Aliases for PRIM2 Gene
External Ids for PRIM2 Gene
Previous HGNC Symbols for PRIM2 Gene
Previous GeneCards Identifiers for PRIM2 Gene
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
GeneCards Summary for PRIM2 Gene
PRIM2 (Primase (DNA) Subunit 2) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis and E2F mediated regulation of DNA replication. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and DNA primase activity.
UniProtKB/Swiss-Prot for PRIM2 Gene
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.