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Aliases for PRDX2 Gene

Aliases for PRDX2 Gene

  • Peroxiredoxin 2 2 3 5
  • Thioredoxin-Dependent Peroxide Reductase 1 2 3 4
  • Thioredoxin Peroxidase 1 2 3 4
  • Natural Killer Cell-Enhancing Factor B 3 4
  • Thiol-Specific Antioxidant 1 2 3
  • EC 1.11.1.15 4 63
  • NKEF-B 3 4
  • Torin 2 3
  • TDPX1 3 4
  • NKEFB 3 4
  • PRP 3 4
  • TSA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 2a 3
  • Thiol-Specific Antioxidant Protein 4
  • Natural Killer-Enhancing Factor B 2
  • EC 1.11.1 63
  • HEL-S-2a 3
  • PRXII 3
  • TPX1 3
  • PTX1 3
  • PRX2 3

External Ids for PRDX2 Gene

Previous HGNC Symbols for PRDX2 Gene

  • TDPX1

Previous GeneCards Identifiers for PRDX2 Gene

  • GC19M013039
  • GC19M013130
  • GC19M012752
  • GC19M012768
  • GC19M012907
  • GC19M012479

Summaries for PRDX2 Gene

Entrez Gene Summary for PRDX2 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

GeneCards Summary for PRDX2 Gene

PRDX2 (Peroxiredoxin 2) is a Protein Coding gene. Diseases associated with PRDX2 include hereditary spherocytosis and vaginal cancer. Among its related pathways are Gene Expression and Cellular Senescence. GO annotations related to this gene include oxidoreductase activity and peroxiredoxin activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot for PRDX2 Gene

  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Gene Wiki entry for PRDX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX2 Gene

Genomics for PRDX2 Gene

Regulatory Elements for PRDX2 Gene

Promoters for PRDX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRDX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRDX2 Gene

Chromosome:
19
Start:
12,796,820 bp from pter
End:
12,801,910 bp from pter
Size:
5,091 bases
Orientation:
Minus strand

Genomic View for PRDX2 Gene

Genes around PRDX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX2 Gene

Proteins for PRDX2 Gene

  • Protein details for PRDX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32119-PRDX2_HUMAN
    Recommended name:
    Peroxiredoxin-2
    Protein Accession:
    P32119
    Secondary Accessions:
    • A8K0C0
    • P31945
    • P32118
    • P35701
    • Q6FHG4
    • Q92763
    • Q9UC23

    Protein attributes for PRDX2 Gene

    Size:
    198 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
    Miscellaneous:
    • Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.
    • The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-172-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.

    Three dimensional structures from OCA and Proteopedia for PRDX2 Gene

    Alternative splice isoforms for PRDX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX2 Gene

Proteomics data for PRDX2 Gene at MOPED

Post-translational modifications for PRDX2 Gene

  • Ubiquitination at Lys 16, Lys 26, Lys 92, and Lys 135
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PRDX2 (Peroxiredoxin 2)

Domains & Families for PRDX2 Gene

Gene Families for PRDX2 Gene

Graphical View of Domain Structure for InterPro Entry

P32119

UniProtKB/Swiss-Prot:

PRDX2_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the AhpC/TSA family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the AhpC/TSA family.
genes like me logo Genes that share domains with PRDX2: view

Function for PRDX2 Gene

Molecular function for PRDX2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Enzyme Numbers (IUBMB) for PRDX2 Gene

Gene Ontology (GO) - Molecular Function for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051920 peroxiredoxin activity IEA --
genes like me logo Genes that share ontologies with PRDX2: view
genes like me logo Genes that share phenotypes with PRDX2: view

Animal Models for PRDX2 Gene

MGI Knock Outs for PRDX2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDX2 Gene

Localization for PRDX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX2 Gene COMPARTMENTS Subcellular localization image for PRDX2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
cytoskeleton 2
mitochondrion 2
chloroplast 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with PRDX2: view

Pathways & Interactions for PRDX2 Gene

genes like me logo Genes that share pathways with PRDX2: view

Gene Ontology (GO) - Biological Process for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006979 response to oxidative stress IEA,NAS 11904290
GO:0010467 gene expression TAS --
GO:0019430 removal of superoxide radicals IDA 20978343
GO:0034599 cellular response to oxidative stress IDA 20978343
genes like me logo Genes that share ontologies with PRDX2: view

No data available for SIGNOR curated interactions for PRDX2 Gene

Drugs & Compounds for PRDX2 Gene

(11) Drugs for PRDX2 Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-Sulfinoalanine Experimental Pharma Target 0
N-Carbamoyl-Alanine Experimental Pharma Target 0
calcium Nutra 0

(14) Additional Compounds for PRDX2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with PRDX2: view

Transcripts for PRDX2 Gene

Unigene Clusters for PRDX2 Gene

Peroxiredoxin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:

