Aliases for PREX1 Gene
External Ids for PREX1 Gene
Previous GeneCards Identifiers for PREX1 Gene
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for PREX1 Gene
PREX1 (Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1) is a Protein Coding gene. Among its related pathways are Inhibitory action of Lipoxins on Superoxide production in neutrophils and Regulation of RAC1 activity. GO annotations related to this gene include enzyme binding and phospholipid binding. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for PREX1 Gene
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.