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Aliases for PRDX1 Gene

Aliases for PRDX1 Gene

  • Peroxiredoxin 1 2 3
  • PAGA 3 4 6
  • Thioredoxin-Dependent Peroxide Reductase 2 3 4
  • Natural Killer Cell-Enhancing Factor A 3 4
  • Proliferation-Associated Gene Protein 3 4
  • Thioredoxin Peroxidase 2 3 4
  • EC 1.11.1.15 4 64
  • NKEF-A 3 4
  • TDPX2 3 4
  • PAGB 3 4
  • PAG 3 4
  • Natural Killer-Enhancing Factor A 3
  • Proliferation-Associated Gene A 3
  • Peroxiredoxin-1 3
  • EC 1.11.1 64
  • MSP23 3
  • NKEFA 3
  • PRX1 3
  • PRXI 3

External Ids for PRDX1 Gene

Previous Symbols for PRDX1 Gene

  • PAGA

Summaries for PRDX1 Gene

Entrez Gene Summary for PRDX1 Gene

  • This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for PRDX1 Gene

PRDX1 (Peroxiredoxin 1) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Cellular Senescence. GO annotations related to this gene include protein homodimerization activity and peroxidase activity. An important paralog of this gene is PRDX2.

UniProtKB/Swiss-Prot for PRDX1 Gene

  • Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

Gene Wiki entry for PRDX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDX1 Gene

Genomics for PRDX1 Gene

Genomic Location for PRDX1 Gene

Start:
45,511,035 bp from pter
End:
45,523,047 bp from pter
Size:
12,013 bases
Orientation:
Minus strand

Genomic View for PRDX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDX1 Gene

Regulatory Elements for PRDX1 Gene

Proteins for PRDX1 Gene

  • Protein details for PRDX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06830-PRDX1_HUMAN
    Recommended name:
    Peroxiredoxin-1
    Protein Accession:
    Q06830
    Secondary Accessions:
    • B5BU26
    • D3DPZ8
    • P35703
    • Q2V576
    • Q5T154
    • Q5T155

    Protein attributes for PRDX1 Gene

    Size:
    199 amino acids
    Molecular mass:
    22110 Da
    Quaternary structure:
    • Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2. Interacts with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity).
    Miscellaneous:
    • Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
    • The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
    SequenceCaution:
    • Sequence=CAI13097.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDX1 Gene

neXtProt entry for PRDX1 Gene

Proteomics data for PRDX1 Gene at MOPED

Post-translational modifications for PRDX1 Gene

  • Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7, Lys27, Lys93, Lys136, and Lys178

Other Protein References for PRDX1 Gene

Domains for PRDX1 Gene

UniProtKB/Swiss-Prot:

PRDX1_HUMAN
Domain:
  • Contains 1 thioredoxin domain.:
    • Q06830
Family:
  • Belongs to the AhpC/TSA family.:
    • Q06830
genes like me logo Genes that share domains with PRDX1: view

No data available for Gene Families for PRDX1 Gene

Function for PRDX1 Gene

Molecular function for PRDX1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 2 R-SH + ROOH = R-S-S-R + H(2)O + ROH
UniProtKB/Swiss-Prot Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
UniProtKB/Swiss-Prot Induction: Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells

Enzyme Numbers (IUBMB) for PRDX1 Gene

Gene Ontology (GO) - Molecular Function for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004601 peroxidase activity TAS --
GO:0005515 protein binding IPI 17909037
GO:0008379 thioredoxin peroxidase activity IDA 18606987
GO:0016209 antioxidant activity --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with PRDX1: view
genes like me logo Genes that share phenotypes with PRDX1: view

Animal Models for PRDX1 Gene

MGI Knock Outs for PRDX1:

No data available for Transcription Factor Targeting and HOMER Transcription for PRDX1 Gene

Localization for PRDX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDX1 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDX1 Gene COMPARTMENTS Subcellular localization image for PRDX1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytoskeleton 2
cytosol 2
peroxisome 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 17603937
GO:0005719 nuclear euchromatin IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA 17603937
genes like me logo Genes that share ontologies with PRDX1: view

Pathways for PRDX1 Gene

genes like me logo Genes that share pathways with PRDX1: view

Pathways by source for PRDX1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for PRDX1 Gene
1 Qiagen pathway for PRDX1 Gene
1 Cell Signaling Technology pathway for PRDX1 Gene

Gene Ontology (GO) - Biological Process for PRDX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0001501 skeletal system development TAS 8089076
GO:0001895 retina homeostasis IEP 23580065
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006979 response to oxidative stress --
genes like me logo Genes that share ontologies with PRDX1: view

Compounds for PRDX1 Gene

(1) HMDB Compounds for PRDX1 Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5

