Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PRKAA1 Gene

protein-coding   GIFtS: 68
GCID: GC05M040759

Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Protein Kinase, AMP-Activated, Alpha 1 Catalytic Subunit1 2     5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-12
AMPK1 2     5'-AMP-Activated Protein Kinase, Catalytic Alpha-1 Chain2
Acetyl-CoA Carboxylase Kinase2 3     AMPKa12
Hydroxymethylglutaryl-CoA Reductase Kinase2 3     AMP -Activate Kinase Alpha 1 Subunit2
Tau-Protein Kinase PRKAA12 3     AMP-Activated Protein Kinase, Catalytic, Alpha-12
ACACA Kinase2 3     AMPK Alpha 12
AMPK Subunit Alpha-12 3     AMPK13
HMGCR Kinase2 3     EC 2.7.11.263
EC 2.7.11.13 8     EC 2.7.11.273
11     EC 2.7.11.313
alpha1     EC 2.7.118

External Ids:    HGNC: 93761   Entrez Gene: 55622   Ensembl: ENSG000001323567   OMIM: 6027395   UniProtKB: Q131313   

Export aliases for PRKAA1 gene to outside databases

Previous GC identifers: GC05M041069 GC05M041854 GC05M040804 GC05M040795 GC05M040711


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PRKAA1 Gene:
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the
5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells.
The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates
the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that
cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript
variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRKAA1 Gene:
PRKAA1 (protein kinase, AMP-activated, alpha 1 catalytic subunit) is a protein-coding gene. Diseases associated with PRKAA1 include wolff-parkinson-white syndrome, and autoimmune disease of central nervous system. GO annotations related to this gene include chromatin binding and protein C-terminus binding. An important paralog of this gene is STK40.

UniProtKB/Swiss-Prot: AAPK1_HUMAN, Q13131
Function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a
key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK
activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic
enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of
cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid
synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE;
regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and
hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by
phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation
of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of
TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators
involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A,
p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating
CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates
'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and
proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively
regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and
activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating
ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to
destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also
has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2,
leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also
phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1

summary for PRKAA1 Gene:
AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of
alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of
cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to
stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis.
The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by
phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by
calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates
allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in
metabolically active tissues such as the skeletal muscles and liver.

Gene Wiki entry for PRKAA1 (Protein kinase, AMP-activated, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRKAA1 gene promoter:
         STAT1   AP-1   Egr-1   ATF-2   Nkx2-5   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRKAA1 promoter sequence
   Search Chromatin IP Primers for PRKAA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p12   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

PRKAA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRKAA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M040759:  view genomic region     (about GC identifiers)

Start:
40,759,481 bp from pter      End:
40,798,476 bp from pter
Size:
38,996 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AAPK1_HUMAN, Q13131 (See protein sequence)
Recommended Name: 5'-AMP-activated protein kinase catalytic subunit alpha-1  
Size: 559 amino acids; 64009 Da
Cofactor: Magnesium
Subunit: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a
gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2
Sequence caution: Sequence=AAA64850.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD43027.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH37303.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA36547.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG35788.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A8MTQ6 B2R7E1 O00286 Q5D0E1 Q86VS1 Q9UNQ4
Alternative splicing: 2 isoforms:  Q13131-1   Q13131-2   

Explore the universe of human proteins at neXtProt for PRKAA1: NX_Q13131

Explore proteomics data for PRKAA1 at MOPED

Post-translational modifications: 

  • Ubiquitinated (By similarity)1
  • Phosphorylated at Thr-183 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39. Also phosphorylated at Thr-183 by CAMKK2; triggered by a rise in intracellular calcium ions, without
    detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-183, but at a much lower level.
    Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1 and ULK2; leading to
    negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2
    and AMPK. Dephosphorylated by PPM1A and PPM1B1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRKAA1 (Q13131) (see all 32)
     VVHRDLK  KRATIKD  QDPLAVA  LAVAYHL 


    See PRKAA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006242.5  NP_996790.3  

