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PRKAB1 Gene

protein-coding   GIFtS: 66
GCID: GC12P120105

Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit1 2     5'-AMP-Activated Protein Kinase Subunit Beta-12
AMPK Beta 11 2     HAMPKb2
AMPK2 3     AMP-Activated Protein Kinase Beta Subunit2
AMPKb2 3     AMPK Beta -1 Chain2
AMPK Subunit Beta-12 3     Protein Kinase, AMP-Activated, Noncatalytic, Beta-12
5'-AMP-Activated Protein Kinase Beta-1 Subunit2     

External Ids:    HGNC: 93781   Entrez Gene: 55642   Ensembl: ENSG000001117257   OMIM: 6027405   UniProtKB: Q9Y4783   

Export aliases for PRKAB1 gene to outside databases

Previous GC identifers: GC12P118978 GC12P119632 GC12P119888 GC12P118517 GC12P118568 GC12P117113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRKAB1 Gene:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a
heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an
important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses,
AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy
beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid
and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and
phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK.
This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PRKAB1 Gene:
PRKAB1 (protein kinase, AMP-activated, beta 1 non-catalytic subunit) is a protein-coding gene. Diseases associated with PRKAB1 include fumarate hydratase deficiency, and krabbe disease. GO annotations related to this gene include protein kinase binding and protein kinase activity. An important paralog of this gene is PRKAB2.

UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478
Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays
a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK
activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic
enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of
cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta
non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges
alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

summary for PRKAB1 Gene:
AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of
alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of
cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to
stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis.
The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by
phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by
calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates
allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in
metabolically active tissues such as the skeletal muscles and liver.

Gene Wiki entry for PRKAB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PRKAB1 gene promoter:
         GR   GR-beta   FAC1   PPAR-gamma1   HOXA5   GR-alpha   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRKAB1 promoter sequence
   Search Chromatin IP Primers for PRKAB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.1-q24.3   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.1-q24.3

PRKAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAB1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120105:  view genomic region     (about GC identifiers)

Start:
120,105,558 bp from pter      End:
120,119,435 bp from pter
Size:
13,878 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478 (See protein sequence)
Recommended Name: 5'-AMP-activated protein kinase subunit beta-1  
Size: 270 amino acids; 30382 Da
Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a
gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2
Sequence caution: Sequence=AAB71326.1; Type=Erroneous gene model prediction; Sequence=AAC98897.1; Type=Frameshift;
Positions=245;
2 PDB 3D structures from and Proteopedia for PRKAB1:
4CFE (3D)        4CFF (3D)    
Secondary accessions: Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8

Explore the universe of human proteins at neXtProt for PRKAB1: NX_Q9Y478

Explore proteomics data for PRKAB1 at MOPED

Post-translational modifications: 

  • Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to
    negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and
    AMPK1
  • Ubiquitination2 at Lys57, Lys89, Lys102, Lys195, Lys268
  • Modification sites at PhosphoSitePlus

  • See PRKAB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006244.2  
    ENSEMBL proteins: 
     ENSP00000229328   ENSP00000441369   ENSP00000444816   ENSP00000439235   ENSP00000437993  
    Reactome Protein details: Q9Y478

    PRKAB1 Human Recombinant Protein Products:

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    Novus Biologicals PRKAB1 Proteins
    Novus Biologicals PRKAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRKAB1
    Browse Proteins at Cloud-Clone Corp.

    PRKAB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKAB1
    R&D Systems Antibodies for PRKAB1 (AMPK beta 1)
    Cell Signaling Technology (CST) Antibodies for PRKAB1  (AMPKB1)
    OriGene Antibodies for PRKAB1
    OriGene Custom Antibody Services for PRKAB1
    Novus Biologicals PRKAB1 Antibodies
    Abcam antibodies for PRKAB1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for PRKAB1
    LSBio Antibodies in human, mouse, rat for PRKAB1

    PRKAB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PRKAB1
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, AMP-activated, beta 1 non-catalytic subunit
    AMPK subfamily
    Selected non-AGC protein kinase activities

    2 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR006828 AMP_prot_kin_bsu_interact-dom

    Graphical View of Domain Structure for InterPro Entry Q9Y478

    ProtoNet protein and cluster: Q9Y478

    1 Blocks protein domain: IPB006828 5-AMP-activated protein kinase

    UniProtKB/Swiss-Prot: AAKB1_HUMAN, Q9Y478
    Domain: The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound
    debranching enzyme or protein phosphatases can directly affect AMPK activity (By similarity)
    Similarity: Belongs to the 5'-AMP-activated protein kinase beta subunit family


