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Aliases for PRELID3A Gene

Aliases for PRELID3A Gene

  • PRELI Domain Containing 3A 2 3 5
  • Erythroid Differentiation And Denucleation Factor 1 2 3
  • Protein Slowmo Homolog 1 3 4
  • C18orf43 3 4
  • SLMO1 3 4
  • Chromosome 18 Open Reading Frame 43 2
  • PRELI Domain Containing Protein 3A 3
  • Slowmo Homolog 1 (Drosophila) 2
  • Slowmo Homolog 1 3
  • HFL-EDDG1 3

External Ids for PRELID3A Gene

Previous HGNC Symbols for PRELID3A Gene

  • C18orf43
  • SLMO1

Previous GeneCards Identifiers for PRELID3A Gene

  • GC18P012412

Summaries for PRELID3A Gene

GeneCards Summary for PRELID3A Gene

PRELID3A (PRELI Domain Containing 3A) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Death Genes. An important paralog of this gene is PRELID3B.

UniProtKB/Swiss-Prot for PRELID3A Gene

  • In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRELID3A Gene

Genomics for PRELID3A Gene

Regulatory Elements for PRELID3A Gene

Enhancers for PRELID3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F012605 1.6 FANTOM5 Ensembl ENCODE 20.9 +199.7 199679 3.7 ELF3 TBP PKNOX1 SIN3A RAD21 RFX5 ZNF335 ZNF366 FOS ZNF362 SPIRE1 PRELID3A ENSG00000267199 RNU7-129P AFG3L2 PSMG2 CEP76 PTPN2 GC18P012513
GH18F012989 1.2 ENCODE 21.1 +583.3 583259 3.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 CEP192 PRELID3A ENSG00000267199 ENSG00000266969 HMGB3P28 SEH1L GC18P012986
GH18F012306 1.4 FANTOM5 ENCODE 15 -99.2 -99240 5.2 ATF1 CREB3L1 SIN3A DMAP1 ZNF48 ZNF766 GLIS2 ZNF143 KLF7 FOS TUBB6 PRELID3A AFG3L2 RNU7-129P CHMP1B
GH18F012402 1.2 Ensembl ENCODE 14.7 -4.3 -4270 2.1 HDAC1 PKNOX1 ATF1 ARNT CREB3L1 KLF17 ZBTB40 RFX5 ZNF335 GTF3C2 ENSG00000267199 ENSG00000267249 PRELID3A CEP76 RNU7-129P
GH18F012516 0.7 Ensembl 23.9 +108.4 108405 0.2 HDAC1 RNF2 CEBPB ELF1 GABPA FOXK2 HMBOX1 CREM SPI1 SP7 PRELID3A RNU7-129P AFG3L2 GC18P012513 PSMG2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRELID3A on UCSC Golden Path with GeneCards custom track

Promoters for PRELID3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000113605 304 2001 ATF1 CREB3L1 SIN3A FEZF1 GLI4 GLIS2 ZNF143 ZNF207 KLF13 ZNF263

Genomic Location for PRELID3A Gene

Chromosome:
18
Start:
12,407,896 bp from pter
End:
12,432,238 bp from pter
Size:
24,343 bases
Orientation:
Plus strand

Genomic View for PRELID3A Gene

Genes around PRELID3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRELID3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRELID3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRELID3A Gene

Proteins for PRELID3A Gene

  • Protein details for PRELID3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N28-PLD3A_HUMAN
    Recommended name:
    PRELI domain containing protein 3A
    Protein Accession:
    Q96N28
    Secondary Accessions:
    • B0YJ10
    • B4E0C9
    • D3DUJ1
    • Q6AHX2

    Protein attributes for PRELID3A Gene

    Size:
    172 amino acids
    Molecular mass:
    19247 Da
    Quaternary structure:
    • Interacts with TRIAP1.

    Three dimensional structures from OCA and Proteopedia for PRELID3A Gene

    Alternative splice isoforms for PRELID3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRELID3A Gene

Post-translational modifications for PRELID3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRELID3A Gene

Domains & Families for PRELID3A Gene

Gene Families for PRELID3A Gene

Protein Domains for PRELID3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRELID3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N28

UniProtKB/Swiss-Prot:

PLD3A_HUMAN :
  • Contains 1 PRELI/MSF1 domain.
  • Belongs to the slowmo family.
Domain:
  • Contains 1 PRELI/MSF1 domain.
Family:
  • Belongs to the slowmo family.
genes like me logo Genes that share domains with PRELID3A: view

Function for PRELID3A Gene

Molecular function for PRELID3A Gene

UniProtKB/Swiss-Prot Function:
In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.

