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PRDX4 Gene

protein-coding   GIFtS: 69
GCID: GC0XP023592

Peroxiredoxin 4

  See PRDX4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxiredoxin 41 2     HEL-S-97n2
Antioxidant Enzyme AOE3722 3     PRX-42
Peroxiredoxin IV2 3     Epididymis Secretory Sperm Binding Protein Li 97n2
Thioredoxin Peroxidase AO3722 3     peroxiredoxin-42
Thioredoxin-Dependent Peroxide Reductase A03722 3     prx-IV2
AOE37-22 3     Thioredoxin Peroxidase (Antioxidant Enzyme)2
EC 1.11.1.153 8     Prx-IV3

External Ids:    HGNC: 171691   Entrez Gene: 105492   Ensembl: ENSG000001231317   OMIM: 6065065   UniProtKB: Q131623   

Export aliases for PRDX4 gene to outside databases

Previous GC identifers: GC0XP022492 GC0XP022256 GC0XP022884 GC0XP023047 GC0XP023445 GC0XP021425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRDX4 Gene:
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is
localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl
hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor
molecules. This protein has been found to play a regulatory role in the activation of the transcription factor
NF-kappaB. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRDX4 Gene:
PRDX4 (peroxiredoxin 4) is a protein-coding gene. Diseases associated with PRDX4 include cystic echinococcosis. GO annotations related to this gene include thioredoxin peroxidase activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol
by a modulation of I-kappa-B-alpha phosphorylation

Gene Wiki entry for PRDX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDX4 gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   Meis-1b   MEF-2A   c-Jun   aMEF-2   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDX4 promoter sequence
   Search Chromatin IP Primers for PRDX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

PRDX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP023592:  view genomic region     (about GC identifiers)

Start:
23,682,379 bp from pter      End:
23,704,516 bp from pter
Size:
22,138 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162 (See protein sequence)
Recommended Name: Peroxiredoxin-4 precursor  
Size: 271 amino acids; 30540 Da
Subunit: Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (By similarity)
Miscellaneous: The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with
Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The
enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Irreversibly inactivated by overoxidation of Cys-124 (to Cys-SO(3)H) upon oxidative stress
Selected PDB 3D structures from and Proteopedia for PRDX4 (see all 10):
2PN8 (3D)        3TJB (3D)        3TJF (3D)        3TJG (3D)        3TJJ (3D)        3TJK (3D)    
Secondary accessions: Q6FHT3

Explore the universe of human proteins at neXtProt for PRDX4: NX_Q13162

Explore proteomics data for PRDX4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys208
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRDX4 (Q13162) (see all 10)
     VGRSVDE  DFTFVCP  HGEVCPA  NDLPVGR 


    See PRDX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006397.1  
    ENSEMBL proteins: 
     ENSP00000368654   ENSP00000368646   ENSP00000368635   ENSP00000413736  

    PRDX4 Human Recombinant Protein Products:

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    Novus Biologicals PRDX4 Proteins
    Novus Biologicals PRDX4 Lysates
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRDX4
    Cloud-Clone Corp. Proteins for PRDX4

     
    Search eBioscience for Proteins for PRDX4 

    PRDX4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX4
    R&D Systems Antibodies for PRDX4 (Peroxiredoxin 4)
    OriGene Antibodies for PRDX4
    OriGene Custom Antibody Services for PRDX4
    Novus Biologicals PRDX4 Antibodies
    Abcam antibodies for PRDX4 (P30044, Q06830, Q13162)
    Cloud-Clone Corp. Antibodies for PRDX4
    ThermoFisher Antibody for PRDX4
    LSBio Antibodies in human, mouse, rat for PRDX4

    PRDX4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRDX4
    Cloud-Clone Corp. CLIAs for PRDX4
    Search eBioscience for ELISAs for PRDX4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry Q13162

    ProtoNet protein and cluster: Q13162

    1 Blocks protein domain: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
    Similarity: Belongs to the AhpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with PRDX4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX4_HUMAN, Q13162
    Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol
    by a modulation of I-kappa-B-alpha phosphorylation
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

         Enzyme Number (IUBMB): EC 1.11.1.151 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17644091
    GO:0008379thioredoxin peroxidase activity TAS9388242
    GO:0016209antioxidant activity ----
    GO:0016491oxidoreductase activity ----
    GO:0051920peroxiredoxin activity ----
         
    Find genes that share ontologies with PRDX4           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prdx4):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with PRDX4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prdx4tm1.1Jufu for PRDX4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRDX4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRDX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX4

    miRNA
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    miRTarBase miRNAs that target PRDX4:
    hsa-mir-3619-5p (MIRT052859), hsa-mir-222-3p (MIRT046583), hsa-mir-615-3p (MIRT039796), hsa-mir-1229-3p (MIRT036386), hsa-mir-769-5p (MIRT039210), hsa-mir-484 (MIRT041872)

