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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRDX6 Gene

protein-coding   GIFtS: 70
GCID: GC01P173446

Peroxiredoxin 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peroxiredoxin 61 2     NSGPx2 3
Acidic Calcium-Independent Phospholipase A22 3     aiPLA22 3
Antioxidant Protein 22 3     EC 1.11.1.153 8
Liver 2D Page Spot 402 3     1-Cys2
Non-Selenium Glutathione Peroxidase2 3     PRX2
Red Blood Cells Page Spot 122 3     p292
1-Cys Peroxiredoxin2 3     peroxiredoxin-62
1-Cys PRX2 3     EC 1.11.1.93
24 KDa Protein2 3     EC 3.1.1.-3
AOP22 3     KIAA01063

External Ids:    HGNC: 167531   Entrez Gene: 95882   Ensembl: ENSG000001175927   OMIM: 6023165   UniProtKB: P300413   

Export aliases for PRDX6 gene to outside databases

Previous GC identifers: GC01P169075 GC01P170027 GC01P170685 GC01P170178 GC01P171713 GC01P144671


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDX6 Gene:
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a
bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce
H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the
regulation of phospholipid turnover as well as in protection against oxidative injury. (provided by RefSeq, Jul
2008)

GeneCards Summary for PRDX6 Gene: 
PRDX6 (peroxiredoxin 6) is a protein-coding gene. Diseases associated with PRDX6 include gnathomiasis, and chancroid, and among its related super-pathways are Metabolism and Tyrosine metabolism. GO annotations related to this gene include glutathione peroxidase activity and antioxidant activity.

UniProtKB/Swiss-Prot: PRDX6_HUMAN, P30041
Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and
phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection
against oxidative injury

Gene Wiki entry for PRDX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDX6 gene promoter:
         MEF-2A   C/EBPbeta   STAT1   AML1a   MEF-2   Pax-2   aMEF-2   Pax-2a   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRDX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRDX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q24.1

PRDX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P173446:  view genomic region     (about GC identifiers)

Start:
173,446,405 bp from pter      End:
173,457,946 bp from pter
Size:
11,542 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRDX6_HUMAN, P30041 (See protein sequence)
Recommended Name: Peroxiredoxin-6  
Size: 224 amino acids; 25035 Da
Subunit: Homotetramer. Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration. May interact with
HTR2A (By similarity). Interacts with APEX1 and STH. May interact with FAM168B
Subcellular location: Cytoplasm. Lysosome (By similarity). Cytoplasmic vesicle (By similarity). Note=Also found in
lung secretory organelles (By similarity)
Miscellaneous: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Unlike 2-Cys peroxiredoxins, PRDX6
conserves only this peroxidatic cysteine. To regenerate and activate the enzyme, the oxidized form is directly
reduced to cysteine by glutathione and not thioredoxin
Miscellaneous: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress
1 PDB 3D structure from and Proteopedia for PRDX6:
1PRX (3D)    
Secondary accessions: A8JZY7 P32077 Q5TAH4 Q5ZEZ8

Explore the universe of human proteins at neXtProt for PRDX6: NX_P30041

Explore proteomics data for PRDX6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30041

  • 3 DME Specific Peptides for PRDX6 (P30041)
     VATPVDWK  TTGRNFDE  DFTPVCTTEL 

    PRDX6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRDX6 Protein Expression
    REFSEQ proteins: NP_004896.1  
    ENSEMBL proteins: 
     ENSP00000342026  

    Human Recombinant Protein Products for PRDX6: 
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    Novus Biologicals PRDX6 Proteins
    Novus Biologicals PRDX6 Lysate
    Sino Biological Recombinant Protein for PRDX6
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PRDX6
    Cloud-Clone Corp. Proteins for PRDX6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19188445
    GO:0005764lysosome IEA--
    GO:0005829cytosol NAS9497358
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    PRDX6 for ontologies           About GeneDecksing



    PRDX6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX6
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry P30041

