Aliases for PREX2 Gene
External Ids for PREX2 Gene
Previous HGNC Symbols for PREX2 Gene
Previous GeneCards Identifiers for PREX2 Gene
GeneCards Summary for PREX2 Gene
PREX2 (Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2) is a Protein Coding gene. Among its related pathways are Regulation of RAC1 activity. GO annotations related to this gene include GTPase activator activity and Rac guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for PREX2 Gene
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.