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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRDX4 Gene

protein-coding   GIFtS: 64
GCID: GC0XP023592

peroxiredoxin 4
 Explore 46 diseases affiliated with
PRDX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRDX4    

Aliases
for PRDX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Peroxiredoxin 41 2     EC 1.11.1.153 8
AOE37-21 2 3     PRX-42
Antioxidant Enzyme AOE3722 3     Peroxiredoxin-41
Peroxiredoxin IV2 3     Prx-IV3
Thioredoxin Peroxidase AO3722 3     Thioredoxin Peroxidase (Antioxidant Enzyme)2
Thioredoxin-Dependent Peroxide Reductase A03722 3     Prx-IV3

External Ids:    HGNC: 171691   Entrez Gene: 105492   Ensembl: ENSG000001231317   OMIM: 6065065   UniProtKB: Q131623   

Export aliases for PRDX4 gene to outside databases

Previous GC identifers: GC0XP022492 GC0XP022256 GC0XP022884 GC0XP023047 GC0XP023445 GC0XP021425


Summaries
for PRDX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRDX4:
The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is
localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides
to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein
has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a
modulation of I-kappa-B-alpha phosphorylation

Gene Wiki entry for PRDX4


Genomic Views
for PRDX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDX4 gene promoter:
         HOXA9B   HOXA9   AP-1   ATF-2   Meis-1b   MEF-2A   c-Jun   aMEF-2   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRDX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRDX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.11   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.11

PRDX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP023592:  view genomic region     (about GC identifiers)

Start:
 23,682,379 bp from pter      End:
 23,704,516 bp from pter
Size:
 22,138 bases      Orientation:
 plus strand

Proteins
for PRDX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162 (See protein sequence)
Recommended Name: Peroxiredoxin-4 precursor  
Size: 271 amino acids; 30540 Da
Subunit: Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation (By similarity)
Subcellular location: Cytoplasm. Secreted
Miscellaneous: The active site is the redox-active Cys-124 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-245-SH
of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be
subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Irreversibly inactivated by overoxidation of Cys-124 (to Cys-SO(3)H) upon oxidative stress
6/10 PDB 3D structures from and Proteopedia for PRDX4 (see all 10):
2PN8 (3D)        3TJB (3D)        3TJF (3D)        3TJG (3D)        3TJJ (3D)        3TJK (3D)    
Secondary accessions: Q6FHT3

Explore the universe of human proteins at neXtProt for PRDX4: NX_Q13162

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13162

    • 4/10 DME Specific Peptides for PRDX4 (Q13162) (see all 10)
     VGRSVDE  DFTFVCP  HGEVCPA  NDLPVGR 

    PRDX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006397.1  
    ENSEMBL proteins: 
     ENSP00000368654   ENSP00000368646   ENSP00000368635   ENSP00000413736  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: PRDX4
    OriGene Protein Over-expression Lysate: PRDX4
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    Novus Biologicals PRDX4 Proteins
    Novus Biologicals PRDX4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for PRDX4
    Uscn Proteins for PRDX4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005739mitochondrion IEA--


    PRDX4 for ontologies           About GeneDecksing



    PRDX4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX4
    R&D Systems Antibodies for PRDX4 (Peroxiredoxin 4)
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    Novus Biologicals PRDX4 Antibodies
    Search for Antibodies for PRDX4 at Abcam  
    Uscn Antibodies for PRDX4
    ThermoFisher Antibody for PRDX4

    Assay Products for PRDX4: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDX4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRDX4

    Protein Domains /
    Families
    for PRDX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRDX4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry Q13162

    ProtoNet protein and cluster: Q13162

    1 Blocks protein family: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
    Similarity: Belongs to the AhpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    Function
    for PRDX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PRDX4_HUMAN, Q13162
    Function: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a
    modulation of I-kappa-B-alpha phosphorylation
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

    Enzyme Number (IUBMB): EC 1.11.1.151 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX4
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRDX4 (see all 7)
    OriGene shRNA RFP: PRDX4
    OriGene siRNA: PRDX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRDX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRDX4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX4 (see all 3)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PRDX4
    Search LifeMap BioReagents cell lines for PRDX4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX4

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008379thioredoxin peroxidase activity TAS9388242
    GO:0016209antioxidant activity ----
    GO:0016491oxidoreductase activity ----


    PRDX4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Prdx4tm1.1Jufu for PRDX4
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Prdx4):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    PRDX4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRDX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    2Selenium Pathway
    		Selenium Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PRDX4
        Prostaglandin 2 biosynthesis and metabolism FM


