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PREP Gene

protein-coding   GIFtS: 63
GCID: GC06M105725

Prolyl Endopeptidase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prolyl Endopeptidase1 2     EC 3.4.21.263 8
Post-Proline Cleaving Enzyme2 3     DJ355L5.1 (Prolyl Endopeptidase)2
PE2 3     Prolyl Oligopeptidase2
PEP2 3     

External Ids:    HGNC: 93581   Entrez Gene: 55502   Ensembl: ENSG000000853777   OMIM: 6004005   UniProtKB: P481473   

Export aliases for PREP gene to outside databases

Previous GC identifers: GC06M105561 GC06M105748 GC06M105771 GC06M105832 GC06M103168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PREP Gene:
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal
side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases
have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PREP Gene:
PREP (prolyl endopeptidase) is a protein-coding gene. Diseases associated with PREP include fibromyalgia, and trypanosomiasis. GO annotations related to this gene include serine-type exopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PREPL.

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147
Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to
approximately 30 amino acids long

Gene Wiki entry for PREP (Prolyl endopeptidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PREP gene promoter:
         HOXA9   HOXA9B   AML1a   Meis-1b   FOXJ2 (long isoform)   Chx10   FOXJ2   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPREP promoter sequence
   Search Chromatin IP Primers for PREP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PREP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22

PREP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PREP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M105725:  view genomic region     (about GC identifiers)

Start:
105,725,440 bp from pter      End:
105,850,999 bp from pter
Size:
125,560 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147 (See protein sequence)
Recommended Name: Prolyl endopeptidase  
Size: 710 amino acids; 80700 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for PREP:
3DDU (3D)    
Secondary accessions: Q8N6D4

Explore the universe of human proteins at neXtProt for PREP: NX_P48147

Explore proteomics data for PREP at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Ubiquitination2 at Lys516
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PREP (P48147) (see all 22)
     KQHFEWL  TKIPMFI  YGGFNIS  QDYHGHK 


    See PREP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002717.3  
    ENSEMBL proteins: 
     ENSP00000358106   ENSP00000401796  

    PREP Human Recombinant Protein Products:

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    Sino Biological Cell Lysate for PREP
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    Cloud-Clone Corp. Proteins for PREP

    PREP Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PREP

    PREP Assay Products:

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    Cloud-Clone Corp. CLIAs for PREP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001375 Peptidase_S9
     IPR002471 Pept_S9_AS
     IPR002470 Peptidase_S9A
     IPR023302 Pept_S9A_N

    Graphical View of Domain Structure for InterPro Entry P48147

    ProtoNet protein and cluster: P48147

    2 Blocks protein domains:
    IPB002470 Prolyl oligopeptidase serine protease (S9A) signature
    IPB002471 Prolyl endopeptidase


    UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147
    Similarity: Belongs to the peptidase S9A family


    PREP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPCE_HUMAN, P48147
    Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to
    approximately 30 amino acids long
    Catalytic activity: Hydrolysis of Pro- -Xaa >> Ala- -Xaa in oligopeptides

         Genatlas biochemistry entry for PREP:
    prolyl oligopeptidase,alpha/beta hydrolase fold family

         Enzyme Number (IUBMB): EC 3.4.21.261 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS7959018
    GO:0070008serine-type exopeptidase activity IEA--
         
    PREP for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prep):
     adipose tissue  behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  nervous system  renal/urinary system 

    PREP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PREP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PREP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PREP

    miRNA
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    miRTarBase miRNAs that target PREP:
    hsa-mir-1301-3p (MIRT035971)

    Block miRNA regulation of human, mouse, rat PREP using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PREP:
    hsa-miR-577 hsa-miR-3163 hsa-miR-513b hsa-miR-518a-5p hsa-miR-3143 hsa-miR-129-3p hsa-miR-3148 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidPREP 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat PREP

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PREP

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PPCE_HUMAN, P48147: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--

    PREP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PREP
    Interactions:

        Search GeneGlobe Interaction Network for PREP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for PREP (P481473 ENSP000003581064) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    OXTP011783, ENSP000002173864I2D: score=1 STRING: ENSP00000217386
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    NTSP309903, ENSP000002560104I2D: score=1 STRING: ENSP00000256010
    TAC1P203663, ENSP000003211064I2D: score=1 STRING: ENSP00000321106
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS9695945

    PREP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for PREP
      Browse compounds at ApexBio 

    Browse Tocris compounds for PREP (PPCE)

    3 HMDB Compounds for PREP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arginine vasopressin 1-8Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg;Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg [Disulfide Bridge: 1-6];des-Gly-NH(,2)('9),[Arg('8)]-Vasopressin 37552-33-3--
    Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--
    Oxytocin 1-8Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu ----