    PRKAB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAKB1_HUMAN, Q9Y478
    Function: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays
    a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK
    activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
    lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic
    enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of
    cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta
    non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges
    alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

         Genatlas biochemistry entry for PRKAB1:
    protein kinase,cAMP activated,beta 1 non catalytic subunit,involved in fatty acid and cholesterol
    metabolism,expressed in liver,skeletal muscle

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA17028174
    GO:0005515protein binding IPI16306228
    GO:0019901protein kinase binding IEA--
         
    PRKAB1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRKAB1:
     Decreased viability of wild-ty  Elongated cells  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prkab1):
     adipose tissue  behavior/neurological  cellular  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  nervous system  renal/urinary system  vision/eye 

    PRKAB1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prkab1tm1Eihl for PRKAB1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKAB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKAB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKAB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKAB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKAB1:
    hsa-mir-122-5p (MIRT004527)

    Block miRNA regulation of human, mouse, rat PRKAB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKAB1 (see all 25):
    hsa-miR-2052 hsa-miR-644 hsa-miR-520d-5p hsa-miR-429 hsa-miR-539 hsa-miR-4251 hsa-miR-137 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidPRKAB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKAB1
    Predesigned siRNA for gene silencing in human, mouse, rat PRKAB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKAB1

    Clone
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    OriGene clones in human, mouse for PRKAB1 (see all 7)
    OriGene ORF clones in mouse, rat for PRKAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKAB1 (NM_006253)
    Sino Biological Human cDNA Clone for PRKAB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAB1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKAB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0031588AMP-activated protein kinase complex IEA--
    GO:0043234protein complex ----

    PRKAB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRKAB1 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTOR signalling0.39
    IRS-mediated signalling0.92
    TOR signaling0.32
    2Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    3Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    4Signaling by GPCR
    Signal Transduction0.58
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PRKAB1
        Adipocytokines & Insulin Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKAB1
        AMPK Enzyme Complex Pathway
    eNOS Signaling
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for PRKAB1
        Glucose / Energy Metabolism

    1 Tocris Bioscience Pathway for PRKAB1
        mTOR Pathway

    2 GeneGo (Thomson Reuters) Pathways for PRKAB1
        Regulation of CFTR activity (norm and CF)
    Development Leptin signaling via PI3K-dependent pathway

    4 BioSystems Pathways for PRKAB1
        TOR signaling
    AMPK signaling
    Energy Metabolism
    Direct p53 effectors


    4 Reactome Pathways for PRKAB1
        Activation of PPARGC1A (PGC-1alpha) by phosphorylation
    Regulation of Rheb GTPase activity by AMPK
    Regulation of AMPK activity via LKB1
    Translocation of GLUT4 to the plasma membrane

    1 PharmGKB Pathway for PRKAB1
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for PRKAB1) (see all 7):
        FoxO signaling pathway
    Circadian rhythm
    Insulin signaling pathway
    Adipocytokine signaling pathway
    Oxytocin signaling pathway


    PRKAB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAB1: 
              mTOR Signaling in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Prostate Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKAB1 (Q9Y4781, 2, 3 ENSP000002293284) via UniProtKB, MINT, STRING, and/or I2D (see all 445)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA17028174
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0007050cell cycle arrest TAS--
    GO:0007165signal transduction TAS9575201
    GO:0008286insulin receptor signaling pathway TAS--

    PRKAB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKAB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A 769662Potent AMPK activator[844499-71-4]
    Dorsomorphin dihydrochloridePotent and selective AMPK inhibitor[1219168-18-9]
    Metformin hydrochlorideActivator of LKB1/AMPK; antidiabetic agent[1115-70-4]
    PT 1AMPK activator[331002-70-1]

    2 DrugBank Compounds for PRKAB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Metformin-- 657-24-9targetinducer17307971 12890675 14500570 12960015 14871885 12086935 19428322 14502105
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetactivator16513051 16634986 16642960 16518831 16620308

