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Aliases for PRDX2 Gene

Aliases for PRDX2 Gene

  • Peroxiredoxin 2 2 3
  • Thioredoxin-Dependent Peroxide Reductase 1 2 3 4
  • Thioredoxin Peroxidase 1 2 3 4
  • TDPX1 3 4 6
  • NKEFB 3 4 6
  • Natural Killer Cell-Enhancing Factor B 3 4
  • Thiol-Specific Antioxidant 1 2 3
  • EC 1.11.1.15 4 64
  • NKEF-B 3 4
  • Torin 2 3
  • PTX1 3 6
  • PRX2 3 6
  • PRP 3 4
  • TSA 3 4
  • Epididymis Secretory Sperm Binding Protein Li 2a 3
  • Thiol-Specific Antioxidant Protein 4
  • Natural Killer-Enhancing Factor B 2
  • Peroxiredoxin-2 3
  • EC 1.11.1 64
  • HEL-S-2a 3
  • PRXII 3
  • TPX1 3

External Ids for PRDX2 Gene

Previous Symbols for PRDX2 Gene

  • TDPX1

Summaries for PRDX2 Gene

Entrez Gene Summary for PRDX2 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

GeneCards Summary for PRDX2 Gene

PRDX2 (Peroxiredoxin 2) is a Protein Coding gene. Diseases associated with PRDX2 include fuchs endothelial dystrophy and in situ carcinoma. Among its related pathways are Cellular Senescence and Selenium Pathway. GO annotations related to this gene include antioxidant activity and thioredoxin peroxidase activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot for PRDX2 Gene

  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

Gene Wiki entry for PRDX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX2 Gene

Genomics for PRDX2 Gene

Genomic Location for PRDX2 Gene

Start:
12,796,820 bp from pter
End:
12,801,910 bp from pter
Size:
5,091 bases
Orientation:
Minus strand

Genomic View for PRDX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX2 Gene

Regulatory Elements for PRDX2 Gene

Proteins for PRDX2 Gene

  • Protein details for PRDX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32119-PRDX2_HUMAN
    Recommended name:
    Peroxiredoxin-2
    Protein Accession:
    P32119
    Secondary Accessions:
    • A8K0C0
    • P31945
    • P32118
    • P35701
    • Q6FHG4
    • Q92763
    • Q9UC23

    Protein attributes for PRDX2 Gene

    Size:
    198 amino acids
    Molecular mass:
    21892 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
    Miscellaneous:
    • Inactivated upon oxidative stress by overoxidation of Cys-51 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
    • The active site is the redox-active Cys-51 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-172-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin

    Three dimensional structures from OCA and Proteopedia for PRDX2 Gene

    Alternative splice isoforms for PRDX2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDX2 Gene

Proteomics data for PRDX2 Gene at MOPED

Post-translational modifications for PRDX2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys16, Lys26, Lys92, Lys119, and Lys135

Other Protein References for PRDX2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRDX2 Gene

UniProtKB/Swiss-Prot:

PRDX2_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • P32119
Family:
  • Belongs to the AhpC/TSA family.:
    • P32119
genes like me logo Genes that share domains with PRDX2: view

No data available for Gene Families for PRDX2 Gene

Function for PRDX2 Gene

Molecular function for PRDX2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH.
UniProtKB/Swiss-Prot Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)

Enzyme Numbers (IUBMB) for PRDX2 Gene

Gene Ontology (GO) - Molecular Function for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008379 thioredoxin peroxidase activity TAS 18606987
GO:0016209 antioxidant activity NAS 12943237
GO:0016491 oxidoreductase activity --
GO:0051920 peroxiredoxin activity --
genes like me logo Genes that share ontologies with PRDX2: view
genes like me logo Genes that share phenotypes with PRDX2: view

Animal Models for PRDX2 Gene

MGI Knock Outs for PRDX2:

miRNA for PRDX2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PRDX2 Gene

Localization for PRDX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX2 Gene COMPARTMENTS Subcellular localization image for PRDX2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with PRDX2: view

Pathways for PRDX2 Gene

genes like me logo Genes that share pathways with PRDX2: view

Pathways by source for PRDX2 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for PRDX2 Gene
1 BioSystems pathway for PRDX2 Gene

Gene Ontology (GO) - Biological Process for PRDX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006979 response to oxidative stress NAS 11904290
GO:0010467 gene expression TAS --
GO:0019430 removal of superoxide radicals IDA 20978343
genes like me logo Genes that share ontologies with PRDX2: view

Compounds for PRDX2 Gene

(2) HMDB Compounds for PRDX2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Water
  • Dihydrogen oxide
7732-18-5

(2) Drugbank Compounds for PRDX2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-Sulfinoalanine
1115-65-7 target
N-Carbamoyl-Alanine
target

(21) Novoseek inferred chemical compound relationships for PRDX2 Gene

Compound -log(P) Hits PubMed IDs
ammonium molybdate 61.6 2
glyceraldehyde 3-phosphate 61.4 6
isocitrate 56 4
h2o2 51.3 16
oxygen 26.7 8
genes like me logo Genes that share compounds with PRDX2: view

