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Aliases for PRDX6 Gene

Aliases for PRDX6 Gene

  • Peroxiredoxin 6 2 3
  • Acidic Calcium-Independent Phospholipase A2 3 4
  • Non-Selenium Glutathione Peroxidase 3 4
  • Red Blood Cells Page Spot 12 3 4
  • Antioxidant Protein 2 3 4
  • Liver 2D Page Spot 40 3 4
  • 1-Cys Peroxiredoxin 3 4
  • 24 KDa Protein 3 4
  • EC 1.11.1.15 4 63
  • 1-Cys PRX 3 4
  • AiPLA2 3 4
  • NSGPx 3 4
  • AOP2 3 4
  • Epididymis Secretory Sperm Binding Protein Li 128m 3
  • Peroxiredoxin-6 3
  • EC 1.11.1.9 4
  • HEL-S-128m 3
  • EC 3.1.1.- 4
  • KIAA0106 4
  • 1-Cys 3
  • P29 3
  • PRX 3

External Ids for PRDX6 Gene

Previous GeneCards Identifiers for PRDX6 Gene

  • GC01P169075
  • GC01P170027
  • GC01P170685
  • GC01P170178
  • GC01P171713
  • GC01P173446
  • GC01P144671

Summaries for PRDX6 Gene

Entrez Gene Summary for PRDX6 Gene

  • The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX6 Gene

PRDX6 (Peroxiredoxin 6) is a Protein Coding gene. Diseases associated with PRDX6 include gnathomiasis and fuchs' endothelial dystrophy. Among its related pathways are Metabolism and Cellular Senescence. GO annotations related to this gene include glutathione peroxidase activity and antioxidant activity.

UniProtKB/Swiss-Prot for PRDX6 Gene

  • Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury

Gene Wiki entry for PRDX6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX6 Gene

Genomics for PRDX6 Gene

Regulatory Elements for PRDX6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRDX6 Gene

Start:
173,477,266 bp from pter
End:
173,488,807 bp from pter
Size:
11,542 bases
Orientation:
Plus strand

Genomic View for PRDX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX6 Gene

Proteins for PRDX6 Gene

  • Protein details for PRDX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30041-PRDX6_HUMAN
    Recommended name:
    Peroxiredoxin-6
    Protein Accession:
    P30041
    Secondary Accessions:
    • A8JZY7
    • P32077
    • Q5TAH4
    • Q5ZEZ8

    Protein attributes for PRDX6 Gene

    Size:
    224 amino acids
    Molecular mass:
    25035 Da
    Quaternary structure:
    • Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B.
    Miscellaneous:
    • Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress
    • The active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6 conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly reduced to cysteine by glutathione and not thioredoxin

    Three dimensional structures from OCA and Proteopedia for PRDX6 Gene

neXtProt entry for PRDX6 Gene

Proteomics data for PRDX6 Gene at MOPED

Selected DME Specific Peptides for PRDX6 Gene

Post-translational modifications for PRDX6 Gene

  • Ubiquitination at Lys209
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRDX6 (Peroxiredoxin 6)

Domains for PRDX6 Gene

Suggested Antigen Peptide Sequences for PRDX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30041

UniProtKB/Swiss-Prot:

PRDX6_HUMAN :
  • P30041
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the AhpC/TSA family. Rehydrin subfamily.
genes like me logo Genes that share domains with PRDX6: view

No data available for Gene Families for PRDX6 Gene

Function for PRDX6 Gene

Molecular function for PRDX6 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH
UniProtKB/Swiss-Prot CatalyticActivity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
UniProtKB/Swiss-Prot Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury

Enzyme Numbers (IUBMB) for PRDX6 Gene

Gene Ontology (GO) - Molecular Function for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004602 glutathione peroxidase activity IEA --
GO:0004623 phospholipase A2 activity IDA 10893423
GO:0005515 protein binding IPI 19188445
GO:0016209 antioxidant activity NAS 10893423
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with PRDX6: view
genes like me logo Genes that share phenotypes with PRDX6: view

Animal Models for PRDX6 Gene

MGI Knock Outs for PRDX6:

Animal Model Products

CRISPR Products

miRNA for PRDX6 Gene

miRTarBase miRNAs that target PRDX6

No data available for Transcription Factor Targeting and HOMER Transcription for PRDX6 Gene

Localization for PRDX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX6 Gene

Cytoplasm. Lysosome. Cytoplasmic vesicle. Note=Also found in lung secretory organelles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX6 Gene COMPARTMENTS Subcellular localization image for PRDX6 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 3
cytoskeleton 2
lysosome 2
mitochondrion 2
vacuole 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005737 cytoplasm IDA 19188445
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PRDX6: view

Pathways for PRDX6 Gene

genes like me logo Genes that share pathways with PRDX6: view

Pathways by source for PRDX6 Gene

1 GeneGo (Thomson Reuters) pathway for PRDX6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PRDX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006979 response to oxidative stress IDA 10893423
GO:0009395 phospholipid catabolic process IDA 10893423
GO:0042744 hydrogen peroxide catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PRDX6: view

Compounds for PRDX6 Gene

(10) HMDB Compounds for PRDX6 Gene

Compound Synonyms Cas Number PubMed IDs
2-Phenylacetamide
  • Benzeneacetamide
103-81-1
4-Coumaryl alcohol
  • 3-(4-Hydroxyphenyl)-1-propane
1076-38-6
Cyanosulfurous acid anion
  • CNSu
Not Available
Formaldehyde
  • Aldeide formica
50-00-0
Heme
  • (protoporphyrinato)iron
14875-96-8

