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PRG4 Gene

protein-coding   GIFtS: 59
GCID: GC01P186265

Proteoglycan 4

(Previous names: proteoglycan 4, (megakaryocyte stimulating factor, articular...)
(Previous symbol: CACP)
  See PRG4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteoglycan 41 2     HAPO2 5
CACP1 2 5     arthropathy1
MSF2 3 5     camptodactyly1
SZP2 3 5     Coxa Vara1
Articular Superficial Zone Protein1 2     Jacobs Camptodactyly-Arthropathy-Pericarditis Syndrome1
BG174L6.2 (MSF: Megakaryocyte Stimulating Factor )1 2     Pericarditis Syndrome1
lubricin1 2     Proteoglycan 4, (Megakaryocyte Stimulating Factor, Articular Superficial
Zone Protein, Camptodactyly, Arthropathy, Coxa Vara, Pericarditis
Syndrome)1
Megakaryocyte Stimulating Factor1 2     JCAP2
Megakaryocyte-Stimulating Factor2 3     bG174L6.22
Superficial Zone Proteoglycan2 3     Lubricin3

External Ids:    HGNC: 93641   Entrez Gene: 102162   Ensembl: ENSG000001166907   OMIM: 6042835   UniProtKB: Q929543   

Export aliases for PRG4 gene to outside databases

Previous GC identifers: GC01P183791 GC01P181693 GC01P182785 GC01P183504 GC01P182997 GC01P184532 GC01P157499


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRG4 Gene:
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the
surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin
sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and
contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in
camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRG4 Gene:
PRG4 (proteoglycan 4) is a protein-coding gene. Diseases associated with PRG4 include camptodactyly arthropathy coxa vara pericarditis syndrome, and pericarditis. GO annotations related to this gene include scavenger receptor activity and polysaccharide binding. An important paralog of this gene is VTN.

UniProtKB/Swiss-Prot: PRG4_HUMAN, Q92954
Function: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto
cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of
synovial cells to the cartilage surface
Function: Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and
endothelial cell lineages

Gene Wiki entry for PRG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRG4 gene promoter:
         TBP   Tal-1beta   LCR-F1   C/EBPalpha   PPAR-gamma1   POU2F1   POU2F1a   HFH-1   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRG4 promoter sequence
   Search Chromatin IP Primers for PRG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25-q31   Ensembl cytogenetic band:  1q31.1   HGNC cytogenetic band: 1q25-q31

PRG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRG4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P186265:  view genomic region     (about GC identifiers)

Start:
186,265,405 bp from pter      End:
186,283,694 bp from pter
Size:
18,290 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRG4_HUMAN, Q92954 (See protein sequence)
Recommended Name: Proteoglycan 4 precursor  
Size: 1404 amino acids; 151077 Da
Subunit: Homodimer; disulfide-linked (By similarity)
Miscellaneous: Different forms varying in molecular weight have been observed. Such forms are possibly due to
different levels of glycosylation and protein cleavage (By similarity)
Secondary accessions: Q6DNC4 Q6DNC5 Q6ZMZ5 Q9BX49
Alternative splicing: 6 isoforms:  Q92954-1   Q92954-2   Q92954-3   Q92954-4   Q92954-5   Q92954-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRG4: NX_Q92954

Explore proteomics data for PRG4 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • O-glycosylated; contains glycosaminoglycan chondroitin sulfate and keratan sulfate1
  • The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage (By similarity)1
  • Glycosylation2 at Asn206, Asn1159
  • Modification sites at PhosphoSitePlus

  • See PRG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001121180.1  NP_001121181.1  NP_001121182.1  NP_005798.2  

    ENSEMBL proteins: 
     ENSP00000431330   ENSP00000356452   ENSP00000356453   ENSP00000356455   ENSP00000399679  
     ENSP00000356456   ENSP00000356454  

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRG4

     
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    antibodies-online proteins for PRG4 

     
    antibodies-online peptides for PRG4

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    Cloud-Clone Corp. ELISAs for PRG4
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    antibodies-online kits for PRG4 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000585 Hemopexin-like_dom
     IPR018486 Hemopexin_CS
     IPR018487 Hemopexin-like_repeat
     IPR001212 Somatomedin_B_dom
     IPR020436 Somatomedin_B_chordata

    Graphical View of Domain Structure for InterPro Entry Q92954

    ProtoNet protein and cluster: Q92954

    1 Blocks protein domain: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: PRG4_HUMAN, Q92954
    Similarity: Contains 2 hemopexin repeats
    Similarity: Contains 2 SMB (somatomedin-B) domains


