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Aliases for PRKAB1 Gene

Aliases for PRKAB1 Gene

  • Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1 2 3 5
  • Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit 2 3
  • AMPK Subunit Beta-1 3 4
  • AMPK Beta 1 2 3
  • AMPKb 3 4
  • AMPK 3 4
  • Protein Kinase, AMP-Activated, Noncatalytic, Beta-1 3
  • 5-AMP-Activated Protein Kinase Beta-1 Subunit 3
  • 5-AMP-Activated Protein Kinase Subunit Beta-1 3
  • AMP-Activated Protein Kinase Beta Subunit 3
  • AMPK Beta -1 Chain 3
  • HAMPKb 3

External Ids for PRKAB1 Gene

Previous GeneCards Identifiers for PRKAB1 Gene

  • GC12P118978
  • GC12P119888
  • GC12P118517
  • GC12P118568
  • GC12P120105
  • GC12P117113

Summaries for PRKAB1 Gene

Entrez Gene Summary for PRKAB1 Gene

  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAB1 Gene

PRKAB1 (Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1) is a Protein Coding gene. Diseases associated with PRKAB1 include Fatty Liver Disease and Obesity. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include protein kinase activity and AMP-activated protein kinase activity. An important paralog of this gene is PRKAB2.

UniProtKB/Swiss-Prot for PRKAB1 Gene

  • Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Tocris Summary for PRKAB1 Gene

  • AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival during times of cellular metabolic stress.

Gene Wiki entry for PRKAB1 Gene

Additional gene information for PRKAB1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAB1 Gene

Genomics for PRKAB1 Gene

Regulatory Elements for PRKAB1 Gene

Enhancers for PRKAB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H120198 1.7 FANTOM5 ENCODE dbSUPER 19.9 +532.7 532699 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 GCN1 RAB35 RPL31P52 SRSF9 PRKAB1 ENSG00000256695 RPL12P33 LOC105370025 ENSG00000256963 ENSG00000201945
GH12H119666 1.4 ENCODE dbSUPER 18.5 +3.4 3400 8 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 PRKAB1 GCN1 RPLP0 TMEM233 LOC105370027 ENSG00000255692
GH12H120528 1.2 ENCODE 19.9 +861.7 861692 2 ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 NBN GCN1 ANAPC5 COQ5 RPL31P52 RPL29P24 PRKAB1 GATC ENSG00000256695 RPL12P33 ENSG00000256963
GH12H119678 1.4 Ensembl ENCODE dbSUPER 14.4 +15.7 15678 9 ELF3 FOXA2 ARID4B RAD21 YY1 SLC30A9 ATF7 RUNX3 CREM MIXL1 PRKAB1 MIR1178 CIT LOC105370027 TMEM233 ENSG00000255692
GH12H120261 1.6 FANTOM5 ENCODE dbSUPER 11.7 +596.2 596177 5 PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A BRCA1 GTF3C2 ZNF766 GLIS2 GCN1 PRKAB1 PXN SIRT4 RPLP0 MSI1 RAB35 RPS20P31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKAB1 on UCSC Golden Path with GeneCards custom track

Promoters for PRKAB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058233 447 2001 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for PRKAB1 Gene

Chromosome:
12
Start:
119,667,753 bp from pter
End:
119,681,630 bp from pter
Size:
13,878 bases
Orientation:
Plus strand

Genomic View for PRKAB1 Gene

Genes around PRKAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAB1 Gene

Proteins for PRKAB1 Gene

  • Protein details for PRKAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y478-AAKB1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase subunit beta-1
    Protein Accession:
    Q9Y478
    Secondary Accessions:
    • Q9UBV0
    • Q9UE20
    • Q9UEX2
    • Q9Y6V8

    Protein attributes for PRKAB1 Gene

    Size:
    270 amino acids
    Molecular mass:
    30382 Da
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    SequenceCaution:
    • Sequence=AAB71326.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC98897.1; Type=Frameshift; Positions=245; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKAB1 Gene

neXtProt entry for PRKAB1 Gene

Post-translational modifications for PRKAB1 Gene

  • Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
  • Ubiquitination at isoforms=57, Lys89, isoforms=102, and Lys195
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKAB1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKAB1 (AMPKB1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for PRKAB1

