V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PRG2 Gene

protein-coding GIFtS: 60

GC11M056911

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BMPG ^¹, ², ³
MBP ^¹, ², ³, ⁵
MBP1 ^²
MGC14537 ^²

Descriptions
Proteoglycan 2 ^², ³
bone-marrow proteoglycan ^²
eosinophil granule major basic protein ^²
eosinophil major basic protein ^²
natural killer cell activator ^²
proteoglycan 2 preproprotein ^²
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) ^²

External Ids
HGNC: 9362¹
Entrez Gene: 5553²
UniProtKB: P13727³
Ensembl: ENSG00000186652⁷

Search outside databases for aliases for PRG2 gene

Previous GC identifers: GC11M059548 GC11M058668 GC11M057405 GC11M056930 GC19M000764

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PRG2:

The protein encoded by this gene is the predominant constituent of the crystalline core of the

eosinophil granule. High levels of the proform of this protein are also present in placenta and

pregnancy serum, where it exists as a complex with several other proteins including

pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may

be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune

hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and

bronchospasm in allergic diseases. [provided by RefSeq]

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human

basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The

proform acts as a proteinase inhibitor, reducing the activity of PAPPA

Gene Wiki entry for PRG2 (Major_basic_protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PRG2 gene

Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12

PRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M056911: (about GC identifiers)

Start:	56,910,843 bp from pter
End:	56,914,706 bp from pter
Size:	3,864 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727 (See protein sequence)

Recommended Name: Bone marrow proteoglycan precursor

Size: 222 amino acids; 25232 Da

Subunit: In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with

PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2

heterohexamer) with AGT and C3dg

Subcellular location: Note=The proform is secreted. The mature protein is found in the matrix of

the eosinophil's large specific granule (crystalloid core)

Developmental stage: Levels of the proform increase in serum and placenta during pregnancy

Miscellaneous: Binds heparin. Does not bind calcium

PDB structure from and Proteopedia :

1H8U (3D)

2BRS (3D)

Secondary accessions: P81448 Q14227 Q6ICT2

REFSEQ proteins: NP_002719.3

ENSEMBL proteins:

ENSP00000312134

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PRG2)
	Human Recombinant Proteins from Abnova (PRG2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	8547309

About this table

Antibodies for PRG2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PRG2
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PRG2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PRG2)
	Novus Biologicals Antibody for PRG2

Assays for PRG2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13727

ProtoNet protein and cluster: P13727

1 Blocks protein family: IPB002352 Eosinophil major basic protein signature

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Similarity: Contains 1 C-type lectin domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PRG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PRG2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002728

Applied Biosystems Silencer® siRNAs for PRG2

Sigma-Aldrich siRNA and siRNA Panels for PRG2

Sigma-Aldrich shRNA Panels and shRNA for PRG2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002728
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002728
untagged cDNA clone in CMV expression vector: NM_002728

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002728

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human

basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The

proform acts as a proteinase inhibitor, reducing the activity of PAPPA

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--
GO:0005529	sugar binding	TAS	1565101
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PRG2

4 Interacting proteins for PRG2 (ENSP00000312134³ P13727²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHD3	Q12873²	MINT-63471
PAPPAS	ENSP00000330658³	STRING (score=.976)
VCAN	ENSP00000265077³	STRING (score=.901)
--	Q9P078²	MINT-63470

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0042742	defense response to bacterium	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PRG2
10/25 Novoseek chemical compound relationships for PRG2 gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
estromustine	91.13	9	9748122 (2), 1888147 (2), 1626200 (1), 7638085 (1) (see all 6)
maltose	50.85	8	9782274 (1), 19177560 (1), 15097997 (1), 16442308 (1) (see all 6)
amylose	47.49	1	10071937 (1)
phosphatidyl ethanol	43.19	1	8541554 (1)
cytochalasin	37.41	2	8541554 (1), 2170521 (1)
allergens	35.46	3	10536888 (1), 12197429 (1)
chromium	33.15	5	10224465 (1), 8541554 (1), 10485250 (1), 1295362 (1) (see all 5)
melittin	28.39	2	10224465 (1), 10485250 (1)
ltc4	26.74	1	2183575 (1)
hematoxylin	21.87	3	16900805 (1), 8221258 (1), 16556666 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PRG2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PRG2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002728

Sigma-Aldrich siRNA and siRNA Panels for PRG2

Sigma-Aldrich shRNA Panels and shRNA for PRG2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002728

REFSEQ mRNAs for PRG2 gene:

NM_002728.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002728

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002728
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002728
                                 untagged cDNA clone in CMV expression vector: NM_002728

Additional cDNA sequence:

