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PRDX6 Gene

protein-coding   GIFtS: 71
GCID: GC01P173446

Peroxiredoxin 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxiredoxin 61 2     aiPLA22 3
Acidic Calcium-Independent Phospholipase A22 3     EC 1.11.1.153 8
Antioxidant Protein 22 3     1-Cys2
Liver 2D Page Spot 402 3     HEL-S-128m2
Non-Selenium Glutathione Peroxidase2 3     PRX2
Red Blood Cells Page Spot 122 3     Epididymis Secretory Sperm Binding Protein Li 128m2
1-Cys Peroxiredoxin2 3     p292
1-Cys PRX2 3     peroxiredoxin-62
24 KDa Protein2 3     EC 1.11.1.93
AOP22 3     EC 3.1.1.-3
NSGPx2 3     KIAA01063

External Ids:    HGNC: 167531   Entrez Gene: 95882   Ensembl: ENSG000001175927   OMIM: 6023165   UniProtKB: P300413   

Export aliases for PRDX6 gene to outside databases

Previous GC identifers: GC01P169075 GC01P170027 GC01P170685 GC01P170178 GC01P171713 GC01P144671


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRDX6 Gene:
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a
bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce
H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the
regulation of phospholipid turnover as well as in protection against oxidative injury. (provided by RefSeq, Jul
2008)

GeneCards Summary for PRDX6 Gene:
PRDX6 (peroxiredoxin 6) is a protein-coding gene. Diseases associated with PRDX6 include gnathomiasis, and chancroid. GO annotations related to this gene include glutathione peroxidase activity and antioxidant activity.

UniProtKB/Swiss-Prot: PRDX6_HUMAN, P30041
Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and
phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection
against oxidative injury

Gene Wiki entry for PRDX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDX6 gene promoter:
         MEF-2A   C/EBPbeta   STAT1   AML1a   MEF-2   Pax-2   aMEF-2   Pax-2a   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRDX6 promoter sequence
   Search Chromatin IP Primers for PRDX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q24.1

PRDX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P173446:  view genomic region     (about GC identifiers)

Start:
173,446,405 bp from pter      End:
173,457,946 bp from pter
Size:
11,542 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRDX6_HUMAN, P30041 (See protein sequence)
Recommended Name: Peroxiredoxin-6  
Size: 224 amino acids; 25035 Da
Subunit: Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with
HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B
Miscellaneous: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6
conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly
reduced to cysteine by glutathione and not thioredoxin
Miscellaneous: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress
1 PDB 3D structure from and Proteopedia for PRDX6:
1PRX (3D)    
Secondary accessions: A8JZY7 P32077 Q5TAH4 Q5ZEZ8

Explore the universe of human proteins at neXtProt for PRDX6: NX_P30041

Explore proteomics data for PRDX6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys209
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for PRDX6 (P30041)
     VATPVDWK  TTGRNFDE  DFTPVCTTEL 


    See PRDX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004896.1  
    ENSEMBL proteins: 
     ENSP00000342026  
    Reactome Protein details: P30041

    PRDX6 Human Recombinant Protein Products:

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    OriGene Purified Proteins for PRDX6
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    OriGene MassSpec for PRDX6
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    Novus Biologicals PRDX6 Proteins
    Novus Biologicals PRDX6 Lysate
    Sino Biological Recombinant Protein for PRDX6
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRDX6
    Cloud-Clone Corp. Proteins for PRDX6

    PRDX6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX6
    R&D Systems Antibodies for PRDX6 (Peroxiredoxin 6)
    OriGene Antibodies for PRDX6
    OriGene Custom Antibody Services for PRDX6
    Novus Biologicals PRDX6 Antibodies
    Abcam antibodies for PRDX6
    Cloud-Clone Corp. Antibodies for PRDX6
    ThermoFisher Antibody for PRDX6
    LSBio Antibodies in human, mouse, rat for PRDX6

    PRDX6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PRDX6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRDX6
    Cloud-Clone Corp. CLIAs for PRDX6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry P30041

    ProtoNet protein and cluster: P30041

    1 Blocks protein domain: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX6_HUMAN, P30041
    Similarity: Belongs to the AhpC/TSA family. Rehydrin subfamily
    Similarity: Contains 1 thioredoxin domain


    PRDX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX6_HUMAN, P30041
    Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and
    phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection
    against oxidative injury
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

