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Aliases for PRICKLE3 Gene

Aliases for PRICKLE3 Gene

  • Prickle Homolog 3 (Drosophila) 2 3
  • LMO6 3 4 6
  • Triple LIM Domain Protein 6 3 4
  • LIM Domain Only Protein 6 3 4
  • LMO-6 3 4
  • Prickle-Like Protein 3 3
  • LIM Domain Only 6 2

External Ids for PRICKLE3 Gene

Previous HGNC Symbols for PRICKLE3 Gene

  • LMO6

Previous GeneCards Identifiers for PRICKLE3 Gene

  • GC0XM048919
  • GC0XM049031
  • GC0XM046689

Summaries for PRICKLE3 Gene

Entrez Gene Summary for PRICKLE3 Gene

  • LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRICKLE3 Gene

PRICKLE3 (Prickle Homolog 3 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PRICKLE1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE3 Gene

Genomics for PRICKLE3 Gene

Regulatory Elements for PRICKLE3 Gene

Genomic Location for PRICKLE3 Gene

49,175,197 bp from pter
49,186,528 bp from pter
11,332 bases
Minus strand

Genomic View for PRICKLE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRICKLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE3 Gene

Proteins for PRICKLE3 Gene

  • Protein details for PRICKLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prickle-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B7Z8F2
    • O76007
    • Q53XR5

    Protein attributes for PRICKLE3 Gene

    615 amino acids
    Molecular mass:
    68609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE3 Gene


neXtProt entry for PRICKLE3 Gene

Proteomics data for PRICKLE3 Gene at MOPED

Post-translational modifications for PRICKLE3 Gene

  • Ubiquitination at Lys126
  • Modification sites at PhosphoSitePlus

Other Protein References for PRICKLE3 Gene

Antibody Products

No data available for DME Specific Peptides for PRICKLE3 Gene

Domains for PRICKLE3 Gene

Protein Domains for PRICKLE3 Gene


Suggested Antigen Peptide Sequences for PRICKLE3 Gene

Graphical View of Domain Structure for InterPro Entry



  • O43900
  • Contains 3 LIM zinc-binding domains.
  • Contains 1 PET domain.
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE3: view

No data available for Gene Families for PRICKLE3 Gene

Function for PRICKLE3 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE3: view

Phenotypes for PRICKLE3 Gene

genes like me logo Genes that share phenotypes with PRICKLE3: view

Animal Model Products

CRISPR Products

miRNA for PRICKLE3 Gene

miRTarBase miRNAs that target PRICKLE3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRICKLE3 Gene

Localization for PRICKLE3 Gene

Subcellular locations from

Jensen Localization Image for PRICKLE3 Gene COMPARTMENTS Subcellular localization image for PRICKLE3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PRICKLE3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Pathways for PRICKLE3 Gene

SuperPathways for PRICKLE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE3: view

No data available for Pathways by source for PRICKLE3 Gene

Transcripts for PRICKLE3 Gene

Unigene Clusters for PRICKLE3 Gene

Prickle homolog 3 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP6: -

Relevant External Links for PRICKLE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRICKLE3 Gene

mRNA expression in normal human tissues for PRICKLE3 Gene

Protein differential expression in normal tissues for PRICKLE3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRICKLE3 Gene

SOURCE GeneReport for Unigene cluster for PRICKLE3 Gene Hs.732712

mRNA Expression by UniProt/SwissProt for PRICKLE3 Gene

Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with PRICKLE3: view

Expression partners for PRICKLE3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRICKLE3 Gene

Orthologs for PRICKLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRICKLE3 35
  • 88.1 (n)
  • 88.93 (a)
LMO6 36
  • 91 (a)
(Canis familiaris)
Mammalia PRICKLE3 35
  • 85.36 (n)
  • 87.31 (a)
  • 88 (a)
(Mus musculus)
Mammalia Prickle3 35
  • 87.39 (n)
  • 92.91 (a)
Prickle3 16
Prickle3 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Prickle3 35
  • 88.07 (n)
  • 93.05 (a)
(Ornithorhynchus anatinus)
Mammalia PRICKLE3 36
  • 88 (a)
(Anolis carolinensis)
Reptilia PRICKLE3 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prickle3 35
  • 60.14 (n)
  • 57.61 (a)
(Danio rerio)
Actinopterygii prickle3 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta esn 36
  • 22 (a)
pk 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea prkl-1 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for PRICKLE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRICKLE3 Gene

Gene Tree for PRICKLE3 (if available)
Gene Tree for PRICKLE3 (if available)

Paralogs for PRICKLE3 Gene

Paralogs for PRICKLE3 Gene

genes like me logo Genes that share paralogs with PRICKLE3: view

Variants for PRICKLE3 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2856746 -- 49,185,847(+) agtga(A/G)cggag intron-variant, upstream-variant-2KB
rs3810680 -- 49,186,964(-) GGGGA(A/G)AGAGG upstream-variant-2KB
rs5953274 -- 49,186,974(+) CTCAT(C/T)CTTAT upstream-variant-2KB
rs6520403 -- 49,184,349(+) GCTCA(A/C/G/T)AGTTA intron-variant
rs7052642 -- 49,186,555(+) GCGGG(A/G)CGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE3 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv7442 OTHER Inversion 18451855
nsv205 OTHER Inversion 15895083

Relevant External Links for PRICKLE3 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Disorders for PRICKLE3 Gene

No disorders were found for PRICKLE3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PRICKLE3 Gene

Publications for PRICKLE3 Gene

  1. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PMID: 9344658) Fisher S.E. … Craig I.W. (Genomics 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for PRICKLE3 Gene

Sources for PRICKLE3 Gene

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