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PRELID2 Gene

protein-coding   GIFtS: 43
GCID: GC05M144851

PRELI Domain Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PRELI Domain Containing 21 2
PRELI Domain-Containing Protein 22

External Ids:    HGNC: 283061   Entrez Gene: 1537682   Ensembl: ENSG000001863147   UniProtKB: Q8N9453   

Export aliases for PRELID2 gene to outside databases

Previous GC identifers: GC05M145119 GC05M140285


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRELID2 Gene:
PRELID2 (PRELI domain containing 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRELID2 gene promoter:
         Sox5   PPAR-gamma1   MyoD   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRELID2 promoter sequence
   Search Chromatin IP Primers for PRELID2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRELID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

PRELID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRELID2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M144851:  view genomic region     (about GC identifiers)

Start:
144,851,362 bp from pter      End:
145,214,932 bp from pter
Size:
363,571 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRLD2_HUMAN, Q8N945 (See protein sequence)
Recommended Name: PRELI domain-containing protein 2  
Size: 189 amino acids; 21905 Da
Sequence caution: Sequence=BQ425760; Type=Frameshift; Positions=143, 169;
Secondary accessions: G5EA01 Q96EQ3
Alternative splicing: 3 isoforms:  Q8N945-1   Q8N945-2   Q8N945-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRELID2: NX_Q8N945

Explore proteomics data for PRELID2 at MOPED


See PRELID2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_612501.3  NP_892005.1  NP_995318.1  

ENSEMBL proteins: 
 ENSP00000335675   ENSP00000377965   ENSP00000424730   ENSP00000422789   ENSP00000350694  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR006797 PRELI/MSF1

Graphical View of Domain Structure for InterPro Entry Q8N945

ProtoNet protein and cluster: Q8N945

UniProtKB/Swiss-Prot: PRLD2_HUMAN, Q8N945
Similarity: Contains 1 PRELI/MSF1 domain


Find genes that share domains with PRELID2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:1990050phosphatidic acid transporter activity IBA--
     
Find genes that share ontologies with PRELID2           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for PRELID2

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
mitochondrion2
nucleus2
endoplasmic reticulum1
extracellular1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005758mitochondrial intermembrane space IBA--

Find genes that share ontologies with PRELID2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRELID2
Interactions:

    Search GeneGlobe Interaction Network for PRELID2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for PRELID2 (ENSP000003356754) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DOHHENSP000002509374STRING: ENSP00000250937
PRELID1ENSP000003021144STRING: ENSP00000302114
FARS2ENSP000002746804STRING: ENSP00000274680
FDXACB1ENSP000002602574STRING: ENSP00000260257
--ENSP000003049974STRING: ENSP00000304997
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015914phospholipid transport IBA--

Find genes that share ontologies with PRELID2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for PRELID2 (PRLD2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for PRELID2 gene (3 alternative transcripts): 
NM_138492.5  NM_182960.3  NM_205846.2  

Unigene Cluster for PRELID2:

PRELI domain containing 2
Hs.314261  [show with all ESTs]
Unigene Representative Sequence: NM_138492
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000510259 ENST00000510594 ENST00000515161 ENST00000334744(uc003lnp.1)
ENST00000394450 ENST00000505416 ENST00000511435(uc003lnr.1) ENST00000515475
ENST00000505097 ENST00000358004(uc003lno.1 uc003lnq.1)
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hsa-miR-607 hsa-miR-4311 hsa-miR-3653 hsa-miR-944 hsa-miR-548s hsa-miR-606 hsa-miR-378b hsa-miR-3658
SwitchGear 3'UTR luciferase reporter plasmidPRELID2 3' UTR sequence
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Additional mRNA sequence: 

AK095695.1 AK125215.1 BC012033.1 

7 DOTS entries:

DT.100022061  DT.100747811  DT.95378594  DT.99992379  DT.100022060  DT.92070230  DT.95256451 

Selected AceView cDNA sequences (see all 63):