    ProtoNet protein and cluster: P30041

    1 Blocks protein domain: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX6_HUMAN, P30041
    Similarity: Belongs to the AhpC/TSA family. Rehydrin subfamily
    Similarity: Contains 1 thioredoxin domain


    PRDX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX6_HUMAN, P30041
    Function: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and
    phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection
    against oxidative injury
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
    Catalytic activity: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

         Enzyme Numbers (IUBMB): EC 1.11.1.151 2 EC 1.11.1.91 EC 3.1.1.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004602glutathione peroxidase activity IEA--
    GO:0004623phospholipase A2 activity IDA10893423
    GO:0005515protein binding IPI19188445
    GO:0016209antioxidant activity NAS10893423
    GO:0016491oxidoreductase activity ----
         
    PRDX6 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRDX6:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prdx6):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  liver/biliary system 
     normal  other  renal/urinary system  respiratory system  vision/eye 

    PRDX6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prdx6tm1Abf for PRDX6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRDX6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRDX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX6 

    miRNA
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    miRTarBase miRNAs that target PRDX6:
    hsa-mir-632 (MIRT004940)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX6
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDX6 (see all 9):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-124 hsa-miR-149 hsa-miR-186 hsa-miR-506 hsa-miR-24 hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidPRDX6 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRDX6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    3Immune response Fc epsilon RI pathway
    Immune response CD16 signaling in NK cells0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PRDX6
        Immune response CD16 signaling in NK cells


    1 GeneGo (Thomson Reuters) Pathway for PRDX6
        Immune response CD16 signaling in NK cells



    2         Kegg Pathways  (Kegg details for PRDX6):
        Phenylalanine metabolism
    Metabolic pathways


    PRDX6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/99 Interacting proteins for PRDX6 (P300412, 3 ENSP000003420264) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120042, 3MINT-7995228 I2D: score=2 
    NCF2P198783, ENSP000003565054I2D: score=3 STRING: ENSP00000356505
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    GPX4P369693, ENSP000003461034I2D: score=1 STRING: ENSP00000346103
    SUMO4Q6EEV63, ENSP000003186354I2D: score=1 STRING: ENSP00000318635
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress IDA10893423
    GO:0009395phospholipid catabolic process IDA10893423
    GO:0042744hydrogen peroxide catabolic process IEA--
    GO:0055114oxidation-reduction process ----

    PRDX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRDX6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDX6

    10 HMDB Compounds for PRDX6    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-PhenylacetamideBenzeneacetamide (see all 10)103-81-1--
    4-Coumaryl alcohol3-(4-Hydroxyphenyl)-1-propane (see all 12)1076-38-6--
    Cyanosulfurous acid anionCNSu;cyanosulfurous acid ----
    FormaldehydeAldeide formica (see all 16)50-00-0--
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    HypothiocyaniteCyanosulfoxylate;Hypothiocyanite;OSCN-Hypothiocyanite ion;N,6-didehydro-3,6-dihydro-3-methyl-Adenosine 63296-34-4--
    L-Phenylalanine(-)-beta-Phenylalanine (see all 28)63-91-2--
    MethanolAlcool methylique (see all 23)67-56-1--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for PRDX6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--10592235

    10/22 Novoseek inferred chemical compound relationships for PRDX6 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine sulfinic acid 88.2 6 17176052 (3), 17653208 (1), 15952770 (1), 19176523 (1)
    sulfinic acid 84.5 4 19812042 (1), 18593714 (1), 15917647 (1)
    mj 33 76.6 10 9787801 (1), 10893423 (1)
    mercaptosuccinic acid 70 3 12144348 (1), 10893423 (1)
    cysteine 65.4 40 11832487 (3), 9497358 (2), 16916801 (2), 18084891 (2) (see all 23)
    h2o2 64.5 14 9497358 (2), 11771746 (1), 16401067 (1), 20138108 (1) (see all 12)
    glyceraldehyde 3-phosphate 46.7 15 19737146 (6), 18647502 (1), 15590625 (1), 16707281 (1) (see all 6)
    oxygen 42.7 15 16539693 (1), 17026836 (1), 18386021 (1), 18184874 (1) (see all 9)
    nadph 36.4 6 19345687 (2), 19825629 (1)
    phospholipid 34.2 10 17652308 (3), 12151315 (1), 9787801 (1), 12193653 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about PRDX6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRDX6 gene: 
    NM_004905.2  

