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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRDX5 Gene

protein-coding GIFtS: 68
GCID: GC11P064085

peroxiredoxin 5

Explore 67 diseases affiliated with
PRDX5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peroxiredoxin 5¹ ²		Thioredoxin Peroxidase PMP20² ³
AOEB166¹ ² ³ ⁵		Thioredoxin Reductase² ³
ACR1¹ ² ³		TPx Type VI² ³
PLP¹ ² ³		EC 1.11.1.15³ ⁸
B166¹ ²		MGC117264¹
PMP20¹ ²		MGC142283¹
PRDX6¹ ²		MGC142285¹
PRXV¹ ²		SBBI10¹
Alu Corepressor 1² ³		Alu Co-Repressor 1²
Antioxidant Enzyme B166² ³		Peroxiredoxin-5, Mitochondrial²
Liver Tissue 2D-Page Spot 71B² ³		Prx-V³
Peroxiredoxin V² ³		Prx-V³
Peroxisomal Antioxidant Enzyme² ³

External Ids:	HGNC: 9355¹	Entrez Gene: 25824²	Ensembl: ENSG00000126432⁷	OMIM: 606583⁵	UniProtKB: P30044³

Export aliases for PRDX5 gene to outside databases

Previous GC identifers: GC11P066601 GC11P065767 GC11P064336 GC11P063860 GC11P063842 GC11P060413

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDX5:

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl

hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal

conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure

of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame

translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants

encoding distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044

Function: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin

system. Involved in intracellular redox signaling

Gene Wiki entry for PRDX5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRDX5 gene promoter:
CREB PPAR-gamma1 deltaCREB ATF-2 PPAR-gamma2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRDX5 promoter sequence

Search SABiosciences Chromatin IP Primers for PRDX5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

PRDX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX5 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P064085: view genomic region (about GC identifiers)

Start:	64,085,560 bp from pter	End:	64,089,283 bp from pter
Size:	3,724 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044 (See protein sequence)

Recommended Name: Peroxiredoxin-5, mitochondrial precursor

Size: 214 amino acids; 22086 Da

Subunit: Monomer

Subcellular location: Isoform Mitochondrial: Mitochondrion

Subcellular location: Isoform Cytoplasmic+peroxisomal: Cytoplasm. Peroxisome

Sequence caution: Sequence=AAF17200.1; Type=Frameshift; Positions=14, 30;

6/8 PDB 3D structures from and Proteopedia for PRDX5 (see all 8):

1H4O (3D)

1HD2 (3D)

1OC3 (3D)

1URM (3D)

2VL2 (3D)

2VL3 (3D)

Secondary accessions: A6NG06 B7ZLJ4 Q14CK0 Q6IAF2 Q9UBU5 Q9UJU4 Q9UKX4

Alternative initiation: 3 isoforms: P30044-1 P30044-2 P30044-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRDX5: NX_P30044

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30044

4/6 DME Specific Peptides for PRDX5 (P30044) (see all 6)

VPGAFTP

VEVFEGEPG

KVNLAELFK

FGNRRLKRFSMV

PRDX5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_036226.1 NP_857634.1 NP_857635.1

ENSEMBL proteins:

ENSP00000265462 ENSP00000335334 ENSP00000335363

Human Recombinant Protein Products for PRDX5:

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	Novus Biologicals PRDX5 Proteins Novus Biologicals PRDX5 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for PRDX5
	Uscn Proteins for PRDX5

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	15785239
GO:0005737	cytoplasm	IDA	10514471
GO:0005739	mitochondrion	IDA	10751410
GO:0005777	peroxisome	IDA	10751410
GO:0005782	peroxisomal matrix	IDA	10514471

PRDX5 for ontologies About GeneDecksing

PRDX5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX5
	R&D Systems Antibodies for PRDX5 (Peroxiredoxin 5)
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	Novus Biologicals PRDX5 Antibodies
	Abcam antibodies for PRDX5
	Uscn Antibodies for PRDX5
	ThermoFisher Antibodies for PRDX5

Assay Products for PRDX5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PRDX5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PRDX5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRDX5 for domains About GeneDecksing

2 InterPro domains/families:

IPR013740 Redoxin

IPR012336 Thioredoxin-like_fold

Graphical View of Domain Structure for InterPro Entry P30044

ProtoNet protein and cluster: P30044

2 Blocks protein families:

IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

IPB013740 Redoxin

UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044

Similarity: Belongs to the peroxiredoxin 2 family

Similarity: Contains 1 thioredoxin domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PRDX5_HUMAN, P30044

