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Aliases for PRDX4 Gene

Aliases for PRDX4 Gene

  • Peroxiredoxin 4 2 3
  • Thioredoxin-Dependent Peroxide Reductase A0372 3 4
  • Thioredoxin Peroxidase AO372 3 4
  • Antioxidant Enzyme AOE372 3 4
  • Peroxiredoxin IV 3 4
  • EC 1.11.1.15 4 63
  • AOE37-2 3 4
  • Prx-IV 3 4
  • Epididymis Secretory Sperm Binding Protein Li 97n 3
  • Thioredoxin Peroxidase (Antioxidant Enzyme) 3
  • Peroxiredoxin-4 3
  • HEL-S-97n 3
  • AOE372 3
  • PRX-4 3

External Ids for PRDX4 Gene

Summaries for PRDX4 Gene

Entrez Gene Summary for PRDX4 Gene

  • The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDX4 Gene

PRDX4 (Peroxiredoxin 4) is a Protein Coding gene. Diseases associated with PRDX4 include cystic echinococcosis. Among its related pathways are Selenium Pathway and Prostaglandin 2 biosynthesis and metabolism FM. GO annotations related to this gene include thioredoxin peroxidase activity. An important paralog of this gene is PRDX2.

UniProtKB/Swiss-Prot for PRDX4 Gene

  • Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Gene Wiki entry for PRDX4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX4 Gene

Genomics for PRDX4 Gene

Genomic Location for PRDX4 Gene

Start:
23,664,260 bp from pter
End:
23,686,399 bp from pter
Size:
22,140 bases
Orientation:
Plus strand

Genomic View for PRDX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX4 Gene

Regulatory Elements for PRDX4 Gene

Proteins for PRDX4 Gene

  • Protein details for PRDX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13162-PRDX4_HUMAN
    Recommended name:
    Peroxiredoxin-4
    Protein Accession:
    Q13162
    Secondary Accessions:
    • Q6FHT3

    Protein attributes for PRDX4 Gene

    Size:
    271 amino acids
    Molecular mass:
    30540 Da
    Quaternary structure:
    • Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation.
    Miscellaneous:
    • Irreversibly inactivated by overoxidation of Cys-124 (to Cys-SO(3)H) upon oxidative stress
    • The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin

    Three dimensional structures from OCA and Proteopedia for PRDX4 Gene

neXtProt entry for PRDX4 Gene

Proteomics data for PRDX4 Gene at MOPED

Selected DME Specific Peptides for PRDX4 Gene

Post-translational modifications for PRDX4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys208

Other Protein References for PRDX4 Gene

Domains for PRDX4 Gene

Suggested Antigen Peptide Sequences for PRDX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13162

UniProtKB/Swiss-Prot:

PRDX4_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • Q13162
Family:
  • Belongs to the AhpC/TSA family.:
    • Q13162
genes like me logo Genes that share domains with PRDX4: view

No data available for Gene Families for PRDX4 Gene

Function for PRDX4 Gene

Molecular function for PRDX4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH
UniProtKB/Swiss-Prot Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Enzyme Numbers (IUBMB) for PRDX4 Gene

Gene Ontology (GO) - Molecular Function for PRDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17644091
GO:0008379 thioredoxin peroxidase activity TAS 9388242
GO:0016209 antioxidant activity --
GO:0016491 oxidoreductase activity --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with PRDX4: view
genes like me logo Genes that share phenotypes with PRDX4: view

Animal Models for PRDX4 Gene

MGI Knock Outs for PRDX4:

No data available for Transcription Factor Targeting and HOMER Transcription for PRDX4 Gene

Localization for PRDX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX4 Gene

Cytoplasm. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX4 Gene COMPARTMENTS Subcellular localization image for PRDX4 gene
Compartment Confidence
extracellular 5
cytosol 3
endoplasmic reticulum 2
mitochondrion 2
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum --
genes like me logo Genes that share ontologies with PRDX4: view

Pathways for PRDX4 Gene

genes like me logo Genes that share pathways with PRDX4: view

Pathways by source for PRDX4 Gene

1 GeneGo (Thomson Reuters) pathway for PRDX4 Gene
1 BioSystems pathway for PRDX4 Gene

Gene Ontology (GO) - Biological Process for PRDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007252 I-kappaB phosphorylation TAS 9388242
GO:0007283 spermatogenesis IEA --
GO:0008584 male gonad development IEA --
GO:0019471 4-hydroxyproline metabolic process IEA --
GO:0022417 protein maturation by protein folding IEA --
genes like me logo Genes that share ontologies with PRDX4: view

Compounds for PRDX4 Gene

(1) HMDB Compounds for PRDX4 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5

(15) Novoseek inferred chemical compound relationships for PRDX4 Gene

Compound -log(P) Hits PubMed IDs
h2o2 57.6 12
cysteine 50.6 3
glyceraldehyde 3-phosphate 45.5 4
oxygen 40.3 5
nadph 37.7 2