No data available for DME Specific Peptides for PRKAB1 Gene

Domains & Families for PRKAB1 Gene

Gene Families for PRKAB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y478

UniProtKB/Swiss-Prot:

AAKB1_HUMAN :
  • The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
  • Belongs to the 5-AMP-activated protein kinase beta subunit family.
Domain:
  • The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
Family:
  • Belongs to the 5-AMP-activated protein kinase beta subunit family.
genes like me logo Genes that share domains with PRKAB1: view

Function for PRKAB1 Gene

Molecular function for PRKAB1 Gene

GENATLAS Biochemistry:
protein kinase,cAMP activated,beta 1 non catalytic subunit,involved in fatty acid and cholesterol metabolism,expressed in liver,skeletal muscle
UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Phenotypes From GWAS Catalog for PRKAB1 Gene

Gene Ontology (GO) - Molecular Function for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17028174
GO:0004679 AMP-activated protein kinase activity IEA --
GO:0005515 protein binding IPI 16306228
GO:0016301 kinase activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PRKAB1: view
genes like me logo Genes that share phenotypes with PRKAB1: view

Animal Models for PRKAB1 Gene

MGI Knock Outs for PRKAB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRKAB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKAB1 Gene

Localization for PRKAB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKAB1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0031588 nucleotide-activated protein kinase complex IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with PRKAB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKAB1 Gene

Pathways & Interactions for PRKAB1 Gene

genes like me logo Genes that share pathways with PRKAB1: view

SIGNOR curated interactions for PRKAB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 17028174
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0007050 cell cycle arrest TAS --
genes like me logo Genes that share ontologies with PRKAB1: view

Drugs & Compounds for PRKAB1 Gene

(51) Drugs for PRKAB1 Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Metformin Approved Pharma activator, inhibitor, Target, inducer AMP-activated protein kinase (AMPK) activator 1849
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, activator 1196
Adenosine monophosphate Approved Nutra Target, activator 0
AICAR Experimental Pharma AMPK activator 0
Imeglimin Investigational Pharma Antidiabetic agent 0

(27) Additional Compounds for PRKAB1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dorsomorphin dihydrochloride
1219168-18-9
Metformin hydrochloride
1115-70-4
ZLN 024 hydrochloride

(5) Tocris Compounds for PRKAB1 Gene

Compound Action Cas Number
Dorsomorphin dihydrochloride Potent and selective AMPK inhibitor 1219168-18-9
Metformin hydrochloride Activator of LKB1/AMPK; antidiabetic agent 1115-70-4
PT 1 AMPK activator 331002-70-1
RSVA 405 AMPK activator; also STAT3 inhibitor 140405-36-3
ZLN 024 hydrochloride Allosteric AMPK activator

(15) ApexBio Compounds for PRKAB1 Gene

Compound Action Cas Number
A-769662 AMPK activator,potent and reversible 844499-71-4
AICAR AMPK activator 2627-69-2
AICAR phosphate AMPK activator 681006-28-0
Dorsomorphin AMPK inhibitor 866405-64-3
Dorsomorphin 2HCl AMPK inhibitor 1219168-18-9
GSK621 AMPK agonist 1346607-05-3
Imeglimin Antidiabetic agent 775351-65-0
Imeglimin hydrochloride Antidiabetic agent 775351-61-6
Phenformin HCl 834-28-6
PT 1 AMPK activator, selective 331002-70-1
RSVA 405 140405-36-3
SAMS Peptide 125911-68-4
YLF-466D 1273323-67-3
ZLN024 723249-01-2
ZLN024 hydrochloride
genes like me logo Genes that share compounds with PRKAB1: view

Drug Products

Transcripts for PRKAB1 Gene

Unigene Clusters for PRKAB1 Gene

Protein kinase, AMP-activated, beta 1 non-catalytic subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRKAB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for PRKAB1 Gene