    ENSEMBL proteins: 
     ENSP00000380317   ENSP00000346148   ENSP00000296800  
    Reactome Protein details: Q13131

    PRKAA1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant PRKAA1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PRKAA1
    OriGene Protein Over-expression Lysate for PRKAA1
    OriGene MassSpec for PRKAA1
    OriGene Custom Protein Services for PRKAA1
    GenScript Custom Purified and Recombinant Proteins Services for PRKAA1
    Novus Biologicals PRKAA1 Proteins
    Novus Biologicals PRKAA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PRKAA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKAA1
    R&D Systems Antibodies for PRKAA1 (AMPK alpha 1)
    Cell Signaling Technology (CST) Antibodies for PRKAA1  (AMPKA1)
    OriGene Antibodies for PRKAA1
    OriGene Custom Antibody Services for PRKAA1
    Novus Biologicals PRKAA1 Antibodies
    Abcam antibodies for PRKAA1 (P49642, Q13131, P54646)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for PRKAA1
    LSBio Antibodies in human, mouse, rat for PRKAA1

    PRKAA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRKAA1
    R&D Systems ELISAs for PRKAA1 (AMPK alpha 1)         (see all)
    GenScript Custom Assay Services for PRKAA1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for PRKAA1 (AMPKA1)
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, AMP-activated, alpha 1 catalytic subunit
    AMPK subfamily
    Selected non-AGC protein kinase activities

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR028375 KA1/Ssp2_C

    Graphical View of Domain Structure for InterPro Entry Q13131

    ProtoNet protein and cluster: Q13131

    UniProtKB/Swiss-Prot: AAPK1_HUMAN, Q13131
    Domain: The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated
    domains and represses kinase activity
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain


    PRKAA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AAPK1_HUMAN, Q13131
    Function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a
    key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK
    activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
    lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic
    enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of
    cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid
    synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE;
    regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and
    hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by
    phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation
    of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of
    TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators
    involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A,
    p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating
    CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates
    'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and
    proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively
    regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and
    activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating
    ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to
    destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also
    has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2,
    leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also
    phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Catalytic activity: ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA
    reductase (NADPH)] phosphate
    Catalytic activity: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate
    Enzyme regulation: Activated by phosphorylation on Thr-183. Binding of AMP to non-catalytic gamma subunit (PRKAG1,
    PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-183. AMP-binding to gamma
    subunit also sustains activity by preventing dephosphorylation of Thr-183. ADP also stimulates Thr-183
    phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-183,
    rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex
    with ATP, which is much more abundant than AMP. AMPK is activated by antihyperglycemic drug metformin, a drug
    prescribed to patients with type 2 diabetes: in vivo, metformin seems to mainly inhibit liver gluconeogenesis.
    However, metformin can be used to activate AMPK in muscle and other cells in culture or ex vivo
    (PubMed:11602624). Selectively inhibited by compound C
    (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a
    natural polyphenol present in red wine, and S17834, a synthetic polyphenol

         Genatlas biochemistry entry for PRKAA1:
    protein kinase,cAMP activated,alpha 1 catalytic subunit,involved in fatty acid and cholesterol metabolism

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261 EC 2.7.11.271 EC 2.7.11.311

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding ISS--
    GO:0004672protein kinase activity IDA17028174
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004679AMP-activated protein kinase activity IDA18439900
    GO:0004691cAMP-dependent protein kinase activity NAS8557660
         
    PRKAA1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prkaa1):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     muscle 

    PRKAA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKAA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKAA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRKAA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRKAA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRKAA1:
    hsa-mir-652-3p (MIRT039458), hsa-mir-130b-3p (MIRT020218), hsa-mir-30e-5p (MIRT044135), hsa-mir-29b-3p (MIRT048377), hsa-mir-30a-5p (MIRT028534), hsa-mir-128-3p (MIRT021937), hsa-mir-148b-3p (MIRT019393), hsa-mir-19b-3p (MIRT006742)

