PRDX6 Gene

Aliases
for PRDX6 gene

Previous GC identifers: GC01P169075 GC01P170027 GC01P170685 GC01P170178 GC01P171713 GC01P144671

Summaries
for PRDX6 gene

Genomic Views
for PRDX6 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004487.19  

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRDX6 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX6

PRDX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P173446:  view genomic region     (about GC identifiers)

Proteins
for PRDX6 gene

1 PDB 3D structure from and Proteopedia for PRDX6:

1PRX (3D)    

Explore the universe of human proteins at neXtProt for PRDX6: NX_P30041

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PRDX6 OriGene Protein Over-expression Lysate: PRDX6 OriGene Custom Protein Services for PRDX6
	GenScript Custom Purified and Recombinant Proteins Services for PRDX6
	Novus Biologicals PRDX6 Proteins Novus Biologicals PRDX6 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PRDX6
	Uscn Proteins for PRDX6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX6
	R&D Systems Antibodies for PRDX6 (Peroxiredoxin 6)
	OriGene Antibodies (see all 2): PRDX6 OriGene Custom Antibody Services for PRDX6
	GenScript Superior Antibodies for PRDX6
	Novus Biologicals PRDX6 Antibodies
	Abcam antibodies for PRDX6
	Uscn Antibodies for PRDX6
	ThermoFisher Antibody for PRDX6

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PRDX6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PRDX6

Protein Domains /
Families
for PRDX6 gene

ProtoNet protein and cluster: P30041

Function
for PRDX6 gene

Enzyme Numbers (IUBMB): EC 1.11.1.15^{1 2} EC 1.11.1.9¹ EC 3.1.1.-¹

miRNA Products:		miRTarBase miRNAs that target PRDX6: hsa-mir-632 (MIRT004940)
		OriGene 3'-UTR Clone: PRDX6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX6
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDX6 (see all 9):
		hsa-miR-3678-3p hsa-miR-579 hsa-miR-124 hsa-miR-149 hsa-miR-186 hsa-miR-506 hsa-miR-24 hsa-miR-3133
		SwitchGear 3'UTR luciferase reporter plasmid: PRDX6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRDX6 (see all 10) OriGene shRNA RFP: PRDX6 OriGene siRNA: PRDX6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRDX6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PRDX6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX6 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PRDX6 (NM_004905)
		Sino Biological Human cDNA Clone for PRDX6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRDX6
		Search LifeMap BioReagents cell lines for PRDX6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX6

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Prdx6)

Pathways & Interactions
for PRDX6 gene

	Super-pathway	contained gene-specific pathways
1	Immune response CD16 signaling in NK cells	Immune response CD16 signaling in NK cells 1.00 Immune response_CD16 signaling in NK cells 0.99
2	Metabolism	Metabolic pathways 0.38
3	Tyrosine metabolism	Phenylalanine metabolism 0.35

1 EMD Millipore Pathway for PRDX6

Immune response CD16 signaling in NK cells

1 GeneGo (Thomson Reuters) Pathway for PRDX6

Immune response CD16 signaling in NK cells

2         Kegg Pathways  (Kegg details for PRDX6)

	Phenylalanine metabolism
	Metabolic pathways

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for PRDX6 gene

Transcripts
for PRDX6 gene

Expression
for PRDX6 gene

PRDX6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGAGAAG

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Spinal CordSpinal Floor PlateFloor Plate Cells			Neural Ectoderm
	BrainMedulla Oblongata			Brain
	Neural TubeMetencephalon			Neural Tube
	Spinal CordSpinal Floor Plate			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRDX6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRDX6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRDX6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDX6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX6

Orthologs
for PRDX6 gene

Paralogs
for PRDX6 gene

Paralogs for PRDX6 gene

1 SIMAP similar gene for PRDX6 using alignment to 1 protein entry:     PRDX6_HUMAN:

PRDX1

PRDX6 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for PRDX6
PGOHUM00000239899 PGOHUM00000246159

Genomic Variants
for PRDX6 gene

10/273 NCBI SNPs in PRDX6 are shown (see all 273)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs94257221,2	C,F,H,	--	173444645(+)	GGCACC/TGTAAA	2	--	int1 us2k1		23		NS EA NA WA CSA	944
rs351527011,2	C,	--	173444646(+)	GCACTG/ATAAAT	2	--	us2k1 int1		6		NS NA	306
rs127391421,2	C,F,	--	173444655(+)	ATTCTA/GATGAG	2	--	us2k1 int1		8		NA NS	310
rs352802741,2	F	--	173444677(+)	ATTTGC/TTTAAT	2	--	int1 us2k1		5		NS	186
rs1398397181,2		--	173444727(+)	TCAATA/CATCTG	2	--	int1 us2k1		0	--	--	--	--
rs357533241,2	C,F,	--	173444737(+)	GTTTCT/AGTATT	2	--	us2k1 int1		6		NS NA	306
rs1848995131,2		--	173444780(+)	TAGCTA/GATTTC	2	--	int1 us2k1		0	--	--	--	--
rs43545721,2	C,F,A,H,	--	173444836(+)	CCCAAT/CTATTC	2	--	us2k1 int1		27		NS EA NA WA CSA	1923
rs1881018921,2		--	173444957(+)	TTACCA/GGTAAT	2	--	us2k1 int1		0	--	--	--	--
rs1810069501,2		--	173444964(+)	TAATCC/TTACTG	2	--	us2k1 int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PRDX6 (173446405 - 173457946 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRDX6
     1 CNV: 4262

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRDX6

DNA2.0 Custom Variant and Variant Library Synthesis for PRDX6

Disorders / Diseases
for PRDX6 gene

20/41 diseases for PRDX6

10/12 Novoseek disease relationships for PRDX6 gene (see all 12)    About this table

Publications
for PRDX6 gene

PubMed articles for PRDX6 gene, integrated from 9 sources (see all 215): (articles sorted by number of sources associating them with PRDX6)

Utopia: connect your pdf to the dynamic world of online information

1. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PubMed id 10893423)^{1, 2, 9} Chen J.-W.... Fisher A.B. (2000)
2. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PubMed id 11233154)^{1, 3, 9} Phelan S.A. (1999)
3. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PubMed id 9497358)^{1, 2, 9} Kang S.W.... Rhee S.G. (1998)
4. Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution. (PubMed id 9587003)^{1, 2, 9} Choi H.-J.... Ryu S.-E. (1998)
5. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)^{1, 2} Vascotto C....Tell G. (2009)
6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
7. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
8. Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6. (PubMed id 16186110)^{1, 2} Gao L....Andreadis A. (2005)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)

External Searches for PRDX6 gene

Genome Databases showing PRDX6 gene

Other Databases showing PRDX6 gene

Specialized Databases showing PRDX6 gene

Products
for PRDX6 gene