Aliases for PRG2 Gene
External Ids for PRG2 Gene
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
GeneCards Summary for PRG2 Gene
PRG2 (Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein)) is a Protein Coding gene. Diseases associated with PRG2 include corneal opacification and other ocular anomalies and giant papillary conjunctivitis. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include carbohydrate binding and heparin binding. An important paralog of this gene is ENSG00000254979.
UniProtKB/Swiss-Prot for PRG2 Gene
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.