         Enzyme Numbers (IUBMB): EC 1.11.1.151 2 EC 1.11.1.91 EC 3.1.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602glutathione peroxidase activity IEA--
    GO:0004623phospholipase A2 activity IDA10893423
    GO:0005515protein binding IPI19188445
    GO:0016209antioxidant activity NAS10893423
    GO:0016491oxidoreductase activity ----
         
    PRDX6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRDX6:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prdx6):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  liver/biliary system 
     normal  other  renal/urinary system  respiratory system  vision/eye 

    PRDX6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prdx6tm1Abf for PRDX6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRDX6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRDX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX6

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRDX6:
    hsa-mir-320a (MIRT044389), hsa-mir-632 (MIRT004940)

    Block miRNA regulation of human, mouse, rat PRDX6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRDX6 (see all 9):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-124 hsa-miR-149 hsa-miR-186 hsa-miR-506 hsa-miR-24 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPRDX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRDX6
    Predesigned siRNA for gene silencing in human, mouse, rat PRDX6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRDX6

    Clone
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    OriGene clones in human, mouse for PRDX6 (see all 6)
    OriGene ORF clones in mouse, rat for PRDX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRDX6 (NM_004905)
    Sino Biological Human cDNA Clone for PRDX6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRDX6_HUMAN, P30041: Cytoplasm. Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Also found in
    lung secretory organelles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus3
    plasma membrane3
    cytoskeleton2
    lysosome2
    mitochondrion2
    vacuole2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IDA19188445
    GO:0005764lysosome IEA--
    GO:0005829cytosol TAS--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    PRDX6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRDX6 About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular responses to stress0.81
    2Metabolism
    Metabolic pathways0.38
    3Phenylalanine metabolism
    Phenylalanine metabolism0.36
    4Immune response Role of DAP12 receptors in NK cells
    Immune response CD16 signaling in NK cells0.33
    5Detoxification of Reactive Oxygen Species
    Detoxification of Reactive Oxygen Species

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PRDX6
        Immune response CD16 signaling in NK cells


    1 Reactome Pathway for PRDX6
        Detoxification of Reactive Oxygen Species


    2 Kegg Pathways  (Kegg details for PRDX6):
        Phenylalanine metabolism
    Metabolic pathways


    PRDX6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRDX6: 
              Amino Acid Metabolism II in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRDX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRDX6 (P300411, 2, 3 ENSP000003420264) via UniProtKB, MINT, STRING, and/or I2D (see all 148)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120042, 3MINT-7995228 I2D: score=2 
    MAP3K4Q9Y6R43, ENSP000003759864I2D: score=3 STRING: ENSP00000375986
    NCF2P198783, ENSP000003565054I2D: score=3 STRING: ENSP00000356505
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    GABARAPL1Q9H0R83, ENSP000002664584I2D: score=1 STRING: ENSP00000266458
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress IDA10893423
    GO:0009395phospholipid catabolic process IDA10893423
    GO:0042744hydrogen peroxide catabolic process IEA--
    GO:0055114oxidation-reduction process ----

    PRDX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDX6

    10 HMDB Compounds for PRDX6    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-PhenylacetamideBenzeneacetamide (see all 10)103-81-1--
    4-Coumaryl alcohol3-(4-Hydroxyphenyl)-1-propane (see all 12)1076-38-6--
    Cyanosulfurous acid anionCNSu;cyanosulfurous acid ----
    FormaldehydeAldeide formica (see all 16)50-00-0--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    HypothiocyaniteCyanosulfoxylate;Hypothiocyanite;OSCN-Hypothiocyanite ion;N,6-didehydro-3,6-dihydro-3-methyl-Adenosine 63296-34-4--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    MethanolAlcool methylique (see all 23)67-56-1--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PRDX6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for PRDX6 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine sulfinic acid 88.2 6 17176052 (3), 17653208 (1), 15952770 (1), 19176523 (1)
    sulfinic acid 84.5 4 19812042 (1), 18593714 (1), 15917647 (1)
    mj 33 76.6 10 9787801 (1), 10893423 (1)
    mercaptosuccinic acid 70 3 12144348 (1), 10893423 (1)
    cysteine 65.4 40 11832487 (3), 9497358 (2), 16916801 (2), 18084891 (2) (see all 23)
    h2o2 64.5 14 9497358 (2), 11771746 (1), 16401067 (1), 20138108 (1) (see all 12)
    glyceraldehyde 3-phosphate 46.7 15 19737146 (6), 18647502 (1), 15590625 (1), 16707281 (1) (see all 6)
    oxygen 42.7 15 16539693 (1), 17026836 (1), 18386021 (1), 18184874 (1) (see all 9)
    nadph 36.4 6 19345687 (2), 19825629 (1)
    phospholipid 34.2 10 17652308 (3), 12151315 (1), 9787801 (1), 12193653 (1) (see all 6)



