Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRDX2 Gene

Aliases for PRDX2 Gene

  • Peroxiredoxin 2 2 3 5
  • Thioredoxin-Dependent Peroxide Reductase 1 2 3 4
  • Thioredoxin Peroxidase 1 2 3 4
  • Natural Killer Cell-Enhancing Factor B 3 4
  • Thiol-Specific Antioxidant 1 2 3
  • EC 1.11.1.15 4 61
  • NKEF-B 3 4
  • Torin 2 3
  • TDPX1 3 4
  • NKEFB 3 4
  • PRP 3 4
  • TSA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 2a 3
  • Thiol-Specific Antioxidant Protein 4
  • Natural Killer-Enhancing Factor B 2
  • Peroxiredoxin-2 3
  • EC 1.11.1 61
  • HEL-S-2a 3
  • PRXII 3
  • TPX1 3
  • PTX1 3
  • PRX2 3

External Ids for PRDX2 Gene

Previous HGNC Symbols for PRDX2 Gene

  • TDPX1

Previous GeneCards Identifiers for PRDX2 Gene

  • GC19M013039
  • GC19M013130
  • GC19M012752
  • GC19M012768
  • GC19M012907
  • GC19M012479

Summaries for PRDX2 Gene

Entrez Gene Summary for PRDX2 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

GeneCards Summary for PRDX2 Gene

PRDX2 (Peroxiredoxin 2) is a Protein Coding gene. Diseases associated with PRDX2 include In Situ Carcinoma and Vaginal Cancer. Among its related pathways are Gene Expression and Neurodegenerative Diseases. GO annotations related to this gene include oxidoreductase activity and peroxiredoxin activity. An important paralog of this gene is PRDX1.

UniProtKB/Swiss-Prot for PRDX2 Gene

  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Gene Wiki entry for PRDX2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX2 Gene

Genomics for PRDX2 Gene

Regulatory Elements for PRDX2 Gene

Enhancers for PRDX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012765 1.2 ENCODE dbSUPER 19.3 +35.8 35784 1.0 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF121 SLC30A9 ZNF143 ZNF207 PRDX2 RNASEH2A MAST1 DNASE2 GC19M012762 GC19M012774 BEST2
GH19G012781 1.9 FANTOM5 ENCODE dbSUPER 9.2 +12.6 12613 16.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ZNF136 ZNF844 CCDC130 ZNF564 ZNF442 ZNF625 MRI1 ZNF44 C19orf43 WDR83OS
GH19G012825 1.2 Ensembl ENCODE 12.3 -23.9 -23912 1.4 PKNOX1 ATF1 ARID4B SLC30A9 ZNF121 GLIS2 ZNF143 SP3 SP5 REST PRDX2 BEST2 GCDH GC19M012828 LOC105372281
GH19G012828 1.1 Ensembl ENCODE 9.7 -26.8 -26791 0.6 ELF3 ARID4B NFXL1 ZNF48 ZBTB40 ZNF335 GLIS2 ZNF766 EGR1 ETV6 PRDX2 GC19M012828 MAST1
GH19G012763 0.7 dbSUPER 12.8 +38.6 38643 1.5 HDGF CTCF RFX1 ESRRA CBX3 AGO1 NR2F2 CBX1 EGR1 POLR2A JUNB HOOK2 PRDX2 ASNA1 C19orf43 TNPO2 MAST1 RNASEH2A DNASE2 GC19M012774
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRDX2 on UCSC Golden Path with GeneCards custom track

Promoters for PRDX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107311 210 1401 HDGF HNRNPUL1 PKNOX1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for PRDX2 Gene

Chromosome:
19
Start:
12,796,820 bp from pter
End:
12,801,910 bp from pter
Size:
5,091 bases
Orientation:
Minus strand

