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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRDX2 Gene

protein-coding   GIFtS: 70
GCID: GC19M012907

Peroxiredoxin 2


(Previous symbol: TDPX1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peroxiredoxin 21 2     TSA2 3
TDPX11 2 3     EC 1.11.1.153 8
Thioredoxin Peroxidase 11 2 3     Natural Killer-Enhancing Factor B1
Thioredoxin-Dependent Peroxide Reductase 11 2 3     PRX22
Thiol-Specific Antioxidant 11 2     PRXII2
torin1 2     PTX12
Natural Killer Cell-Enhancing Factor B2 3     TPX12
NKEF-B2 3     peroxiredoxin-22
NKEFB2 3     Thiol-Specific Antioxidant Protein3
PRP2 3     EC 1.11.18

External Ids:    HGNC: 93531   Entrez Gene: 70012   Ensembl: ENSG000001678157   OMIM: 6005385   UniProtKB: P321193   

Export aliases for PRDX2 gene to outside databases

Previous GC identifers: GC19M013039 GC19M013130 GC19M012752 GC19M012768 GC19M012479


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDX2 Gene:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and
alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to
the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7
angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making
this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect
and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5,
6, 10 and 13. (provided by RefSeq, Mar 2013)

GeneCards Summary for PRDX2 Gene: 
PRDX2 (peroxiredoxin 2) is a protein-coding gene. Diseases associated with PRDX2 include fuchs' endothelial dystrophy, and in situ carcinoma, and among its related super-pathways are Synthesis of Prostaglandins (PG) and Thromboxanes (TX) and PKA activation. GO annotations related to this gene include thioredoxin peroxidase activity and antioxidant activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119
Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through
the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in
eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors
and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

Gene Wiki entry for PRDX2 (Peroxiredoxin 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDX2 gene promoter:
         STAT1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRDX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

PRDX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012907:  view genomic region     (about GC identifiers)

Start:
12,907,634 bp from pter      End:
12,912,694 bp from pter
Size:
5,061 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119 (See protein sequence)
Recommended Name: Peroxiredoxin-2  
Size: 198 amino acids; 21892 Da
Subunit: Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5
dimers, depending on pH and calcium concentration. Interacts with TIPIN
Subcellular location: Cytoplasm
Miscellaneous: The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with
Cys-172-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The
enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO(2)H and Cys-SO(3)H.
Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
1 PDB 3D structure from and Proteopedia for PRDX2:
1QMV (3D)    
Secondary accessions: A8K0C0 P31945 P32118 P35701 Q6FHG4 Q92763 Q9UC23
Alternative splicing: 2 isoforms:  P32119-1   P32119-2   (No experimental confirmation available. Due to intron retention. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for PRDX2: NX_P32119

Explore proteomics data for PRDX2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32119

  • 4/14 DME Specific Peptides for PRDX2 (P32119) (see all 14)
     LSDYKGK  VGRSVDE  DFTFVCP  HGEVCPA 

    PRDX2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRDX2 Protein Expression
    REFSEQ proteins: NP_005800.3  
    ENSEMBL proteins: 
     ENSP00000334063   ENSP00000301522   ENSP00000408905  

    Human Recombinant Protein Products for PRDX2: 
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    GenScript Custom Purified and Recombinant Proteins Services for PRDX2
    Novus Biologicals PRDX2 Proteins
    Novus Biologicals PRDX2 Lysates
    Sino Biological Recombinant Protein for PRDX2
    Sino Biological Cell Lysate for PRDX2 
    ProSpec Recombinant Protein for PRDX2
    Cloud-Clone Corp. Proteins for PRDX2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol IEA--

    PRDX2 for ontologies           About GeneDecksing



    PRDX2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX2
    R&D Systems Antibodies for PRDX2 (Peroxiredoxin 2)
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    Novus Biologicals PRDX2 Antibodies
    Abcam antibodies for PRDX2
    Cloud-Clone Corp. Antibodies for PRDX2 
    ThermoFisher Antibody for PRDX2
    LSBio Antibodies in human, mouse, rat for PRDX2 

    Assay Products for PRDX2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDX2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRDX2 
    Cloud-Clone Corp. CLIAs for PRDX2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry P32119

