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Aliases for PRELID2 Gene

Aliases for PRELID2 Gene

  • PRELI Domain Containing 2 2 3 5
  • PRELI Domain-Containing Protein 2 3
  • CTC-806A22.1 3

External Ids for PRELID2 Gene

Previous GeneCards Identifiers for PRELID2 Gene

  • GC05M145119
  • GC05M144851
  • GC05M140285
  • GC05M145471

Summaries for PRELID2 Gene

GeneCards Summary for PRELID2 Gene

PRELID2 (PRELI Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidic acid transporter activity. An important paralog of this gene is PRELID3A.

Additional gene information for PRELID2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRELID2 Gene

Genomics for PRELID2 Gene

GeneHancer (GH) Regulatory Elements for PRELID2 Gene

Promoters and enhancers for PRELID2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I145833 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 77 3.8 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B PRELID2 GRXCR2 LARS TCERG1 GC05M145704
GH05I145851 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -19.0 -19013 5.2 HDGF PKNOX1 FOXA2 ARNT POLR2B ZNF766 E2F8 ZNF143 FOS ZNF592 GRXCR2 SH3RF2 PRELID2 GC05P145887
GH05I145838 Enhancer 0.5 ENCODE dbSUPER 0.8 -3.1 -3100 0.2 HLF GRXCR2 PRELID2 GC05P145887
GH05I145847 Enhancer 0.6 ENCODE 0.4 -12.9 -12919 1.8 AFF1 PHF21A DPF2 FOSL1 NFIC JUND HMBOX1 KDM1A FOS SPI1 GRXCR2 SH3RF2 ASS1P10 PRELID2 GC05P145887
GH05I145774 Enhancer 0.9 Ensembl ENCODE 0.2 +59.5 59496 2.2 FOXA2 SAP130 JUN MAX CEBPG ZIC2 RFX5 FOSL1 POLR2A FOSL2 ASS1P10 GC05M145704 PRELID2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PRELID2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PRELID2 gene promoter:

Genomic Locations for PRELID2 Gene

Genomic Locations for PRELID2 Gene
chr5:145,337,932-145,835,383
(GRCh38/hg38)
Size:
497,452 bases
Orientation:
Minus strand
chr5:144,851,362-145,214,932
(GRCh37/hg19)

Genomic View for PRELID2 Gene

Genes around PRELID2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRELID2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRELID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRELID2 Gene

Proteins for PRELID2 Gene

  • Protein details for PRELID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N945-PRLD2_HUMAN
    Recommended name:
    PRELI domain-containing protein 2
    Protein Accession:
    Q8N945
    Secondary Accessions:
    • G5EA01
    • Q96EQ3

    Protein attributes for PRELID2 Gene

    Size:
    189 amino acids
    Molecular mass:
    21905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BQ425760; Type=Frameshift; Positions=143, 169; Evidence={ECO:0000305};

    Alternative splice isoforms for PRELID2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRELID2 Gene

Post-translational modifications for PRELID2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PRELID2 Gene

Domains & Families for PRELID2 Gene

Gene Families for PRELID2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRELID2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRELID2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRELID2: view

No data available for UniProtKB/Swiss-Prot for PRELID2 Gene

Function for PRELID2 Gene

Phenotypes From GWAS Catalog for PRELID2 Gene

Gene Ontology (GO) - Molecular Function for PRELID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990050 phosphatidic acid transporter activity IBA --
genes like me logo Genes that share ontologies with PRELID2: view

Phenotypes for PRELID2 Gene

MGI mutant phenotypes for PRELID2:
inferred from 1 alleles
GenomeRNAi human phenotypes for PRELID2:
genes like me logo Genes that share phenotypes with PRELID2: view

Animal Models for PRELID2 Gene

MGI Knock Outs for PRELID2:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRELID2 Gene

Localization for PRELID2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRELID2 gene
Compartment Confidence
mitochondrion 4
nucleus 3
cytosol 2
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PRELID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005758 mitochondrial intermembrane space IBA,IEA --
genes like me logo Genes that share ontologies with PRELID2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRELID2 Gene

Pathways & Interactions for PRELID2 Gene

SuperPathways for PRELID2 Gene

No Data Available

Interacting Proteins for PRELID2 Gene

Gene Ontology (GO) - Biological Process for PRELID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015914 phospholipid transport IEA --
genes like me logo Genes that share ontologies with PRELID2: view

No data available for Pathways by source and SIGNOR curated interactions for PRELID2 Gene

Drugs & Compounds for PRELID2 Gene

No Compound Related Data Available

Transcripts for PRELID2 Gene

Unigene Clusters for PRELID2 Gene

PRELI domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRELID2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: -

Relevant External Links for PRELID2 Gene

GeneLoc Exon Structure for
PRELID2
ECgene alternative splicing isoforms for
PRELID2

Expression for PRELID2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRELID2 Gene

mRNA differential expression in normal tissues according to GTEx for PRELID2 Gene

This gene is overexpressed in Colon - Transverse (x6.4).

Protein differential expression in normal tissues from HIPED for PRELID2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRELID2 Gene



Protein tissue co-expression partners for PRELID2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRELID2 Gene:

PRELID2

SOURCE GeneReport for Unigene cluster for PRELID2 Gene:

Hs.314261

Evidence on tissue expression from TISSUES for PRELID2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PRELID2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRELID2 Gene

Orthologs for PRELID2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRELID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRELID2 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia PRELID2 33 34
  • 92.66 (n)
cow
(Bos Taurus)
Mammalia LOC524741 33
  • 90.09 (n)
PRELID2 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prelid2 33
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Prelid2 33 16 34
  • 88.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRELID2 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRELID2 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRELID2 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prelid2 33
  • 64.77 (n)
Str.15586 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8114 33
Species where no ortholog for PRELID2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRELID2 Gene

ENSEMBL:
Gene Tree for PRELID2 (if available)
TreeFam:
Gene Tree for PRELID2 (if available)

Paralogs for PRELID2 Gene

Paralogs for PRELID2 Gene

(1) SIMAP similar genes for PRELID2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PRELID2 Gene

genes like me logo Genes that share paralogs with PRELID2: view

Variants for PRELID2 Gene

Sequence variations from dbSNP and Humsavar for PRELID2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000007813 -- 145,668,618(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000009510 -- 145,833,832(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000016150 -- 145,646,437(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000049676 -- 145,608,498(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000058794 -- 145,769,274(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PRELID2 Gene

Variant ID Type Subtype PubMed ID
dgv1655e212 CNV loss 25503493
esv23730 CNV gain 19812545
esv3570480 CNV loss 25503493
nsv1021851 CNV loss 25217958
nsv462474 CNV loss 19166990
nsv599934 CNV loss 21841781

Variation tolerance for PRELID2 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.29; 53.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PRELID2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRELID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRELID2 Gene

Disorders for PRELID2 Gene

Additional Disease Information for PRELID2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PRELID2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRELID2 Gene

Publications for PRELID2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58

Products for PRELID2 Gene

Sources for PRELID2 Gene

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