    Selected Novoseek inferred chemical compound relationships for PRKAB1 gene (see all 59)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aicar 98.5 318 12791703 (6), 11016448 (5), 16760336 (4), 17603555 (4) (see all 99)
    acadesine 95.3 66 12522004 (6), 11546797 (3), 12452797 (3), 12791703 (3) (see all 37)
    acetyl-coa 84.1 53 15327994 (1), 16505231 (1), 19100718 (1), 19001513 (1) (see all 42)
    metformin 81.6 78 17123942 (6), 16636195 (4), 19001513 (3), 17603555 (3) (see all 38)
    phenformin 80.4 14 17603555 (4), 17287212 (2), 16620785 (2), 17617058 (1) (see all 5)
    5-iodotubercidin 79.1 5 18326758 (1), 18195011 (1), 10933890 (1), 17615555 (1) (see all 5)
    aica 73 1 16985054 (1)
    malonyl-coa 72.2 7 14500570 (3), 11420304 (1), 10334449 (1), 16949049 (1)
    fatty acid 68 84 17173081 (6), 16822822 (4), 16710744 (3), 20407084 (2) (see all 43)
    glucose 67.5 199 17287212 (6), 17173081 (6), 10933890 (6), 15265762 (5) (see all 77)



    PRKAB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRKAB1 gene: 
    NM_006253.4  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229328(uc001txg.3) ENST00000541640(uc009zwu.3) ENST00000537400
    ENST00000540121 ENST00000545223 ENST00000545870 ENST00000542698 ENST00000538271
    ENST00000537057

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    Selected qRT-PCR Assays for microRNAs that regulate PRKAB1 (see all 25):
    hsa-miR-2052 hsa-miR-644 hsa-miR-520d-5p hsa-miR-429 hsa-miR-539 hsa-miR-4251 hsa-miR-137 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidPRKAB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRKAB1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRKAB1 (NM_006253)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAB1
    Primer
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    OriGene qPCR primer pairs and template standards for PRKAB1
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKAB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKAB1
      QuantiTect SYBR Green Assays in human, mouse, rat PRKAB1
      QuantiFast Probe-based Assays in human, mouse, rat PRKAB1

    Selected AceView cDNA sequences (see all 374):

    BP335583 CB118918 AA424210 AI569342 BQ927263 AA496156 BE906675 N58031 
    AI423363 AI304758 BM457673 BM711001 AA513407 R62467 AA746301 AI304468 
    CN482427 AW512746 AI630549 BI821335 BC001007 AA442315 AI567594 AA330964 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRKAB1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
    SP1:                                -     -                 -                             -     -                           
    SP2:                    -           -     -                 -                                                               
    SP3:                                                        -                                                               
    SP4:                                -     -                 -     -     -                                                   
    SP5:                                      -                                                                                 


    ECgene alternative splicing isoforms for PRKAB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRKAB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCTGCTC
    PRKAB1 Expression
    About this image


    PRKAB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PRKAB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKAB1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAB1: 
              mTOR Signaling in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Prostate Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKAB1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkab11 , 5 protein kinase, AMP-activated, beta 1 non-catalytic more1, 5 89.14(n)1
    96.67(a)1
      5 (56.10 cM)5
    190791  NM_031869.21  NP_114075.11 
     1160135865 
    chicken
    (Gallus gallus)
    Aves PRKAB11 protein kinase, AMP-activated, beta 1 non-catalytic more 82.4(n)
    92.57(a)
      416986  NM_001039912.1  NP_001035001.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAB16
    protein kinase, AMP-activated, beta 1 non-catalyti...
    92(a)
    1 ↔ 1
    GL343338.1(267507-272525)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD328675.12   -- 77.06(n)    CD328675.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.141262 Transcribed sequence with moderate similarity to protein more 77.44(n)    CK028313.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80573
    alc1
    SNF1A/AMP-activated protein kinase3
    alicorn1
    62(a)3
    61.88(n)1
    64.89(a)1
      45A113
    359311  NM_136616.41  NP_610460.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F55F3.13   -- 46(a)
    (best of 2)
      X(13791061-13793948)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SIP26
    GAL836
    One of three beta subunits of the Snf1 serine/thre...
    One of three possible beta-subunits of the Snf1 ki...
    20(a)
    19(a)
    many ↔ many
    many ↔ many
    VII(97338-98585) YGL208W
    V(208979-210232) YER027C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G163601 AT4G16360 50.09(n)
    40.44(a)
      827331  NM_001036573.5  NP_001031650.2 


