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Aliases for PRG2 Gene

Aliases for PRG2 Gene

  • Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein) 2 3
  • MBP 3 4 6
  • BMPG 3 4
  • Eosinophil Granule Major Basic Protein 3
  • Eosinophil Major Basic Protein 3
  • Natural Killer Cell Activator 3
  • Proteoglycan 2 Preproprotein 3
  • Bone Marrow Proteoglycan 3
  • Bone-Marrow Proteoglycan 3
  • Proteoglycan 2 4
  • MBP1 3

External Ids for PRG2 Gene

Previous GeneCards Identifiers for PRG2 Gene

  • GC11M059548
  • GC11M058668
  • GC11M057405
  • GC11M056930
  • GC11M056911
  • GC19M000764
  • GC11M057154
  • GC11M053504

Summaries for PRG2 Gene

Entrez Gene Summary for PRG2 Gene

  • The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

GeneCards Summary for PRG2 Gene

PRG2 (Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein)) is a Protein Coding gene. Diseases associated with PRG2 include corneal opacification and other ocular anomalies and giant papillary conjunctivitis. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include carbohydrate binding and heparin binding. An important paralog of this gene is ENSG00000254979.

UniProtKB/Swiss-Prot for PRG2 Gene

  • Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Wiki entry for PRG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRG2 Gene

Genomics for PRG2 Gene

Regulatory Elements for PRG2 Gene

Transcription factor binding sites by QIAGEN in the PRG2 gene promoter:

Genomic Location for PRG2 Gene

Start:
57,386,794 bp from pter
End:
57,390,657 bp from pter
Size:
3,864 bases
Orientation:
Minus strand

Genomic View for PRG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRG2 Gene

Proteins for PRG2 Gene

  • Protein details for PRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13727-PRG2_HUMAN
    Recommended name:
    Bone marrow proteoglycan
    Protein Accession:
    P13727
    Secondary Accessions:
    • A6XMW0
    • B2R5I1
    • P81448
    • Q14227
    • Q6ICT2

    Protein attributes for PRG2 Gene

    Size:
    222 amino acids
    Molecular mass:
    25206 Da
    Quaternary structure:
    • In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg.
    Miscellaneous:
    • Binds heparin. Does not bind calcium

    Three dimensional structures from OCA and Proteopedia for PRG2 Gene

    Alternative splice isoforms for PRG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRG2 Gene

Proteomics data for PRG2 Gene at MOPED

Post-translational modifications for PRG2 Gene

Other Protein References for PRG2 Gene

No data available for DME Specific Peptides for PRG2 Gene

Domains for PRG2 Gene

Suggested Antigen Peptide Sequences for PRG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13727

UniProtKB/Swiss-Prot:

PRG2_HUMAN :
  • P13727
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with PRG2: view

No data available for Gene Families for PRG2 Gene

Function for PRG2 Gene

Molecular function for PRG2 Gene

UniProtKB/Swiss-Prot Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.

Gene Ontology (GO) - Molecular Function for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with PRG2: view
genes like me logo Genes that share phenotypes with PRG2: view

Animal Models for PRG2 Gene

MGI Knock Outs for PRG2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PRG2 Gene

Localization for PRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRG2 Gene

Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophils large specific granule (crystalloid core).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRG2 Gene COMPARTMENTS Subcellular localization image for PRG2 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 8547309
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PRG2: view

Pathways for PRG2 Gene

genes like me logo Genes that share pathways with PRG2: view

Pathways by source for PRG2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002215 defense response to nematode IEA --
GO:0006955 immune response IEA --
GO:0032693 negative regulation of interleukin-10 production IEA --
GO:0032753 positive regulation of interleukin-4 production IEA --
GO:0042035 regulation of cytokine biosynthetic process IBA --
genes like me logo Genes that share ontologies with PRG2: view

Compounds for PRG2 Gene

(1) HMDB Compounds for PRG2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for PRG2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sargramostim
  • Colony-stimulating factor
83869-56-1 target

(42) Novoseek inferred chemical compound relationships for PRG2 Gene

Compound -log(P) Hits PubMed IDs
estromustine 91.1 8
estracyt 86.3 4
estramustine 86.3 29
estramustine phosphate 76.6 4
maltose 52.9 7
genes like me logo Genes that share compounds with PRG2: view

Transcripts for PRG2 Gene

Unigene Clusters for PRG2 Gene

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRG2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for PRG2 Gene

GeneLoc Exon Structure for
PRG2
ECgene alternative splicing isoforms for
PRG2

Expression for PRG2 Gene

mRNA expression in normal human tissues for PRG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRG2 Gene

This gene is overexpressed in Whole Blood (31.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRG2 Gene

SOURCE GeneReport for Unigene cluster for PRG2 Gene Hs.512633

mRNA Expression by UniProt/SwissProt for PRG2 Gene

P13727-PRG2_HUMAN
Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon.
genes like me logo Genes that share expressions with PRG2: view

In Situ Assay Products

Orthologs for PRG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
PRG2 35
  • 99.1 (n)
  • 98.65 (a)
mouse
(Mus musculus)
Mammalia Prg2 35
  • 67.72 (n)
  • 56.31 (a)
Prg2 16
Prg2 36
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Prg2 35
  • 68.47 (n)
  • 55.41 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
OneToMany
Species with no ortholog for PRG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRG2 Gene

ENSEMBL:
Gene Tree for PRG2 (if available)
TreeFam:
Gene Tree for PRG2 (if available)

Paralogs for PRG2 Gene

Paralogs for PRG2 Gene

Selected SIMAP similar genes for PRG2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRG2: view

Variants for PRG2 Gene

Sequence variations from dbSNP and Humsavar for PRG2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs14200 -- 57,388,604(-) CAAGT(C/T)TGGAT reference, synonymous-codon
rs490358 -- 57,389,932(+) AAGTA(A/G)GGGGA synonymous-codon, reference
rs519628 -- 57,390,847(+) GAACA(A/G)CTCTG upstream-variant-2KB
rs536352 -- 57,387,057(+) AGAGA(C/G)AGAGA downstream-variant-500B
rs536455 - 57,387,528(+) CCAGT(A/G)GCCTC reference, missense

Relevant External Links for PRG2 Gene

HapMap Linkage Disequilibrium report
PRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRG2 Gene

Disorders for PRG2 Gene

(2) University of Copenhagen DISEASES for PRG2 Gene

(38) Novoseek inferred disease relationships for PRG2 Gene

Disease -log(P) Hits PubMed IDs
eosinophilia 67.4 11
hypereosinophilic syndrome 65 2
dermographism 57.5 1
chronic sinusitis 51.5 2
nasal polyps 50.6 6

Relevant External Links for PRG2

Human Genome Epidemiology (HuGE) Navigator
PRG2
genes like me logo Genes that share disorders with PRG2: view

No data available for UniProtKB/Swiss-Prot for PRG2 Gene

Publications for PRG2 Gene

  1. Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PMID: 1565101) Yoshimatsu K. … Osawa T. (Mol. Immunol. 1992) 2 3 4 23
  2. Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. (PMID: 2323577) Barker R.L. … Gleich G.J. (Gene 1990) 3 4 23
  3. Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity. (PMID: 11319227) Swaminathan G.J. … Acharya K.R. (J. Biol. Chem. 2001) 3 4 23
  4. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PMID: 7526035) Bonno M. … Gleich G.J. (Lab. Invest. 1994) 3 4 23
  5. Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PMID: 7531438) Li M.S. … Spry C.J. (Biochem. J. 1995) 3 4 23

Products for PRG2 Gene

Sources for PRG2 Gene

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