Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PREB Gene

Aliases for PREB Gene

  • Prolactin Regulatory Element Binding 2 3
  • Mammalian Guanine Nucleotide Exchange Factor MSec12 3 4
  • SEC12 3 4
  • Prolactin Regulatory Binding-Element Protein 3
  • Prolactin Regulatory Element-Binding Protein 3

External Ids for PREB Gene

Summaries for PREB Gene

Entrez Gene Summary for PREB Gene

  • This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

GeneCards Summary for PREB Gene

PREB (Prolactin Regulatory Element Binding) is a Protein Coding gene. Diseases associated with PREB include testicular leukemia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

UniProtKB/Swiss-Prot for PREB Gene

  • Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

Gene Wiki entry for PREB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PREB Gene

Genomics for PREB Gene

Genomic Location for PREB Gene

Start:
27,130,756 bp from pter
End:
27,134,675 bp from pter
Size:
3,920 bases
Orientation:
Minus strand

Genomic View for PREB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PREB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PREB Gene

Regulatory Elements for PREB Gene

Proteins for PREB Gene

  • Protein details for PREB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCU5-PREB_HUMAN
    Recommended name:
    Prolactin regulatory element-binding protein
    Protein Accession:
    Q9HCU5
    Secondary Accessions:
    • Q53SZ8
    • Q9UH94

    Protein attributes for PREB Gene

    Size:
    417 amino acids
    Molecular mass:
    45468 Da
    Quaternary structure:
    • Binds SARA2

neXtProt entry for PREB Gene

Proteomics data for PREB Gene at MOPED

Post-translational modifications for PREB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys38, Lys188, Lys209, Lys224, and Lys272

Other Protein References for PREB Gene

No data available for DME Specific Peptides for PREB Gene

Domains for PREB Gene

Gene Families for PREB Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for PREB Gene

Suggested Antigen Peptide Sequences for PREB Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCU5

UniProtKB/Swiss-Prot:

PREB_HUMAN
Similarity:
  • Contains 7 WD repeats.:
    • Q9HCU5
genes like me logo Genes that share domains with PREB: view

Function for PREB Gene

Molecular function for PREB Gene

UniProtKB/Swiss-Prot Function: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

Gene Ontology (GO) - Molecular Function for PREB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PREB: view

miRNA for PREB Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PREB Gene

Localization for PREB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PREB Gene

Nucleus. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PREB Gene COMPARTMENTS Subcellular localization image for PREB gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
mitochondrion 2
cytoskeleton 1
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PREB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PREB: view

Pathways for PREB Gene

genes like me logo Genes that share pathways with PREB: view

Gene Ontology (GO) - Biological Process for PREB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with PREB: view

Compounds for PREB Gene

(3) HMDB Compounds for PREB Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with PREB: view

Transcripts for PREB Gene

Unigene Clusters for PREB Gene

Prolactin regulatory element binding:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PREB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10: -
SP11: -
SP12: - - - - - -
SP13: - -

ExUns: 11b ^ 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for PREB Gene

GeneLoc Exon Structure for
PREB
ECgene alternative splicing isoforms for
PREB

Expression for PREB Gene

mRNA expression in normal human tissues for PREB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PREB Gene

SOURCE GeneReport for Unigene cluster for PREB Gene Hs.279784

mRNA Expression by UniProt/SwissProt for PREB Gene

Q9HCU5-PREB_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with PREB: view

No data available for mRNA differential expression in normal tissues for PREB Gene

Orthologs for PREB Gene

This gene was present in the common ancestor of animals.

Orthologs for PREB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PREB 35
  • 99.76 (n)
  • 99.52 (a)
PREB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PREB 35
  • 90.89 (n)
  • 92.81 (a)
PREB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PREB 35
  • 91.53 (n)
  • 93.05 (a)
PREB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Preb 35
  • 87.05 (n)
  • 88.73 (a)
Preb 16
Preb 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PREB 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PREB 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Preb 35
  • 87.61 (n)
  • 89.45 (a)
chicken
(Gallus gallus)
Aves PREB 35
  • 70.4 (n)
  • 71.98 (a)
PREB 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PREB 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia preb 35
  • 64.99 (n)
  • 61.63 (a)
Str.2368 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9088 35
zebrafish
(Danio rerio)
Actinopterygii preb 35
  • 60.11 (n)
  • 58.27 (a)
preb 36
  • 56 (a)
OneToOne
sbcb385 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009942 35
  • 48.18 (n)
  • 36.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9175 35
  • 48.05 (n)
  • 35.16 (a)
CG9175 36
  • 32 (a)
OneToOne
CG9175 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea sec-12 35
  • 41.62 (n)
  • 29.19 (a)
sec-12 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5504 36
  • 40 (a)
OneToOne
Species with no ortholog for PREB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PREB Gene

ENSEMBL:
Gene Tree for PREB (if available)
TreeFam:
Gene Tree for PREB (if available)

Paralogs for PREB Gene

No data available for Paralogs for PREB Gene

Variants for PREB Gene

Sequence variations from dbSNP and Humsavar for PREB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2289358 -- 27,133,123(+) TTCCA(G/T)ACACG synonymous-codon, reference
rs2289359 -- 27,133,410(+) GCAGG(C/T)GCCCA intron-variant
rs4665948 -- 27,132,586(+) CCACC(A/C)CCCAA intron-variant
rs11542375 -- 27,132,347(-) AATTC(C/T)CCACA reference, missense, intron-variant
rs11542376 -- 27,134,454(-) GGTGC(C/G)GCGGT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PREB Gene

Variant ID Type Subtype PubMed ID
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897

Relevant External Links for PREB Gene

HapMap Linkage Disequilibrium report
PREB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PREB Gene

Disorders for PREB Gene

(1) MalaCards Diseases for PREB Gene

Search for PREB Gene in MalaCards »

(2) University of Copenhagen DISEASES for PREB Gene

Relevant External Links for PREB

Genetic Association Database (GAD)
PREB
Human Genome Epidemiology (HuGE) Navigator
PREB
genes like me logo Genes that share disorders with PREB: view

No data available for UniProtKB/Swiss-Prot for PREB Gene

Publications for PREB Gene

  1. The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. (PMID: 12735795) Edgar A.J. (BMC Genomics 2003) 2 3 4 23
  2. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. (PMID: 10194769) Fliss M.S. … Bancroft C. (Mol. Endocrinol. 1999) 2 3 23
  3. Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome. (PMID: 10920239) Taylor Clelland C.L. … Bancroft C. (Mamm. Genome 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PREB Gene

Sources for PREB Gene

Back to Top

Content