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Aliases for PRKAB1 Gene

Aliases for PRKAB1 Gene

  • Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1 2 3
  • Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit 2 3 5
  • AMPK Subunit Beta-1 3 4
  • AMPK Beta 1 2 3
  • AMPKb 3 4
  • AMPK 3 4
  • Protein Kinase, AMP-Activated, Noncatalytic, Beta-1 3
  • 5-AMP-Activated Protein Kinase Beta-1 Subunit 3
  • AMP-Activated Protein Kinase Beta Subunit 3
  • AMPK Beta -1 Chain 3
  • HAMPKb 3

External Ids for PRKAB1 Gene

Previous GeneCards Identifiers for PRKAB1 Gene

  • GC12P118978
  • GC12P119888
  • GC12P118517
  • GC12P118568
  • GC12P120105
  • GC12P117113

Summaries for PRKAB1 Gene

Entrez Gene Summary for PRKAB1 Gene

  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAB1 Gene

PRKAB1 (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1) is a Protein Coding gene. Diseases associated with PRKAB1 include liver disease and diabetes mellitus, noninsulin-dependent. Among its related pathways are Adipocytokine signaling pathway and AMPK signaling pathway. GO annotations related to this gene include protein kinase activity and AMP-activated protein kinase activity. An important paralog of this gene is PRKAB2.

UniProtKB/Swiss-Prot for PRKAB1 Gene

  • Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Tocris Summary for PRKAB1 Gene

  • AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.

Gene Wiki entry for PRKAB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAB1 Gene

Genomics for PRKAB1 Gene

Regulatory Elements for PRKAB1 Gene

Enhancers for PRKAB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRKAB1 on UCSC Golden Path with GeneCards custom track

Promoters for PRKAB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKAB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKAB1 Gene

Chromosome:
12
Start:
119,667,753 bp from pter
End:
119,681,630 bp from pter
Size:
13,878 bases
Orientation:
Plus strand

Genomic View for PRKAB1 Gene

Genes around PRKAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAB1 Gene

Proteins for PRKAB1 Gene

  • Protein details for PRKAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y478-AAKB1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase subunit beta-1
    Protein Accession:
    Q9Y478
    Secondary Accessions:
    • Q9UBV0
    • Q9UE20
    • Q9UEX2
    • Q9Y6V8

    Protein attributes for PRKAB1 Gene

    Size:
    270 amino acids
    Molecular mass:
    30382 Da
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    SequenceCaution:
    • Sequence=AAB71326.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC98897.1; Type=Frameshift; Positions=245; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKAB1 Gene

neXtProt entry for PRKAB1 Gene

Proteomics data for PRKAB1 Gene at MOPED

Post-translational modifications for PRKAB1 Gene

  • Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
  • Ubiquitination at Lys 57, Lys 89, Lys 102, and Lys 195
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKAB1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKAB1 (AMPK beta 1)

No data available for DME Specific Peptides for PRKAB1 Gene

Domains & Families for PRKAB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y478

UniProtKB/Swiss-Prot:

AAKB1_HUMAN :
  • The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
  • Belongs to the 5-AMP-activated protein kinase beta subunit family.
Domain:
  • The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
Family:
  • Belongs to the 5-AMP-activated protein kinase beta subunit family.
genes like me logo Genes that share domains with PRKAB1: view

Function for PRKAB1 Gene

Molecular function for PRKAB1 Gene

GENATLAS Biochemistry:
protein kinase,cAMP activated,beta 1 non catalytic subunit,involved in fatty acid and cholesterol metabolism,expressed in liver,skeletal muscle
UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Gene Ontology (GO) - Molecular Function for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PRKAB1: view
genes like me logo Genes that share phenotypes with PRKAB1: view

Animal Models for PRKAB1 Gene

MGI Knock Outs for PRKAB1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAB1 Gene

Localization for PRKAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAB1 Gene COMPARTMENTS Subcellular localization image for PRKAB1 gene
Compartment Confidence
cytosol 5
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031588 nucleotide-activated protein kinase complex IEA --
genes like me logo Genes that share ontologies with PRKAB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKAB1 Gene

Pathways & Interactions for PRKAB1 Gene

genes like me logo Genes that share pathways with PRKAB1: view

SIGNOR curated interactions for PRKAB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IDA 17028174
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
genes like me logo Genes that share ontologies with PRKAB1: view

Drugs & Compounds for PRKAB1 Gene

(38) Drugs for PRKAB1 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma activator, inhibitor, Target, inducer AMP-activated protein kinase (AMPK) activator 1668
Aspirin Approved Pharma Channel blocker, Target, activator 1059
Adenosine monophosphate Approved Nutra Target, activator 0
AICAR Experimental Pharma AMPK activator 0
A-769662 Pharma AMPK activator,potent and reversible, Potent AMPK activator 0

(29) Additional Compounds for PRKAB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Metformin hydrochloride
1115-70-4
PT 1
331002-70-1

