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Aliases for PRICKLE4 Gene

Aliases for PRICKLE4 Gene

  • Prickle Planar Cell Polarity Protein 4 2 3 5
  • Overexpressed Breast Tumour Protein 2 3
  • Overexpressed Breast Tumor Protein 3 4
  • C6orf49 3 4
  • OEBT 3 4
  • Translocase Of Outer Mitochondrial Membrane 6 Homolog 3
  • Over-Expressed Breast Tumor Protein 3
  • Chromosome 6 Open Reading Frame 49 2
  • Prickle Homolog 4 (Drosophila) 2
  • Prickle-Like Protein 4 3
  • Prickle Homolog 4 3
  • TOMM6 3
  • OBTP 3

External Ids for PRICKLE4 Gene

Previous HGNC Symbols for PRICKLE4 Gene

  • C6orf49

Previous GeneCards Identifiers for PRICKLE4 Gene

  • GC06P041857
  • GC06P041467

Summaries for PRICKLE4 Gene

Entrez Gene Summary for PRICKLE4 Gene

  • C6ORF49 is a member of the LIM domain protein family (Teufel et al., 2005 [PubMed 15702247]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PRICKLE4 Gene

PRICKLE4 (Prickle Planar Cell Polarity Protein 4) is a Protein Coding gene. An important paralog of this gene is PRICKLE3.

Gene Wiki entry for PRICKLE4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE4 Gene

Genomics for PRICKLE4 Gene

Regulatory Elements for PRICKLE4 Gene

Enhancers for PRICKLE4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F041934 1.3 FANTOM5 ENCODE 69.8 +157.9 157944 8.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 PRICKLE4 USP49 FRS3 MED20 UBR2 ENSG00000207371 BYSL RNU6-761P TOMM6 ENSG00000206977
GH06F041779 0.2 ENCODE 65.9 -0.2 -173 2.9 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 PRICKLE4 GLTSCR1L TREML2 UBR2 USP49 MED20 PIR31477
GH06F041784 0.7 ENCODE 64.9 +5.5 5457 4.2 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A ZNF2 YY1 SLC30A9 PRICKLE4 MED20 FRS3 USP49 BYSL ENSG00000207371 PGC
GH06F041878 0.2 ENCODE 62.8 +98.4 98401 1.3 ATF1 PKNOX1 ARNT SIN3A ARID4B DMAP1 SLC30A9 GATA2 FOS DEK PRICKLE4 MED20 BYSL ENSG00000207371 ENSG00000206977 RNU6-761P ENSG00000227516 USP49
GH06F041824 0.8 Ensembl ENCODE 62.7 +44.4 44440 0.8 SMARCE1 JUND POLR2A JUN IKZF1 FOS FOSL2 PRICKLE4 GC06P041832 PIR43865
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PRICKLE4 on UCSC Golden Path with GeneCards custom track

Promoters for PRICKLE4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216643 -462 2201 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143

Genomic Location for PRICKLE4 Gene

Chromosome:
6
Start:
41,780,762 bp from pter
End:
41,787,372 bp from pter
Size:
6,611 bases
Orientation:
Plus strand

Genomic View for PRICKLE4 Gene

Genes around PRICKLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRICKLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRICKLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE4 Gene

Proteins for PRICKLE4 Gene

  • Protein details for PRICKLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TBC4-PRIC4_HUMAN
    Recommended name:
    Prickle-like protein 4
    Protein Accession:
    Q2TBC4
    Secondary Accessions:
    • A2A3M0
    • A6PVU1
    • B3KQ15
    • Q5T3D4
    • Q9NSV1

    Protein attributes for PRICKLE4 Gene

    Size:
    344 amino acids
    Molecular mass:
    37551 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE4 Gene

Post-translational modifications for PRICKLE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRICKLE4 Gene

No data available for DME Specific Peptides for PRICKLE4 Gene

Domains & Families for PRICKLE4 Gene

Protein Domains for PRICKLE4 Gene

Suggested Antigen Peptide Sequences for PRICKLE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TBC4

UniProtKB/Swiss-Prot:

