Aliases for PRH1 Gene
External Ids for PRH1 Gene
Previous GeneCards Identifiers for PRH1 Gene
This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
GeneCards Summary for PRH1 Gene
PRH1 (Proline Rich Protein HaeIII Subfamily 1) is a Protein Coding gene. Diseases associated with PRH1 include Dental Caries. Among its related pathways are Salivary secretion. An important paralog of this gene is ENSG00000275778.
UniProtKB/Swiss-Prot for PRH1 Gene
PRPs act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.