    Block miRNA regulation of human, mouse, rat PRKAA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKAA1 (see all 90):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-218-1* hsa-miR-3074-3p hsa-miR-519a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidPRKAA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRKAA1
    Predesigned siRNA for gene silencing in human, mouse, rat PRKAA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRKAA1

    Clone
    Products:
         
    OriGene clones in human, mouse for PRKAA1 (see all 16)
    OriGene ORF clones in mouse, rat for PRKAA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKAA1 (NM_206907)
    Sino Biological Human cDNA Clone for PRKAA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKAA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRKAA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRKAA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AAPK1_HUMAN, Q13131: Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC8557660
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016324apical plasma membrane IEA--

    PRKAA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PRKAA1 About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    Signaling by Insulin receptor0.80
    IRS-related events0.94
    PKB-mediated events0.41
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    mTOR signalling0.39
    IRS-mediated signalling0.92
    TOR signaling0.32
    2Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    Regulation of CFTR gating normal and CF 0.00
    3Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    Insulin signaling pathway0.32
    4Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PRKAA1
        Adipocytokines & Insulin Signaling

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRKAA1
        AMPK Enzyme Complex Pathway
    eNOS Signaling
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for PRKAA1
        Glucose / Energy Metabolism

    1 Tocris Bioscience Pathway for PRKAA1
        mTOR Pathway

    3 GeneGo (Thomson Reuters) Pathways for PRKAA1
        Regulation of CFTR gating (normal and CF)
    Regulation of CFTR activity (norm and CF)
    Development Leptin signaling via PI3K-dependent pathway

    Selected BioSystems Pathways for PRKAA1 (see all 6)
        TOR signaling
    Insulin Signaling
    AMPK signaling
    BDNF signaling pathway
    SREBF and miR33 in cholesterol and lipid homeostasis


    2 Reactome Pathways for PRKAA1
        Regulation of Rheb GTPase activity by AMPK
    Regulation of AMPK activity via LKB1

    1 PharmGKB Pathway for PRKAA1
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for PRKAA1) (see all 10):
        FoxO signaling pathway
    Regulation of autophagy
    mTOR signaling pathway
    PI3K-Akt signaling pathway
    Circadian rhythm


    PRKAA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAA1 (see all 8): 
              mTOR Signaling in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Autophagy in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRKAA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRKAA1 (Q131311, 2, 3 ENSP000003461484) via UniProtKB, MINT, STRING, and/or I2D (see all 582)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity NAS11546797
    GO:0001666response to hypoxia NAS8557660
    GO:0006006glucose metabolic process IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    PRKAA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PRKAA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    A 769662Potent AMPK activator[844499-71-4]
    Dorsomorphin dihydrochloridePotent and selective AMPK inhibitor[1219168-18-9]
    Metformin hydrochlorideActivator of LKB1/AMPK; antidiabetic agent[1115-70-4]
    PT 1AMPK activator[331002-70-1]

    Selected HMDB Compounds for PRKAA1 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Glucosylceramide (d18:1/12:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    Glucosylceramide (d18:1/16:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    Glucosylceramide (d18:1/18:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    Glucosylceramide (d18:1/20:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    Glucosylceramide (d18:1/22:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    Glucosylceramide (d18:1/24:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--
    Glucosylceramide (d18:1/25:0)1-O-b-D-glucopyranosyl-Ceramide (see all 8)85305-87-9--

    3 DrugBank Compounds for PRKAA1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PhenforminBeta-Pebg (see all 17)114-86-3targetactivator17369473 17603555 17995453
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetactivator17167165

    Selected Novoseek inferred chemical compound relationships for PRKAA1 gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acadesine 73.5 7 18798311 (3), 12417310 (1), 12145153 (1), 12208500 (1)
    metformin 72.2 65 14871885 (5), 18484962 (5), 12145153 (5), 18721796 (4) (see all 25)
    atp 68 107 18563357 (3), 17974626 (3), 16027121 (3), 17039396 (2) (see all 50)
    fatty acid 62.7 48 17997341 (3), 17500064 (2), 19245653 (2), 14641016 (2) (see all 28)
    phenformin 62.2 5 15919715 (4), 20444419 (1)
    rapamycin 60.6 7 18827172 (1), 19092695 (1), 18343152 (1), 19507259 (1) (see all 7)
    glucose 57.3 98 11467861 (4), 14532293 (4), 18563357 (3), 17974626 (3) (see all 52)
    aicar 57 6 15919715 (3), 16382178 (1), 11509501 (1)
    acetyl-coa 54.9 9 18297106 (2), 16868748 (1), 16990341 (1), 16434556 (1) (see all 7)
    threonine 48.5 17 9003365 (2), 19818314 (1), 15058305 (1), 11284715 (1) (see all 16)