    Unigene Clusters for PRDX6:

    Peroxiredoxin 6
    Hs.120  [show with all ESTs], Hs.731505  [show with all ESTs]
    Unigene Representative Sequences: NM_004905, BX455317
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340385(uc001giy.1) ENST00000460950 ENST00000470017

    miRNA
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    Additional mRNA sequence: AJ844622.2 

    24/40 DOTS entries (see all 40):

    DT.92044153  DT.100864306  DT.453489  DT.91894522  DT.100862984  DT.100862986  DT.100862959  DT.100862957 
    DT.100862964  DT.121364953  DT.102835811  DT.102835812  DT.100862979  DT.100862983  DT.91916530  DT.92033628 
    DT.100862967  DT.121364926  DT.70101606  DT.121364916  DT.100805379  DT.100862965  DT.100862975  DT.121267617 

    24/1202 AceView cDNA sequences (see all 1202):

    BQ431763 N99982 CR591733 CR606922 AU143650 CA416173 AI613248 BP355673 
    CB158331 BP342370 AI948443 BM824423 BQ219920 BI834204 AA341202 AA455149 
    BQ709655 BM792567 BG779586 BU164585 AI986148 AL536494 AA947983 BM970207 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRDX6 expression in normal human tissues (normalized intensities)      PRDX6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGAGAAG
    PRDX6 Expression
    About this image


    PRDX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Floor Plate Cells Spinal Floor Plate
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Bone (Muscoskeletal System)
             BONE MARROW   
     
     Blood (Muscoskeletal System)
             BONE MARROW   

    See PRDX6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRDX6

    SOURCE GeneReport for Unigene clusters: Hs.120 Hs.731505
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRDX6: 
              Amino Acid Metabolism II in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRDX6 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx61 , 5 peroxiredoxin 61, 5 87.35(n)1
    89.73(a)1
      1 (69.75 cM)5
    117581  NM_007453.31  NP_031479.11 
     1612401125 
    chicken
    (Gallus gallus)
    Aves PRDX61 peroxiredoxin 6 77.98(n)
    86.43(a)
      429062  NM_001039329.1  NP_001034418.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX66
    Uncharacterized protein
    81(a)
    1 ↔ 1
    4(71284129-71304057)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054278.12   -- 80.51(n)    BC054278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059671.12   -- 78.69(n)   393778  BC059671.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Prx60051 Peroxiredoxin 6005 58.83(n)
    61.29(a)
      33493  NM_078739.3  NP_523463.2 
    worm
    (Caenorhabditis elegans)
    Secernentea prdx-61 Protein PRDX-6 55.71(n)
    52.38(a)
      176837  NM_171241.2  NP_741287.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRX1(YBL064C)4
    PRX11
    Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin more4
    Prx1p1
    54.81(n)1
    50.96(a)1
      2(101156-100371)4
    8522151, 4  NP_009489.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PER11 1-Cys peroxiredoxin PER1 55.98(n)
    52.15(a)
      841231  NM_103709.3  NP_175247.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06384001 hypothetical protein 56.12(n)
    53.49(a)
      4344046  NM_001066943.1  NP_001060408.1 


    ENSEMBL Gene Tree for PRDX6 (if available)
    TreeFam Gene Tree for PRDX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRDX6 gene
    1 SIMAP similar gene for PRDX6 using alignment to 1 protein entry:     PRDX6_HUMAN:
    PRDX1

    PRDX6 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRDX6
    PGOHUM00000239899 PGOHUM00000246159


