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PREB Gene

protein-coding   GIFtS: 61
GCID: GC02M027353

Prolactin Regulatory Element Binding

  See PREB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prolactin Regulatory Element Binding1 2
Mammalian Guanine Nucleotide Exchange Factor MSec122 3
SEC122 3
Prolactin Regulatory Binding-Element Protein2
Prolactin Regulatory Element-Binding Protein2

External Ids:    HGNC: 93561   Entrez Gene: 101132   Ensembl: ENSG000001380737   OMIM: 6063955   UniProtKB: Q9HCU53   
ORGUL members:         

Export aliases for PREB gene to outside databases

Previous GC identifers: GC02M027274 GC02M027446 GC02M027311 GC02M027328 GC02M027265 GC02M027207 GC02M027095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PREB Gene:
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter.
This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental
abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing
1 (ABHD1) gene on the opposite strand. (provided by RefSeq, Jul 2008)

GeneCards Summary for PREB Gene:
PREB (prolactin regulatory element binding) is a protein-coding gene. Diseases associated with PREB include testicular leukemia.

UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5
Function: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds
to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide
exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER

Gene Wiki entry for PREB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PREB gene promoter:
         AP-1   ATF-2   NF-kappaB   HEN1   HOXA5   STAT3   c-Jun   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPREB promoter sequence
   Search Chromatin IP Primers for PREB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PREB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23

PREB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PREB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027353:  view genomic region     (about GC identifiers)

Start:
27,353,624 bp from pter      End:
27,357,543 bp from pter
Size:
3,920 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5 (See protein sequence)
Recommended Name: Prolactin regulatory element-binding protein  
Size: 417 amino acids; 45468 Da
Subunit: Binds SARA2
Secondary accessions: Q53SZ8 Q9UH94

Explore the universe of human proteins at neXtProt for PREB: NX_Q9HCU5

Explore proteomics data for PREB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys38, Lys188, Lys209, Lys224, Lys272
  • Modification sites at PhosphoSitePlus

  • See PREB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037520.1  
    ENSEMBL proteins: 
     ENSP00000260643   ENSP00000416103   ENSP00000384032   ENSP00000397036   ENSP00000407036  
     ENSP00000391894  
    Reactome Protein details: Q9HCU5

    PREB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for PREB
    OriGene Protein Over-expression Lysate for PREB
    OriGene MassSpec for PREB
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    Novus Biologicals PREB Proteins
    Novus Biologicals PREB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PREB

     
    Search eBioscience for Proteins for PREB 

     
    antibodies-online proteins for PREB (6 products) 

     
    antibodies-online peptides for PREB

    PREB Antibody Products:

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    Abcam antibodies for PREB
    Cloud-Clone Corp. Antibodies for PREB
    Search ThermoFisher Antibodies for PREB
    antibodies-online antibodies for PREB (12 products) 

    PREB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PREB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PREB
    Cloud-Clone Corp. CLIAs for PREB
    Search eBioscience for ELISAs for PREB 
    antibodies-online kits for PREB (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCU5

    ProtoNet protein and cluster: Q9HCU5

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5
    Similarity: Contains 3 WD repeats


    Find genes that share domains with PREB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PREB_HUMAN, Q9HCU5
    Function: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds
    to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide
    exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PREB           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PREB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PREB:
    hsa-mir-183-5p (MIRT047099), hsa-mir-124-3p (MIRT022830), hsa-let-7a-5p (MIRT052602), hsa-mir-15a-5p (MIRT051323)

    Block miRNA regulation of human, mouse, rat PREB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PREB (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-198 hsa-miR-130a* hsa-miR-545 hsa-miR-23c hsa-miR-449a hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidPREB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PREB
    Predesigned siRNA for gene silencing in human, mouse, rat PREB

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PREB

    Clone
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    OriGene clones in human, mouse for PREB (see all 6)
    OriGene ORF clones in mouse, rat for PREB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PREB (NM_007128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PREB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PREB