(14) Novoseek inferred chemical compound relationships for PRDX1 Gene

Compound -log(P) Hits PubMed IDs
glyceraldehyde 3-phosphate 62.7 8
h2o2 52.4 2
manganese superoxide 42.8 1
oxygen 36.5 3
superoxide 27.1 6
genes like me logo Genes that share compounds with PRDX1: view

Transcripts for PRDX1 Gene

Unigene Clusters for PRDX1 Gene

Peroxiredoxin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDX1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - -
SP9: -
SP10: - - -

Relevant External Links for PRDX1 Gene

GeneLoc Exon Structure for
PRDX1
ECgene alternative splicing isoforms for
PRDX1

Expression for PRDX1 Gene

mRNA expression in normal human tissues for PRDX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDX1 Gene

SOURCE GeneReport for Unigene cluster for PRDX1 Gene Hs.180909

genes like me logo Genes that share expressions with PRDX1: view

Orthologs for PRDX1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRDX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDX1 36
  • 99.66 (n)
  • 100 (a)
PRDX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDX1 36
  • 93.63 (n)
  • 96.48 (a)
PRDX1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 91 (a)
OneToMany
PRDX1 36
  • 93.3 (n)
  • 98.99 (a)
PRDX1 37
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Prdx1 36
  • 90.79 (n)
  • 95.48 (a)
Prdx1 16
Prdx1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDX1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDX1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdx1 36
  • 91.29 (n)
  • 97.49 (a)
chicken
(Gallus gallus)
Aves PRDX1 36
  • 78.73 (n)
  • 88.44 (a)
PRDX1 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDX1 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731384 36
  • 76.21 (n)
  • 84.92 (a)
Str.493 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11565 36
zebrafish
(Danio rerio)
Actinopterygii hmzehl0637 36
prdx1 36
  • 73.91 (n)
  • 81.31 (a)
prdx1 37
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6888 37
  • 55 (a)
ManyToMany
Jafrac1 37
  • 70 (a)
ManyToMany
CG6888 38
  • 56 (a)
Prx5037 38
  • 61 (a)
Jafrac2 38
  • 65 (a)
Jafrac1 38
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea prdx-2 37
  • 72 (a)
OneToMany
R07E5.2 38
  • 65 (a)
F09E5.2 38
  • 74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSA1 37
  • 59 (a)
ManyToMany
TSA2 37
  • 58 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToMany
Species with no ortholog for PRDX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDX1 Gene

ENSEMBL:
Gene Tree for PRDX1 (if available)
TreeFam:
Gene Tree for PRDX1 (if available)

Paralogs for PRDX1 Gene

Paralogs for PRDX1 Gene

Selected SIMAP similar genes for PRDX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for PRDX1 Gene

genes like me logo Genes that share paralogs with PRDX1: view

Variants for PRDX1 Gene

Sequence variations from dbSNP and Humsavar for PRDX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs488339 -- 45,512,064(+) TCTTA(A/T)TTttc intron-variant
rs571019 -- 45,520,679(+) AGATC(C/G)AGCCA intron-variant
rs713358 -- 45,522,595(+) ACTAC(C/G)CCCCA intron-variant, upstream-variant-2KB
rs1855621 -- 45,513,993(+) GAAGG(C/T)ATCTG intron-variant
rs2065708 -- 45,512,013(+) TAAGA(A/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDX1 Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
esv2747819 CNV Deletion 23290073
esv1003037 CNV Deletion 20482838
esv2665399 CNV Deletion 23128226

Relevant External Links for PRDX1 Gene

HapMap Linkage Disequilibrium report
PRDX1
Human Gene Mutation Database (HGMD)
PRDX1

Disorders for PRDX1 Gene

(8) Novoseek inferred disease relationships for PRDX1 Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 49 2
anthrax 46.5 1
shock 27.1 8
cancer 26.2 4
thymoma 24.5 1

Relevant External Links for PRDX1

Genetic Association Database (GAD)
PRDX1
Human Genome Epidemiology (HuGE) Navigator
PRDX1
genes like me logo Genes that share disorders with PRDX1: view

No data available for UniProtKB/Swiss-Prot for PRDX1 Gene

Publications for PRDX1 Gene

  1. A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. (PMID: 8496166) Prosperi M.T. … Goubin G. (J. Biol. Chem. 1993) 2 3 4 23
  2. Cloning and sequence analysis of candidate human natural killer- enhancing factor genes. (PMID: 8026862) Shau H. … Kim A. (Immunogenetics 1994) 3 4 23
  3. Organization and chromosomal assignment of two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed pseudogene. (PMID: 8188254) ProspAcri M.T. … Goubin G. (Genomics 1994) 3 23
  4. Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology. (PMID: 17234762) Kim Y.J. … Park Y.M. (Cancer Res. 2007) 3 23
  5. Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. (PMID: 9388242) Jin D.-Y. … Jeang K.-T. (J. Biol. Chem. 1997) 3 23

Products for PRDX1 Gene

  • Addgene plasmids for PRDX1

Sources for PRDX1 Gene

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