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Aliases for PRICKLE4 Gene

Aliases for PRICKLE4 Gene

  • Prickle Homolog 4 (Drosophila) 2 3
  • C6orf49 3 4 6
  • Overexpressed Breast Tumor Protein 3 4
  • OBTP 3 6
  • OEBT 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3
  • Over-Expressed Breast Tumor Protein 3
  • Chromosome 6 Open Reading Frame 49 2
  • Prickle-Like Protein 4 3
  • TOMM6 3

External Ids for PRICKLE4 Gene

Previous Symbols for PRICKLE4 Gene

  • C6orf49

Summaries for PRICKLE4 Gene

Entrez Gene Summary for PRICKLE4 Gene

  • C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRICKLE4 Gene

PRICKLE4 (Prickle Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import.

Gene Wiki entry for PRICKLE4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE4 Gene

Genomics for PRICKLE4 Gene

Genomic Location for PRICKLE4 Gene

Start:
41,780,762 bp from pter
End:
41,787,372 bp from pter
Size:
6,611 bases
Orientation:
Plus strand

Genomic View for PRICKLE4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRICKLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE4 Gene

Regulatory Elements for PRICKLE4 Gene

Proteins for PRICKLE4 Gene

  • Protein details for PRICKLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TBC4-PRIC4_HUMAN
    Recommended name:
    Prickle-like protein 4
    Protein Accession:
    Q2TBC4
    Secondary Accessions:
    • A2A3M0
    • A6PVU1
    • B3KQ15
    • Q5T3D4
    • Q9NSV1

    Protein attributes for PRICKLE4 Gene

    Size:
    344 amino acids
    Molecular mass:
    37551 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE4 Gene

Proteomics data for PRICKLE4 Gene at MOPED

Post-translational modifications for PRICKLE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRICKLE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRICKLE4 Gene

Domains for PRICKLE4 Gene

Protein Domains for PRICKLE4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PRIC4_HUMAN
Domain:
  • Contains 2 LIM zinc-binding domains.:
    • Q2TBC4
  • Contains 1 PET domain.:
    • Q2TBC4
Family:
  • Belongs to the prickle / espinas / testin family.:
    • Q2TBC4
genes like me logo Genes that share domains with PRICKLE4: view

No data available for Gene Families for PRICKLE4 Gene

Function for PRICKLE4 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE4: view

miRNA for PRICKLE4 Gene

miRTarBase miRNAs that target PRICKLE4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRICKLE4 Gene

Localization for PRICKLE4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRICKLE4 Gene COMPARTMENTS Subcellular localization image for PRICKLE4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15702247
genes like me logo Genes that share ontologies with PRICKLE4: view

Pathways for PRICKLE4 Gene

genes like me logo Genes that share pathways with PRICKLE4: view

Pathways by source for PRICKLE4 Gene

2 Reactome pathways for PRICKLE4 Gene

Interacting Proteins for PRICKLE4 Gene

Gene Ontology (GO) - Biological Process for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE4: view

Transcripts for PRICKLE4 Gene

mRNA/cDNA for PRICKLE4 Gene

Unigene Clusters for PRICKLE4 Gene

Prickle homolog 4 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c · 12d
SP1: - - - - - -
SP2:
SP3: - -
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10: - -

Relevant External Links for PRICKLE4 Gene

GeneLoc Exon Structure for
PRICKLE4
ECgene alternative splicing isoforms for
PRICKLE4

Expression for PRICKLE4 Gene

mRNA expression in normal human tissues for PRICKLE4 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRICKLE4 Gene

SOURCE GeneReport for Unigene cluster for PRICKLE4 Gene Hs.715653

mRNA Expression by UniProt/SwissProt for PRICKLE4 Gene

Q2TBC4-PRIC4_HUMAN
Tissue specificity: Expressed in a broad range of normal tissues as well as in hepatocellular carcinoma, breast cancer and prostate cancer tissues.
genes like me logo Genes that share expressions with PRICKLE4: view

Orthologs for PRICKLE4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRICKLE4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRICKLE4 36
  • 81.43 (n)
  • 71.62 (a)
mouse
(Mus musculus)
Mammalia Prickle4 36
  • 76.18 (n)
  • 67.93 (a)
Prickle4 16
rat
(Rattus norvegicus)
Mammalia Prickle4 36
  • 76.16 (n)
  • 68.99 (a)
Species with no ortholog for PRICKLE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRICKLE4 Gene

ENSEMBL:
Gene Tree for PRICKLE4 (if available)
TreeFam:
Gene Tree for PRICKLE4 (if available)

Paralogs for PRICKLE4 Gene

Selected SIMAP similar genes for PRICKLE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRICKLE4: view

No data available for Paralogs for PRICKLE4 Gene

Variants for PRICKLE4 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1342549 -- 41,783,975(+) CCTTG(C/T)ACTCA intron-variant
rs4523083 -- 41,783,683(+) ACCCG(A/G)AGGTA intron-variant
rs6905726 -- 41,783,074(+) GTGCA(C/T)GGTGA intron-variant
rs6925323 -- 41,782,652(+) ctccc(A/G)gagtg intron-variant
rs6925777 -- 41,783,084(+) AGAAA(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE4 Gene

Variant ID Type Subtype PubMed ID
nsv885833 CNV Loss 21882294
esv2678409 CNV Deletion 23128226

Relevant External Links for PRICKLE4 Gene

HapMap Linkage Disequilibrium report
PRICKLE4

Disorders for PRICKLE4 Gene

Relevant External Links for PRICKLE4

Genetic Association Database (GAD)
PRICKLE4
Human Genome Epidemiology (HuGE) Navigator
PRICKLE4
genes like me logo Genes that share disorders with PRICKLE4: view

No data available for UniProtKB/Swiss-Prot for PRICKLE4 Gene

Publications for PRICKLE4 Gene

  1. Characterization of OEBT, a LIM protein. (PMID: 15702247) Teufel A. … Lohse A.W. (Int. J. Mol. Med. 2005) 2 3 4 23
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PRICKLE4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PRICKLE4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE4
    • Block miRNA regulation of PRICKLE4 using miScript Target Protectors

    Sources for PRICKLE4 Gene

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