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Aliases for PRIMA1 Gene

Aliases for PRIMA1 Gene

  • Proline Rich Membrane Anchor 1 2 3 5
  • PRIMA 3 4
  • Acetylcholinesterase Membrane Anchor Precursor PRiMA 3
  • Membrane Anchor Of Acetylcholinesterase 2

External Ids for PRIMA1 Gene

Previous GeneCards Identifiers for PRIMA1 Gene

  • GC14U990462
  • GC14M092176
  • GC14M092178
  • GC14M092179
  • GC14M093258
  • GC14M094184
  • GC14M074364

Summaries for PRIMA1 Gene

Entrez Gene Summary for PRIMA1 Gene

  • The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]

GeneCards Summary for PRIMA1 Gene

PRIMA1 (Proline Rich Membrane Anchor 1) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and protein anchor.

UniProtKB/Swiss-Prot for PRIMA1 Gene

  • Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity).

Gene Wiki entry for PRIMA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRIMA1 Gene

Genomics for PRIMA1 Gene

Regulatory Elements for PRIMA1 Gene

Enhancers for PRIMA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRIMA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRIMA1 Gene

93,718,298 bp from pter
93,789,035 bp from pter
70,738 bases
Minus strand

Genomic View for PRIMA1 Gene

Genes around PRIMA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRIMA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRIMA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRIMA1 Gene

Proteins for PRIMA1 Gene

  • Protein details for PRIMA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich membrane anchor 1
    Protein Accession:
    Secondary Accessions:
    • Q86XR6

    Protein attributes for PRIMA1 Gene

    153 amino acids
    Molecular mass:
    16689 Da
    Quaternary structure:
    • Interacts with ACHE, probably through disulfide bonds.

    Alternative splice isoforms for PRIMA1 Gene


neXtProt entry for PRIMA1 Gene

Proteomics data for PRIMA1 Gene at MOPED

Post-translational modifications for PRIMA1 Gene

  • Glycosylation at Asn 79
  • Modification sites at PhosphoSitePlus

Other Protein References for PRIMA1 Gene

No data available for DME Specific Peptides for PRIMA1 Gene

Domains & Families for PRIMA1 Gene

Protein Domains for PRIMA1 Gene


Suggested Antigen Peptide Sequences for PRIMA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.
  • The proline-rich attachment domain (PRAD) binds the AChE catalytic subunits.
  • Contains 1 PRAD (Pro-rich attachment) domain.
genes like me logo Genes that share domains with PRIMA1: view

No data available for Gene Families for PRIMA1 Gene

Function for PRIMA1 Gene

Molecular function for PRIMA1 Gene

UniProtKB/Swiss-Prot Function:
Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity).
UniProtKB/Swiss-Prot Induction:
By RAF1.
genes like me logo Genes that share phenotypes with PRIMA1: view

Animal Models for PRIMA1 Gene

MGI Knock Outs for PRIMA1:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRIMA1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRIMA1 Gene

Localization for PRIMA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRIMA1 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, synapse. Note=In the brain, PRIMA linked to ACHE is found in membrane rafts. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PRIMA1 Gene COMPARTMENTS Subcellular localization image for PRIMA1 gene
Compartment Confidence
plasma membrane 4
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRIMA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PRIMA1: view

Pathways & Interactions for PRIMA1 Gene

SuperPathways for PRIMA1 Gene

No Data Available

Interacting Proteins for PRIMA1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000376848 Q86XR5-PRIMA_HUMAN for PRIMA1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PRIMA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PRIMA1 Gene

Drugs & Compounds for PRIMA1 Gene

No Compound Related Data Available

Transcripts for PRIMA1 Gene

Unigene Clusters for PRIMA1 Gene

Proline rich membrane anchor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRIMA1 Gene

No ASD Table

Relevant External Links for PRIMA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRIMA1 Gene

mRNA expression in normal human tissues for PRIMA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRIMA1 Gene

This gene is overexpressed in Nerve - Tibial (x8.0) and Colon - Sigmoid (x4.5).

SOURCE GeneReport for Unigene cluster for PRIMA1 Gene Hs.432401

genes like me logo Genes that share expression patterns with PRIMA1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRIMA1 Gene

Orthologs for PRIMA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRIMA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRIMA1 35
  • 82.87 (n)
  • 81.25 (a)
  • 81 (a)
(Canis familiaris)
Mammalia PRIMA1 35
  • 90.63 (n)
  • 92.16 (a)
  • 92 (a)
(Mus musculus)
Mammalia Prima1 35
  • 86.71 (n)
  • 91.5 (a)
Prima1 16
Prima1 36
  • 92 (a)
(Pan troglodytes)
Mammalia PRIMA1 35
  • 93.9 (n)
  • 94.77 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Prima1 35
  • 86.93 (n)
  • 90.85 (a)
(Monodelphis domestica)
Mammalia PRIMA1 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia PRIMA1 36
  • 68 (a)
(Gallus gallus)
Aves PRIMA1 35
  • 77.41 (n)
  • 78.29 (a)
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prima1 35
  • 61.16 (n)
  • 61.74 (a)
(Danio rerio)
Actinopterygii PRIMA1 36
  • 48 (a)
Species with no ortholog for PRIMA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRIMA1 Gene

Gene Tree for PRIMA1 (if available)
Gene Tree for PRIMA1 (if available)

Paralogs for PRIMA1 Gene

No data available for Paralogs for PRIMA1 Gene

Variants for PRIMA1 Gene

Sequence variations from dbSNP and Humsavar for PRIMA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_035980 A colorectal cancer sample
rs7140229 -- 93,758,032(+) CAGAG(A/C)TACGG intron-variant
rs7141441 -- 93,767,054(+) CCTCA(C/T)GTCGC intron-variant
rs7142304 -- 93,767,384(+) CTGTG(G/T)ACCCT intron-variant
rs7494281 -- 93,766,361(+) tttgg(C/G)ccttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRIMA1 Gene

Variant ID Type Subtype PubMed ID
esv2749034 CNV Deletion 23290073
esv5239 CNV Deletion 18987735
esv2749035 CNV Deletion 23290073
esv259873 OTHER Complex 20981092
esv1465773 CNV Insertion 17803354
nsv524311 CNV Loss 19592680
nsv832861 CNV Loss 17160897
esv2749036 CNV Deletion 23290073
esv994901 CNV Deletion 20482838
esv1051201 CNV Deletion 17803354
nsv470658 CNV Gain 18288195

Variation tolerance for PRIMA1 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRIMA1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRIMA1 Gene

Disorders for PRIMA1 Gene

Relevant External Links for PRIMA1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRIMA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRIMA1 Gene

Publications for PRIMA1 Gene

  1. PRiMA: the membrane anchor of acetylcholinesterase in the brain. (PMID: 11804574) Perrier A.L. … Krejci E. (Neuron 2002) 2 3 4 23 67
  2. Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase. (PMID: 14622217) Perrier N.A. … MassouliAc J. (Eur. J. Neurosci. 2003) 3 23
  3. DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer. (PMID: 26482433) KalmA!r A. … MolnA!r B. (BMC Cancer 2015) 3
  4. PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53. (PMID: 23545415) Russo D. … Menichini P. (Biochim. Biophys. Acta 2013) 3
  5. N-linked glycosylation of proline-rich membrane anchor (PRiMA) is not required for assembly and trafficking of globular tetrameric acetylcholinesterase. (PMID: 22750213) Chan W.K. … Tsim K.W. (Neurosci. Lett. 2012) 3

Products for PRIMA1 Gene

Sources for PRIMA1 Gene