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Aliases for PRICKLE3 Gene

Aliases for PRICKLE3 Gene

  • Prickle Homolog 3 (Drosophila) 2 3
  • LMO6 3 4 6
  • Triple LIM Domain Protein 6 3 4
  • LIM Domain Only Protein 6 3 4
  • LMO-6 3 4
  • Prickle-Like Protein 3 3
  • LIM Domain Only 6 2

External Ids for PRICKLE3 Gene

Previous Symbols for PRICKLE3 Gene

  • LMO6

Summaries for PRICKLE3 Gene

Entrez Gene Summary for PRICKLE3 Gene

  • LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRICKLE3 Gene

PRICKLE3 (Prickle Homolog 3 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is PRICKLE1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE3 Gene

Genomics for PRICKLE3 Gene

Genomic Location for PRICKLE3 Gene

Start:
49,175,197 bp from pter
End:
49,186,528 bp from pter
Size:
11,332 bases
Orientation:
Minus strand

Genomic View for PRICKLE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRICKLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE3 Gene

Regulatory Elements for PRICKLE3 Gene

Proteins for PRICKLE3 Gene

  • Protein details for PRICKLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43900-PRIC3_HUMAN
    Recommended name:
    Prickle-like protein 3
    Protein Accession:
    O43900
    Secondary Accessions:
    • B7Z8F2
    • O76007
    • Q53XR5

    Protein attributes for PRICKLE3 Gene

    Size:
    615 amino acids
    Molecular mass:
    68609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE3 Gene

Proteomics data for PRICKLE3 Gene at MOPED

Post-translational modifications for PRICKLE3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys126

Other Protein References for PRICKLE3 Gene

No data available for DME Specific Peptides for PRICKLE3 Gene

Domains for PRICKLE3 Gene

Protein Domains for PRICKLE3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PRIC3_HUMAN
Domain:
  • Contains 3 LIM zinc-binding domains.:
    • O43900
  • Contains 1 PET domain.:
    • O43900
Family:
  • Belongs to the prickle / espinas / testin family.:
    • O43900
genes like me logo Genes that share domains with PRICKLE3: view

No data available for Gene Families for PRICKLE3 Gene

Function for PRICKLE3 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE3: view

Phenotypes for PRICKLE3 Gene

genes like me logo Genes that share phenotypes with PRICKLE3: view

miRNA for PRICKLE3 Gene

miRTarBase miRNAs that target PRICKLE3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRICKLE3 Gene

Localization for PRICKLE3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRICKLE3 Gene COMPARTMENTS Subcellular localization image for PRICKLE3 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PRICKLE3: view

Pathways for PRICKLE3 Gene

SuperPathways for PRICKLE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE3: view

No data available for Pathways by source for PRICKLE3 Gene

Transcripts for PRICKLE3 Gene

Unigene Clusters for PRICKLE3 Gene

Prickle homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: -

Relevant External Links for PRICKLE3 Gene

GeneLoc Exon Structure for
PRICKLE3
ECgene alternative splicing isoforms for
PRICKLE3

Expression for PRICKLE3 Gene

mRNA expression in normal human tissues for PRICKLE3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRICKLE3 Gene

SOURCE GeneReport for Unigene cluster for PRICKLE3 Gene Hs.732712

mRNA Expression by UniProt/SwissProt for PRICKLE3 Gene

O43900-PRIC3_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with PRICKLE3: view

Orthologs for PRICKLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMO6 37
  • 91 (a)
OneToOne
PRICKLE3 36
  • 88.1 (n)
  • 88.93 (a)
dog
(Canis familiaris)
Mammalia PRICKLE3 36
  • 85.36 (n)
  • 87.31 (a)
PRICKLE3 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prickle3 36
  • 87.39 (n)
  • 92.91 (a)
Prickle3 16
Prickle3 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRICKLE3 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prickle3 36
  • 88.07 (n)
  • 93.05 (a)
lizard
(Anolis carolinensis)
Reptilia PRICKLE3 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prickle3 36
  • 60.14 (n)
  • 57.61 (a)
zebrafish
(Danio rerio)
Actinopterygii prickle3 37
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta esn 37
  • 22 (a)
ManyToMany
pk 37
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea prkl-1 37
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
OneToMany
Species with no ortholog for PRICKLE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRICKLE3 Gene

ENSEMBL:
Gene Tree for PRICKLE3 (if available)
TreeFam:
Gene Tree for PRICKLE3 (if available)

Paralogs for PRICKLE3 Gene

Paralogs for PRICKLE3 Gene

genes like me logo Genes that share paralogs with PRICKLE3: view

Variants for PRICKLE3 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2856746 -- 49,185,847(+) agtga(A/G)cggag intron-variant, upstream-variant-2KB
rs3810680 -- 49,186,964(-) GGGGA(A/G)AGAGG upstream-variant-2KB
rs5953274 -- 49,186,974(+) CTCAT(C/T)CTTAT upstream-variant-2KB
rs6520403 -- 49,184,349(+) GCTCA(A/C/G/T)AGTTA intron-variant
rs7052642 -- 49,186,555(+) GCGGG(A/G)CGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE3 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv7442 OTHER Inversion 18451855
nsv205 OTHER Inversion 15895083

Relevant External Links for PRICKLE3 Gene

HapMap Linkage Disequilibrium report
PRICKLE3
Locus Specific Mutation Databases (LSDB)
PRICKLE3

Disorders for PRICKLE3 Gene

No disorders were found for PRICKLE3 Gene.

No data available for UniProtKB/Swiss-Prot for PRICKLE3 Gene

Publications for PRICKLE3 Gene

  1. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PMID: 9344658) Fisher S.E. … Craig I.W. (Genomics 1997) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for PRICKLE3 Gene

Sources for PRICKLE3 Gene

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