    Block miRNA regulation of human, mouse, rat PRDX4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRDX4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRDX4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for PRDX4 (see all 7)
    OriGene ORF clones in mouse, rat for PRDX4
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    GenScript: all cDNA clones in your preferred vector: PRDX4 (NM_006406)
    Sino Biological Human cDNA Clone for PRDX4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRDX4_HUMAN, Q13162: Cytoplasm. Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    endoplasmic reticulum2
    mitochondrion2
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with PRDX4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRDX4 About    
    See pathways by source

    SuperPathContained pathways About
    1Selenium Pathway
    Selenium Pathway
    2Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PRDX4
        Prostaglandin 2 biosynthesis and metabolism FM

    1 BioSystems Pathway for PRDX4
        Selenium Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including PRDX4: 
              Oxidative Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRDX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRDX4 (Q131621, 2, 3 ENSP000003686464) via UniProtKB, MINT, STRING, and/or I2D (see all 398)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P4HBP072371, 2, 3, ENSP000003278014EBI-2211957,EBI-395883 MINT-8091005 MINT-8091054 I2D: score=1 STRING: ENSP00000327801
    PDIA6Q150841, 2, 3, ENSP000002722274EBI-2211957,EBI-1043087 MINT-8091076 MINT-8091095 I2D: score=1 STRING: ENSP00000272227
    ATP5BP065762, 3, ENSP000002620304MINT-8079030 I2D: score=1 STRING: ENSP00000262030
    DUSP23Q9BVJ72, 3MINT-8254721 I2D: score=2 
    HDAC6Q9UBN72, 3MINT-8258098 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007252I-kappaB phosphorylation TAS9388242
    GO:0007283spermatogenesis IEA--
    GO:0008584male gonad development IEA--
    GO:0055114oxidation-reduction process ----
    GO:0072593reactive oxygen species metabolic process IEA--

    Find genes that share ontologies with PRDX4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDX4

    1 HMDB Compound for PRDX4    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for PRDX4 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 57.6 15 9388242 (2), 18052930 (2), 12861054 (1), 15818395 (1) (see all 10)
    cysteine 50.6 3 19526557 (1), 11764930 (1), 17434115 (1)
    glyceraldehyde 3-phosphate 45.5 4 12622818 (1), 16431015 (1), 16947118 (1), 20450584 (1)
    oxygen 40.3 5 11229364 (2), 17210455 (1), 14648077 (1), 10731722 (1)
    nadph 37.7 2 18461048 (1), 20306272 (1)
    tert-butylhydroperoxide 32.2 1 15347790 (1)
    malate 21.3 2 16431015 (1), 16947118 (1)
    gdp 19.7 1 11981867 (1)
    serine 18.4 3 18838535 (1)
    superoxide 17.9 6 18461048 (1), 20306272 (1), 14648077 (1), 16431015 (1) (see all 5)

    1 PharmGKB related drug/compound annotation for PRDX4 gene    About this table
    Drug/compound PharmGKB Annotation
    docetaxelCA  



    Find genes that share compounds with PRDX4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRDX4 gene: 
    NM_006406.1  

    Unigene Cluster for PRDX4:

    Peroxiredoxin 4
    Hs.83383  [show with all ESTs]
    Unigene Representative Sequence: CD579519
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379349 ENST00000379341(uc004dam.3) ENST00000495599 ENST00000379331
    ENST00000439422
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PRDX4
      QuantiFast Probe-based Assays in human, mouse, rat PRDX4

    Additional mRNA sequence: 

    BC003609.2 BC007107.1 BC016770.1 CR541668.1 CR541705.1 U25182.1 

    11 DOTS entries:

    DT.100797810  DT.86841214  DT.91769555  DT.97763798  DT.418270  DT.91769554  DT.100043017  DT.91916914 
    DT.92407979  DT.91989407  DT.97790799 

    Selected AceView cDNA sequences (see all 356):

    AI221075 BM835065 BM713987 AI133226 BG260175 BI755240 BM746949 BM678350 
    AA693955 BQ182908 BG285084 BM788986 BM450964 BM828389 H91993 CD239897 
    W67518 BP871004 CR594904 BM770036 CR619377 BU628309 CA425779 AA459663 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
    SP1:                                      -                 -                                 
    SP2:                                -     -                 -                                 
    SP3:                                                        -                                 
    SP4:        -     -     -     -     -     -                 -                                 
    SP5:                                      -                                                   


    ECgene alternative splicing isoforms for PRDX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRDX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTTGAT
    PRDX4 Expression
    About this image


