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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PREB Gene

protein-coding   GIFtS: 59
GCID: GC02M027353

Prolactin Regulatory Element Binding

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prolactin Regulatory Element Binding1 2
Mammalian Guanine Nucleotide Exchange Factor MSec122 3
SEC122 3
Prolactin Regulatory Binding-Element Protein2
Prolactin Regulatory Element-Binding Protein2

External Ids:    HGNC: 93561   Entrez Gene: 101132   Ensembl: ENSG000001380737   OMIM: 6063955   UniProtKB: Q9HCU53   

Export aliases for PREB gene to outside databases

Previous GC identifers: GC02M027274 GC02M027446 GC02M027311 GC02M027328 GC02M027265 GC02M027207 GC02M027095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PREB Gene:
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter.
This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental
abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing
1 (ABHD1) gene on the opposite strand. (provided by RefSeq, Jul 2008)

GeneCards Summary for PREB Gene: 
PREB (prolactin regulatory element binding) is a protein-coding gene. Diseases associated with PREB include testicular leukemia, and endotheliitis, and among its related super-pathways are COPII (Coat Protein 2) Mediated Vesicle Transport and WNT ligand biogenesis and trafficking. GO annotations related to this gene include DNA binding.

UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5
Function: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds
to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide
exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER

Gene Wiki entry for PREB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PREB gene promoter:
         AP-1   ATF-2   NF-kappaB   HEN1   HOXA5   STAT3   c-Jun   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPREB promoter sequence
   Search SABiosciences Chromatin IP Primers for PREB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PREB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

PREB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PREB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027353:  view genomic region     (about GC identifiers)

Start:
27,353,624 bp from pter      End:
27,357,543 bp from pter
Size:
3,920 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5 (See protein sequence)
Recommended Name: Prolactin regulatory element-binding protein  
Size: 417 amino acids; 45468 Da
Subunit: Binds SARA2
Subcellular location: Nucleus (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By
similarity)
Secondary accessions: Q53SZ8 Q9UH94

Explore the universe of human proteins at neXtProt for PREB: NX_Q9HCU5

Explore proteomics data for PREB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCU5

  • PREB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PREB Protein Expression
    REFSEQ proteins: NP_037520.1  
    ENSEMBL proteins: 
     ENSP00000260643   ENSP00000416103   ENSP00000384032   ENSP00000397036   ENSP00000407036  
     ENSP00000391894  
    Reactome Protein details: Q9HCU5
    Human Recombinant Protein Products for PREB: 
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    Novus Biologicals PREB Proteins
    Novus Biologicals PREB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PREB 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    PREB for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for PREB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCU5

    ProtoNet protein and cluster: Q9HCU5

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5
    Similarity: Contains 3 WD repeats


    PREB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PREB_HUMAN, Q9HCU5
    Function: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds
    to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide
    exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
         
    PREB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PREB 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PREB 
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    miRNA
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    hsa-miR-34c-5p hsa-miR-449b hsa-miR-198 hsa-miR-130a* hsa-miR-545 hsa-miR-23c hsa-miR-449a hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidPREB 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PREB About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1COPII (Coat Protein 2) Mediated Vesicle Transport
    COPII (Coat Protein 2) Mediated Vesicle Transport0.36
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    ER to Golgi Transport0.36
    2Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    3Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    4Clathrin-dependent protein traffic
    Transport Clathrin-coated vesicle cycle0.66
    5N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for PREB
        Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    5/13        Reactome Pathways for PREB (see all 13)
        Membrane Trafficking
    Signaling by Wnt
    Asparagine N-linked glycosylation
    COPII (Coat Protein 2) Mediated Vesicle Transport
    ER to Golgi Transport


    1         Kegg Pathway  (Kegg details for PREB):
        Protein processing in endoplasmic reticulum


    PREB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PREB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for PREB (Q9HCU53 ENSP000002606434) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156453, ENSP000001663454I2D: score=1 STRING: ENSP00000166345
    SMAD1Q157973, ENSP000003057694I2D: score=3 STRING: ENSP00000305769
    TGFBR1P368973, ENSP000003641334I2D: score=4 STRING: ENSP00000364133
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0015031protein transport IEA--

    PREB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PREB

    3 HMDB Compounds for PREB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about PREB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PREB gene: 
    NM_013388.4  

    Unigene Cluster for PREB:

    Prolactin regulatory element binding
    Hs.279784  [show with all ESTs]
    Unigene Representative Sequence: BC036185
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468045 ENST00000260643(uc002rix.1 uc002riy.1) ENST00000444452
    ENST00000406567 ENST00000456259 ENST00000430533 ENST00000441451 ENST00000474802
    ENST00000416802
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PREB (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-198 hsa-miR-130a* hsa-miR-545 hsa-miR-23c hsa-miR-449a hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidPREB 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF203687.1 AF226684.1 AK001976.1 AK023064.1 AK023405.1 AK292178.1 BC002765.2 BC008658.1 
    BC012890.1 BC016472.1 BC016906.1 BC036185.1 BC041032.1 

