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Aliases for PRKAB1 Gene

Aliases for PRKAB1 Gene

  • Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit 2 3
  • AMPK Subunit Beta-1 3 4
  • AMPK Beta 1 2 3
  • AMPKb 3 4
  • AMPK 3 4
  • Protein Kinase, AMP-Activated, Noncatalytic, Beta-1 3
  • 5-AMP-Activated Protein Kinase Beta-1 Subunit 3
  • 5-AMP-Activated Protein Kinase Subunit Beta-1 3
  • AMP-Activated Protein Kinase Beta Subunit 3
  • AMPK Beta -1 Chain 3
  • HAMPKb 3

External Ids for PRKAB1 Gene

Summaries for PRKAB1 Gene

Entrez Gene Summary for PRKAB1 Gene

  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAB1 Gene

PRKAB1 (Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit) is a Protein Coding gene. Diseases associated with PRKAB1 include krabbe disease. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include protein kinase binding and protein kinase activity. An important paralog of this gene is PRKAB2.

UniProtKB/Swiss-Prot for PRKAB1 Gene

  • Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

Tocris Summary for PRKAB1 Gene

  • AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.

Gene Wiki entry for PRKAB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAB1 Gene

Genomics for PRKAB1 Gene

Genomic Location for PRKAB1 Gene

Start:
119,667,753 bp from pter
End:
119,681,630 bp from pter
Size:
13,878 bases
Orientation:
Plus strand

Genomic View for PRKAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAB1 Gene

Regulatory Elements for PRKAB1 Gene

Proteins for PRKAB1 Gene

  • Protein details for PRKAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y478-AAKB1_HUMAN
    Recommended name:
    5-AMP-activated protein kinase subunit beta-1
    Protein Accession:
    Q9Y478
    Secondary Accessions:
    • Q9UBV0
    • Q9UE20
    • Q9UEX2
    • Q9Y6V8

    Protein attributes for PRKAB1 Gene

    Size:
    270 amino acids
    Molecular mass:
    30382 Da
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
    SequenceCaution:
    • Sequence=AAB71326.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAC98897.1; Type=Frameshift; Positions=245; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRKAB1 Gene

neXtProt entry for PRKAB1 Gene

Proteomics data for PRKAB1 Gene at MOPED

Post-translational modifications for PRKAB1 Gene

  • Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys57, Lys89, Lys102, Lys195, and Lys268

Other Protein References for PRKAB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PRKAB1 Gene

Domains for PRKAB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y478

UniProtKB/Swiss-Prot:

AAKB1_HUMAN
Domain:
  • The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.:
    • Q9Y478
Family:
  • Belongs to the 5-AMP-activated protein kinase beta subunit family.:
    • Q9Y478
genes like me logo Genes that share domains with PRKAB1: view

Function for PRKAB1 Gene

Molecular function for PRKAB1 Gene

GENATLAS Biochemistry: protein kinase,cAMP activated,beta 1 non catalytic subunit,involved in fatty acid and cholesterol metabolism,expressed in liver,skeletal muscle
UniProtKB/Swiss-Prot Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

Gene Ontology (GO) - Molecular Function for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 17028174
GO:0004679 AMP-activated protein kinase activity IEA --
GO:0005515 protein binding IPI 16306228
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PRKAB1: view
genes like me logo Genes that share phenotypes with PRKAB1: view

Animal Models for PRKAB1 Gene

MGI Knock Outs for PRKAB1:

miRNA for PRKAB1 Gene

miRTarBase miRNAs that target PRKAB1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRKAB1 Gene

Localization for PRKAB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAB1 Gene COMPARTMENTS Subcellular localization image for PRKAB1 gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0031588 AMP-activated protein kinase complex IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with PRKAB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRKAB1 Gene

Pathways for PRKAB1 Gene

genes like me logo Genes that share pathways with PRKAB1: view

Gene Ontology (GO) - Biological Process for PRKAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation IDA 17028174
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
genes like me logo Genes that share ontologies with PRKAB1: view

Compounds for PRKAB1 Gene

(4) Tocris Compounds for PRKAB1 Gene

Compound Action Cas Number
A 769662 Potent AMPK activator [844499-71-4]
Dorsomorphin dihydrochloride Potent and selective AMPK inhibitor [1219168-18-9]
Metformin hydrochloride Activator of LKB1/AMPK; antidiabetic agent [1115-70-4]
PT 1 AMPK activator [331002-70-1]

(2) Drugbank Compounds for PRKAB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8 target activator
Metformin
657-24-9 target inducer

(59) Novoseek inferred chemical compound relationships for PRKAB1 Gene

Compound -log(P) Hits PubMed IDs
aicar 98.5 186
acadesine 95.3 51
acetyl-coa 84.1 42
metformin 81.6 59
phenformin 80.4 10
genes like me logo Genes that share compounds with PRKAB1: view