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PREB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PREB 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PREB_HUMAN, Q9HCU5: Nucleus (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    mitochondrion2
    cytoskeleton1
    cytosol1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PREB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PREB About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1ER to Golgi Transport
    ER to Golgi Transport0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    Delta508 CFTR traffic ER to Golgi in CF0.36
    COPII (Coat Protein 2) Mediated Vesicle Transport0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Transport to the Golgi and subsequent modification0.40
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    3Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    4Clathrin dependent protein traffic
    Transport Clathrin coated vesicle cycle0.66
    5Clathrin derived vesicle budding
    Membrane Trafficking0.32


    Find genes that share SuperPaths with PREB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for PREB
        Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    2 Reactome Pathways for PREB
        XBP1(S) activates chaperone genes
    COPII (Coat Protein 2) Mediated Vesicle Transport


    1 Kegg Pathway  (Kegg details for PREB):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PREB
    Interactions:

        GeneGlobe Interaction Network for PREB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PREB (Q9HCU53 ENSP000002606434) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1EP496743, ENSP000003529294I2D: score=1 STRING: ENSP00000352929
    TRIP13Q156453, ENSP000001663454I2D: score=1 STRING: ENSP00000166345
    SMAD1Q157973, ENSP000003057694I2D: score=3 STRING: ENSP00000305769
    TGFBR1P368973, ENSP000003641334I2D: score=4 STRING: ENSP00000364133
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006888ER to Golgi vesicle-mediated transport TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with PREB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PREB

    3 HMDB Compounds for PREB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PREB gene: 
    NM_013388.4  

    Unigene Cluster for PREB:

    Prolactin regulatory element binding
    Hs.279784  [show with all ESTs]
    Unigene Representative Sequence: BC036185
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468045 ENST00000260643(uc002rix.1 uc002riy.1) ENST00000444452
    ENST00000406567 ENST00000456259 ENST00000430533 ENST00000441451 ENST00000474802
    ENST00000416802
    miRNA
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    Block miRNA regulation of human, mouse, rat PREB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PREB (see all 11):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-198 hsa-miR-130a* hsa-miR-545 hsa-miR-23c hsa-miR-449a hsa-miR-34a
    SwitchGear 3'UTR luciferase reporter plasmidPREB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PREB
    Predesigned siRNA for gene silencing in human, mouse, rat PREB
    Clone
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    OriGene clones in human, mouse for PREB (see all 6)
    OriGene ORF clones in mouse, rat for PREB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PREB (NM_007128)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PREB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PREB
    Primer
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    OriGene qPCR primer pairs and template standards for PREB
    OriGene qSTAR qPCR primer pairs in human, mouse for PREB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PREB
      QuantiTect SYBR Green Assays in human, mouse, rat PREB
      QuantiFast Probe-based Assays in human, mouse, rat PREB

    Additional mRNA sequence: 

    AF203687.1 AF226684.1 AK001976.1 AK023064.1 AK023405.1 AK292178.1 BC002765.2 BC008658.1 
    BC012890.1 BC016472.1 BC016906.1 BC036185.1 BC041032.1 

    17 DOTS entries:

    DT.95309112  DT.443424  DT.101985109  DT.97849854  DT.100877093  DT.91773209  DT.121009821  DT.95368732 
    DT.121009859  DT.95368742  DT.97849847  DT.100030138  DT.100877118  DT.121009844  DT.121009850  DT.121009858 
    DT.95155684 

    Selected AceView cDNA sequences (see all 404):

    BG913621 CR622322 AW402477 AA687138 BQ058349 NM_013388 BC002765 AI689551 
    AA300144 BQ645562 BU169223 BP363839 BC012890 AU280660 CR610473 BQ065666 
    AI150987 BQ425317 BU741412 AI539838 AI085749 BC008658 BC016472 BM126395 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PREB (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
    SP1:                                      -                             -                                                     -     -     -                     
    SP2:                                                                    -                                                     -                                 
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                          -                                 
    SP5:                                                                    -                                                                                       

    ExUns: 11b ^ 12a · 12b · 12c
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PREB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PREB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCCCTGG
    PREB Expression
    About this image


    PREB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PREB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PREB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279784