    PRKAA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PRKAA1 gene (2 alternative transcripts): 
    NM_006251.5  NM_206907.3  

    Unigene Cluster for PRKAA1:

    Protein kinase, AMP-activated, alpha 1 catalytic subunit
    Hs.43322  [show with all ESTs]
    Unigene Representative Sequence: NM_206907
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397128(uc003jmb.3 uc003jmc.3) ENST00000354209 ENST00000513152
    ENST00000505783 ENST00000506652 ENST00000509874 ENST00000296800 ENST00000511248
    ENST00000397006
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRKAA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRKAA1 (see all 90):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-218-1* hsa-miR-3074-3p hsa-miR-519a hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidPRKAA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRKAA1
    Predesigned siRNA for gene silencing in human, mouse, rat PRKAA1
    Clone
    Products:
         
    OriGene clones in human, mouse for PRKAA1 (see all 16)
    OriGene ORF clones in mouse, rat for PRKAA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRKAA1 (NM_206907)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRKAA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKAA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKAA1
      QuantiTect SYBR Green Assays in human, mouse, rat PRKAA1
      QuantiFast Probe-based Assays in human, mouse, rat PRKAA1

    Additional mRNA sequence: 

    AB022017.1 AF100763.1 AK307546.1 AK312947.1 BC012622.1 BC037303.2 BC048980.1 U22456.1 
    Y12856.1 

    14 DOTS entries:

    DT.442118  DT.100688995  DT.100679863  DT.91884113  DT.120806759  DT.95236846  DT.120806707  DT.95167837 
    DT.422360  DT.120806740  DT.91760022  DT.120806706  DT.95167838  DT.120806753 

    Selected AceView cDNA sequences (see all 205):

    BM759185 AI681997 AA604847 AA358109 BQ878361 BG743416 BU520965 H88254 
    BI495203 CD512594 AA843482 AA320710 BX089121 AW297246 AI935917 BM978221 
    AA333406 AA353504 AA602934 AA846651 BX494823 BM977269 BQ049192 AA889486 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRKAA1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                -     -                             -                                                   
    SP2:                                -     -           -                 -                                                   
    SP3:                          -     -     -                             -                                                   
    SP4:                                -     -           -                                                                     
    SP5:                          -     -     -           -                 -                                                   


    ECgene alternative splicing isoforms for PRKAA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PRKAA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PRKAA1 Expression
    About this image


    PRKAA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PRKAA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRKAA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43322
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRKAA1 (see all 8): 
              mTOR Signaling in human mouse rat
              Fatty Acid Metabolism in human mouse rat
              Autophagy in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PRKAA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKAA1
    QuantiTect SYBR Green Assays in human, mouse, rat PRKAA1
    QuantiFast Probe-based Assays in human, mouse, rat PRKAA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRKAA1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prkaa11 , 5 protein kinase, AMP-activated, alpha 1 catalytic subunit1, 5 90.22(n)1
    98.75(a)1
      15 (1.99 cM)5
    1057871  NM_001013367.31  NP_001013385.31 
     51438615 
    chicken
    (Gallus gallus)
    Aves PRKAA11 protein kinase, AMP-activated, alpha 1 catalytic subunit 85.01(n)
    95.52(a)
      427185  NM_001039603.1  NP_001034692.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRKAA16
    protein kinase, AMP-activated, alpha 1 catalytic s...
    94(a)
    1 ↔ 1
    2(6966585-7007886)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52512 Xenopus laevis SNF1-like protein AMPK mRNA, complete more 80.29(n)    AF340021.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prkaa12 protein kinase, AMP-activated, alpha 1 catalytic subunit 78.11(n)   368268  BI476044.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SNF1A6
    SNF1A/AMP-activated protein kinase
    57(a)
    1 → many
    X(1269580-1272890)
    worm
    (Caenorhabditis elegans)
    Secernentea T01C8.1a3 ser/thr-protein kinase 58(a)
    (best of 5)
      X(16830550-16833650)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNF16
    AMP-activated serine/threonine protein kinase foun...
    36(a)
    1 → many
    IV(1412373-1414274) YDR477W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons KIN101 KIN10 58.23(n)
    56.58(a)
      821259  NM_110974.4  NP_566130.1 
    rice
    (Oryza sativa)
    Liliopsida Os.33932 Oryza sativa mRNA for OSK1, complete cds 73.84(n)    AK069613.1 


