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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PREP Gene

protein-coding   GIFtS: 61
GCID: GC06M105725

Prolyl Endopeptidase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prolyl Endopeptidase1 2     EC 3.4.21.263 8
Post-Proline Cleaving Enzyme2 3     DJ355L5.1 (Prolyl Endopeptidase)2
PE2 3     Prolyl Oligopeptidase2
PEP2 3     

External Ids:    HGNC: 93581   Entrez Gene: 55502   Ensembl: ENSG000000853777   OMIM: 6004005   UniProtKB: P481473   

Export aliases for PREP gene to outside databases

Previous GC identifers: GC06M105561 GC06M105748 GC06M105771 GC06M105832 GC06M103168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PREP Gene:
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal
side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases
have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PREP Gene: 
PREP (prolyl endopeptidase) is a protein-coding gene. Diseases associated with PREP include fibromyalgia, and post-traumatic stress disorder. GO annotations related to this gene include serine-type exopeptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PREPL.

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147
Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to
approximately 30 amino acids long

Gene Wiki entry for PREP (Prolyl endopeptidase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PREP gene promoter:
         HOXA9   HOXA9B   AML1a   Meis-1b   FOXJ2 (long isoform)   Chx10   FOXJ2   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPREP promoter sequence
   Search SABiosciences Chromatin IP Primers for PREP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PREP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22

PREP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PREP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M105725:  view genomic region     (about GC identifiers)

Start:
105,725,440 bp from pter      End:
105,850,999 bp from pter
Size:
125,560 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147 (See protein sequence)
Recommended Name: Prolyl endopeptidase  
Size: 710 amino acids; 80700 Da
Subunit: Monomer
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for PREP:
3DDU (3D)    
Secondary accessions: Q8N6D4

Explore the universe of human proteins at neXtProt for PREP: NX_P48147

Explore proteomics data for PREP at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48147

  • 4/22 DME Specific Peptides for PREP (P48147) (see all 22)
     KQHFEWL  TKIPMFI  YGGFNIS  QDYHGHK 

    PREP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PREP Protein Expression
    REFSEQ proteins: NP_002717.3  
    ENSEMBL proteins: 
     ENSP00000358106   ENSP00000401796  

    Human Recombinant Protein Products for PREP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PREP (Prolyl Oligopeptidase/PREP)
    Enzo Life Sciences proteins for PREP
    OriGene Purified Protein for PREP
    OriGene Protein Over-expression Lysate for PREP
    OriGene MassSpec for PREP 
    OriGene Custom Protein Services for PREP
    GenScript Custom Purified and Recombinant Proteins Services for PREP
    Novus Biologicals PREP Proteins
    Novus Biologicals PREP Lysates
    Sino Biological Recombinant Protein for PREP
    Sino Biological Cell Lysate for PREP 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PREP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    PREP for ontologies           About GeneDecksing



    PREP Antibody Products: 
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    Novus Biologicals PREP Antibodies
    Abcam antibodies for PREP
    Cloud-Clone Corp. Antibodies for PREP 
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    LSBio Antibodies in human, mouse, rat for PREP 

    Assay Products for PREP: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PREP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PREP 
    Cloud-Clone Corp. CLIAs for PREP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001375 Peptidase_S9
     IPR004106 Peptidase_S9A_B_C_N
     IPR002471 Pept_S9_AS
     IPR002470 Peptidase_S9A
     IPR023302 Pept_S9A_oligopept_N

    Graphical View of Domain Structure for InterPro Entry P48147

    ProtoNet protein and cluster: P48147

    2 Blocks protein domains:
    IPB002470 Prolyl oligopeptidase serine protease (S9A) signature
    IPB002471 Prolyl endopeptidase


    UniProtKB/Swiss-Prot: PPCE_HUMAN, P48147
    Similarity: Belongs to the peptidase S9A family