    PRDX6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRDX6 gene: 
    NM_004905.2  

    Unigene Cluster for PRDX6:

    Peroxiredoxin 6
    Hs.120  [show with all ESTs]
    Unigene Representative Sequence: NM_004905
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340385(uc001giy.1) ENST00000460950 ENST00000470017

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PRDX6 (see all 9):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-124 hsa-miR-149 hsa-miR-186 hsa-miR-506 hsa-miR-24 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPRDX6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PRDX6
    Predesigned siRNA for gene silencing in human, mouse, rat PRDX6
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    GenScript: all cDNA clones in your preferred vector: PRDX6 (NM_004905)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX6
    Primer
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    OriGene qPCR primer pairs and template standards for PRDX6
    OriGene qSTAR qPCR primer pairs in human, mouse for PRDX6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDX6
      QuantiTect SYBR Green Assays in human, mouse, rat PRDX6
      QuantiFast Probe-based Assays in human, mouse, rat PRDX6

    Additional mRNA sequence: 

    AJ844621.1 AK289352.1 AK300680.1 BC025421.2 BC035857.1 BC053550.1 D14662.1 EF036493.1 

    Selected DOTS entries (see all 39):

    DT.92044153  DT.100864306  DT.453489  DT.91894522  DT.100862986  DT.100862984  DT.100862959  DT.100862957 
    DT.100862964  DT.121364953  DT.102835811  DT.102835812  DT.100862979  DT.100862983  DT.91916530  DT.92033628 
    DT.100862967  DT.121364926  DT.70101606  DT.121364916  DT.100805379  DT.100862965  DT.100862975  DT.121267617 

    Selected AceView cDNA sequences (see all 1202):

    BM844686 CR623331 BU627472 N42895 AI269287 CR600822 AU120239 BM564639 
    CD674158 AU123127 BM761559 AA417670 W76457 AL710987 R80271 BQ924360 
    BM455472 CR621206 F36683 N45580 BM696845 BE794292 AA035183 AI401089 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRDX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGAGAAG
    PRDX6 Expression
    About this image


    PRDX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    PRDX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDX6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.120
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRDX6: 
              Amino Acid Metabolism II in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRDX6
    OriGene qSTAR qPCR primer pairs in human, mouse for PRDX6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDX6
    QuantiTect SYBR Green Assays in human, mouse, rat PRDX6
    QuantiFast Probe-based Assays in human, mouse, rat PRDX6
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRDX6 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx61 , 5 peroxiredoxin 61, 5 87.35(n)1
    89.73(a)1
      1 (69.75 cM)5
    117581  NM_007453.31  NP_031479.11 
     1612401125 
    chicken
    (Gallus gallus)
    Aves PRDX61 peroxiredoxin 6 77.98(n)
    86.43(a)
      429062  NM_001039329.2  NP_001034418.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX66
    peroxiredoxin 6
    81(a)
    1 ↔ 1
    4(71284129-71304057)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054278.12   -- 80.51(n)    BC054278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059671.12   -- 78.69(n)   393778  BC059671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Prx60051 Peroxiredoxin 6005 58.87(n)
    61.01(a)
      33493  NM_078739.3  NP_523463.2 
    worm
    (Caenorhabditis elegans)
    Secernentea prdx-61 prdx-6 55.56(n)
    52.38(a)
      176837  NM_171241.3  NP_741287.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRX1(YBL064C)4
    PRX11
    Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin more4
    PRX11
    54.81(n)1
    50.96(a)1
      2(101156-100371)4
    8522151, 4  NP_009489.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PER11 PER1 55.77(n)
    52.61(a)
      841231  NM_103709.3  NP_175247.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06384001 Os07g0638400 56.53(n)
    53.92(a)
      4344046  NM_001066943.1  NP_001060408.1 


    ENSEMBL Gene Tree for PRDX6 (if available)
    TreeFam Gene Tree for PRDX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRDX6 gene
    1 SIMAP similar gene for PRDX6 using alignment to 1 protein entry:     PRDX6_HUMAN:
    PRDX1

