of Domain Structure for InterPro Entry O43741

ProtoNet protein and cluster: O43741

1 Blocks protein family: IPB006828 5-AMP-activated protein kinase

UniProtKB/Swiss-Prot: AAKB2_HUMAN, O43741

Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AAKB2_HUMAN, O43741

Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a

key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK

activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid

biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and

by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity

by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a

scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma

subunits (PRKAG1, PRKAG2 or PRKAG3)

Genatlas biochemistry entry for PRKAB2:

protein kinase,cAMP activated,beta 2 non catalytic subunit,highly expressed in skeletal and cardiac muscle,complexing

with alpha 2 and gamma 1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004679	contributes to AMP-activated protein kinase activity	IDA	--
GO:0005515	protein binding	IPI	--
GO:0016301	kinase activity	--	--
GO:0019901	protein kinase binding	--	--
GO:0042802	identical protein binding	IPI	--

PRKAB2 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Prkab2):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	liver/biliary system
mortality/aging	muscle

PRKAB2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Prkab2^tm1.1Grst for PRKAB2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRKAB2

miRNA Products:		OriGene 3'-UTR Clone: PRKAB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRKAB2
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAB2 (see all 76):
		hsa-miR-607 hsa-miR-3152-3p hsa-miR-15a hsa-miR-605 hsa-miR-138-2* hsa-miR-3921 hsa-miR-1273d hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: PRKAB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRKAB2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAB2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

Development_Leptin signaling via PI3K-dependent pathway

	Development_Leptin signaling via PI3K-dependent pathway	1.00			Adipocytokine signaling pathway	0.29
	Development Leptin signaling via PI3K-dependent pathway	1.00

Energy dependent regulation of mTOR by LKB1-AMPK

	Energy dependent regulation of mTOR by LKB1-AMPK	1.00			Regulation of Rheb GTPase activity by AMPK	0.59
	Regulation of AMPK activity via LKB1	0.82

mTOR signalling

	mTOR signalling	1.00			TOR signaling	0.33
	PKB-mediated events	0.96

Membrane Trafficking

Membrane Trafficking

1.00

Translocation of GLUT4 to the Plasma Membrane

0.32

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PRKAB2

Development Leptin signaling via PI3K-dependent pathway

1 R&D Systems Pathway for PRKAB2

Adipocytokines & Insulin Signaling

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAB2

	AMPK Enzyme Complex Pathway
	eNOS Signaling
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for PRKAB2

Glucose / Energy Metabolism

1 Tocris Bioscience Pathway for PRKAB2

mTOR Pathway

2 GeneGo (Thomson Reuters) Pathways for PRKAB2

	Regulation of CFTR activity (norm and CF)
	Development Leptin signaling via PI3K-dependent pathway

3 BioSystems Pathways for PRKAB2

	AMPK signaling
	TOR signaling
	Energy Metabolism

5/22 Reactome Pathways for PRKAB2 (see all 22)

	Membrane Trafficking
	Metabolism
	Fatty acid, triacylglycerol, and ketone body metabolism
	IRS-related events
	IRS-mediated signalling

1 PharmGKB Pathway for PRKAB2

Metformin Pathway, Pharmacodynamic

3 Kegg Pathways (Kegg details for PRKAB2):

	Insulin signaling pathway
	Adipocytokine signaling pathway
	Hypertrophic cardiomyopathy (HCM)

PRKAB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRKAB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/538 Interacting proteins for PRKAB2 (O43741^{1, 3} ENSP00000254101⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 538)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL9	P32969³	I2D: score=1
RPL9P7	P32969³	I2D: score=1
RPL9P8	P32969³	I2D: score=1
RPL9P9	P32969³	I2D: score=1
PRKAG1	P54619¹^,³, ENSP00000323867⁴	EBI-1053424,EBI-1181439 I2D: score=5 STRING: ENSP00000323867

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0006853	carnitine shuttle	TAS	--
GO:0007050	cell cycle arrest	TAS	--
GO:0007165	signal transduction	TAS	9575201