Relevant External Links for PRDX2 Gene

GeneLoc Exon Structure for
PRDX2
ECgene alternative splicing isoforms for
PRDX2

Expression for PRDX2 Gene

mRNA expression in normal human tissues for PRDX2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX2 Gene



SOURCE GeneReport for Unigene cluster for PRDX2 Gene Hs.432121

genes like me logo Genes that share expression patterns with PRDX2: view

Protein tissue co-expression partners for PRDX2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDX2 Gene

Orthologs for PRDX2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX2 36
  • 100 (a)
OneToOne
PRDX2 35
  • 99.83 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia PRDX2 36
  • 89 (a)
OneToOne
PRDX2 35
  • 87.39 (n)
  • 91.19 (a)
dog
(Canis familiaris)
Mammalia PRDX2 35
  • 88.22 (n)
  • 93.43 (a)
PRDX2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdx2 16
Gm5225 36
  • 72 (a)
OneToMany
Prdx2 36
  • 93 (a)
OneToMany
Prdx2 35
  • 88.22 (n)
  • 93.43 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDX2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx2 35
  • 87.04 (n)
  • 93.43 (a)
lizard
(Anolis carolinensis)
Reptilia PRDX2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx2 35
  • 72.43 (n)
  • 77.49 (a)
zebrafish
(Danio rerio)
Actinopterygii prdx2 35
  • 72.76 (n)
  • 76.65 (a)
prdx2 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TPX2 35
  • 65.97 (n)
  • 68.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6888 36
  • 58 (a)
ManyToMany
Jafrac1 36
  • 70 (a)
ManyToMany
CG6888 37
  • 57 (a)
Jafrac1 37
  • 69 (a)
Jafrac2 37
  • 67 (a)
Prx5037 37
  • 62 (a)
Jafrac1 35
  • 67.38 (n)
  • 71.28 (a)
worm
(Caenorhabditis elegans)
Secernentea prdx-2 36
  • 72 (a)
OneToMany
F09E5.2 37
  • 70 (a)
R07E5.2 37
  • 60 (a)
prdx-2 35
  • 66.67 (n)
  • 73.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 35
  • 61.14 (n)
  • 66.84 (a)
TSA1 36
  • 66 (a)
ManyToMany
TSA2 36
  • 61 (a)
ManyToMany
TSA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11630 35
  • 61.35 (n)
  • 64.36 (a)
rice
(Oryza sativa)
Liliopsida Os02g0537700 35
  • 61.52 (n)
  • 62.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tpx1 35
  • 60.85 (n)
  • 68.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for PRDX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX2 Gene

ENSEMBL:
Gene Tree for PRDX2 (if available)
TreeFam:
Gene Tree for PRDX2 (if available)

Paralogs for PRDX2 Gene

Paralogs for PRDX2 Gene

(3) SIMAP similar genes for PRDX2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PRDX2 Gene

genes like me logo Genes that share paralogs with PRDX2: view

Variants for PRDX2 Gene

Sequence variations from dbSNP and Humsavar for PRDX2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs34012472 - 12,799,911(-) GTGGA(G/T)GAGGC reference, missense
rs1804013 -- 12,797,002(-) GGTGC(C/T)CTATG utr-variant-3-prime
rs10407474 -- 12,799,091(+) AGACG(C/G)GGTTT intron-variant
rs34186581 -- 12,799,629(-) TATTG(C/G)CAGCA intron-variant
rs34226478 -- 12,796,437(-) AGATA(-/AGTTA)TGTGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRDX2 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294

Variation tolerance for PRDX2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX2 Gene

HapMap Linkage Disequilibrium report
PRDX2
Human Gene Mutation Database (HGMD)
PRDX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX2 Gene

Disorders for PRDX2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PRDX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hereditary spherocytosis
  • spherocytosis, type 1
vaginal cancer
  • malignant neoplasm of vagina
in situ carcinoma
  • carcinoma in situ
fuchs' endothelial dystrophy
  • fced
endothelial dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search PRDX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX2

Genetic Association Database (GAD)
PRDX2
Human Genome Epidemiology (HuGE) Navigator
PRDX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX2
genes like me logo Genes that share disorders with PRDX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX2 Gene

Publications for PRDX2 Gene

  1. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. (PMID: 7607688) Pahl P. … Patterson D. (Genomics 1995) 2 3 23 67
  2. Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis. (PMID: 20363977) Besgen P. … Prinz J.C. (J. Immunol. 2010) 3 23
  3. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) SchlAowicke EngstrAPm K. … Broberg K. (Mutat. Res. 2009) 3 23
  4. Chloramines and hypochlorous acid oxidize erythrocyte peroxiredoxin 2. (PMID: 19716412) Stacey M.M. … Winterbourn C.C. (Free Radic. Biol. Med. 2009) 3 23
  5. The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2. (PMID: 19061854) Manta B. … Denicola A. (Arch. Biochem. Biophys. 2009) 3 23

Products for PRDX2 Gene

Sources for PRDX2 Gene

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