    Find genes that share domains with PRG4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRG4_HUMAN, Q92954
    Function: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto
    cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of
    synovial cells to the cartilage surface
    Function: Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and
    endothelial cell lineages

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity IEA--
    GO:0030247polysaccharide binding IEA--
         
    Find genes that share ontologies with PRG4           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prg4):
     behavior/neurological  cardiovascular system  limbs/digits/tail  mortality/aging  skeleton 

    Find genes that share phenotypes with PRG4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prg4tm1Mawa for PRG4

       genOway: Develop your customized and physiologically relevant rodent model for PRG4

    miRNA
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    miRTarBase miRNAs that target PRG4:
    hsa-mir-9-5p (MIRT021458)

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    hsa-miR-3163 hsa-miR-3662 hsa-miR-4282 hsa-miR-1257 hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmidPRG4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRG4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRG4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRG4_HUMAN, Q92954: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with PRG4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRG4 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRG4 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRG4
    Interactions:

        Search GeneGlobe Interaction Network for PRG4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for PRG4 (Q929542, 3 ENSP000003564524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    --P310162MINT-8108622
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0008283cell proliferation TAS10545950
    GO:0042127regulation of cell proliferation IEA--
    GO:0045409negative regulation of interleukin-6 biosynthetic process IEA--
    GO:0071425hematopoietic stem cell proliferation IEA--

    Find genes that share ontologies with PRG4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRG4

    6 Novoseek inferred chemical compound relationships for PRG4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyaluronic acid 61.6 25 18181652 (7), 19556078 (4), 9570073 (2), 11461663 (1) (see all 5)
    keratan sulfate 53.5 4 11518279 (1)
    alginate 30.8 3 17676563 (2)
    latex 29.2 2 12441670 (1), 10743795 (1)
    hydroxyapatite 22.6 4 16088901 (1), 16779825 (1)
    cisplatin 12.3 18 10545950 (6), 15702367 (4), 16429407 (2)



    Find genes that share compounds with PRG4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRG4 gene (4 alternative transcripts): 
    NM_001127708.1  NM_001127709.1  NM_001127710.1  NM_005807.3  

    Unigene Cluster for PRG4:

    Proteoglycan 4
    Hs.647723  [show with all ESTs]
    Unigene Representative Sequence: NM_005807
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533951 ENST00000367482 ENST00000367483(uc001grt.4 uc010poo.2)
    ENST00000367485 ENST00000445192(uc001gru.4) ENST00000367486(uc009wyl.3 uc009wym.3)
    ENST00000367484
    miRNA
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    hsa-miR-3163 hsa-miR-3662 hsa-miR-4282 hsa-miR-1257 hsa-miR-4280
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat PRG4

    Additional mRNA sequence: 

    AK057197.1 AK131434.1 AK297718.1 AK301343.1 AK301487.1 AK308235.1 U70136.1 

    7 DOTS entries:

    DT.99947504  DT.91758574  DT.100751817  DT.121407500  DT.448411  DT.100036341  DT.91874004 

    Selected AceView cDNA sequences (see all 62):

    BQ044944 BQ183014 AY653037 CR595257 CA447409 CA396776 CB270451 BP344692 
    CD252435 BG618358 BG926128 CB269032 AY653038 AK057197 AL555058 BX646781 
    H82331 NM_005807 CB162671 AA345199 AL694336 BX369690 AI925428 CA435357 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PRG4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                          
    SP2:                                                                                          
    SP3:        -                                                                                 
    SP4:        -           -                                                                     


    ECgene alternative splicing isoforms for PRG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTATACCAG
    PRG4 Expression
    About this image


    PRG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             Cartilage Cells Nasal Capsule
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Disc Cells Temporomandibular Joint
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Interzone Cells Stylopod Synovial Joint
             Zeugopod
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Mature Cardiac Fibroblasts Myocardium
    PRG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647723

    UniProtKB/Swiss-Prot: PRG4_HUMAN, Q92954
    Tissue specificity: Highly expressed in synovial tissue, cartilage and liver and weakly in heart and lung. Isoform
    B is expressed in kidney, lung, liver, heart and brain. Isoform C and isoform D are widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRG4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRG4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prg45 proteoglycan 4 (megakaryocyte stimulating factor, articular more   --   1 (63.84 cM) 150449816 
    chicken
    (Gallus gallus)
    Aves PRG46
    proteoglycan 4
    34(a)
    1 ↔ 1
    8(9975769-9981576)
    lizard
    (Anolis carolinensis)
    Reptilia PRG46
    proteoglycan 4
    29(a)
    1 ↔ 1
    GL343203.1(2499722-2541877)
    zebrafish
    (Danio rerio)
    Actinopterygii prg4a6
    prg4b6
    proteoglycan 4b
    33(a)
    32(a)
    many → 1
    many → 1
    2(20566497-20584574) ENSDARG00000010482
    20(34054428-34065203) ENSDARG00000028163