PRKAB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for PRKAB2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for PRKAB2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Dorsomorphin dihydrochloride	Potent and selective AMPK inhibitor	[1219168-18-9]
Metformin hydrochloride	Activator of LKB1/AMPK; antidiabetic agent	[1115-70-4]
SAMS Peptide	AMP-activated protein kinase substrate	[125911-68-4]
AICAR	AMPK activator	[2627-69-2]
PT 1	AMPK activator	[331002-70-1]

1 DrugBank Compound for PRKAB2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Adenosine monophosphate	5'-Adenosine monophosphate (see all 15)	61-19-8	target	activator	17139284 17016423

Search CenterWatch for drugs/clinical trials and news about PRKAB2 / AAKB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRKAB2 gene:

NM_005399.3

Unigene Cluster for PRKAB2:

Protein kinase, AMP-activated, beta 2 non-catalytic subunit

Hs.50732 [show with all ESTs]

Unigene Representative Sequence: NM_005399

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000254101(uc001epe.3 uc010ozm.2 uc010ozn.2 uc009wjf.1)

ENST00000496858 ENST00000474939 ENST00000425272

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		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PRKAB2 (see all 76):
		hsa-miR-607 hsa-miR-3152-3p hsa-miR-15a hsa-miR-605 hsa-miR-138-2* hsa-miR-3921 hsa-miR-1273d hsa-miR-298

		SwitchGear 3'UTR luciferase reporter plasmid: PRKAB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PRKAB2

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Additional cDNA sequence:

AJ224538.1 AK023717.1 AK292820.1 AK294863.1 AK304069.1 AK310982.1 AK316005.1 AK316183.1

BC053610.1

4 DOTS entries:

DT.455144 DT.65287847 DT.100789732 DT.100789728

24/175 AceView cDNA sequences (see all 175):

BG120550 BX099154 CB111633 AI167562 AA535114 BF055989 AW079116 BU619639

AI797698 AI203557 BQ775446 D17070 BM975805 BQ772256 AI638769 BU631766

CB145618 AI651077 AI621036 BI490916 CR591350 N78576 BM980118 BF593384

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	·	10c
SP1:																	-
SP2:					-												-
SP3:					-
SP4:

ECgene alternative splicing isoforms for PRKAB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRKAB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTTGGTA

About this image

PRKAB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRKAB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKAB2

SOURCE GeneReport for Unigene cluster: Hs.50732

SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAB2:

mTOR Signaling in human mouse rat

Fatty Acid Metabolism in human mouse rat

Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

Cardiotoxicity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAB2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAB2 gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRKAB2¹	protein kinase, AMP-activated, beta 2 non-catalytic more	79.53(n) 90.44(a)		427017 NM_001044662.1 NP_001038127.1
lizard (Anolis carolinensis)	Reptilia	PRKAB2⁶	--	86(a)	1 ↔ 1	4(73746163-73752505)
African clawed frog (Xenopus laevis)	Amphibia	prkab2-prov²	protein kinase, AMP-activated, beta 2 non-catalytic more	75.06(n)		BC053787.1
zebrafish (Danio rerio)	Actinopterygii	prkab2¹	protein kinase, AMP-activated, beta 2 non-catalytic more	71.72(n) 76.89(a)		100170795 NM_001130633.1 NP_001124105.1
fruit fly (Drosophila melanogaster)	Insecta	CG8057³	SNF1A/AMP-activated protein kinase	58(a)		45A11 --
worm (Caenorhabditis elegans)	Secernentea	F55F3.1³ aakb-1¹	Protein AAKB-1¹	50(a) (best of 2)³ 53.68(n)¹ 54.87(a)¹		X(13791061-13793948)³ 181492¹ NM_077897.5¹ NP_510298.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SIP2(YGL208W)⁴ SIP2¹	One of three beta subunits of the Snf1 serine/threonine more⁴ Sip2p¹	49.57(n)¹ 41.03(a)¹		7(97338-98585)⁴ 852664^{1, 4} NP_011307.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AKINBETA1¹	SNF1-related protein kinase regulatory subunit beta-1	47.88(n) 34.52(a)		832243 NM_122124.3 NP_197615.1
rice (Oryza sativa)	Liliopsida	Os05g0491200¹	hypothetical protein	49.07(n) 39.09(a)		4339173 NM_001062443.1 NP_001055908.1