    ENSEMBL Gene Tree for PRKAB1 (if available)
    TreeFam Gene Tree for PRKAB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRKAB1 gene
    PRKAB22  
    1 SIMAP similar gene for PRKAB1 using alignment to 4 protein entries:     AAKB1_HUMAN (see all proteins):
    PRKAB2

    PRKAB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRKAB1 (see all 345)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486414471,2
    --120103768(+) CAACAC/TTTCTG 1 -- us2k10--------
    rs562155411,2
    C,F--120103816(+) TCAGGA/GAGACC 1 -- us2k12Minor allele frequency- G:0.04WA 120
    rs1854109231,2
    --120103851(+) GGCTCC/TCATCC 1 -- us2k10--------
    rs1420460951,2
    --120103935(+) GTGGGC/TCGGTG 1 -- us2k10--------
    rs1477788191,2
    C--120104104(+) CTCCTC/GTCCCC 1 -- us2k10--------
    rs1157470371,2
    --120104128(+) ATTAAC/GAATGT 1 -- us2k10--------
    rs1897742361,2
    --120104165(+) TTTGCC/TAGCCT 1 -- us2k10--------
    rs37594001,2
    C,F,H--120104173(-) GCACTA/GTTAGG 1 -- us2k19Minor allele frequency- G:0.04EA NS NA 560
    rs1819676081,2
    --120104194(+) GTTAAC/TAGTTA 1 -- us2k10--------
    rs1410051901,2
    --120104248(+) TGCACA/GTTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRKAB1 (120105558 - 120119435 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRKAB1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKAB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602740    OMIM disorders: --

    Selected diseases for PRKAB1 (see all 54):    
    About MalaCards
    fumarate hydratase deficiency    krabbe disease    lafora disease    anoxia
    kidney cancer    tauopathy    friedreich ataxia    hyperglycemia
    fatty liver disease    tuberous sclerosis    maturity-onset diabetes of the young    cushing's syndrome
    cytomegalovirus infection    mantle cell lymphoma    hypertrophic cardiomyopathy    vascular disease
    insulin resistance    epididymitis    b-cell chronic lymphocytic leukemia    ischemia


    PRKAB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PRKAB1 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin sensitivity 59.6 28 16634986 (2), 15033479 (2), 17208384 (2), 15230153 (1) (see all 16)
    obesity 54.4 15 19138981 (1), 16622294 (1), 17021375 (1), 17144168 (1) (see all 12)
    insulin resistance 51.5 5 16709632 (2), 15681023 (1), 16054041 (1)
    metabolic disorder 51.4 6 19628050 (1), 17144168 (1), 17496363 (1), 17026483 (1) (see all 6)
    hyperinsulinemia 35.8 3 19100718 (1), 19136982 (1)
    colon cancer 32.1 23 17404062 (4), 16797120 (4), 17047069 (3), 17341607 (2) (see all 10)
    cancer 28 46 17404056 (5), 15681023 (3), 16797120 (3), 19093868 (3) (see all 20)
    hyperglycemia 24.4 2 10866040 (1), 19635557 (1)
    vascular diseases 17.5 2 16636195 (1), 16151020 (1)
    necrosis 16.4 1 17513605 (1)

    Genetic Association Database (GAD): PRKAB1
    Human Genome Epidemiology (HuGE) Navigator: PRKAB1 (11 documents)

    Export disorders for PRKAB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRKAB1 gene, integrated from 10 sources (see all 490):
    (articles sorted by number of sources associating them with PRKAB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. (PubMed id 21460634)1, 2 Loffler A.S.... Stork B. (Autophagy 2011)
    2. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PubMed id 20682687)1, 4 Jablonski K.A....Florez J.C. (Diabetes 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    5. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    6. Identification and characterization of a novel folliculin-interacting protein FNIP2. (PubMed id 18403135)1, 2 Hasumi H.... Schmidt L.S. (Gene 2008)
    7. AMP-activated protein kinase in metabolic control and insulin signaling. (PubMed id 17307971)2, 7 Towler M.C. and Hardie D.G. (Circ. Res. 2007)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    9. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PubMed id 17028174)1, 2 Baba M.... Zbar B. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5564 HGNC: 9378 AceView: PRKAB1 Ensembl:ENSG00000111725 euGenes: HUgn5564
    ECgene: PRKAB1 Kegg: 5564 H-InvDB: PRKAB1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRKAB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRKAB1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRKAB1 gene:
    Search GeneIP for patents involving PRKAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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