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PRDX1 Gene

protein-coding   GIFtS: 71
GCID: GC01M045976

Peroxiredoxin 1


(Previous symbol: PAGA)
  Search for PRDX1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Peroxiredoxin 11 2     EC 1.11.1.153 8
PAGA1 2 3 5     MSP232
Natural Killer Cell-Enhancing Factor A2 3     NKEFA2
Proliferation-Associated Gene Protein2 3     PRX12
Thioredoxin Peroxidase 22 3     PRXI2
Thioredoxin-Dependent Peroxide Reductase 22 3     Natural Killer-Enhancing Factor A2
NKEF-A2 3     peroxiredoxin-12
PAG2 3     Proliferation-Associated Gene A2
PAGB2 3     EC 1.11.18
TDPX22 3     

External Ids:    HGNC: 93521   Entrez Gene: 50522   Ensembl: ENSG000001174507   OMIM: 1767635   UniProtKB: Q068303   

Export aliases for PRDX1 gene to outside databases

Previous GC identifers: GC01M045704 GC01M044978 GC01M045404 GC01M045390 GC01M045645 GC01M045749 GC01M044090


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRDX1 Gene:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and
alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to
the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer
development or progression. Four transcript variants encoding the same protein have been identified for this
gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for PRDX1 Gene:
PRDX1 (peroxiredoxin 1) is a protein-coding gene. GO annotations related to this gene include peroxidase activity and protein homodimerization activity. An important paralog of this gene is PRDX3.

UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830
Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through
the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated
during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha
by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5
that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)

Gene Wiki entry for PRDX1 (Peroxiredoxin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDX1 gene promoter:
         NF-AT4   C/EBPbeta   PPAR-gamma1   SEF-1 (1)   Sox9   PPAR-gamma2   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDX1 promoter sequence
   Search Chromatin IP Primers for PRDX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

PRDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDX1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M045976:  view genomic region     (about GC identifiers)

Start:
45,976,707 bp from pter      End:
45,988,719 bp from pter
Size:
12,013 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830 (See protein sequence)
Recommended Name: Peroxiredoxin-1  
Size: 199 amino acids; 22110 Da
Subunit: Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2. Interacts
with GDPD5; forms a mixed-disulfide with GDPD5 (By similarity)
Miscellaneous: The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with
Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The
enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin
Miscellaneous: Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H.
Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized
Sequence caution: Sequence=CAI13097.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for PRDX1:
2RII (3D)        3HY2 (3D)    
Secondary accessions: B5BU26 D3DPZ8 P35703 Q2V576 Q5T154 Q5T155

Explore the universe of human proteins at neXtProt for PRDX1: NX_Q06830

Explore proteomics data for PRDX1 at MOPED

Post-translational modifications: 

  • Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity1
  • Ubiquitination2 at Lys7, Lys27, Lys93, Lys136, Lys178
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRDX1 (Q06830) (see all 15)
     LSDYKGK  VGRSVDE  DFTFVCP  HGEVCPA 


    See PRDX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001189360.1  NP_002565.1  NP_859047.1  NP_859048.1  

    ENSEMBL proteins: 
     ENSP00000361152   ENSP00000361150   ENSP00000407034   ENSP00000389047   ENSP00000262746  
    Reactome Protein details: Q06830

    PRDX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PRDX1
    OriGene Protein Over-expression Lysate for PRDX1
    OriGene MassSpec for PRDX1
    OriGene Custom Protein Services for PRDX1
    GenScript Custom Purified and Recombinant Proteins Services for PRDX1
    Novus Biologicals PRDX1 Proteins
    Novus Biologicals PRDX1 Lysates
    Sino Biological Recombinant Protein for PRDX1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PRDX1
    Cloud-Clone Corp. Proteins for PRDX1

     
    Search eBioscience for Proteins for PRDX1 

    PRDX1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDX1
    R&D Systems Antibodies for PRDX1 (Peroxiredoxin 1)
    Cell Signaling Technology (CST) Antibodies for PRDX1  (NKEF-A)
    OriGene Antibodies for PRDX1
    OriGene Custom Antibody Services for PRDX1
    Novus Biologicals PRDX1 Antibodies
    Abcam antibodies for PRDX1 (P30044, Q06830)
    Cloud-Clone Corp. Antibodies for PRDX1
    ThermoFisher Antibody for PRDX1
    LSBio Antibodies in human, mouse, rat for PRDX1