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/250 SNPs in PRDX6 are shown (see all 250)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs94257231,2
    C,F,A,H--173448495(+) TTTATG/AACACA 1 -- int116Minor allele frequency- A:0.47NS NA WA CSA EA 565
    rs94257241,2
    C,F,A,H--173448500(+) AACACA/GTGGAT 1 -- int116Minor allele frequency- G:0.50NS NA WA CSA EA 563
    rs1833193221,2
    --173448593(+) GAAAAA/CATTAA 1 -- int10--------
    rs1459861781,2
    --173448637(+) AAACAA/GCTAAA 1 -- int10--------
    rs3732527821,2
    C--173448897(+) CCAAGC/G/TAAGAC 1 -- int10--------
    rs1398923901,2
    --173448973(+) AGGACA/GTGAAC 1 -- int10--------
    rs75400651,2
    C,F,A,H--173449036(+) TCACAA/GTGGAA 1 -- int134Minor allele frequency- G:0.49NS EA NA WA CSA 2965
    rs1885758351,2
    --173449226(+) AGATAC/TACTCT 1 -- int10--------
    rs1929758561,2
    --173449354(+) GAAGAC/TCTTTT 1 -- int10--------
    rs1848582851,2
    --173449365(+) TCCTTC/TTTGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRDX6 (173446405 - 173457946 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRDX6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831915CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDX6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602316    OMIM disorders: --

    20/37 diseases for PRDX6 (see all 37):    About MalaCards
    gnathomiasis    chancroid    fuchs' endothelial dystrophy    borna disease
    gastroduodenitis    tauopathy    lung squamous cell carcinoma    pulmonary sarcoidosis
    endocarditis    sarcoidosis    down syndrome    endotheliitis
    oligodendroglioma    influenza    tuberculosis    cataract
    malaria    esophageal cancer    atherosclerosis    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for PRDX6:
    Gnathomiasis

    PRDX6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/12 Novoseek inferred disease relationships for PRDX6 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 18.6 6 18606987 (2), 20003713 (1), 19424615 (1), 11497302 (1)
    breast cancer 18.1 15 17980029 (5), 11497302 (4), 18272409 (1), 17163455 (1) (see all 6)
    neurodegenerative diseases 14.4 3 18606987 (2), 19445961 (1)
    cancer lung 13.1 4 16635084 (1), 19937138 (1), 19797004 (1), 20354123 (1)
    shock 8.42 8 11677226 (2), 19399945 (1), 16540677 (1), 16637015 (1) (see all 5)
    tumors 5.44 10 16725008 (3), 15239128 (1), 12530083 (1), 11497302 (1) (see all 7)
    necrosis 0 1 20347000 (1)
    down syndrome 0 1 11771746 (1)
    lung diseases 0 2 16635084 (1), 19737146 (1)
    adenocarcinoma 0 1 15239128 (1)

    Genetic Association Database (GAD): PRDX6
    Human Genome Epidemiology (HuGE) Navigator: PRDX6 (8 documents)

    Export disorders for PRDX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRDX6 gene, integrated from 9 sources (see all 227):
    (articles sorted by number of sources associating them with PRDX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. (PubMed id 10893423)1, 2, 9 Chen J.-W.... Fisher A.B. (2000)
    2. AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant. (PubMed id 11233154)1, 3, 9 Phelan S.A. (1999)
    3. Characterization of a mammalian peroxiredoxin that contains one conserved cysteine. (PubMed id 9497358)1, 2, 9 Kang S.W.... Rhee S.G. (1998)
    4. Crystal structure of a novel human peroxidase enzyme at 2.0-A resolution. (PubMed id 9587003)1, 2, 9 Choi H.-J.... Ryu S.-E. (1998)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. Common polymorphisms in ITGA2, PON1 and THBS2 are ass ociated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (2010)
    7. Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (2010)
    8. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2 Vascotto C....Tell G. (2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9588 HGNC: 16753 AceView: PRDX6 Ensembl:ENSG00000117592 euGenes: HUgn9588
    ECgene: PRDX6 Kegg: 9588 H-InvDB: PRDX6

    (According to HUGE)
    About This Section
    HUGE: KIAA0106

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRDX6 Pharmacogenomics, SNPs, Pathways
    NIEHS SNPshttp://egp.gs.washington.edu/data/prdx6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRDX6 gene:
    Search GeneIP for patents involving PRDX6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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