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Aliases for PRDX1 Gene

Aliases for PRDX1 Gene

  • Peroxiredoxin 1 2 3
  • Thioredoxin-Dependent Peroxide Reductase 2 3 4
  • Natural Killer Cell-Enhancing Factor A 3 4
  • Proliferation-Associated Gene Protein 3 4
  • Thioredoxin Peroxidase 2 3 4
  • EC 1.11.1.15 4 63
  • NKEF-A 3 4
  • TDPX2 3 4
  • PAGA 3 4
  • PAGB 3 4
  • PAG 3 4
  • Natural Killer-Enhancing Factor A 3
  • Proliferation-Associated Gene A 3
  • EC 1.11.1 63
  • MSP23 3
  • NKEFA 3
  • PRX1 3
  • PRXI 3

External Ids for PRDX1 Gene

Previous HGNC Symbols for PRDX1 Gene

  • PAGA

Previous GeneCards Identifiers for PRDX1 Gene

  • GC01M045704
  • GC01M044978
  • GC01M045404
  • GC01M045390
  • GC01M045645
  • GC01M045749
  • GC01M045976
  • GC01M044090

Summaries for PRDX1 Gene

Entrez Gene Summary for PRDX1 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PRDX1 Gene

PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Diseases associated with PRDX1 include cutaneous anthrax and anthrax disease. Among its related pathways are Glucose / Energy Metabolism and Cellular Senescence. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is PRDX2.

UniProtKB/Swiss-Prot for PRDX1 Gene

  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

Gene Wiki entry for PRDX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX1 Gene

Genomics for PRDX1 Gene

Regulatory Elements for PRDX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRDX1 Gene

Chromosome:
1
Start:
45,511,035 bp from pter
End:
45,523,047 bp from pter
Size:
12,013 bases
Orientation:
Minus strand

Genomic View for PRDX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX1 Gene

Proteins for PRDX1 Gene

  • Protein details for PRDX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06830-PRDX1_HUMAN
    Recommended name:
    Peroxiredoxin-1
    Protein Accession:
    Q06830
    Secondary Accessions:
    • B5BU26
    • D3DPZ8
    • P35703
    • Q2V576
    • Q5T154
    • Q5T155

    Protein attributes for PRDX1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22110 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2. Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity).
    Miscellaneous:
    • Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
    • The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
    SequenceCaution:
    • Sequence=CAI13097.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDX1 Gene

neXtProt entry for PRDX1 Gene

Proteomics data for PRDX1 Gene at MOPED

Post-translational modifications for PRDX1 Gene

  • Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • Ubiquitination at Lys 93
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDX1 Gene

Antibody Products

  • R&D Systems Antibodies for PRDX1 (Peroxiredoxin 1)
  • Cell Signaling Technology (CST) Antibodies for PRDX1 (PRDX1)

Domains & Families for PRDX1 Gene

Gene Families for PRDX1 Gene

Suggested Antigen Peptide Sequences for PRDX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q06830

UniProtKB/Swiss-Prot:

PRDX1_HUMAN :
  • Contains 1 thioredoxin domain.
  • Belongs to the AhpC/TSA family.
Domain:
  • Contains 1 thioredoxin domain.
Family:
  • Belongs to the AhpC/TSA family.
genes like me logo Genes that share domains with PRDX1: view

Function for PRDX1 Gene

Molecular function for PRDX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 R-SH + ROOH = R-S-S-R + H(2)O + ROH
UniProtKB/Swiss-Prot Function:
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
UniProtKB/Swiss-Prot Induction:
Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells

Enzyme Numbers (IUBMB) for PRDX1 Gene

Gene Ontology (GO) - Molecular Function for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity TAS --
GO:0005515 protein binding IPI 17909037
GO:0008379 thioredoxin peroxidase activity IDA 18606987
GO:0016209 antioxidant activity --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with PRDX1: view
genes like me logo Genes that share phenotypes with PRDX1: view

Animal Models for PRDX1 Gene

MGI Knock Outs for PRDX1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDX1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PRDX1 Gene

Localization for PRDX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX1 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX1 Gene COMPARTMENTS Subcellular localization image for PRDX1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 17603937
GO:0005737 cytoplasm IDA 17603937
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRDX1: view

Pathways & Interactions for PRDX1 Gene

genes like me logo Genes that share pathways with PRDX1: view

Pathways by source for PRDX1 Gene

1 Qiagen pathway for PRDX1 Gene
1 Cell Signaling Technology pathway for PRDX1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for PRDX1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001501 skeletal system development TAS 8089076
GO:0001895 retina homeostasis IEP 23580065
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006979 response to oxidative stress --
genes like me logo Genes that share ontologies with PRDX1: view

Drugs & Compounds for PRDX1 Gene

(5) Drugs for PRDX1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127
pyruvate Nutra 27
serine Nutra 420