AK312195.1 BC005929.1 CR450311.1 CR590212.1 CR590243.1 CR590778.1 CR591196.1 CR591375.1

CR591600.1 CR592750.1 CR593258.1 CR593804.1 CR593939.1 CR596367.1 CR597111.1 CR597334.1

CR598644.1 CR599398.1 CR599756.1 CR599931.1 CR600046.1 CR600307.1 CR600406.1 CR600722.1

CR601470.1 CR602064.1 CR602195.1 CR603205.1 CR603318.1 CR603683.1 CR604416.1 CR604651.1

CR604781.1 CR605665.1 CR605751.1 CR605780.1 CR605831.1 CR606081.1 CR606108.1 CR606261.1

CR606728.1 CR607616.1 CR607791.1 CR607959.1 CR608024.1 CR609247.1 CR609762.1 CR610280.1

CR610568.1 CR610865.1 CR611197.1 CR612910.1 CR613833.1 CR614707.1 CR615315.1 CR615431.1

CR615951.1 CR616445.1 CR617394.1 CR617406.1 CR617968.1 CR618388.1 CR618883.1 CR619331.1

CR619837.1 CR619867.1 CR619994.1 CR620046.1 CR620305.1 CR620478.1 CR621197.1 CR621593.1

CR622244.1 CR622493.1 CR622766.1 CR623831.1 CR624403.1 CR624461.1 CR624696.1 CR624849.1

CR625293.1 CR625586.1 CR625670.1 CR625915.1 CR626156.1 CR626455.1 CR626835.1 DQ846874.1

M35670.1 M36805.1 X14088.1 X65787.1 Y00809.1

17 DOTS entries:

DT.454353 DT.100697575 DT.100697567 DT.100697574 DT.95304053 DT.100719032 DT.100842776 DT.120728609

DT.100697579 DT.120728623 DT.91771600 DT.100697572 DT.100851914 DT.86854586 DT.91771603 DT.91771610

DT.95233827

24/873 AceView cDNA sequences (see all 873 ):

CR599756 CR610280 AA369033 CR603205 CR600046 CR602195 AA286984 CR618388

CR622244 CR603318 CR605780 BU628614 CR604781 CR624849 CF127273 CR619837

CR620305 AU137369 CR624403 CR599931 CR617968 BE877163 CR617406 CR609247

highest scoring ESTs for PRG2:

AA369036 AA369398 AA369532 AA369644 AL540626 AL540731 AL540750 AL540853 AL544843 AL549375

Unigene Cluster for PRG2:

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Hs.512633 [show with all ESTs]

Unigene Representative Sequence: CR621593

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PRG2

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7
SP1:
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for PRG2

1 Ensembl transcript including schematic representation:

ENST00000311862

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PRG2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PRG2

¹ / ² / ³

4 probe-sets matching PRG2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47857_at²^{, 3}	U95-B	1	1.00	1.00	0.94	0.79	AA149576	0.60	0.83	0.73	1
39179_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.22	Z26248	0.60	0.83	0.73	1
211743_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005929	0.80	0.88	0.84	1
211743_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PRG2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCCAAGGCTC

SOURCE GeneReport for Unigene cluster: Hs.512633
Expression variation in blood from EXPOLDB for PRG2
UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727
Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta,
localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues
including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PRG2 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Prg2¹	--	proteoglycan 2, bone marrow	70.78(n) 59.36(a)	58826 NM_031619.1 NP_113807.1
mouse (Mus musculus)	BC005764⁵ Prg2¹	10⁵	cDNA sequence BC005764⁵ proteoglycan 2, bone marrow¹	71.23(n)¹ 61.19(a)¹	19074¹ NM_008920.3¹ NP_032946.1¹ AF541278⁵ AI429690⁵ (see all 13)

About this table Species with no ortholog for PRG2

ENSEMBL Gene Tree for PRG2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PRG2 gene

PRG3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/42 NCBI SNPs in PRG2 are shown (see all 42 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 62)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs548854^1,2	A,C,F,H,O	56915765(-)	`AGGAAA/GGAAGT`	1	--	ng3¹ trp³		14		EU EA WA NA	1204
	rs7121288^1,2	A,C,F,H	56915595(+)	`aaaaaT/Catgca`	1	--	ng3¹		12		EU EA WA NA	1052
	rs7946828^1,2	A,C,F,H	56916439(+)	`CTCTTA/TACTCA`	1	--	ng3¹		4		EU EA WA	394
	rs7106575^1,2	A,C,F,H	56915003(+)	`CAAACA/GTTTTG`	1	--	ng3¹		7		EU EA WA NA	558
	rs536455^1,2	A,C,F,H	56911577(+)	`CCAGTA/GGCCTC`	1	H/Y	mis¹ ese³		13		MN EU EA WA NA	1214
	rs536352^1,2	A,C,F	56911106(+)	`AGAGAC/GAGAGA`	1	--	ng5¹ trp³		1		MN	184
	rs576531^1,2	A,C,H	56916494(+)	`gtactC/Taataa`	1	--	ng3¹		4		EU EA WA	406
	rs650455^1,2	F,H	56916214(-)	`TACCTC/TACTAG`	1	--	ng3¹		4		EU EA WA	414
	rs519628^1,2	F,H	56914896(+)	`GAACAG/ACTCTG`	1	--	ng3¹		4		EU EA WA	420
--	rs1151051^1,2	A,C	56916119(+)	`ttgggC/Tgagag`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for PRG2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605601