Genomic View for PRDX2 Gene

Genes around PRDX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX2 Gene

Proteins for PRDX2 Gene

  • Protein details for PRDX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32119-PRDX2_HUMAN
    Recommended name:
    Peroxiredoxin-2
    Protein Accession:
    P32119
    Secondary Accessions:
    • A8K0C0
    • P31945
    • P32118
    • P35701
    • Q6FHG4
    • Q92763
    • Q9UC23

    Protein attributes for PRDX2 Gene

    Size:
    198 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
    Miscellaneous:
    • Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.
    • The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-172-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX2 Gene

    Alternative splice isoforms for PRDX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX2 Gene

Selected DME Specific Peptides for PRDX2 Gene

P32119:
  • HGEVCPA
  • TAVVDGAFKE
  • EVLGVSVDS
  • LRLVQAFQ
  • VGRSVDE
  • LSDYKGK
  • EVCPAGWKPG
  • NDLPVGR
  • LRQITVND
  • SKEYFSK
  • RGLFIID
  • DFTFVCP
  • PGSDTIKP
  • HLAWINTPR

Post-translational modifications for PRDX2 Gene

  • Ubiquitination at Lys16, Lys26, Lys92, and Lys135
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRDX2 (Peroxiredoxin 2)

Domains & Families for PRDX2 Gene

Gene Families for PRDX2 Gene

Graphical View of Domain Structure for InterPro Entry

P32119

UniProtKB/Swiss-Prot:

PRDX2_HUMAN :
  • Belongs to the AhpC/TSA family.
Family:
  • Belongs to the AhpC/TSA family.
genes like me logo Genes that share domains with PRDX2: view

Function for PRDX2 Gene

Molecular function for PRDX2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Enzyme Numbers (IUBMB) for PRDX2 Gene

Gene Ontology (GO) - Molecular Function for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity IEA --
GO:0008379 thioredoxin peroxidase activity TAS,IDA 18606987
GO:0016209 antioxidant activity NAS 12943237
GO:0016491 oxidoreductase activity IEA --
GO:0051920 peroxiredoxin activity IEA --
genes like me logo Genes that share ontologies with PRDX2: view
genes like me logo Genes that share phenotypes with PRDX2: view

Animal Models for PRDX2 Gene

MGI Knock Outs for PRDX2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PRDX2

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX2 Gene

Localization for PRDX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDX2 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
cytoskeleton 2
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PRDX2: view

Pathways & Interactions for PRDX2 Gene

genes like me logo Genes that share pathways with PRDX2: view

Gene Ontology (GO) - Biological Process for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress NAS 11904290
GO:0019430 removal of superoxide radicals IDA 20978343
GO:0034599 cellular response to oxidative stress TAS,IDA --
GO:0042744 hydrogen peroxide catabolic process TAS 18606987
GO:0042981 regulation of apoptotic process IMP 12943237
genes like me logo Genes that share ontologies with PRDX2: view

No data available for SIGNOR curated interactions for PRDX2 Gene

Drugs & Compounds for PRDX2 Gene

(13) Drugs for PRDX2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
3-Sulfinoalanine Experimental Pharma Target 0
N-Carbamoyl-Alanine Experimental Pharma Target 0
calcium Nutra 0

(12) Additional Compounds for PRDX2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRDX2: view

Transcripts for PRDX2 Gene

Unigene Clusters for PRDX2 Gene

Peroxiredoxin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:

Relevant External Links for PRDX2 Gene

GeneLoc Exon Structure for
PRDX2
ECgene alternative splicing isoforms for
PRDX2

Expression for PRDX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRDX2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRDX2 Gene



Protein tissue co-expression partners for PRDX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDX2 Gene:

PRDX2

SOURCE GeneReport for Unigene cluster for PRDX2 Gene:

Hs.432121

Evidence on tissue expression from TISSUES for PRDX2 Gene

  • Blood(5)
  • Nervous system(5)
  • Lung(4.8)
  • Liver(4.6)
  • Skin(4.5)
  • Intestine(3.9)
  • Kidney(3.4)
  • Heart(3.1)
  • Eye(2.9)
  • Muscle(2.9)
  • Bone marrow(2.4)
  • Adrenal gland(2.3)
  • Thyroid gland(2.3)
  • Pancreas(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with PRDX2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDX2 Gene

