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PRIM2 Gene

protein-coding   GIFtS: 58
GCID: GC06P057179

Primase, DNA, Polypeptide 2 (58kDa)

(Previous names: primase, polypeptide 2A (58kD), primase, polypeptide 2A,...)
(Previous symbol: PRIM2A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Primase, DNA, Polypeptide 2 (58kDa)1 2     DNA Primase Large Subunit2
PRIM2A1 2 3 5     DNA Primase Subunit P582
DNA Primase 58 KDa Subunit2 3     Primase Polypeptide 2A, 58kDa2
p582 3     EC 2.7.7.-3
Primase, Polypeptide 2A (58kD)1     EC 2.7.78
Primase, Polypeptide 2A, 58kDa1     

External Ids:    HGNC: 93701   Entrez Gene: 55582   Ensembl: ENSG000001461437   OMIM: 1766365   UniProtKB: P496433   

Export aliases for PRIM2 gene to outside databases

Previous GC identifers: GC06P057287 GC06P057016


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRIM2 Gene:
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of
DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a
DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the
lagging strand of the DNA. (provided by RefSeq, Sep 2013)

GeneCards Summary for PRIM2 Gene:
PRIM2 (primase, DNA, polypeptide 2 (58kDa)) is a protein-coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and DNA primase activity.

UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643
Function: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during
discontinuous DNA replication

Gene Wiki entry for PRIM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRIM2 gene promoter:
         Spz1   Pbx1a   ATF-2   STAT5A   E2F   COMP1   FOXJ2 (long isoform)   IRF-7A   STAT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRIM2 promoter sequence
   Search Chromatin IP Primers for PRIM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRIM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12-p11.1   Ensembl cytogenetic band:  6p11.2   HGNC cytogenetic band: 6p12-p11.1

PRIM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRIM2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P057179:  view genomic region     (about GC identifiers)

Start:
57,179,603 bp from pter      End:
57,513,375 bp from pter
Size:
333,773 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643 (See protein sequence)
Recommended Name: DNA primase large subunit  
Size: 509 amino acids; 58806 Da
Cofactor: Binds 1 4Fe-4S cluster
Subunit: Heterodimer of a small subunit and a large subunit
5 PDB 3D structures from and Proteopedia for PRIM2:
3L9Q (3D)        3Q36 (3D)        4BPU (3D)        4BPW (3D)        4BPX (3D)    
Secondary accessions: Q53FJ8 Q6P1Q7 Q8WVL2 Q9H413
Alternative splicing: 2 isoforms:  P49643-1   P49643-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRIM2: NX_P49643

Explore proteomics data for PRIM2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys54, Lys65, Lys139, Lys395, Lys402, Lys416
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PRIM2 (P49643)
     SHFILRLAYC  GKEGKRTDYTP 


    See PRIM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000938.2  NP_001269416.1  NP_001269417.1  

    ENSEMBL proteins: 
     ENSP00000475738  
    Reactome Protein details: P49643

    PRIM2 Human Recombinant Protein Products:

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    Novus Biologicals PRIM2 Protein
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    Cloud-Clone Corp. Proteins for PRIM2

     
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    LSBio Antibodies in human, mouse, rat for PRIM2

    PRIM2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007238 DNA_primase_lsu_euk/arc
     IPR016558 DNA_primase_lsu_euk

    Graphical View of Domain Structure for InterPro Entry P49643

    ProtoNet protein and cluster: P49643

    1 Blocks protein domain: IPB007238 Eukaryotic-type DNA primase

    UniProtKB/Swiss-Prot: PRI2_HUMAN, P49643
    Similarity: Belongs to the eukaryotic-type primase large subunit family


    Find genes that share domains with PRIM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRI2_HUMAN, P49643
    Function: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during
    discontinuous DNA replication

         Enzyme Numbers (IUBMB): EC 2.7.7.-1 EC 2.7.72

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003896DNA primase activity IEA--
    GO:0046872metal ion binding IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--
         
    Find genes that share ontologies with PRIM2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRIM2:
     Decreased Hepatitis C virus re  Decreased cell number and incr  Decreased number of cells in m  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRIM2
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    miRNA
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    Block miRNA regulation of human, mouse, rat PRIM2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate PRIM2:
    hsa-miR-495 hsa-miR-548p hsa-miR-198 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidPRIM2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PRIM2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PRIM2 (NM_000947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRIM2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:1990077primosome complex IEA--