    PRDX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRDX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRDX1
    Cloud-Clone Corp. CLIAs for PRDX1
    Search eBioscience for ELISAs for PRDX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019479 Peroxiredoxin_C
     IPR012336 Thioredoxin-like_fold
     IPR000866 AhpC/TSA
     IPR024706 Peroxiredoxin_AhpC-typ

    Graphical View of Domain Structure for InterPro Entry Q06830

    ProtoNet protein and cluster: Q06830

    1 Blocks protein domain: IPB000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

    UniProtKB/Swiss-Prot: PRDX1_HUMAN, Q06830
    Similarity: Belongs to the AhpC/TSA family
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with PRDX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDX1_HUMAN, Q06830
    Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through
    the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated
    during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha
    by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5
    that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)
    Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH
    Induction: Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in
    untransformed and transformed cells

         Enzyme Numbers (IUBMB): EC 1.11.1.151 2 EC 1.11.12

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004601peroxidase activity IDA11986303
    GO:0005515protein binding IPI17909037
    GO:0008379thioredoxin peroxidase activity IDA18606987
    GO:0016209antioxidant activity ----
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with PRDX1           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prdx1):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with PRDX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PRDX1: Prdx1tm1Brs Prdx1tm1Rave

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRDX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRDX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRDX1:
    hsa-mir-1225-3p (MIRT036544), hsa-mir-18a-3p (MIRT040747), hsa-mir-23b-3p (MIRT046315), hsa-mir-375 (MIRT019836), hsa-mir-7-5p (MIRT025797), hsa-mir-100-5p (MIRT048535), hsa-mir-484 (MIRT041864)

    Block miRNA regulation of human, mouse, rat PRDX1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PRDX1:
    hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidPRDX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRDX1
    Predesigned siRNA for gene silencing in human, mouse, rat PRDX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRDX1

    Clone
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    OriGene clones in human, mouse for PRDX1 (see all 17)
    OriGene ORF clones in mouse, rat for PRDX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PRDX1 (NM_181697)
    Sino Biological Human cDNA Clone for PRDX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX1
    Addgene plasmids for PRDX1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PRDX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRDX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRDX1_HUMAN, Q06830: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytoskeleton2
    cytosol2
    peroxisome2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA17603937
    GO:0005719nuclear euchromatin IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA17603937

    Find genes that share ontologies with PRDX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRDX1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular responses to stress0.81
    2Selenium Pathway
    Selenium Pathway
    3Prostaglandin 2 biosynthesis and metabolism FM
    Prostaglandin 2 biosynthesis and metabolism FM
    4Peroxisome
    Peroxisome
    5Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with PRDX1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PRDX1
        TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for PRDX1
        Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for PRDX1
        Prostaglandin 2 biosynthesis and metabolism FM

    3 BioSystems Pathways for PRDX1
        Androgen receptor signaling pathway
    Selenium Pathway
    Coregulation of Androgen receptor activity


    1 Reactome Pathway for PRDX1
        Detoxification of Reactive Oxygen Species


    1 Kegg Pathway  (Kegg details for PRDX1):
        Peroxisome

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRDX1: 
              HIV Host Response in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRDX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRDX1 (Q068301, 2, 3 ENSP000002627464) via UniProtKB, MINT, STRING, and/or I2D (see all 234)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604841, 2, 3, ENSP000003610214EBI-353193,EBI-696162 MINT-7266486 MINT-7266500 MINT-7266463 MINT-7266521 MINT-7266545 MINT-7266473 MINT-7266561 I2D: score=1 STRING: ENSP00000361021
    GAPDHP044062, 3, ENSP000002292394MINT-64057 I2D: score=5 STRING: ENSP00000229239
    ABL1P005192, 3, ENSP000003614234MINT-7213827 I2D: score=1 STRING: ENSP00000361423
    ADRM1Q161862, 3, ENSP000002530034MINT-3373635 I2D: score=1 STRING: ENSP00000253003
    ARP102751, 3, ENSP000003638224EBI-353193,EBI-608057 I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302response to reactive oxygen species ----
    GO:0001501skeletal system development TAS8089076
    GO:0001895retina homeostasis IEP--
    GO:0006979response to oxidative stress ----
    GO:0008283cell proliferation IEA--