    1 GeneGo (Thomson Reuters) Pathway for PRDX4
        Prostaglandin 2 biosynthesis and metabolism FM

    1 BioSystems Pathway for PRDX4 
        Selenium Pathway



    PRDX4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/307 Interacting proteins for PRDX4 (Q131621, 2, 3 ENSP000003686464) via UniProtKB, MINT, STRING, and/or I2D (see all 307)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P4HBP072372, 3, ENSP000003278014MINT-8091005 MINT-8091054 I2D: score=1 STRING: ENSP00000327801
    PDIA6Q150842, 3, ENSP000002722274MINT-8091076 MINT-8091095 I2D: score=1 STRING: ENSP00000272227
    DUSP23Q9BVJ72, 3MINT-8254721 I2D: score=2 
    HDAC6Q9UBN72, 3MINT-8258098 I2D: score=2 
    MAP4K2Q128512, 3MINT-8260449 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007252I-kappaB phosphorylation TAS9388242
    GO:0072593reactive oxygen species metabolic process IEA--


    PRDX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRDX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRDX4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDX4

    1 HMDB Compound for PRDX4    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    10/15 Novoseek chemical compound relationships for PRDX4 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    h2o2 57.6 15 9388242 (2), 18052930 (2), 12861054 (1), 15818395 (1) (see all 10)
    cysteine 50.6 3 19526557 (1), 11764930 (1), 17434115 (1)
    glyceraldehyde 3-phosphate 45.5 4 12622818 (1), 16431015 (1), 16947118 (1), 20450584 (1)
    oxygen 40.3 5 11229364 (2), 17210455 (1), 14648077 (1), 10731722 (1)
    nadph 37.7 2 18461048 (1), 20306272 (1)
    tert-butylhydroperoxide 32.2 1 15347790 (1)
    malate 21.3 2 16431015 (1), 16947118 (1)
    gdp 19.7 1 11981867 (1)
    serine 18.4 3 18838535 (1)
    superoxide 17.9 6 18461048 (1), 20306272 (1), 14648077 (1), 16431015 (1) (see all 5)

    1 PharmGKB related drug/compound annotation for PRDX4 gene
    Drug/compound PharmGKB Annotation
    docetaxelCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about PRDX4 

    Transcripts
    for PRDX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRDX4 gene: 
    NM_006406.1  

    Unigene Cluster for PRDX4:

    Peroxiredoxin 4
    Hs.83383  [show with all ESTs]
    Unigene Representative Sequence: CD579519
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379349 ENST00000379341(uc004dam.3) ENST00000495599 ENST00000379331
    ENST00000439422

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX4
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRDX4 (see all 7)
    OriGene shRNA RFP: PRDX4
    OriGene siRNA: PRDX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRDX4
    Clone
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    GenScript: all cDNA clones in your preferred vector: PRDX4 (NM_006406)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX4 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDX4

    Additional cDNA sequence: 

    BC003609.2 BC007107.1 BC016770.1 CR541668.1 CR541705.1 U25182.1 

    11 DOTS entries:

    DT.100797810  DT.86841214  DT.91769555  DT.97763798  DT.418270  DT.91769554  DT.100043017  DT.91916914 
    DT.92407979  DT.91989407  DT.97790799 

    24/356 AceView cDNA sequences (see all 356):

    CB110732 AA548182 BF222310 CD105702 BE876223 BP870647 AL699413 BP870903 
    AI024994 CA418700 BC007107 AA731884 CA425779 AU077207 W67518 AW134881 
    BQ182908 AI221075 AA468841 H91993 BM818431 AI133226 BM835065 BP871004 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX4    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
    SP1:                                      -                 -                                 
    SP2:                                -     -                 -                                 
    SP3:                                                        -                                 
    SP4:        -     -     -     -     -     -                 -                                 
    SP5:                                      -                                                   


    ECgene alternative splicing isoforms for PRDX4

    Expression
    for PRDX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRDX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCTGTTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRDX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRDX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRDX4

    SOURCE GeneReport for Unigene cluster: Hs.83383
        SABiosciences Expression via Pathway-Focused PCR Array including PRDX4: 
              Oxidative Stress in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX4

    Orthologs
    for PRDX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for PRDX4 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRDX41 peroxiredoxin 4 78.43(n)
    86.27(a)    		   418601  XM_416800.3  XP_416800.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PRDX46
    		 --
    		 74(a)
    		 1 ↔ 1
    		 3(125627610-125641275)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.146022 Xenopus laevis transcribed sequence with strong similarity more 81.75(n)    BX844818.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb59c092 wufb59c09 79.74(n)   322377  CK399401.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Jafrac21 , 3 antioxidant3
    thioredoxin peroxidase 21    		 69(a)
    (best of 4)3
    62.75(n)1
    67.65(a)1    		   63A33
    535771  NM_080263.31  NP_525002.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea R07E5.23 Mer5 (mouse) 57(a)   III(4479241-4480145)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G116306
    2-Cys Prx B6
    		 2-Cys peroxiredoxin BAS1-like protein
    		 42(a)
    40(a)
    		 possible ortholog
    possible ortholog
    		 3(3672120-3674075)
    5(1919213-1921425)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 peroxiredoxin, putative, expressed
    		 55(a)
    43(a)
    		 possible ortholog
    possible ortholog
    		 4(20388010-20392951)
    2(19876184-19880477)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ahpC6
    		 alkyl hydroperoxide reductase, C22 subunit
    		 34(a)
    		 possible ortholog
    		 Chromosome(638168-638731)


