Aliases for PRIMPOL Gene
External Ids for PRIMPOL Gene
Previous HGNC Symbols for PRIMPOL Gene
Previous GeneCards Identifiers for PRIMPOL Gene
GeneCards Summary for PRIMPOL Gene
PRIMPOL (Primase And Polymerase (DNA-Directed)) is a Protein Coding gene. Diseases associated with PRIMPOL include myopia 22, autosomal dominant and myopia. GO annotations related to this gene include chromatin binding and DNA-directed DNA polymerase activity.
UniProtKB/Swiss-Prot for PRIMPOL Gene
DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.