    9 DrugBank Compounds for PREP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Hydroxy-1-Thio-Glycerol-- --target--17139284 17016423 10592235
    Double Oxidized Cysteine-- --target--17139284 17016423 10592235
    Monothioglycerol-- --target--17139284 17016423 10592235
    OxytocinPitocin (see all 2)50-56-6enzymesubstrate6361010 3544718 11495689
    S-Oxy Cysteine-- --target--17139284 17016423 10592235
    (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one-- --target--10592235
    1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one-- --target--10592235
    2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione-- --target--10592235
    Z-Pro-Prolinal-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PREP gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poststatin 92.2 12 8931723 (3), 8931724 (2), 8968396 (2), 8931725 (2) (see all 6)
    z-pro-prolinal 91.1 10 16942854 (2), 1980725 (1), 18927208 (1), 20024801 (1) (see all 6)
    proline 75 43 15509157 (2), 8652620 (1), 8951032 (1), 15217351 (1) (see all 30)
    serine 72.2 70 9325271 (3), 9148758 (2), 1995635 (2), 7927537 (2) (see all 56)
    gluten 66.8 11 16206502 (2), 16136593 (1), 16690904 (1), 18836204 (1) (see all 8)
    thimet 63.3 2 9876288 (1), 9879742 (1)
    gliadin 56 7 15143130 (3), 14600421 (1), 16143118 (1), 16230098 (1) (see all 5)
    deae-cellulose 32.2 1 11137456 (1)
    tripeptide 25.4 2 8652620 (1), 2175370 (1)
    aprotinin 22.3 2 7588785 (2)



    PREP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PREP gene: 
    NM_002726.4  

    Unigene Cluster for PREP:

    Prolyl endopeptidase
    Hs.436564  [show with all ESTs]
    Unigene Representative Sequence: NM_002726
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369110(uc003prc.3) ENST00000448705

    miRNA
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    Block miRNA regulation of human, mouse, rat PREP using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate PREP:
    hsa-miR-577 hsa-miR-3163 hsa-miR-513b hsa-miR-518a-5p hsa-miR-3143 hsa-miR-129-3p hsa-miR-3148 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidPREP 3' UTR sequence
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    Additional mRNA sequence: 

    AB020018.1 AB028867.1 AK314195.1 AY660966.1 BC030636.2 D21102.1 X74496.1 

    7 DOTS entries:

    DT.100783673  DT.453965  DT.100000836  DT.121318525  DT.121318533  DT.97802437  DT.95179708 

    Selected AceView cDNA sequences (see all 166):

    BU617058 AI888722 D25810 BQ889182 AA594106 BF724523 BU931903 BM828521 
    BM016994 CA307633 AA860678 CA308061 CD108093 CA306524 BU160369 BG698006 
    AW778949 BM791205 AA974681 AA338078 BG744822 BQ028398 CA430997 AA419493 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PREP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGACTT
    PREP Expression
    About this image


    PREP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PREP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PREP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436564
        Custom PCR Arrays for PREP
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    QuantiFast Probe-based Assays in human, mouse, rat PREP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PREP gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prep1 , 5 prolyl endopeptidase1, 5 88.29(n)1
    95.91(a)1
      10 (23.27 cM)5
    190721  NM_011156.21  NP_035286.11 
     450672145 
    chicken
    (Gallus gallus)
    Aves PREP1 prolyl endopeptidase 81.1(n)
    90.41(a)
      421785  NM_001006410.1  NP_001006410.1 
    lizard
    (Anolis carolinensis)
    Reptilia PREP6
    prolyl endopeptidase
    87(a)
    1 ↔ 1
    GL343430.1(686187-773002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144502 Xenopus laevis, Similar to prolyl endopeptidase, clone more 78.75(n)    BC047161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prep1 prolyl endopeptidase 70.2(n)
    76.13(a)
      553791  NM_001020753.1  NP_001018589.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53551 , 3 prolyl oligopeptidase3
    CG53551
    53(a)
    (best of 2)3
    57.18(n)1
    55.19(a)1
      31E13
    344211  NM_135553.41  NP_609397.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G761401 AT1G76140 60.17(n)
    57.89(a)
      843946  NM_106263.4  NP_177741.3 
    rice
    (Oryza sativa)
    Liliopsida Os.155412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.84(n)    AK071405.1 


    ENSEMBL Gene Tree for PREP (if available)
    TreeFam Gene Tree for PREP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PREP gene
    PREPL2  

