Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRH1 Gene

Aliases for PRH1 Gene

  • Proline Rich Protein HaeIII Subfamily 1 2 3 5
  • Parotid Isoelectric Focusing Variant Protein 3 4
  • Parotid Proline-Rich Protein 1/2 3 4
  • Parotid Double-Band Protein 3 4
  • Parotid Acidic Protein 3 4
  • PRP-1/PRP-2 3 4
  • Protein C 3 4
  • Pr1/Pr2 3 4
  • PIF-S 3 4
  • Db-S 3 4
  • PA 3 4
  • Salivary Acidic Proline-Rich Phosphoprotein 1/2 3
  • PRH1 PRH2 4
  • PRH2 3

External Ids for PRH1 Gene

Previous GeneCards Identifiers for PRH1 Gene

  • GC12P010785
  • GC12M011177
  • GC12M010898
  • GC12M010924
  • GC12M011033
  • GC12M010762

Summaries for PRH1 Gene

Entrez Gene Summary for PRH1 Gene

  • This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRH1 Gene

PRH1 (Proline Rich Protein HaeIII Subfamily 1) is a Protein Coding gene. Diseases associated with PRH1 include Dental Caries. Among its related pathways are Salivary secretion. An important paralog of this gene is ENSG00000275778.

UniProtKB/Swiss-Prot for PRH1 Gene

  • PRPs act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Gene Wiki entry for PRH1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRH1 Gene

Genomics for PRH1 Gene

Regulatory Elements for PRH1 Gene

Enhancers for PRH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G011307 0.3 FANTOM5 37.4 -136.1 -136114 0.1 PRB1 PRB4 PRB3 PRB2 PRH1 PRH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRH1 Gene

Chromosome:
12
Start:
10,824,960 bp from pter
End:
11,171,623 bp from pter
Size:
346,664 bases
Orientation:
Minus strand

Genomic View for PRH1 Gene

Genes around PRH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRH1 Gene

Proteins for PRH1 Gene

  • Protein details for PRH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02810-PRPC_HUMAN
    Recommended name:
    Salivary acidic proline-rich phosphoprotein 1/2
    Protein Accession:
    P02810
    Secondary Accessions:
    • A2VCM0
    • A3KN66
    • A5D902
    • B2RMW2
    • Q4VBP2
    • Q53XA2
    • Q6P2F6

    Protein attributes for PRH1 Gene

    Size:
    166 amino acids
    Molecular mass:
    17016 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI28193.1; Type=Erroneous termination; Positions=167; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAI41917.1; Type=Erroneous termination; Positions=167; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for PRH1 Gene

Post-translational modifications for PRH1 Gene

  • An hexuronic acid was shown to be linked to Ser-33 in about 40% of the polypeptides. Neither the structure of the carbohydrate (whether glucuronic acid or an isomer of), nor the linkage (whether a glycoside or an ester) has been definitely established.
  • Proteolytically cleaved; PRP-2, PRP-1, PIF-S and Db-S yield PRP-4, PRP-3 (protein A), PIF-F and Db-F, respectively.
  • Glycosylation at Ser33 and Ser38
  • Modification sites at PhosphoSitePlus

Other Protein References for PRH1 Gene

No data available for DME Specific Peptides for PRH1 Gene

Domains & Families for PRH1 Gene

Gene Families for PRH1 Gene

Protein Domains for PRH1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRH1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PRH1 Gene

Function for PRH1 Gene

Molecular function for PRH1 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,acidic,Hae III subfamily 1,see PR@ for references
UniProtKB/Swiss-Prot Function:
PRPs act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.