GeneLoc Exon Structure for
PRKAB1
ECgene alternative splicing isoforms for
PRKAB1

Expression for PRKAB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRKAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRKAB1 Gene

This gene is overexpressed in Lung (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRKAB1 Gene



Protein tissue co-expression partners for PRKAB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRKAB1 Gene:

PRKAB1

SOURCE GeneReport for Unigene cluster for PRKAB1 Gene:

Hs.741184

Evidence on tissue expression from TISSUES for PRKAB1 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Muscle(4.4)
  • Lung(4.3)
  • Blood(4.1)
  • Intestine(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with PRKAB1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRKAB1 Gene

Orthologs for PRKAB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAB1 33 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia PRKAB1 33 34
  • 93.21 (n)
cow
(Bos Taurus)
Mammalia PRKAB1 34 33
  • 91.11 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAB1 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkab1 33
  • 89.88 (n)
mouse
(Mus musculus)
Mammalia Prkab1 16 34 33
  • 89.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAB1 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKAB1 33 34
  • 82.4 (n)
lizard
(Anolis carolinensis)
Reptilia PRKAB1 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkab1 33
  • 75 (n)
Str.11311 33
zebrafish
(Danio rerio)
Actinopterygii prkab1b 34
  • 76 (a)
ManyToMany
prkab1a 33 34
  • 74.06 (n)
Dr.14126 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9296 33
fruit fly
(Drosophila melanogaster)
Insecta CG8057 35
  • 62 (a)
alc 33 34
  • 61.88 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008195 33
  • 58.96 (n)
worm
(Caenorhabditis elegans)
Secernentea F55F3.1 35
  • 46 (a)
Y47D3A.15 35
  • 43 (a)
aakb-1 34
  • 43 (a)
ManyToMany
aakb-2 34
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIP2 34
  • 20 (a)
ManyToMany
GAL83 34
  • 19 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16360 33
  • 50.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10258 34
  • 51 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes amk2 33
  • 47.34 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03837 33
  • 46.91 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1122 33
Species where no ortholog for PRKAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAB1 Gene

ENSEMBL:
Gene Tree for PRKAB1 (if available)
TreeFam:
Gene Tree for PRKAB1 (if available)

Paralogs for PRKAB1 Gene

Paralogs for PRKAB1 Gene

(1) SIMAP similar genes for PRKAB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRKAB1: view

Variants for PRKAB1 Gene

Sequence variations from dbSNP and Humsavar for PRKAB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000823190 -- 119,681,204(+) CCTAT(-/A)AAAAT utr-variant-3-prime
rs1000985107 -- 119,666,051(+) CCATC(C/T)CTTTT intron-variant, upstream-variant-2KB
rs1001160938 -- 119,670,025(+) GCAGG(C/G)CAGTG intron-variant
rs1001874302 -- 119,671,130(+) TCAGT(C/T)TTTGT intron-variant
rs1001881694 -- 119,673,237(+) AAAAG(A/G)AAAGA intron-variant

Variation tolerance for PRKAB1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRKAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRKAB1 Gene

Disorders for PRKAB1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKAB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fatty liver disease
  • alcoholic fatty liver
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRKAB1

Genetic Association Database (GAD)
PRKAB1
Human Genome Epidemiology (HuGE) Navigator
PRKAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKAB1
genes like me logo Genes that share disorders with PRKAB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKAB1 Gene

Publications for PRKAB1 Gene

  1. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PMID: 21460634) Löffler AS … Stork B (Autophagy 2011) 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PMID: 20682687) Jablonski KA … Diabetes Prevention Program Research Group (Diabetes 2010) 3 45 60
  4. AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. (PMID: 19896469) García-García C … López-Rivas A (Biochemical pharmacology 2010) 3 22 60
  5. Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts. (PMID: 20177150) Kwon HJ … Yeo EJ (Experimental & molecular medicine 2010) 3 22 60

Products for PRKAB1 Gene

Sources for PRKAB1 Gene

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