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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRIM2 Gene

protein-coding   GIFtS: 54
GCID: GC06P057179

primase, DNA, polypeptide 2 (58kDa)

(Previous names: primase, polypeptide 2A (58kD), primase, polypeptide 2A,...)
(Previous symbol: PRIM2A)
 Explore 1 disease affiliated with
PRIM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRIM2    

Aliases
for PRIM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Primase, DNA, Polypeptide 2 (58kDa)1 2     DJ422B11.1.11
PRIM2A1 2 3 5     DNA Primase Large Subunit2
DNA Primase 58 KDa Subunit2 3     DNA Primase Subunit P582
P581     Primase Polypeptide 2A, 58kDa2
Primase, Polypeptide 2A (58kD)1     EC 2.7.7.-3
Primase, Polypeptide 2A, 58kDa1     EC 2.7.78

External Ids:    HGNC: 93701   Entrez Gene: 55582   Ensembl: ENSG000001461437   OMIM: 1766365   UniProtKB: P496433   

Export aliases for PRIM2 gene to outside databases

Previous GC identifers: GC06P057287 GC06P057016


Summaries
for PRIM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRIM2:
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA
polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and
a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
The protein encoded by this gene is the large, 58 kDa primase subunit. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643
Function: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during
discontinuous DNA replication

Gene Wiki entry for PRIM2


Genomic Views
for PRIM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRIM2 gene promoter:
         Spz1   Pbx1a   ATF-2   STAT5A   E2F   COMP1   FOXJ2 (long isoform)   IRF-7A   STAT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRIM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRIM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12-p11.1   Ensembl cytogenetic band:  6p11.2   HGNC cytogenetic band: 6p12-p11.1

PRIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRIM2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P057179:  view genomic region     (about GC identifiers)

Start:
 57,179,603 bp from pter      End:
 57,513,376 bp from pter
Size:
 333,774 bases      Orientation:
 plus strand

Proteins
for PRIM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643 (See protein sequence)
Recommended Name: DNA primase large subunit  
Size: 509 amino acids; 58806 Da
Cofactor: Binds 1 4Fe-4S cluster
Subunit: Heterodimer of a small subunit and a large subunit
2 PDB 3D structures from and Proteopedia for PRIM2:
3L9Q (3D)        3Q36 (3D)    
Secondary accessions: Q53FJ8 Q6P1Q7 Q8WVL2 Q9H413
Alternative splicing: 2 isoforms:  P49643-1   P49643-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRIM2: NX_P49643

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49643

    • 2 DME Specific Peptides for PRIM2 (P49643)
     SHFILRLAYC  GKEGKRTDYTP 

    PRIM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000938.2  Reactome Protein details: P49643
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals PRIM2 Protein
    Novus Biologicals PRIM2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PRIM2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0030894replisome IEA--


    PRIM2 for ontologies           About GeneDecksing



    PRIM2 Antibody Products: 
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    Uscn Antibodies for PRIM2
    Search ThermoFisher Antibodies for PRIM2

    Assay Products for PRIM2: 
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    Uscn ELISAs and CLIAs for PRIM2

    Protein Domains /
    Families
    for PRIM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRIM2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007238 DNA_primase_lsu_euk/arc
     IPR016558 DNA_primase_lsu_euk

    Graphical View of Domain Structure for InterPro Entry P49643

    ProtoNet protein and cluster: P49643

    1 Blocks protein family: IPB007238 Eukaryotic-type DNA primase

    UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643
    Similarity: Belongs to the eukaryotic-type primase large subunit family


    Function
    for PRIM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643
    Function: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during
    discontinuous DNA replication

    Enzyme Numbers (IUBMB): EC 2.7.7.-1 EC 2.7.72

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRIM2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PRIM2:
    hsa-miR-495 hsa-miR-548p hsa-miR-198 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmid: PRIM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRIM2 (see all 7)
    OriGene shRNA RFP: PRIM2
    OriGene siRNA: PRIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRIM2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRIM2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRIM2 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PRIM2 (NM_000947)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRIM2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRIM2
    Search LifeMap BioReagents cell lines for PRIM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRIM2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003896DNA primase activity IEA--
    GO:0046872metal ion binding IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--


    PRIM2 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for PRIM2:
     Decreased Hepatitis C virus re  Decreased cell number and incr  Decreased number of cells in m  Decreased viability 


    Pathways & Interactions
    for PRIM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lagging Strand Synthesis
    8/13 pathways (see all 13)
    		Lagging Strand Synthesis1.00
    		Polymerase switching0.70
    		Telomere C-strand (Lagging Strand) Synthesis0.91
    		DNA strand elongation0.65
    		Extension of Telomeres0.83
    		DNA replication0.56
    		Processive synthesis on the lagging strand0.75
    		Processive synthesis on the leading strand0.45
    2Ubiquitinated Orc1 is degraded by the proteasome
    		DNA Replication Pre-Initiation0.62
    		DNA Replication0.49
    		M/G1 Transition0.62
    		S Phase0.40
    		Synthesis of DNA0.51
    3Cell cycle_Start of DNA replication in early S phase
    		Cell cycle_Start of DNA replication in early S phase1.00
    		Cell cycle Start of DNA replication in early S phase0.98
    4Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    5Activation of the pre-replicative complex
    		Activation of the pre-replicative complex1.00
    		DNA Replication0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for PRIM2
        Cell cycle Transition and termination of DNA replacation
    Cell cycle Start of DNA replication in early S phase
    Transcription Ligand-dependent activation of the ESR1/SP pathway


