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Aliases for PRDX3 Gene

Aliases for PRDX3 Gene

  • Peroxiredoxin 3 2 3 5
  • Antioxidant Protein 1 2 3 4
  • Protein MER5 Homolog 3 4
  • Peroxiredoxin III 3 4
  • EC 1.11.1.15 4 61
  • Prx-III 3 4
  • HBC189 3 4
  • AOP-1 3 4
  • AOP1 3 4
  • Thioredoxin-Dependent Peroxide Reductase, Mitochondrial 3
  • Peroxiredoxin-3 4
  • PRO1748 3
  • SP-22 3
  • MER5 3

External Ids for PRDX3 Gene

Previous HGNC Symbols for PRDX3 Gene

  • AOP1

Previous GeneCards Identifiers for PRDX3 Gene

  • GC10M119845
  • GC10M120170
  • GC10M121058
  • GC10M120591
  • GC10M120917
  • GC10M114556
  • GC10M120928

Summaries for PRDX3 Gene

Entrez Gene Summary for PRDX3 Gene

  • This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]

GeneCards Summary for PRDX3 Gene

PRDX3 (Peroxiredoxin 3) is a Protein Coding gene. Diseases associated with PRDX3 include Fuchs' Endothelial Dystrophy. Among its related pathways are Cellular Senescence and Folate Metabolism. GO annotations related to this gene include identical protein binding and oxidoreductase activity. An important paralog of this gene is PRDX4.

UniProtKB/Swiss-Prot for PRDX3 Gene

  • Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.

Gene Wiki entry for PRDX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX3 Gene

Genomics for PRDX3 Gene

Regulatory Elements for PRDX3 Gene

Enhancers for PRDX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F119205 1.4 FANTOM5 ENCODE 6.8 -31.0 -31032 8.3 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF263 SP5 SFXN4 RPL17P36 SEC23IP PHACTR2P1 GRK5 PRDX3 EIF3A GRK5-IT1 RN7SL749P
GH10F119176 1.1 ENCODE 8.4 +1.0 1027 3.9 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF263 SFXN4 PRDX3
GH10F119197 1.1 Ensembl ENCODE 7.6 -19.9 -19857 2.2 SOX13 ELF3 CTCF TFAP4 SAP130 JUN ARID4B CEBPG RAD21 ZNF664 SFXN4 PRDX3 FAM45A GC10M119191 GRK5
GH10F119367 1.3 FANTOM5 Ensembl ENCODE 4.5 -193.3 -193310 8.7 CTCF KLF1 KLF17 ZIC2 RAD21 ZKSCAN1 ZFHX2 POLR2A SCRT2 EED GRK5 RGS10 PRDX3 MIR4681 LOC105378511
GH10F119175 0.8 ENCODE 0.8 +3.5 3482 0.2 SOX13 DRAP1 TBP HDGF SAP130 ARID4B CEBPG TEAD3 POLR2A ZNF600 PRDX3 SFXN4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRDX3 on UCSC Golden Path with GeneCards custom track

Promoters for PRDX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000117812 365 1801 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF263

Genomic Location for PRDX3 Gene

Chromosome:
10
Start:
119,167,699 bp from pter
End:
119,178,865 bp from pter
Size:
11,167 bases
Orientation:
Minus strand

Genomic View for PRDX3 Gene

Genes around PRDX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX3 Gene

Proteins for PRDX3 Gene

  • Protein details for PRDX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30048-PRDX3_HUMAN
    Recommended name:
    Thioredoxin-dependent peroxide reductase, mitochondrial
    Protein Accession:
    P30048
    Secondary Accessions:
    • B2R7Z0
    • D3DRC9
    • E9PH29
    • P35690
    • Q0D2H1
    • Q13776
    • Q5T5V2
    • Q96HK4

    Protein attributes for PRDX3 Gene

    Size:
    256 amino acids
    Molecular mass:
    27693 Da
    Quaternary structure:
    • Dodecameric ring assembled from homodimeric units; disulfide-linked, upon oxidation. The rings have an approximate diameter of 150 A and a central hole of 70 A. 3-5% of the rings are interlocked by pairs. Binds MAP3K13. Interacts with NEK6. Interacts with LRRK2.
    Miscellaneous:
    • Irreversibly inactivated by overoxidation of Cys-108 (to Cys-SO(3)H) upon oxidative stress.
    • The active site is the redox-active Cys-108 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-229-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX3 Gene

    Alternative splice isoforms for PRDX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX3 Gene

Selected DME Specific Peptides for PRDX3 Gene

P30048:
  • HGEVCPA
  • EVCPANW
  • NDLPVGR
  • SRDYGVL
  • RGLFIID
  • DFTFVCP
  • HLAWINTPR

Post-translational modifications for PRDX3 Gene

  • Phosphorylated by LRRK2; phosphorylation reduces perodixase activity.
  • Ubiquitination at Lys 149 and Lys 253
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRDX3 (Peroxiredoxin 3)
  • Cloud-Clone Corp. Antibodies for PRDX3

Domains & Families for PRDX3 Gene

Gene Families for PRDX3 Gene

Suggested Antigen Peptide Sequences for PRDX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30048

UniProtKB/Swiss-Prot:

PRDX3_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the AhpC/TSA family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the AhpC/TSA family.
genes like me logo Genes that share domains with PRDX3: view

Function for PRDX3 Gene

Molecular function for PRDX3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical-generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.