    Find genes that share ontologies with PRDX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDX1

    1 HMDB Compound for PRDX1    About this table
    CompoundSynonyms CAS #PubMed Ids
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Selected Novoseek inferred chemical compound relationships for PRDX1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glyceraldehyde 3-phosphate 62.7 10 14997506 (1), 16220529 (1), 17988525 (1), 15986332 (1) (see all 8)
    h2o2 52.4 2 11469800 (1), 11764930 (1)
    manganese superoxide 42.8 1 16876904 (1)
    oxygen 36.5 3 17346242 (1), 17211829 (1), 19652395 (1)
    superoxide 27.1 7 18433156 (1), 15673657 (1), 18275859 (1), 15986332 (1) (see all 6)
    pyruvate 24.8 1 17196136 (1)
    malate 21.3 4 17098281 (1), 16947118 (1)
    etoposide 17.7 3 11469800 (1), 11764930 (1), 15682461 (1)
    dexamethasone 3.9 2 11469800 (1), 11764930 (1)
    glucose 0 1 20434969 (1)



    Find genes that share compounds with PRDX1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRDX1 gene (4 alternative transcripts): 
    NM_001202431.1  NM_002574.3  NM_181696.2  NM_181697.2  

    Unigene Cluster for PRDX1:

    Peroxiredoxin 1
    Hs.180909  [show with all ESTs]
    Unigene Representative Sequence: BQ225838
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319248 ENST00000372079 ENST00000447184 ENST00000424390 ENST00000483583
    ENST00000262746(uc001coc.3 uc001cob.3 uc001coa.3 uc021omw.1)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate PRDX1:
    hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidPRDX1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): PRDX1 (NM_181697)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDX1
    Addgene plasmids for PRDX1 
    Primer
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    OriGene qPCR primer pairs and template standards for PRDX1
    OriGene qSTAR qPCR primer pairs in human, mouse for PRDX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDX1
      QuantiTect SYBR Green Assays in human, mouse, rat PRDX1
      QuantiFast Probe-based Assays in human, mouse, rat PRDX1

    Additional mRNA sequence: 

    AB451262.1 AB451388.1 AK131049.1 AK311898.1 BC007063.1 BC021683.1 BT019740.1 CR407652.1 
    L19184.1 X67951.1 

    Selected DOTS entries (see all 41):

    DT.97868401  DT.100032444  DT.97817552  DT.91802004  DT.100893820  DT.91801775  DT.100893822  DT.100893814 
    DT.92028107  DT.91801627  DT.121402070  DT.100893799  DT.121402084  DT.91801643  DT.100893801  DT.100893806 
    DT.91801657  DT.100836127  DT.121402058  DT.450801  DT.100893808  DT.100893813  DT.121402011  DT.95124111 

    Selected AceView cDNA sequences (see all 2330):

    R94833 BU630631 CR620467 BE386243 BF683909 N42935 CB114057 BM699750 
    AA037569 BG166293 BU069863 BQ026451 BM824503 AA379155 BM839013 AI365069 
    BM694150 BG121416 BM843981 AA362055 CB160544 BQ889150 AA976529 BU526813 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRDX1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c
    SP1:        -     -     -     -     -     -     -                 -                       -                           
    SP2:                                -     -     -                 -                       -                           
    SP3:                                -     -     -     -           -                       -                           
    SP4:                          -     -     -     -                 -                       -                           
    SP5:                                      -     -                 -                       -                           


    ECgene alternative splicing isoforms for PRDX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRDX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACAAAAC
    PRDX1 Expression
    About this image