    ENSEMBL Gene Tree for PRG4 (if available)
    TreeFam Gene Tree for PRG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRG4 gene
    VTN2  ENSG000002731712  
    1 SIMAP similar gene for PRG4 using alignment to 4 protein entries:     PRG4_HUMAN (see all proteins):
    VTN

    Find genes that share paralogs with PRG4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRG4 (see all 477)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs66985941,2
    C,F--157498002(+) GTCTAC/TGTAGA 4 -- us2k11Minor allele frequency- T:0.17WA 118
    rs1932984901,2
    --157498071(+) TGGCTC/TGGGTT 4 -- us2k10--------
    rs66743221,2
    C,F,A--157498104(+) CTATCA/GGCTGT 4 -- us2k11Minor allele frequency- G:0.17WA 118
    rs1855159501,2
    --157498307(+) AGTCAC/GAATCT 4 -- us2k10--------
    rs1902745871,2
    --157498613(+) ACAGCA/GGAATC 4 -- us2k10--------
    rs1814461651,2
    --157498645(+) ACTGAA/GCATGT 4 -- us2k10--------
    rs1842351161,2
    --157498661(+) TTTTTA/TTCTTT 4 -- us2k10--------
    rs1458966411,2
    --157498675(+) TTTTTC/TTTTTT 4 -- us2k10--------
    rs618311461,2
    C,F--157498738(+) CAGCTT/CACTGC 4 -- us2k13Minor allele frequency- C:0.33NA 6
    rs1409426051,2
    --157498756(+) GCCTCC/TCAGGT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRG4 (186265405 - 186283694 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRG4: --
    Human Gene Mutation Database (HGMD): PRG4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRG4
    DNA2.0 Custom Variant and Variant Library Synthesis for PRG4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604283   
    OMIM disorders: 208250  
    UniProtKB/Swiss-Prot: PRG4_HUMAN, Q92954
  • Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) [MIM:208250]: Autosomal recessive
    disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint
    failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for PRG4:    
    About MalaCards
    camptodactyly arthropathy coxa vara pericarditis syndrome    pericarditis    arthropathy    myxoid liposarcoma

    5 diseases from the University of Copenhagen DISEASES database for PRG4:
    Gestational diabetes     Pericarditis     Hyperglycemia     Osteoarthritis
    Arthropathy

    Find genes that share disorders with PRG4           About GenesLikeMe

    6 Novoseek inferred disease relationships for PRG4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cacp syndrome 96 12 15702367 (3), 10545950 (2), 15719068 (1), 16000300 (1) (see all 5)
    osteoarthritis 62.6 6 10743795 (1), 11461663 (1), 17106881 (1), 17343281 (1)
    synovitis 42 1 15702367 (1)
    rheumatoid arthritis 28 5 15142643 (2), 11461663 (1)
    inflammation 0 3 9920774 (1), 12475643 (1)
    tumors 0 3 17373642 (1), 18512776 (1)

    Genetic Association Database (GAD): PRG4
    Human Genome Epidemiology (HuGE) Navigator: PRG4 (2 documents)

    Export disorders for PRG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRG4 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with PRG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. (PubMed id 9920774)1, 2, 3, 9 Flannery C.R.... Caterson B. (Biochem. Biophys. Res. Commun. 1999)
    2. CACP, encoding a secreted proteoglycan, is mutated in camptodactyly- arthropathy-coxa vara-pericarditis syndrome. (PubMed id 10545950)1, 2, 3, 9 Marcelino J.... Warman M.L. (Nat. Genet. 1999)
    3. Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts. (PubMed id 10743795)1, 2, 9 Jay G.D.... Cha C.-J. (J. Rheumatol. 2000)
    4. Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. (PubMed id 11124536)1, 2, 9 Ikegawa S.... Nakamura Y. (Cytogenet. Cell Genet. 2000)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. (PubMed id 14976050)1, 2 Liu Y.J.... Han Z.C. (Blood 2004)
    10. A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage. (PubMed id 8185311)1, 2 Schumacher B.L....Kuettner K.E. (Arch. Biochem. Biophys. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10216 HGNC: 9364 AceView: PRG4 Ensembl:ENSG00000116690 euGenes: HUgn10216
    ECgene: PRG4 H-InvDB: PRG4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRG4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRG4 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PRG4[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRG4 gene:
    Search GeneIP for patents involving PRG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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