10/38 Novoseek disease relationships for PRG2 gene (see all 38 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
eosinophilia	68.17	12	8043431 (4), 7669668 (2), 2217619 (1), 19139036 (1) (see all 7)
hypereosinophilic syndrome	66.14	2	8043431 (1), 14988154 (1)
dermographism	58.00	2	8547035 (1)
asthma	49.63	35	16982448 (6), 8007454 (2), 1953909 (2), 2178530 (2) (see all 12)
nasal polyps	48.10	7	2178530 (2), 11112892 (2), 18476621 (1), 1688635 (1)
chronic sinusitis	47.50	2	18476621 (1), 2178530 (1)
dermatitis atopic	45.79	14	10749555 (4), 9558841 (4), 1937874 (1), 12197429 (1)
prostate carcinoma	43.80	16	8653325 (2), 8821700 (1), 8030169 (1), 7638085 (1) (see all 6)
pulmonary eosinophilia	39.75	1	2010556 (1)
allergy	39.38	6	10743163 (1), 8492464 (1), 9071212 (1), 2370389 (1) (see all 5)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/220 PubMed articles for PRG2 gene (see all 220 ):

Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PubMed id 1565101)^{1, 2, 3, 4} Yoshimatsu K.... Osawa T. (1992)
Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PubMed id 7531438)^{1, 3, 4} Li M.S.... Spry C.J. (1995)
Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PubMed id 7526035)^{1, 3, 4} Bonno M.... Gleich G.J. (1994)
Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity. (PubMed id 11319227)^{1, 3, 4} Swaminathan G.J.... Acharya K.R. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites. (PubMed id 12421832)^{3, 4} Overgaard M.T.... Oxvig C. (2003)
Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. (PubMed id 10913121)^{3, 4} Overgaard M.T....Oxvig C. (2000)
Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. (PubMed id 10491647)^{3, 4} Overgaard M.T.... Haaning J. (1999)
Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. (PubMed id 7539791)^{3, 4} Oxvig C.... Sottrup-Jensen L. (1995)
Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA. (PubMed id 7508748)^{3, 4} Kristensen T.... Sottrup-Jensen L. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5553	HGNC: 9362	AceView: PRG2andSLC43A3	Ensembl:ENSG00000186652	euGenes: HUgn5553
ECgene: PRG2	H-InvDB: PRG2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PRG2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Major_basic_protein
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_207

Licensable Technologies for PRG2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PRG2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PRG2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PRG2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PRG2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PRG2)
	Antibodies (PRG2)
	Chimera RNAi (PRG2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PRG2)
	Antibodies (PRG2)

Search OriGene for PRG2

Search Tocris compounds for PRG2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PRG2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PRG2 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

PRG2 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for PRG2

Summaries
for PRG2

Genomic Location
for PRG2

Proteins
for PRG2

Protein Domains/
Families
for PRG2

Gene Function
for PRG2

Pathways & Interactions
for PRG2

Drugs & Compounds
for PRG2

Transcripts
for PRG2

Expression
for PRG2

Orthologs
for PRG2

Paralogs
for PRG2

SNPs/Variants
for PRG2

Disorders & Mutations
for PRG2

Medical News
for PRG2

Publications
for PRG2

Search for PRG2

Genome Databases showing PRG2

Other Databases showing PRG2

Specialized Databases showing PRG2

Licensable Technologies
for PRG2

Services
for PRG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PRG2 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor PRG2

Summariesfor PRG2

Genomic Locationfor PRG2

Proteinsfor PRG2

Protein Domains/Familiesfor PRG2

Gene Functionfor PRG2

Pathways & Interactionsfor PRG2

Drugs & Compoundsfor PRG2

Transcriptsfor PRG2

Expression for PRG2

Orthologsfor PRG2

Paralogsfor PRG2

SNPs/Variantsfor PRG2

Disorders & Mutationsfor PRG2

Medical Newsfor PRG2

Publicationsfor PRG2

Search for PRG2

Genome Databases showing PRG2

Other Databases showing PRG2

Specialized Databases showing PRG2

Licensable Technologiesfor PRG2

Servicesfor PRG2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PRG2

Summaries
for PRG2

Genomic Location
for PRG2

Proteins
for PRG2

Protein Domains/
Families
for PRG2

Gene Function
for PRG2

Pathways & Interactions
for PRG2

Drugs & Compounds
for PRG2

Transcripts
for PRG2

Expression
for PRG2

Orthologs
for PRG2

Paralogs
for PRG2

SNPs/Variants
for PRG2

Disorders & Mutations
for PRG2

Medical News
for PRG2

Publications
for PRG2

Licensable Technologies
for PRG2

Services
for PRG2