Function: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin

system. Involved in intracellular redox signaling

Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

Enzyme Number (IUBMB): EC 1.11.1.15¹ ²

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001016	RNA polymerase III regulatory region DNA binding	IDA	10095767
GO:0004601	peroxidase activity	IDA	10521424
GO:0005102	receptor binding	IPI	--
GO:0016209	antioxidant activity	IDA	10514471
GO:0016491	oxidoreductase activity	--	--

PRDX5 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PRDX5:

Increased G1 DNA content

Increased homologous recombina

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRDX5

miRNA Products:		miRTarBase miRNAs that target PRDX5: hsa-mir-632 (MIRT004940)

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate PRDX5:
		hsa-miR-298
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PRDX5
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX5 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Prostaglandin 2 biosynthesis and metabolism FM

0.44

Prostaglandin 2 biosynthesis and metabolism FM

0.44

Selenium Pathway

Selenium Pathway

1.00

thioredoxin pathway

thioredoxin pathway

1.00

Peroxisome

Peroxisome

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PRDX5

Prostaglandin 2 biosynthesis and metabolism FM

1 GeneGo (Thomson Reuters) Pathway for PRDX5

Prostaglandin 2 biosynthesis and metabolism FM

2 BioSystems Pathways for PRDX5

	Selenium Pathway
	thioredoxin pathway

1 Kegg Pathway (Kegg details for PRDX5):

Peroxisome

PRDX5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRDX5

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/256 Interacting proteins for PRDX5 (P30044^{2, 3} ENSP00000265462⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 256)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
CCDC90B	Q9GZT6²^,³, ENSP00000260054⁴	MINT-63639 I2D: score=5 STRING: ENSP00000260054
BABAM1	Q9NWV8³, ENSP00000352408⁴	I2D: score=2 STRING: ENSP00000352408
LIN54	Q6MZP7³, ENSP00000341947⁴	I2D: score=1 STRING: ENSP00000341947
SUFU	Q9UMX1³, ENSP00000358918⁴	I2D: score=2 STRING: ENSP00000358918

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	TAS	10521424
GO:0006979	response to oxidative stress	IDA	10514471
GO:0016480	negative regulation of transcription from RNA polymerase III promoter	IDA	10095767
GO:0032967	positive regulation of collagen biosynthetic process	IDA	15276323
GO:0034614	cellular response to reactive oxygen species	IMP	18262354

PRDX5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRDX5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRDX5

2 HMDB Compounds for PRDX5 About this table

Compound	Synonyms	CAS #	PubMed Ids
Hydrogen peroxide	Hydrogen peroxide (see all 44)	7722-84-1	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

3 DrugBank Compounds for PRDX5 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Auranofin	--	34031-32-8	target	inhibitor	15191400 16036347 19578042 12163349 11752352
Benzoic Acid	--	65-85-0	target	--	17139284 17016423
Diminazene	1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE (see all 6)	536-71-0	target	--	17139284 17016423

10/98 Novoseek chemical compound relationships for PRDX5 gene (see all 98) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
selenocysteine	92.7	56	10833265 (4), 9288405 (3), 9535831 (2), 9671710 (2) (see all 32)
selenium	84	87	9288405 (4), 9890567 (4), 15509710 (2), 9413175 (2) (see all 51)
dithiol	83.8	6	10854441 (1), 14563480 (1), 11307155 (1), 19941471 (1) (see all 5)
auranofin	83.4	9	17320769 (2), 15458826 (1), 16036347 (1), 19878651 (1) (see all 6)
nadph	80.2	84	8626570 (2), 7876079 (2), 9108027 (2), 7961915 (1) (see all 75)
motexafin gadolinium	76.2	2	15867382 (1), 16481328 (1)
selenite	75.7	17	8813134 (2), 17448585 (1), 9288405 (1), 17115890 (1) (see all 14)
6-biopterin	75.3	3	7945390 (1), 8750928 (1)
dtnb	73.6	9	9073351 (2), 8070012 (2), 19734126 (1), 9288405 (1) (see all 7)
selenol	70.2	1	17115886 (1)

Search CenterWatch for drugs/clinical trials and news about PRDX5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRDX5 gene (3 alternative transcripts):

NM_012094.4 NM_181651.2 NM_181652.2

Unigene Cluster for PRDX5:

Peroxiredoxin 5

Hs.502823 [show with all ESTs]

Unigene Representative Sequence: BM462424

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265462(uc001nzu.3 uc001nzv.3 uc001nzw.3) ENST00000352435

ENST00000347941

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PRDX5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX5
		1 QIAGEN miScript miRNA Assays for microRNA that regulate PRDX5:
		hsa-miR-298
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PRDX5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX5 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRDX5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDX5

Additional cDNA sequence:

AF110731.1 AF112212.1 AF124993.1 AF197952.1 AF231705.1 AF242525.1 AJ249483.1 BC110983.1

BC113723.1 BC113725.1 BC143849.1 BC171733.1 CR457203.1 U82616.1

21 DOTS entries:

DT.100661501 DT.95167115 DT.448884 DT.95167121 DT.100661500 DT.120754231 DT.120754247 DT.100661498

DT.95167126 DT.120754238 DT.92449993 DT.120754171 DT.120754223 DT.120754225 DT.92449988 DT.92449992

DT.95167118 DT.95167124 DT.95167125 DT.97766660 DT.97820845

24/828 AceView cDNA sequences (see all 828):

BE278200 BU528679 BE250703 AW328550 BM739044 BC073956 AI220129 BU732071

BM760173 BE278209 BM850193 CK905059 BF725685 BM791758 BC007915 CR609622

BE773390 BG744031 BI497310 BG397651 AJ249483 BQ932063 BF343659 BG747925

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX5 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	·	7d
SP1:											-		-		-														-
SP2:															-														-
SP3:											-		-		-						-								-
SP4:															-
SP5:											-		-		-		-		-										-

ECgene alternative splicing isoforms for PRDX5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRDX5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGTACAGG

About this image

PRDX5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRDX5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRDX5

SOURCE GeneReport for Unigene cluster: Hs.502823

UniProtKB/Swiss-Prot: PRDX5_HUMAN, P30044

Tissue specificity: Widely expressed

SABiosciences Expression via Pathway-Focused PCR Arrays including PRDX5:

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDX5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX5 gene from 8/30 species (see all 30) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Prdx5^{1 , 5}	peroxiredoxin 5^{1, 5}	84.31(n)¹ 85.56(a)¹		19 (5.08 cM)⁵ 54683¹ NM_012021.2¹ NP_036151.1¹ 6906697⁵
lizard (Anolis carolinensis)	Reptilia	PRDX5⁶	--	63(a)	1 ↔ 1	AAWZ02036029(20109-28281)
African clawed frog (Xenopus laevis)	Amphibia	BJ039182.1²	--	73.38(n)		BJ039182.1
zebrafish (Danio rerio)	Actinopterygii	prdx5¹	peroxiredoxin 5	63.96(n) 61.25(a)		554105 NM_001024406.1 NP_001019577.1
fruit fly (Drosophila melanogaster)	Insecta	CG7217³ CG7215¹	antioxidant³ CG7215¹	57(a)³ 62.37(n)¹ 59.51(a)¹		3772662¹ NM_001032020.2¹ NP_001027191.1¹
A. gossypii yeast (Ashbya gossypii)	Saccharomycetes	AGOS_ADL154C¹	ADL154Cp	46.74(n) 38.14(a)		4620084 NM_209295.1 NP_983942.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G52960¹	peroxiredoxin-2E	47.13(n) 40.23(a)		824462 NM_115156.2 NP_190864.1
rice (Oryza sativa)	Liliopsida	Os02g0192700¹	hypothetical protein	51.35(n) 43.24(a)		4328586 NM_001052700.1 NP_001046165.1

ENSEMBL Gene Tree for PRDX5 (if available)
TreeFam Gene Tree for PRDX5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRDX5 gene

PRDX5 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for PRDX5
PGOHUM00000238543 PGOHUM00000244073 PGOHUM00000241032 PGOHUM00000237650 PGOHUM00000238066

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs41294426^1,2	C,F	--	64084728(+)	`TAAGGA/GTCCTC`	4	--	us2k¹ int¹		10		NS	380
rs140189524^1,2		--	64084856(+)	`GAGTTG/TAGGCA`	4	--	int¹ us2k¹		0	--	--	--	--
rs28699214^1,2	C,F,H	--	64084884(+)	`CACCAT/CCCCGC`	4	--	int¹ us2k¹		3		NS NA	290
rs41294430^1,2	C,F	--	64085006(+)	`CGCCGC/AACAAA`	4	--	us2k¹ ut5¹		10		NS	378
rs10128595^1,2	C,F,H	--	64085056(+)	`TGCCTC/AACTTC`	4	--	us2k¹ tfbs³		24		NS EA NA WA	2380
rs4930698^1,2	C,F,A	--	64085063(+)	`CTTCCG/CGGGAT`	4	--	us2k¹ tfbs³		16		NA NS EA	930
rs550819^1,2	C,F,A,H	--	64085074(-)	`TCGAGT/AGGAGC`	4	--	us2k¹		29		MN NA NS EA WA CSA	1261
rs41294432^1,2	C,F	--	64085081(+)	`TCGATG/ACTATT`	4	--	us2k¹		10		NS	380
rs41294434^1,2	C,F	--	64085110(+)	`AAGTGG/-CGAAC`	4	--	us2k¹		10		NS	376
rs28364831^1,2	C,F	--	64085148(+)	`AGCTGA/CGGTAG`	4	--	us2k¹		14		MN EA NS NA	1872

