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PRDX5 Gene

protein-coding   GIFtS: 71
GCID: GC11P064085

Peroxiredoxin 5

  See PRDX5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxiredoxin 51 2     EC 1.11.1.153 8
TPx Type VI1 2 3     B1662
Antioxidant Enzyme B1661 2 3     HEL-S-552
Liver Tissue 2D-Page Spot 71B1 2 3     PMP202
Peroxisomal Antioxidant Enzyme1 2 3     PRDX62
Thioredoxin Peroxidase PMP201 2 3     PRXV2
AOEB1662 3 5     Epididymis Secretory Protein Li 552
Alu Co-Repressor 11 2     Peroxiredoxin-5, Mitochondrial2
Peroxiredoxin V2 3     prx-V2
Thioredoxin Reductase2 3     Prx-V3
ACR12 3     Alu Corepressor 13
PLP2 3     

External Ids:    HGNC: 93551   Entrez Gene: 258242   Ensembl: ENSG000001264327   OMIM: 6065835   UniProtKB: P300443   

Export aliases for PRDX5 gene to outside databases

Previous GC identifers: GC11P066601 GC11P065767 GC11P064336 GC11P063860 GC11P063842 GC11P060413


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRDX5 Gene:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and
alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under
normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The
crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene
uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms.
Three transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for PRDX5 Gene:
PRDX5 (peroxiredoxin 5) is a protein-coding gene. Diseases associated with PRDX5 include fuchs' endothelial dystrophy, and corticobasal degeneration. GO annotations related to this gene include peroxidase activity and receptor binding.

UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044
Function: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the
thioredoxin system. Involved in intracellular redox signaling

Gene Wiki entry for PRDX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDX5 gene promoter:
         CREB   PPAR-gamma1   deltaCREB   ATF-2   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDX5 promoter sequence
   Search Chromatin IP Primers for PRDX5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

PRDX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064085:  view genomic region     (about GC identifiers)

Start:
64,085,560 bp from pter      End:
64,089,295 bp from pter
Size:
3,736 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044 (See protein sequence)
Recommended Name: Peroxiredoxin-5, mitochondrial precursor  
Size: 214 amino acids; 22086 Da
Subunit: Monomer
Sequence caution: Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30;
Selected PDB 3D structures from and Proteopedia for PRDX5 (see all 8):
1H4O (3D)        1HD2 (3D)        1OC3 (3D)        1URM (3D)        2VL2 (3D)        2VL3 (3D)    
Secondary accessions: A6NC19 A6NG06 B7ZLJ4 B7ZVW3 Q14CK0 Q6IAF2 Q9UBU5 Q9UJU4 Q9UKX4
Alternative splicing, Alternative initiation: 4 isoforms:  P30044-1   P30044-2   P30044-3   P30044-4   (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for PRDX5: NX_P30044

Explore proteomics data for PRDX5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys83
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRDX5 (P30044) (see all 6)
     VPGAFTP  VEVFEGEPG  KVNLAELFK  FGNRRLKRFSMV 


    See PRDX5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_036226.1  NP_857634.1  NP_857635.1  

    ENSEMBL proteins: 
     ENSP00000265462   ENSP00000335334   ENSP00000335363  
    Reactome Protein details: P30044

    PRDX5 Human Recombinant Protein Products:

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    Novus Biologicals PRDX5 Proteins
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    Sino Biological Recombinant Protein for PRDX5
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    ProSpec Recombinant Protein for PRDX5
    Cloud-Clone Corp. Proteins for PRDX5

     
    Search eBioscience for Proteins for PRDX5 

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    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX5
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    Cloud-Clone Corp. ELISAs for PRDX5
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    Search eBioscience for ELISAs for PRDX5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013740 Redoxin
     IPR012336 Thioredoxin-like_fold

    Graphical View of Domain Structure for InterPro Entry P30044

    ProtoNet protein and cluster: P30044

    2 Blocks protein domains:
    IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
    IPB013740 Redoxin


    UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044
    Similarity: Belongs to the peroxiredoxin 2 family
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with PRDX5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX5_HUMAN, P30044
    Function: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the
    thioredoxin system. Involved in intracellular redox signaling
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

