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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRDX4 Gene

protein-coding   GIFtS: 68
GCID: GC0XP023592

Peroxiredoxin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peroxiredoxin 41 2     EC 1.11.1.153 8
Antioxidant Enzyme AOE3722 3     PRX-42
Peroxiredoxin IV2 3     peroxiredoxin-42
Thioredoxin Peroxidase AO3722 3     prx-IV2
Thioredoxin-Dependent Peroxide Reductase A03722 3     Thioredoxin Peroxidase (Antioxidant Enzyme)2
AOE37-22 3     Prx-IV3

External Ids:    HGNC: 171691   Entrez Gene: 105492   Ensembl: ENSG000001231317   OMIM: 6065065   UniProtKB: Q131623   

Export aliases for PRDX4 gene to outside databases

Previous GC identifers: GC0XP022492 GC0XP022256 GC0XP022884 GC0XP023047 GC0XP023445 GC0XP021425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDX4 Gene:
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is
localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl
hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor
molecules. This protein has been found to play a regulatory role in the activation of the transcription factor
NF-kappaB. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRDX4 Gene: 
PRDX4 (peroxiredoxin 4) is a protein-coding gene. Diseases associated with PRDX4 include filariasis, and cystic echinococcosis, and among its related super-pathways are Synthesis of Prostaglandins (PG) and Thromboxanes (TX). GO annotations related to this gene include protein binding and thioredoxin peroxidase activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol
by a modulation of I-kappa-B-alpha phosphorylation

Gene Wiki entry for PRDX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDX4 gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   Meis-1b   MEF-2A   c-Jun   aMEF-2   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRDX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

PRDX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP023592:  view genomic region     (about GC identifiers)

Start:
23,682,379 bp from pter      End:
23,704,516 bp from pter
Size:
22,138 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162 (See protein sequence)
Recommended Name: Peroxiredoxin-4 precursor  
Size: 271 amino acids; 30540 Da
Subunit: Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (By similarity)
Subcellular location: Cytoplasm. Secreted
Miscellaneous: The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with
Cys-245-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The
enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Irreversibly inactivated by overoxidation of Cys-124 (to Cys-SO(3)H) upon oxidative stress
6/10 PDB 3D structures from and Proteopedia for PRDX4 (see all 10):
2PN8 (3D)        3TJB (3D)        3TJF (3D)        3TJG (3D)        3TJJ (3D)        3TJK (3D)    
Secondary accessions: Q6FHT3

Explore the universe of human proteins at neXtProt for PRDX4: NX_Q13162

Explore proteomics data for PRDX4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13162

  • 4/10 DME Specific Peptides for PRDX4 (Q13162) (see all 10)
     VGRSVDE  DFTFVCP  HGEVCPA  NDLPVGR 

    PRDX4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRDX4 Protein Expression
    REFSEQ proteins: NP_006397.1  
    ENSEMBL proteins: 
     ENSP00000368654   ENSP00000368646   ENSP00000368635   ENSP00000413736  

    Human Recombinant Protein Products for PRDX4: 
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    Novus Biologicals PRDX4 Proteins
    Novus Biologicals PRDX4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PRDX4
    Cloud-Clone Corp. Proteins for PRDX4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--

    PRDX4 for ontologies           About GeneDecksing



    PRDX4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX4
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    Abcam antibodies for PRDX4
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    ThermoFisher Antibody for PRDX4
    LSBio Antibodies in human, mouse, rat for PRDX4 

    Assay Products for PRDX4: 
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    Cloud-Clone Corp. ELISAs for PRDX4 
    Cloud-Clone Corp. CLIAs for PRDX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry Q13162

    ProtoNet protein and cluster: Q13162

    1 Blocks protein domain: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
    Similarity: Belongs to the AhpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    PRDX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX4_HUMAN, Q13162
    Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol
    by a modulation of I-kappa-B-alpha phosphorylation
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

         Enzyme Number (IUBMB): EC 1.11.1.151 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17644091
    GO:0008379thioredoxin peroxidase activity TAS9388242
    GO:0016209antioxidant activity ----
    GO:0016491oxidoreductase activity ----
    GO:0051920peroxiredoxin activity ----
         
    PRDX4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Prdx4):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    PRDX4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prdx4tm1.1Jufu for PRDX4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRDX4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRDX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX4 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRDX4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    2Selenium Pathway
    Selenium Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PRDX4
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for PRDX4
        Prostaglandin 2 biosynthesis and metabolism FM

