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GIFtS

PREX2 Gene

protein-coding   GIFtS: 49
GCID: GC08P068864

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange...

(Previous name: DEP domain containing 2 )
(Previous symbol: DEPDC2)
  Search for PREX2
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Biological research products
for PREX2    

Aliases
for PREX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 21 2     FLJ129871
DEPDC21 2 3 5     DEP Domain Containing 21
DEP.21 2     6230420N16Rik2
P-REX21 2     Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein2
DEP Domain-Containing Protein 22 3     P-Rex23
PtdIns(3,4,5)-Dependent Rac Exchanger 22 3     

External Ids:    HGNC: 229501   Entrez Gene: 802432   Ensembl: ENSG000000468897   OMIM: 6121395   UniProtKB: Q70Z353   

Export aliases for PREX2 gene to outside databases

Previous GC identifers: GC08P069027 GC08P064357


Summaries
for PREX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PREX2_HUMAN, Q70Z35
Function: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP
for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma
subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important
mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide
3-kinase




Genomic Views
for PREX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PREX2 gene promoter:
         GR   GR-beta   NRSF form 1   CUTL1   NRSF form 2   E47   HFH-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PREX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PREX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PREX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.2   Ensembl cytogenetic band:  8q13.2   HGNC cytogenetic band: 8q13.1

PREX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PREX2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P068864:  view genomic region     (about GC identifiers)

Start:
 68,864,353 bp from pter      End:
 69,149,265 bp from pter
Size:
 284,913 bases      Orientation:
 plus strand

Proteins
for PREX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PREX2_HUMAN, Q70Z35 (See protein sequence)
Recommended Name: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein  
Size: 1606 amino acids; 182622 Da
Subunit: Interacts with RAC1
Sequence caution: Sequence=AK024079; Type=Frameshift; Positions=1134; Sequence=BAB14375.1; Type=Erroneous initiation;
Secondary accessions: Q32KL0 Q32KL1 Q6R7Q3 Q6R7Q4 Q9H805 Q9H961
Alternative splicing: 3 isoforms:  Q70Z35-1   Q70Z35-2   Q70Z35-3   

Explore the universe of human proteins at neXtProt for PREX2: NX_Q70Z35

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q70Z35

    • PREX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_079146.2  NP_079446.3  

    ENSEMBL proteins: 
     ENSP00000288368  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: PREX2
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    Novus Biologicals PREX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PREX2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--


    PREX2 for ontologies           About GeneDecksing



    PREX2 Antibody Products: 
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    Uscn ELISAs and CLIAs for PREX2

    Protein Domains /
    Families
    for PREX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PREX2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR001331 GDS_CDC24_CS

    Graphical View of Domain Structure for InterPro Entry Q70Z35

    ProtoNet protein and cluster: Q70Z35

    3 Blocks protein families:
    IPB000219 DH domain
    IPB001478 PDZ/DHR/GLGF domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PREX2_HUMAN, Q70Z35
    Domain: PH domain confers substrate specificity and recognition. Able to discriminate between RAC1, RHOA, and CDC42
    Domain: DH domain alone was unable to confer substrate specificity and recognition
    Similarity: Contains 2 DEP domains
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 2 PDZ (DHR) domains
    Similarity: Contains 1 PH domain


    Function
    for PREX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PREX2_HUMAN, Q70Z35
    Function: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP
    for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma
    subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important
    mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide
    3-kinase

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PREX2
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    SwitchGear 3'UTR luciferase reporter plasmid: PREX2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PREX2 (see all 7)
    OriGene shRNA RFP: PREX2
    OriGene siRNA: PREX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PREX2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PREX2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PREX2 (see all 5)
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    Cell Line
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    Search LifeMap BioReagents cell lines for PREX2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005543phospholipid binding IEA--
    GO:0030675Rac GTPase activator activity IDA15304343
    GO:0030676Rac guanyl-nucleotide exchange factor activity IDA15304343


    PREX2 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prex2):
     behavior/neurological  growth/size  nervous system 

    PREX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PREX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of RAC1 activity
    		Regulation of RAC1 activity1.00


    1 BioSystems Pathway for PREX2 
        Regulation of RAC1 activity


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PREX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for PREX2 (Q70Z353 ENSP000002883684) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    MTORP423453, ENSP000003545584I2D: score=1 STRING: ENSP00000354558
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    SMAD2Q157963I2D: score=1 
    RAC1ENSP000003484614STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway IDA15304343
    GO:0032855positive regulation of Rac GTPase activity IDA15304343
    GO:0035556intracellular signal transduction IEA--


    PREX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PREX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PREX2

    3 HMDB Compounds for PREX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about PREX2 

    Transcripts
    for PREX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PREX2 gene (2 alternative transcripts): 
    NM_024870.2  NM_025170.4  

    Unigene Cluster for PREX2:

    Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
    Hs.591867  [show with all ESTs]
    Unigene Representative Sequence: AJ437636
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288368(uc003xxv.1) ENST00000529398(uc003xxu.1) ENST00000517617(uc011lez.1)
    ENST00000522247 ENST00000520235

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): PREX2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PREX2
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    SwitchGear 3'UTR luciferase reporter plasmid: PREX2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PREX2 (see all 7)
    OriGene shRNA RFP: PREX2
    OriGene siRNA: PREX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PREX2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PREX2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): PREX2 (NM_024870)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PREX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PREX2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PREX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PREX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PREX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PREX2

    Additional cDNA sequence: 

