Aliases for PRDX2 Gene
External Ids for PRDX2 Gene
Previous Symbols for PRDX2 Gene
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
GeneCards Summary for PRDX2 Gene
PRDX2 (Peroxiredoxin 2) is a Protein Coding gene. Diseases associated with PRDX2 include fuchs' endothelial dystrophy and in situ carcinoma. Among its related pathways are Cellular Senescence and Selenium Pathway. GO annotations related to this gene include antioxidant activity and thioredoxin peroxidase activity. An important paralog of this gene is PRDX3.
UniProtKB/Swiss-Prot for PRDX2 Gene
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)