    ENSEMBL Gene Tree for PRDX4 (if available)
    TreeFam Gene Tree for PRDX4 (if available) 

    Paralogs
    for PRDX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRDX4 gene
    PRDX32  PRDX12  PRDX22  
    3 SIMAP similar genes for PRDX4 using alignment to 4 protein entries:     PRDX4_HUMAN (see all proteins):
    PRDX3    PRDX2    PRDX1

    PRDX4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for PRDX4
    PGOHUM00000245509 PGOHUM00000260055


    Genomic Variants
    for PRDX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/340 NCBI SNPs in PRDX4 are shown (see all 340)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs26653671,2
    		C,H,--23683668(-) AAAAAT/ATTTTT 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs732092571,2
    		C,--23683722(+) GGGCAT/CCCTGG 1 -- us2k12Minor allele frequency- C:0.00NA 3
    rs110949371,2
    		C,A,H,--23683854(+) GAATTG/ACTTGA 1 -- us2k16Minor allele frequency- A:0.11NA WA CSA 9
    rs21091421,2
    		C,--23683921(-) CTCGCC/TCTGTC 1 -- us2k13Minor allele frequency- T:0.00NA 5
    rs770394001,2
    		C--23683959(+) AAAAAA/CAACCT 1 -- us2k13Minor allele frequency- C:0.00NA CSA 3
    rs1880911741,2
    		--23684055(+) TTTCAG/TGTTAG 1 -- us2k10--------
    rs30635791,2
    		C,--23684182(-) CTCGC-/TCGC  
                GTTTT     		1 -- us2k10--------
    rs2011720341,2
    		C--23684182(-) CTCGCG/TTTTTA 1 -- us2k10--------
    rs38389511,2
    		C--23684188(+) CGAGC-/GAGC  
                TATTC     		1 -- us2k10--------
    rs25326251,2
    		C,F,A,H,--23684208(-) AAACTA/GACCTT 1 -- us2k118Minor allele frequency- G:0.13NS EA NA WA CSA 1985

    HapMap Linkage Disequilibrium report for PRDX4 (23682379 - 23704516 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PRDX4: --
    Locus Specific Mutation Databases (LSDB): PRDX4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRDX4
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDX4

    Disorders / Diseases
    for PRDX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRDX4 for disorders           About GeneDecksing

    OMIM gene information: 606506    OMIM disorders: --

    20/46 diseases for PRDX4 (see all 46):    About MalaCards
    central nervous system lymphoma    dengue hemorrhagic fever    hemorrhagic fever    cystic echinococcosis
    echinococcosis    systemic lupus erythematosus    acute promyelocytic leukemia    lupus erythematosus
    pancreatic ductal adenocarcinoma    acute myeloid leukemia    fanconi's anemia    alcoholism
    myeloid leukemia    ulcerative colitis    filariasis    cryptorchidism
    stomach cancer    celiac disease    hepatocellular carcinoma    down syndrome

    9 Novoseek disease relationships for PRDX4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 14.1 5 12748950 (1), 15952740 (1), 18306929 (1), 18068167 (1)
    cancer 13.3 3 18272409 (1), 18220333 (1), 18366394 (1)
    glioblastoma 11 1 17233837 (1)
    leukemia 0 1 17656256 (1)
    inflammation 0 1 16720350 (1)
    breast cancer 0 1 18272409 (1)
    hepatocellular carcinoma 0 1 17552011 (1)
    adenocarcinoma 0 1 15239128 (1)
    tumors 0 1 15239128 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRDX4 (4 documents)

    Export disorders for PRDX4 gene to outside databases

    Publications
    for PRDX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRDX4 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with PRDX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PubMed id 9388242)1, 2, 3, 9 Jin D.-Y.... Jeang K.-T. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. (PubMed id 12059788)1, 2 Wagner E.... Rabilloud T. (2002)
    4. TNF-related apoptosis-inducing ligand suppresses PRDX4 expression. (PubMed id 19364504)1, 9 Wang H.Q....Zhang H.Y. (2009)
    5. Peroxiredoxin IV is an endoplasmic reticulum-localized enzyme forming oligomeric complexes in human cells. (PubMed id 18052930)1, 9 Tavender T.J....Bulleid N.J. (2008)
    6. Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. (PubMed id 18272409)1, 9 Lee S.U....Kim S.H. (2008)
    7. Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. (PubMed id 15952740)1, 9 Ahmed M....Bergsten P. (2005)
    8. Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4. (PubMed id 21916849)1 Wang X....Wang C.C. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Peroxiredoxins 3 and 4 are overexpressed in prostate c ancer tissue and affect the proliferation of prostate cancer cells in vitro. (PubMed id 22424448)1 Ummanni R....Balabanov S. (2012)

    External Searches for PRDX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRDX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10549 HGNC: 17169 AceView: PRDX4 Ensembl:ENSG00000123131 euGenes: HUgn10549
    ECgene: PRDX4 H-InvDB: PRDX4

    Other Databases showing PRDX4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRDX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRDX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PRDX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRDX4 gene:
    Search GeneIP for patents involving PRDX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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