Gene Ontology (GO) - Molecular Function for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 26071602
GO:0046872 metal ion binding IEA --
GO:1990050 phosphatidic acid transporter activity IDA 26071602
genes like me logo Genes that share ontologies with PRELID3A: view

Phenotypes for PRELID3A Gene

GenomeRNAi human phenotypes for PRELID3A:
genes like me logo Genes that share phenotypes with PRELID3A: view

Animal Model Products

miRNA for PRELID3A Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRELID3A Gene

Localization for PRELID3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRELID3A Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRELID3A gene
Compartment Confidence
mitochondrion 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IBA --
genes like me logo Genes that share ontologies with PRELID3A: view

Pathways & Interactions for PRELID3A Gene

genes like me logo Genes that share pathways with PRELID3A: view

Interacting Proteins for PRELID3A Gene

Gene Ontology (GO) - Biological Process for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006810 transport IEA --
GO:0006869 lipid transport IEA --
GO:0015914 phospholipid transport IDA 26071602
genes like me logo Genes that share ontologies with PRELID3A: view

No data available for SIGNOR curated interactions for PRELID3A Gene

Transcripts for PRELID3A Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRELID3A Gene

No ASD Table

Relevant External Links for PRELID3A Gene

GeneLoc Exon Structure for
PRELID3A
ECgene alternative splicing isoforms for
PRELID3A

Expression for PRELID3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of PRELID3A Gene:

PRELID3A
genes like me logo Genes that share expression patterns with PRELID3A: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PRELID3A Gene

Orthologs for PRELID3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRELID3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLMO1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slmo1 34
  • 85.85 (n)
cow
(Bos Taurus)
Mammalia SLMO1 34 35
  • 85.27 (n)
mouse
(Mus musculus)
Mammalia Slmo1 34 16 35
  • 85.27 (n)
dog
(Canis familiaris)
Mammalia SLMO1 34 35
  • 84.68 (n)
oppossum
(Monodelphis domestica)
Mammalia SLMO1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLMO1 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLMO1 34 35
  • 77.03 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slmo1 34
  • 72.87 (n)
zebrafish
(Danio rerio)
Actinopterygii slmo1 35
  • 75 (a)
OneToOne
LOC563270 34
  • 71.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta slmo 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F15D3.6 35
  • 31 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18348g 34
  • 48.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UPS2 34 35
  • 45.33 (n)
UPS3 35
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04307 34
  • 46.06 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC36.10 34
  • 42.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.655 35
  • 30 (a)
OneToMany
Species where no ortholog for PRELID3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRELID3A Gene

ENSEMBL:
Gene Tree for PRELID3A (if available)
TreeFam:
Gene Tree for PRELID3A (if available)

Paralogs for PRELID3A Gene

Paralogs for PRELID3A Gene

Pseudogenes.org Pseudogenes for PRELID3A Gene

genes like me logo Genes that share paralogs with PRELID3A: view

Variants for PRELID3A Gene

Sequence variations from dbSNP and Humsavar for PRELID3A Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10164125 -- 12,410,279(+) TCCTT(C/G)CAGGA intron-variant
rs1046797 -- 12,431,922(-) TCAAA(A/C)CTTGG upstream-variant-2KB, utr-variant-3-prime
rs1078387 -- 12,405,962(-) ATGTG(C/T)GGACA upstream-variant-2KB
rs11080576 -- 12,413,209(+) cctag(A/C)ggggg intron-variant
rs11080577 -- 12,416,723(+) TCACT(A/G)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRELID3A Gene

Variant ID Type Subtype PubMed ID
nsv9610 CNV gain 18304495
nsv576496 CNV gain 21841781
nsv519557 CNV loss 19592680
nsv130656 CNV deletion 16902084
nsv1063125 CNV loss 25217958
nsv1060808 CNV gain 25217958
esv3341464 CNV duplication 20981092
esv2758714 CNV loss 17122850

Variation tolerance for PRELID3A Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRELID3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRELID3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRELID3A Gene

Disorders for PRELID3A Gene

Relevant External Links for PRELID3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRELID3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRELID3A

No disorders were found for PRELID3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRELID3A Gene

Publications for PRELID3A Gene

  1. Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. (PMID: 26071602) Miliara X. … Matthews S. (EMBO Rep. 2015) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3 64

Products for PRELID3A Gene

Sources for PRELID3A Gene

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