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Aliases for PRICKLE3 Gene

Aliases for PRICKLE3 Gene

  • Prickle Planar Cell Polarity Protein 3 2 3 5
  • Triple LIM Domain Protein 6 3 4
  • LIM Domain Only Protein 6 3 4
  • Prickle-Like Protein 3 3 4
  • LMO-6 3 4
  • LMO6 3 4
  • PK3 3 4
  • Prickle Homolog 3 (Drosophila) 2
  • LIM Domain Only 6 2
  • Prickle Homolog 3 3

External Ids for PRICKLE3 Gene

Previous HGNC Symbols for PRICKLE3 Gene

  • LMO6

Previous GeneCards Identifiers for PRICKLE3 Gene

  • GC0XM048919
  • GC0XM049031
  • GC0XM046689

Summaries for PRICKLE3 Gene

Entrez Gene Summary for PRICKLE3 Gene

  • LIM domain only 6 is a three LIM domain-containing protein. The LIM domain is a cysteine-rich sequence motif that binds zinc atoms to form a specific protein-binding interface for protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRICKLE3 Gene

PRICKLE3 (Prickle Planar Cell Polarity Protein 3) is a Protein Coding gene. Diseases associated with PRICKLE3 include Aland Island Eye Disease and Congenital Stationary Night Blindness. An important paralog of this gene is PRICKLE2.

UniProtKB/Swiss-Prot for PRICKLE3 Gene

  • Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).

Additional gene information for PRICKLE3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE3 Gene

Genomics for PRICKLE3 Gene

GeneHancer (GH) Regulatory Elements for PRICKLE3 Gene

Promoters and enhancers for PRICKLE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI049183 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 615 4 PKNOX1 CLOCK ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 ZNF207 ZNF143 PRICKLE3 PRAF2 CACNA1F PLP2 SYP
GH0XI048799 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.1 +385.0 385019 4 HDGF PKNOX1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF766 HDAC6 CCDC22 PRICKLE3 ENSG00000270012 ERAS ENSG00000204620 ZNF81 PLP2 FTSJ1 RBM3
GH0XI048573 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 +611.5 611542 3.4 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 ENSG00000204620 RBM3 ZNF182 ENSG00000228343 FTSJ1 ZNF81 PRICKLE3 PQBP1 ENSG00000270012 HDAC6
GH0XI049266 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.3 -82.3 -82281 4.7 HDGF PKNOX1 SIN3A ZNF2 YY1 POLR2B E2F8 ZNF143 FOS KLF13 PPP1R3F FOXP3 ENSG00000204620 FTSJ1 PRICKLE3 ENSG00000270012 RBM3 PLP2 CACNA1F USP27X-AS1
GH0XI048596 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.1 +588.9 588877 2.6 FOXA2 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B WDR13 PRICKLE3 ENSG00000228343 PLP2 VN1R110P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRICKLE3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRICKLE3 gene promoter:

Genomic Locations for PRICKLE3 Gene

Genomic Locations for PRICKLE3 Gene
chrX:49,174,841-49,186,528
(GRCh38/hg38)
Size:
11,688 bases
Orientation:
Minus strand
chrX:49,031,151-49,042,845
(GRCh37/hg19)

Genomic View for PRICKLE3 Gene

Genes around PRICKLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRICKLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRICKLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE3 Gene

Proteins for PRICKLE3 Gene

  • Protein details for PRICKLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43900-PRIC3_HUMAN
    Recommended name:
    Prickle planar cell polarity protein 3
    Protein Accession:
    O43900
    Secondary Accessions:
    • B7Z8F2
    • O76007
    • Q53XR5

    Protein attributes for PRICKLE3 Gene

    Size:
    615 amino acids
    Molecular mass:
    68609 Da
    Quaternary structure:
    • Interacts with VANGL2 via its C-terminus (By similarity). The VANGL2-dependent membrane recruitment of PRICKLE3 is a prerequisite for its polarization (By similarity). Interacts with WTIP. WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity).

    Alternative splice isoforms for PRICKLE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRICKLE3 Gene

Post-translational modifications for PRICKLE3 Gene

Other Protein References for PRICKLE3 Gene

No data available for DME Specific Peptides for PRICKLE3 Gene

Domains & Families for PRICKLE3 Gene

Gene Families for PRICKLE3 Gene

Suggested Antigen Peptide Sequences for PRICKLE3 Gene

Graphical View of Domain Structure for InterPro Entry

O43900

UniProtKB/Swiss-Prot:

PRIC3_HUMAN :
  • Belongs to the prickle / espinas / testin family.
Family:
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE3: view

Function for PRICKLE3 Gene

Molecular function for PRICKLE3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).

