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Aliases for PRICKLE3 Gene

Aliases for PRICKLE3 Gene

  • Prickle Planar Cell Polarity Protein 3 2 3 5
  • Triple LIM Domain Protein 6 3 4
  • LIM Domain Only Protein 6 3 4
  • LMO-6 3 4
  • LMO6 3 4
  • Prickle Homolog 3 (Drosophila) 2
  • Prickle-Like Protein 3 3
  • LIM Domain Only 6 2
  • Prickle Homolog 3 3

External Ids for PRICKLE3 Gene

Previous HGNC Symbols for PRICKLE3 Gene

  • LMO6

Previous GeneCards Identifiers for PRICKLE3 Gene

  • GC0XM048919
  • GC0XM049031
  • GC0XM046689

Summaries for PRICKLE3 Gene

Entrez Gene Summary for PRICKLE3 Gene

  • LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRICKLE3 Gene

PRICKLE3 (Prickle Planar Cell Polarity Protein 3) is a Protein Coding gene. Diseases associated with PRICKLE3 include Aland Island Eye Disease and Congenital Stationary Night Blindness. An important paralog of this gene is PRICKLE2.

Additional gene information for PRICKLE3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE3 Gene

Genomics for PRICKLE3 Gene

Regulatory Elements for PRICKLE3 Gene

Enhancers for PRICKLE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH049188 1.3 Ensembl ENCODE 18.8 -3.9 -3943 4.3 HDGF PKNOX1 ATF1 ZNF133 ARID4B SIN3A ZBTB7B TCF12 ZNF121 GLIS2 PRICKLE3 CACNA1F PLP2 ENSG00000204620 SYP-AS1
GH0XH048573 1.1 ENCODE 18.1 +611.5 611542 3.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS ZNF182 ENSG00000228343 ENSG00000204620 FTSJ1 ZNF81 PRICKLE3 PQBP1 ENSG00000270012 HDAC6 PLP2
GH0XH048596 1.1 ENCODE 18.1 +588.9 588877 2.6 FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SP3 SP5 PRICKLE3 ENSG00000228343 PLP2 WDR13 VN1R110P
GH0XH049266 1 ENCODE 18.3 -82.3 -82282 4.7 HDGF PKNOX1 ATF1 SIN3A GLI4 BRCA1 ZNF2 YY1 GLIS2 ZNF143 ENSG00000204620 FTSJ1 PRICKLE3 ENSG00000270012 RBM3 PLP2 CACNA1F USP27X-AS1 FOXP3 CCDC22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRICKLE3 on UCSC Golden Path with GeneCards custom track

Promoters for PRICKLE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246561 1028 2201 ATF1 ARID4B SIN3A ZNF2 GLIS2 ZNF143 ZNF207 FOS ATF7 RUNX3

Genomic Locations for PRICKLE3 Gene

Genomic Locations for PRICKLE3 Gene
11,688 bases
Minus strand

Genomic View for PRICKLE3 Gene

Genes around PRICKLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRICKLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRICKLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE3 Gene

Proteins for PRICKLE3 Gene

  • Protein details for PRICKLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prickle-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B7Z8F2
    • O76007
    • Q53XR5

    Protein attributes for PRICKLE3 Gene

    615 amino acids
    Molecular mass:
    68609 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PRICKLE3 Gene


neXtProt entry for PRICKLE3 Gene

Post-translational modifications for PRICKLE3 Gene

  • Ubiquitination at isoforms=126
  • Modification sites at PhosphoSitePlus

Other Protein References for PRICKLE3 Gene

No data available for DME Specific Peptides for PRICKLE3 Gene

Domains & Families for PRICKLE3 Gene

Gene Families for PRICKLE3 Gene

Suggested Antigen Peptide Sequences for PRICKLE3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the prickle / espinas / testin family.
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE3: view

Function for PRICKLE3 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE3: view
genes like me logo Genes that share phenotypes with PRICKLE3: view

Animal Model Products

miRNA for PRICKLE3 Gene

miRTarBase miRNAs that target PRICKLE3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRICKLE3 Gene

Localization for PRICKLE3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRICKLE3 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PRICKLE3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Pathways & Interactions for PRICKLE3 Gene

SuperPathways for PRICKLE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRICKLE3: view

No data available for Pathways by source and SIGNOR curated interactions for PRICKLE3 Gene

Drugs & Compounds for PRICKLE3 Gene

No Compound Related Data Available

Transcripts for PRICKLE3 Gene

Unigene Clusters for PRICKLE3 Gene

Prickle homolog 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP6: -

Relevant External Links for PRICKLE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRICKLE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRICKLE3 Gene

Protein differential expression in normal tissues from HIPED for PRICKLE3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRICKLE3 Gene

Protein tissue co-expression partners for PRICKLE3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRICKLE3 Gene:


SOURCE GeneReport for Unigene cluster for PRICKLE3 Gene:


mRNA Expression by UniProt/SwissProt for PRICKLE3 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PRICKLE3 Gene

  • Heart(4.1)
  • Intestine(4.1)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with PRICKLE3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRICKLE3 Gene

Orthologs for PRICKLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LMO6 34
  • 91 (a)
  • 88.1 (n)
(Rattus norvegicus)
Mammalia Prickle3 33
  • 88.07 (n)
(Ornithorhynchus anatinus)
Mammalia PRICKLE3 34
  • 88 (a)
(Mus musculus)
Mammalia Prickle3 33 16 34
  • 87.39 (n)
(Canis familiaris)
Mammalia PRICKLE3 33 34
  • 85.36 (n)
(Anolis carolinensis)
Reptilia PRICKLE3 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prickle3 33
  • 60.14 (n)
(Danio rerio)
Actinopterygii prickle3 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta esn 34
  • 22 (a)
pk 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea prkl-1 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for PRICKLE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRICKLE3 Gene

Gene Tree for PRICKLE3 (if available)
Gene Tree for PRICKLE3 (if available)

Paralogs for PRICKLE3 Gene

Paralogs for PRICKLE3 Gene

genes like me logo Genes that share paralogs with PRICKLE3: view

Variants for PRICKLE3 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036188 A breast cancer sample
rs181070015 Likely benign 49,188,048(+) CAGGA(C/T)GGGTG upstream-variant-2KB, utr-variant-3-prime
rs781914486 Likely benign 49,188,156(+) CATCA(C/T)GGGAG upstream-variant-2KB, utr-variant-3-prime
rs782190288 Likely benign 49,188,159(+) CACGG(C/G)AGTGG upstream-variant-2KB, utr-variant-3-prime
rs782481686 Likely benign 49,188,318(+) CTATC(C/T)AAGTC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE3 Gene

Variant ID Type Subtype PubMed ID
nsv7442 OTHER inversion 18451855
nsv528292 CNV gain 19592680
nsv205 OTHER inversion 15895083
esv32909 CNV gain+loss 17666407

Variation tolerance for PRICKLE3 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRICKLE3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Disorders for PRICKLE3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRICKLE3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
aland island eye disease
  • forsius-eriksson syndrome
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRICKLE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRICKLE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRICKLE3 Gene

Publications for PRICKLE3 Gene

  1. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PMID: 9344658) Fisher SE … Craig IW (Genomics 1997) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 60

Products for PRICKLE3 Gene

Sources for PRICKLE3 Gene

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