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Aliases for PREX1 Gene

Aliases for PREX1 Gene

  • Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 2 3
  • Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 1 2 3 5
  • PtdIns(3,4,5)-Dependent Rac Exchanger 1 3 4
  • PIP3 Dependent Rac Exchange Factor 1 2 3
  • P-REX1 3 4
  • KIAA1415 4

External Ids for PREX1 Gene

Previous GeneCards Identifiers for PREX1 Gene

  • GC20M047879
  • GC20M047926
  • GC20M046674
  • GC20M047240
  • GC20M043990

Summaries for PREX1 Gene

Entrez Gene Summary for PREX1 Gene

  • The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for PREX1 Gene

PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) is a Protein Coding gene. Among its related pathways are Regulation of RAC1 activity and G-protein signaling_Rac2 regulation pathway. GO annotations related to this gene include enzyme binding and phospholipid binding. An important paralog of this gene is ARHGEF7.

UniProtKB/Swiss-Prot for PREX1 Gene

  • Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Gene Wiki entry for PREX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PREX1 Gene

Genomics for PREX1 Gene

Regulatory Elements for PREX1 Gene

Promoters for PREX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PREX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PREX1 Gene

Chromosome:
20
Start:
48,624,249 bp from pter
End:
48,827,883 bp from pter
Size:
203,635 bases
Orientation:
Minus strand

Genomic View for PREX1 Gene

Genes around PREX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PREX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PREX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PREX1 Gene

Proteins for PREX1 Gene

  • Protein details for PREX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCU6-PREX1_HUMAN
    Recommended name:
    Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
    Protein Accession:
    Q8TCU6
    Secondary Accessions:
    • E1P5X9
    • Q5JS95
    • Q5JS96
    • Q69YL2
    • Q7Z2L9
    • Q9BQH0
    • Q9BX55
    • Q9H4Q6
    • Q9P2D2
    • Q9UGQ4

    Protein attributes for PREX1 Gene

    Size:
    1659 amino acids
    Molecular mass:
    186203 Da
    Quaternary structure:
    • Interacts preferentially with RAC2 (By similarity). Interacts with RAC1.

    Three dimensional structures from OCA and Proteopedia for PREX1 Gene

    Alternative splice isoforms for PREX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PREX1 Gene

Proteomics data for PREX1 Gene at MOPED

Post-translational modifications for PREX1 Gene

  • Ubiquitination at Lys 624
  • Modification sites at PhosphoSitePlus

Other Protein References for PREX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PREX1 (PREX1)

No data available for DME Specific Peptides for PREX1 Gene

Domains & Families for PREX1 Gene

Suggested Antigen Peptide Sequences for PREX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCU6

UniProtKB/Swiss-Prot:

PREX1_HUMAN :
  • Contains 2 DEP domains.
Domain:
  • Contains 2 DEP domains.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PREX1: view

Function for PREX1 Gene

Molecular function for PREX1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Gene Ontology (GO) - Molecular Function for PREX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS 12123595
GO:0005543 phospholipid binding IDA 11955434
genes like me logo Genes that share ontologies with PREX1: view
genes like me logo Genes that share phenotypes with PREX1: view

Animal Models for PREX1 Gene

MGI Knock Outs for PREX1:

Animal Model Products

miRNA for PREX1 Gene

miRTarBase miRNAs that target PREX1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PREX1 Gene

Localization for PREX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PREX1 Gene

Cytoplasm, cytosol. Cell membrane. Note=Mainly cytosolic. Some amount is apparently associated to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PREX1 Gene COMPARTMENTS Subcellular localization image for PREX1 gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PREX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS 12123595
genes like me logo Genes that share ontologies with PREX1: view

Pathways & Interactions for PREX1 Gene

genes like me logo Genes that share pathways with PREX1: view

Gene Ontology (GO) - Biological Process for PREX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006801 superoxide metabolic process TAS 12123595
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0030041 actin filament polymerization TAS 12123595
GO:0030217 T cell differentiation IEA --
GO:0035023 regulation of Rho protein signal transduction IEA --
genes like me logo Genes that share ontologies with PREX1: view

No data available for SIGNOR curated interactions for PREX1 Gene

Drugs & Compounds for PREX1 Gene

(3) Drugs for PREX1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(381) Additional Compounds for PREX1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with PREX1: view

Transcripts for PREX1 Gene

Unigene Clusters for PREX1 Gene

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PREX1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a ·
SP1:
SP2:
SP3:

ExUns: 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40
SP1:
SP2:
SP3: -

Relevant External Links for PREX1 Gene

GeneLoc Exon Structure for
PREX1
ECgene alternative splicing isoforms for
PREX1

Expression for PREX1 Gene

mRNA expression in normal human tissues for PREX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PREX1 Gene

This gene is overexpressed in Whole Blood (x12.1).

