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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRG2 Gene

protein-coding GIFtS: 62
GCID: GC11M057154

proteoglycan 2, bone marrow (natural killer cell activator,...

Explore 56 diseases affiliated with
PRG2 via

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Proteoglycan 2, Bone Marrow (Natural Killer Cell Activator, Eosinophil Granule Major Basic Protein)¹ ²		Eosinophil Granule Major Basic Protein²
MBP¹ ² ³ ⁵		Eosinophil Major Basic Protein²
BMPG¹ ² ³		Natural Killer Cell Activator²
MBP1²		Proteoglycan 2 Preproprotein²
Bone Marrow Proteoglycan²		Proteoglycan 2³
Bone-Marrow Proteoglycan²

External Ids:	HGNC: 9362¹	Entrez Gene: 5553²	Ensembl: ENSG00000186652⁷	OMIM: 605601⁵	UniProtKB: P13727³

Export aliases for PRG2 gene to outside databases

Previous GC identifers: GC11M059548 GC11M058668 GC11M057405 GC11M056930 GC11M056911 GC19M000764 GC11M053504

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRG2:

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High

levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex

with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg.

This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune

hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in

allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in

antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor,

reducing the activity of PAPPA

Gene Wiki entry for PRG2 (Major basic protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRG2 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRG2 promoter sequence

Search SABiosciences Chromatin IP Primers for PRG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRG2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12

PRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRG2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M057154: view genomic region (about GC identifiers)

Start:	57,154,267 bp from pter	End:	57,158,130 bp from pter
Size:	3,864 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727 (See protein sequence)

Recommended Name: Bone marrow proteoglycan precursor

Size: 222 amino acids; 25206 Da

Subunit: In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a

disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg

Subcellular location: Bone marrow proteoglycan: Secreted. Note=The proform is secreted

Subcellular location: Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle. Note=The proform

is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core)

Developmental stage: Levels of the proform increase in serum and placenta during pregnancy

Miscellaneous: Binds heparin. Does not bind calcium

2 PDB 3D structures from and Proteopedia for PRG2:

1H8U (3D)

2BRS (3D)

Secondary accessions: P81448 Q14227 Q6ICT2

Explore the universe of human proteins at neXtProt for PRG2: NX_P13727

Post-translational modifications:

Nitrated¹

View neXtProt modification sites for NX_P13727

PRG2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230174.1 NP_002719.3

ENSEMBL proteins:

ENSP00000312134 ENSP00000433231 ENSP00000433016

Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PRG2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005634	nucleus	--	--
GO:0030133	transport vesicle	IEA	--
GO:0043231	intracellular membrane-bounded organelle	--	--

PRG2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PRG2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRG2 for domains About GeneDecksing

5 InterPro domains/families:

IPR002352 Eosinophil_major_basic

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

Graphical View of Domain Structure for InterPro Entry P13727

ProtoNet protein and cluster: P13727

1 Blocks protein family: IPB002352 Eosinophil major basic protein signature

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Similarity: Contains 1 C-type lectin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Function: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in

antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor,

reducing the activity of PAPPA

miRNA Products:		OriGene 3'-UTR Clone: PRG2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRG2
		1 QIAGEN miScript miRNA Assays for microRNA that regulate PRG2:
		hsa-miR-1827
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRG2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008201	heparin binding	IEA	--
GO:0030246	carbohydrate binding	IEA	--

PRG2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PRG2:

Increased G1 DNA content

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Prg2^tm1Nal for PRG2
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prg2):

hematopoietic system

immune system

respiratory system

PRG2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

Selected targets of C/EBPbeta

Selected targets of C/EBPbeta

1.00

Allograft rejection

Asthma

0.44

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PRG2

Selected targets of C/EBPbeta

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PRG2 (see all 13)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

1 Kegg Pathway (Kegg details for PRG2):

Asthma

PRG2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRG2

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/11 Interacting proteins for PRG2 (P13727^{2, 3} ENSP00000312134⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CHD3	Q12873²^,³	MINT-63471 I2D: score=5
PAPPA	Q13219³, ENSP00000330658⁴	I2D: score=2 STRING: ENSP00000330658
PRKCZ	Q05513³, ENSP00000367830⁴	I2D: score=2 STRING: ENSP00000367830
AGT	P01019³, ENSP00000355627⁴	I2D: score=1 STRING: ENSP00000355627
CSF2	P04141³, ENSP00000296871⁴	I2D: score=2 STRING: ENSP00000296871

