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Aliases for PRG2 Gene

Aliases for PRG2 Gene

  • Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein) 2 3 5
  • BMPG 3 4
  • MBP 3 4
  • Eosinophil Granule Major Basic Protein 3
  • Eosinophil Major Basic Protein 3
  • Natural Killer Cell Activator 3
  • Proteoglycan 2 Preproprotein 3
  • Bone-Marrow Proteoglycan 3
  • Proteoglycan 2 4
  • MBP1 3

External Ids for PRG2 Gene

Previous GeneCards Identifiers for PRG2 Gene

  • GC11M059548
  • GC11M058668
  • GC11M057405
  • GC11M056930
  • GC11M056911
  • GC19M000764
  • GC11M057154
  • GC11M053504

Summaries for PRG2 Gene

Entrez Gene Summary for PRG2 Gene

  • The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for PRG2 Gene

PRG2 (Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein)) is a Protein Coding gene. Diseases associated with PRG2 include corneal opacification and other ocular anomalies and asthma. Among its related pathways are ERK Signaling and Integrin Pathway. GO annotations related to this gene include carbohydrate binding and heparin binding. An important paralog of this gene is PRG3.

UniProtKB/Swiss-Prot for PRG2 Gene

  • Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Wiki entry for PRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRG2 Gene

Genomics for PRG2 Gene

Regulatory Elements for PRG2 Gene

Transcription factor binding sites by QIAGEN in the PRG2 gene promoter:

Genomic Location for PRG2 Gene

Chromosome:
11
Start:
57,386,787 bp from pter
End:
57,390,657 bp from pter
Size:
3,871 bases
Orientation:
Minus strand

Genomic View for PRG2 Gene

Genes around PRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRG2 Gene

Proteins for PRG2 Gene

  • Protein details for PRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13727-PRG2_HUMAN
    Recommended name:
    Bone marrow proteoglycan
    Protein Accession:
    P13727
    Secondary Accessions:
    • A6XMW0
    • B2R5I1
    • P81448
    • Q14227
    • Q6ICT2

    Protein attributes for PRG2 Gene

    Size:
    222 amino acids
    Molecular mass:
    25206 Da
    Quaternary structure:
    • In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
    Miscellaneous:
    • Binds heparin. Does not bind calcium.

    Three dimensional structures from OCA and Proteopedia for PRG2 Gene

    Alternative splice isoforms for PRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRG2 Gene

Proteomics data for PRG2 Gene at MOPED

Post-translational modifications for PRG2 Gene

Other Protein References for PRG2 Gene

Antibody Products

No data available for DME Specific Peptides for PRG2 Gene

Domains & Families for PRG2 Gene

Suggested Antigen Peptide Sequences for PRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13727

UniProtKB/Swiss-Prot:

PRG2_HUMAN :
  • Contains 1 C-type lectin domain.
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with PRG2: view

No data available for Gene Families for PRG2 Gene

Function for PRG2 Gene

Molecular function for PRG2 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
genes like me logo Genes that share phenotypes with PRG2: view

Animal Models for PRG2 Gene

MGI Knock Outs for PRG2:

Animal Model Products

miRNA for PRG2 Gene

miRTarBase miRNAs that target PRG2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRG2 Gene

Localization for PRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRG2 Gene

Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophils large specific granule (crystalloid core).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRG2 Gene COMPARTMENTS Subcellular localization image for PRG2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 8547309
genes like me logo Genes that share ontologies with PRG2: view

Pathways & Interactions for PRG2 Gene

genes like me logo Genes that share pathways with PRG2: view

Gene Ontology (GO) - Biological Process for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032753 positive regulation of interleukin-4 production IEA --
GO:0042035 regulation of cytokine biosynthetic process IBA --
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with PRG2: view

No data available for SIGNOR curated interactions for PRG2 Gene

Drugs & Compounds for PRG2 Gene

(24) Drugs for PRG2 Gene - From: Novoseek, DrugBank, FDA Approved Drugs, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sargramostim Approved, Investigational Pharma Target 0
Leukine Approved on November 24, 1995/ Approved November 1996 Pharma 0
calcium Nutra 0

(20) Additional Compounds for PRG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRG2: view

Transcripts for PRG2 Gene

Unigene Clusters for PRG2 Gene

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for PRG2 Gene

GeneLoc Exon Structure for
PRG2
ECgene alternative splicing isoforms for
PRG2

Expression for PRG2 Gene

mRNA expression in normal human tissues for PRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRG2 Gene

This gene is overexpressed in Whole Blood (x31.2).

Protein differential expression in normal tissues from HIPED for PRG2 Gene

This gene is overexpressed in Neutrophil (46.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRG2 Gene



SOURCE GeneReport for Unigene cluster for PRG2 Gene Hs.512633

mRNA Expression by UniProt/SwissProt for PRG2 Gene

P13727-PRG2_HUMAN
Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
genes like me logo Genes that share expression patterns with PRG2: view

Protein tissue co-expression partners for PRG2 Gene

Primer Products

In Situ Assay Products

Orthologs for PRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRG2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Prg2 35
  • 67.72 (n)
  • 56.31 (a)
Prg2 16
Prg2 36
  • 60 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PRG2 35
  • 99.1 (n)
  • 98.65 (a)
-- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Prg2 35
  • 68.47 (n)
  • 55.41 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
OneToMany
Species with no ortholog for PRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRG2 Gene

ENSEMBL:
Gene Tree for PRG2 (if available)
TreeFam:
Gene Tree for PRG2 (if available)

Paralogs for PRG2 Gene

Paralogs for PRG2 Gene

(2) SIMAP similar genes for PRG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRG2: view

Variants for PRG2 Gene

Sequence variations from dbSNP and Humsavar for PRG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_036401 A colorectal cancer sample
rs536455 - 57,387,528(+) CCAGT(A/G)GCCTC reference, missense
rs14200 -- 57,388,604(-) CAAGT(C/T)TGGAT reference, synonymous-codon
rs519628 -- 57,390,847(+) GAACA(A/G)CTCTG upstream-variant-2KB
rs490358 -- 57,389,932(+) AAGTA(A/G)GGGGA reference, synonymous-codon

Variation tolerance for PRG2 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRG2 Gene

HapMap Linkage Disequilibrium report
PRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRG2 Gene

Disorders for PRG2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PRG2 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal opacification and other ocular anomalies
  • sclerocornea with other ocular anomalies
asthma
  • asthma, protection against
atopic keratoconjunctivitis
muscle disorders
  • myopathy
vitreous syneresis
  • vitreous degeneration
- elite association - COSMIC cancer census association via MalaCards
Search PRG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRG2

Human Genome Epidemiology (HuGE) Navigator
PRG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRG2
genes like me logo Genes that share disorders with PRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRG2 Gene

Publications for PRG2 Gene

  1. Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PMID: 1565101) Yoshimatsu K. … Osawa T. (Mol. Immunol. 1992) 2 3 4 23 67
  2. [Expression of eosinophil major basic protein and neutrophil elastase in nasal polyp tissue and secretion]. (PMID: 18476621) Zhang C. … Shen H. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008) 3 23
  3. [Expression and its significance of eosinophil major basic protein in chronic rhinosinusitis]. (PMID: 18720885) Hou J. … Wang Y. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2008) 3 23
  4. Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. (PMID: 12393403) Piliponsky A.M. … Levi-Schaffer F. (Blood 2003) 3 23
  5. Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway. (PMID: 14500673) Shenoy N.G. … Thomas L.L. (J. Immunol. 2003) 3 23

Products for PRG2 Gene

Sources for PRG2 Gene

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