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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRDX1 Gene

protein-coding   GIFtS: 66
GCID: GC01M045976

peroxiredoxin 1


(Previous symbol: PAGA)
 Explore 55 diseases affiliated with
PRDX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PRDX1    

Aliases
for PRDX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Peroxiredoxin 11 2     TDPX22 3
PAGA1 2 3 5     EC 1.11.1.153 8
NKEFA1 2     MSP232
Natural Killer Cell-Enhancing Factor A2 3     PRX12
Proliferation-Associated Gene Protein2 3     PRXI2
Thioredoxin Peroxidase 22 3     Natural Killer-Enhancing Factor A2
Thioredoxin-Dependent Peroxide Reductase 22 3     Peroxiredoxin-11
NKEF-A2 3     Proliferation-Associated Gene A2
PAG2 3     EC 1.11.18
PAGB2 3     

External Ids:    HGNC: 93521   Entrez Gene: 50522   Ensembl: ENSG000001174507   OMIM: 1767635   UniProtKB: Q068303   

Export aliases for PRDX1 gene to outside databases

Previous GC identifers: GC01M045704 GC01M044978 GC01M045404 GC01M045390 GC01M045645 GC01M045749 GC01M044090


Summaries
for PRDX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PRDX1:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl
hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the
antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer
development or progression. Four transcript variants encoding the same protein have been identified for this gene.
(provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830
Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during
metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by
regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates
the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)

Gene Wiki entry for PRDX1 (Peroxiredoxin 1)


Genomic Views
for PRDX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRDX1 gene promoter:
         NF-AT4   C/EBPbeta   PPAR-gamma1   SEF-1 (1)   Sox9   PPAR-gamma2   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRDX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PRDX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

PRDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045976:  view genomic region     (about GC identifiers)

Start:
 45,976,707 bp from pter      End:
 45,988,719 bp from pter
Size:
 12,013 bases      Orientation:
 minus strand

Proteins
for PRDX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830 (See protein sequence)
Recommended Name: Peroxiredoxin-1  
Size: 199 amino acids; 22110 Da
Subunit: Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2. Interacts with
GDPD5; forms a mixed-disulfide with GDPD5 (By similarity)
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I
to stage IV
Miscellaneous: The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH
of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be
subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is
retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
Sequence caution: Sequence=CAI13097.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for PRDX1:
2RII (3D)        3HY2 (3D)    
Secondary accessions: B5BU26 D3DPZ8 P35703 Q2V576 Q5T154 Q5T155

Explore the universe of human proteins at neXtProt for PRDX1: NX_Q06830

Post-translational modifications:

  • Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06830

    • 4/15 DME Specific Peptides for PRDX1 (Q06830) (see all 15)
     LSDYKGK  VGRSVDE  DFTFVCP  HGEVCPA 

    PRDX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001189360.1  NP_002565.1  NP_859047.1  NP_859048.1  

    ENSEMBL proteins: 
     ENSP00000361152   ENSP00000361150   ENSP00000407034   ENSP00000389047   ENSP00000262746  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins (see all 3): PRDX1
    OriGene Protein Over-expression Lysate (see all 4): PRDX1
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    Novus Biologicals PRDX1 Proteins
    Novus Biologicals PRDX1 Lysates
    Sino Biological Recombinant Protein for PRDX1
    ProSpec Recombinant Protein for PRDX1
    Uscn Proteins for PRDX1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17603937
    GO:0005719nuclear euchromatin IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA17603937
    GO:0005739mitochondrion IDA--


    PRDX1 for ontologies           About GeneDecksing



    PRDX1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX1
    R&D Systems Antibodies for PRDX1 (Peroxiredoxin 1)
    Cell Signaling Technology (CST) Antibodies for PRDX1  (NKEF-A)
    OriGene Antibodies (see all 2): PRDX1
    OriGene Custom Antibody Services for PRDX1 
    GenScript Custom Superior Antibodies Services for PRDX1
    Novus Biologicals PRDX1 Antibodies
    Abcam antibodies for PRDX1 
    Uscn Antibodies for PRDX1
    ThermoFisher Antibody for PRDX1

    Assay Products for PRDX1: 
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    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDX1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PRDX1