(1) Drugbank Compounds for PRDX6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(N-Morpholino)-Ethanesulfonic Acid
target

(22) Novoseek inferred chemical compound relationships for PRDX6 Gene

Compound -log(P) Hits PubMed IDs
cysteine sulfinic acid 88.2 6
sulfinic acid 84.5 3
mj 33 76.6 2
mercaptosuccinic acid 70 2
cysteine 65.4 28
genes like me logo Genes that share compounds with PRDX6: view

Transcripts for PRDX6 Gene

mRNA/cDNA for PRDX6 Gene

Unigene Clusters for PRDX6 Gene

Peroxiredoxin 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDX6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX6 Gene

No ASD Table

Relevant External Links for PRDX6 Gene

GeneLoc Exon Structure for
PRDX6
ECgene alternative splicing isoforms for
PRDX6

Expression for PRDX6 Gene

mRNA expression in normal human tissues for PRDX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRDX6 Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX6 Gene

SOURCE GeneReport for Unigene cluster for PRDX6 Gene Hs.120

genes like me logo Genes that share expressions with PRDX6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRDX6 Gene

Orthologs for PRDX6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
PRDX6 35
  • 99.7 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PRDX6 35
  • 92.86 (n)
  • 95.09 (a)
PRDX6 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX6 35
  • 91.52 (n)
  • 92.86 (a)
PRDX6 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdx6 35
  • 87.35 (n)
  • 89.73 (a)
Prdx6 16
Prdx6 36
  • 90 (a)
OneToMany
Prdx6b 36
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PRDX6 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX6 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx6 35
  • 88.84 (n)
  • 91.52 (a)
chicken
(Gallus gallus)
Aves PRDX6 35
  • 77.98 (n)
  • 86.43 (a)
PRDX6 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX6 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76137 35
prdx6 35
  • 71.04 (n)
  • 76.92 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
prdx6 35
  • 67.27 (n)
  • 73.64 (a)
prdx6 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TPX5 35
  • 59.73 (n)
  • 60.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12896 36
  • 52 (a)
OneToMany
Prx2540-1 36
  • 53 (a)
OneToMany
Prx2540-2 36
  • 53 (a)
OneToMany
Prx6005 35
  • 58.87 (n)
  • 61.01 (a)
Prx6005 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea prdx-6 35
  • 55.56 (n)
  • 52.38 (a)
prdx-6 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR368W 35
  • 55.45 (n)
  • 50.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRX1 35
  • 54.81 (n)
  • 50.96 (a)
PRX1 36
  • 41 (a)
OneToOne
PRX1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20285g 35
  • 54.65 (n)
  • 48.56 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PER1 35
  • 55.77 (n)
  • 52.61 (a)
rice
(Oryza sativa)
Liliopsida Os07g0638400 35
  • 56.53 (n)
  • 53.92 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06031 35
  • 58.73 (n)
  • 53.33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4007 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10477 36
  • 55 (a)
OneToOne
Species with no ortholog for PRDX6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX6 Gene

ENSEMBL:
Gene Tree for PRDX6 (if available)
TreeFam:
Gene Tree for PRDX6 (if available)

Paralogs for PRDX6 Gene

Selected SIMAP similar genes for PRDX6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PRDX6 Gene

genes like me logo Genes that share paralogs with PRDX6: view

No data available for Paralogs for PRDX6 Gene

Variants for PRDX6 Gene

Sequence variations from dbSNP and Humsavar for PRDX6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2000 -- 173,488,695(+) GTGAA(A/G)AGAAG utr-variant-3-prime
rs4611 -- 173,487,878(+) AGAAG(C/T)TGGTG utr-variant-3-prime
rs7314 -- 173,488,460(-) AGGTA(C/T)AGAAT utr-variant-3-prime
rs15268 -- 173,487,933(+) CAATT(A/C)CATAA utr-variant-3-prime
rs15269 -- 173,488,738(+) TCTTC(A/T)TGCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRDX6 Gene

Variant ID Type Subtype PubMed ID
nsv831915 CNV Gain+Loss 17160897

Relevant External Links for PRDX6 Gene

HapMap Linkage Disequilibrium report
PRDX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX6 Gene

Disorders for PRDX6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PRDX6 Gene including...

Search for PRDX6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PRDX6 Gene

(12) Novoseek inferred disease relationships for PRDX6 Gene

Disease -log(P) Hits PubMed IDs
cancer 18.6 5
breast cancer 18.1 13
neurodegenerative diseases 14.4 3
cancer lung 13.1 4
shock 8.42 6

Relevant External Links for PRDX6

Genetic Association Database (GAD)
PRDX6
Human Genome Epidemiology (HuGE) Navigator
PRDX6
genes like me logo Genes that share disorders with PRDX6: view

No data available for UniProtKB/Swiss-Prot for PRDX6 Gene

Publications for PRDX6 Gene

  1. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PMID: 9497358) Kang S.W. … Rhee S.G. (J. Biol. Chem. 1998) 3 4 23
  2. Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution. (PMID: 9587003) Choi H.-J. … Ryu S.-E. (Nat. Struct. Biol. 1998) 3 4 23
  3. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PMID: 10893423) Chen J.-W. … Fisher A.B. (J. Biol. Chem. 2000) 3 4 23
  4. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PMID: 11233154) Phelan S.A. (Antioxid. Redox Signal. 1999) 2 3 23
  5. Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. (PMID: 11677226) Fatma N. … Chylack L.T. (J. Biol. Chem. 2001) 3 23

Products for PRDX6 Gene

Sources for PRDX6 Gene

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