    PRDX6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRDX6
    PGOHUM00000239899 PGOHUM00000246159


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRDX6 (see all 250)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94257231,2
    C,F,A,H--173448495(+) TTTATG/AACACA 1 -- int116Minor allele frequency- A:0.47NS NA WA CSA EA 565
    rs94257241,2
    C,F,A,H--173448500(+) AACACA/GTGGAT 1 -- int116Minor allele frequency- G:0.50NS NA WA CSA EA 563
    rs1833193221,2
    --173448593(+) GAAAAA/CATTAA 1 -- int10--------
    rs1459861781,2
    --173448637(+) AAACAA/GCTAAA 1 -- int10--------
    rs3732527821,2
    C--173448897(+) CCAAGC/G/TAAGAC 1 -- int10--------
    rs1398923901,2
    --173448973(+) AGGACA/GTGAAC 1 -- int10--------
    rs75400651,2
    C,F,A,H--173449036(+) TCACAA/GTGGAA 1 -- int134Minor allele frequency- G:0.49NS EA NA WA CSA 2965
    rs1885758351,2
    --173449226(+) AGATAC/TACTCT 1 -- int10--------
    rs1929758561,2
    --173449354(+) GAAGAC/TCTTTT 1 -- int10--------
    rs1848582851,2
    --173449365(+) TCCTTC/TTTGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRDX6 (173446405 - 173457946 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRDX6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831915CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDX6
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602316    OMIM disorders: --

    Selected diseases for PRDX6 (see all 38):    
    About MalaCards
    gnathomiasis    chancroid    fuchs' endothelial dystrophy    borna disease
    gastroduodenitis    pulmonary sarcoidosis    tauopathy    lung squamous cell carcinoma
    endocarditis    sarcoidosis    down syndrome    oligodendroglioma
    esophageal cancer    cataract    tuberculosis    endotheliitis
    malaria    influenza    atherosclerosis    astrocytoma

    1 disease from the University of Copenhagen DISEASES database for PRDX6:
    Gnathomiasis

    PRDX6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for PRDX6 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 18.6 6 18606987 (2), 20003713 (1), 19424615 (1), 11497302 (1)
    breast cancer 18.1 15 17980029 (5), 11497302 (4), 18272409 (1), 17163455 (1) (see all 6)
    neurodegenerative diseases 14.4 3 18606987 (2), 19445961 (1)
    cancer lung 13.1 4 16635084 (1), 19937138 (1), 19797004 (1), 20354123 (1)
    shock 8.42 8 11677226 (2), 19399945 (1), 16540677 (1), 16637015 (1) (see all 5)
    tumors 5.44 10 16725008 (3), 15239128 (1), 12530083 (1), 11497302 (1) (see all 7)
    necrosis 0 1 20347000 (1)
    down syndrome 0 1 11771746 (1)
    lung diseases 0 2 16635084 (1), 19737146 (1)
    adenocarcinoma 0 1 15239128 (1)

    Genetic Association Database (GAD): PRDX6
    Human Genome Epidemiology (HuGE) Navigator: PRDX6 (8 documents)

    Export disorders for PRDX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRDX6 gene, integrated from 10 sources (see all 228):
    (articles sorted by number of sources associating them with PRDX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PubMed id 10893423)1, 2, 9 Chen J.-W.... Fisher A.B. (J. Biol. Chem. 2000)
    2. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PubMed id 11233154)1, 3, 9 Phelan S.A. (amp 1999)
    3. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PubMed id 9497358)1, 2, 9 Kang S.W.... Rhee S.G. (J. Biol. Chem. 1998)
    4. Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution. (PubMed id 9587003)1, 2, 9 Choi H.-J.... Ryu S.-E. (Nat. Struct. Biol. 1998)
    5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    6. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    7. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
    8. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2 Vascotto C.... Tell G. (Mol. Cell. Biol. 2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9588 HGNC: 16753 AceView: PRDX6 Ensembl:ENSG00000117592 euGenes: HUgn9588
    ECgene: PRDX6 Kegg: 9588 H-InvDB: PRDX6

    (According to HUGE)
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    HUGE: KIAA0106

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRDX6 Pharmacogenomics, SNPs, Pathways
    NIEHS SNPshttp://egp.gs.washington.edu/data/prdx6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRDX6 gene:
    Search GeneIP for patents involving PRDX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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