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PRG2 Gene

protein-coding   GIFtS: 62
GCID: GC11M057154

Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator,...

  See PRG2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil
Granule Major Basic Protein)1 2
     Eosinophil Granule Major Basic Protein2
MBP2 3 5     Eosinophil Major Basic Protein2
BMPG2 3     Natural Killer Cell Activator2
MBP12     Proteoglycan 2 Preproprotein2
Bone Marrow Proteoglycan2     Proteoglycan 23
Bone-Marrow Proteoglycan2     

External Ids:    HGNC: 93621   Entrez Gene: 55532   Ensembl: ENSG000001866527   OMIM: 6056015   UniProtKB: P137273   

Export aliases for PRG2 gene to outside databases

Previous GC identifers: GC11M059548 GC11M058668 GC11M057405 GC11M056930 GC11M056911 GC19M000764 GC11M053504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRG2 Gene:
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule.
High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a
complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen
(AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and
helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage,
exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for PRG2 Gene:
PRG2 (proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)) is a protein-coding gene. Diseases associated with PRG2 include papillary conjunctivitis, and giant papillary conjunctivitis. GO annotations related to this gene include carbohydrate binding and heparin binding. An important paralog of this gene is ENSG00000254979.

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727
Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils.
Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a
proteinase inhibitor, reducing the activity of PAPPA

Gene Wiki entry for PRG2 (Major basic protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRG2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRG2 promoter sequence
   Search Chromatin IP Primers for PRG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

PRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRG2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057154:  view genomic region     (about GC identifiers)

Start:
57,154,267 bp from pter      End:
57,158,130 bp from pter
Size:
3,864 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727 (See protein sequence)
Recommended Name: Bone marrow proteoglycan precursor  
Size: 222 amino acids; 25206 Da
Subunit: In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a
disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg
Developmental stage: Levels of the proform increase in serum and placenta during pregnancy
Miscellaneous: Binds heparin. Does not bind calcium
2 PDB 3D structures from and Proteopedia for PRG2:
1H8U (3D)        2BRS (3D)    
Secondary accessions: P81448 Q14227 Q6ICT2

Explore the universe of human proteins at neXtProt for PRG2: NX_P13727

Explore proteomics data for PRG2 at MOPED

Post-translational modifications: 

  • Nitrated1
  • Glycosylation2 at Thr23, Ser24, Thr25, Thr34, Ser62, Asn86
  • Modification sites at PhosphoSitePlus

  • See PRG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230174.1  NP_002719.3  

    ENSEMBL proteins: 
     ENSP00000312134   ENSP00000433231   ENSP00000433016  

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for PRG2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR002352 Eosinophil_major_basic
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry P13727

    ProtoNet protein and cluster: P13727

    1 Blocks protein domain: IPB002352 Eosinophil major basic protein signature

    UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with PRG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRG2_HUMAN, P13727
    Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils.
    Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a
    proteinase inhibitor, reducing the activity of PAPPA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008201heparin binding IEA--
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with PRG2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRG2:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prg2):
     hematopoietic system  immune system  respiratory system 

    Find genes that share phenotypes with PRG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prg2tm1Nal for PRG2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRG2
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    hsa-miR-1827
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRG2_HUMAN, P13727: Bone marrow proteoglycan: Secreted. Note=The proform is secreted
    PRG2_HUMAN, P13727: Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The
    proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule
    (crystalloid core)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030133transport vesicle IEA--

    Find genes that share ontologies with PRG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56
    4Allograft rejection
    Asthma0.46
    5Selected targets of C EBPbeta
    Selected targets of C EBPbeta


    Find genes that share SuperPaths with PRG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PRG2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    1 Kegg Pathway  (Kegg details for PRG2):
        Asthma

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRG2: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for PRG2 (P137272, 3 ENSP000003121344) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHD3Q128732, 3MINT-63471 I2D: score=5 
    PAPPAQ132193, ENSP000003306584I2D: score=2 STRING: ENSP00000330658
    PRKCZQ055133, ENSP000003678304I2D: score=2 STRING: ENSP00000367830
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    CSF2P041413, ENSP000002968714I2D: score=2 STRING: ENSP00000296871
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0042742defense response to bacterium IEA--