    PRDX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
    PRDX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.83383
        Pathway & Disease-focused RT2 Profiler PCR Array including PRDX4: 
              Oxidative Stress in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for PRDX4
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    QuantiFast Probe-based Assays in human, mouse, rat PRDX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRDX4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx41 , 5 peroxiredoxin 41, 5 89.08(n)1
    94.96(a)1
      X (72.38 cM)5
    533811  NM_016764.41  NP_058044.11 
     1553239185 
    chicken
    (Gallus gallus)
    Aves PRDX41 peroxiredoxin 4 81.6(n)
    91.86(a)
      418601  XM_416800.4  XP_416800.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX46
    peroxiredoxin 4
    76(a)
    1 ↔ 1
    3(125627283-125643103)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146022 Xenopus laevis transcribed sequence with strong similarity more 81.75(n)    BX844818.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb59c092 wufb59c09 79.74(n)   322377  CK399401.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jafrac21 , 3 antioxidant3
    thioredoxin peroxidase 21
    69(a)
    (best of 4)3
    64.36(n)1
    70.97(a)1
      63A33
    535771  NM_001274421.11  NP_001261350.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TSA16
    TSA26
    Thioredoxin peroxidase, acts as both a ribosome-as...
    Stress inducible cytoplasmic thioredoxin peroxidas...
    55(a)
    53(a)
    many ↔ many
    many ↔ many
    XIII(220138-220728) YML028W
    IV(1365072-1365662) YDR453C


    ENSEMBL Gene Tree for PRDX4 (if available)
    TreeFam Gene Tree for PRDX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRDX4 gene
    PRDX32  PRDX12  PRDX22  
    3 SIMAP similar genes for PRDX4 using alignment to 4 protein entries:     PRDX4_HUMAN (see all proteins):
    PRDX3    PRDX2    PRDX1

    Find genes that share paralogs with PRDX4           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PRDX4
    PGOHUM00000245509 PGOHUM00000260055


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PRDX4 (see all 409)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26653671,2
    C,H--23598025(-) AAAAAT/ATTTTT 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs732092571,2
    C--23598079(+) GGGCAT/CCCTGG 1 -- us2k12Minor allele frequency- C:0.00NA 3
    rs110949371,2
    C,A,H--23598211(+) GAATTG/ACTTGA 1 -- us2k16Minor allele frequency- A:0.11NA WA CSA 9
    rs21091421,2
    C--23598278(-) CTCGCC/TCTGTC 1 -- us2k13Minor allele frequency- T:0.00NA 5
    rs1880911741,2
    --23598412(+) TTTCAG/TGTTAG 1 -- us2k10--------
    rs25326251,2
    C,F,A,H--23598569(-) AAACTA/GACCTT 1 -- us2k118Minor allele frequency- G:0.13NS EA NA WA CSA 1985
    rs752025751,2
    C--23598577(+) TTTCCC/TTTTGA 1 -- us2k10--------
    rs1919272781,2
    --23598596(+) GGGTGC/GCGTGG 1 -- us2k10--------
    rs1841475201,2
    --23598660(+) GGCGGA/CGAGGG 1 -- us2k10--------
    rs37952201,2
    C,F,A,H--23598685(+) ATGGTA/GGGAAG 1 -- us2k118Minor allele frequency- G:0.62NS EA NA 1975

    HapMap Linkage Disequilibrium report for PRDX4 (23682379 - 23704516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRDX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526897CNV Gain19592680

    Human Gene Mutation Database (HGMD): PRDX4
    Locus Specific Mutation Databases (LSDB): PRDX4

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDX4
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606506    OMIM disorders: --

    1 disease for PRDX4:    
    About MalaCards
    cystic echinococcosis


    Find genes that share disorders with PRDX4           About GenesLikeMe

    9 Novoseek inferred disease relationships for PRDX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 14.1 5 12748950 (1), 15952740 (1), 18306929 (1), 18068167 (1)
    cancer 13.3 3 18272409 (1), 18220333 (1), 18366394 (1)
    glioblastoma 11 1 17233837 (1)
    leukemia 0 1 17656256 (1)
    inflammation 0 1 16720350 (1)
    breast cancer 0 1 18272409 (1)
    hepatocellular carcinoma 0 1 17552011 (1)
    adenocarcinoma 0 1 15239128 (1)
    tumors 0 1 15239128 (1)

    Genetic Association Database (GAD): PRDX4
    Human Genome Epidemiology (HuGE) Navigator: PRDX4 (4 documents)

    Export disorders for PRDX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRDX4 gene, integrated from 10 sources (see all 154):
    (articles sorted by number of sources associating them with PRDX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PubMed id 9388242)1, 2, 3, 9 Jin D.-Y.... Jeang K.-T. (J. Biol. Chem. 1997)
    2. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (Pharmacogenomics J. 2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. (PubMed id 12059788)1, 2 Wagner E.... Rabilloud T. (Biochem. J. 2002)
    7. TNF-related apoptosis-inducing ligand suppresses PRDX4 expression. (PubMed id 19364504)1, 9 Wang H.Q....Zhang H.Y. (FEBS Lett. 2009)
    8. Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. (PubMed id 18052930)1, 9 Tavender T.J....Bulleid N.J. (Biochem. J. 2008)
    9. Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. (PubMed id 18272409)1, 9 Lee S.U....Kim S.H. (Cell Biol. Int. 2008)
    10. Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15952740)1, 9 Ahmed M....Bergsten P. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10549 HGNC: 17169 AceView: PRDX4 Ensembl:ENSG00000123131 euGenes: HUgn10549
    ECgene: PRDX4 H-InvDB: PRDX4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PRDX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PRDX4 gene:
    Search GeneIP for patents involving PRDX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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