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PRICKLE4 Gene

protein-coding   GIFtS: 49
GCID: GC06P041748

Prickle Homolog 4 (Drosophila)

(Previous name: chromosome 6 open reading frame 49)
(Previous symbol: C6orf49)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prickle Homolog 4 (Drosophila)1 2     Chromosome 6 Open Reading Frame 491
C6orf491 2 3 5     TOMM62
Overexpressed Breast Tumor Protein2 3     Over-Expressed Breast Tumor Protein2
OEBT2 3     Prickle-Like Protein 42
OBTP2 5     Translocase Of Outer Mitochondrial Membrane 6 Homolog2

External Ids:    HGNC: 168051   Entrez Gene: 299642   Ensembl: ENSG000001245937   OMIM: 6113895   UniProtKB: Q2TBC43   

Export aliases for PRICKLE4 gene to outside databases

Previous GC identifers: GC06P041857 GC06P041467


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRICKLE4 Gene:
C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 (PubMed 15702247)).(supplied by OMIM,
Mar 2008)

GeneCards Summary for PRICKLE4 Gene:
PRICKLE4 (prickle homolog 4 (Drosophila)) is a protein-coding gene. Diseases associated with PRICKLE4 include hepatocellular carcinoma, and prostate cancer. An important paralog of this gene is PRICKLE3.

Gene Wiki entry for PRICKLE4 (C6orf49) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PRICKLE4 gene promoter:
         E2F-4   E2F-3a   C/EBPbeta   E2F-5   p53   Lmo2   E2F-2   MZF-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRICKLE4 promoter sequence
   Search Chromatin IP Primers for PRICKLE4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRICKLE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

PRICKLE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRICKLE4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P041748:  view genomic region     (about GC identifiers)

Start:
41,748,087 bp from pter      End:
41,757,879 bp from pter
Size:
9,793 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRIC4_HUMAN, Q2TBC4 (See protein sequence)
Recommended Name: Prickle-like protein 4  
Size: 344 amino acids; 37551 Da
Secondary accessions: A2A3M0 A6PVU1 B3KQ15 Q5T3D4 Q9NSV1
Alternative splicing: 3 isoforms:  Q2TBC4-1   Q2TBC4-2   Q2TBC4-3   

Explore the universe of human proteins at neXtProt for PRICKLE4: NX_Q2TBC4

Explore proteomics data for PRICKLE4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRICKLE4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037529.3  
    ENSEMBL proteins: 
     ENSP00000389023   ENSP00000335185   ENSP00000377806   ENSP00000377802   ENSP00000377803  
     ENSP00000404911   ENSP00000352128  

    PRICKLE4 Human Recombinant Protein Products:

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    OriGene Purified Protein for PRICKLE4
    OriGene Protein Over-expression Lysate for PRICKLE4
    OriGene Custom MassSpec
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for PRICKLE4

    PRICKLE4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals PRICKLE4 Antibody
    Abcam antibodies for PRICKLE4
    Cloud-Clone Corp. Antibodies for PRICKLE4
    ThermoFisher Antibodies for PRICKLE4
    LSBio Antibodies in human, mouse, rat for PRICKLE4

    PRICKLE4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRICKLE4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRICKLE4
    Cloud-Clone Corp. CLIAs for PRICKLE4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010442 PET_domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q2TBC4

    ProtoNet protein and cluster: Q2TBC4

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: PRIC4_HUMAN, Q2TBC4
    Similarity: Belongs to the prickle / espinas / testin family
    Similarity: Contains 2 LIM zinc-binding domains
    Similarity: Contains 1 PET domain


    PRICKLE4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--
         
    PRICKLE4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRICKLE4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRICKLE4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRICKLE4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRICKLE4

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRICKLE4:
    hsa-mir-222-3p (MIRT046728), hsa-mir-193b-3p (MIRT041605), hsa-mir-615-3p (MIRT040154)

    Block miRNA regulation of human, mouse, rat PRICKLE4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRICKLE4
    SwitchGear 3'UTR luciferase reporter plasmidPRICKLE4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRICKLE4
    Predesigned siRNA for gene silencing in human, mouse, rat PRICKLE4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRICKLE4

    Clone
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    OriGene clones in human, mouse for PRICKLE4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRICKLE4 (NM_013397)
    Sino Biological Human cDNA Clone for PRICKLE4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRICKLE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRICKLE4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PRICKLE4
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRICKLE4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRICKLE4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS15702247

    PRICKLE4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRICKLE4
    Interactions:

        Search GeneGlobe Interaction Network for PRICKLE4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for PRICKLE4 (ENSP000003351854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP27ENSP000003661214STRING: ENSP00000366121
    RHOAENSP000004001754STRING: ENSP00000400175
    --ENSP000004085804STRING: ENSP00000408580
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    PRICKLE4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRICKLE4 (PRIC4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRICKLE4 gene: 
    NM_013397.5  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456057(uc011duf.1 uc003ord.2 uc003org.3 uc011dug.1)
    ENST00000487182 ENST00000335515 ENST00000394263 ENST00000394259 ENST00000394260
    ENST00000463606 ENST00000483200 ENST00000458694 ENST00000359201
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRICKLE4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRICKLE4
    SwitchGear 3'UTR luciferase reporter plasmidPRICKLE4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRICKLE4
    Predesigned siRNA for gene silencing in human, mouse, rat PRICKLE4
    Clone
    Products:
         