    UniProtKB/Swiss-Prot: PREB_HUMAN, Q9HCU5
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for PREB
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PREB
    QuantiTect SYBR Green Assays in human, mouse, rat PREB
    QuantiFast Probe-based Assays in human, mouse, rat PREB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PREB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for PREB gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Preb1 , 5 prolactin regulatory element binding1, 5 87.05(n)1
    88.73(a)1
      5 (16.90 cM)5
    509071  NM_016703.21  NP_057912.21 
     309508535 
    chicken
    (Gallus gallus)
    Aves PREB1 prolactin regulatory element binding 70.4(n)
    71.98(a)
      100858986  XM_003643516.2  XP_003643564.1 
    lizard
    (Anolis carolinensis)
    Reptilia PREB6
    prolactin regulatory element binding
    53(a)
    1 ↔ 1
    AAWZ02041606(3881-5460)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX846331.12   -- 71.98(n)    BX846331.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb3852 sbcb385 75.57(n)   368318  CF348612.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91751 , 3 DNA binding3
    CG91751
    32(a)3
    48.05(n)1
    35.16(a)1
      26B93
    338621  NM_135151.41  NP_608995.21 
    worm
    (Caenorhabditis elegans)
    Secernentea sec-121 sec-12 41.62(n)
    29.19(a)
      172641  NM_059904.4  NP_492305.2 


    ENSEMBL Gene Tree for PREB (if available)
    TreeFam Gene Tree for PREB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PREB (see all 174)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127065551,2
    C,F--27277243(+) AGCTGC/TGGACC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs739214571,2
    C--27277254(+) CGAATG/AGAGTG 1 -- ut312Minor allele frequency- A:0.04WA 120
    rs612767761,2
    C,F--27277361(+) GCACTC/TTGGAG 2 Q syn13Minor allele frequency- T:0.01WA NA 3514
    rs1403182871,2
    C--27277409(+) AGGAGC/GAGGAG 2 L syn11Minor allele frequency- G:0.00NA 3706
    rs1395509731,2
    C,F--27277412(+) AGCAGG/AAGCCA 2 /L syn11Minor allele frequency- A:0.00NA 3698
    rs745512041,2
    C,F--27277427(+) GGAACA/GCTCCC 2 S syn12Minor allele frequency- G:0.02WA NA 3702
    rs116956411,2
    C,F,H--27277474(+) GGCTTC/TCCAGC 1 -- int12Minor allele frequency- T:0.13NA EU 569
    rs1153456521,2
    F--27277525(+) GCCCAG/ACCTCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs2002881651,2
    C--27277560(+) ACGTGA/GGGTGG 1 -- int10--------
    rs1998265711,2
    C--27277595(+) CTCACA/GCCGTG 2 R W mis10--------

    HapMap Linkage Disequilibrium report for PREB (27353624 - 27357543 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PREB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833603CNV Loss17160897
    nsv817673CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PREB
    DNA2.0 Custom Variant and Variant Library Synthesis for PREB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606395    OMIM disorders: --

    1 disease for PREB:    
    About MalaCards
    testicular leukemia

    2 diseases from the University of Copenhagen DISEASES database for PREB:
    Leukemia     Testicular leukemia

    Find genes that share disorders with PREB           About GenesLikeMe

    Genetic Association Database (GAD): PREB
    Human Genome Epidemiology (HuGE) Navigator: PREB (3 documents)

    Export disorders for PREB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PREB gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with PREB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. (PubMed id 12735795)1, 2, 3, 9 Edgar A.J. (BMC Genomics 2003)
    2. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. (PubMed id 10194769)1, 3, 9 Fliss M.S....Bancroft C. (Mol. Endocrinol. 1999)
    3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Cloning and characterization of human PREB; a gene that maps to a genomic region associated with trisomy 2p syndrome. (PubMed id 10920239)1, 2 Taylor Clelland C.L.... Bancroft C. (Mamm. Genome 2000)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10113 HGNC: 9356 AceView: PREB Ensembl:ENSG00000138073 euGenes: HUgn10113
    ECgene: PREB Kegg: 10113 H-InvDB: PREB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PREB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PREB gene:
    Search GeneIP for patents involving PREB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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