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Aliases for PRICKLE2 Gene

Aliases for PRICKLE2 Gene

  • Prickle Homolog 2 (Drosophila) 2 3
  • EPM5 3 6
  • Prickle-Like 2 (Drosophila) 2
  • Prickle-Like Protein 2 3

External Ids for PRICKLE2 Gene

Previous GeneCards Identifiers for PRICKLE2 Gene

  • GC03M063482
  • GC03M063934
  • GC03M064036
  • GC03M064054

Summaries for PRICKLE2 Gene

Entrez Gene Summary for PRICKLE2 Gene

  • This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRICKLE2 Gene

PRICKLE2 (Prickle Homolog 2 (Drosophila)) is a Protein Coding gene. Diseases associated with PRICKLE2 include epilepsy, progressive myoclonic 5. Among its related pathways are Wnt signaling pathway (KEGG). An important paralog of this gene is PRICKLE3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRICKLE2 Gene

Genomics for PRICKLE2 Gene

Regulatory Elements for PRICKLE2 Gene

Genomic Location for PRICKLE2 Gene

64,093,850 bp from pter
64,445,476 bp from pter
351,627 bases
Minus strand

Genomic View for PRICKLE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRICKLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRICKLE2 Gene

Proteins for PRICKLE2 Gene

  • Protein details for PRICKLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prickle-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q0VF44

    Protein attributes for PRICKLE2 Gene

    844 amino acids
    Molecular mass:
    95615 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRICKLE2 Gene

Proteomics data for PRICKLE2 Gene at MOPED

Post-translational modifications for PRICKLE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRICKLE2 Gene

Antibody Products

No data available for DME Specific Peptides for PRICKLE2 Gene

Domains for PRICKLE2 Gene

Protein Domains for PRICKLE2 Gene


Suggested Antigen Peptide Sequences for PRICKLE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z3G6
  • Contains 3 LIM zinc-binding domains.
  • Contains 1 PET domain.
  • Belongs to the prickle / espinas / testin family.
genes like me logo Genes that share domains with PRICKLE2: view

No data available for Gene Families for PRICKLE2 Gene

Function for PRICKLE2 Gene

Gene Ontology (GO) - Molecular Function for PRICKLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PRICKLE2: view

Phenotypes for PRICKLE2 Gene

genes like me logo Genes that share phenotypes with PRICKLE2: view

Animal Models for PRICKLE2 Gene

MGI Knock Outs for PRICKLE2:

Animal Model Products

CRISPR Products

miRNA for PRICKLE2 Gene

miRTarBase miRNAs that target PRICKLE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRICKLE2 Gene

Localization for PRICKLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRICKLE2 Gene

Nucleus membrane.

Subcellular locations from

Jensen Localization Image for PRICKLE2 Gene COMPARTMENTS Subcellular localization image for PRICKLE2 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRICKLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0016327 apicolateral plasma membrane IEA --
GO:0016328 lateral plasma membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with PRICKLE2: view

Pathways for PRICKLE2 Gene

SuperPathways for PRICKLE2 Gene

Superpath Contained pathways
1 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with PRICKLE2: view

Pathways by source for PRICKLE2 Gene

1 KEGG pathway for PRICKLE2 Gene

Gene Ontology (GO) - Biological Process for PRICKLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031175 neuron projection development IEA --
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IEA --
genes like me logo Genes that share ontologies with PRICKLE2: view

Transcripts for PRICKLE2 Gene

Unigene Clusters for PRICKLE2 Gene

Prickle homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRICKLE2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRICKLE2 Gene

No ASD Table

Relevant External Links for PRICKLE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRICKLE2 Gene

mRNA expression in normal human tissues for PRICKLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PRICKLE2 Gene

This gene is overexpressed in Ovary (54.8) and Fetal Brain (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRICKLE2 Gene

SOURCE GeneReport for Unigene cluster for PRICKLE2 Gene Hs.148105

mRNA Expression by UniProt/SwissProt for PRICKLE2 Gene

Tissue specificity: Expressed in brain, eye and testis. Additionally in fetal brain, adult cartilage, pancreatic islet, gastric cancer and uterus tumors.
genes like me logo Genes that share expressions with PRICKLE2: view