         Enzyme Number (IUBMB): EC 1.11.1.151 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001016RNA polymerase III regulatory region DNA binding IDA10095767
    GO:0004601peroxidase activity IDA10521424
    GO:0005102receptor binding IPI10514471
    GO:0016209antioxidant activity IDA10514471
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with PRDX5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PRDX5:
     Increased G1 DNA content  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRDX5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX5

    miRNA
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    miRTarBase miRNAs that target PRDX5:
    hsa-mir-744-5p (MIRT037717)

    Block miRNA regulation of human, mouse, rat PRDX5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PRDX5:
    hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRDX5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): PRDX5 (NM_012094)
    Sino Biological Human cDNA Clone for PRDX5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRDX5_HUMAN, P30044: Isoform Mitochondrial: Mitochondrion
    PRDX5_HUMAN, P30044: Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion5
    nucleus5
    peroxisome5
    chloroplast2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA10095767
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--

    Find genes that share ontologies with PRDX5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRDX5 About    
    See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    thioredoxin pathway0.00
    2Cellular Senescence
    Cellular responses to stress0.81
    3Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM
    4Peroxisome
    Peroxisome
    5Detoxification of Reactive Oxygen Species
    Detoxification of Reactive Oxygen Species


    Find genes that share SuperPaths with PRDX5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PRDX5
        Prostaglandin 2 biosynthesis and metabolism FM

    2 BioSystems Pathways for PRDX5
        Selenium Pathway
    thioredoxin pathway


    1 Reactome Pathway for PRDX5
        Detoxification of Reactive Oxygen Species


    1 Kegg Pathway  (Kegg details for PRDX5):
        Peroxisome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRDX5: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PRDX5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRDX5 (P300442, 3 ENSP000002654624) via UniProtKB, MINT, STRING, and/or I2D (see all 342)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC90BQ9GZT62, 3, ENSP000002600544MINT-63639 I2D: score=5 STRING: ENSP00000260054
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    BABAM1Q9NWV83, ENSP000003524084I2D: score=2 STRING: ENSP00000352408
    LIN54Q6MZP73, ENSP000003419474I2D: score=1 STRING: ENSP00000341947
    PRDX4Q131622, ENSP000003686464MINT-8079030 STRING: ENSP00000368646
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response TAS10521424
    GO:0006979response to oxidative stress IDA10514471
    GO:0016480negative regulation of transcription from RNA polymerase III promoter IDA10095767
    GO:0032967positive regulation of collagen biosynthetic process IDA15276323
    GO:0034614cellular response to reactive oxygen species IMP18262354

    Find genes that share ontologies with PRDX5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDX5

    2 HMDB Compounds for PRDX5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 DrugBank Compounds for PRDX5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Auranofin-- 34031-32-8targetinhibitor15191400 16036347 19578042 12163349 11752352
    Benzoic Acid-- 65-85-0target--17139284 17016423
    Diminazene1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE (see all 6)536-71-0target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for PRDX5 gene (see all 98)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenocysteine 92.7 56 10833265 (4), 9288405 (3), 9535831 (2), 9671710 (2) (see all 32)
    selenium 84 87 9288405 (4), 9890567 (4), 15509710 (2), 9413175 (2) (see all 51)
    dithiol 83.8 6 10854441 (1), 14563480 (1), 11307155 (1), 19941471 (1) (see all 5)
    auranofin 83.4 9 17320769 (2), 15458826 (1), 16036347 (1), 19878651 (1) (see all 6)
    nadph 80.2 84 8626570 (2), 7876079 (2), 9108027 (2), 7961915 (1) (see all 75)
    motexafin gadolinium 76.2 2 15867382 (1), 16481328 (1)
    selenite 75.7 17 8813134 (2), 17448585 (1), 9288405 (1), 17115890 (1) (see all 14)
    6-biopterin 75.3 3 7945390 (1), 8750928 (1)
    dtnb 73.6 9 9073351 (2), 8070012 (2), 19734126 (1), 9288405 (1) (see all 7)
    selenol 70.2 1 17115886 (1)



    Find genes that share compounds with PRDX5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRDX5 gene (3 alternative transcripts): 
    NM_012094.4  NM_181651.2  NM_181652.2  

