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Aliases for PRH2 Gene

Aliases for PRH2 Gene

  • Proline-Rich Protein HaeIII Subfamily 2 2 3 5
  • Parotid Proline-Rich Protein 1/2 3 4
  • Parotid Double-Band Protein 3 4
  • Parotid Acidic Protein 3 4
  • PRP-1/PRP-2 3 4
  • Protein C 3 4
  • Pr1/Pr2 3 4
  • Acidic Salivary Proline-Rich Protein, HaeIII Type, 2 3
  • Parotid Isoelectric Focusing Variant Protein 4
  • Acidic Salivary Proline-Rich Protein 2
  • Parotid Proline-Rich Protein 2
  • HaeIII Type 2
  • PRH1 PRH2 4
  • PIF-S 4
  • Db-S 4
  • PA 4
  • PR 3
  • 2 2

External Ids for PRH2 Gene

Previous GeneCards Identifiers for PRH2 Gene

  • GC12U990080
  • GC12P011226
  • GC12P010982
  • GC12P010973
  • GC12P011081
  • GC12P010810

Summaries for PRH2 Gene

Entrez Gene Summary for PRH2 Gene

  • This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRH2 Gene

PRH2 (Proline-Rich Protein HaeIII Subfamily 2) is a Protein Coding gene. Among its related pathways are Salivary secretion. An important paralog of this gene is PRH1.

UniProtKB/Swiss-Prot for PRH2 Gene

  • PRPs act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRH2 Gene

Genomics for PRH2 Gene

Regulatory Elements for PRH2 Gene

Enhancers for PRH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRH2 Gene

Chromosome:
12
Start:
10,929,235 bp from pter
End:
10,934,845 bp from pter
Size:
5,611 bases
Orientation:
Plus strand

Genomic View for PRH2 Gene

Genes around PRH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRH2 Gene

Proteins for PRH2 Gene

  • Protein details for PRH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02810-PRPC_HUMAN
    Recommended name:
    Salivary acidic proline-rich phosphoprotein 1/2
    Protein Accession:
    P02810
    Secondary Accessions:
    • A2VCM0
    • A3KN66
    • A5D902
    • B2RMW2
    • Q4VBP2
    • Q53XA2
    • Q6P2F6

    Protein attributes for PRH2 Gene

    Size:
    166 amino acids
    Molecular mass:
    17016 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI28193.1; Type=Erroneous termination; Positions=167; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAI41917.1; Type=Erroneous termination; Positions=167; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for PRH2 Gene

Proteomics data for PRH2 Gene at MOPED

Post-translational modifications for PRH2 Gene

  • An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.
  • Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.
  • Glycosylation at Ser 33 and Ser 38
  • Modification sites at PhosphoSitePlus

Other Protein References for PRH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRH2 Gene

Domains & Families for PRH2 Gene

Gene Families for PRH2 Gene

Protein Domains for PRH2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRH2: view

No data available for UniProtKB/Swiss-Prot for PRH2 Gene

Function for PRH2 Gene

Molecular function for PRH2 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,acidic,Hae subfamily 2,see PR@ for references
UniProtKB/Swiss-Prot Function:
PRPs act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Phenotypes for PRH2 Gene

genes like me logo Genes that share phenotypes with PRH2: view

Animal Model Products

CRISPR Products

miRNA for PRH2 Gene

miRTarBase miRNAs that target PRH2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRH2 Gene

Localization for PRH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRH2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRH2 Gene COMPARTMENTS Subcellular localization image for PRH2 gene
Compartment Confidence
extracellular 5
chloroplast 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for PRH2 Gene

Pathways & Interactions for PRH2 Gene

SuperPathways for PRH2 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with PRH2: view

Pathways by source for PRH2 Gene

1 KEGG pathway for PRH2 Gene

Interacting Proteins for PRH2 Gene

SIGNOR curated interactions for PRH2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PRH2 Gene

None

Drugs & Compounds for PRH2 Gene

No Compound Related Data Available

Transcripts for PRH2 Gene

mRNA/cDNA for PRH2 Gene

Unigene Clusters for PRH2 Gene

Proline-rich protein HaeIII subfamily 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRH2 Gene

No ASD Table

Relevant External Links for PRH2 Gene

GeneLoc Exon Structure for
PRH2
ECgene alternative splicing isoforms for
PRH2

Expression for PRH2 Gene

mRNA expression in normal human tissues for PRH2 Gene

mRNA differential expression in normal tissues according to GTEx for PRH2 Gene

This gene is overexpressed in Esophagus - Mucosa (x30.5) and Testis (x8.0).

Protein differential expression in normal tissues from HIPED for PRH2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRH2 Gene



SOURCE GeneReport for Unigene cluster for PRH2 Gene Hs.408153

genes like me logo Genes that share expression patterns with PRH2: view

Protein tissue co-expression partners for PRH2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRH2 Gene

Orthologs for PRH2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRH2 35
  • 99.8 (n)
  • 99.4 (a)
PRH2 36
  • 100 (a)
OneToOne
Species with no ortholog for PRH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRH2 Gene

ENSEMBL:
Gene Tree for PRH2 (if available)
TreeFam:
Gene Tree for PRH2 (if available)

Paralogs for PRH2 Gene

Paralogs for PRH2 Gene

(1) SIMAP similar genes for PRH2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PRH2: view

Variants for PRH2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRH2 Gene

P02810-PRPC_HUMAN
Sequence shown is that of allele PRH2-2, also known as PR-2; Allele PRH2-1 is also known as PR-1 or protein C, and allele PRH2-3 as PR-1. The PRH1-DB allele (about 16% of the population) has an insertion of 21 repeated amino acids compared to the more frequent PRH1-PIF allele (68%). In contrast to all other PRH1 and PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved.

Structural Variations from Database of Genomic Variants (DGV) for PRH2 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
nsv898777 CNV Loss 21882294
essv11102 CNV CNV 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
nsv832330 CNV Gain 17160897

Variation tolerance for PRH2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRH2 Gene

HapMap Linkage Disequilibrium report
PRH2

No data available for Sequence variations from dbSNP and Humsavar for PRH2 Gene

Disorders for PRH2 Gene

Relevant External Links for PRH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRH2

No disorders were found for PRH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRH2 Gene

Publications for PRH2 Gene

  1. Structures of two HaeIII-type genes in the human salivary proline- rich protein multigene family. (PMID: 3009472) Kim H.-S. … Maeda N. (J. Biol. Chem. 1986) 2 3 4 67
  2. The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species. (PMID: 26375204) Manconi B. … Messana I. (J Proteomics 2016) 3
  3. Finding new posttranslational modifications in salivary proline-rich proteins. (PMID: 20879038) Vitorino R. … Amado F.L. (Proteomics 2010) 3
  4. Different isoforms and post-translational modifications of human salivary acidic proline-rich proteins. (PMID: 15693058) Inzitari R. … Messana I. (Proteomics 2005) 3
  5. Two-hybrid analysis of human salivary mucin MUC7 interactions. (PMID: 16203048) Bruno L.S. … Offner G.D. (Biochim. Biophys. Acta 2005) 3

Products for PRH2 Gene

Sources for PRH2 Gene

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