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Aliases for PRELID3B Gene

Aliases for PRELID3B Gene

  • PRELI Domain Containing 3B 2 3 5
  • Protein Slowmo Homolog 2 3 4
  • C20orf45 3 4
  • SLMO2 3 4
  • Chromosome 20 Open Reading Frame 45 2
  • PRELI Domain Containing Protein 3B 3
  • Slowmo Homolog 2 (Drosophila) 2
  • Slowmo Homolog 2 3
  • DJ543J19.5 3

External Ids for PRELID3B Gene

Previous HGNC Symbols for PRELID3B Gene

  • C20orf45
  • SLMO2

Summaries for PRELID3B Gene

GeneCards Summary for PRELID3B Gene

PRELID3B (PRELI Domain Containing 3B) is a Protein Coding gene. An important paralog of this gene is PRELID3A.

Additional gene information for PRELID3B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRELID3B Gene

Genomics for PRELID3B Gene

Regulatory Elements for PRELID3B Gene

Enhancers for PRELID3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H059010 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +31.8 31750 2.1 HDGF PKNOX1 ATF1 MLX ARID4B TCF12 ZNF766 GATA2 ELK1 SP5 NELFCD LOC101927932 PRELID3B GNAS ENSG00000268649 CTSZ TUBB1
GH20H059016 1.5 Ensembl ENCODE dbSUPER 17.9 +25.8 25844 1.7 FOXA2 MLX ZFP64 ARID4B DMAP1 SLC30A9 FOS SP5 MIER2 PPARG PRELID3B TUBB1 CTSZ
GH20H059014 1.2 Ensembl ENCODE dbSUPER 17.6 +28.4 28436 0.9 HDGF TAL1 ZNF175 TCF12 CTBP1 GATA3 GATA2 NCOR1 FOS MAFK NELFCD PRELID3B TUBB1 CTSZ
GH20H059012 1.3 ENCODE dbSUPER 11.5 +30.5 30450 0.4 HDGF ATF1 MLX ARID4B DMAP1 ZNF766 GATA2 ELK1 CAVIN1 SP5 LOC101927932 NELFCD PRELID3B ENSG00000268649 TUBB1 CTSZ
GH20H059030 1.1 ENCODE 10.4 +10.7 10722 2.5 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF766 NELFCD LOC101927932 PRELID3B ENSG00000268649 ATP5E TUBB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRELID3B on UCSC Golden Path with GeneCards custom track

Promoters for PRELID3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139465 409 1401 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF207 ZNF143

Genomic Locations for PRELID3B Gene

Genomic Locations for PRELID3B Gene
chr20:59,033,145-59,042,909
(GRCh38/hg38)
Size:
9,765 bases
Orientation:
Minus strand
chr20:57,608,200-57,617,964
(GRCh37/hg19)

Genomic View for PRELID3B Gene

Genes around PRELID3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRELID3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRELID3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRELID3B Gene

Proteins for PRELID3B Gene

  • Protein details for PRELID3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B1-PLD3B_HUMAN
    Recommended name:
    PRELI domain containing protein 3B
    Protein Accession:
    Q9Y3B1
    Secondary Accessions:
    • E1P5I8
    • Q5JX17
    • Q9NUL0

    Protein attributes for PRELID3B Gene

    Size:
    194 amino acids
    Molecular mass:
    21495 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34102.1; Type=Frameshift; Positions=192; Evidence={ECO:0000305};

    Alternative splice isoforms for PRELID3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRELID3B Gene

Post-translational modifications for PRELID3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRELID3B Gene

No data available for DME Specific Peptides for PRELID3B Gene

Domains & Families for PRELID3B Gene

Gene Families for PRELID3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRELID3B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRELID3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3B1

UniProtKB/Swiss-Prot:

PLD3B_HUMAN :
  • Belongs to the slowmo family.
Family:
  • Belongs to the slowmo family.
genes like me logo Genes that share domains with PRELID3B: view

Function for PRELID3B Gene

Phenotypes From GWAS Catalog for PRELID3B Gene

Gene Ontology (GO) - Molecular Function for PRELID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990050 phosphatidic acid transporter activity IBA --
genes like me logo Genes that share ontologies with PRELID3B: view