Orthologs for PRDX2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX2 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia PRDX2 34 35
  • 88.22 (n)
mouse
(Mus musculus)
Mammalia Prdx2 34 16 35
  • 88.22 (n)
Gm5225 35
  • 72 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PRDX2 34 35
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Prdx2 34
  • 87.04 (n)
oppossum
(Monodelphis domestica)
Mammalia PRDX2 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX2 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX2 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx2 34
  • 72.43 (n)
zebrafish
(Danio rerio)
Actinopterygii prdx2 34 35
  • 72.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Jafrac1 36 34 35
  • 67.38 (n)
Jafrac2 36
  • 67 (a)
Prx5037 36
  • 62 (a)
CG6888 36 35
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TPX2 34
  • 65.97 (n)
worm
(Caenorhabditis elegans)
Secernentea F09E5.2 36
  • 70 (a)
prdx-2 34 35
  • 66.67 (n)
R07E5.2 36
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 34 35 37
  • 61.14 (n)
TSA2 35
  • 61 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11630 34
  • 61.35 (n)
rice
(Oryza sativa)
Liliopsida Os02g0537700 34
  • 61.52 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tpx1 34
  • 60.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 60 (a)
OneToMany
Species where no ortholog for PRDX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX2 Gene

ENSEMBL:
Gene Tree for PRDX2 (if available)
TreeFam:
Gene Tree for PRDX2 (if available)

Paralogs for PRDX2 Gene

Paralogs for PRDX2 Gene

(3) SIMAP similar genes for PRDX2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PRDX2 Gene

genes like me logo Genes that share paralogs with PRDX2: view

Variants for PRDX2 Gene

Sequence variations from dbSNP and Humsavar for PRDX2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000287165 -- 12,803,528(+) TAGTT(C/T)CTCTG intron-variant, upstream-variant-2KB
rs1000657412 -- 12,803,148(+) TACTC(A/T)AGAGG intron-variant, upstream-variant-2KB
rs1002013450 -- 12,798,628(+) TTACA(A/G)GTGTG intron-variant
rs1002440054 -- 12,798,604(+) CCTAG(A/G)CCTCC intron-variant
rs1002574924 -- 12,803,197(+) CTGCA(A/G)TGAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRDX2 Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for PRDX2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX2 Gene

Human Gene Mutation Database (HGMD)
PRDX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX2 Gene

Disorders for PRDX2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PRDX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
in situ carcinoma
  • carcinoma in situ
vaginal cancer
  • malignant neoplasm of vagina
fuchs' endothelial dystrophy
  • fced
hereditary spherocytosis
  • spherocytosis, type 1
- elite association - COSMIC cancer census association via MalaCards
Search PRDX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX2

Genetic Association Database (GAD)
PRDX2
Human Genome Epidemiology (HuGE) Navigator
PRDX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX2
genes like me logo Genes that share disorders with PRDX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX2 Gene

Publications for PRDX2 Gene

  1. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) SchlAowicke EngstrAPm K. … Broberg K. (Mutat. Res. 2009) 3 22 46 64
  2. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. (PMID: 7607688) Pahl P. … Patterson D. (Genomics 1995) 2 3 22 64
  3. The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. (PMID: 8144038) Lim Y.-S. … Kim I.-H. (Gene 1994) 3 4 22 64
  4. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. (PMID: 20363977) Besgen P. … Prinz J.C. (J. Immunol. 2010) 3 22 64
  5. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic. (PMID: 19896490) EngstrAPm K.S. … Broberg K. (Mutat. Res. 2010) 3 46 64

Products for PRDX2 Gene

Sources for PRDX2 Gene

Content
Loading form....