    ENSEMBL Gene Tree for PRKAA1 (if available)
    TreeFam Gene Tree for PRKAA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PRKAA1 gene
    STK402  TRIB32  NUAK12  PRKAA22  HUNK2  TRIB12  NUAK22  TRIB22  
    MELK2  
    Selected SIMAP similar genes for PRKAA1 using alignment to 2 protein entries:     AAPK1_HUMAN (see all proteins) (see all similar genes):
    PRKAA2    MARK4    NUAK1    SIK2    BRSK1    SIK1
    BRSK2    KIAA0999    SIK3    HUNK    MARK1    MARK2
    MELK    DCLK1    DAPK3    PNCK    DAPK1    SNRK

    PRKAA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PRKAA1 (see all 812)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0356224
    A breast cancer sample4--see VAR_0356222 Q R mis40--------
    rs1404276301,2
    C--40759005(+) CATGTA/CGTCGA 2 -- ds50010--------
    rs1894311461,2
    --40759014(+) GAGATA/GAAAAT 2 -- ds50010--------
    rs297411,2
    C,F--40759034(-) TTAAAT/CTGTCA 2 -- ds50011Minor allele frequency- C:0.00NA 2
    rs297401,2
    C,F,A,H--40759127(-) GGCAAC/AAGAGT 2 -- ds50017Minor allele frequency- A:0.28NA WA CSA EA 364
    rs1818000591,2
    --40759226(+) AGGTGG/TGACTA 2 -- ds50010--------
    rs1132785361,2
    C,F--40759261(+) TAATTG/TTTGTG 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1845526961,2
    --40759291(+) TTCACC/TATGTT 2 -- ds50010--------
    rs1889646661,2
    C--40759333(+) TGATCC/TACCCA 2 -- ds50010--------
    rs1813374241,2
    C--40759349(+) GCCTCA/CCACAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for PRKAA1 (40759481 - 40798476 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRKAA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675082CNV Deletion23128226
    esv2671114CNV Deletion23128226
    esv2730120CNV Deletion23290073
    nsv880438CNV Loss21882294
    dgv6040n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRKAA1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRKAA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602739    OMIM disorders: --

    Selected diseases for PRKAA1 (see all 51):    
    About MalaCards
    wolff-parkinson-white syndrome    autoimmune disease of central nervous system    lafora disease    insulinoma
    tuberous sclerosis    hypoglycemia    morbid obesity    fatty liver disease
    hypertrophic cardiomyopathy    epididymitis    age related macular degeneration    obesity
    vasculitis    retinal degeneration    insulin resistance    liver disease
    hypoxia    huntington's disease    cystic fibrosis    ischemia


    PRKAA1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PRKAA1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    obesity 43.2 11 18719601 (2), 16508085 (1), 17438370 (1), 16644802 (1) (see all 8)
    insulin sensitivity 42.5 3 17485446 (1), 17869249 (1), 17530314 (1), 16434556 (1)
    tuberous sclerosis 41.3 1 19520853 (1)
    insulin resistance 37.9 6 15694373 (1), 17438370 (1), 19273380 (1), 18430992 (1) (see all 5)
    insulinoma 30.4 2 14871885 (1), 20206170 (1)
    cardiac hypertrophy 28.1 4 15759047 (2), 12397075 (1)
    wolff-parkinson-white syndrome 20.2 1 12397075 (1)
    cancer 18.8 23 19778642 (3), 19221486 (2), 19243571 (2), 19723334 (1) (see all 13)
    cardiovascular diseases 0 3 16597407 (1), 20060780 (1)
    ischemia 0 3 19359670 (1), 17556544 (1), 12960015 (1)