Gene Ontology (GO) - Molecular Function for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE3: view
genes like me logo Genes that share phenotypes with PRICKLE3: view

Animal Model Products

miRNA for PRICKLE3 Gene

miRTarBase miRNAs that target PRICKLE3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRICKLE3 Gene

Localization for PRICKLE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited by VANGL2 to anterior cell borders. This polarity is controlled by Wnt proteins (By similarity). WTIP is involved in the recruitment of PRICKLE3 to the basal body (By similarity). {ECO:0000250 UniProtKB:A8WH69}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRICKLE3 gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PRICKLE3: view

Pathways & Interactions for PRICKLE3 Gene

SuperPathways for PRICKLE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRICKLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with PRICKLE3: view

No data available for Pathways by source and SIGNOR curated interactions for PRICKLE3 Gene

Drugs & Compounds for PRICKLE3 Gene

No Compound Related Data Available

Transcripts for PRICKLE3 Gene

Unigene Clusters for PRICKLE3 Gene

Prickle homolog 3 (Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: -

Relevant External Links for PRICKLE3 Gene

GeneLoc Exon Structure for
PRICKLE3
ECgene alternative splicing isoforms for
PRICKLE3

Expression for PRICKLE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRICKLE3 Gene

Protein differential expression in normal tissues from HIPED for PRICKLE3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRICKLE3 Gene



Protein tissue co-expression partners for PRICKLE3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRICKLE3 Gene:

PRICKLE3

SOURCE GeneReport for Unigene cluster for PRICKLE3 Gene:

Hs.732712

mRNA Expression by UniProt/SwissProt for PRICKLE3 Gene:

O43900-PRIC3_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PRICKLE3 Gene

  • Heart(4.1)
  • Intestine(4.1)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with PRICKLE3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRICKLE3 Gene

Orthologs for PRICKLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LMO6 34
  • 91 (a)
OneToOne
PRICKLE3 33
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Prickle3 33
  • 88.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRICKLE3 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prickle3 33 16 34
  • 87.39 (n)
dog
(Canis familiaris)
Mammalia PRICKLE3 33 34
  • 85.36 (n)
lizard
(Anolis carolinensis)
Reptilia PRICKLE3 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prickle3 33
  • 60.14 (n)
zebrafish
(Danio rerio)
Actinopterygii prickle3 34
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta esn 34
  • 22 (a)
ManyToMany
pk 34
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea prkl-1 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for PRICKLE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRICKLE3 Gene

ENSEMBL:
Gene Tree for PRICKLE3 (if available)
TreeFam:
Gene Tree for PRICKLE3 (if available)

Paralogs for PRICKLE3 Gene

Paralogs for PRICKLE3 Gene

genes like me logo Genes that share paralogs with PRICKLE3: view

Variants for PRICKLE3 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057519388 uncertain-significance, Progressive sensorineural hearing impairment 49,178,431(-) G/T coding_sequence_variant, missense_variant
rs17144222 benign, Non-syndromic X-linked intellectual disability 49,188,232(-) G/A upstream_transcript_variant
rs181070015 likely-benign, Non-syndromic X-linked intellectual disability 49,188,048(-) C/T upstream_transcript_variant
rs781914486 likely-benign, Non-syndromic X-linked intellectual disability 49,188,156(-) C/T upstream_transcript_variant
rs782190288 likely-benign, Non-syndromic X-linked intellectual disability 49,188,159(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE3 Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
nsv205 OTHER inversion 15895083
nsv528292 CNV gain 19592680
nsv7442 OTHER inversion 18451855

Variation tolerance for PRICKLE3 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRICKLE3 Gene

Human Gene Mutation Database (HGMD)
PRICKLE3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRICKLE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE3 Gene

Disorders for PRICKLE3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRICKLE3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
aland island eye disease
  • aied
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PRICKLE3

genes like me logo Genes that share disorders with PRICKLE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRICKLE3 Gene

Publications for PRICKLE3 Gene

  1. Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp. (PMID: 9344658) Fisher SE … Craig IW (Genomics 1997) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58

Products for PRICKLE3 Gene

Sources for PRICKLE3 Gene

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