Z41436 AW770245 BU186346 T17370 CB156125 H73347 BC012033 AK125215 
BQ082012 BU167299 BM975928 AI570939 NM_205846 AI440137 NM_182960 CA335264 
BQ646437 AA448161 BQ439188 AA600988 AW961680 CA433494 NM_138492 AI275055 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PRELID2    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1:                                                  -     -                 -                           
SP2:                                -                 -                       -                           
SP3:                                -                 -     -                 -           -               
SP4:                                -                 -     -                                             
SP5:                                -                                                                     


ECgene alternative splicing isoforms for PRELID2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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PRELID2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCTACTTTTT
PRELID2 Expression
About this image

PRELID2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PRELID2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.314261
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for PRELID2 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Prelid21 , 5 PRELI domain containing 21, 5 88.14(n)1
88.7(a)1
  18 (22.02 cM)5
776191  NM_029942.11  NP_084218.11 
 418756965 
lizard
(Anolis carolinensis)
Reptilia PRELID26
PRELI domain containing 2
68(a)
1 ↔ 1
GL343234.1(903355-961385)
African clawed frog
(Xenopus laevis)
Amphibia Xl.81142 Xenopus laevis transcribed sequence with weak similarity more 76(n)    48019575 


ENSEMBL Gene Tree for PRELID2 (if available)
TreeFam Gene Tree for PRELID2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for PRELID2 gene
1 SIMAP similar gene for PRELID2 using alignment to 2 protein entries:     PRLD2_HUMAN (see all proteins):
SLMO1

Find genes that share paralogs with PRELID2           About GenesLikeMe


1 Pseudogenes.org Pseudogene for PRELID2
PGOHUM00000239514


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for PRELID2 (see all 1634)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1892681741,2
C--140284830(+) GAAGGC/GTTAAA 3 -- int10--------
rs1815218581,2
--140284836(+) TTAAAC/TTTACT 3 -- int10--------
rs1473038911,2
--140284842(+) TTACTC/GTAATG 3 -- int10--------
rs1431134261,2
--140284937(+) AAAAGC/TCTACC 3 -- int10--------
rs1850359251,2
--140284997(+) CTACCA/GTTATT 3 -- int10--------
rs1906910141,2
--140285112(+) CACAGC/TGGCAG 3 -- int10--------
rs1446570341,2
--140285122(+) GGCTTG/TTATGA 3 -- int10--------
rs1485070551,2
--140285185(+) GACATG/TTTAAA 3 -- int10--------
rs1819815431,2
--140285197(+) AAAAAA/TTTCCC 3 -- int10--------
rs1860920431,2
--140285220(+) GTAACA/GGCCTG 3 -- int10--------

HapMap Linkage Disequilibrium report for PRELID2 (144851362 - 145101362 bp, first 250kb of PRELID2)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for PRELID2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv462474CNV Loss19166990
esv23730CNV Gain19812545

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with PRELID2           About GenesLikeMe

Genetic Association Database (GAD): PRELID2
Human Genome Epidemiology (HuGE) Navigator: PRELID2 (2 documents)

Export disorders for PRELID2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for PRELID2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with PRELID2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 153768 HGNC: 28306 AceView: MGC21644 Ensembl:ENSG00000186314 euGenes: HUgn153768
ECgene: PRELID2 H-InvDB: PRELID2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for PRELID2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for PRELID2 gene:
Search GeneIP for patents involving PRELID2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PRELID2  
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 OriGene Custom Antibody Services for PRELID2   OriGene Custom Protein Services for PRELID2  

 
 
 Block miRNA regulation of human, mouse, rat PRELID2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRELID2
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRELID2 Predesigned siRNA for gene silencing in human, mouse, rat PRELID2
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 Custom PCR Arrays for PRELID2 Search Chromatin IP Primers for PRELID2
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 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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 Search Tocris compounds for PRELID2 (PRLD2)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for PRELID2
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 Gene Synthesis
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 SwitchGear 3'UTR luciferase reporter plasmids for PRELID2
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 genOway: Develop your customized and physiologically relevant rodent model for PRELID2
 antibodies-online antibodies for PRELID2 (4 products)
 antibodies-online kits for PRELID2 (4 products)
 antibodies-online peptides for PRELID2
 antibodies-online proteins for PRELID2 (4 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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