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	IEA	--
GO:0042742	defense response to bacterium	IEA	--

PRG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRG2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for PRG2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Myelin Basic Protein (87-99)	Major antigenic component implicated in the pathophysiology of multiple sclerosis	[118506-26-6]

1 HMDB Compound for PRG2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for PRG2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sargramostim	Colony-stimulating factor (see all 5)	83869-56-1	target	--	17383764 17600316 16522458

10/42 Novoseek chemical compound relationships for PRG2 gene (see all 42) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estromustine	91.1	9	9748122 (2), 1888147 (2), 1626200 (1), 7638085 (1) (see all 6)
estracyt	86.3	4	7638085 (2), 1888147 (1), 1626200 (1)
estramustine	86.3	38	9748122 (4), 7520576 (2), 8712706 (2), 8827085 (2) (see all 19)
estramustine phosphate	76.6	4	1626200 (1), 7638085 (1), 8827085 (1), 7714550 (1)
maltose	52.9	9	9782274 (1), 19177560 (1), 15097997 (1), 16442308 (1) (see all 7)
histamine	50.2	24	10743163 (5), 7543541 (3), 7514197 (3), 8757629 (2) (see all 10)
amylose	46.2	1	10071937 (1)
phosphatidyl ethanol	42.4	1	8541554 (1)
cytochalasin	37	2	8541554 (1), 2170521 (1)
methacholine	36.2	5	8466137 (2), 2010556 (1), 8385431 (1), 8368165 (1)

Search CenterWatch for drugs/clinical trials and news about PRG2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRG2 gene (2 alternative transcripts):

NM_001243245.1 NM_002728.4

Unigene Cluster for PRG2:

Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Hs.512633 [show with all ESTs]

Unigene Representative Sequence: BX335104

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000311862(uc001nkc.3 uc001nkd.3) ENST00000533605 ENST00000525955

ENST00000530105

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		hsa-miR-1827
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Additional cDNA sequence:

AK312195.1 BC005929.1 CR450311.1 DQ846874.1 M35670.1 M36805.1 X14088.1 X65787.1

Y00809.1

17 DOTS entries:

DT.454353 DT.100697575 DT.100697567 DT.100719032 DT.95304053 DT.100697574 DT.100842776 DT.120728609

DT.100697579 DT.120728623 DT.91771600 DT.100851914 DT.86854586 DT.91771603 DT.91771610 DT.100697572

DT.95233827

24/873 AceView cDNA sequences (see all 873):

CR617968 CR619867 CR616445 CR605665 CR609247 BM455796 CR610568 BQ723184

CR593804 CR591196 NM_199329 AI142557 CB159935 CR625586 CR619837 CR596367

BG034553 CR606081 CR624403 CR620046 CR626455 CR621593 AI074500 AA284125

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PRG2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7
SP1:
SP2:
SP3:

ECgene alternative splicing isoforms for PRG2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTCCCCTC

About this image

PRG2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Early limb mesenchymal cells (ELM cells) (Primary Cell)

Bone, Cartilage, Limb

Late limb mesenchymal cells (LLM cells) (Primary Cell)

Bone, Cartilage, Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRG2

SOURCE GeneReport for Unigene cluster: Hs.512633

UniProtKB/Swiss-Prot: PRG2_HUMAN, P13727

Tissue specificity: High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of

septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium,

ovaries, breast, prostate, bone marrow and colon

SABiosciences Expression via Pathway-Focused PCR Arrays including PRG2:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Allergy & Asthma in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PRG2 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	34(a)	1 → many	5(18205204-18206848)

ENSEMBL Gene Tree for PRG2 (if available)
TreeFam Gene Tree for PRG2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRG2 gene

