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Aliases for PRG2 Gene

Aliases for PRG2 Gene

  • Proteoglycan 2, Pro Eosinophil Major Basic Protein 2 3 5
  • Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein) 2 3
  • Eosinophil Major Basic Protein 2 3
  • BMPG 3 4
  • MBP 3 4
  • Eosinophil Granule Major Basic Protein 3
  • Natural Killer Cell Activator 3
  • Proteoglycan 2 Preproprotein 3
  • Bone Marrow Proteoglycan 3
  • Proteoglycan 2 4
  • ProMBP 3
  • MBP1 3

External Ids for PRG2 Gene

Previous GeneCards Identifiers for PRG2 Gene

  • GC11M059548
  • GC11M058668
  • GC11M057405
  • GC11M056930
  • GC11M056911
  • GC19M000764
  • GC11M057154
  • GC11M053504

Summaries for PRG2 Gene

Entrez Gene Summary for PRG2 Gene

  • The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for PRG2 Gene

PRG2 (Proteoglycan 2, Pro Eosinophil Major Basic Protein) is a Protein Coding gene. Diseases associated with PRG2 include Eosinophilic Colitis and Hypereosinophilic Syndrome. Among its related pathways are Phospholipase-C Pathway and Innate Immune System. GO annotations related to this gene include carbohydrate binding and heparin binding. An important paralog of this gene is PRG3.

UniProtKB/Swiss-Prot for PRG2 Gene

  • Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Wiki entry for PRG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRG2 Gene

Genomics for PRG2 Gene

Regulatory Elements for PRG2 Gene

Enhancers for PRG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G057357 1 ENCODE 20.8 +31.5 31492 2.8 ATF1 PKNOX1 ARNT TCF12 ZNF766 GATA2 FOS NCOA1 REST ZNF592 PRG2 P2RX3 ENSG00000254979 SLC43A3 SSRP1 RN7SKP259 RTN4RL2 ENSG00000254662 TNKS1BP1 SLC43A1
GH11G057405 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -16.1 -16110 2.4 PKNOX1 GATA2 FOS RELB ETV6 IKZF2 CREM JUNB GATAD2B REST SLC43A3 P2RX3 RN7SKP259 RTN4RL2 SSRP1 PRG2 TIMM10 UBE2L6 ZDHHC5 GC11M057408
GH11G057423 1.3 ENCODE dbSUPER 9.3 -35.4 -35445 4.9 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 SIN3A YY1 ZNF766 FOS KLF13 TIMM10 PRG2 RTN4RL2 SMTNL1 APLNR SLC43A3 ENSG00000254979
GH11G057368 0.5 ENCODE 21.6 +22.0 21955 0.2 IKZF1 HMBOX1 NFE2 ZEB2 SPI1 PRG2 ENSG00000254979 SLC43A3 SSRP1 P2RX3 RN7SKP259 RTN4RL2 TNKS1BP1 ENSG00000254662 TIMM10
GH11G057529 1.1 ENCODE 9.6 -140.0 -140033 2.5 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MIR130A UBE2L6 RPS4XP13 ENSG00000254602 CLP1 YPEL4 P2RX3 SSRP1 RTN4RL2 RN7SKP259
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRG2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PRG2 gene promoter:

Genomic Location for PRG2 Gene

Chromosome:
11
Start:
57,386,787 bp from pter
End:
57,390,657 bp from pter
Size:
3,871 bases
Orientation:
Minus strand

Genomic View for PRG2 Gene

Genes around PRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRG2 Gene

Proteins for PRG2 Gene

  • Protein details for PRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13727-PRG2_HUMAN
    Recommended name:
    Bone marrow proteoglycan
    Protein Accession:
    P13727
    Secondary Accessions:
    • A6XMW0
    • B2R5I1
    • P81448
    • Q14227
    • Q6ICT2

    Protein attributes for PRG2 Gene

    Size:
    222 amino acids
    Molecular mass:
    25206 Da
    Quaternary structure:
    • In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
    Miscellaneous:
    • Binds heparin. Does not bind calcium.

    Three dimensional structures from OCA and Proteopedia for PRG2 Gene

    Alternative splice isoforms for PRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRG2 Gene

Post-translational modifications for PRG2 Gene

  • Nitrated.
  • Glycosylation at Thr23, Ser24, posLast=2525, posLast=3434, Ser62, and posLast=8686
  • Modification sites at PhosphoSitePlus

Other Protein References for PRG2 Gene

Antibody Products

  • Abcam antibodies for PRG2

No data available for DME Specific Peptides for PRG2 Gene

Domains & Families for PRG2 Gene

Gene Families for PRG2 Gene

Suggested Antigen Peptide Sequences for PRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRG2: view