    Unigene Cluster for PRDX5:

    Peroxiredoxin 5
    Hs.502823  [show with all ESTs]
    Unigene Representative Sequence: BM462424
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265462(uc001nzu.3 uc001nzv.3 uc001nzw.3) ENST00000352435
    ENST00000347941
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRDX5
      QuantiFast Probe-based Assays in human, mouse, rat PRDX5

    Additional mRNA sequence: 

    AF110731.1 AF112212.1 AF124993.1 AF197952.1 AF231705.1 AF242525.1 AJ249483.1 BC110983.1 
    BC113723.1 BC113725.1 BC143849.1 BC171733.1 CR457203.1 U82616.1 

    21 DOTS entries:

    DT.100661501  DT.95167115  DT.448884  DT.95167121  DT.100661500  DT.120754231  DT.120754247  DT.100661498 
    DT.95167126  DT.120754238  DT.92449993  DT.120754171  DT.120754223  DT.120754225  DT.92449988  DT.92449992 
    DT.95167118  DT.95167124  DT.95167125  DT.97766660  DT.97820845 

    Selected AceView cDNA sequences (see all 828):

    AV696801 BM760930 BQ674944 BM739017 BM747467 CK905058 BM702822 BM662662 
    CD556643 BE790729 CR609622 BG757759 BF664452 BM760651 BG397458 CF132531 
    BM761434 BE886924 BQ956319 BU521326 BQ941699 BM844306 BF725685 AJ249483 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRDX5 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
    SP1:                                -     -     -                                         -                           
    SP2:                                            -                                         -                           
    SP3:                                -     -     -                 -                       -                           
    SP4:                                            -                                                                     
    SP5:                                -     -     -     -     -                             -                           


    ECgene alternative splicing isoforms for PRDX5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRDX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTACAGG
    PRDX5 Expression
    About this image


    PRDX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PRDX5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDX5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502823

    UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRDX5: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PRDX5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDX5
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRDX5 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx51 , 5 peroxiredoxin 51, 5 86.11(n)1
    87.22(a)1
      19 (5.08 cM)5
    546831  NM_012021.21  NP_036151.11 
     69066975 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX56
    peroxiredoxin 5
    66(a)
    1 ↔ 1
    AAWZ02036029(20139-31562)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ039182.12   -- 73.38(n)    BJ039182.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prdx51 peroxiredoxin 5 63.96(n)
    61.25(a)
      554105  NM_001024406.1  NP_001019577.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72173
    Prx51
    antioxidant3
    Peroxiredoxin 51
    57(a)3
    62.37(n)1
    59.51(a)1
      37719511  NM_142422.51  NP_650679.31 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AHP1(YLR109W)4 Thiol-specific peroxiredoxin, reduces hydroperoxides more   --   12(368781-369311) 850799  NP_013210.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TPX11 TPX1 50.53(n)
    43.95(a)
      842910  NM_105270.2  NP_176773.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06751001 Os01g0675100 49.9(n)
    44.03(a)
      4325511  NM_001050380.1  NP_001043845.1 


    ENSEMBL Gene Tree for PRDX5 (if available)
    TreeFam Gene Tree for PRDX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRDX5 gene

    Find genes that share paralogs with PRDX5           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for PRDX5
    PGOHUM00000238543 PGOHUM00000244073 PGOHUM00000241032 PGOHUM00000237650 PGOHUM00000238066