(1) PharmGKB related drug/compound annotations for PRDX4 Gene

Drug/compound Annotation
docetaxel CA
genes like me logo Genes that share compounds with PRDX4: view

Transcripts for PRDX4 Gene

Unigene Clusters for PRDX4 Gene

Peroxiredoxin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: -

Relevant External Links for PRDX4 Gene

GeneLoc Exon Structure for
PRDX4
ECgene alternative splicing isoforms for
PRDX4

Expression for PRDX4 Gene

mRNA expression in normal human tissues for PRDX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRDX4 Gene

This gene is overexpressed in Pancreas (7.1) and Liver (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX4 Gene

SOURCE GeneReport for Unigene cluster for PRDX4 Gene Hs.83383

genes like me logo Genes that share expressions with PRDX4: view

No data available for mRNA Expression by UniProt/SwissProt for PRDX4 Gene

Orthologs for PRDX4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDX4 35
  • 90.79 (n)
  • 93.77 (a)
PRDX4 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX4 35
  • 89.18 (n)
  • 92.99 (a)
PRDX4 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdx4 35
  • 89.08 (n)
  • 94.96 (a)
Prdx4 16
Prdx4 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDX4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX4 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx4 35
  • 90.34 (n)
  • 94.54 (a)
chicken
(Gallus gallus)
Aves PRDX4 35
  • 81.6 (n)
  • 91.86 (a)
PRDX4 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX4 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14602 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx4 35
  • 81.13 (n)
  • 93.61 (a)
Str.7399 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12199 35
zebrafish
(Danio rerio)
Actinopterygii prdx4 35
  • 74.81 (n)
  • 88.69 (a)
prdx4 36
  • 79 (a)
OneToOne
wufb59c09 35
African malaria mosquito
(Anopheles gambiae)
Insecta TPX3 35
  • 65.9 (n)
  • 74.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jafrac2 35
  • 64.36 (n)
  • 70.97 (a)
Jafrac2 36
  • 66 (a)
OneToOne
CG6888 37
  • 56 (a)
Prx5037 37
  • 60 (a)
Jafrac2 37
  • 69 (a)
Jafrac1 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea R07E5.2 37
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 36
  • 55 (a)
ManyToMany
TSA2 36
  • 53 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10388 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
OneToOne
Species with no ortholog for PRDX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX4 Gene

ENSEMBL:
Gene Tree for PRDX4 (if available)
TreeFam:
Gene Tree for PRDX4 (if available)

Paralogs for PRDX4 Gene

Paralogs for PRDX4 Gene

Selected SIMAP similar genes for PRDX4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for PRDX4 Gene

genes like me logo Genes that share paralogs with PRDX4: view

Variants for PRDX4 Gene

Sequence variations from dbSNP and Humsavar for PRDX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs12711 -- 23,667,574(+) TCATG(G/T)AGGCG reference, stop-gained, intron-variant
rs473769 -- 23,681,101(-) gcacc(A/C)gccac intron-variant
rs475171 -- 23,667,305(-) CAAGG(C/T)CTCCT upstream-variant-2KB, intron-variant
rs476316 -- 23,664,859(-) AAAAT(C/T)TCCCC intron-variant
rs477204 -- 23,671,305(-) ATATT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX4 Gene

Variant ID Type Subtype PubMed ID
nsv526897 CNV Gain 19592680

Relevant External Links for PRDX4 Gene

HapMap Linkage Disequilibrium report
PRDX4
Human Gene Mutation Database (HGMD)
PRDX4
Locus Specific Mutation Databases (LSDB)
PRDX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX4 Gene

Disorders for PRDX4 Gene

(1) MalaCards Diseases for PRDX4 Gene

Search for PRDX4 Gene in MalaCards »

(9) Novoseek inferred disease relationships for PRDX4 Gene

Disease -log(P) Hits PubMed IDs
shock 14.1 4
cancer 13.3 3
glioblastoma 11 1
leukemia 0 1
inflammation 0 1

Relevant External Links for PRDX4

Genetic Association Database (GAD)
PRDX4
Human Genome Epidemiology (HuGE) Navigator
PRDX4
genes like me logo Genes that share disorders with PRDX4: view

No data available for UniProtKB/Swiss-Prot for PRDX4 Gene

Publications for PRDX4 Gene

  1. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PMID: 9388242) Jin D.-Y. … Jeang K.-T. (J. Biol. Chem. 1997) 2 3 4 23
  2. Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (PMID: 15952740) Ahmed M. … Bergsten P. (J. Proteome Res. 2005) 3 23
  3. Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. (PMID: 18052930) Tavender T.J. … Bulleid N.J. (Biochem. J. 2008) 3 23
  4. Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. (PMID: 18272409) Lee S.U. … Kim S.H. (Cell Biol. Int. 2008) 3 23
  5. SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance. (PMID: 20157331) Edvardsen H. … Kristensen V.N. (Pharmacogenomics J. 2010) 3 48

Products for PRDX4 Gene

Sources for PRDX4 Gene

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