    Find genes that share ontologies with PRG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for PRG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PLP (139-151)Encephalitogenic myelin proteolipid fragment[122018-58-0]
    ONO 2506Inhibits S100B synthesis; neuroprotective[185517-21-9]
    C3bot (154-182)Neurotrophic fragment of clostridial C3 protein[1246280-79-4]
    MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
    Nogo-66 (1-40)Competitive antagonist for Nogo-66 receptor; promotes neuron regeneration[475221-20-6]

    1 HMDB Compound for PRG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for PRG2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SargramostimColony-stimulating factor (see all 5)83869-56-1target--17383764 17600316 16522458

    Selected Novoseek inferred chemical compound relationships for PRG2 gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estromustine 91.1 9 9748122 (2), 1888147 (2), 1626200 (1), 7638085 (1) (see all 6)
    estracyt 86.3 4 7638085 (2), 1888147 (1), 1626200 (1)
    estramustine 86.3 38 9748122 (4), 7520576 (2), 8712706 (2), 8827085 (2) (see all 19)
    estramustine phosphate 76.6 4 1626200 (1), 7638085 (1), 8827085 (1), 7714550 (1)
    maltose 52.9 9 9782274 (1), 19177560 (1), 15097997 (1), 16442308 (1) (see all 7)
    histamine 50.2 24 10743163 (5), 7543541 (3), 7514197 (3), 8757629 (2) (see all 10)
    amylose 46.2 1 10071937 (1)
    phosphatidyl ethanol 42.4 1 8541554 (1)
    cytochalasin 37 2 8541554 (1), 2170521 (1)
    methacholine 36.2 5 8466137 (2), 2010556 (1), 8385431 (1), 8368165 (1)



    Find genes that share compounds with PRG2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRG2 gene (2 alternative transcripts): 
    NM_001243245.1  NM_002728.4  

    Unigene Cluster for PRG2:

    Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
    Hs.512633  [show with all ESTs]
    Unigene Representative Sequence: BX335104
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311862(uc001nkc.3 uc001nkd.3) ENST00000533605 ENST00000525955
    ENST00000530105
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK312195.1 BC005929.1 CR450311.1 DQ846874.1 M35670.1 M36805.1 X14088.1 X65787.1 
    Y00809.1 

    17 DOTS entries:

    DT.454353  DT.100697575  DT.100697567  DT.100719032  DT.95304053  DT.100697574  DT.100842776  DT.120728609 
    DT.100697579  DT.120728623  DT.91771600  DT.100697572  DT.100851914  DT.86854586  DT.91771603  DT.91771610 
    DT.95233827 

    Selected AceView cDNA sequences (see all 873):

    CR596367 BC064137 CR590212 BQ723184 CR622493 CR620046 CR625586 CR622244 
    BQ894821 CR626455 BM915372 AA369033 CR612910 CR621593 CR606081 CR604416 
    T48611 CA310160 CR597111 AA284125 CB159935 AI074500 CR607959 BG034553 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PRG2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for PRG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTCCCCTC
    PRG2 Expression
    About this image


    PRG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Liver (Hepatobiliary System)
    PRG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512633

    UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727
    Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells
    of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium,
    endometrium, ovaries, breast, prostate, bone marrow and colon

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRG2: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRG2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prg21 , 5 proteoglycan 2, bone marrow1, 5 67.72(n)1
    56.31(a)1
      2 (49.45 cM)5
    190741  NM_008920.41  NP_032946.11 
     849804615 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    33(a)
    1 → many
    5(16325506-16327147) ENSGALG00000007420


    ENSEMBL Gene Tree for PRG2 (if available)
    TreeFam Gene Tree for PRG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRG2 gene
    ENSG000002549792  PRG32  
    2 SIMAP similar genes for PRG2 using alignment to 2 protein entries:     PRG2_HUMAN (see all proteins):
    PRG3    SLED1