    PREP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PPCE_HUMAN, P48147
    Function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to
    approximately 30 amino acids long
    Catalytic activity: Hydrolysis of Pro- -Xaa >> Ala- -Xaa in oligopeptides

         Genatlas biochemistry entry for PREP:
    prolyl oligopeptidase,alpha/beta hydrolase fold family

         Enzyme Number (IUBMB): EC 3.4.21.261 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008236serine-type peptidase activity TAS7959018
    GO:0070008serine-type exopeptidase activity IEA--
         
    PREP for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prep):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  nervous system  renal/urinary system 

    PREP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PREP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PREP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PREP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PREP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PREP
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PREP:
    hsa-miR-577 hsa-miR-3163 hsa-miR-513b hsa-miR-518a-5p hsa-miR-3143 hsa-miR-129-3p hsa-miR-3148 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidPREP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PREP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PREP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PREP
    Sirion Biotech Customized adenovirus for overexpression of PREP

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PREP (see all 7)
    OriGene ORF clones in mouse, rat for PREP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PREP (NM_002726)
    Sino Biological Human cDNA Clone for PREP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PREP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PREP
    Sirion Biotech Customized lentivirus for stable overexpression of PREP 
                         Customized lentivirus expression plasmids for stable overexpression of PREP 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PREP
    Search LifeMap BioReagents cell lines for PREP
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PREP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/10 Interacting proteins for PREP (P481473 ENSP000003581064) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    OXTP011783, ENSP000002173864I2D: score=1 STRING: ENSP00000217386
    KNG1P010423, ENSP000002650234I2D: score=1 STRING: ENSP00000265023
    NTSP309903, ENSP000002560104I2D: score=1 STRING: ENSP00000256010
    TAC1P203663, ENSP000003211064I2D: score=1 STRING: ENSP00000321106
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    PREP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PREP for compounds           About GeneDecksing

    EMD Millipore small molecules for PREP:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for PREP

    Browse Tocris compounds for PREP (PPCE)

    3 HMDB Compounds for PREP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arginine vasopressin 1-8Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg;Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg [Disulfide Bridge: 1-6];des-Gly-NH(,2)('9),[Arg('8)]-Vasopressin 37552-33-3--
    Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--
    Oxytocin 1-8Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu ----

    9 DrugBank Compounds for PREP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Hydroxy-1-Thio-Glycerol-- --target--17139284 17016423 10592235
    Double Oxidized Cysteine-- --target--17139284 17016423 10592235
    Monothioglycerol-- --target--17139284 17016423 10592235
    OxytocinPitocin (see all 2)50-56-6enzymesubstrate6361010 3544718 11495689
    S-Oxy Cysteine-- --target--17139284 17016423 10592235
    (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one-- --target--10592235
    1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one-- --target--10592235
    2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione-- --target--10592235
    Z-Pro-Prolinal-- --target--10592235

    10/33 Novoseek inferred chemical compound relationships for PREP gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poststatin 92.2 12 8931723 (3), 8931724 (2), 8968396 (2), 8931725 (2) (see all 6)
    z-pro-prolinal 91.1 10 16942854 (2), 1980725 (1), 18927208 (1), 20024801 (1) (see all 6)
    proline 75 43 15509157 (2), 8652620 (1), 8951032 (1), 15217351 (1) (see all 30)
    serine 72.2 70 9325271 (3), 9148758 (2), 1995635 (2), 7927537 (2) (see all 56)
    gluten 66.8 11 16206502 (2), 16136593 (1), 16690904 (1), 18836204 (1) (see all 8)
    thimet 63.3 2 9876288 (1), 9879742 (1)
    gliadin 56 7 15143130 (3), 14600421 (1), 16143118 (1), 16230098 (1) (see all 5)
    deae-cellulose 32.2 1 11137456 (1)
    tripeptide 25.4 2 8652620 (1), 2175370 (1)
    aprotinin 22.3 2 7588785 (2)