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRDX5 (see all 227)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364064
    A breast cancer sample4--see VAR_0364062 F L mis40--------
    rs3738699861,2
    C--64003010(+) ACGTGC/TCCCAG 3 -- us2k10--------
    rs799414581,2
    F--64003048(+) AGGGGG/ACTGCA 3 -- us2k11Minor allele frequency- A:0.04EA 120
    rs1909926291,2
    --64003239(+) AGTGTC/GCCCCC 3 -- us2k10--------
    rs412944241,2
    C,F--64003274(+) TCCAGC/ACCCTG 3 -- us2k113Minor allele frequency- A:0.13NS NA WA EA 600
    rs32049191,2
    C--64003352(+) TGCCTC/TTATGC 3 -- us2k10--------
    rs1835545151,2
    --64003356(+) TCTATG/TCCCTG 3 -- us2k10--------
    rs1874443711,2
    --64003401(+) GCCAGA/GGAGGC 3 -- us2k10--------
    rs6797301,2
    C,H--64003444(-) TACAGC/TCAAGG 3 -- us2k111Minor allele frequency- T:0.00EA NA MN WA CSA 247
    rs1499840801,2
    --64003523(+) AAAAAA/TATATA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for PRDX5 (64085560 - 64089295 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PRDX5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667562CNV Deletion23128226
    nsv897685CNV Loss21882294
    dgv1165n71CNV Loss21882294
    dgv1166n71CNV Loss21882294
    dgv1156n71CNV Loss21882294
    esv27107CNV Loss19812545
    nsv832186CNV Loss17160897
    dgv1163n71CNV Loss21882294
    nsv469961CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606583    OMIM disorders: --

    3 diseases for PRDX5:    
    About MalaCards
    fuchs' endothelial dystrophy    corticobasal degeneration    malaria

    1 disease from the University of Copenhagen DISEASES database for PRDX5:
    Hermansky-Pudlak syndrome

    Find genes that share disorders with PRDX5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRDX5 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selenium deficiency 77.7 4 12888577 (1), 9288405 (1), 11842884 (1), 9890567 (1)
    cancer 44.3 31 11354308 (2), 14695837 (2), 14604673 (2), 9354464 (1) (see all 27)
    melanoma amelanotic 25.9 2 2200526 (2)
    tumors 25.2 17 16777982 (2), 2065101 (2), 15623470 (1), 16250662 (1) (see all 12)
    adenocarcinoma lung 22.1 3 8722124 (1), 8577704 (1), 10833265 (1)
    vitiligo 21.6 4 17645381 (2), 12823440 (1)
    colon cancer 19.8 2 9413175 (1), 12151345 (1)
    metastatic melanoma 18.3 3 15695408 (1), 1841712 (1)
    lung carcinoma 12.5 5 16781710 (3)
    shock 12 9 17504983 (1), 17590165 (1), 18629638 (1), 18069416 (1) (see all 8)

    Genetic Association Database (GAD): PRDX5
    Human Genome Epidemiology (HuGE) Navigator: PRDX5 (5 documents)

    Export disorders for PRDX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRDX5 gene, integrated from 10 sources (see all 546):
    (articles sorted by number of sources associating them with PRDX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PubMed id 10521424)1, 2, 3, 9 Knoops B.... Bernard A. (J. Biol. Chem. 1999)
    2. Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. (PubMed id 10514471)1, 2, 3 Yamashita H.... Avraham H. (J. Biol. Chem. 1999)
    3. Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5-A resolution. (PubMed id 11518528)1, 2, 9 Declercq J.-P....Knoops B. (J. Mol. Biol. 2001)
    4. Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. (PubMed id 10751410)1, 2, 9 Seo M.S.... Rhee S.G. (J. Biol. Chem. 2000)
    5. Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53- induced apoptosis. (PubMed id 10679306)1, 2, 9 Zhou Y.... Jin D.-Y. (Biochem. Biophys. Res. Commun. 2000)
    6. The crystal structures of oxidized forms of human peroxiredoxin 5 with an intramolecular disulfide bond confirm the proposed enzymatic mechanism for atypical 2-Cys peroxiredoxins. (PubMed id 18489898)1, 2, 9 Smeets A.... Declercq J.P. (Arch. Biochem. Biophys. 2008)
    7. A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase- III-driven transcription of the Alu-family retroposons in vitro. (PubMed id 10095767)1, 2, 9 Kropotov A.... Tomilin N. (Eur. J. Biochem. 1999)
    8. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    9. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)
    10. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PubMed id 20596022)1, 4 Petukhova L....Christiano A.M. (Nature 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25824 HGNC: 9355 AceView: ESRRAandPRDX5 Ensembl:ENSG00000126432 euGenes: HUgn25824
    ECgene: PRDX5 Kegg: 25824 H-InvDB: PRDX5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRDX5 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/prdx5/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRDX5 gene:
    Search GeneIP for patents involving PRDX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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