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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRELP Gene

protein-coding GIFtS: 60
GCID: GC01P203444

proline/arginine-rich end leucine-rich repeat protein

(Previous name: proline arginine-rich end leucine-rich repeat protein )

Explore 8 diseases affiliated with
PRELP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Proline/Arginine-Rich End Leucine-Rich Repeat Protein¹ ²		55 KDa Leucine-Rich Repeat Protein Of Articular Cartilage²
SLRR2A¹ ² ³		MST161²
Prolargin¹		MSTP161²
Proline-Arginine-Rich End Leucine-Rich Repeat Protein² ³		Prolargin Proteoglycan²
Proline Arginine-Rich End Leucine-Rich Repeat Protein¹

External Ids:	HGNC: 9357¹	Entrez Gene: 5549²	Ensembl: ENSG00000188783⁷	OMIM: 601914⁵	UniProtKB: P51888³

Export aliases for PRELP gene to outside databases

Previous GC identifers: GC01M201269 GC01M199012 GC01P9D0034 GC00P9S0034 GC01P200176 GC01P201711 GC01P174609

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRELP:

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix.

This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein

has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the

basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis

of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and

cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888

Function: May anchor basement membranes to the underlying connective tissue (By similarity)

Gene Wiki entry for PRELP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRELP gene promoter:
GR SREBP-1c Pax-2 Pax-2a SREBP-1b PPAR-alpha Pax-2b SREBP-1a FOXO4 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRELP promoter sequence

Search SABiosciences Chromatin IP Primers for PRELP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRELP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32

PRELP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRELP gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P203444: view genomic region (about GC identifiers)

Start:	203,444,883 bp from pter	End:	203,460,480 bp from pter
Size:	15,598 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888 (See protein sequence)

Recommended Name: Prolargin precursor

Size: 382 amino acids; 43810 Da

Subunit: Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type

II (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q6FG38

Explore the universe of human proteins at neXtProt for PRELP: NX_P51888

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51888

PRELP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002716.1 NP_958505.1

ENSEMBL proteins:

ENSP00000343924

Reactome Protein details: P51888
Human Recombinant Protein Products:

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	Uscn Proteins for PRELP

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005796	Golgi lumen	TAS	--
GO:0031012	colocalizes with extracellular matrix	ISS	--
GO:0043202	lysosomal lumen	TAS	--

PRELP for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRELP for domains About GeneDecksing

3 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR027216 Prolargin

IPR000372 LRR-contain_N

Graphical View of Domain Structure for InterPro Entry P51888

ProtoNet protein and cluster: P51888

1 Blocks protein family: IPB000372 Cysteine-rich flanking region

UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888

Domain: The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and type II

through its leucine-rich repeat domain (By similarity)

Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily

Similarity: Contains 12 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888

Function: May anchor basement membranes to the underlying connective tissue (By similarity)

Genatlas biochemistry entry for PRELP:

prolargine,proline/arginine rich and leucine-rich repeat protein,matrix protein of articular cartilage,55 kDa,with

three alternatively spliced forms,expressed in adult chondrocytes and lung

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		hsa-miR-217 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-185* hsa-miR-15a hsa-miR-3167 hsa-miR-1297 hsa-miR-4314

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRELP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	TAS	7592739
GO:0008201	heparin binding	IEA	--

PRELP for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for PRELP:

Decreased POU5F1-GFP protein e

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/14 pathways (see all 14)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIIA - Sanfilippo syndrome A	1.00
MPS I - Hurler syndrome	1.00	MPS IIID - Sanfilippo syndrome D	1.00
Mucopolysaccharidoses	1.00	MPS IX - Natowicz syndrome	1.00
MPS IV - Morquio syndrome A	1.00	MPS II - Hunter syndrome	1.00

Extracellular KSPG translocates to the lysosome for degradation

	Extracellular KSPG translocates to the lysosome for degradation	1.00			Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase	1.00
	KSPG is secreted from the cell	1.00			Keratan sulfate degradation	0.58