    Search CenterWatch for drugs/clinical trials and news about PREP / PPCE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PREP gene: 
    NM_002726.4  

    Unigene Cluster for PREP:

    Prolyl endopeptidase
    Hs.436564  [show with all ESTs]
    Unigene Representative Sequence: NM_002726
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369110(uc003prc.3) ENST00000448705

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PREP
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate PREP:
    hsa-miR-577 hsa-miR-3163 hsa-miR-513b hsa-miR-518a-5p hsa-miR-3143 hsa-miR-129-3p hsa-miR-3148 hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidPREP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PREP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PREP
    Clone
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    OriGene ORF clones in mouse, rat for PREP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PREP (NM_002726)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PREP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PREP
    Sirion Biotech Customized lentivirus for stable overexpression of PREP 
                         Customized lentivirus expression plasmids for stable overexpression of PREP 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PREP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PREP

    Additional mRNA sequence: 

    AB020018.1 AB028867.1 AK314195.1 AY660966.1 BC030636.2 D21102.1 X74496.1 

    7 DOTS entries:

    DT.100783673  DT.453965  DT.100000836  DT.121318525  DT.121318533  DT.97802437  DT.95179708 

    24/166 AceView cDNA sequences (see all 166):

    BU617058 AI888722 D25810 BQ889182 AA594106 BF724523 BU931903 BM828521 
    BM016994 CA307633 AA860678 CA308061 CD108093 CA306524 BU160369 BG698006 
    AW778949 BM791205 AA974681 AA338078 BG744822 BQ028398 CA430997 AA419493 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PREP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGACTT
    PREP Expression
    About this image


    See PREP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PREP

    SOURCE GeneReport for Unigene cluster: Hs.436564
        SABiosciences Custom PCR Arrays for PREP
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PREP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PREP gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prep1 , 5 prolyl endopeptidase1, 5 88.29(n)1
    95.91(a)1
      10 (23.27 cM)5
    190721  NM_011156.21  NP_035286.11 
     450672145 
    chicken
    (Gallus gallus)
    Aves PREP1 prolyl endopeptidase 81.1(n)
    90.41(a)
      421785  NM_001006410.1  NP_001006410.1 
    lizard
    (Anolis carolinensis)
    Reptilia PREP6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL343430.1(686187-773002)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144502 Xenopus laevis, Similar to prolyl endopeptidase, clone more 78.75(n)    BC047161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prep1 prolyl endopeptidase 70.2(n)
    76.13(a)
      553791  NM_001020753.1  NP_001018589.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG53553 prolyl oligopeptidase 53(a)
    (best of 2)
      31E1   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G761401 prolyl oligopeptidase-like protein 59.93(n)
    57.75(a)
      843946  NM_106263.4  NP_177741.3 
    rice
    (Oryza sativa)
    Liliopsida Os.155412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.84(n)    AK071405.1 


    ENSEMBL Gene Tree for PREP (if available)
    TreeFam Gene Tree for PREP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PREP gene
    PREPL2  

    PREP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2714 SNPs in PREP are shown (see all 2714)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs786521931,2
    --103257121(+) TTTTTT/AAAACA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs599028291,2
    C,F--105722656(+) TATGGA/TTGAAA 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs11493041,2
    C,F,A--105722716(-) AAAAAA/GAAAAG 1 -- ds50011Minor allele frequency- G:0.15WA 118
    rs1433893461,2
    C--105722729(+) TTTCC-/AGTA  
            
    AGTAA
    1 -- ds50010--------
    rs1463398881,2
    C--105722778(+) AGGAG-/AAAC  
            
    AAACA
    1 -- ds50010--------
    rs1398142701,2
    --105722824(+) TGCTTA/GGATAT 1 -- ds50010--------
    rs722502161,2
    C--105722837(+) GTATC-/TGTT  
            