Transcripts for PRKAB1 Gene

Unigene Clusters for PRKAB1 Gene

Protein kinase, AMP-activated, beta 1 non-catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for PRKAB1 Gene

GeneLoc Exon Structure for
PRKAB1
ECgene alternative splicing isoforms for
PRKAB1

Expression for PRKAB1 Gene

mRNA expression in normal human tissues for PRKAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAB1 Gene

SOURCE GeneReport for Unigene cluster for PRKAB1 Gene Hs.741184

genes like me logo Genes that share expressions with PRKAB1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKAB1 Gene

Orthologs for PRKAB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAB1 35
  • 99.63 (n)
  • 100 (a)
PRKAB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAB1 35
  • 91.11 (n)
  • 97.04 (a)
PRKAB1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAB1 35
  • 93.21 (n)
  • 98.52 (a)
PRKAB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkab1 35
  • 89.14 (n)
  • 96.67 (a)
Prkab1 16
Prkab1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAB1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAB1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkab1 35
  • 89.88 (n)
  • 95.91 (a)
chicken
(Gallus gallus)
Aves PRKAB1 35
  • 82.4 (n)
  • 92.57 (a)
PRKAB1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAB1 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkab1 35
  • 75 (n)
  • 86.36 (a)
Str.11311 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9296 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14126 35
prkab1a 35
  • 74.06 (n)
  • 82.33 (a)
prkab1a 36
  • 81 (a)
ManyToMany
prkab1b 36
  • 76 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008195 35
  • 58.96 (n)
  • 62.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta alc 35
  • 61.88 (n)
  • 64.89 (a)
alc 36
  • 40 (a)
OneToMany
CG8057 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea aakb-1 36
  • 43 (a)
ManyToMany
aakb-2 36
  • 38 (a)
ManyToMany
F55F3.1 37
  • 46 (a)
Y47D3A.15 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL83 36
  • 19 (a)
ManyToMany
SIP2 36
  • 20 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16360 35
  • 50.09 (n)
  • 40.44 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03837 35
  • 46.91 (n)
  • 40.74 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes amk2 35
  • 47.34 (n)
  • 39.89 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1122 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10258 36
  • 51 (a)
OneToMany
Species with no ortholog for PRKAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAB1 Gene

ENSEMBL:
Gene Tree for PRKAB1 (if available)
TreeFam:
Gene Tree for PRKAB1 (if available)

Paralogs for PRKAB1 Gene

Paralogs for PRKAB1 Gene

Selected SIMAP similar genes for PRKAB1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRKAB1: view

Variants for PRKAB1 Gene

Sequence variations from dbSNP and Humsavar for PRKAB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4213 -- 119,681,378(+) CTTCT(G/T)TATAC utr-variant-3-prime
rs278143 -- 119,671,209(+) TGCCT(A/G)TTTTC intron-variant
rs278144 -- 119,673,368(+) ATAAA(A/G)TGAGG intron-variant
rs278145 -- 119,674,294(+) AACTC(C/T)GCAGA intron-variant
rs278146 -- 119,675,190(+) AGGGA(A/G)GCAGT intron-variant

Relevant External Links for PRKAB1 Gene

HapMap Linkage Disequilibrium report
PRKAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRKAB1 Gene

Disorders for PRKAB1 Gene

(1) MalaCards Diseases for PRKAB1 Gene

Search for PRKAB1 Gene in MalaCards »

(25) Novoseek inferred disease relationships for PRKAB1 Gene

Disease -log(P) Hits PubMed IDs
insulin sensitivity 59.6 19
obesity 54.4 12
insulin resistance 51.5 4
metabolic disorder 51.4 6
hyperinsulinemia 35.8 2

Relevant External Links for PRKAB1

Genetic Association Database (GAD)
PRKAB1
Human Genome Epidemiology (HuGE) Navigator
PRKAB1
genes like me logo Genes that share disorders with PRKAB1: view

No data available for UniProtKB/Swiss-Prot for PRKAB1 Gene

Publications for PRKAB1 Gene

  1. AMP-activated protein kinase plays a role in the control of food intake. (PMID: 14742438) Andersson U. … Small C.J. (J. Biol. Chem. 2004) 3 23
  2. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. (PMID: 16054041) Kahn B.B. … Hardie D.G. (Cell Metab. 2005) 3 23
  3. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism. (PMID: 14615481) Landree L.E. … Ronnett G.V. (J. Biol. Chem. 2004) 3 23
  4. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. (PMID: 15896711) Hwang J.T. … Park O.J. (Biochem. Biophys. Res. Commun. 2005) 3 23
  5. Activators of the energy sensing kinase AMPK inhibit random cell movement and chemotaxis in U937 cells. (PMID: 16405649) Kanellis J. … Power D.A. (Immunol. Cell Biol. 2006) 3 23

Products for PRKAB1 Gene

Sources for PRKAB1 Gene

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