Keratan sulfate biosynthesis

Keratan sulfate biosynthesis

1.00

Keratan sulfate/keratin metabolism

0.84

Disease

Disease

1.00

Metabolism

Metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for PRELP

Articular Cartilage Extracellular Matrix

5/22 Reactome Pathways for PRELP (see all 22)

	MPS VI - Maroteaux-Lamy syndrome
	Metabolism
	Disease
	Keratan sulfate/keratin metabolism
	MPS IIIA - Sanfilippo syndrome A

PRELP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRELP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for PRELP (P51888^{2, 3} ENSP00000343924⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=3 STRING: ENSP00000225964
FBLN2	P98095³, ENSP00000384169⁴	I2D: score=3 STRING: ENSP00000384169
HSPG2	P98160³, ENSP00000363827⁴	I2D: score=3 STRING: ENSP00000363827
FN1	P02751³, ENSP00000346839⁴	I2D: score=2 STRING: ENSP00000346839
NID1	P14543³, ENSP00000264187⁴	I2D: score=1 STRING: ENSP00000264187

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	7592739
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0007569	cell aging	IEA	--
GO:0018146	keratan sulfate biosynthetic process	TAS	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--

PRELP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRELP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRELP
5 Novoseek chemical compound relationships for PRELP gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
proline	68	10	11007795 (3), 12437997 (1), 18973232 (1), 11731272 (1) (see all 8)
keratan sulfate	65.3	2	17093390 (1)
heparan sulfate	42.5	7	11007795 (3), 11847210 (3)
arginine	26.4	4	11007795 (3), 11731272 (1)
heparin	26.1	10	11007795 (6), 19700767 (1)

Search CenterWatch for drugs/clinical trials and news about PRELP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRELP gene (2 alternative transcripts):

NM_002725.3 NM_201348.1

Unigene Cluster for PRELP:

Proline/arginine-rich end leucine-rich repeat protein

Hs.632481 [show with all ESTs]

Unigene Representative Sequence: NM_002725

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000343110(uc001gzs.3 uc001gzt.3)

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		hsa-miR-217 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-185* hsa-miR-15a hsa-miR-3167 hsa-miR-1297 hsa-miR-4314

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Additional cDNA sequence:

AK098245.1 BC032498.1 CR541787.1 CR542270.1 U29089.1

9 DOTS entries:

DT.317136 DT.99950351 DT.455267 DT.99941703 DT.99951930 DT.97792915 DT.97839552 DT.40314367

DT.95167576

24/420 AceView cDNA sequences (see all 420):

BU625097 CD615469 BQ181603 BQ004427 CD519293 BQ708764 CA441731 BQ181828

CA393630 AI686677 BU728219 CR541787 BM664220 BM710261 BQ180849 BQ182135

BQ007627 AA131664 BQ181964 W02703 T63291 N43001 CD514511 BQ008793

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for PRELP About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3
SP1:
SP2:					-

ECgene alternative splicing isoforms for PRELP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRELP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTGCTTCC

About this image

PRELP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Bone

Zeugopod Epiphyseal End

Bone

Zeugopod Growth Plate

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Articular chondrocyte-like cells (HyStem chondrogenic ...)

Cartilage

HyStem+BMP4-induced 4D20.8 cells (Chondrogenic inducti...)

Bone, Cartilage

See PRELP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRELP

SOURCE GeneReport for Unigene cluster: Hs.632481

UniProtKB/Swiss-Prot: PRELP_HUMAN, P51888

Tissue specificity: Connective tissue

SABiosciences Custom PCR Arrays for PRELP

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRELP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PRELP gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRELP¹	proline/arginine-rich end leucine-rich repeat protein	76.91(n) 76.28(a)		419933 XM_418054.3 XP_418054.2
lizard (Anolis carolinensis)	Reptilia	PRELP⁶	--	71(a)	1 ↔ 1	4(118598704-118605396)
zebrafish (Danio rerio)	Actinopterygii	prelp¹	proline/arginine-rich end leucine-rich repeat protein	63.23(n) 59.62(a)		100144408 XM_001923555.3 XP_001923590.1