    ProtoNet protein and cluster: P32119

    1 Blocks protein domain: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX2_HUMAN, P32119
    Similarity: Belongs to the AhpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    PRDX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX2_HUMAN, P32119
    Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through
    the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in
    eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors
    and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH

         Enzyme Numbers (IUBMB): EC 1.11.1.151 2 EC 1.11.12

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008379thioredoxin peroxidase activity TAS18606987
    GO:0016209antioxidant activity NAS12943237
    GO:0016491oxidoreductase activity ----
    GO:0051920peroxiredoxin activity ----
         
    PRDX2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prdx2):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    PRDX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Prdx2tm1Yu for PRDX2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PRDX2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PRDX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX2
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDX2:
    hsa-miR-200c hsa-miR-429 hsa-miR-3176 hsa-miR-200b hsa-miR-4290 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidPRDX2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PRDX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRDX2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PRDX2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PRDX2 (see all 14)
    OriGene ORF clones in mouse, rat for PRDX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRDX2 (NM_005809)
    Sino Biological Human cDNA Clone for PRDX2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX2
    Sirion Biotech Customized lentivirus for stable overexpression of PRDX2 
                         Customized lentivirus expression plasmids for stable overexpression of PRDX2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PRDX2
    Search LifeMap BioReagents cell lines for PRDX2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PRDX2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    Prostaglandin 2 biosynthesis and metabolism FM0.42
    2PKA activation in glucagon signalling
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    3Selenium Pathway
    Selenium Pathway
    4Oxidative Stress Regulatory Pathway (Erythrocyte)
    Oxidative Stress Regulatory Pathway (Erythrocyte)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PRDX2
        Prostaglandin 2 biosynthesis and metabolism FM


    2 GeneGo (Thomson Reuters) Pathways for PRDX2
        Prostaglandin 2 biosynthesis and metabolism FM
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling

    1 BioSystems Pathway for PRDX2
        Selenium Pathway


    1 PharmGKB Pathway for PRDX2
        Oxidative Stress Regulatory Pathway (Erythrocyte)


    PRDX2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/185 Interacting proteins for PRDX2 (P321192, 3 ENSP000003015224) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TXNP105992, 3, ENSP000003636414MINT-5115275 I2D: score=3 STRING: ENSP00000363641
    SRXN1Q9BYN03, ENSP000003713884I2D: score=5 STRING: ENSP00000371388
    PDGFRBP096193, ENSP000002617994I2D: score=3 STRING: ENSP00000261799
    PPP2R1AP301533, ENSP000003248044I2D: score=3 STRING: ENSP00000324804
    PPP2R1BP301543, ENSP000003113444I2D: score=3 STRING: ENSP00000311344
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress NAS11904290
    GO:0019430removal of superoxide radicals IDA--
    GO:0034599cellular response to oxidative stress IDA--
    GO:0042744hydrogen peroxide catabolic process TAS18606987
    GO:0042981regulation of apoptotic process IMP12943237

    PRDX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRDX2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDX2

    2 HMDB Compounds for PRDX2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for PRDX2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-Sulfinoalanine-- 1115-65-7target--17139284 17016423
    N-Carbamoyl-Alanine-- --target--17139284 17016423

    10/21 Novoseek inferred chemical compound relationships for PRDX2 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ammonium molybdate 61.6 2 11410278 (1), 16839769 (1)
    glyceraldehyde 3-phosphate 61.4 6 18156650 (1), 18647502 (1), 17522728 (1), 16540677 (1) (see all 6)
    isocitrate 56 4 18647502 (1), 15292099 (1), 15936593 (1), 16009011 (1)
    h2o2 51.3 16 8663080 (4), 16045763 (3), 17329258 (2), 9356316 (2) (see all 9)
    oxygen 26.7 9 16288023 (2), 11152390 (1), 15259009 (1), 7607688 (1) (see all 7)
    superoxide 25.8 8 12401949 (1), 15158439 (1), 16372267 (1), 11762590 (1) (see all 8)
    trehalose 23.4 2 17522728 (1), 11410278 (1)
    nicotinamide 23.3 1 12555668 (1)
    dithiothreitol 11.9 7 8663080 (2), 8123012 (1)
    nad+ 11.3 1 15947248 (1)

