PRKAB1 Gene
protein-coding GIFtS: 66
GCID: GC12P120105
|
|
protein kinase, AMP-activated, beta 1 non-catalytic subunit
| |
Aliases
for PRKAB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit1 2 | | HAMPKb2 | | AMPK2 3 | | AMP-Activated Protein Kinase Beta Subunit2 | | AMPKb2 3 | | AMPK Beta -1 Chain2 | | AMPK Subunit Beta-12 3 | | AMPK Beta 12 | | 5'-AMP-Activated Protein Kinase Beta-1 Subunit2 | | Protein Kinase, AMP-Activated, Noncatalytic, Beta-12 | | 5'-AMP-Activated Protein Kinase Subunit Beta-12 | | |
Export aliases for PRKAB1 gene to outside databasesPrevious GC identifers: GC12P118978 GC12P119632 GC12P119888 GC12P118517 GC12P118568 GC12P117113 |
Summaries
for PRKAB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRKAB1:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is aheterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an importantenergy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK isactivated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxybeta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid andcholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of thissubunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serveas an adaptor molecule mediating the association of the AMPK complex. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays akey role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPKactivates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipidbiosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, andby longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarityby remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as ascaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gammasubunits (PRKAG1, PRKAG2 or PRKAG3)
 summary
for PRKAB1: AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of
alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of
cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to
stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis.
The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by
phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by
calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates
allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in
metabolically active tissues such as the skeletal muscles and liver.
Gene Wiki entry for PRKAB1
|
Genomic Views
for PRKAB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRKAB1 gene promoter:
GR GR-beta FAC1 PPAR-gamma1 HOXA5 GR-alpha PPAR-gamma2 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRKAB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRKAB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.1-q24.3 Ensembl cytogenetic band: 12q24.23 HGNC cytogenetic band: 12q24.1-q24.3PRKAB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P120105: view genomic region
(about GC identifiers)
Start:
|
120,105,558 bp from pter |
End:
|
120,119,435 bp from pter |
Size:
|
13,878 bases |
Orientation:
|
plus strand |
|
Proteins
for PRKAB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478 (See
protein sequence)Recommended Name: 5'-AMP-activated protein kinase subunit beta-1 Size: 270 amino acids; 30382 Da
Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gammanon-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2
Sequence caution: Sequence=AAB71326.1; Type=Erroneous gene model prediction; Sequence=AAC98897.1; Type=Frameshift;Positions=245;
Secondary accessions: Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8Explore the universe of human proteins at neXtProt for PRKAB1: NX_Q9Y478
Post-translational modifications:
Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading tonegatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y478
PRKAB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006244.2
ENSEMBL proteins: ENSP00000229328 ENSP00000441369 ENSP00000444816 ENSP00000439235 ENSP00000437993 Reactome Protein details: Q9Y478
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PRKAB1 for ontologies About GeneDecksing
PRKAB1 Antibody Products:
Assay Products for PRKAB1: |
Protein
Domains /
Families
for PRKAB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRKAB1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y478ProtoNet protein and cluster: Q9Y478 1 Blocks protein family: IPB006828 5-AMP-activated protein kinase
UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478Domain: The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranchingenzyme or protein phosphatases can directly affect AMPK activity (By similarity)Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family |
Function
for PRKAB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays akey role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPKactivates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipidbiosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, andby longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarityby remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as ascaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gammasubunits (PRKAG1, PRKAG2 or PRKAG3) Genatlas biochemistry entry for PRKAB1: protein kinase,cAMP activated,beta 1 non catalytic subunit,involved in fatty acid and cholesterol metabolism,expressedin liver,skeletal muscle