PRIC4_HUMAN :
  • Contains 2 LIM zinc-binding domains.
  • Belongs to the prickle / espinas / testin family.
Domain:
  • Contains 2 LIM zinc-binding domains.
  • Contains 1 PET domain.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE4: view

Function for PRICKLE4 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE4: view
genes like me logo Genes that share phenotypes with PRICKLE4: view

Animal Model Products

miRNA for PRICKLE4 Gene

miRTarBase miRNAs that target PRICKLE4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRICKLE4 Gene

Localization for PRICKLE4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRICKLE4 Gene COMPARTMENTS Subcellular localization image for PRICKLE4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 15702247
genes like me logo Genes that share ontologies with PRICKLE4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE4 Gene

Pathways & Interactions for PRICKLE4 Gene

SuperPathways for PRICKLE4 Gene

No Data Available

Interacting Proteins for PRICKLE4 Gene

Selected Interacting proteins: Q2TBC4-PRIC4_HUMAN for PRICKLE4 Gene via IID

Gene Ontology (GO) - Biological Process for PRICKLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE4: view

No data available for Pathways by source and SIGNOR curated interactions for PRICKLE4 Gene

Transcripts for PRICKLE4 Gene

mRNA/cDNA for PRICKLE4 Gene

Unigene Clusters for PRICKLE4 Gene

Prickle homolog 4 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE4 Gene

No ASD Table

Relevant External Links for PRICKLE4 Gene

GeneLoc Exon Structure for
PRICKLE4
ECgene alternative splicing isoforms for
PRICKLE4

Expression for PRICKLE4 Gene

mRNA expression in normal human tissues for PRICKLE4 Gene

Protein differential expression in normal tissues from HIPED for PRICKLE4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRICKLE4 Gene



Protein tissue co-expression partners for PRICKLE4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRICKLE4 Gene:

PRICKLE4

SOURCE GeneReport for Unigene cluster for PRICKLE4 Gene:

Hs.715653

mRNA Expression by UniProt/SwissProt for PRICKLE4 Gene:

Q2TBC4-PRIC4_HUMAN
Tissue specificity: Expressed in a broad range of normal tissues as well as in hepatocellular carcinoma, breast cancer and prostate cancer tissues.
genes like me logo Genes that share expression patterns with PRICKLE4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRICKLE4 Gene

Orthologs for PRICKLE4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRICKLE4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PRICKLE4 34
  • 81.43 (n)
mouse
(Mus musculus)
Mammalia Prickle4 34 16
  • 76.18 (n)
rat
(Rattus norvegicus)
Mammalia Prickle4 34
  • 76.16 (n)
Species where no ortholog for PRICKLE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRICKLE4 Gene

ENSEMBL:
Gene Tree for PRICKLE4 (if available)
TreeFam:
Gene Tree for PRICKLE4 (if available)

Paralogs for PRICKLE4 Gene

Paralogs for PRICKLE4 Gene

(6) SIMAP similar genes for PRICKLE4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRICKLE4: view

Variants for PRICKLE4 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10947986 -- 41,780,541(+) AGGCC(A/G)TGGAG upstream-variant-2KB
rs10947987 -- 41,786,632(+) ACTCT(C/T)GGCGG intron-variant, upstream-variant-2KB
rs112092184 -- 41,783,744(+) CCTGT(C/G/T)TCTGC intron-variant
rs112183399 -- 41,779,938(+) GGTCA(C/T)CGGCA upstream-variant-2KB
rs112519549 -- 41,785,327(+) CCTCC(C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE4 Gene

Variant ID Type Subtype PubMed ID
esv2678409 CNV deletion 23128226

Variation tolerance for PRICKLE4 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRICKLE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRICKLE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE4 Gene

Disorders for PRICKLE4 Gene

Relevant External Links for PRICKLE4

Genetic Association Database (GAD)
PRICKLE4
Human Genome Epidemiology (HuGE) Navigator
PRICKLE4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRICKLE4

No disorders were found for PRICKLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRICKLE4 Gene

Publications for PRICKLE4 Gene

  1. Characterization of OEBT, a LIM protein. (PMID: 15702247) Teufel A. … Lohse A.W. (Int. J. Mol. Med. 2005) 2 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for PRICKLE4 Gene

Sources for PRICKLE4 Gene

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