(10) Additional Compounds for PRDX1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
glucose
glyceraldehyde 3-phosphate
H2O2
genes like me logo Genes that share compounds with PRDX1: view

Transcripts for PRDX1 Gene

Unigene Clusters for PRDX1 Gene

Peroxiredoxin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: -
SP10: - - -

Relevant External Links for PRDX1 Gene

GeneLoc Exon Structure for
PRDX1
ECgene alternative splicing isoforms for
PRDX1

Expression for PRDX1 Gene

mRNA expression in normal human tissues for PRDX1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX1 Gene



SOURCE GeneReport for Unigene cluster for PRDX1 Gene Hs.180909

genes like me logo Genes that share expression patterns with PRDX1: view

Protein tissue co-expression partners for PRDX1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDX1 Gene

Orthologs for PRDX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDX1 35
  • 93.63 (n)
  • 96.48 (a)
PRDX1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDX1 35
  • 93.3 (n)
  • 98.99 (a)
-- 36
  • 91 (a)
OneToMany
PRDX1 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Prdx1 35
  • 90.79 (n)
  • 95.48 (a)
Prdx1 16
Prdx1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRDX1 35
  • 99.66 (n)
  • 100 (a)
PRDX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx1 35
  • 91.29 (n)
  • 97.49 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDX1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDX1 35
  • 78.73 (n)
  • 88.44 (a)
PRDX1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731384 35
  • 76.21 (n)
  • 84.92 (a)
Str.493 35
zebrafish
(Danio rerio)
Actinopterygii hmzehl0637 35
prdx1 35
  • 73.91 (n)
  • 81.31 (a)
prdx1 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11565 35
fruit fly
(Drosophila melanogaster)
Insecta CG6888 37
  • 56 (a)
Jafrac1 37
  • 72 (a)
Jafrac2 37
  • 65 (a)
Prx5037 37
  • 61 (a)
CG6888 36
  • 55 (a)
ManyToMany
Jafrac1 36
  • 70 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F09E5.2 37
  • 74 (a)
R07E5.2 37
  • 65 (a)
prdx-2 36
  • 72 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 36
  • 59 (a)
ManyToMany
TSA2 36
  • 58 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToMany
Species with no ortholog for PRDX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX1 Gene

ENSEMBL:
Gene Tree for PRDX1 (if available)
TreeFam:
Gene Tree for PRDX1 (if available)

Paralogs for PRDX1 Gene

Paralogs for PRDX1 Gene

(4) SIMAP similar genes for PRDX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PRDX1 Gene

genes like me logo Genes that share paralogs with PRDX1: view

Variants for PRDX1 Gene

Sequence variations from dbSNP and Humsavar for PRDX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs488339 -- 45,512,064(+) TCTTA(A/T)TTttc intron-variant
rs571019 -- 45,520,679(+) AGATC(C/G)AGCCA intron-variant
rs713358 -- 45,522,595(+) ACTAC(C/G)CCCCA intron-variant, upstream-variant-2KB
rs1855621 -- 45,513,993(+) GAAGG(C/T)ATCTG intron-variant
rs2065708 -- 45,512,013(+) TAAGA(A/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX1 Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
esv2747819 CNV Deletion 23290073
esv1003037 CNV Deletion 20482838
esv2665399 CNV Deletion 23128226

Variation tolerance for PRDX1 Gene

Residual Variation Intolerance Score: 25.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDX1 Gene

HapMap Linkage Disequilibrium report
PRDX1
Human Gene Mutation Database (HGMD)
PRDX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDX1 Gene

Disorders for PRDX1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRDX1 Gene - From: DISEASES and NovoSeek

Disorder Aliases PubMed IDs
cutaneous anthrax
  • anthrax, skin type
anthrax disease
  • gas gangrene
- elite association
Search PRDX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRDX1

Genetic Association Database (GAD)
PRDX1
Human Genome Epidemiology (HuGE) Navigator
PRDX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDX1
genes like me logo Genes that share disorders with PRDX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDX1 Gene

Publications for PRDX1 Gene

  1. A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. (PMID: 8496166) Prosperi M.T. … Goubin G. (J. Biol. Chem. 1993) 2 23 67
  2. Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain. (PMID: 20096337) Joshi G. … Butterfield D.A. (Neuroscience 2010) 23 67
  3. Differential proteomics analysis of specific carbonylated proteins in the temporal cortex of aged rats: the deterioration of antioxidant system. (PMID: 19562484) Wang Q. … Ji J. (Neurochem. Res. 2010) 23 67
  4. Molecular proteomics imaging of tumor interfaces by mass spectrometry. (PMID: 19821573) Kang S. … Cho N.H. (J. Proteome Res. 2010) 23 67
  5. Of mice and men: comparative proteomics of bronchoalveolar fluid. (PMID: 20032019) Gharib S.A. … Schnapp L.M. (Eur. Respir. J. 2010) 23 67

Products for PRDX1 Gene

Sources for PRDX1 Gene

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