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Aliases for PRDX6 Gene

Aliases for PRDX6 Gene

  • Peroxiredoxin 6 2 3 5
  • Acidic Calcium-Independent Phospholipase A2 3 4
  • Non-Selenium Glutathione Peroxidase 3 4
  • Red Blood Cells Page Spot 12 3 4
  • Antioxidant Protein 2 3 4
  • Liver 2D Page Spot 40 3 4
  • 1-Cys Peroxiredoxin 3 4
  • 24 KDa Protein 3 4
  • EC 1.11.1.15 4 63
  • 1-Cys PRX 3 4
  • AiPLA2 3 4
  • NSGPx 3 4
  • AOP2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 128m 3
  • EC 1.11.1.9 4
  • HEL-S-128m 3
  • EC 3.1.1.- 4
  • KIAA0106 4
  • 1-Cys 3
  • PRX 3
  • P29 3

External Ids for PRDX6 Gene

Previous GeneCards Identifiers for PRDX6 Gene

  • GC01P169075
  • GC01P170027
  • GC01P170685
  • GC01P170178
  • GC01P171713
  • GC01P173446
  • GC01P144671

Summaries for PRDX6 Gene

Entrez Gene Summary for PRDX6 Gene

  • The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX6 Gene

PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include fuchs' endothelial dystrophy and gnathomiasis. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include oxidoreductase activity and antioxidant activity.

UniProtKB/Swiss-Prot for PRDX6 Gene

  • Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Gene Wiki entry for PRDX6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX6 Gene

Genomics for PRDX6 Gene

Regulatory Elements for PRDX6 Gene

Promoters for PRDX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRDX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRDX6 Gene

Chromosome:
1
Start:
173,477,266 bp from pter
End:
173,488,807 bp from pter
Size:
11,542 bases
Orientation:
Plus strand

Genomic View for PRDX6 Gene

Genes around PRDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX6 Gene

Proteins for PRDX6 Gene

  • Protein details for PRDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30041-PRDX6_HUMAN
    Recommended name:
    Peroxiredoxin-6
    Protein Accession:
    P30041
    Secondary Accessions:
    • A8JZY7
    • P32077
    • Q5TAH4
    • Q5ZEZ8

    Protein attributes for PRDX6 Gene

    Size:
    224 amino acids
    Molecular mass:
    25035 Da
    Quaternary structure:
    • Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B.
    Miscellaneous:
    • Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.
    • The active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6 conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly reduced to cysteine by glutathione and not thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX6 Gene

neXtProt entry for PRDX6 Gene

Proteomics data for PRDX6 Gene at MOPED

Selected DME Specific Peptides for PRDX6 Gene

Post-translational modifications for PRDX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRDX6 (Peroxiredoxin 6)

Domains & Families for PRDX6 Gene

Gene Families for PRDX6 Gene

Suggested Antigen Peptide Sequences for PRDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30041

UniProtKB/Swiss-Prot:

PRDX6_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the AhpC/TSA family. Rehydrin subfamily.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the AhpC/TSA family. Rehydrin subfamily.
genes like me logo Genes that share domains with PRDX6: view

Function for PRDX6 Gene

Molecular function for PRDX6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Enzyme Numbers (IUBMB) for PRDX6 Gene

Gene Ontology (GO) - Molecular Function for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PRDX6: view
genes like me logo Genes that share phenotypes with PRDX6: view

Animal Models for PRDX6 Gene

MGI Knock Outs for PRDX6:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX6

miRNA for PRDX6 Gene

miRTarBase miRNAs that target PRDX6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX6 Gene

Localization for PRDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX6 Gene

Cytoplasm. Lysosome. Cytoplasmic vesicle. Note=Also found in lung secretory organelles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX6 Gene COMPARTMENTS Subcellular localization image for PRDX6 gene
Compartment Confidence
cytosol 5
extracellular 5
lysosome 4
vacuole 4
mitochondrion 3
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19188445
genes like me logo Genes that share ontologies with PRDX6: view

Pathways & Interactions for PRDX6 Gene

genes like me logo Genes that share pathways with PRDX6: view

Pathways by source for PRDX6 Gene

1 KEGG pathway for PRDX6 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX6 Gene

SIGNOR curated interactions for PRDX6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA --
GO:0042744 hydrogen peroxide catabolic process IEA --
GO:0098869 cellular oxidant detoxification IEA,NAS --
genes like me logo Genes that share ontologies with PRDX6: view

Drugs & Compounds for PRDX6 Gene

(12) Drugs for PRDX6 Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra 0
L-Phenylalanine Approved Nutra 0
2-(N-Morpholino)-Ethanesulfonic Acid Experimental Pharma Target 0
4-hydroxycoumarin Experimental Pharma 0
Formaldehyde Experimental Pharma 73

(26) Additional Compounds for PRDX6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
2-Phenylacetamide
  • (alpha-)2-Phenylacetamide
  • 2-Phenyl-Acetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • alpha-Toluimidic acid
103-81-1
5-Hydroxyconiferyl alcohol
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
Coniferyl alcohol
  • (E) 3-(4-hydroxy-3-methoxyphenyl)-2-Propen-1-ol
  • 3-(4-Hydroxy-3-methoxyphenyl)-2-Propen-1-ol
  • 3-(4-Hydroxy-3-methoxyphenyl)allyl alcohol
  • 4-((1E)-3-Hydroxy-1-propenyl)-2-methoxyphenol
  • 4-(3-Hydroxy-1-propenyl)-2-methoxy-Phenol
458-35-5
genes like me logo Genes that share compounds with PRDX6: view

