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Aliases for PREB Gene

Aliases for PREB Gene

  • Prolactin Regulatory Element Binding 2 3 5
  • Mammalian Guanine Nucleotide Exchange Factor MSec12 3 4
  • SEC12 3 4
  • Prolactin Regulatory Binding-Element Protein 3

External Ids for PREB Gene

Previous GeneCards Identifiers for PREB Gene

  • GC02M027274
  • GC02M027446
  • GC02M027311
  • GC02M027328
  • GC02M027265
  • GC02M027207
  • GC02M027353
  • GC02M027095

Summaries for PREB Gene

Entrez Gene Summary for PREB Gene

  • This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

GeneCards Summary for PREB Gene

PREB (Prolactin Regulatory Element Binding) is a Protein Coding gene. Diseases associated with PREB include testicular leukemia. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR).

UniProtKB/Swiss-Prot for PREB Gene

  • Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

Gene Wiki entry for PREB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PREB Gene

Genomics for PREB Gene

Regulatory Elements for PREB Gene

Promoters for PREB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PREB on UCSC Golden Path with GeneCards custom track

Genomic Location for PREB Gene

Chromosome:
2
Start:
27,130,756 bp from pter
End:
27,134,675 bp from pter
Size:
3,920 bases
Orientation:
Minus strand

Genomic View for PREB Gene

Genes around PREB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PREB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PREB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PREB Gene

Proteins for PREB Gene

  • Protein details for PREB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCU5-PREB_HUMAN
    Recommended name:
    Prolactin regulatory element-binding protein
    Protein Accession:
    Q9HCU5
    Secondary Accessions:
    • Q53SZ8
    • Q9UH94

    Protein attributes for PREB Gene

    Size:
    417 amino acids
    Molecular mass:
    45468 Da
    Quaternary structure:
    • Binds SARA2.

neXtProt entry for PREB Gene

Proteomics data for PREB Gene at MOPED

Post-translational modifications for PREB Gene

  • Ubiquitination at Lys 38, Lys 188, Lys 209, Lys 224, and Lys 272
  • Modification sites at PhosphoSitePlus

Other Protein References for PREB Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PREB

No data available for DME Specific Peptides for PREB Gene

Domains & Families for PREB Gene

Gene Families for PREB Gene

Protein Domains for PREB Gene

Suggested Antigen Peptide Sequences for PREB Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCU5

UniProtKB/Swiss-Prot:

PREB_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PREB: view

Function for PREB Gene

Molecular function for PREB Gene

UniProtKB/Swiss-Prot Function:
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.
genes like me logo Genes that share phenotypes with PREB: view

Animal Model Products

miRNA for PREB Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PREB Gene

Localization for PREB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PREB Gene

Nucleus. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PREB Gene COMPARTMENTS Subcellular localization image for PREB gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
mitochondrion 2
plasma membrane 2
vacuole 2
cytoskeleton 1
cytosol 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PREB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with PREB: view

Pathways & Interactions for PREB Gene

genes like me logo Genes that share pathways with PREB: view

Gene Ontology (GO) - Biological Process for PREB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PREB: view

No data available for SIGNOR curated interactions for PREB Gene

Drugs & Compounds for PREB Gene

(3) Drugs for PREB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PREB: view

Transcripts for PREB Gene

Unigene Clusters for PREB Gene

Prolactin regulatory element binding:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PREB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - -
SP7:
SP8: - -
SP9:
SP10: -
SP11: -
SP12: - - - - - -
SP13: - -

ExUns: 11b ^ 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for PREB Gene

GeneLoc Exon Structure for
PREB
ECgene alternative splicing isoforms for
PREB

Expression for PREB Gene

mRNA expression in normal human tissues for PREB Gene

Protein differential expression in normal tissues from HIPED for PREB Gene

This gene is overexpressed in Nasal epithelium (21.3) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PREB Gene



SOURCE GeneReport for Unigene cluster for PREB Gene Hs.279784

mRNA Expression by UniProt/SwissProt for PREB Gene

Q9HCU5-PREB_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PREB: view

Protein tissue co-expression partners for PREB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PREB Gene

Orthologs for PREB Gene

This gene was present in the common ancestor of animals.

Orthologs for PREB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PREB 35
  • 90.89 (n)
  • 92.81 (a)
PREB 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PREB 35
  • 91.53 (n)
  • 93.05 (a)
PREB 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Preb 35
  • 87.05 (n)
  • 88.73 (a)
Preb 16
Preb 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PREB 35
  • 99.76 (n)
  • 99.52 (a)
PREB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Preb 35
  • 87.61 (n)
  • 89.45 (a)
oppossum
(Monodelphis domestica)
Mammalia PREB 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PREB 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PREB 35
  • 70.4 (n)
  • 71.98 (a)
PREB 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PREB 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia preb 35
  • 64.99 (n)
  • 61.63 (a)
Str.2368 35
zebrafish
(Danio rerio)
Actinopterygii preb 35
  • 60.11 (n)
  • 58.27 (a)
sbcb385 35
preb 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9088 35
fruit fly
(Drosophila melanogaster)
Insecta CG9175 37
  • 32 (a)
CG9175 35
  • 48.05 (n)
  • 35.16 (a)
CG9175 36
  • 32 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009942 35
  • 48.18 (n)
  • 36.39 (a)
worm
(Caenorhabditis elegans)
Secernentea sec-12 35
  • 41.62 (n)
  • 29.19 (a)
sec-12 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5504 36
  • 40 (a)
OneToOne
Species with no ortholog for PREB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PREB Gene

ENSEMBL:
Gene Tree for PREB (if available)
TreeFam:
Gene Tree for PREB (if available)

Paralogs for PREB Gene

No data available for Paralogs for PREB Gene

Variants for PREB Gene

Sequence variations from dbSNP and Humsavar for PREB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2289358 -- 27,133,123(+) TTCCA(C/G/T)ACACG nc-transcript-variant, reference, synonymous-codon
rs2289359 -- 27,133,410(+) GCAGG(C/G/T)GCCCA intron-variant
rs4665948 -- 27,132,586(+) CCACC(A/C)CCCAA intron-variant
rs11678061 -- 27,134,751(+) TCCAC(C/T)CCTGG upstream-variant-2KB
rs11542375 -- 27,132,347(-) AATTC(C/T)CCACA intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PREB Gene

Variant ID Type Subtype PubMed ID
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897

Variation tolerance for PREB Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PREB Gene

HapMap Linkage Disequilibrium report
PREB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PREB Gene

Disorders for PREB Gene

MalaCards: The human disease database

(1) MalaCards diseases for PREB Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards
Search PREB in MalaCards View complete list of genes associated with diseases

Relevant External Links for PREB

Genetic Association Database (GAD)
PREB
Human Genome Epidemiology (HuGE) Navigator
PREB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PREB
genes like me logo Genes that share disorders with PREB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PREB Gene

Publications for PREB Gene

  1. The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12. (PMID: 12735795) Edgar A.J. (BMC Genomics 2003) 2 3 4 23 67
  2. Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity. (PMID: 10194769) Fliss M.S. … Bancroft C. (Mol. Endocrinol. 1999) 2 3 23
  3. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3
  4. Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export. (PMID: 25202031) Saito K. … Katada T. (J. Cell Biol. 2014) 3
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3

Products for PREB Gene

Sources for PREB Gene

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