    17 DOTS entries:

    DT.95309112  DT.443424  DT.101985109  DT.97849854  DT.100877093  DT.91773209  DT.121009821  DT.95368732 
    DT.121009859  DT.95368742  DT.97849847  DT.100030138  DT.100877118  DT.121009844  DT.121009850  DT.121009858 
    DT.95155684 

    24/404 AceView cDNA sequences (see all 404):

    BM742664 BU741412 AU280660 AK023064 BC002765 BQ056953 BC016472 CB151415 
    BU169223 BP363839 AW402477 AI089337 AI689551 AL583240 BQ645562 BG913621 
    CR620242 CR622322 AA687138 AI085046 CD106190 BQ920980 BQ425317 AU130192 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PREB (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
    SP1:                                      -                             -                                                     -     -     -                     
    SP2:                                                                    -                                                     -                                 
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                          -                                 
    SP5:                                                                    -                                                                                       

    ExUns: 11b ^ 12a · 12b · 12c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PREB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PREB expression in normal human tissues (normalized intensities)      PREB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCCCTGG
    PREB Expression
    About this image


    PREB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   

    See PREB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PREB

    SOURCE GeneReport for Unigene cluster: Hs.279784

    UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PREB gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Preb1 , 5 prolactin regulatory element binding1, 5 87.05(n)1
    88.73(a)1
      5 (16.90 cM)5
    509071  NM_016703.21  NP_057912.21 
     309508535 
    chicken
    (Gallus gallus)
    Aves LOC1008589861 prolactin regulatory element-binding protein-like 70.4(n)
    71.98(a)
      100858986  XM_003643516.1  XP_003643564.1 
    lizard
    (Anolis carolinensis)
    Reptilia PREB6
    Uncharacterized protein
    53(a)
    1 ↔ 1
    AAWZ02041606(3881-5460)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX846331.12   -- 71.98(n)    BX846331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3852 sbcb385 75.57(n)   368318  CF348612.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91751 , 3 DNA binding3
    CG91751
    32(a)3
    48.21(n)1
    35.41(a)1
      26B93
    338621  NM_164681.21  NP_723155.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-121 Protein SEC-12 40.71(n)
    28.53(a)
      172641  NM_059904.3  NP_492305.2 


    ENSEMBL Gene Tree for PREB (if available)
    TreeFam Gene Tree for PREB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 SNPs in PREB are shown (see all 174)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127065551,2
    C,F--27277243(+) AGCTGC/TGGACC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs739214571,2
    C--27277254(+) CGAATG/AGAGTG 1 -- ut312Minor allele frequency- A:0.04WA 120
    rs612767761,2
    C,F--27277361(+) GCACTC/TTGGAG 2 Q syn13Minor allele frequency- T:0.01WA NA 3514
    rs1403182871,2
    C--27277409(+) AGGAGC/GAGGAG 2 L syn11Minor allele frequency- G:0.00NA 3706
    rs1395509731,2
    C,F--27277412(+) AGCAGG/AAGCCA 2 /L syn11Minor allele frequency- A:0.00NA 3698
    rs745512041,2
    C,F--27277427(+) GGAACA/GCTCCC 2 S syn12Minor allele frequency- G:0.02WA NA 3702
    rs116956411,2
    C,F,H--27277474(+) GGCTTC/TCCAGC 1 -- int12Minor allele frequency- T:0.13NA EU 569
    rs1153456521,2
    F--27277525(+) GCCCAG/ACCTCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs2002881651,2
    C--27277560(+) ACGTGA/GGGTGG 1 -- int10--------
    rs1998265711,2
    C--27277595(+) CTCACA/GCCGTG 2 R W mis10--------

    HapMap Linkage Disequilibrium report for PREB (27353624 - 27357543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PREB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833603CNV Loss17160897
    nsv817673CNV Gain17921354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606395    OMIM disorders: --

    3 diseases for PREB:    About MalaCards
    testicular leukemia    endotheliitis    leukemia

    2 diseases from the University of Copenhagen DISEASES database for PREB:
    Leukemia     Testicular leukemia

    PREB for disorders           About GeneDecksing

    Genetic Association Database (GAD): PREB
    Human Genome Epidemiology (HuGE) Navigator: PREB (3 documents)

    Export disorders for PREB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PREB gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with PREB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. (PubMed id 12735795)1, 2, 3, 9 Edgar A.J. (2003)
    2. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. (PubMed id 10194769)1, 3, 9 Fliss M.S....Bancroft C. (1999)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome. (PubMed id 10920239)1, 2 Taylor Clelland C.L.... Bancroft C. (2000)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10113 HGNC: 9356 AceView: PREB Ensembl:ENSG00000138073 euGenes: HUgn10113
    ECgene: PREB Kegg: 10113 H-InvDB: PREB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PREB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PREB gene:
    Search GeneIP for patents involving PREB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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