    Search CenterWatch for drugs/clinical trials and news about PRDX2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRDX2 gene (3 alternative transcripts): 
    NM_005809.5  NM_181737.1  NM_181738.1  

    Unigene Cluster for PRDX2:

    Peroxiredoxin 2
    Hs.432121  [show with all ESTs]
    Unigene Representative Sequence: BM805899
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334482 ENST00000301522(uc002mvd.3) ENST00000466174(uc002mve.1)
    ENST00000498785 ENST00000478908 ENST00000477555 ENST00000435703
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDX2:
    hsa-miR-200c hsa-miR-429 hsa-miR-3176 hsa-miR-200b hsa-miR-4290 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidPRDX2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): PRDX2 (NM_005809)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX2
    Sirion Biotech Customized lentivirus for stable overexpression of PRDX2 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDX2

    Additional mRNA sequence: 

    AK289485.1 AK293957.1 BC000452.2 BC003022.1 BC039428.1 CR450356.1 CR541789.1 X82321.1 
    Z22548.1 

    23 DOTS entries:

    DT.40205724  DT.91770119  DT.92324962  DT.100883045  DT.100883050  DT.121434504  DT.95276743  DT.100883043 
    DT.100883038  DT.92047475  DT.99944330  DT.100060112  DT.100883036  DT.100883051  DT.100883052  DT.120789846 
    DT.121434506  DT.91770136  DT.91770137  DT.100737839  DT.121434510  DT.91770120  DT.95276744 

    24/1272 AceView cDNA sequences (see all 1272):

    AA293294 BF969934 CR602550 AI150338 BU184805 BF811159 CR600194 CR622487 
    BM709552 BI752960 BU664111 BU658896 BQ348553 BF813432 BQ348522 CR450356 
    BI117869 AU107633 AL528174 CA446214 BE618184 BF970279 BQ637224 BI850252 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
    SP1:                    -                       -                           
    SP2:                    -                       -     -                     
    SP3:                    -                                                   
    SP4:                    -                                                   
    SP5:                    -           -           -                           


    ECgene alternative splicing isoforms for PRDX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRDX2 expression in normal human tissues (normalized intensities)      PRDX2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCCACCTA
    PRDX2 Expression
    About this image


    PRDX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             brain/midbrain   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Trachea
             lung ; pneumocytes   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose/nasal cavity   

    See PRDX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRDX2

    SOURCE GeneReport for Unigene cluster: Hs.432121
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRDX2 (see all 7): 
              Parkinson's Disease in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRDX2 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx21 , 5 peroxiredoxin 21, 5 88.22(n)1
    93.43(a)1
      8 (41.40 cM)5
    216721  NM_011563.51  NP_035693.31 
     849695875 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343286.1(990031-1001683)
    zebrafish
    (Danio rerio)
    Actinopterygii prdx21 peroxiredoxin 2 72.96(n)
    77.04(a)
      791455  NM_001002468.1  NP_001002468.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jafrac11 , 3 redox homeostasis antioxidant3
    thioredoxin peroxidase 11
    69(a)
    (best of 4)3
    67.38(n)1
    71.28(a)1
      11E113
    535781  NM_058162.21  NP_477510.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F09E5.23
    prdx-21
    AHPC/TSA protein3
    Protein PRDX-21
    70(a)
    (best of 2)3
    67.01(n)1
    73.96(a)1
      II(5375241-5379466)3
    2668581  NM_001129132.11  NP_001122604.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TSA1(YML028W)4
    TSA11
    Thioredoxin peroxidase, acts as both a ribosome-associated more4
    Tsa1p1
    61.14(n)1
    66.84(a)1
      13(220138-220728)4
    8549801, 4  NP_013684.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G116301 2-Cys peroxiredoxin BAS1 61.35(n)
    64.36(a)
      820335  NM_111995.2  NP_187769.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05377001 hypothetical protein 61.52(n)
    62.23(a)
      4329578  NM_001053585.1  NP_001047050.1 