ENSEMBL Gene Tree for PRKAB2 (if available)
TreeFam Gene Tree for PRKAB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRKAB2 gene

PRKAB1²

1 SIMAP similar gene for PRKAB2 using alignment to 2 protein entries: AAKB2_HUMAN (see all proteins):

PRKAB1

PRKAB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114475318^1,2	C,F	--	146626404(+)	`GGGATG/AAGAAT`	1	--	ds500¹		1		WA	118
rs6678588^1,2	C,F,H	--	146626483(+)	`CTGAAA/CATCAA`	1	--	ds500¹		18		NS EA NA WA CSA	2032
rs139440359^1,2		--	146626484(+)	`TGAAAA/GTCAAA`	1	--	ds500¹		0	--	--	--	--
rs141639307^1,2		--	146626524(+)	`CATAGC/TCTGAA`	1	--	ds500¹		0	--	--	--	--
rs183127461^1,2		--	146626748(+)	`ATGTAC/TCATAT`	1	--	ut3¹		0	--	--	--	--
rs146203424^1,2		--	146626803(+)	`TGAAGA/GACAGC`	1	--	ut3¹		0	--	--	--	--
rs113959771^1,2	C	--	146626823(+)	`CACTC-/TTGTCTG`	1	--	ut3¹		1		CSA	2
rs188612634^1,2		--	146626890(+)	`AAAAAA/GCACCA`	1	--	ut3¹		0	--	--	--	--
rs6937^1,2	C,F,A,H	--	146626922(-)	`AAGGGA/GATTAA`	1	--	ut3¹		26		MN EA NA NS WA	4488
rs139708756^1,2		--	146626940(+)	`GTCTTA/CTCTCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PRKAB2 (146626685 - 146644129 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PRKAB2
     1 CNV: 3312
     1 Indel: 33208
     1 Inversion: 29494

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRKAB2 for disorders           About GeneDecksing

OMIM gene information: 602741    OMIM disorders: --

12 diseases for PRKAB2:    About MalaCards

atrioventricular septal defect type 2 diabetes mellitus lafora disease diabetes mellitus

intrahepatic cholangiocarcinoma cellulitis cholesterol cholangiocarcinoma

hepatocellular carcinoma atherosclerosis thyroiditis carcinoma

1 disease from the University of Copenhagen DISEASES database for PRKAB2:

Atrioventricular septal defect

Genetic Association Database (GAD): PRKAB2
Human Genome Epidemiology (HuGE) Navigator: PRKAB2 (11 documents)

Export disorders for PRKAB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRKAB2 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with PRKAB2)

Utopia: connect your pdf to the dynamic
world of online information

Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians. (PubMed id 12490143)^{1, 2, 4, 9} Prochazka M.... Bogardus C. (2002)
Haplotype structures and large-scale association testing of the 5' AMP-activated protein kinase genes PRKAA2, PRKAB1, and PRKAB2 [corrected] with type 2 diabetes. (PubMed id 16505254)^{1, 4, 9} Sun M.W....Florez J.C. (2006)
Structural basis for AMP binding to mammalian AMP-activated protein kinase. (PubMed id 17851531)^{1, 2} Xiao B....Gamblin S.J. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle. (PubMed id 9575201)^{1, 2} Thornton C.... Carling D. (1998)
Mammalian AMP-activated protein kinase subfamily. (PubMed id 8557660)^{1, 3} Stapleton D.... Kemp B.E. (1996)
Association study between variants of AMP-activated pr otein kinase catalytic and regulatory subunit genes with antipsychotic-induced w eight gain. (PubMed id 22305490)¹ Souza R.P....Muller D.J. (2012)
AMP-activated protein kinase regulation and biological actions in the heart. (PubMed id 22935535)¹ Zaha V.G. and Young L.H. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5565	HGNC: 9379	AceView: PRKAB2	Ensembl:ENSG00000131791	euGenes: HUgn5565
ECgene: PRKAB2	Kegg: 5565	H-InvDB: PRKAB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRKAB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PRKAB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PRKAB2 gene:
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GeneCards and IP:
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protein kinase, AMP-activated, beta 2 non-catalytic subunit

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PRKAB2 Gene

protein kinase, AMP-activated, beta 2 non-catalytic subunit

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