(5) Tocris Compounds for PRKAB1 Gene

Compound Action Cas Number
A 769662 Potent AMPK activator 844499-71-4
AICAR AMPK activator 2627-69-2
Cryptotanshinone STAT3 inhibitor. Also displays multiple other activities 35825-57-1
Metformin hydrochloride Activator of LKB1/AMPK; antidiabetic agent 1115-70-4
PT 1 AMPK activator 331002-70-1

(4) ApexBio Compounds for PRKAB1 Gene

Compound Action Cas Number
A-769662 AMPK activator,potent and reversible 844499-71-4
AICAR AMPK activator 2627-69-2
Dorsomorphin 2HCl AMPK inhibitor 1219168-18-9
Phenformin HCl 834-28-6
genes like me logo Genes that share compounds with PRKAB1: view

Transcripts for PRKAB1 Gene

Unigene Clusters for PRKAB1 Gene

Protein kinase, AMP-activated, beta 1 non-catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for PRKAB1 Gene

GeneLoc Exon Structure for
PRKAB1
ECgene alternative splicing isoforms for
PRKAB1

Expression for PRKAB1 Gene

mRNA expression in normal human tissues for PRKAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKAB1 Gene

This gene is overexpressed in Lung (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAB1 Gene



SOURCE GeneReport for Unigene cluster for PRKAB1 Gene Hs.741184

genes like me logo Genes that share expression patterns with PRKAB1: view

Protein tissue co-expression partners for PRKAB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKAB1 Gene

Orthologs for PRKAB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKAB1 35
  • 91.11 (n)
  • 97.04 (a)
PRKAB1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAB1 35
  • 93.21 (n)
  • 98.52 (a)
PRKAB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkab1 35
  • 89.14 (n)
  • 96.67 (a)
Prkab1 16
Prkab1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKAB1 35
  • 99.63 (n)
  • 100 (a)
PRKAB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkab1 35
  • 89.88 (n)
  • 95.91 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKAB1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAB1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKAB1 35
  • 82.4 (n)
  • 92.57 (a)
PRKAB1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAB1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkab1 35
  • 75 (n)
  • 86.36 (a)
Str.11311 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14126 35
prkab1a 35
  • 74.06 (n)
  • 82.33 (a)
prkab1a 36
  • 81 (a)
ManyToMany
prkab1b 36
  • 76 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9296 35
fruit fly
(Drosophila melanogaster)
Insecta CG8057 37
  • 62 (a)
alc 35
  • 61.88 (n)
  • 64.89 (a)
alc 36
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008195 35
  • 58.96 (n)
  • 62.9 (a)
worm
(Caenorhabditis elegans)
Secernentea F55F3.1 37
  • 46 (a)
Y47D3A.15 37
  • 43 (a)
aakb-1 36
  • 43 (a)
ManyToMany
aakb-2 36
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIP2 36
  • 20 (a)
ManyToMany
GAL83 36
  • 19 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16360 35
  • 50.09 (n)
  • 40.44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1122 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03837 35
  • 46.91 (n)
  • 40.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes amk2 35
  • 47.34 (n)
  • 39.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10258 36
  • 51 (a)
OneToMany
Species with no ortholog for PRKAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAB1 Gene

ENSEMBL:
Gene Tree for PRKAB1 (if available)
TreeFam:
Gene Tree for PRKAB1 (if available)

Paralogs for PRKAB1 Gene

Paralogs for PRKAB1 Gene

(1) SIMAP similar genes for PRKAB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRKAB1: view

Variants for PRKAB1 Gene

Sequence variations from dbSNP and Humsavar for PRKAB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4213 -- 119,681,378(+) CTTCT(G/T)TATAC utr-variant-3-prime
rs278143 -- 119,671,209(+) TGCCT(A/G)TTTTC intron-variant
rs278144 -- 119,673,368(+) ATAAA(A/G)TGAGG intron-variant
rs278145 -- 119,674,294(+) AACTC(C/T)GCAGA intron-variant
rs278146 -- 119,675,190(+) AGGGA(A/G)GCAGT intron-variant

Variation tolerance for PRKAB1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKAB1 Gene

HapMap Linkage Disequilibrium report
PRKAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRKAB1 Gene

Disorders for PRKAB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKAB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
liver disease
  • disorder of liver
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRKAB1

Genetic Association Database (GAD)
PRKAB1
Human Genome Epidemiology (HuGE) Navigator
PRKAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKAB1
genes like me logo Genes that share disorders with PRKAB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAB1 Gene

Publications for PRKAB1 Gene

  1. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PMID: 21460634) Loffler A.S. … Stork B. (Autophagy 2011) 3 4 67
  2. Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts. (PMID: 20177150) Kwon H.J. … Yeo E.J. (Exp. Mol. Med. 2010) 3 23
  3. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. (PMID: 19896469) GarcA-a-GarcA-a C. … LA^pez-Rivas A. (Biochem. Pharmacol. 2010) 3 23
  4. Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. (PMID: 19592618) Li X.N. … Shen Y.H. (Diabetes 2009) 3 23
  5. SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase. (PMID: 19720090) Zhang H.S. … Wu M.R. (Virus Res. 2009) 3 23

Products for PRKAB1 Gene

Sources for PRKAB1 Gene

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