    1 BioSystems Pathway for PRDX4
        Selenium Pathway




    PRDX4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/321 Interacting proteins for PRDX4 (Q131621, 2, 3 ENSP000003686464) via UniProtKB, MINT, STRING, and/or I2D (see all 321)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P4HBP072372, 3, ENSP000003278014MINT-8091005 MINT-8091054 I2D: score=1 STRING: ENSP00000327801
    DUSP23Q9BVJ72, 3MINT-8254721 I2D: score=2 
    HDAC6Q9UBN72, 3MINT-8258098 I2D: score=2 
    MAP4K2Q128512, 3MINT-8260449 I2D: score=2 
    ATP5BP065762, 3MINT-8079030 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007252I-kappaB phosphorylation TAS9388242
    GO:0055114oxidation-reduction process ----
    GO:0072593reactive oxygen species metabolic process IEA--

    PRDX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRDX4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDX4

    1 HMDB Compound for PRDX4    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    10/15 Novoseek inferred chemical compound relationships for PRDX4 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 57.6 15 9388242 (2), 18052930 (2), 12861054 (1), 15818395 (1) (see all 10)
    cysteine 50.6 3 19526557 (1), 11764930 (1), 17434115 (1)
    glyceraldehyde 3-phosphate 45.5 4 12622818 (1), 16431015 (1), 16947118 (1), 20450584 (1)
    oxygen 40.3 5 11229364 (2), 17210455 (1), 14648077 (1), 10731722 (1)
    nadph 37.7 2 18461048 (1), 20306272 (1)
    tert-butylhydroperoxide 32.2 1 15347790 (1)
    malate 21.3 2 16431015 (1), 16947118 (1)
    gdp 19.7 1 11981867 (1)
    serine 18.4 3 18838535 (1)
    superoxide 17.9 6 18461048 (1), 20306272 (1), 14648077 (1), 16431015 (1) (see all 5)

    1 PharmGKB related drug/compound annotation for PRDX4 gene    About this table
    Drug/compound PharmGKB Annotation
    docetaxelCA  

    Search CenterWatch for drugs/clinical trials and news about PRDX4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRDX4 gene: 
    NM_006406.1  

    Unigene Cluster for PRDX4:

    Peroxiredoxin 4
    Hs.83383  [show with all ESTs]
    Unigene Representative Sequence: CD579519
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379349 ENST00000379341(uc004dam.3) ENST00000495599 ENST00000379331
    ENST00000439422
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDX4

    Additional mRNA sequence: 

    BC003609.2 BC007107.1 BC016770.1 CR541668.1 CR541705.1 U25182.1 

    11 DOTS entries:

    DT.100797810  DT.86841214  DT.91769555  DT.97763798  DT.418270  DT.91769554  DT.100043017  DT.91916914 
    DT.92407979  DT.91989407  DT.97790799 

    24/356 AceView cDNA sequences (see all 356):

    CD105702 H91993 AI133226 BM450964 BG260175 AA927975 AI024994 AA588791 
    AA459663 AU077207 AA693955 AI077902 BQ181376 BG396972 U25182 BC003609 
    W67518 BM713987 AA160189 BG285084 BM835065 BQ706659 BC007107 AA731884 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
    SP1:                                      -                 -                                 
    SP2:                                -     -                 -                                 
    SP3:                                                        -                                 
    SP4:        -     -     -     -     -     -                 -                                 
    SP5:                                      -                                                   


    ECgene alternative splicing isoforms for PRDX4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRDX4 expression in normal human tissues (normalized intensities)      PRDX4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGTTGAT
    PRDX4 Expression
    About this image


    PRDX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)
             Mature Rod Bipolar Cells Inner Nuclear Layer
     
     Pancreas (Endocrine System)
     
     Kidney (Urinary System)

    See PRDX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRDX4

    SOURCE GeneReport for Unigene cluster: Hs.83383
        SABiosciences Expression via Pathway-Focused PCR Array including PRDX4: 
              Oxidative Stress in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PRDX4 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx41 , 5 peroxiredoxin 41, 5 86.97(n)1
    90.6(a)1
      X (72.38 cM)5
    533811  NM_016764.41  NP_058044.11 
     1553239185 
    chicken
    (Gallus gallus)
    Aves PRDX41 peroxiredoxin 4 78.43(n)
    86.27(a)
      418601  XM_416800.3  XP_416800.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX46
    Uncharacterized protein
    76(a)
    1 ↔ 1
    3(125627283-125643103)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146022 Xenopus laevis transcribed sequence with strong similarity more 81.75(n)    BX844818.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb59c092 wufb59c09 79.74(n)   322377  CK399401.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jafrac21 , 3 antioxidant3
    thioredoxin peroxidase 21
    69(a)
    (best of 4)3
    62.75(n)1
    67.65(a)1
      63A33
    535771  NM_080263.31  NP_525002.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TSA16
    TSA26
    Thioredoxin peroxidase, acts as both a ribosome-as...
    Stress inducible cytoplasmic thioredoxin peroxidas...
    54(a)
    52(a)
    many ↔ many
    many ↔ many
    XIII(220138-220728)
    IV(1365072-1365662)