Phenotypes for PRELID3B Gene

genes like me logo Genes that share phenotypes with PRELID3B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRELID3B Gene

Localization for PRELID3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRELID3B gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRELID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005758 mitochondrial intermembrane space IBA --
genes like me logo Genes that share ontologies with PRELID3B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRELID3B Gene

Pathways & Interactions for PRELID3B Gene

SuperPathways for PRELID3B Gene

No Data Available

Interacting Proteins for PRELID3B Gene

Gene Ontology (GO) - Biological Process for PRELID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015914 phospholipid transport IEA --
genes like me logo Genes that share ontologies with PRELID3B: view

No data available for Pathways by source and SIGNOR curated interactions for PRELID3B Gene

Drugs & Compounds for PRELID3B Gene

No Compound Related Data Available

Transcripts for PRELID3B Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRELID3B Gene

No ASD Table

Relevant External Links for PRELID3B Gene

GeneLoc Exon Structure for
PRELID3B
ECgene alternative splicing isoforms for
PRELID3B

Expression for PRELID3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PRELID3B Gene:

PRELID3B

Evidence on tissue expression from TISSUES for PRELID3B Gene

  • Eye(4.4)
  • Nervous system(4)
  • Intestine(3)
  • Lung(2.9)
  • Liver(2.7)
  • Kidney(2.5)
  • Pancreas(2.3)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with PRELID3B: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRELID3B Gene

Orthologs for PRELID3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRELID3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLMO2 33 34
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia SLMO2 33 34
  • 93.13 (n)
dog
(Canis familiaris)
Mammalia SLMO2 33 34
  • 93.13 (n)
oppossum
(Monodelphis domestica)
Mammalia SLMO2 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLMO2 34
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slmo2 33 34
  • 86.49 (n)
Prelid3b 16
rat
(Rattus norvegicus)
Mammalia Slmo2 33
  • 86.49 (n)
chicken
(Gallus gallus)
Aves SLMO2 33 34
  • 80.58 (n)
lizard
(Anolis carolinensis)
Reptilia SLMO2 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.67 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14591 33
zebrafish
(Danio rerio)
Actinopterygii slmo2 33 34
  • 69.31 (n)
wufd54c05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4391 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008027 33
  • 54.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta slmo 33 34
  • 52.08 (n)
worm
(Caenorhabditis elegans)
Secernentea F15D3.6 33 34
  • 52.79 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL126C 33
  • 45.51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UPS3 34
  • 30 (a)
ManyToMany
UPS2 34 36
  • 26 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G13070 33
  • 46.83 (n)
rice
(Oryza sativa)
Liliopsida Os02g0717900 33
  • 40.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.655 34
  • 33 (a)
OneToMany
Species where no ortholog for PRELID3B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRELID3B Gene

ENSEMBL:
Gene Tree for PRELID3B (if available)
TreeFam:
Gene Tree for PRELID3B (if available)

Paralogs for PRELID3B Gene

Variants for PRELID3B Gene

Sequence variations from dbSNP and Humsavar for PRELID3B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000268181 -- 59,042,990(+) ACGGC(-/A)GCTGG upstream-variant-2KB
rs1000503107 -- 59,042,984(+) CCGCC(C/G)ACGGC upstream-variant-2KB
rs1001054057 -- 59,035,896(+) TAACA(A/G)TGCAT intron-variant
rs1001106539 -- 59,036,242(+) AAAAA(C/T)GGGAA intron-variant
rs1001621578 -- 59,039,871(+) ATTCT(A/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRELID3B Gene

Variant ID Type Subtype PubMed ID
nsv965894 CNV duplication 23825009

Variation tolerance for PRELID3B Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRELID3B Gene

Human Gene Mutation Database (HGMD)
PRELID3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRELID3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRELID3B Gene

Disorders for PRELID3B Gene

Relevant External Links for PRELID3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRELID3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRELID3B

No disorders were found for PRELID3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRELID3B Gene

Publications for PRELID3B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for PRELID3B Gene

Sources for PRELID3B Gene

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