Enzyme Numbers (IUBMB) for PRDX3 Gene

Gene Ontology (GO) - Molecular Function for PRDX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0005515 protein binding IPI 15750338
GO:0008022 protein C-terminus binding IPI 17060495
GO:0008379 thioredoxin peroxidase activity IDA 21850687
GO:0008785 alkyl hydroperoxide reductase activity NAS 7733872
genes like me logo Genes that share ontologies with PRDX3: view
genes like me logo Genes that share phenotypes with PRDX3: view

Animal Models for PRDX3 Gene

MGI Knock Outs for PRDX3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX3 Gene

Localization for PRDX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX3 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 5
endosome 5
cytoskeleton 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRDX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18205602
GO:0005739 mitochondrion IEA,IDA 17893648
GO:0005759 mitochondrial matrix TAS --
GO:0005769 early endosome IDA 15750338
GO:0005829 cytosol IDA 21850687
genes like me logo Genes that share ontologies with PRDX3: view

Pathways & Interactions for PRDX3 Gene

genes like me logo Genes that share pathways with PRDX3: view

Pathways by source for PRDX3 Gene

1 GeneGo (Thomson Reuters) pathway for PRDX3 Gene

Gene Ontology (GO) - Biological Process for PRDX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001893 maternal placenta development IEA --
GO:0006915 apoptotic process IEA --
GO:0006979 response to oxidative stress IMP 18195003
GO:0007005 mitochondrion organization IMP 12011429
genes like me logo Genes that share ontologies with PRDX3: view

No data available for SIGNOR curated interactions for PRDX3 Gene

Drugs & Compounds for PRDX3 Gene

(4) Drugs for PRDX3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0

(3) Additional Compounds for PRDX3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX3: view

Transcripts for PRDX3 Gene

Unigene Clusters for PRDX3 Gene

Peroxiredoxin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2:
SP3: - - -
SP4:

Relevant External Links for PRDX3 Gene

GeneLoc Exon Structure for
PRDX3
ECgene alternative splicing isoforms for
PRDX3

Expression for PRDX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRDX3 Gene

Protein differential expression in normal tissues from HIPED for PRDX3 Gene

This gene is overexpressed in Liver, secretome (7.3) and Adrenal (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX3 Gene



Protein tissue co-expression partners for PRDX3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRDX3 Gene:

PRDX3

SOURCE GeneReport for Unigene cluster for PRDX3 Gene:

Hs.523302
genes like me logo Genes that share expression patterns with PRDX3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDX3 Gene

Orthologs for PRDX3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX3 34 35
  • 99.61 (n)
-- 35
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
PRDX3 34
  • 88.15 (n)
-- 35
  • 88 (a)
OneToMany
-- 35
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PRDX3 34 35
  • 88.8 (n)
mouse
(Mus musculus)
Mammalia Prdx3 34 16 35
  • 84.24 (n)
oppossum
(Monodelphis domestica)
Mammalia PRDX3 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx3 34
  • 83.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX3 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDX3 34 35
  • 71.73 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx3 34
  • 70.69 (n)
zebrafish
(Danio rerio)
Actinopterygii prdx3 34 35
  • 66.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta Jafrac1 36
  • 64 (a)
Prx5037 36
  • 63 (a)
Prx3 34 35
  • 61.74 (n)
CG6888 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TPX1 34
  • 58.6 (n)
worm
(Caenorhabditis elegans)
Secernentea R07E5.2 36
  • 66 (a)
prdx-3 34 35
  • 60.43 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER312W 34
  • 59.55 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 35
  • 59 (a)
ManyToMany
TSA2 34 35
  • 57.12 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01628g 34
  • 58.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4391 35
  • 66 (a)
OneToOne
Species where no ortholog for PRDX3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX3 Gene

ENSEMBL:
Gene Tree for PRDX3 (if available)
TreeFam:
Gene Tree for PRDX3 (if available)

Paralogs for PRDX3 Gene

Paralogs for PRDX3 Gene

(4) SIMAP similar genes for PRDX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRDX3: view

Variants for PRDX3 Gene

Sequence variations from dbSNP and Humsavar for PRDX3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10749295 -- 119,172,085(+) CATTT(C/T)ATCAG intron-variant
rs10749296 -- 119,174,840(+) ACACA(C/G)ACCCT intron-variant
rs10749297 -- 119,175,617(+) GTCTC(C/G)ATCTC intron-variant
rs10749298 -- 119,176,566(+) ATTTC(A/G)CTCAG intron-variant
rs10886407 -- 119,173,088(+) CGCCC(A/G)CCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX3 Gene

Variant ID Type Subtype PubMed ID
nsv1041093 CNV gain 25217958
nsv552214 CNV loss 21841781
nsv825583 CNV gain 20364138
nsv825584 CNV gain 20364138

Variation tolerance for PRDX3 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX3 Gene

Disorders for PRDX3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRDX3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
fuchs' endothelial dystrophy
  • fced
- elite association - COSMIC cancer census association via MalaCards
Search PRDX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX3

Genetic Association Database (GAD)
PRDX3
Human Genome Epidemiology (HuGE) Navigator
PRDX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX3
genes like me logo Genes that share disorders with PRDX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX3 Gene

Publications for PRDX3 Gene

  1. Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. (PMID: 7733872) Tsuji K. … Obinata M. (Biochem. J. 1995) 2 3 4 22 64
  2. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. (PMID: 21850687) Angeles D.C. … Tan E.K. (Hum. Mutat. 2011) 3 4 64
  3. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PMID: 20873783) Vaz Meirelles G. … Kobarg J. (J. Proteome Res. 2010) 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Silencing the Peroxiredoxin III gene inhibits cell proliferation in breast cancer. (PMID: 20043069) Chua P.J. … Bay B.H. (Int. J. Oncol. 2010) 3 22 64

Products for PRDX3 Gene

Sources for PRDX3 Gene

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