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Aliases for PRICKLE3 Gene

Aliases for PRICKLE3 Gene

  • Prickle Planar Cell Polarity Protein 3 2 3
  • Triple LIM Domain Protein 6 3 4
  • LIM Domain Only Protein 6 3 4
  • Prickle Homolog 3 3 5
  • LMO-6 3 4
  • LMO6 3 4
  • Prickle Homolog 3 (Drosophila) 2
  • LIM Domain Only 6 2

External Ids for PRICKLE3 Gene

Previous HGNC Symbols for PRICKLE3 Gene

  • LMO6

Previous GeneCards Identifiers for PRICKLE3 Gene

  • GC0XM048919
  • GC0XM049031
  • GC0XM046689

Summaries for PRICKLE3 Gene

Entrez Gene Summary for PRICKLE3 Gene

  • LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRICKLE3 Gene

PRICKLE3 (Prickle Planar Cell Polarity Protein 3) is a Protein Coding gene. Diseases associated with PRICKLE3 include aland island eye disease and congenital stationary night blindness. An important paralog of this gene is PRICKLE2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE3 Gene

Genomics for PRICKLE3 Gene

Regulatory Elements for PRICKLE3 Gene

Promoters for PRICKLE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRICKLE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRICKLE3 Gene

Chromosome:
X
Start:
49,174,841 bp from pter
End:
49,186,528 bp from pter
Size:
11,688 bases
Orientation:
Minus strand

Genomic View for PRICKLE3 Gene

Genes around PRICKLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRICKLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRICKLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE3 Gene

Proteins for PRICKLE3 Gene

  • Protein details for PRICKLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43900-PRIC3_HUMAN
    Recommended name:
    Prickle-like protein 3
    Protein Accession:
    O43900
    Secondary Accessions:
    • B7Z8F2
    • O76007
    • Q53XR5

    Protein attributes for PRICKLE3 Gene

    Size:
    615 amino acids
    Molecular mass:
    68609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE3 Gene

Proteomics data for PRICKLE3 Gene at MOPED

Post-translational modifications for PRICKLE3 Gene

  • Ubiquitination at Lys 126
  • Modification sites at PhosphoSitePlus

Other Protein References for PRICKLE3 Gene

Antibody Products

No data available for DME Specific Peptides for PRICKLE3 Gene

Domains & Families for PRICKLE3 Gene

Protein Domains for PRICKLE3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PRICKLE3 Gene

Graphical View of Domain Structure for InterPro Entry

O43900

UniProtKB/Swiss-Prot:

PRIC3_HUMAN :
  • Contains 3 LIM zinc-binding domains.
  • Belongs to the prickle / espinas / testin family.
Domain:
  • Contains 3 LIM zinc-binding domains.
  • Contains 1 PET domain.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE3: view

Function for PRICKLE3 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with PRICKLE3: view
genes like me logo Genes that share phenotypes with PRICKLE3: view

Animal Model Products

CRISPR Products

miRNA for PRICKLE3 Gene

miRTarBase miRNAs that target PRICKLE3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRICKLE3 Gene

Localization for PRICKLE3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRICKLE3 Gene COMPARTMENTS Subcellular localization image for PRICKLE3 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRICKLE3 Gene

Pathways & Interactions for PRICKLE3 Gene

SuperPathways for PRICKLE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRICKLE3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRICKLE3 Gene

Drugs & Compounds for PRICKLE3 Gene

No Compound Related Data Available

Transcripts for PRICKLE3 Gene

Unigene Clusters for PRICKLE3 Gene

Prickle homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: -

Relevant External Links for PRICKLE3 Gene

GeneLoc Exon Structure for
PRICKLE3
ECgene alternative splicing isoforms for
PRICKLE3

Expression for PRICKLE3 Gene

mRNA expression in normal human tissues for PRICKLE3 Gene

Protein differential expression in normal tissues from HIPED for PRICKLE3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRICKLE3 Gene



SOURCE GeneReport for Unigene cluster for PRICKLE3 Gene Hs.732712

mRNA Expression by UniProt/SwissProt for PRICKLE3 Gene

O43900-PRIC3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PRICKLE3: view

Protein tissue co-expression partners for PRICKLE3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRICKLE3 Gene

Orthologs for PRICKLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRICKLE3 35
  • 88.1 (n)
  • 88.93 (a)
LMO6 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRICKLE3 36
  • 88 (a)
OneToOne
PRICKLE3 35
  • 85.36 (n)
  • 87.31 (a)
mouse
(Mus musculus)
Mammalia Prickle3 16
Prickle3 36
  • 87 (a)
OneToOne
Prickle3 35
  • 87.39 (n)
  • 92.91 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PRICKLE3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prickle3 35
  • 88.07 (n)
  • 93.05 (a)
lizard
(Anolis carolinensis)
Reptilia PRICKLE3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prickle3 35
  • 60.14 (n)
  • 57.61 (a)
zebrafish
(Danio rerio)
Actinopterygii prickle3 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta esn 36
  • 22 (a)
ManyToMany
pk 36
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea prkl-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for PRICKLE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRICKLE3 Gene

ENSEMBL:
Gene Tree for PRICKLE3 (if available)
TreeFam:
Gene Tree for PRICKLE3 (if available)

Paralogs for PRICKLE3 Gene

Paralogs for PRICKLE3 Gene

genes like me logo Genes that share paralogs with PRICKLE3: view

Variants for PRICKLE3 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036188 A breast cancer sample
rs7065449 - 49,177,131(+) ACAGC(A/G)ACTAC reference, missense
rs2856746 -- 49,185,847(+) agtga(A/G)cggag intron-variant, upstream-variant-2KB
rs4824745 -- 49,182,527(+) gcaca(C/T)gcctg intron-variant
rs5952517 -- 49,183,061(+) tcaag(C/T)aatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE3 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV Gain+Loss 17666407
nsv528292 CNV Gain 19592680
nsv7442 OTHER Inversion 18451855
nsv205 OTHER Inversion 15895083

Variation tolerance for PRICKLE3 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRICKLE3 Gene

HapMap Linkage Disequilibrium report
PRICKLE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Disorders for PRICKLE3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRICKLE3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aland island eye disease
  • forsius-eriksson syndrome
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRICKLE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRICKLE3
genes like me logo Genes that share disorders with PRICKLE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRICKLE3 Gene

Publications for PRICKLE3 Gene

  1. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PMID: 9344658) Fisher S.E. … Craig I.W. (Genomics 1997) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  4. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for PRICKLE3 Gene

Sources for PRICKLE3 Gene

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