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Aliases for PRDX6 Gene

Aliases for PRDX6 Gene

  • Peroxiredoxin 6 2 3 5
  • Acidic Calcium-Independent Phospholipase A2 3 4
  • Non-Selenium Glutathione Peroxidase 3 4
  • Red Blood Cells Page Spot 12 3 4
  • Antioxidant Protein 2 3 4
  • Liver 2D Page Spot 40 3 4
  • 1-Cys Peroxiredoxin 3 4
  • 24 KDa Protein 3 4
  • EC 1.11.1.15 4 61
  • 1-Cys PRX 3 4
  • AiPLA2 3 4
  • NSGPx 3 4
  • AOP2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 128m 3
  • Peroxiredoxin-6 3
  • EC 1.11.1.9 4
  • HEL-S-128m 3
  • EC 3.1.1.- 4
  • KIAA0106 4
  • 1-Cys 3
  • PRX 3
  • P29 3

External Ids for PRDX6 Gene

Previous GeneCards Identifiers for PRDX6 Gene

  • GC01P169075
  • GC01P170027
  • GC01P170685
  • GC01P170178
  • GC01P171713
  • GC01P173446
  • GC01P144671

Summaries for PRDX6 Gene

Entrez Gene Summary for PRDX6 Gene

  • The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX6 Gene

PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include Gnathomiasis and Fuchs' Endothelial Dystrophy. Among its related pathways are Innate Immune System and Cellular Senescence. GO annotations related to this gene include oxidoreductase activity and antioxidant activity.

UniProtKB/Swiss-Prot for PRDX6 Gene

  • Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Gene Wiki entry for PRDX6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX6 Gene

Genomics for PRDX6 Gene

Regulatory Elements for PRDX6 Gene

Enhancers for PRDX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G173506 1.4 Ensembl ENCODE 22.9 +30.1 30092 1.8 HDGF PKNOX1 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B GAS5 PRDX6 KLHL20 ANKRD45 RC3H1 ENSG00000238272 SUCO SLC9C2 PIR59510
GH01G173420 1.4 Ensembl ENCODE dbSUPER 21.4 -56.7 -56661 0.9 HDGF ATF1 CBX3 ARNT WRNIP1 SIN3A RAD21 CHAMP1 RFX5 RCOR1 PRDX6 CENPL DARS2 KLHL20 GC01M173428 LOC646870
GH01G173473 1.5 FANTOM5 ENCODE 14.8 -0.4 -445 7.1 CREB3L1 DMAP1 YY1 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF585B GLIS1 KLHL20 PRDX6 GAS5 CENPL DARS2 LOC100506023 LOC101928673
GH01G173428 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -46.8 -46824 3.5 PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 ZNF766 ZNF143 PRDX6 SLC9C2 GC01M173428 GC01P173448
GH01G173412 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -63.0 -62964 4.6 HDGF TBP FOXA2 ATF1 TBL1XR1 ZNF766 GATA2 EGR1 RELB ETV6 KLHL20 CENPL DARS2 PRDX6 ENSG00000224228 GC01M173428 LOC646870
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRDX6 on UCSC Golden Path with GeneCards custom track

Promoters for PRDX6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015976 234 2601 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for PRDX6 Gene

Chromosome:
1
Start:
173,477,266 bp from pter
End:
173,488,807 bp from pter
Size:
11,542 bases
Orientation:
Plus strand

Genomic View for PRDX6 Gene

Genes around PRDX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX6 Gene

Proteins for PRDX6 Gene

  • Protein details for PRDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30041-PRDX6_HUMAN
    Recommended name:
    Peroxiredoxin-6
    Protein Accession:
    P30041
    Secondary Accessions:
    • A8JZY7
    • P32077
    • Q5TAH4
    • Q5ZEZ8

    Protein attributes for PRDX6 Gene

    Size:
    224 amino acids
    Molecular mass:
    25035 Da
    Quaternary structure:
    • Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B.
    Miscellaneous:
    • Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress.
    • The active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6 conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly reduced to cysteine by glutathione and not thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX6 Gene

neXtProt entry for PRDX6 Gene

Selected DME Specific Peptides for PRDX6 Gene

P30041:
  • VATPVDWK
  • DFTPVCTTEL
  • TTGRNFDE

Post-translational modifications for PRDX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRDX6 (Peroxiredoxin 6)
  • Cell Signaling Technology (CST) Antibodies for PRDX6 (PRDX6)
  • Cloud-Clone Corp. Antibodies for PRDX6