    PREP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PREP (see all 2714)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786521931,2
    --103257121(+) TTTTTT/AAAACA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs599028291,2
    C,F--105722656(+) TATGGA/TTGAAA 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs11493041,2
    C,F,A--105722716(-) AAAAAA/GAAAAG 1 -- ds50011Minor allele frequency- G:0.15WA 118
    rs1433893461,2
    C--105722729(+) TTTCC-/AGTA  
            
    AGTAA
    1 -- ds50010--------
    rs1463398881,2
    C--105722778(+) AGGAG-/AAAC  
            
    AAACA
    1 -- ds50010--------
    rs1398142701,2
    --105722824(+) TGCTTA/GGATAT 1 -- ds50010--------
    rs722502161,2
    C--105722837(+) GTATC-/TGTT  
            
    TGTTT
    1 -- ds50010--------
    rs1999098311,2
    --105722844(+) TTTGT-/TTGG  
            
    ATAAT
    1 -- ds50010--------
    rs1171858971,2
    F--105722858(+) TTACTC/TATGTG 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs596796541,2
    C,F--105722989(+) GGAGGC/GATCCA 1 -- ds50014Minor allele frequency- G:0.15NA CSA WA 242

    HapMap Linkage Disequilibrium report for PREP (105725440 - 105850999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PREP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886530CNV Loss21882294
    nsv886529CNV Loss21882294
    esv28038CNV Loss19812545
    esv7369OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600400    OMIM disorders: --

    Selected diseases for PREP (see all 26):    
    About MalaCards
    fibromyalgia    trypanosomiasis    post-traumatic stress disorder    celiac disease
    bulimia nervosa    bipolar disorder    otitis media    relapsing-remitting multiple sclerosis
    b-cell chronic lymphocytic leukemia    anorexia nervosa    chronic lymphocytic leukemia    schizophrenia
    osteoarthritis    alzheimer's disease    dementia    neuroblastoma
    multiple sclerosis    renal cell carcinoma    diabetes mellitus    arthritis

    2 diseases from the University of Copenhagen DISEASES database for PREP:
    Amnestic disorder     Celiac disease

    PREP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PREP gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celiac disease 65.9 10 16206502 (2), 16143118 (2), 18836204 (2), 16136593 (1) (see all 7)
    memory disorders 50.8 3 12202494 (1), 12228249 (1), 10747969 (1)
    amnesia 43.5 2 15713471 (1), 11915948 (1)
    trypanosomiasis 40.8 1 11915948 (1)
    alzheimers disease 34.3 5 16187206 (1), 11711876 (1), 17703733 (1), 16390203 (1) (see all 5)
    bipolar disorder 28 1 19593439 (1)
    neurodegenerative diseases 22.1 2 16092940 (1), 16086671 (1)
    schizophrenia 13.5 3 10363664 (1), 19593439 (1), 9802123 (1)
    major depression 9.3 5 8038298 (2), 8570777 (1), 9802123 (1)
    fibromyalgia 3.97 3 9723150 (2), 11543693 (1)

    Genetic Association Database (GAD): PREP
    Human Genome Epidemiology (HuGE) Navigator: PREP (11 documents)

    Export disorders for PREP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PREP gene, integrated from 10 sources (see all 247):
    (articles sorted by number of sources associating them with PREP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. (PubMed id 7959018)1, 2, 3, 9 Vanhoof G.... Scharpe S. (Gene 1994)
    2. The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family. (PubMed id 7588785)1, 2, 9 Goossens F....Scharpe S. (Eur. J. Biochem. 1995)
    3. Molecular cloning and characterization of prolyl endopeptidase from human T cells. (PubMed id 8089089)1, 2, 9 Shirasawa Y.... Hirashima A. (J. Biochem. 1994)
    4. No association between the PREP gene and lithium responsive bipolar disorder. (PubMed id 17324276)1, 4, 9 Mamdani F....Turecki G. (BMC Psychiatry 2007)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PubMed id 19795399)1, 4 Malhotra A....Hanson R.L. (Diabetes Metab. Res. Rev. 2009)
    8. Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. (PubMed id 16092940)1, 9 Schulz I....Rossner S. (J. Neurochem. 2005)
    9. Distribution of prolyl endopeptidase activities in rat and human brain. (PubMed id 11792464)1, 9 Irazusta J....Casis L. (Neurochem. Int. 2002)
    10. Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. (PubMed id 15380924)1, 9 Valdivia A....Casis L. (Regul. Pept. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5550 HGNC: 9358 AceView: PREP Ensembl:ENSG00000085377 euGenes: HUgn5550
    ECgene: PREP H-InvDB: PREP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PREP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PREP gene:
    Search GeneIP for patents involving PREP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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