    1 Cell Signaling Technology (CST) Pathway for PRIM2
        Cell Cycle / Checkpoint Control

    3 GeneGo (Thomson Reuters) Pathways for PRIM2
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle Transition and termination of DNA replication
    Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for PRIM2 
        G1 to S cell cycle control
    DNA Replication

    5/27        Reactome Pathways for PRIM2 (see all 27)
        Extension of Telomeres
    Processive synthesis on the lagging strand
    Telomere Maintenance
    Leading Strand Synthesis
    Mitotic G1-G1/S phases


    4         Kegg Pathways  (Kegg details for PRIM2):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    DNA replication


    PRIM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRIM2

    5/42 Interacting proteins for PRIM2 (P496432, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPA1P276942, 3MINT-5223474 I2D: score=1 
    YWHAZP631042, 3MINT-3318368 I2D: score=1 
    PRIM1P496423I2D: score=8 
    POLA1P098843I2D: score=7 
    ARHGAP1Q079603I2D: score=5 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000216M/G1 transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--


    PRIM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRIM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRIM2
    Search CenterWatch for drugs/clinical trials and news about PRIM2 / PRI2 

    Transcripts
    for PRIM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRIM2 gene: 
    NM_000947.2  

    Unigene Cluster for PRIM2:

    Primase, DNA, polypeptide 2 (58kDa)
    Hs.654580  [show with all ESTs]
    Unigene Representative Sequence: NM_000947
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370687 ENST00000274891(uc003pdv.1) ENST00000389488(uc003pdx.3)
    ENST00000419977(uc003pdw.3) ENST00000490313 ENST00000470638 ENST00000550475


    miRNA
    Products:             		 OriGene 3'-UTR Clone: PRIM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRIM2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate PRIM2:
    hsa-miR-495 hsa-miR-548p hsa-miR-198 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmid: PRIM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRIM2 (see all 7)
    OriGene shRNA RFP: PRIM2
    OriGene siRNA: PRIM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRIM2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRIM2 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: PRIM2 (NM_000947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRIM2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRIM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRIM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRIM2

    Additional cDNA sequence: 

    AK223287.1 AK291915.1 BC017833.1 BC064931.1 X74331.1 XR_171580.1 

    10 DOTS entries:

    DT.91804401  DT.91933158  DT.75164719  DT.97842490  DT.91927290  DT.121389919  DT.40115500  DT.413688 
    DT.91762640  DT.40115501 

    24/97 AceView cDNA sequences (see all 97):

    BU187783 BP345363 BX280180 BI523986 AU253481 AA361880 BP355074 BP353860 
    BC017833 BM756079 BM852865 BP336097 AL556161 BM926617 AA255550 F10523 
    BP337854 BU193561 F12922 BM546142 R61796 BI907286 BP353433 BE246945 

    GeneLoc Exon Structure


    Expression
    for PRIM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACACTTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRIM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRIM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRIM2

    SOURCE GeneReport for Unigene cluster: Hs.654580
        SABiosciences Expression via Pathway-Focused PCR Array including PRIM2: 
              Neurotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRIM2

    Orthologs
    for PRIM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRIM2 gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Prim25 DNA primase, p58 subunit   --   1 (12.70 cM) 33453811 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.74592 Xenopus laevis transcribed sequence with weak similarity more 76.41(n)    CA982049.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii anxa1c2 Danio rerio clone RK137A2F09 primase, polypeptide 2A, more 72.06(n)    AY398398.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.113832 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.12(n)    AK064087.1 


    ENSEMBL Gene Tree for PRIM2 (if available)
    TreeFam Gene Tree for PRIM2 (if available) 

    Paralogs
    for PRIM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PRIM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 48 variations for PRIM2
         15/37 CNVs (see all 37): 22811 99552 44260 93743 36539 44262 23062 62520 6497 9531 99559 62521 99556 36537 99554
         10 Indels: 47135 40866 12845 47136 60595 12844 47134 62522 40867 40868
         1 Inversion: 59827
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRIM2

    Disorders / Diseases
    for PRIM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRIM2 for disorders           About GeneDecksing

    OMIM gene information: 176636    OMIM disorders: --

    1 disease for PRIM2:    About MalaCards
    malaria

    Human Genome Epidemiology (HuGE) Navigator: PRIM2 (1 document)

    Export disorders for PRIM2 gene to outside databases

    Publications
    for PRIM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRIM2 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with PRIM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. (PubMed id 8530050)1, 3, 9 Shiratori A....Miyazawa H. (1995)
    2. An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. (PubMed id 17893144)1, 2, 9 Weiner B.E....Chazin W.J. (2007)
    3. The genomic distribution and local context of coincide nt SNPs in human and chimpanzee. (PubMed id 20675616)1, 3 Hodgkinson A. and Eyre-Walker A. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. DNA replication in vitro by recombinant DNA-polymerase-alpha- primase. (PubMed id 8026492)1, 2 Stadlbauer F.... Nasheuer H.-P. (1994)
    7. Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180. (PubMed id 12220650)1, 9 Smith R.W. and Nasheuer H.P. (2002)
    8. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. (PubMed id 22437878)1 Chung J....Piedrahita J.A. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for PRIM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PRIM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5558 HGNC: 9370 AceView: PRIM2A Ensembl:ENSG00000146143 euGenes: HUgn5558
    ECgene: PRIM2 Kegg: 5558 H-InvDB: PRIM2

    Other Databases showing PRIM2 gene

    (According to HUGE)
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    Specialized Databases showing PRIM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRIM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRIM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRIM2 gene:
    Search GeneIP for patents involving PRIM2

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