Domains & Families for PRDX6 Gene

Gene Families for PRDX6 Gene

Suggested Antigen Peptide Sequences for PRDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30041

UniProtKB/Swiss-Prot:

PRDX6_HUMAN :
  • Belongs to the AhpC/TSA family. Rehydrin subfamily.
Family:
  • Belongs to the AhpC/TSA family. Rehydrin subfamily.
genes like me logo Genes that share domains with PRDX6: view

Function for PRDX6 Gene

Molecular function for PRDX6 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Enzyme Numbers (IUBMB) for PRDX6 Gene

Gene Ontology (GO) - Molecular Function for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004601 peroxidase activity IEA --
GO:0004602 glutathione peroxidase activity IMP,IEA 10893423
GO:0005515 protein binding IPI 19188445
GO:0016209 antioxidant activity IEA --
genes like me logo Genes that share ontologies with PRDX6: view
genes like me logo Genes that share phenotypes with PRDX6: view

Animal Models for PRDX6 Gene

MGI Knock Outs for PRDX6:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX6

CRISPR Products

miRNA for PRDX6 Gene

miRTarBase miRNAs that target PRDX6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX6 Gene

Localization for PRDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX6 Gene

Cytoplasm. Lysosome. Cytoplasmic vesicle. Note=Also found in lung secretory organelles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX6 gene
Compartment Confidence
extracellular 5
cytosol 5
lysosome 5
plasma membrane 3
mitochondrion 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23580065
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA,IEA 19188445
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with PRDX6: view

Pathways & Interactions for PRDX6 Gene

genes like me logo Genes that share pathways with PRDX6: view

Pathways by source for PRDX6 Gene

1 Cell Signaling Technology pathway for PRDX6 Gene
1 BioSystems pathway for PRDX6 Gene
1 KEGG pathway for PRDX6 Gene
1 GeneGo (Thomson Reuters) pathway for PRDX6 Gene

SIGNOR curated interactions for PRDX6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006979 response to oxidative stress IMP 10893423
GO:0008152 metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0034599 cellular response to oxidative stress TAS --
genes like me logo Genes that share ontologies with PRDX6: view

Drugs & Compounds for PRDX6 Gene

(17) Drugs for PRDX6 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma Target 0
Oxygen Approved, Vet_approved Pharma 0
Carbon dioxide Approved, Vet_approved Pharma 0
Formaldehyde Approved, Vet_approved Pharma 93
Water Approved Pharma 0

(21) Additional Compounds for PRDX6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Phenylacetamide
  • (alpha-)2-Phenylacetamide
  • 2-Phenyl-Acetamide
  • alpha-Phenylacetamide
  • alpha-Toluamide
  • alpha-Toluimidic acid
103-81-1
5-Hydroxyconiferyl alcohol
Coniferyl alcohol
  • (E) 3-(4-hydroxy-3-methoxyphenyl)-2-Propen-1-ol
  • 3-(4-Hydroxy-3-methoxyphenyl)-2-Propen-1-ol
  • 3-(4-Hydroxy-3-methoxyphenyl)allyl alcohol
  • 4-((1E)-3-Hydroxy-1-propenyl)-2-methoxyphenol
  • 4-(3-Hydroxy-1-propenyl)-2-methoxy-Phenol
458-35-5
Hypothiocyanite
  • Cyanosulfoxylate
  • Hypothiocyanite
  • N,6-Didehydro-3,6-dihydro-3-methyl-Adenosine
  • OSCN-Hypothiocyanite ion
63296-34-4
methanol
  • Alcool methylique
  • Alcool metilico
  • Carbinol
  • CH3OH
  • Colonial spirit
67-56-1
genes like me logo Genes that share compounds with PRDX6: view

Transcripts for PRDX6 Gene

mRNA/cDNA for PRDX6 Gene

Unigene Clusters for PRDX6 Gene

Peroxiredoxin 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX6 Gene

No ASD Table

Relevant External Links for PRDX6 Gene

GeneLoc Exon Structure for
PRDX6
ECgene alternative splicing isoforms for
PRDX6

Expression for PRDX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX6 Gene

mRNA differential expression in normal tissues according to GTEx for PRDX6 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX6 Gene