No data available for UniProtKB/Swiss-Prot for PRG2 Gene

Function for PRG2 Gene

Molecular function for PRG2 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Ontology (GO) - Molecular Function for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA --
GO:0030246 carbohydrate binding IEA,TAS --
genes like me logo Genes that share ontologies with PRG2: view
genes like me logo Genes that share phenotypes with PRG2: view

Animal Models for PRG2 Gene

MGI Knock Outs for PRG2:

Animal Model Products

CRISPR Products

miRNA for PRG2 Gene

miRTarBase miRNAs that target PRG2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRG2 Gene

Localization for PRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRG2 Gene

Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophils large specific granule (crystalloid core).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRG2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with PRG2: view

Pathways & Interactions for PRG2 Gene

genes like me logo Genes that share pathways with PRG2: view

Pathways by source for PRG2 Gene

3 Reactome pathways for PRG2 Gene
1 KEGG pathway for PRG2 Gene

Gene Ontology (GO) - Biological Process for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode IEA --
GO:0002376 immune system process IEA --
GO:0006955 immune response IEA --
GO:0032693 negative regulation of interleukin-10 production IEA --
GO:0032753 positive regulation of interleukin-4 production IEA --
genes like me logo Genes that share ontologies with PRG2: view

No data available for SIGNOR curated interactions for PRG2 Gene

Drugs & Compounds for PRG2 Gene

(26) Drugs for PRG2 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sargramostim Approved, Investigational Pharma Target 0
Leukine Approved on November 24, 1995/ Approved November 1996 Pharma 0
calcium Nutra 0

(18) Additional Compounds for PRG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRG2: view

Transcripts for PRG2 Gene

Unigene Clusters for PRG2 Gene

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for PRG2 Gene

GeneLoc Exon Structure for
PRG2
ECgene alternative splicing isoforms for
PRG2

Expression for PRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRG2 Gene

This gene is overexpressed in Whole Blood (x31.2).

Protein differential expression in normal tissues from HIPED for PRG2 Gene

This gene is overexpressed in Neutrophil (46.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRG2 Gene



Protein tissue co-expression partners for PRG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRG2 Gene:

PRG2

SOURCE GeneReport for Unigene cluster for PRG2 Gene:

Hs.512633

mRNA Expression by UniProt/SwissProt for PRG2 Gene:

P13727-PRG2_HUMAN
Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.

Evidence on tissue expression from TISSUES for PRG2 Gene

  • Bone marrow(4.5)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PRG2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRG2 Gene

Orthologs for PRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRG2 34
  • 99.1 (n)
-- 35
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prg2 34
  • 68.47 (n)
mouse
(Mus musculus)
Mammalia Prg2 34 16 35
  • 67.72 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 33 (a)
OneToMany
Species where no ortholog for PRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRG2 Gene

ENSEMBL:
Gene Tree for PRG2 (if available)
TreeFam:
Gene Tree for PRG2 (if available)

Paralogs for PRG2 Gene

Paralogs for PRG2 Gene

(2) SIMAP similar genes for PRG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRG2: view

Variants for PRG2 Gene

Sequence variations from dbSNP and Humsavar for PRG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs142359007 A colorectal cancer sample 57,387,829(+) CCAGC(A/G)GCTGC reference, missense
rs1000878535 -- 57,387,723(+) AGACC(C/T)TTCCA intron-variant
rs1002892513 -- 57,390,110(+) CCCAG(C/T)TCCTG intron-variant
rs1003107304 -- 57,391,750(+) CCAAC(C/G)TACCA upstream-variant-2KB
rs1003174975 -- 57,391,273(+) GTATT(C/T)AGTAT upstream-variant-2KB

Variation tolerance for PRG2 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRG2 Gene

Disorders for PRG2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for PRG2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
eosinophilic colitis
hypereosinophilic syndrome
  • hypereosinophilic syndrome, idiopathic
atopic keratoconjunctivitis
vitreous syneresis
  • vitreous degeneration
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search PRG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRG2

Human Genome Epidemiology (HuGE) Navigator
PRG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRG2
genes like me logo Genes that share disorders with PRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRG2 Gene

Publications for PRG2 Gene

  1. Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PMID: 1565101) Yoshimatsu K. … Osawa T. (Mol. Immunol. 1992) 2 3 4 22 64
  2. Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity. (PMID: 11319227) Swaminathan G.J. … Acharya K.R. (J. Biol. Chem. 2001) 3 4 22 64
  3. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PMID: 7531438) Li M.S. … Spry C.J. (Biochem. J. 1995) 3 4 22 64
  4. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PMID: 7526035) Bonno M. … Gleich G.J. (Lab. Invest. 1994) 3 4 22 64
  5. Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. (PMID: 2323577) Barker R.L. … Gleich G.J. (Gene 1990) 3 4 22 64

Products for PRG2 Gene

Sources for PRG2 Gene

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