    Find genes that share ontologies with PRIM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRIM2 About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2Telomere C-strand (Lagging Strand) Synthesis
    Telomere C-strand (Lagging Strand) Synthesis0.79
    Polymerase switching on the C-strand of the telomere0.00
    Extension of Telomeres0.79
    Removal of the Flap Intermediate0.00
    Leading Strand Synthesis0.64
    Lagging Strand Synthesis0.00
    Cell cycle Transition and termination of DNA replication0.43
    Polymerase switching0.00
    3E2F mediated regulation of DNA replication
    G1/S Transition0.81
    E2F mediated regulation of DNA replication0.30
    Mitotic G1-G1/S phases0.81
    Inhibition of replication initiation of damaged DNA by RB1/E2F10.00
    G1 to S cell cycle control0.35
    4DNA strand elongation
    DNA strand elongation0.63
    DNA replication0.63
    5CDK-mediated phosphorylation and removal of Cdc6
    Synthesis of DNA0.92
    DNA Replication Pre-Initiation0.81
    DNA Replication0.92
    S Phase0.78
    M/G1 Transition0.81


    Find genes that share SuperPaths with PRIM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PRIM2
        Cell Cycle / Checkpoint Control

    3 GeneGo (Thomson Reuters) Pathways for PRIM2
        Transcription Ligand-dependent activation of the ESR1/SP pathway
    Cell cycle Transition and termination of DNA replication
    Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for PRIM2
        G1 to S cell cycle control
    DNA Replication

    Selected Reactome Pathways for PRIM2 (see all 9)
        Processive synthesis on the lagging strand
    Leading Strand Synthesis
    Removal of the Flap Intermediate
    Inhibition of replication initiation of damaged DNA by RB1/E2F1
    Telomere C-strand synthesis initiation


    4 Kegg Pathways  (Kegg details for PRIM2):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    DNA replication

        Pathway & Disease-focused RT2 Profiler PCR Array including PRIM2: 
              Neurotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRIM2

    Selected Interacting proteins for PRIM2 (P496432, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPA1P276942, 3MINT-5223474 I2D: score=1 
    YWHAZP631042, 3MINT-3318368 I2D: score=1 
    PRIM1P496423I2D: score=8 
    POLA1P098843I2D: score=7 
    ARHGAP1Q079603I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000722telomere maintenance via recombination TAS--
    GO:0000723telomere maintenance TAS--
    GO:0006269DNA replication, synthesis of RNA primer TAS8026492

    Find genes that share ontologies with PRIM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRIM2 (PRI2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRIM2 gene (3 alternative transcripts): 
    NM_000947.3  NM_001282487.1  NM_001282488.1  

    Unigene Cluster for PRIM2:

    Primase, DNA, polypeptide 2 (58kDa)
    Hs.654580  [show with all ESTs]
    Unigene Representative Sequence: NM_000947
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370687 ENST00000274891(uc003pdv.1) ENST00000389488(uc003pdx.3)
    ENST00000419977(uc003pdw.3) ENST00000490313 ENST00000470638 ENST00000550475
    ENST00000607273
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate PRIM2:
    hsa-miR-495 hsa-miR-548p hsa-miR-198 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidPRIM2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRIM2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRIM2 (NM_000947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRIM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRIM2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PRIM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRIM2
      QuantiTect SYBR Green Assays in human, mouse, rat PRIM2
      QuantiFast Probe-based Assays in human, mouse, rat PRIM2
    Flow Cytometry
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    Additional mRNA sequence: 

    AK223287.1 AK291915.1 BC017833.1 BC064931.1 X74331.1 XR_171580.1 

    10 DOTS entries:

    DT.91804401  DT.91933158  DT.75164719  DT.97842490  DT.91927290  DT.121389919  DT.40115500  DT.413688 
    DT.91762640  DT.40115501 

    Selected AceView cDNA sequences (see all 97):

    BP336097 BP353860 BP345363 AU253481 BX280180 BI523986 BU187783 BM756079 
    BC017833 AA361880 BP355074 BM852865 F12922 BP337475 BP337854 BP337209 
    BP353433 BP368182 AL549894 BP356074 BX504279 BM546142 BI547222 BP352309 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRIM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACTTATT
    PRIM2 Expression
    About this image