Gene Ontology (GO) - Molecular Function for PRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16203048
genes like me logo Genes that share ontologies with PRH1: view

Phenotypes for PRH1 Gene

genes like me logo Genes that share phenotypes with PRH1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRH1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRH1 Gene

Localization for PRH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRH1 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for PRH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 2993301
genes like me logo Genes that share ontologies with PRH1: view

Pathways & Interactions for PRH1 Gene

SuperPathway Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with PRH1: view

Pathways by source for PRH1 Gene

1 KEGG pathway for PRH1 Gene

Interacting Proteins for PRH1 Gene

Gene Ontology (GO) - Biological Process for PRH1 Gene

None

No data available for SIGNOR curated interactions for PRH1 Gene

Drugs & Compounds for PRH1 Gene

(1) Drugs for PRH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with PRH1: view

Transcripts for PRH1 Gene

Unigene Clusters for PRH1 Gene

Proline-rich protein HaeIII subfamily 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRH1

Alternative Splicing Database (ASD) splice patterns (SP) for PRH1 Gene

No ASD Table

Relevant External Links for PRH1 Gene

GeneLoc Exon Structure for
PRH1
ECgene alternative splicing isoforms for
PRH1

Expression for PRH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRH1 Gene

Protein differential expression in normal tissues from HIPED for PRH1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRH1 Gene



Protein tissue co-expression partners for PRH1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRH1 Gene:

PRH1

SOURCE GeneReport for Unigene cluster for PRH1 Gene:

Hs.656965

Evidence on tissue expression from TISSUES for PRH1 Gene

  • Saliva(4.3)
  • Thyroid gland(4)
genes like me logo Genes that share expression patterns with PRH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRH1 Gene

Orthologs for PRH1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRH1 35
  • 95 (a)
OneToOne
Species where no ortholog for PRH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRH1 Gene

ENSEMBL:
Gene Tree for PRH1 (if available)
TreeFam:
Gene Tree for PRH1 (if available)

Paralogs for PRH1 Gene

Paralogs for PRH1 Gene

(1) SIMAP similar genes for PRH1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PRH1: view

Variants for PRH1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRH1 Gene

PRPC_HUMAN-P02810
Sequence shown is that of allele PRH2-2, also known as PR-2; Allele PRH2-1 is also known as PR-1 or protein C, and allele PRH2-3 as PR-1. The PRH1-DB allele (about 16% of the population) has an insertion of 21 repeated amino acids compared to the more frequent PRH1-PIF allele (68%). In contrast to all other PRH1 and PRH2 alleles, the PRH1-PA allele (16%) is not proteolytically cleaved.

Sequence variations from dbSNP and Humsavar for PRH1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001066490 -- 11,098,681(+) CCAGA(C/T)TTGTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001080575 -- 11,098,615(+) TGTCT(A/G)AAGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1004515901 -- 11,098,183(+) AGCTG(A/G)CTTCA intron-variant, upstream-variant-2KB
rs1005731202 -- 11,098,942(+) TCCCA(C/T)TCAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1007989955 -- 11,098,270(+) TCTGC(C/T)GGGTC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRH1 Gene