Protein tissue co-expression partners for PRDX6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX6 Gene:

PRDX6

SOURCE GeneReport for Unigene cluster for PRDX6 Gene:

Hs.120

Evidence on tissue expression from TISSUES for PRDX6 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.5)
  • Bone marrow(4.4)
  • Lung(4.4)
  • Eye(3.9)
  • Skin(3.9)
  • Kidney(3.5)
  • Intestine(3.4)
  • Muscle(2.9)
  • Heart(2.8)
  • Stomach(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with PRDX6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX6 Gene

Orthologs for PRDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
-- 35
  • 100 (a)
OneToMany
PRDX6 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia PRDX6 34 35
  • 92.86 (n)
dog
(Canis familiaris)
Mammalia PRDX6 34 35
  • 91.52 (n)
rat
(Rattus norvegicus)
Mammalia Prdx6 34
  • 88.84 (n)
mouse
(Mus musculus)
Mammalia Prdx6 34 16 35
  • 87.35 (n)
Prdx6b 35
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX6 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDX6 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDX6 34 35
  • 77.98 (n)
lizard
(Anolis carolinensis)
Reptilia PRDX6 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx6 34
  • 71.04 (n)
MGC76137 34
zebrafish
(Danio rerio)
Actinopterygii prdx6 34 35
  • 67.27 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta TPX5 34
  • 59.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta Prx6005 34 35
  • 58.87 (n)
Prx2540-1 35
  • 53 (a)
OneToMany
Prx2540-2 35
  • 53 (a)
OneToMany
CG12896 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prdx-6 34 35
  • 55.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR368W 34
  • 55.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRX1 34 35 37
  • 54.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20285g 34
  • 54.65 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PER1 34
  • 55.77 (n)
rice
(Oryza sativa)
Liliopsida Os07g0638400 34
  • 56.53 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06031 34
  • 58.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10477 35
  • 55 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4007 34
Species where no ortholog for PRDX6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX6 Gene

ENSEMBL:
Gene Tree for PRDX6 (if available)
TreeFam:
Gene Tree for PRDX6 (if available)

Paralogs for PRDX6 Gene

(1) SIMAP similar genes for PRDX6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PRDX6 Gene

genes like me logo Genes that share paralogs with PRDX6: view

No data available for Paralogs for PRDX6 Gene

Variants for PRDX6 Gene

Sequence variations from dbSNP and Humsavar for PRDX6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000196271 -- 173,482,322(+) TTTCA(C/T)GTTCA intron-variant
rs1000227542 -- 173,481,971(+) CCTAC(C/G)TAGCA intron-variant
rs1000324588 -- 173,476,577(+) TTCAT(-/AACA)AACAG intron-variant, upstream-variant-2KB
rs1000541494 -- 173,488,966(+) TGATG(C/T)CACCA downstream-variant-500B
rs1000544094 -- 173,488,584(+) TCCCA(A/G)GGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRDX6 Gene

Variant ID Type Subtype PubMed ID
nsv831915 CNV gain+loss 17160897

Variation tolerance for PRDX6 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX6 Gene

Disorders for PRDX6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRDX6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gnathomiasis
  • gnathostomiasis
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search PRDX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX6

Genetic Association Database (GAD)
PRDX6
Human Genome Epidemiology (HuGE) Navigator
PRDX6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX6
genes like me logo Genes that share disorders with PRDX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX6 Gene

Publications for PRDX6 Gene

  1. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PMID: 10893423) Chen J.-W. … Fisher A.B. (J. Biol. Chem. 2000) 3 4 22 64
  2. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PMID: 11233154) Phelan S.A. (Antioxid. Redox Signal. 1999) 2 3 22 64
  3. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PMID: 9497358) Kang S.W. … Rhee S.G. (J. Biol. Chem. 1998) 3 4 22 64
  4. Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution. (PMID: 9587003) Choi H.-J. … Ryu S.-E. (Nat. Struct. Biol. 1998) 3 4 22 64
  5. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PMID: 20485444) Wang Y. … Huang W. (J. Hum. Genet. 2010) 3 46 64

Products for PRDX6 Gene

Sources for PRDX6 Gene

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