    TGTTT
    1 -- ds50010--------
    rs1999098311,2
    --105722844(+) TTTGT-/TTGG  
            
    ATAAT
    1 -- ds50010--------
    rs1171858971,2
    F--105722858(+) TTACTC/TATGTG 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs596796541,2
    C,F--105722989(+) GGAGGC/GATCCA 1 -- ds50014Minor allele frequency- G:0.15NA CSA WA 242

    HapMap Linkage Disequilibrium report for PREP (105725440 - 105850999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PREP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv886530CNV Loss21882294
    nsv886529CNV Loss21882294
    esv28038CNV Loss19812545
    esv7369OTHER Inversion19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600400    OMIM disorders: --

    20/24 diseases for PREP (see all 24):    About MalaCards
    fibromyalgia    post-traumatic stress disorder    trypanosomiasis    celiac disease
    bulimia nervosa    bipolar disorder    otitis media    b-cell chronic lymphocytic leukemia
    anorexia nervosa    schizophrenia    osteoarthritis    alzheimer's disease
    dementia    neuroblastoma    chronic lymphocytic leukemia    multiple sclerosis
    renal cell carcinoma    rheumatoid arthritis    tuberculosis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for PREP:
    Amnestic disorder     Celiac disease

    PREP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/15 Novoseek inferred disease relationships for PREP gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celiac disease 65.9 10 16206502 (2), 16143118 (2), 18836204 (2), 16136593 (1) (see all 7)
    memory disorders 50.8 3 12202494 (1), 12228249 (1), 10747969 (1)
    amnesia 43.5 2 15713471 (1), 11915948 (1)
    trypanosomiasis 40.8 1 11915948 (1)
    alzheimers disease 34.3 5 16187206 (1), 11711876 (1), 17703733 (1), 16390203 (1) (see all 5)
    bipolar disorder 28 1 19593439 (1)
    neurodegenerative diseases 22.1 2 16092940 (1), 16086671 (1)
    schizophrenia 13.5 3 10363664 (1), 19593439 (1), 9802123 (1)
    major depression 9.3 5 8038298 (2), 8570777 (1), 9802123 (1)
    fibromyalgia 3.97 3 9723150 (2), 11543693 (1)

    Genetic Association Database (GAD): PREP
    Human Genome Epidemiology (HuGE) Navigator: PREP (11 documents)

    Export disorders for PREP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PREP gene, integrated from 9 sources (see all 245):
    (articles sorted by number of sources associating them with PREP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. (PubMed id 7959018)1, 2, 3, 9 Vanhoof G.... Scharpe S. (1994)
    2. The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family. (PubMed id 7588785)1, 2, 9 Goossens F....Scharpe S. (1995)
    3. Molecular cloning and characterization of prolyl endopeptidase from human T cells. (PubMed id 8089089)1, 2, 9 Shirasawa Y.... Hirashima A. (1994)
    4. No association between the PREP gene and lithium responsive bipolar disorder. (PubMed id 17324276)1, 4, 9 Mamdani F....Turecki G. (2007)
    5. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Genome-wide linkage scans for type 2 diabetes mellitu s in four ethnically diverse populations-significant evidence for linkage on ch romosome 4q in African Americans: the Family Investigation of Nephropathy and D iabetes Research Group. (PubMed id 19795399)1, 4 Malhotra A....Hanson R.L. (2009)
    8. Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. (PubMed id 16092940)1, 9 Schulz I....Rossner S. (2005)
    9. Distribution of prolyl endopeptidase activities in rat and human brain. (PubMed id 11792464)1, 9 Irazusta J....Casis L. (2002)
    10. Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. (PubMed id 15380924)1, 9 Valdivia A....Casis L. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5550 HGNC: 9358 AceView: PREP Ensembl:ENSG00000085377 euGenes: HUgn5550
    ECgene: PREP H-InvDB: PREP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PREP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PREP gene:
    Search GeneIP for patents involving PREP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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