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Aliases for PRELID3A Gene

Aliases for PRELID3A Gene

  • PRELI Domain Containing 3A 2 3 5
  • Erythroid Differentiation And Denucleation Factor 1 2 3
  • Protein Slowmo Homolog 1 3 4
  • C18orf43 3 4
  • SLMO1 3 4
  • Chromosome 18 Open Reading Frame 43 2
  • Slowmo Homolog 1 (Drosophila) 2
  • Slowmo Homolog 1 3
  • HFL-EDDG1 3

External Ids for PRELID3A Gene

Previous HGNC Symbols for PRELID3A Gene

  • C18orf43
  • SLMO1

Summaries for PRELID3A Gene

GeneCards Summary for PRELID3A Gene

PRELID3A (PRELI Domain Containing 3A) is a Protein Coding gene. An important paralog of this gene is PRELID2.

UniProtKB/Swiss-Prot for PRELID3A Gene

  • In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRELID3A Gene

Genomics for PRELID3A Gene

Regulatory Elements for PRELID3A Gene

Enhancers for PRELID3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRELID3A on UCSC Golden Path with GeneCards custom track

Promoters for PRELID3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRELID3A on UCSC Golden Path with GeneCards custom track

Genomic Location for PRELID3A Gene

Chromosome:
18
Start:
12,407,896 bp from pter
End:
12,432,238 bp from pter
Size:
24,343 bases
Orientation:
Plus strand

Genomic View for PRELID3A Gene

Genes around PRELID3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRELID3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRELID3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRELID3A Gene

Proteins for PRELID3A Gene

  • Protein details for PRELID3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N28-PLD3A_HUMAN
    Recommended name:
    PRELI domain containing protein 3A
    Protein Accession:
    Q96N28
    Secondary Accessions:
    • B0YJ10
    • B4E0C9
    • D3DUJ1
    • Q6AHX2

    Protein attributes for PRELID3A Gene

    Size:
    172 amino acids
    Molecular mass:
    19247 Da
    Quaternary structure:
    • Interacts with TRIAP1.

    Three dimensional structures from OCA and Proteopedia for PRELID3A Gene

    Alternative splice isoforms for PRELID3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRELID3A Gene

Proteomics data for PRELID3A Gene at MOPED

Post-translational modifications for PRELID3A Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRELID3A Gene

Domains & Families for PRELID3A Gene

Protein Domains for PRELID3A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRELID3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96N28

UniProtKB/Swiss-Prot:

PLD3A_HUMAN :
  • Contains 1 PRELI/MSF1 domain.
  • Belongs to the slowmo family.
Domain:
  • Contains 1 PRELI/MSF1 domain.
Family:
  • Belongs to the slowmo family.
genes like me logo Genes that share domains with PRELID3A: view

No data available for Gene Families for PRELID3A Gene

Function for PRELID3A Gene

Molecular function for PRELID3A Gene

UniProtKB/Swiss-Prot Function:
In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.

Gene Ontology (GO) - Molecular Function for PRELID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26071602
genes like me logo Genes that share ontologies with PRELID3A: view

Phenotypes for PRELID3A Gene

GenomeRNAi human phenotypes for PRELID3A:
genes like me logo Genes that share phenotypes with PRELID3A: view

Animal Model Products

miRNA for PRELID3A Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRELID3A Gene

Localization for PRELID3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRELID3A Gene

Mitochondrion.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PRELID3A Gene

Pathways & Interactions for PRELID3A Gene

SuperPathways for PRELID3A Gene

No Data Available

Interacting Proteins for PRELID3A Gene

Gene Ontology (GO) - Biological Process for PRELID3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PRELID3A Gene

Drugs & Compounds for PRELID3A Gene

No Compound Related Data Available

Transcripts for PRELID3A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PRELID3A Gene

No ASD Table

Relevant External Links for PRELID3A Gene

GeneLoc Exon Structure for
PRELID3A
ECgene alternative splicing isoforms for
PRELID3A

Expression for PRELID3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with PRELID3A: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRELID3A Gene

Orthologs for PRELID3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRELID3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLMO1 35
  • 85.27 (n)
  • 89.53 (a)
SLMO1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLMO1 35
  • 84.68 (n)
  • 90.06 (a)
SLMO1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slmo1 35
  • 85.85 (n)
  • 90.12 (a)
mouse
(Mus musculus)
Mammalia Slmo1 16
Slmo1 36
  • 90 (a)
OneToOne
Slmo1 35
  • 85.27 (n)
  • 90.12 (a)
oppossum
(Monodelphis domestica)
Mammalia SLMO1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLMO1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLMO1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLMO1 35
  • 77.03 (n)
  • 87.8 (a)
SLMO1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slmo1 35
  • 72.87 (n)
  • 83.14 (a)
zebrafish
(Danio rerio)
Actinopterygii slmo1 36
  • 75 (a)
OneToOne
LOC563270 35
  • 71.83 (n)
  • 78.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta slmo 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F15D3.6 36
  • 31 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18348g 35
  • 48.17 (n)
  • 36.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UPS2 35
  • 45.33 (n)
  • 35.37 (a)
UPS2 36
  • 26 (a)
ManyToMany
UPS3 36
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04307 35
  • 46.06 (n)
  • 32.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC36.10 35
  • 42.13 (n)
  • 33.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.655 36
  • 30 (a)
OneToMany
Species with no ortholog for PRELID3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRELID3A Gene

ENSEMBL:
Gene Tree for PRELID3A (if available)
TreeFam:
Gene Tree for PRELID3A (if available)

Paralogs for PRELID3A Gene

Paralogs for PRELID3A Gene

Pseudogenes.org Pseudogenes for PRELID3A Gene

genes like me logo Genes that share paralogs with PRELID3A: view

Variants for PRELID3A Gene

Sequence variations from dbSNP and Humsavar for PRELID3A Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs4797685 -- 12,427,545(+) CAAAA(A/G)TTAGC intron-variant
rs1785318 -- 12,409,956(+) CTTCT(A/G)TCCTC intron-variant
rs1785322 -- 12,416,268(+) GAAAG(C/T)GTGTC intron-variant
rs1785323 -- 12,416,794(+) acgcc(C/T)gccac intron-variant
rs1785326 -- 12,419,777(+) gaaaa(A/C)aatta intron-variant, upstream-variant-2KB

Variation tolerance for PRELID3A Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRELID3A Gene

HapMap Linkage Disequilibrium report
PRELID3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PRELID3A Gene

Disorders for PRELID3A Gene

Relevant External Links for PRELID3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRELID3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRELID3A

No disorders were found for PRELID3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRELID3A Gene

Publications for PRELID3A Gene

  1. Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. (PMID: 26071602) Miliara X. … Matthews S. (EMBO Rep. 2015) 3 4 67
  2. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for PRELID3A Gene

Sources for PRELID3A Gene

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