Expression partners for PRICKLE2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRICKLE2 Gene

Orthologs for PRICKLE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRICKLE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PRICKLE2 35
  • 89.61 (n)
  • 95.38 (a)
  • 94 (a)
(Canis familiaris)
Mammalia PRICKLE2 35
  • 90.28 (n)
  • 95.85 (a)
  • 96 (a)
(Mus musculus)
Mammalia Prickle2 35
  • 89.45 (n)
  • 95.26 (a)
Prickle2 16
Prickle2 36
  • 89 (a)
(Pan troglodytes)
Mammalia PRICKLE2 35
  • 99.57 (n)
  • 99.88 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Prickle2 35
  • 89.26 (n)
  • 95.26 (a)
(Monodelphis domestica)
Mammalia PRICKLE2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia PRICKLE2 36
  • 92 (a)
(Gallus gallus)
Aves PRICKLE2 35
  • 80.05 (n)
  • 86.78 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia PRICKLE2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prickle2 35
  • 77.8 (n)
  • 91.29 (a)
(Danio rerio)
Actinopterygii prickle2 35
  • 65.22 (n)
  • 68.6 (a)
prickle2 36
  • 68 (a)
PRICKLE2 (1 of 2) 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta esn 36
  • 24 (a)
pk 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea prkl-1 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for PRICKLE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRICKLE2 Gene

Gene Tree for PRICKLE2 (if available)
Gene Tree for PRICKLE2 (if available)

Paralogs for PRICKLE2 Gene

Paralogs for PRICKLE2 Gene

Selected SIMAP similar genes for PRICKLE2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRICKLE2: view

Variants for PRICKLE2 Gene

Sequence variations from dbSNP and Humsavar for PRICKLE2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs26933 -- 64,168,419(+) AGTTT(A/G)TGCAT intron-variant
rs26934 -- 64,169,322(+) TGAGC(A/C)TGGAC intron-variant
rs26940 -- 64,148,680(+) gtgga(G/T)acctc intron-variant
rs26941 -- 64,150,434(+) ATTGC(A/G)TTAGG intron-variant
rs26942 -- 64,160,237(+) GTGAG(A/T)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRICKLE2 Gene

Variant ID Type Subtype PubMed ID
nsv834717 CNV Gain 17160897
nsv522355 CNV Loss 19592680
dgv288n21 CNV Loss 19592680
nsv822111 CNV Loss 20364138
nsv518137 CNV Loss 19592680
nsv876887 CNV Loss 21882294
nsv528206 CNV Loss 19592680
nsv515640 CNV Gain 19592680
nsv3851 CNV Loss 18451855

Relevant External Links for PRICKLE2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRICKLE2 Gene

Disorders for PRICKLE2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PRICKLE2 Gene in MalaCards »

(1) Diseases for PRICKLE2 Gene including...

(1) OMIM Diseases for PRICKLE2 Gene (608501)


  • Epilepsy, progressive myoclonic 5 (EPM5) [MIM:613832]: A neurodegenerative disorder characterized by myoclonic seizures and variable neurologic symptoms including cognitive decline and persistent movement abnormalities. {ECO:0000269 PubMed:21276947}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for PRICKLE2 Gene

Relevant External Links for PRICKLE2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PRICKLE2: view

No data available for Novoseek inferred disease relationships and Genatlas for PRICKLE2 Gene

Publications for PRICKLE2 Gene

  1. Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle. (PMID: 12525887) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 2 3 4 23
  2. Towards complete sets of farnesylated and geranylgeranylated proteins. (PMID: 17411337) Maurer-Stroh S. … Eisenhaber F. (PLoS Comput. Biol. 2007) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. (PMID: 19303062) Tanaka T. … Ferrucci L. (Am. J. Hum. Genet. 2009) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for PRICKLE2 Gene

Sources for PRICKLE2 Gene

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