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: PRKAB1 (NM_006253) | |  | Sino Biological Human cDNA Clone for PRKAB1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKAB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAB1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PRKAB1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for PRKAB1:
Animal Models:
Mouse knock-out Prkab1tm1Eihl for PRKAB1
13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Prkab1):
PRKAB1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PRKAB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | IRS-related events | | | 2 | Development_Leptin signaling via PI3K-dependent pathway | | | 3 | Energy dependent regulation of mTOR by LKB1-AMPK | | | 4 | mTOR signalling | | | 5 | Membrane Trafficking | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for PRKAB1
1  R&D Systems Pathway for PRKAB1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRKAB1
1 
Cell Signaling Technology (CST) Pathway for PRKAB1
1 Tocris Bioscience Pathway for PRKAB1
2  GeneGo (Thomson Reuters) Pathways for PRKAB1
4  BioSystems Pathways for PRKAB1
5/16 
Reactome Pathways for PRKAB1 (see all 16)
1  PharmGKB Pathway for PRKAB1
3 
Kegg Pathways (Kegg details for PRKAB1):
PRKAB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRKAB1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/385 Interacting proteins for PRKAB1 (Q9Y4781, 2, 3 ENSP000002293284) via UniProtKB, MINT, STRING, and/or I2D (see all 385)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
PRKAB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRKAB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PRKAB1 for compounds About GeneDecksing
Compounds for PRKAB1 available from Tocris Bioscience About this table
2 DrugBank Compounds for PRKAB1 About this table
10/59 Novoseek chemical compound relationships for PRKAB1 gene (see all 59) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| aicar |
98.5 |
318 |
12791703 (6), 11016448 (5), 16760336 (4), 17603555 (4) (see all 99) |
| acadesine |
95.3 |
66 |
12522004 (6), 11546797 (3), 12452797 (3), 12791703 (3) (see all 37) |
| acetyl-coa |
84.1 |
53 |
15327994 (1), 16505231 (1), 19100718 (1), 19001513 (1) (see all 42) |
| metformin |
81.6 |
78 |
17123942 (6), 16636195 (4), 19001513 (3), 17603555 (3) (see all 38) |
| phenformin |
80.4 |
14 |
17603555 (4), 17287212 (2), 16620785 (2), 17617058 (1) (see all 5) |
| 5-iodotubercidin |
79.1 |
5 |
18326758 (1), 18195011 (1), 10933890 (1), 17615555 (1) (see all 5) |
| aica |
73 |
1 |
16985054 (1) |
| malonyl-coa |
72.2 |
7 |
14500570 (3), 11420304 (1), 10334449 (1), 16949049 (1) |
| fatty acid |
68 |
84 |
17173081 (6), 16822822 (4), 16710744 (3), 20407084 (2) (see all 43) |
| glucose |
67.5 |
199 |
17287212 (6), 17173081 (6), 10933890 (6), 15265762 (5) (see all 77) |
Search CenterWatch for drugs/clinical trials and news about PRKAB1 / AAKB1
|
Transcripts
for PRKAB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRKAB1 gene: NM_006253.4 Unigene Cluster for PRKAB1: Protein kinase, AMP-activated, beta 1 non-catalytic subunit Hs.741184 [show with all ESTs]Unigene Representative Sequence: BC0018239 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229328(uc001txg.3) ENST00000541640(uc009zwu.3) ENST00000537400
ENST00000540121 ENST00000545223 ENST00000545870 ENST00000542698 ENST00000538271
ENST00000537057
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAB1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRKAB1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRKAB1 (NM_006253) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRKAB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAB1 |
Additional cDNA sequence: AF022116.1 AJ224515.1 AK301165.1 AK312495.1 BC001007.2 BC001056.2 BC001823.2 BC017671.1 BC018818.2 U83994.1 Y12556.1 14 DOTS entries: DT.219613 DT.95099394 DT.95210112 DT.100650911 DT.121215707 DT.121215709 DT.121215727 DT.95331064 DT.95331068 DT.95331070 DT.97847399 DT.121215753 DT.95194230 DT.95362459 24/374 AceView cDNA sequences (see all 374): BM826980 AI423363 AI241660 AA330964 BU539177 BM728507 BQ927263 BQ421272 AA345751 AW512746 AA435980 AI304758 AL698893 BG057813 AA496156 BE906675 AA044766 AI569342 AI630549 BP335583 BC001056 CF126292 BM993523 BM711001
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PRKAB1
|
Expression
for PRKAB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRKAB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTCTGCTC
About this image
See PRKAB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRKAB1
SOURCE GeneReport for Unigene cluster: Hs.741184
SABiosciences Expression via Pathway-Focused PCR Arrays including PRKAB1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRKAB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRKAB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRKAB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRKAB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAB1 |
Orthologs
for PRKAB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PRKAB1 gene from 9/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Prkab11 , 5 |