    AJ437636.2 AK023049.1 AK024079.1 AK294299.1 AY508996.1 AY508997.1 AY570973.1 BC036055.1 
    BC068571.1 

    5 DOTS entries:

    DT.102826950  DT.91695693  DT.95189583  DT.91796922  DT.40301925 

    24 AceView cDNA sequences:

    AL699922 AI699567 NM_025170 NM_024870 BX107321 AY508997 AU130001 CA392491 
    AJ437636 CA392492 BC036055 AK023049 AY508996 AK024079 AW236486 BI457806 
    BC068571 AU117024 BI598613 BX502349 AU143960 AA627318 BU663683 BF852508 

    GeneLoc Exon Structure


    Expression
    for PREX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PREX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTATATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PREX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PREX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PREX2

    SOURCE GeneReport for Unigene cluster: Hs.591867

    UniProtKB/Swiss-Prot: PREX2_HUMAN, Q70Z35
    Tissue specificity: Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood
    leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed
    in the heart

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREX2

    Orthologs
    for PREX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PREX2 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PREX21 phosphatidylinositol-3,4,5-trisphosphate-dependent more 82.09(n)
    90.6(a)    		   420172  XM_418285.3  XP_418285.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PREX26
    		 --
    		 88(a)
    		 1 ↔ 1
    		 4(31444401-31545540)
    zebrafish
    (Danio rerio)    		 Actinopterygii prex21 phosphatidylinositol-3,4,5-trisphosphate-dependent more 71.42(n)
    78.92(a)    		   557288  XM_001923322.1  XP_001923357.1 


    ENSEMBL Gene Tree for PREX2 (if available)
    TreeFam Gene Tree for PREX2 (if available) 

    Paralogs
    for PREX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PREX2 gene
    ARHGEF62  VAV12  PLEKHG22  PLEKHG32  ARHGEF72  TIAM12  SPATA132  TIAM22  
    ARHGEF92  VAV32  VAV22  ARHGEF42  PLEKHG12  PREX12  
    12 SIMAP similar genes for PREX2 using alignment to 2 protein entries:     PREX2_HUMAN (see all proteins):
    PREX1    ARHGEF4    ARHGEF7    DKFZp434G2016    MCF2    NET1
    SPATA13    ARHGEF9    MCF2L    TIAM1    TIAM2    ARHGEF38

    PREX2 for paralogs           About GeneDecksing



    Genomic Variants
    for PREX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5097 NCBI SNPs in PREX2 are shown (see all 5097)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1849350711,2
    		--68862642(+) TGCAGA/CCCTAA 2 -- us2k10--------
    rs1894939741,2
    		--68862772(+) TATTTA/GTTTGC 2 -- us2k10--------
    rs1156962881,2
    		--68862860(+) GCTTGC/TATTTC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1810372221,2
    		--68862902(+) CTTCCA/GCTTCT 2 -- us2k10--------
    rs1852849231,2
    		--68862960(+) TTTGCA/CCTTTG 2 -- us2k10--------
    rs1416761001,2
    		--68863233(+) AAGCAA/TCTTTA 2 -- us2k10--------
    rs1912221181,2
    		--68863239(+) CTTTAC/TGTTTT 2 -- us2k10--------
    rs1420251061,2
    		C,--68863348(+) TAGAC-/TGTT  
                TGAAG     		2 -- us2k10--------
    rs600139571,2
    		C--68863350(+) GACTG-/TTTG  
                AAGTT     		2 -- us2k10--------
    rs1819352991,2
    		--68863390(+) CAATTA/CAAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PREX2 (68864353 - 69114353 bp, first 250kb of PREX2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for PREX2
         1 CNV: 100380
         7 Indels: 47576 82639 70383 95492 10913 70385 59487

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PREX2
    DNA2.0 Custom Variant and Variant Library Synthesis for PREX2

    Disorders / Diseases
    for PREX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PREX2 for disorders           About MalaCards

    PREX2 for disorders           About GeneDecksing

    OMIM gene information: 612139    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: PREX2 (1 document)

    Export disorders for PREX2 gene to outside databases

    Publications
    for PREX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PREX2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with PREX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. (PubMed id 15304342)1, 2, 3 Rosenfeldt H.... Gutkind J.S. (2004)
    2. P-Rex2, a new guanine-nucleotide exchange factor for Rac. (PubMed id 15304343)1, 2, 3 Donald S....Welch H.C. (2004)
    3. Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2. (PubMed id 15897194)1, 2 Joseph R.E. and Norris F.A. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Melanoma genome sequencing reveals frequent PREX2 muta tions. (PubMed id 22622578)1 Berger M.F....Garraway L.A. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Activation of the PI3K pathway in cancer through inhi bition of PTEN by exchange factor P-REX2a. (PubMed id 19729658)1 Fine B....Parsons R. (2009)
    8. P-REX2a driving tumorigenesis by PTEN inhibition. (PubMed id 19861688)1 Leslie N.R. (2009)
    9. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. (PubMed id 17565979)1 Hernandez-Negrete I....Vazquez-Prado J. (2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

    External Searches for PREX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PREX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80243 HGNC: 22950 AceView: DEPDC2 Ensembl:ENSG00000046889 euGenes: HUgn80243
    ECgene: PREX2 H-InvDB: PREX2

    Other Databases showing PREX2 gene

    (According to HUGE)
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    Specialized Databases showing PREX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PREX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PREX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PREX2 gene:
    Search GeneIP for patents involving PREX2

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