    Genetic Association Database (GAD): PRKAA1
    Human Genome Epidemiology (HuGE) Navigator: PRKAA1 (14 documents)

    Export disorders for PRKAA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PRKAA1 gene, integrated from 10 sources (see all 451):
    (articles sorted by number of sources associating them with PRKAA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian AMP-activated protein kinase subfamily. (PubMed id 8557660)1, 2, 3 Stapleton D.... Kemp B.E. (J. Biol. Chem. 1996)
    2. TSC2 mediates cellular energy response to control cell growth and survival. (PubMed id 14651849)1, 2, 9 Inoki K.... Guan K.L. (Cell 2003)
    3. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. (PubMed id 22037551)1, 4 Shi Y....Shen H. (Nat. Genet. 2011)
    4. Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. (PubMed id 20682687)1, 4 Jablonski K.A....Florez J.C. (Diabetes 2010)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1. (PubMed id 20622004)1, 4 Slattery M.L....Wolff R.K. (Carcinogenesis 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    9. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)1, 4 RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
    10. AMPK phosphorylation of raptor mediates a metabolic checkpoint. (PubMed id 18439900)1, 2 Gwinn D.M.... Shaw R.J. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5562 HGNC: 9376 AceView: PRKAA1 Ensembl:ENSG00000132356 euGenes: HUgn5562
    ECgene: PRKAA1 Kegg: 5562 H-InvDB: PRKAA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PRKAA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRKAA1 gene:
    Search GeneIP for patents involving PRKAA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRKAA1
     EMD Millipore Purified and/or Recombinant PRKAA1 Protein
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for PRKAA1 (AMPK alpha 1)   Browse Cell Culture Products  
     ELISAs for PRKAA1 (AMPK alpha 1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for PRKAA1 (AMPK alpha 1)  
     OriGene Antibodies for PRKAA1   OriGene RNAi products in human, mouse, rat for PRKAA1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PRKAA1  
     OriGene MassSpec something-or-other for PRKAA1   OriGene clones in human, mouse for PRKAA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRKAA1   OriGene Purified Protein for PRKAA1  
     OriGene ORF clones in mouse, rat for PRKAA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRKAA1   OriGene Custom Protein Services for PRKAA1  

     
     
     Block miRNA regulation of human, mouse, rat PRKAA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRKAA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRKAA1 Predesigned siRNA for gene silencing in human, mouse, rat PRKAA1
     QuantiFast Probe-based Assays in human, mouse, rat PRKAA1 QuantiTect SYBR Green Assays in human, mouse, rat PRKAA1
     PCR Arrays including human, mouse, rat PRKAA1 Search Chromatin IP Primers for PRKAA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRKAA1  GeneGlobe Interaction Network for PRKAA1
     Regulatory tfbs in PRKAA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PRKAA1 GenScript cDNA clones with any tag delivered in your preferred vector for PRKAA1
     GenScript Custom Assay Services for PRKAA1 GenScript Custom overexpressing Cell Line Services for PRKAA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for PRKAA1  (AMPKA1)

     Tocris compounds for PRKAA1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PRKAA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PRKAA1 antibodies
     PRKAA1 proteins
     PRKAA1 lysates
     Antibodies for PRKAA1
     See all of Abcam's Antibodies, Kits and Proteins for PRKAA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRKAA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRKAA1
     SwitchGear 3'UTR luciferase reporter plasmids for PRKAA1
     SwitchGear Promoter luciferase reporter plasmids for PRKAA1
     ThermoFisher Antibody for PRKAA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRKAA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRKAA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRKAA1
     LSBio Antibodies in human, mouse, rat for PRKAA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRKAA1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4