Variant ID Type Subtype PubMed ID
dgv1375n100 CNV loss 25217958
dgv1376n100 CNV gain+loss 25217958
dgv1377n100 CNV gain 25217958
dgv1378n100 CNV loss 25217958
dgv172e201 CNV deletion 23290073
dgv173e201 CNV deletion 23290073
dgv174e201 CNV deletion 23290073
dgv2362n54 CNV loss 21841781
dgv2363n54 CNV gain 21841781
dgv2364n54 CNV gain+loss 21841781
dgv2365n54 CNV gain 21841781
dgv2366n54 CNV gain+loss 21841781
dgv2367n54 CNV loss 21841781
dgv2368n54 CNV loss 21841781
dgv2369n54 CNV gain 21841781
dgv2370n54 CNV gain+loss 21841781
dgv2371n54 CNV loss 21841781
dgv2372n54 CNV loss 21841781
dgv251e214 CNV loss 21293372
dgv265e199 CNV deletion 23128226
dgv266e199 CNV deletion 23128226
dgv267e199 CNV deletion 23128226
dgv268e199 CNV deletion 23128226
dgv271n67 CNV loss 20364138
dgv42e19 CNV loss 19470904
dgv43e19 CNV loss 19470904
dgv453e212 CNV gain 25503493
dgv454e212 CNV gain 25503493
dgv455e212 CNV loss 25503493
dgv456e212 CNV loss 25503493
dgv457e212 CNV gain 25503493
dgv458e212 CNV gain 25503493
dgv459e212 CNV loss 25503493
dgv768n106 CNV deletion 24896259
dgv769n106 CNV deletion 24896259
dgv770n106 CNV deletion 24896259
dgv771n106 CNV deletion 24896259
dgv79e215 CNV deletion 23714750
esv1010712 CNV deletion 20482838
esv1011370 CNV insertion 20482838
esv1361137 CNV deletion 17803354
esv23283 CNV loss 19812545
esv2421447 CNV deletion 20811451
esv2421542 CNV deletion 20811451
esv24685 CNV loss 19812545
esv2570297 CNV deletion 19546169
esv26197 CNV gain 19812545
esv2660326 CNV deletion 23128226
esv2661296 CNV deletion 23128226
esv2664609 CNV deletion 23128226
esv2665068 CNV deletion 23128226
esv2668043 CNV deletion 23128226
esv2670207 CNV deletion 23128226
esv2675860 CNV deletion 23128226
esv2745543 CNV deletion 23290073
esv2745544 CNV deletion 23290073
esv2745545 CNV deletion 23290073
esv2745546 CNV deletion 23290073
esv2745548 CNV deletion 23290073
esv2745549 CNV deletion 23290073
esv2745550 CNV deletion 23290073
esv2745553 CNV deletion 23290073
esv2745554 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv2760999 CNV gain+loss 21179565
esv2874902 CNV deletion 24192839
esv3159002 CNV deletion 24192839
esv3254051 CNV deletion 24192839
esv3306179 CNV mobile element insertion 20981092
esv3306327 CNV mobile element insertion 20981092
esv3309528 CNV mobile element insertion 20981092
esv3323418 CNV insertion 20981092
esv3328135 CNV insertion 20981092
esv33303 CNV gain 17666407
esv3361948 CNV duplication 20981092
esv3418271 CNV duplication 20981092
esv3419678 CNV insertion 20981092
esv3548756 CNV deletion 23714750
esv3548757 CNV deletion 23714750
esv3548758 CNV deletion 23714750
esv3580860 CNV gain 25503493
esv3628543 CNV gain 21293372
esv3628548 CNV loss 21293372
esv3628550 CNV loss 21293372
esv3628551 CNV loss 21293372
esv3628552 CNV loss 21293372
esv3628555 CNV gain 21293372
esv3628556 CNV loss 21293372
esv3628557 CNV loss 21293372
esv3628559 CNV loss 21293372
esv3628560 CNV gain 21293372
esv3628561 CNV loss 21293372
esv3628562 CNV gain 21293372
esv3628563 CNV loss 21293372
esv4169 CNV loss 18987735
esv5675 CNV loss 19470904
esv7358 CNV loss 19470904
esv8289 CNV loss 19470904
esv995298 CNV deletion 20482838
esv998570 CNV deletion 20482838
nsv1038277 CNV loss 25217958
nsv1038323 CNV loss 25217958
nsv1038709 CNV loss 25217958
nsv1050050 CNV loss 25217958
nsv1054664 CNV gain 25217958
nsv1068640 CNV deletion 25765185
nsv1069427 CNV deletion 25765185
nsv1070093 CNV deletion 25765185
nsv1070510 CNV deletion 25765185
nsv1070511 CNV deletion 25765185
nsv1070512 CNV deletion 25765185
nsv1071012 CNV deletion 25765185
nsv1112616 CNV deletion 24896259
nsv1113460 CNV deletion 24896259
nsv1113461 CNV deletion 24896259
nsv1113462 CNV deletion 24896259
nsv1116692 CNV tandem duplication 24896259
nsv1122698 CNV deletion 24896259
nsv1122699 CNV deletion 24896259
nsv1122700 CNV deletion 24896259
nsv1127248 CNV deletion 24896259
nsv1132355 CNV duplication 24896259
nsv1134198 CNV deletion 24896259
nsv1134199 CNV deletion 24896259
nsv1138101 CNV deletion 24896259
nsv1138102 CNV deletion 24896259
nsv1138104 CNV deletion 24896259
nsv1139564 CNV duplication 24896259
nsv1144607 CNV deletion 24896259
nsv1145582 CNV deletion 24896259
nsv1152020 CNV duplication 26484159
nsv1152044 CNV deletion 26484159
nsv1152771 CNV duplication 26484159
nsv1153140 CNV deletion 26484159
nsv1159978 CNV duplication 26073780
nsv1159979 CNV deletion 26073780
nsv428272 CNV gain+loss 18775914
nsv436149 CNV deletion 17901297
nsv442634 CNV loss 18776908
nsv471366 CNV gain 19718026
nsv511013 OTHER complex 20534489
nsv513355 CNV insertion 21212237
nsv514646 CNV gain+loss 21397061
nsv514647 CNV gain+loss 21397061
nsv516631 CNV loss 19592680
nsv52653 CNV deletion 16902084
nsv557482 CNV loss 21841781
nsv557486 CNV loss 21841781
nsv557487 CNV loss 21841781
nsv557488 CNV gain 21841781
nsv557489 CNV loss 21841781
nsv557497 CNV gain 21841781
nsv557501 CNV loss 21841781
nsv557522 CNV loss 21841781
nsv557525 CNV loss 21841781
nsv820968 CNV duplication 20802225
nsv826250 CNV loss 20364138
nsv832330 CNV gain 17160897
nsv8915 CNV gain 18304495
nsv8916 CNV gain 18304495
nsv8917 CNV loss 18304495
nsv951326 CNV duplication 24416366
nsv951327 CNV duplication 24416366
nsv957429 CNV deletion 24416366
nsv958654 CNV deletion 24416366
nsv958700 CNV deletion 24416366
nsv973026 CNV duplication 23825009
nsv973027 CNV duplication 23825009
nsv973028 CNV duplication 23825009
nsv975449 CNV duplication 23825009
nsv975450 CNV duplication 23825009
nsv976575 CNV duplication 23825009
nsv977132 CNV duplication 23825009
nsv983283 CNV duplication 23825009
nsv983284 CNV duplication 23825009
nsv983285 CNV duplication 23825009