Protein differential expression in normal tissues from HIPED for PREX1 Gene

This gene is overexpressed in Lymph node (17.0), Monocytes (10.5), NK cells (10.4), and Peripheral blood mononuclear cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PREX1 Gene



SOURCE GeneReport for Unigene cluster for PREX1 Gene Hs.153310

mRNA Expression by UniProt/SwissProt for PREX1 Gene

Q8TCU6-PREX1_HUMAN
Tissue specificity: Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
genes like me logo Genes that share expression patterns with PREX1: view

Protein tissue co-expression partners for PREX1 Gene

Primer Products

In Situ Assay Products

Orthologs for PREX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PREX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PREX1 35
  • 90.73 (n)
  • 94.12 (a)
PREX1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PREX1 35
  • 91.02 (n)
  • 94.61 (a)
PREX1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prex1 35
  • 87.02 (n)
  • 91.19 (a)
Prex1 16
Prex1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PREX1 35
  • 96.44 (n)
  • 95.96 (a)
PREX1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prex1 35
  • 87.27 (n)
  • 91.24 (a)
oppossum
(Monodelphis domestica)
Mammalia PREX1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PREX1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PREX1 35
  • 74.4 (n)
  • 82.05 (a)
PREX1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PREX1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prex1 35
  • 72.85 (n)
  • 79.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68772 35
zebrafish
(Danio rerio)
Actinopterygii prex1 35
  • 68.37 (n)
  • 68.95 (a)
prex1 36
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for PREX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PREX1 Gene

ENSEMBL:
Gene Tree for PREX1 (if available)
TreeFam:
Gene Tree for PREX1 (if available)

Paralogs for PREX1 Gene

(5) SIMAP similar genes for PREX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PREX1: view

Variants for PREX1 Gene

Sequence variations from dbSNP and Humsavar for PREX1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs16993997 - 48,642,225(+) CATGA(C/T)TGGCC reference, missense
rs2664521 - 48,636,612(+) CTGCT(C/T)GGAGA reference, missense
rs3936192 - 48,629,539(-) TGGGA(C/G)TGTGG reference, missense
rs7271583 - 48,657,077(+) AGGGC(A/G)GCGGG upstream-variant-2KB, reference, missense
rs6012504 - 48,646,011(+) GGATG(C/T)GTCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PREX1 Gene

Variant ID Type Subtype PubMed ID
nsv833998 CNV Loss 17160897
nsv828735 CNV Gain 20364138
nsv525312 CNV Loss 19592680
nsv178670 CNV Loss 16902084
esv2669528 CNV Deletion 23128226
esv2722483 CNV Deletion 23290073
nsv3407 CNV Insertion 18451855
esv991815 CNV Deletion 20482838
esv2665889 CNV Deletion 23128226

Variation tolerance for PREX1 Gene

Residual Variation Intolerance Score: 9.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.43; 95.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PREX1 Gene

HapMap Linkage Disequilibrium report
PREX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PREX1 Gene

Disorders for PREX1 Gene

Relevant External Links for PREX1

Genetic Association Database (GAD)
PREX1
Human Genome Epidemiology (HuGE) Navigator
PREX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PREX1

No disorders were found for PREX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PREX1 Gene

Publications for PREX1 Gene

  1. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine- nucleotide exchange factor for Rac. (PMID: 11955434) Welch H.C.E. … Stephens L.R. (Cell 2002) 2 3 4 67
  2. Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. (PMID: 16301320) Mayeenuddin L.H. … Garrison J.C. (J. Biol. Chem. 2006) 2 3 23
  3. Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked to Rac activation, endothelial cell migration, and in vitro angiogenesis. (PMID: 20018810) Carretero-Ortega J. … VA!zquez-Prado J. (Mol. Pharmacol. 2010) 3 23
  4. Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. (PMID: 20074642) Nie B. … Ye R.D. (Cell. Signal. 2010) 3 23
  5. Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. (PMID: 19305425) Qin J. … Tu Y. (Oncogene 2009) 3 23

Products for PREX1 Gene

Sources for PREX1 Gene

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