ENSEMBL Gene Tree for PRELP (if available)
TreeFam Gene Tree for PRELP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRELP gene

OGN² OPTC² PODN² PODNL1² FMOD² KERA² ASPN² OMD²

BGN² DCN² EPYC² ECM2² LUM²

6 SIMAP similar genes for PRELP using alignment to 2 protein entries: PRELP_HUMAN (see all proteins):

MST161 KERA LUM OMD FMOD DCN

PRELP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72743618^1,2	C,	--	203442887(+)	`TCTCAC/GCTCAG`	2	--	us2k¹		3		CSA WA	121
rs141415611^1,2		--	203442994(+)	`GTCTCA/GAACTC`	2	--	us2k¹		0	--	--	--	--
rs186745265^1,2		--	203443021(+)	`TTCTGC/TCTTCG`	2	--	us2k¹		0	--	--	--	--
rs190026521^1,2		--	203443025(+)	`GCCTTC/TGTCTC`	2	--	us2k¹		0	--	--	--	--
rs115396054^1,2		--	203443026(+)	`CCTTCG/ATCTCC`	2	--	us2k¹		1		NA	120
rs183955780^1,2		--	203443034(+)	`TCCCAC/TAGTGC`	2	--	us2k¹		0	--	--	--	--
rs114098233^1,2		--	203443192(+)	`AAGCAC/TATGAG`	2	--	us2k¹		1		NA	120
rs150384857^1,2		--	203443274(+)	`CAGGGC/GGTGAA`	2	--	us2k¹		0	--	--	--	--
rs3753637^1,2	C,F,H,	--	203443275(-)	`CTTCAC/TGCCCT`	2	--	us2k¹		5		EA NS	1892
rs149502037^1,2		--	203443347(+)	`TTTCTC/TAGGCT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PRELP (203444883 - 203460480 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRELP: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRELP

DNA2.0 Custom Variant and Variant Library Synthesis for PRELP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRELP for disorders           About GeneDecksing

OMIM gene information: 601914    OMIM disorders: --

8 diseases for PRELP:    About MalaCards

progeria essential hypertension rheumatoid arthritis myopia

hypertension choroiditis osteoarthritis arthritis

Human Genome Epidemiology (HuGE) Navigator: PRELP (2 documents)

Export disorders for PRELP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PRELP gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with PRELP)

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The gene organization, chromosome location, and expression of a 55- kDa matrix protein (PRELP) of human articular cartilage. (PubMed id 8954791)^{1, 2, 9} Grover J.... Roughley P.J. (1996)
The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissues. (PubMed id 7592739)^{1, 2, 9} Bengtsson E.... Sommarin Y. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. (PubMed id 17093390)^{1, 9} Johnson J.M....Rada J.A. (2006)
The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. (PubMed id 11847210)^{1, 9} Bengtsson E....Aspberg A. (2002)
PRELP, collagen, and a theory of Hutchinson-Gilford progeria. (PubMed id 12437997)^{1, 9} Lewis M. (2003)
The consequence of PRELP overexpression on skin. (PubMed id 17123807)^{1, 9} Grover J....Roughley P.J. (2007)
Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element. (PubMed id 9806887)^{1, 9} Grover J. and Roughley P.J. (1998)
PRELP protein inhibits the formation of the complement membrane attack complex. (PubMed id 22267731)¹ Happonen K.E....Blom A.M. (2012)
Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)¹ Joslyn G....White R.L. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5549	HGNC: 9357	AceView: PRELP	Ensembl:ENSG00000188783	euGenes: HUgn5549
ECgene: PRELP	H-InvDB: PRELP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PRELP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PRELP gene
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Patent Information for PRELP gene:
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proline/arginine-rich end leucine-rich repeat protein

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proline/arginine-rich end leucine-rich repeat protein

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