Variation tolerance for PRH1 Gene

Gene Damage Index Score: 1.77; 33.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRH1

Disorders for PRH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRH1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dental caries
  • dental caries extending into pulp
- elite association - COSMIC cancer census association via MalaCards
Search PRH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRH1

Genetic Association Database (GAD)
PRH1
Human Genome Epidemiology (HuGE) Navigator
PRH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRH1
genes like me logo Genes that share disorders with PRH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRH1 Gene

Publications for PRH1 Gene

  1. Different isoforms and post-translational modifications of human salivary acidic proline-rich proteins. (PMID: 15693058) Inzitari R. … Messana I. (Proteomics 2005) 3 4 22 64
  2. Structures of two HaeIII-type genes in the human salivary proline- rich protein multigene family. (PMID: 3009472) Kim H.-S. … Maeda N. (J. Biol. Chem. 1986) 2 3 4 64
  3. A single kinase generates the majority of the secreted phosphoproteome. (PMID: 26091039) Tagliabracci V.S. … Dixon J.E. (Cell 2015) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Finding new posttranslational modifications in salivary proline-rich proteins. (PMID: 20879038) Vitorino R. … Amado F.L. (Proteomics 2010) 3 4 64

Products for PRH1 Gene

Sources for PRH1 Gene

Content
Loading form....