    Protein Domains /
    Families
    for PRDX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PRDX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry Q06830

    ProtoNet protein and cluster: Q06830

    1 Blocks protein family: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830
    Similarity: Belongs to the AhpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    Function
    for PRDX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830
    Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the
    thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during
    metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by
    regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates
    the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
    Induction: Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in
    untransformed and transformed cells

    Enzyme Numbers (IUBMB): EC 1.11.1.151 2 EC 1.11.12

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): PRDX1
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRDX1:
    hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: PRDX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRDX1 (see all 7)
    OriGene siRNA: PRDX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRDX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PRDX1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRDX1 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): PRDX1 (NM_181697)
    Sino Biological Human cDNA Clone for PRDX1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX1 

    Cell Line
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    Search LifeMap BioReagents cell lines for PRDX1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PRDX1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity IDA11986303
    GO:0005515protein binding IPI17909037
    GO:0008379thioredoxin peroxidase activity IDA18606987
    GO:0020037heme binding IEA--
    GO:0042802identical protein binding ----


    PRDX1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for PRDX1: Prdx1tm1Brs Prdx1tm1Rave
         7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Prdx1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  tumorigenesis 

    PRDX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PRDX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    		Prostaglandin 2 biosynthesis and metabolism FM0.44
    2Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00
    3Selenium Pathway
    		Selenium Pathway1.00
    4Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    5Peroxisome
    		Peroxisome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PRDX1
        Prostaglandin 2 biosynthesis and metabolism FM


    1 Cell Signaling Technology (CST) Pathway for PRDX1
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for PRDX1
        Prostaglandin 2 biosynthesis and metabolism FM

    3 BioSystems Pathways for PRDX1 
        Androgen receptor signaling pathway
    Selenium Pathway
    Coregulation of Androgen receptor activity


    1         Kegg Pathway  (Kegg details for PRDX1):
        Peroxisome


    PRDX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PRDX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/142 Interacting proteins for PRDX1 (Q068301, 2, 3 ENSP000002627464) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604842, 3, ENSP000003610214MINT-7266486 MINT-7266500 MINT-7266463 MINT-7266521 MINT-7266545 MINT-7266473 MINT-7266561 I2D: score=1 STRING: ENSP00000361021
    GAPDHP044062, 3, ENSP000002292394MINT-64057 I2D: score=5 STRING: ENSP00000229239
    ABL1P005192, 3, ENSP000003614234MINT-7213827 I2D: score=1 STRING: ENSP00000361423
    ADRM1Q161862, 3, ENSP000002530034MINT-3373635 I2D: score=1 STRING: ENSP00000253003
    ARP102751, 3, ENSP000003638224EBI-353193,EBI-608057 I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ----
    GO:0001501skeletal system development TAS8089076
    GO:0006979response to oxidative stress ----
    GO:0008283cell proliferation IEA--
    GO:0019430removal of superoxide radicals IEA--


    PRDX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PRDX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PRDX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRDX1

    1 HMDB Compound for PRDX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--
    10/14 Novoseek chemical compound relationships for PRDX1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 62.7 10 14997506 (1), 16220529 (1), 17988525 (1), 15986332 (1) (see all 8)
    h2o2 52.4 2 11469800 (1), 11764930 (1)
    manganese superoxide 42.8 1 16876904 (1)
    oxygen 36.5 3 17346242 (1), 17211829 (1), 19652395 (1)
    superoxide 27.1 7 18433156 (1), 15673657 (1), 18275859 (1), 15986332 (1) (see all 6)
    pyruvate 24.8 1 17196136 (1)
    malate 21.3 4 17098281 (1), 16947118 (1)
    etoposide 17.7 3 11469800 (1), 11764930 (1), 15682461 (1)
    dexamethasone 3.9 2 11469800 (1), 11764930 (1)
    glucose 0 1 20434969 (1)

    Search CenterWatch for drugs/clinical trials and news about PRDX1 

    Transcripts
    for PRDX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PRDX1 gene (4 alternative transcripts): 
    NM_001202431.1  NM_002574.3  NM_181696.2  NM_181697.2  

    Unigene Cluster for PRDX1:

    Peroxiredoxin 1
    Hs.180909  [show with all ESTs]
    Unigene Representative Sequence: BQ225838
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319248 ENST00000372079 ENST00000447184 ENST00000424390 ENST00000483583
    ENST00000262746(uc001coc.3 uc001cob.3 uc001coa.3 uc021omw.1)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDX1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate PRDX1:
    hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmid: PRDX1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB451262.1 AB451388.1 AK131049.1 AK311898.1 BC007063.1 BC021683.1 BT019740.1 CR407652.1 
    L19184.1 X67951.1 

    24/41 DOTS entries (see all 41):

    DT.97868401  DT.100032444  DT.97817552  DT.91802004  DT.100893820  DT.91801775  DT.100893822  DT.100893814 
    DT.92028107  DT.91801627  DT.121402070  DT.100893799  DT.121402084  DT.91801643  DT.100893801  DT.100893806 
    DT.91801657  DT.100836127  DT.121402058  DT.450801  DT.100893808  DT.100893813  DT.121402011  DT.95124111 

    24/2330 AceView cDNA sequences (see all 2330):

    CB112023 AV729487 AV722736 BQ214212 BM691573 BQ436069 BQ431878 CD742851 
    BQ217489 BE386243 CB529159 D54043 CB050944 CB851522 BG167149 AA361845 
    NM_002574 BE780593 BG616060 BM876283 BU630631 BM510746 BE276990 BG493226 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PRDX1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c
    SP1:        -     -     -     -     -     -     -                 -                       -                           
    SP2:                                -     -     -                 -                       -                           
    SP3:                                -     -     -     -           -                       -                           
    SP4:                          -     -     -     -                 -                       -                           
    SP5:                                      -     -                 -                       -                           


    ECgene alternative splicing isoforms for PRDX1

    Expression
    for PRDX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRDX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAACAAAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PRDX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PRDX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PRDX1

    SOURCE GeneReport for Unigene cluster: Hs.180909
        SABiosciences Expression via Pathway-Focused PCR Arrays including PRDX1: 
              HIV Host Response in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PRDX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for PRDX1 gene from 10/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PRDX11 peroxiredoxin 1 78.73(n)
    88.44(a)    		   424598  XM_001233859.2  XP_001233860.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PRDX16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 4(110190635-110198218)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CD252816.12   -- 80.95(n)    CD252816.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hmzehl06372 hmzehl0637 75.63(n)   337710  CK354923.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Jafrac13 redox homeostasis antioxidant 72(a)
    (best of 4)    		   11E11   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F09E5.23 AHPC/TSA protein 74(a)
    (best of 2)    		   II(5375241-5379466)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TSA21 Tsa2p 58.55(n)
    59.79(a)    		   852064   NP_010741.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G116306
    2-Cys Prx B6
    		 2-Cys peroxiredoxin BAS1-like protein
    		 42(a)
    42(a)
    		 possible ortholog
    possible ortholog
    		 3(3672120-3674075)
    5(1919213-1921425)
    rice
    (Oryza sativa)    		 Liliopsida AK068919.12   -- 71.26(n)    AK068919.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ahpC6
    		 alkyl hydroperoxide reductase, C22 subunit
    		 35(a)
    		 possible ortholog
    		 Chromosome(638168-638731)


    ENSEMBL Gene Tree for PRDX1 (if available)
    TreeFam Gene Tree for PRDX1 (if available) 

    Paralogs
    for PRDX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRDX1 gene
    PRDX32  PRDX42  PRDX22  
    4 SIMAP similar genes for PRDX1 using alignment to 1 protein entry:     PRDX1_HUMAN:
    PRDX2    PRDX4    PRDX3    PRDX6

    PRDX1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PRDX1
    PGOHUM00000235965