protein kinase, AMP-activated, beta 1 non-catalytic more1, 5 |
89.14(n)1
96.67(a)1 |
|
5 (56.10 cM)5
190791 NM_031869.21 NP_114075.11
1160135865 |
chicken
(Gallus gallus) |
Aves |
PRKAB11 |
protein kinase, AMP-activated, beta 1 non-catalytic more |
82.4(n)
92.57(a) |
|
416986 NM_001039912.1 NP_001035001.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PRKAB16 |
-- |
92(a) |
1 ↔ 1 |
GL343338.1(269524-272525) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CD328675.12 |
-- |
77.06(n) |
|
CD328675.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.141262 |
Transcribed sequence with moderate similarity to protein more |
77.44(n) |
|
CK028313.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG80573
alc1 |
SNF1A/AMP-activated protein kinase3
alicorn1 |
62(a)3
61.88(n)1
64.89(a)1 |
|
45A113
359311 NM_136616.41 NP_610460.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
F55F3.13 |
-- |
46(a)
(best of 2) |
|
X(13791061-13793948) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G163601 |
SNF1-related protein kinase regulatory subunit beta-2 |
50.09(n)
40(a) |
|
827331 NM_117731.6 NP_193369.2 |
rice
(Oryza sativa) |
Liliopsida |
----(see all 4) |
SNF1-related protein kinase regulatory subunit bet...SNF1-related protein kinase regulatory subunit bet...(see all 4) |
28(a)23(a)(see all 4) |
many ↔ manymany ↔ many(see all 4) |
9(11984970-11988562) 3(11506280-11511064) |
ENSEMBL Gene Tree for PRKAB1 (if available)
TreeFam Gene Tree for PRKAB1 (if available) |
Paralogs
for PRKAB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRKAB1 gene
- PRKAB22
1 SIMAP similar gene for PRKAB1 using alignment to 4 protein entries: AAKB1_HUMAN (see all proteins):PRKAB2
PRKAB1 for paralogs About GeneDecksing
|
Genomic Variants
for PRKAB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRKAB1 (120105558 - 120119435 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRKAB1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRKAB1 |
|
Disorders
/ Diseases
for PRKAB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRKAB1 for disorders About GeneDecksing
OMIM gene information: 602740
OMIM disorders: --
20/58  diseases for PRKAB1 (see all 58): About MalaCardsmaturity-onset diabetes of the young cholesterol tuberous sclerosis insulin resistance
metabolic disorders friedreich ataxia mantle cell lymphoma krabbe disease
fatty liver disease lafora disease cytomegalovirus infection acute lymphoblastic leukemia
chronic lymphocytic leukemia lymphoblastic leukemia acute myeloid leukemia epithelial ovarian cancer
lymphocytic leukemia myeloid leukemia cushing's syndrome tauopathy
10/25 Novoseek disease relationships for PRKAB1 gene (see all 25) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| insulin sensitivity |
59.6 |
28 |
16634986 (2), 15033479 (2), 17208384 (2), 15230153 (1) (see all 16) |
| obesity |
54.4 |
15 |
19138981 (1), 16622294 (1), 17021375 (1), 17144168 (1) (see all 12) |
| insulin resistance |
51.5 |
5 |
16709632 (2), 15681023 (1), 16054041 (1) |
| metabolic disorder |
51.4 |
6 |
19628050 (1), 17144168 (1), 17496363 (1), 17026483 (1) (see all 6) |
| hyperinsulinemia |
35.8 |
3 |
19100718 (1), 19136982 (1) |
| colon cancer |
32.1 |
23 |
17404062 (4), 16797120 (4), 17047069 (3), 17341607 (2) (see all 10) |
| cancer |
28 |
46 |
17404056 (5), 15681023 (3), 16797120 (3), 19093868 (3) (see all 20) |
| hyperglycemia |
24.4 |
2 |
10866040 (1), 19635557 (1) |
| vascular diseases |
17.5 |
2 |
16636195 (1), 16151020 (1) |
| necrosis |
16.4 |
1 |
17513605 (1) |
Human Genome Epidemiology (HuGE) Navigator: PRKAB1 (11 documents)
Export disorders for PRKAB1 gene to outside databases
|
Publications
for PRKAB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRKAB1 gene, integrated from 9 sources (see all 484):
(articles sorted by number of sources associating them with PRKAB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)1, 2 Loffler A.S.... Stork B. (2011)
- Identification and characterization of a novel folliculin-interacting protein FNIP2. (PubMed id 18403135)1, 2 Hasumi H.... Schmidt L.S. (2008)
- AMP-activated protein kinase in metabolic control and insulin signaling. (PubMed id 17307971)2, 7 Towler M.C. and Hardie D.G. (2007)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PubMed id 17028174)1, 2 Baba M....Zbar B. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. (PubMed id 9224708)1, 2 Stapleton D.... Kemp B.E. (1997)
- Mammalian AMP-activated protein kinase subfamily. (PubMed id 8557660)1, 3 Stapleton D.... Kemp B.E. (1996)
- AMP-activated protein kinase plays a role in the control of food intake. (PubMed id 14742438)1, 9 Andersson U....Small C.J. (2004)
- Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. (PubMed id 17669398)1, 9 Baumann P....Schmidmaier R. (2007)
|
External Searches for PRKAB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRKAB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRKAB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRKAB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PRKAB1 gene:
Search GeneIP for patents involving PRKAB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRKAB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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