Transcripts for PRDX2 Gene

Unigene Clusters for PRDX2 Gene

Peroxiredoxin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:

Relevant External Links for PRDX2 Gene

GeneLoc Exon Structure for
PRDX2
ECgene alternative splicing isoforms for
PRDX2

Expression for PRDX2 Gene

mRNA expression in normal human tissues for PRDX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX2 Gene

SOURCE GeneReport for Unigene cluster for PRDX2 Gene Hs.432121

genes like me logo Genes that share expressions with PRDX2: view

Orthologs for PRDX2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRDX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX2 36
  • 99.83 (n)
  • 100 (a)
PRDX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDX2 36
  • 87.39 (n)
  • 91.19 (a)
PRDX2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX2 36
  • 88.22 (n)
  • 93.43 (a)
PRDX2 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5225 37
  • 72 (a)
OneToMany
Prdx2 36
  • 88.22 (n)
  • 93.43 (a)
Prdx2 16
Prdx2 37
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PRDX2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX2 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx2 36
  • 87.04 (n)
  • 93.43 (a)
lizard
(Anolis carolinensis)
Reptilia PRDX2 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdx2 36
  • 72.43 (n)
  • 77.49 (a)
zebrafish
(Danio rerio)
Actinopterygii prdx2 36
  • 72.76 (n)
  • 76.65 (a)
prdx2 37
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta TPX2 36
  • 65.97 (n)
  • 68.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6888 37
  • 58 (a)
ManyToMany
Jafrac1 36
  • 67.38 (n)
  • 71.28 (a)
Jafrac1 37
  • 70 (a)
ManyToMany
CG6888 38
  • 57 (a)
Prx5037 38
  • 62 (a)
Jafrac2 38
  • 67 (a)
Jafrac1 38
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea prdx-2 36
  • 66.67 (n)
  • 73.2 (a)
prdx-2 37
  • 72 (a)
OneToMany
R07E5.2 38
  • 60 (a)
F09E5.2 38
  • 70 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 36
  • 61.14 (n)
  • 66.84 (a)
TSA1 37
  • 66 (a)
ManyToMany
TSA1 39
TSA2 37
  • 61 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G11630 36
  • 61.35 (n)
  • 64.36 (a)
rice
(Oryza sativa)
Liliopsida Os02g0537700 36
  • 61.52 (n)
  • 62.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tpx1 36
  • 60.85 (n)
  • 68.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToMany
Species with no ortholog for PRDX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX2 Gene

ENSEMBL:
Gene Tree for PRDX2 (if available)
TreeFam:
Gene Tree for PRDX2 (if available)

Paralogs for PRDX2 Gene

Paralogs for PRDX2 Gene

Selected SIMAP similar genes for PRDX2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PRDX2 Gene

genes like me logo Genes that share paralogs with PRDX2: view

Variants for PRDX2 Gene

Sequence variations from dbSNP and Humsavar for PRDX2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1056648 -- 12,800,262(-) GCCCC(C/T)TGAAC reference, synonymous-codon
rs1057382 -- 12,796,937(-) GAGGG(C/G)TAGGC utr-variant-3-prime
rs1057443 -- 12,796,922(-) GCCTT(C/T)TCATG utr-variant-3-prime
rs1064144 -- 12,801,774(-) CGCGT(G/T)TGATC utr-variant-5-prime
rs1135005 -- 12,800,182(-) ATTGC(C/T)TACAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PRDX2 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294

Relevant External Links for PRDX2 Gene

HapMap Linkage Disequilibrium report
PRDX2
Human Gene Mutation Database (HGMD)
PRDX2

Disorders for PRDX2 Gene

(8) Novoseek inferred disease relationships for PRDX2 Gene

Disease -log(P) Hits PubMed IDs
shock 35.8 12
tumors 13.1 5
cancer 13 11
breast cancer 6.45 3
necrosis 2.26 1

Relevant External Links for PRDX2

Genetic Association Database (GAD)
PRDX2
Human Genome Epidemiology (HuGE) Navigator
PRDX2
genes like me logo Genes that share disorders with PRDX2: view

No data available for UniProtKB/Swiss-Prot for PRDX2 Gene

Publications for PRDX2 Gene

  1. Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. (PMID: 7607688) Pahl P. … Patterson D. (Genomics 1995) 2 3 23
  2. The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. (PMID: 8144038) Lim Y.-S. … Kim I.-H. (Gene 1994) 3 4 23
  3. Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions. (PMID: 18682255) SchlAowicke EngstrAPm K. … Broberg K. (Mutat. Res. 2009) 3 23 49
  4. [The biological function of peroxiredoxin II on Hep3B cells and its underlying mechanism]. (PMID: 18578994) Yue H.Y. … Liu Y.K. (Zhonghua Gan Zang Bing Za Zhi 2008) 3 23
  5. Presence of cytosolic peroxiredoxin 2 in the erythrocyte membrane of patients with hereditary spherocytosis. (PMID: 18387321) Rocha S. … Santos-Silva A. (Blood Cells Mol. Dis. 2008) 3 23

Products for PRDX2 Gene

  • Addgene plasmids for PRDX2

Sources for PRDX2 Gene

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