    OriGene clones in human, mouse for PRICKLE4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRICKLE4 (NM_013397)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRICKLE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRICKLE4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRICKLE4
    OriGene qSTAR qPCR primer pairs in human, mouse for PRICKLE4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PRICKLE4
      QuantiTect SYBR Green Assays in human, mouse, rat PRICKLE4
      QuantiFast Probe-based Assays in human, mouse, rat PRICKLE4

    Selected AceView cDNA sequences (see all 480):

    BU681511 W56319 BM783950 BG034615 AA513298 AI362860 AI128408 BM756647 
    BG165210 AI051691 BM784474 BM553274 AI709197 BC027896 AA863102 AA380414 
    AW591893 N20416 AA526888 CB116531 CB105365 BM904024 AA854540 BQ229135 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE4 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                -     -     -     -                 -                                                                 -                     
    SP2:                                                                                                                                                            
    SP3:        -     -                                                                                                                                             
    SP4:              -                                                                                                                                             
    SP5:                                                                    -                                                                                       


    ECgene alternative splicing isoforms for PRICKLE4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRICKLE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTAGTGGC
    PRICKLE4 Expression
    About this image

    PRICKLE4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRICKLE4 Protein Expression

    UniProtKB/Swiss-Prot: PRIC4_HUMAN, Q2TBC4
    Tissue specificity: Expressed in a broad range of normal tissues as well as in hepatocellular carcinoma, breast
    cancer and prostate cancer tissues

        Custom PCR Arrays for PRICKLE4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PRICKLE4
    QuantiTect SYBR Green Assays in human, mouse, rat PRICKLE4
    QuantiFast Probe-based Assays in human, mouse, rat PRICKLE4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRICKLE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRICKLE4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prickle41 , 5 prickle homolog 4 (Drosophila)1, 5 76.18(n)1
    67.93(a)1
      17 (23.87 cM)5
    3811041  XM_006525238.11  XP_006525301.11 
     476885175 
    chicken
    (Gallus gallus)
    Aves PRICKLE46
    prickle homolog 4 (Drosophila)
    31(a)
    1 ↔ 1
    26(5001119-5006673)
    lizard
    (Anolis carolinensis)
    Reptilia PRICKLE46
    prickle homolog 4 (Drosophila)
    39(a)
    1 ↔ 1
    4(119420592-119430503)
    worm
    (Caenorhabditis elegans)
    Secernentea prkl-16
    Protein PRKL-1, isoform a (prkl-1) mRNA, complete ...
    23(a)
    1 → many
    IV(6978775-6986935) WBGene00022727


    ENSEMBL Gene Tree for PRICKLE4 (if available)
    TreeFam Gene Tree for PRICKLE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRICKLE4 gene
    PRICKLE32  LMCD12  TES2  PRICKLE22  PRICKLE12  
    6 SIMAP similar genes for PRICKLE4 using alignment to 3 protein entries:     PRIC4_HUMAN (see all proteins):
    DKFZp586B2022    TES    PRICKLE1    RILP    PRICKLE3    PRICKLE2

    PRICKLE4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRICKLE4 (see all 112)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125236721,2
    C,F,A,H--41749692(+) GGTTTG/TTGTAT 1 -- int121Minor allele frequency- T:0.41NS EA WA NA CSA 2347
    rs1477568371,2
    --41749773(+) GAGGGC/TGGGGC 1 -- int10--------
    rs132051771,2
    C,F--41749829(+) gagacG/Agagtc 1 -- int12Minor allele frequency- A:0.50NA 4
    rs131939741,2
    C,F,A,H--41749896(+) TGCCTC/TCCAGG 1 -- int114Minor allele frequency- T:0.21NS EA NA WA CSA 767
    rs1468419791,2
    --41749953(+) TACAGA/GCACAC 1 -- int10--------
    rs360261241,2
    C,F--41749976(+) AGCTTG/ATTTTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1923838371,2
    --41750030(+) GTCTCA/GAACCA 1 -- int10--------
    rs2011453391,2
    --41750118(+) GGTCA-/CTTCTTCT 1 -- int10--------
    rs2003379021,2
    --41750123(+) CTTCT-/TCTTTTT 1 -- int10--------
    rs671443951,2
    C--41750124(+) TTCTT-/C/CT  
            
    TTTTT
    1 -- int11NA 2

    HapMap Linkage Disequilibrium report for PRICKLE4 (41748087 - 41757879 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRICKLE4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678409CNV Deletion23128226
    nsv885833CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRICKLE4
    DNA2.0 Custom Variant and Variant Library Synthesis for PRICKLE4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611389    OMIM disorders: --

    4 diseases for PRICKLE4:    
    About MalaCards
    hepatocellular carcinoma    prostate cancer    prostatitis    breast cancer


    PRICKLE4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRICKLE4
    Human Genome Epidemiology (HuGE) Navigator: PRICKLE4 (1 document)

    Export disorders for PRICKLE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRICKLE4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PRICKLE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of OEBT, a LIM protein. (PubMed id 15702247)1, 2, 3, 9 Teufel A.... Lohse A.W. (Int. J. Mol. Med. 2005)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts. (PubMed id 7923143)1 Chassin D....Tournaire M. (Cancer Res. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29964 HGNC: 16805 AceView: C6orf49 Ensembl:ENSG00000124593 euGenes: HUgn29964
    ECgene: PRICKLE4 H-InvDB: PRICKLE4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRICKLE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRICKLE4 gene:
    Search GeneIP for patents involving PRICKLE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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