Aliases for PRICKLE3 Gene
External Ids for PRICKLE3 Gene
Previous HGNC Symbols for PRICKLE3 Gene
Previous GeneCards Identifiers for PRICKLE3 Gene
LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRICKLE3 Gene
PRICKLE3 (Prickle Planar Cell Polarity Protein 3) is a Protein Coding gene. Diseases associated with PRICKLE3 include Aland Island Eye Disease and Congenital Stationary Night Blindness. An important paralog of this gene is PRICKLE2.
UniProtKB/Swiss-Prot for PRICKLE3 Gene
Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).