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Aliases for PRICKLE4 Gene

Aliases for PRICKLE4 Gene

  • Prickle Homolog 4 2 3
  • Overexpressed Breast Tumour Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • C6orf49 3 4
  • OEBT 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3
  • Over-Expressed Breast Tumor Protein 3
  • Chromosome 6 Open Reading Frame 49 2
  • Prickle Homolog 4 (Drosophila) 2
  • TOMM6 3
  • OBTP 3

External Ids for PRICKLE4 Gene

Previous HGNC Symbols for PRICKLE4 Gene

  • C6orf49

Previous GeneCards Identifiers for PRICKLE4 Gene

  • GC06P041857
  • GC06P041467

Summaries for PRICKLE4 Gene

Entrez Gene Summary for PRICKLE4 Gene

  • C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRICKLE4 Gene

PRICKLE4 (Prickle Homolog 4) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Mitochondrial protein import. An important paralog of this gene is PRICKLE3.

Gene Wiki entry for PRICKLE4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE4 Gene

Genomics for PRICKLE4 Gene

Regulatory Elements for PRICKLE4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRICKLE4 Gene

Chromosome:
6
Start:
41,780,349 bp from pter
End:
41,790,141 bp from pter
Size:
9,793 bases
Orientation:
Plus strand

Genomic View for PRICKLE4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRICKLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE4 Gene

Proteins for PRICKLE4 Gene

  • Protein details for PRICKLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TBC4-PRIC4_HUMAN
    Recommended name:
    Prickle-like protein 4
    Protein Accession:
    Q2TBC4
    Secondary Accessions:
    • A2A3M0
    • A6PVU1
    • B3KQ15
    • Q5T3D4
    • Q9NSV1

    Protein attributes for PRICKLE4 Gene

    Size:
    344 amino acids
    Molecular mass:
    37551 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE4 Gene

Proteomics data for PRICKLE4 Gene at MOPED

Post-translational modifications for PRICKLE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRICKLE4 Gene

No data available for DME Specific Peptides for PRICKLE4 Gene

Domains & Families for PRICKLE4 Gene

Gene Families for PRICKLE4 Gene

Protein Domains for PRICKLE4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRICKLE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TBC4

UniProtKB/Swiss-Prot:

PRIC4_HUMAN :
  • Contains 2 LIM zinc-binding domains.
  • Belongs to the prickle / espinas / testin family.
Domain:
  • Contains 2 LIM zinc-binding domains.
  • Contains 1 PET domain.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE4: view

Function for PRICKLE4 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE4: view

Phenotypes for PRICKLE4 Gene

GenomeRNAi human phenotypes for PRICKLE4:
genes like me logo Genes that share phenotypes with PRICKLE4: view

Animal Model Products

CRISPR Products

miRNA for PRICKLE4 Gene

miRTarBase miRNAs that target PRICKLE4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PRICKLE4 Gene

Localization for PRICKLE4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRICKLE4 Gene COMPARTMENTS Subcellular localization image for PRICKLE4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15702247
genes like me logo Genes that share ontologies with PRICKLE4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE4 Gene

Pathways & Interactions for PRICKLE4 Gene

genes like me logo Genes that share pathways with PRICKLE4: view

Pathways by source for PRICKLE4 Gene

Interacting Proteins for PRICKLE4 Gene

Gene Ontology (GO) - Biological Process for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE4: view

No data available for SIGNOR curated interactions for PRICKLE4 Gene

Drugs & Compounds for PRICKLE4 Gene

No Compound Related Data Available

Transcripts for PRICKLE4 Gene

mRNA/cDNA for PRICKLE4 Gene

Unigene Clusters for PRICKLE4 Gene

Prickle homolog 4 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE4 Gene

No ASD Table

Relevant External Links for PRICKLE4 Gene

GeneLoc Exon Structure for
PRICKLE4
ECgene alternative splicing isoforms for
PRICKLE4

Expression for PRICKLE4 Gene

mRNA expression in normal human tissues for PRICKLE4 Gene

Protein differential expression in normal tissues from HIPED for PRICKLE4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRICKLE4 Gene



SOURCE GeneReport for Unigene cluster for PRICKLE4 Gene Hs.715653

mRNA Expression by UniProt/SwissProt for PRICKLE4 Gene

Q2TBC4-PRIC4_HUMAN
Tissue specificity: Expressed in a broad range of normal tissues as well as in hepatocellular carcinoma, breast cancer and prostate cancer tissues.
genes like me logo Genes that share expression patterns with PRICKLE4: view

Protein tissue co-expression partners for PRICKLE4 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRICKLE4 Gene

Orthologs for PRICKLE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRICKLE4 35
  • 81.43 (n)
  • 71.62 (a)
PRICKLE4 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prickle4 35
  • 76.18 (n)
  • 67.93 (a)
Prickle4 16
Gm21981 36
  • 68 (a)
OneToMany
Prickle4 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prickle4 35
  • 76.16 (n)
  • 68.99 (a)
cow
(Bos Taurus)
Mammalia PRICKLE4 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRICKLE4 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRICKLE4 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRICKLE4 36
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRICKLE4 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prkl-1 36
  • 23 (a)
OneToMany
Species with no ortholog for PRICKLE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PRICKLE4 Gene

ENSEMBL:
Gene Tree for PRICKLE4 (if available)
TreeFam:
Gene Tree for PRICKLE4 (if available)

Paralogs for PRICKLE4 Gene

Paralogs for PRICKLE4 Gene

(6) SIMAP similar genes for PRICKLE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRICKLE4: view

Variants for PRICKLE4 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1342549 -- 41,783,975(+) CCTTG(C/T)ACTCA intron-variant
rs4523083 -- 41,783,683(+) ACCCG(A/G)AGGTA intron-variant
rs6905726 -- 41,783,074(+) GTGCA(C/T)GGTGA intron-variant
rs6925323 -- 41,782,652(+) ctccc(A/G)gagtg intron-variant
rs6925777 -- 41,783,084(+) AGAAA(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE4 Gene

Variant ID Type Subtype PubMed ID
nsv885833 CNV Loss 21882294
esv2678409 CNV Deletion 23128226

Variation tolerance for PRICKLE4 Gene

Residual Variation Intolerance Score: 80.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRICKLE4 Gene

HapMap Linkage Disequilibrium report
PRICKLE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE4 Gene

Disorders for PRICKLE4 Gene

Relevant External Links for PRICKLE4

Genetic Association Database (GAD)
PRICKLE4
Human Genome Epidemiology (HuGE) Navigator
PRICKLE4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRICKLE4
genes like me logo Genes that share disorders with PRICKLE4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRICKLE4 Gene

Publications for PRICKLE4 Gene

  1. Characterization of OEBT, a LIM protein. (PMID: 15702247) Teufel A. … Lohse A.W. (Int. J. Mol. Med. 2005) 2 23 67
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 67

Products for PRICKLE4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate PRICKLE4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE4
    • Block miRNA regulation of PRICKLE4 using miScript Target Protectors

    Sources for PRICKLE4 Gene

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