    PRIM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    PRIM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRIM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654580
        Pathway & Disease-focused RT2 Profiler PCR Array including PRIM2: 
              Neurotoxicity in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PRIM2
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    QuantiFast Probe-based Assays in human, mouse, rat PRIM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRIM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRIM2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prim21 , 5 DNA primase, p58 subunit1, 5 84.36(n)1
    90.1(a)1
      1 (12.70 cM)5
    190761  NM_008922.21  NP_032948.11 
     334538115 
    chicken
    (Gallus gallus)
    Aves PRIM21 primase, DNA, polypeptide 2 (58kDa) 69.43(n)
    68.84(a)
      421878  NM_001012880.1  NP_001012898.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRIM26
    primase, DNA, polypeptide 2 (58kDa)
    41(a)
    1 ↔ 1
    1(163009850-163102028)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.74592 Xenopus laevis transcribed sequence with weak similarity more 76.41(n)    CA982049.1 
    zebrafish
    (Danio rerio)
    Actinopterygii anxa1c2 Danio rerio clone RK137A2F09 primase, polypeptide 2A, more 72.06(n)    AY398398.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DNApol-alpha601 DNA polymerase alpha 60kD 47(n)
    39.91(a)
      44915  NM_143744.4  NP_652001.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pri-21 pri-2 49.15(n)
    42.76(a)
      173122  NM_001264993.1  NP_001251922.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRI21 PRI2 47.05(n)
    38.18(a)
      853821   NP_012879.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G673201 AT1G67320 50.82(n)
    44.76(a)
      843052  NM_001198410.1  NP_001185339.1 
    rice
    (Oryza sativa)
    Liliopsida Os.113832 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.12(n)    AK064087.1 


    ENSEMBL Gene Tree for PRIM2 (if available)
    TreeFam Gene Tree for PRIM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    8 SNPs for PRIM2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    rs50114031,2,4
    ----see VAR_0597422 mis40--------
    rs42940071,2,4
    ----see VAR_0597472 mis40--------
    rs94760801,2,4
    ----see VAR_0597452 mis40--------
    rs42940081,2,4
    ----see VAR_0597482 mis40--------
    rs37631831,2,4
    ----see VAR_0515062 mis40--------
    rs9271921,2,4
    ----see VAR_0597442 mis40--------
    rs43071641,2,4
    ----see VAR_0597462 mis40--------
    rs69135461,2,4
    ----see VAR_0597432 mis40--------

    HapMap Linkage Disequilibrium report for PRIM2 (57179603 - 57429603 bp, first 250kb of PRIM2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRIM2 (see all 103):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1949021CNV Deletion18987734
    esv988239CNV Deletion20482838
    esv1008673CNV Deletion20482838
    esv1930914CNV Deletion18987734
    esv2732138CNV Deletion23290073
    dgv1054e201CNV Deletion23290073
    esv1005755CNV Deletion20482838
    esv2732135CNV Deletion23290073
    esv2732152CNV Deletion23290073
    esv2732142CNV Deletion23290073

    Human Gene Mutation Database (HGMD): PRIM2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PRIM2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRIM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176636    OMIM disorders: --


    Find genes that share disorders with PRIM2           About GenesLikeMe

    Genetic Association Database (GAD): PRIM2
    Human Genome Epidemiology (HuGE) Navigator: PRIM2 (1 document)

    Export disorders for PRIM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRIM2 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with PRIM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. (PubMed id 8530050)1, 3, 9 Shiratori A....Miyazawa H. (Genomics 1995)
    2. An iron-sulfur cluster in the C-terminal domain of the p58 subunit of human DNA primase. (PubMed id 17893144)1, 2, 9 Weiner B.E....Chazin W.J. (J. Biol. Chem. 2007)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The genomic distribution and local context of coincident SNPs in human and chimpanzee. (PubMed id 20675616)1, 3 Hodgkinson A. and Eyre-Walker A. (Genome Biol Evol 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. DNA replication in vitro by recombinant DNA-polymerase-alpha- primase. (PubMed id 8026492)1, 2 Stadlbauer F.... Nasheuer H.-P. (Eur. J. Biochem. 1994)
    8. Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180. (PubMed id 12220650)1, 9 Smith R.W. and Nasheuer H.P. (FEBS Lett. 2002)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. (PubMed id 22437878)1 Chung J....Piedrahita J.A. (Epigenetics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5558 HGNC: 9370 AceView: PRIM2A Ensembl:ENSG00000146143 euGenes: HUgn5558
    ECgene: PRIM2 Kegg: 5558 H-InvDB: PRIM2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRIM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRIM2 gene:
    Search GeneIP for patents involving PRIM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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