    ENSEMBL Gene Tree for PRDX4 (if available)
    TreeFam Gene Tree for PRDX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRDX4 gene
    PRDX32  PRDX12  PRDX22  
    3 SIMAP similar genes for PRDX4 using alignment to 4 protein entries:     PRDX4_HUMAN (see all proteins):
    PRDX3    PRDX2    PRDX1

    PRDX4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRDX4
    PGOHUM00000245509 PGOHUM00000260055


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/409 SNPs in PRDX4 are shown (see all 409)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26653671,2
    C,H--23598025(-) AAAAAT/ATTTTT 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs732092571,2
    C--23598079(+) GGGCAT/CCCTGG 1 -- us2k12Minor allele frequency- C:0.00NA 3
    rs110949371,2
    C,A,H--23598211(+) GAATTG/ACTTGA 1 -- us2k16Minor allele frequency- A:0.11NA WA CSA 9
    rs21091421,2
    C--23598278(-) CTCGCC/TCTGTC 1 -- us2k13Minor allele frequency- T:0.00NA 5
    rs1880911741,2
    --23598412(+) TTTCAG/TGTTAG 1 -- us2k10--------
    rs25326251,2
    C,F,A,H--23598569(-) AAACTA/GACCTT 1 -- us2k118Minor allele frequency- G:0.13NS EA NA WA CSA 1985
    rs752025751,2
    C--23598577(+) TTTCCC/TTTTGA 1 -- us2k10--------
    rs1919272781,2
    --23598596(+) GGGTGC/GCGTGG 1 -- us2k10--------
    rs1841475201,2
    --23598660(+) GGCGGA/CGAGGG 1 -- us2k10--------
    rs37952201,2
    C,F,A,H--23598685(+) ATGGTA/GGGAAG 1 -- us2k118Minor allele frequency- G:0.62NS EA NA 1975

    HapMap Linkage Disequilibrium report for PRDX4 (23682379 - 23704516 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRDX4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526897CNV Gain19592680


    Human Gene Mutation Database (HGMD): PRDX4

    Locus Specific Mutation Databases (LSDB): PRDX4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDX4
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606506    OMIM disorders: --

    20/43 diseases for PRDX4 (see all 43):    About MalaCards
    filariasis    cystic echinococcosis    echinococcosis    central nervous system lymphoma
    brain cancer    stomach cancer    dengue hemorrhagic fever    cryptorchidism
    pancreatic ductal adenocarcinoma    acute promyelocytic leukemia    alcoholism    hemorrhagic fever
    epididymitis    celiac disease    vascular disease    fanconi's anemia
    choroiditis    ulcerative colitis    down syndrome    hepatocellular carcinoma


    PRDX4 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for PRDX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 14.1 5 12748950 (1), 15952740 (1), 18306929 (1), 18068167 (1)
    cancer 13.3 3 18272409 (1), 18220333 (1), 18366394 (1)
    glioblastoma 11 1 17233837 (1)
    leukemia 0 1 17656256 (1)
    inflammation 0 1 16720350 (1)
    breast cancer 0 1 18272409 (1)
    hepatocellular carcinoma 0 1 17552011 (1)
    adenocarcinoma 0 1 15239128 (1)
    tumors 0 1 15239128 (1)

    Genetic Association Database (GAD): PRDX4
    Human Genome Epidemiology (HuGE) Navigator: PRDX4 (4 documents)

    Export disorders for PRDX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRDX4 gene, integrated from 9 sources (see all 151):
    (articles sorted by number of sources associating them with PRDX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PubMed id 9388242)1, 2, 3, 9 Jin D.-Y.... Jeang K.-T. (1997)
    2. SNPs in genes coding for ROS metabolism and signallin g in association with docetaxel clearance. (PubMed id 20157331)1, 4 Edvardsen H....Kristensen V.N. (2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. (PubMed id 12059788)1, 2 Wagner E.... Rabilloud T. (2002)
    7. TNF-related apoptosis-inducing ligand suppresses PRDX4 expression. (PubMed id 19364504)1, 9 Wang H.Q....Zhang H.Y. (2009)
    8. Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. (PubMed id 18052930)1, 9 Tavender T.J....Bulleid N.J. (2008)
    9. Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. (PubMed id 18272409)1, 9 Lee S.U....Kim S.H. (2008)
    10. Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15952740)1, 9 Ahmed M....Bergsten P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10549 HGNC: 17169 AceView: PRDX4 Ensembl:ENSG00000123131 euGenes: HUgn10549
    ECgene: PRDX4 H-InvDB: PRDX4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRDX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRDX4 gene:
    Search GeneIP for patents involving PRDX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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