    Find genes that share paralogs with PRG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRG2 (see all 191)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364014
    A colorectal cancer sample4--see VAR_0364012 R C mis40--------
    rs799742751,2
    C,F--57154430(+) ATTGCG/AGTACT 2 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1879169631,2
    --57154524(+) TTGGAA/GAGAGA 2 -- ds50010--------
    rs5363521,2
    C,F,A,H--57154530(+) AGAGAC/GAGAGA 2 -- ds5001 trp314Minor allele frequency- G:0.12MN NA WA CSA 443
    rs1141749401,2
    F--57154540(+) AAAAGG/ACCTTT 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs618889141,2
    C--57154566(+) AACTGA/G/TGCCAT 2 -- ds50011NA 2
    rs734746611,2
    C,F--57154597(+) TGAAAG/AGTCCT 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs38877611,2
    H--57154789(-) CCTCAT/CTGAAA 2 -- ds50017Minor allele frequency- C:0.00NA MN NS EA 754
    rs1906074021,2
    --57154801(+) CTAAGC/TAGAGT 2 -- ds50010--------
    rs1114685641,2
    C--57154839(+) TCCATT/ATCAGT 2 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for PRG2 (57154267 - 57158130 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRG2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRG2
    DNA2.0 Custom Variant and Variant Library Synthesis for PRG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605601    OMIM disorders: --

    12 diseases for PRG2:    
    About MalaCards
    papillary conjunctivitis    giant papillary conjunctivitis    familial eosinophilia    vitreous syneresis
    epithelioid malignant peripheral nerve sheath tumor    eosinophilic gastroenteritis    kimura disease    atopic keratoconjunctivitis
    corneal ulcer    esophagitis    ocular cicatricial pemphigoid    atopy

    2 diseases from the University of Copenhagen DISEASES database for PRG2:
    Vitreous syneresis     Kimura disease

    Find genes that share disorders with PRG2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRG2 gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eosinophilia 67.4 12 8043431 (4), 7669668 (2), 2217619 (1), 19139036 (1) (see all 7)
    hypereosinophilic syndrome 65 2 8043431 (1), 14988154 (1)
    dermographism 57.5 2 8547035 (1)
    chronic sinusitis 51.5 2 18476621 (1), 2178530 (1)
    nasal polyps 50.6 7 2178530 (2), 11112892 (2), 18476621 (1), 1688635 (1)
    asthma 49.3 35 16982448 (6), 8007454 (2), 1953909 (2), 2178530 (2) (see all 12)
    dermatitis atopic 44.6 14 10749555 (4), 9558841 (4), 1937874 (1), 12197429 (1)
    prostate carcinoma 43.1 16 8653325 (2), 8821700 (1), 8030169 (1), 7638085 (1) (see all 6)
    allergic rhinitis 40.7 1 8587780 (1)
    pulmonary eosinophilia 39 1 2010556 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRG2 (6 documents)

    Export disorders for PRG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRG2 gene, integrated from 10 sources (see all 245):
    (articles sorted by number of sources associating them with PRG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PubMed id 1565101)1, 2, 3, 9 Yoshimatsu K.... Osawa T. (Mol. Immunol. 1992)
    2. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PubMed id 7531438)1, 2, 9 Li M.S.... Spry C.J. (Biochem. J. 1995)
    3. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PubMed id 7526035)1, 2, 9 Bonno M.... Gleich G.J. (Lab. Invest. 1994)
    4. Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity. (PubMed id 11319227)1, 2, 9 Swaminathan G.J.... Acharya K.R. (J. Biol. Chem. 2001)
    5. Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. (PubMed id 2323577)1, 2, 9 Barker R.L.... Gleich G.J. (Gene 1990)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites. (PubMed id 12421832)1, 2 Overgaard M.T.... Oxvig C. (J. Biol. Chem. 2003)
    8. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. (PubMed id 10913121)1, 2 Overgaard M.T....Oxvig C. (J. Biol. Chem. 2000)
    9. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. (PubMed id 10491647)1, 2 Overgaard M.T.... Haaning J. (Biol. Reprod. 1999)
    10. Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. (PubMed id 7539791)1, 2 Oxvig C.... Sottrup-Jensen L. (J. Biol. Chem. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5553 HGNC: 9362 AceView: PRG2andSLC43A3 Ensembl:ENSG00000186652 euGenes: HUgn5553
    ECgene: PRG2 Kegg: 5553 H-InvDB: PRG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRG2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Major_basic_protein
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_207

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRG2 gene:
    Search GeneIP for patents involving PRG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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