    ENSEMBL Gene Tree for PRDX2 (if available)
    TreeFam Gene Tree for PRDX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRDX2 gene
    PRDX32  PRDX12  PRDX42  
    3 SIMAP similar genes for PRDX2 using alignment to 2 protein entries:     PRDX2_HUMAN (see all proteins):
    PRDX1    PRDX4    PRDX3

    PRDX2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for PRDX2
    PGOHUM00000238721 PGOHUM00000248557 PGOHUM00000235866 PGOHUM00000260186


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/168 SNPs in PRDX2 are shown (see all 168)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342264781,2
    C,F--12844156(-) AGATAAGTTA/
            
    TGTGA
    1 -- ds50015Minor allele frequency- -:0.12NS 182
    rs357185911,2
    C,F,H--12844237(-) TGATCG/TTCTCT 1 -- ds500113Minor allele frequency- T:0.08NS NA WA 1020
    rs1161181141,2
    C,F--12844258(+) ACGGCA/GTTTGA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs801334121,2
    C,F--12844307(+) GCATGG/CCCAGA 1 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1872619111,2
    --12844479(+) CCTGAC/GCCTGA 1 -- ds50010--------
    rs1115481241,2
    C--12844541(+) GACTCT/ACACCT 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs31980341,2
    C--12844630(-) CCTCCA/CCCTAG 1 -- ut312Minor allele frequency- C:0.00MN NA 186
    rs1136074521,2
    C--12844646(+) GAAGGC/TCTTGG 1 -- ut310--------
    rs1126971741,2
    C--12844877(+) GCCAGA/C/G/
            
    GGGAC
    4 T P A S mis11CSA 1
    rs2016609331,2
    --12844901(+) ACACAA/GGGATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PRDX2 (12907634 - 12912694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRDX2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911077CNV Loss21882294
    dgv3733n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600538    OMIM disorders: --

    20/45 diseases for PRDX2 (see all 45):    About MalaCards
    fuchs' endothelial dystrophy    in situ carcinoma    pancreatic endocrine tumor    tauopathy
    bronchiolitis obliterans    vaginitis    bronchiolitis    idiopathic pulmonary fibrosis
    myasthenia gravis    endotheliitis    pulmonary fibrosis    vasculitis
    hemolytic anemia    migraine    polycystic ovary syndrome    down syndrome
    endometriosis    nasopharyngitis    infertility    acute myeloid leukemia


    PRDX2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for PRDX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 35.8 13 16038965 (2), 20363977 (2), 20477814 (1), 17124717 (1) (see all 10)
    tumors 13.1 6 15936593 (2), 18424265 (1), 19444892 (1), 18037904 (1)
    cancer 13 11 17679169 (3), 17600477 (3), 15986332 (1), 19016754 (1) (see all 7)
    breast cancer 6.45 3 7607688 (1), 11469800 (1), 16288023 (1)
    necrosis 2.26 1 18037904 (1)
    carcinoma squamous cell 0 1 15986332 (1)
    metastasis 0 2 16192647 (1), 15936593 (1)
    carcinoma 0 1 17443844 (1)

    Genetic Association Database (GAD): PRDX2
    Human Genome Epidemiology (HuGE) Navigator: PRDX2 (5 documents)

    Export disorders for PRDX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRDX2 gene, integrated from 9 sources (see all 219):
    (articles sorted by number of sources associating them with PRDX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. (PubMed id 7607688)1, 3, 9 Pahl P....Patterson D. (1995)
    2. The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. (PubMed id 8144038)1, 2, 9 Lim Y.-S.... Kim I.-H. (1994)
    3. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PubMed id 18682255)1, 4, 9 Schlawicke Engstrom K....Broberg K. (2008)
    4. Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and in fluence of genetic background in an Andean population exposed to high levels of arsenic. (PubMed id 19896490)1, 4 EngstrAPm K.S....Broberg K. (2010)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress. (PubMed id 12853451)1, 2 Chevallet M....Rabilloud T. (2003)
    10. Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. (PubMed id 11904290)1, 2 Rabilloud T.... Lunardi J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7001 HGNC: 9353 AceView: PRDX2 Ensembl:ENSG00000167815 euGenes: HUgn7001
    ECgene: PRDX2 H-InvDB: PRDX2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRDX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRDX2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/prdx2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRDX2 gene:
    Search GeneIP for patents involving PRDX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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