Transcripts for PRDX6 Gene

mRNA/cDNA for PRDX6 Gene

Unigene Clusters for PRDX6 Gene

Peroxiredoxin 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX6 Gene

No ASD Table

Relevant External Links for PRDX6 Gene

GeneLoc Exon Structure for
PRDX6
ECgene alternative splicing isoforms for
PRDX6

Expression for PRDX6 Gene

mRNA expression in normal human tissues for PRDX6 Gene

mRNA differential expression in normal tissues according to GTEx for PRDX6 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX6 Gene



SOURCE GeneReport for Unigene cluster for PRDX6 Gene Hs.120

genes like me logo Genes that share expression patterns with PRDX6: view

Protein tissue co-expression partners for PRDX6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDX6 Gene

Orthologs for PRDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
PRDX6 35
  • 99.7 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PRDX6 36
  • 95 (a)
OneToOne
PRDX6 35
  • 92.86 (n)
  • 95.09 (a)
dog
(Canis familiaris)
Mammalia PRDX6 35
  • 91.52 (n)
  • 92.86 (a)
PRDX6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdx6 16
Prdx6 35
  • 87.35 (n)
  • 89.73 (a)
Prdx6 36
  • 90 (a)
OneToMany
Prdx6b 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PRDX6 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX6 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx6 35
  • 88.84 (n)
  • 91.52 (a)
chicken
(Gallus gallus)
Aves PRDX6 35
  • 77.98 (n)
  • 86.43 (a)
PRDX6 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX6 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76137 35
prdx6 35
  • 71.04 (n)
  • 76.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
prdx6 35
  • 67.27 (n)
  • 73.64 (a)
prdx6 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TPX5 35
  • 59.73 (n)
  • 60.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12896 36
  • 52 (a)
OneToMany
Prx2540-1 36
  • 53 (a)
OneToMany
Prx2540-2 36
  • 53 (a)
OneToMany
Prx6005 36
  • 61 (a)
OneToMany
Prx6005 35
  • 58.87 (n)
  • 61.01 (a)
worm
(Caenorhabditis elegans)
Secernentea prdx-6 36
  • 47 (a)
OneToOne
prdx-6 35
  • 55.56 (n)
  • 52.38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR368W 35
  • 55.45 (n)
  • 50.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRX1 35
  • 54.81 (n)
  • 50.96 (a)
PRX1 36
  • 41 (a)
OneToOne
PRX1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20285g 35
  • 54.65 (n)
  • 48.56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PER1 35
  • 55.77 (n)
  • 52.61 (a)
rice
(Oryza sativa)
Liliopsida Os07g0638400 35
  • 56.53 (n)
  • 53.92 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06031 35
  • 58.73 (n)
  • 53.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4007 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10477 36
  • 55 (a)
OneToOne
Species with no ortholog for PRDX6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX6 Gene

ENSEMBL:
Gene Tree for PRDX6 (if available)
TreeFam:
Gene Tree for PRDX6 (if available)

Paralogs for PRDX6 Gene

(1) SIMAP similar genes for PRDX6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PRDX6 Gene

genes like me logo Genes that share paralogs with PRDX6: view

No data available for Paralogs for PRDX6 Gene

Variants for PRDX6 Gene

Sequence variations from dbSNP and Humsavar for PRDX6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs4611 -- 173,487,878(+) AGAAG(C/T)TGGTG utr-variant-3-prime
rs3211528 -- 173,488,439(+) TGGGG(A/G)AAAAA utr-variant-3-prime
rs7542869 -- 173,484,160(+) tatat(A/T)tatat intron-variant
rs9425723 -- 173,479,356(+) TTTAT(A/G)ACACA intron-variant
rs9425724 -- 173,479,361(+) AACAC(A/G)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX6 Gene

Variant ID Type Subtype PubMed ID
nsv831915 CNV Gain+Loss 17160897

Variation tolerance for PRDX6 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX6 Gene

HapMap Linkage Disequilibrium report
PRDX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX6 Gene

Disorders for PRDX6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRDX6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
gnathomiasis
  • gnathostomiasis
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search PRDX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX6

Genetic Association Database (GAD)
PRDX6
Human Genome Epidemiology (HuGE) Navigator
PRDX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX6
genes like me logo Genes that share disorders with PRDX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX6 Gene

Publications for PRDX6 Gene

  1. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PMID: 10893423) Chen J.-W. … Fisher A.B. (J. Biol. Chem. 2000) 3 4 23 67
  2. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PMID: 11233154) Phelan S.A. (Antioxid. Redox Signal. 1999) 2 3 23
  3. Phospholipase A2 activity of peroxiredoxin 6 promotes invasion and metastasis of lung cancer cells. (PMID: 20354123) Ho J.N. … Um H.D. (Mol. Cancer Ther. 2010) 3 23
  4. Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. (PMID: 18973804) Chowdhury I. … Feinstein S.I. (Free Radic. Biol. Med. 2009) 3 23
  5. Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities. (PMID: 19236840) Manevich Y. … Fisher A.B. (Arch. Biochem. Biophys. 2009) 3 23

Products for PRDX6 Gene

Sources for PRDX6 Gene

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