ENSG00000254979² PRG3²

2 SIMAP similar genes for PRG2 using alignment to 2 protein entries: PRG2_HUMAN (see all proteins):

PRG3 SLED1

PRG2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79974275^1,2	F,	--	57154430(+)	`ATTGCG/AGTACT`	2	--	ds500¹		1		WA	118
rs187916963^1,2		--	57154524(+)	`TTGGAA/GAGAGA`	2	--	ds500¹		0	--	--	--	--
rs536352^1,2	C,F,A,H,	--	57154530(+)	`AGAGAC/GAGAGA`	2	--	ds500¹ trp³		14		MN NA WA CSA	443
rs114174940^1,2	F,	--	57154540(+)	`AAAAGG/ACCTTT`	2	--	ds500¹		1		WA	118
rs73474661^1,2	C,	--	57154597(+)	`TGAAAG/AGTCCT`	2	--	ds500¹		1		WA	2
rs3887761^1,2	H	--	57154789(-)	`CCTCAT/CTGAAA`	2	--	ds500¹		7		NA MN NS EA	754
rs190607402^1,2		--	57154801(+)	`CTAAGC/TAGAGT`	2	--	ds500¹		0	--	--	--	--
rs144365065^1,2		--	57154868(+)	`GGGAGG/TTGGAG`	2	--	ut3¹		0	--	--	--	--
rs536455^1,2	C,F,A,H,	--	57155001(+)	`CCAGTA/GGCCTC`	4	H Y	mis¹ ese³		34		MN NS EA NA WA CSA EU	8412
rs115918260^1,2		--	57155097(+)	`CTGCTG/ATGGAG`	2	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for PRG2 (57154267 - 57158130 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRG2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PRG2 for disorders           About GeneDecksing

OMIM gene information: 605601    OMIM disorders: --

20/56 diseases for PRG2 (see all 56):    About MalaCards

malignant peripheral nerve sheath tumor epithelioid malignant peripheral nerve sheath tumor ocular cicatricial pemphigoid cicatricial pemphigoid

giant papillary conjunctivitis vernal keratoconjunctivitis corneal ulcer allergic rhinitis

eosinophilic gastroenteritis papillary conjunctivitis hypereosinophilic syndrome eosinophilia

pulmonary eosinophilia connective tissue disease kimura disease rhinitis

retinal detachment keratoconjunctivitis eosinophilic esophagitis familial eosinophilia

2 diseases from the University of Copenhagen DISEASES database for PRG2:

Vitreous syneresis Kimura disease

10/38 Novoseek disease relationships for PRG2 gene (see all 38) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
eosinophilia	67.4	12	8043431 (4), 7669668 (2), 2217619 (1), 19139036 (1) (see all 7)
hypereosinophilic syndrome	65	2	8043431 (1), 14988154 (1)
dermographism	57.5	2	8547035 (1)
chronic sinusitis	51.5	2	18476621 (1), 2178530 (1)
nasal polyps	50.6	7	2178530 (2), 11112892 (2), 18476621 (1), 1688635 (1)
asthma	49.3	35	16982448 (6), 8007454 (2), 1953909 (2), 2178530 (2) (see all 12)
dermatitis atopic	44.6	14	10749555 (4), 9558841 (4), 1937874 (1), 12197429 (1)
prostate carcinoma	43.1	16	8653325 (2), 8821700 (1), 8030169 (1), 7638085 (1) (see all 6)
allergic rhinitis	40.7	1	8587780 (1)
pulmonary eosinophilia	39	1	2010556 (1)

Human Genome Epidemiology (HuGE) Navigator: PRG2 (6 documents)

Export disorders for PRG2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRG2 gene, integrated from 9 sources (see all 245):
(articles sorted by number of sources associating them with PRG2)

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Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. (PubMed id 1565101)^{1, 2, 3, 9} Yoshimatsu K.... Osawa T. (1992)
Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. (PubMed id 7531438)^{1, 2, 9} Li M.S.... Spry C.J. (1995)
Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. (PubMed id 7526035)^{1, 2, 9} Bonno M.... Gleich G.J. (1994)
Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity. (PubMed id 11319227)^{1, 2, 9} Swaminathan G.J.... Acharya K.R. (2001)
Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. (PubMed id 2323577)^{1, 2, 9} Barker R.L.... Gleich G.J. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites. (PubMed id 12421832)^{1, 2} Overgaard M.T.... Oxvig C. (2003)
Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. (PubMed id 10913121)^{1, 2} Overgaard M.T....Oxvig C. (2000)
Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. (PubMed id 10491647)^{1, 2} Overgaard M.T.... Haaning J. (1999)
Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. (PubMed id 7539791)^{1, 2} Oxvig C.... Sottrup-Jensen L. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5553	HGNC: 9362	AceView: PRG2andSLC43A3	Ensembl:ENSG00000186652	euGenes: HUgn5553
ECgene: PRG2	Kegg: 5553	H-InvDB: PRG2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PRG2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRG2	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Major_basic_protein
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_207

Intellectual Property for PRG2 gene
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GeneCards and IP:
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