    Genomic Variants
    for PRDX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/306 NCBI SNPs in PRDX1 are shown (see all 306)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs345198981,2
    		F--45976235(-) TCTTA-/AGCCTT 5 -- int1 ut315Minor allele frequency- A:0.02NS 186
    rs127289191,2
    		C,F,--45976249(+) GCCCAG/ATACTG 5 -- ut31 int19Minor allele frequency- A:0.07NS NA 312
    rs57738831,2
    		C,F,--45976263(+) ACTACT/-GAAAG 5 -- ut31 int16Minor allele frequency- -:0.23NS NA 188
    rs2015784901,2
    		C--45976263(+) AACTAC/TGNNNN 5 -- ut31 int10--------
    rs1923337471,2
    		--45976374(+) CAGAAA/GAGGCC 5 -- ut31 int10--------
    rs79031,2
    		C,F,O,A,H,--45976472(+) ACCCAC/GCCTGT 5 -- int1 ut3123Minor allele frequency- G:0.50MN NA EA NS CSA WA 1712
    rs361199801,2
    		C,F,--45976481(-) ACTGAC/TGCCAC 5 -- int1 ut315Minor allele frequency- T:0.02NS 190
    rs10447171,2
    		C,F,A,H,--45976587(+) CCTATG/ATCTAC 5 -- ut31 int127Minor allele frequency- A:0.19MN NA EA NS WA CSA 1260
    rs1484271661,2
    		--45976630(+) GCTCTC/TCTCAT 5 -- int1 ut310--------
    rs1134515121,2
    		F,--45976750(+) ACTACG/AAAAGA 5 -- ut31 ds50012Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for PRDX1 (45976707 - 45988719 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PRDX1: --

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    Disorders / Diseases
    for PRDX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PRDX1 for disorders           About GeneDecksing

    OMIM gene information: 176763    OMIM disorders: --

    20/55 diseases for PRDX1 (see all 55):    About MalaCards
    estrogen-receptor negative breast cancer    pyruvate kinase deficiency    abdominal aortic aneurysm    proliferative diabetic retinopathy
    aortic aneurysm    idiopathic pulmonary fibrosis    diabetic retinopathy    esophageal squamous cell carcinoma
    squamous cell carcinoma    pancreatic endocrine tumors    pleomorphic adenoma    pulmonary fibrosis
    papillary thyroid carcinoma    male breast cancer    thymoma    ulcerative colitis
    filariasis    thyroid carcinoma    breast cancer    down syndrome

    8 Novoseek disease relationships for PRDX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 49 3 8496166 (1), 8188254 (1)
    anthrax 46.5 1 16299323 (1)
    shock 27.1 8 17996735 (1), 15673657 (1), 12748951 (1), 18329347 (1) (see all 8)
    cancer 26.2 4 18549262 (2), 12861054 (1), 17234762 (1)
    thymoma 24.5 1 11764930 (1)
    tumors 22.9 12 16278420 (3), 18549262 (2), 17988525 (1), 8627051 (1) (see all 6)
    cancer lung 18.3 1 18413821 (1)
    edema 0 1 15793101 (1)

    Human Genome Epidemiology (HuGE) Navigator: PRDX1 (4 documents)

    Export disorders for PRDX1 gene to outside databases

    Publications
    for PRDX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRDX1 gene, integrated from 9 sources (see all 206):
    (articles sorted by number of sources associating them with PRDX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. (PubMed id 8496166)1, 2, 3, 9 Prosperi M.T.... Goubin G. (1993)
    2. Cloning and sequence analysis of candidate human natural killer- enhancing factor genes. (PubMed id 8026862)1, 2, 9 Shau H.... Kim A. (1994)
    3. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress. (PubMed id 12853451)1, 2 Chevallet M....Rabilloud T. (2003)
    7. Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation. (PubMed id 12714748)1, 2 Woo H.A....Rhee S.G. (2003)
    8. Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid. (PubMed id 12161445)1, 2 Yang K.S....Rhee S.G. (2002)
    9. Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation. (PubMed id 11986303)1, 2 Chang T.-S.... Rhee S.G. (2002)
    10. A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. (PubMed id 12059788)1, 2 Wagner E.... Rabilloud T. (2002)

    External Searches for PRDX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PRDX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5052 HGNC: 9352 AceView: PRDX1 Ensembl:ENSG00000117450 euGenes: HUgn5052
    ECgene: PRDX1 Kegg: 5052 H-InvDB: PRDX1

    Other Databases showing PRDX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PRDX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRDX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRDX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/prdx1/

    Intellectual Property
    for PRDX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PRDX1 gene:
    Search GeneIP for patents involving PRDX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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