HapMap Linkage Disequilibrium report for PRDX5 (64085560 - 64089283 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PRDX5
1 CNV: 65971

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRDX5 for disorders           About GeneDecksing

OMIM gene information: 606583    OMIM disorders: --

20/67 diseases for PRDX5 (see all 67):    About MalaCards

fuchs' endothelial dystrophy hermansky-pudlak syndrome non-small cell lung carcinoma pre-eclampsia

malignant pleural mesothelioma corticobasal degeneration alopecia areata xeroderma pigmentosum

coronary heart disease adult t-cell leukemia rheumatoid arthritis vitiligo

alopecia brain disease lung carcinoma renal cell carcinoma

cataract cystic fibrosis eclampsia diphtheria

1 disease from the University of Copenhagen DISEASES database for PRDX5:

Hermansky-Pudlak syndrome

10/36 Novoseek disease relationships for PRDX5 gene (see all 36) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
selenium deficiency	77.7	4	12888577 (1), 9288405 (1), 11842884 (1), 9890567 (1)
cancer	44.3	31	11354308 (2), 14695837 (2), 14604673 (2), 9354464 (1) (see all 27)
melanoma amelanotic	25.9	2	2200526 (2)
tumors	25.2	17	16777982 (2), 2065101 (2), 15623470 (1), 16250662 (1) (see all 12)
adenocarcinoma lung	22.1	3	8722124 (1), 8577704 (1), 10833265 (1)
vitiligo	21.6	4	17645381 (2), 12823440 (1)
colon cancer	19.8	2	9413175 (1), 12151345 (1)
metastatic melanoma	18.3	3	15695408 (1), 1841712 (1)
lung carcinoma	12.5	5	16781710 (3)
shock	12	9	17504983 (1), 17590165 (1), 18629638 (1), 18069416 (1) (see all 8)

Human Genome Epidemiology (HuGE) Navigator: PRDX5 (5 documents)

Export disorders for PRDX5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRDX5 gene, integrated from 9 sources (see all 539):
(articles sorted by number of sources associating them with PRDX5)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family. (PubMed id 10521424)^{1, 2, 3, 9} Knoops B.... Bernard A. (1999)
Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro. (PubMed id 10514471)^{1, 2, 3} Yamashita H.... Avraham H. (1999)
Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5-A resolution. (PubMed id 11518528)^{1, 2, 9} Declercq J.-P....Knoops B. (2001)
Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. (PubMed id 10751410)^{1, 2, 9} Seo M.S.... Rhee S.G. (2000)
Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53- induced apoptosis. (PubMed id 10679306)^{1, 2, 9} Zhou Y.... Jin D.-Y. (2000)
A novel human DNA-binding protein with sequence similarity to a subfamily of redox proteins which is able to repress RNA-polymerase- III-driven transcription of the Alu-family retroposons in vitro. (PubMed id 10095767)^{1, 2, 9} Kropotov A.... Tomilin N. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)^{1, 2} Hu R.-M.... Chen J.-L. (2000)
Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)^{1, 2} Hochstrasser D.F.... Hughes G.J. (1992)
Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides. (PubMed id 14732291)^{1, 9} Banmeyer I....Knoops B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25824	HGNC: 9355	AceView: ESRRAandPRDX5	Ensembl:ENSG00000126432	euGenes: HUgn25824
ECgene: PRDX5	Kegg: 25824	H-InvDB: PRDX5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRDX5	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/prdx5/

Intellectual Property for PRDX5 gene
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Patent Information for PRDX5 gene:
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GeneCards and IP:
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PRDX5 Gene

peroxiredoxin 5

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PRDX5 (Gene Symbol)
Peroxiredoxin 5
AOEB166
ACR1
PLP
B166
PMP20
PRDX6
PRXV
Alu Corepressor 1
Antioxidant Enzyme B166
Liver Tissue 2D-Page Spot 71B
Peroxiredoxin V
Peroxisomal Antioxidant Enzyme
Thioredoxin Peroxidase PMP20
Thioredoxin Reductase
TPx Type VI
EC 1.11.1.15
MGC117264
MGC142283
MGC142285
SBBI10
Alu Co-Repressor 1
Peroxiredoxin-5, Mitochondrial
Prx-V
Prx-V

Melanoma
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primary tumor
Cataract
HEPATOCELLULAR CARCINOMA
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metastatic melanoma
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small cell lung cancer
Carcinoma Non-Small Cell Lung
Shock
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PRDX5 Gene

peroxiredoxin 5

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