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PRELP Gene

protein-coding   GIFtS: 60
GCID: GC01P203444

Proline/Arginine-Rich End Leucine-Rich Repeat Protein

(Previous name: proline arginine-rich end leucine-rich repeat protein)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proline/Arginine-Rich End Leucine-Rich Repeat Protein1 2     55 KDa Leucine-Rich Repeat Protein Of Articular Cartilage2
Prolargin Proteoglycan1 2     MST1612
Proline-Arginine-Rich End Leucine-Rich Repeat Protein2 3     MSTP1612
SLRR2A2 3     prolargin2
Proline Arginine-Rich End Leucine-Rich Repeat Protein1     

External Ids:    HGNC: 93571   Entrez Gene: 55492   Ensembl: ENSG000001887837   OMIM: 6019145   UniProtKB: P518883   

Export aliases for PRELP gene to outside databases

Previous GC identifers: GC01M201269 GC01M199012 GC01P9D0034 GC00P9S0034 GC01P200176 GC01P201711 GC01P174609


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRELP Gene:
The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular
matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue.
This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It
also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved
in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in
basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been
observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRELP Gene:
PRELP (proline/arginine-rich end leucine-rich repeat protein) is a protein-coding gene. Diseases associated with PRELP include progeria, and morquio syndrome b. GO annotations related to this gene include extracellular matrix structural constituent and heparin binding. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888
Function: May anchor basement membranes to the underlying connective tissue (By similarity)

Gene Wiki entry for PRELP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRELP gene promoter:
         GR   SREBP-1c   Pax-2   Pax-2a   SREBP-1b   PPAR-alpha   Pax-2b   SREBP-1a   FOXO4   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRELP promoter sequence
   Search Chromatin IP Primers for PRELP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRELP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32

PRELP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRELP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P203444:  view genomic region     (about GC identifiers)

Start:
203,444,883 bp from pter      End:
203,460,480 bp from pter
Size:
15,598 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888 (See protein sequence)
Recommended Name: Prolargin precursor  
Size: 382 amino acids; 43810 Da
Subunit: Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and
type II (By similarity)
Secondary accessions: Q6FG38

Explore the universe of human proteins at neXtProt for PRELP: NX_P51888

Explore proteomics data for PRELP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn124, Asn289, Asn320, Asn327

  • See PRELP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002716.1  NP_958505.1  

    ENSEMBL proteins: 
     ENSP00000343924  
    Reactome Protein details: P51888

    PRELP Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR027216 Prolargin
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry P51888

    ProtoNet protein and cluster: P51888

    1 Blocks protein domain: IPB000372 Cysteine-rich flanking region

    UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888
    Domain: The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and
    type II through its leucine-rich repeat domain (By similarity)
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily
    Similarity: Contains 12 LRR (leucine-rich) repeats


    PRELP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRELP_HUMAN, P51888
    Function: May anchor basement membranes to the underlying connective tissue (By similarity)

         Genatlas biochemistry entry for PRELP:
    prolargine,proline/arginine rich and leucine-rich repeat protein,matrix protein of articular cartilage,55 kDa,with
    three alternatively spliced forms,expressed in adult chondrocytes and lung

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent IEA--
    GO:0005515protein binding ----
    GO:0008201heparin binding IEA--
         
    PRELP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRELP:
     Decreased POU5F1-GFP protein e 

         1 MGI phenotypic allele for Prelp (no phenotypes)

    PRELP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRELP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRELP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRELP

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PRELP (see all 29):
    hsa-miR-217 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-185* hsa-miR-15a hsa-miR-3167 hsa-miR-1297 hsa-miR-4314
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRELP (NM_002725)
    Sino Biological Human cDNA Clone for PRELP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRELP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRELP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRELP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRELP_HUMAN, P51888: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    lysosome4
    vacuole4
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005796Golgi lumen TAS--
    GO:0031012colocalizes with extracellular matrix ISS--
    GO:0043202lysosomal lumen TAS--

    PRELP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRELP About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Keratan sulfate/keratin metabolism
    Keratan sulfate/keratin metabolism0.85
    Keratan sulfate degradation0.00
    Keratan sulfate biosynthesis0.85
    3Metabolism
    Metabolism0.38
    4Disease
    Disease
    5Articular Cartilage Extracellular Matrix
    Articular Cartilage Extracellular Matrix

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for PRELP
        Articular Cartilage Extracellular Matrix



    2 Reactome Pathways for PRELP
        Keratan sulfate biosynthesis
    Keratan sulfate degradation



    PRELP for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRELP
    Interactions:

        GeneGlobe Interaction Network for PRELP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRELP (P518882, 3 ENSP000003439244) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    FBLN2P980953, ENSP000003841694I2D: score=3 STRING: ENSP00000384169
    HSPG2P981603, ENSP000003638274I2D: score=3 STRING: ENSP00000363827
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    NID1P145433, ENSP000002641874I2D: score=1 STRING: ENSP00000264187
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS7592739
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007569cell aging IEA--
    GO:0018146keratan sulfate biosynthetic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    PRELP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRELP

    5 Novoseek inferred chemical compound relationships for PRELP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 68 10 11007795 (3), 12437997 (1), 18973232 (1), 11731272 (1) (see all 8)
    keratan sulfate 65.3 2 17093390 (1)
    heparan sulfate 42.5 7 11007795 (3), 11847210 (3)
    arginine 26.4 4 11007795 (3), 11731272 (1)
    heparin 26.1 10 11007795 (6), 19700767 (1)



    PRELP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRELP gene (2 alternative transcripts): 
    NM_002725.3  NM_201348.1  

    Unigene Cluster for PRELP:

    Proline/arginine-rich end leucine-rich repeat protein
    Hs.632481  [show with all ESTs]
    Unigene Representative Sequence: NM_002725
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343110(uc001gzs.3 uc001gzt.3)
    miRNA
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    hsa-miR-217 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-185* hsa-miR-15a hsa-miR-3167 hsa-miR-1297 hsa-miR-4314
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    Additional mRNA sequence: 

    AK098245.1 BC032498.1 CR541787.1 CR542270.1 U29089.1 

    9 DOTS entries:

    DT.317136  DT.99950351  DT.455267  DT.99941703  DT.99951930  DT.97792915  DT.97839552  DT.40314367 
    DT.95167576 

    Selected AceView cDNA sequences (see all 420):

    CD615469 BQ640546 BG697476 BQ007787 BQ708764 CB163542 BQ045074 BQ181964 
    AI242047 AI889731 NM_002725 AI686677 BQ182271 AA612620 AI420190 CA394261 
    NM_201348 BQ029123 BC032498 BI766111 BQ183782 BQ072552 BI753476 CR541787 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PRELP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for PRELP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRELP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGCTTCC
    PRELP Expression
    About this image


    PRELP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Growth Plate
             Articular chondrocyte-like cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocytes Zeugopod Epiphyseal End
             Articular chondrocyte-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    PRELP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRELP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632481

    UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888
    Tissue specificity: Connective tissue

        Custom PCR Arrays for PRELP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRELP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PRELP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prelp1 , 5 proline arginine-rich end leucine-rich repeat1, 5 88.23(n)1
    92.88(a)1
      1 (58.02 cM)5
    1168471  NM_054077.41  NP_473418.31 
     1339103045 
    chicken
    (Gallus gallus)
    Aves PRELP1 proline/arginine-rich end leucine-rich repeat protein 79.24(n)
    79.64(a)
      419933  XM_418054.4  XP_418054.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRELP6
    proline/arginine-rich end leucine-rich repeat prot...
    72(a)
    1 ↔ 1
    4(118598704-118628063)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prelp1 proline/arginine-rich end leucine-rich repeat protein 66.37(n)
    69.64(a)
      100124759  NM_001102738.1  NP_001096208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prelp1 proline/arginine-rich end leucine-rich repeat protein 65.74(n)
    62.46(a)
      100144408  XM_001923555.4  XP_001923590.1 


    ENSEMBL Gene Tree for PRELP (if available)
    TreeFam Gene Tree for PRELP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRELP gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  FLRT32  OMD2  ASPN2  
    BGN2  DCN2  FLRT22  ECM22  LOC1005090912  LUM2  
    6 SIMAP similar genes for PRELP using alignment to 2 protein entries:     PRELP_HUMAN (see all proteins):
    MST161    KERA    LUM    OMD    FMOD    DCN

    PRELP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRELP (see all 456)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727436181,2
    C,F--203442887(+) TCTCAC/GCTCAG 2 -- us2k13Minor allele frequency- G:0.09CSA WA 121
    rs1414156111,2
    --203442994(+) GTCTCA/GAACTC 2 -- us2k10--------
    rs1867452651,2
    --203443021(+) TTCTGC/TCTTCG 2 -- us2k10--------
    rs1900265211,2
    --203443025(+) GCCTTC/TGTCTC 2 -- us2k10--------
    rs1153960541,2
    F--203443026(+) CCTTCG/ATCTCC 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1839557801,2
    --203443034(+) TCCCAC/TAGTGC 2 -- us2k10--------
    rs1140982331,2
    C,F--203443192(+) AAGCAC/TATGAG 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1503848571,2
    --203443274(+) CAGGGC/GGTGAA 2 -- us2k10--------
    rs37536371,2
    C,F,H--203443275(-) CTTCAC/TGCCCT 2 -- us2k15Minor allele frequency- T:0.01EA NS 1892
    rs1495020371,2
    C--203443347(+) TTTCTC/TAGGCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRELP (203444883 - 203460480 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PRELP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRELP
    DNA2.0 Custom Variant and Variant Library Synthesis for PRELP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601914    OMIM disorders: --

    14 diseases for PRELP:    
    About MalaCards
    progeria    morquio syndrome b    sly syndrome    mucopolysaccharidoses
    myopia    choroiditis    essential hypertension    osteoarthritis
    hypertension    rheumatoid arthritis    arthritis    pancreatitis
    hepatitis    neuronitis


    PRELP for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRELP
    Human Genome Epidemiology (HuGE) Navigator: PRELP (2 documents)

    Export disorders for PRELP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRELP gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with PRELP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene organization, chromosome location, and expression of a 55- kDa matrix protein (PRELP) of human articular cartilage. (PubMed id 8954791)1, 2, 9 Grover J.... Roughley P.J. (Genomics 1996)
    2. The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. (PubMed id 7592739)1, 2, 9 Bengtsson E.... Sommarin Y. (J. Biol. Chem. 1995)
    3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. (PubMed id 17093390)1, 9 Johnson J.M....Rada J.A. (Mol. Vis. 2006)
    7. The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. (PubMed id 11847210)1, 9 Bengtsson E....Aspberg A. (J. Biol. Chem. 2002)
    8. PRELP, collagen, and a theory of Hutchinson-Gilford progeria. (PubMed id 12437997)1, 9 Lewis M. (Ageing Res. Rev. 2003)
    9. The consequence of PRELP overexpression on skin. (PubMed id 17123807)1, 9 Grover J....Roughley P.J. (Matrix Biol. 2007)
    10. Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element. (PubMed id 9806887)1, 9 Grover J. and Roughley P.J. (Biochem. J. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5549 HGNC: 9357 AceView: PRELP Ensembl:ENSG00000188783 euGenes: HUgn5549
    ECgene: PRELP H-InvDB: PRELP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRELP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRELP gene:
    Search GeneIP for patents involving PRELP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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