    PRDX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Kidney (Urinary System)
             Metanephros
    PRDX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180909
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PRDX1: 
              HIV Host Response in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PRDX1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdx11 , 5 peroxiredoxin 11, 5 90.79(n)1
    95.48(a)1
      4 (53.28 cM)5
    184771  NM_011034.41  NP_035164.11 
     1166855445 
    chicken
    (Gallus gallus)
    Aves PRDX11 peroxiredoxin 1 78.73(n)
    88.44(a)
      424598  NM_001271932.1  NP_001258861.1 
    lizard
    (Anolis carolinensis)
    Reptilia PRDX16
    peroxiredoxin 1
    87(a)
    1 ↔ 1
    4(110187267-110198218)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD252816.12   -- 80.95(n)    CD252816.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzehl06372 hmzehl0637 75.63(n)   337710  CK354923.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jafrac13 redox homeostasis antioxidant 72(a)
    (best of 4)
      11E11   --
    worm
    (Caenorhabditis elegans)
    Secernentea F09E5.23 AHPC/TSA protein 74(a)
    (best of 2)
      II(5375241-5379466)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TSA16
    TSA26
    Thioredoxin peroxidase, acts as both a ribosome-as...
    Stress inducible cytoplasmic thioredoxin peroxidas...
    59(a)
    58(a)
    many ↔ many
    many ↔ many
    XIII(220138-220728) YML028W
    IV(1365072-1365662) YDR453C
    soybean
    (Glycine max)
    eudicotyledons 467835512   -- 71.85(n)  
    rice
    (Oryza sativa)
    Liliopsida AK068919.12   -- 71.26(n)    AK068919.1 


    ENSEMBL Gene Tree for PRDX1 (if available)
    TreeFam Gene Tree for PRDX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRDX1 gene
    PRDX32  PRDX42  PRDX22  
    4 SIMAP similar genes for PRDX1 using alignment to 1 protein entry:     PRDX1_HUMAN:
    PRDX2    PRDX4    PRDX3    PRDX6

    Find genes that share paralogs with PRDX1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PRDX1
    PGOHUM00000235965


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRDX1 (see all 327)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358876201,2
    C,F--45977256(-) ATTATAT/-GTTTG 4 -- int15Minor allele frequency- -:0.07NS 190
    rs106104501,2
    C--45977257(+) ACATA-/TAATCAT 4 -- int10--------
    rs358085631,2
    C,F--45977265(-) TGGTGA/GTGATT 4 -- int15Minor allele frequency- G:0.03NS 190
    rs782334551,2
    C--45977512(+) ACTCTA/CCCAAA 4 -- int10--------
    rs342455831,2
    C,F--45977528(-) GGTTCA/TGGCTA 4 -- int16Minor allele frequency- T:0.01NS CSA 192
    rs3733555681,2
    C--45977531(+) CCTGAA/CCTTAT 4 -- int10--------
    rs1478453911,2
    C--45977558(+) TAACAC/GAAGCC 4 -- int10--------
    rs1909465671,2
    --45977602(+) CCTTGC/GTAAGC 4 -- int10--------
    rs20657081,2
    C,F,A,H--45977685(+) TAAGAA/GTGTGC 4 -- int130Minor allele frequency- G:0.10NS EA NA CSA WA 2808
    rs676830901,2
    C,F--45977803(+) TGGAGT/GACGGT 4 -- int16Minor allele frequency- G:0.29WA NA EA 248

    HapMap Linkage Disequilibrium report for PRDX1 (45976707 - 45988719 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PRDX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003037CNV Deletion20482838
    esv2665399CNV Deletion23128226
    esv2747819CNV Deletion23290073
    nsv829726CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDX1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176763    OMIM disorders: --


    Find genes that share disorders with PRDX1           About GenesLikeMe

    8 Novoseek inferred disease relationships for PRDX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 49 3 8496166 (1), 8188254 (1)
    anthrax 46.5 1 16299323 (1)
    shock 27.1 8 17996735 (1), 15673657 (1), 12748951 (1), 18329347 (1) (see all 8)
    cancer 26.2 4 18549262 (2), 12861054 (1), 17234762 (1)
    thymoma 24.5 1 11764930 (1)
    tumors 22.9 12 16278420 (3), 18549262 (2), 17988525 (1), 8627051 (1) (see all 6)
    cancer lung 18.3 1 18413821 (1)
    edema 0 1 15793101 (1)

    Genetic Association Database (GAD): PRDX1
    Human Genome Epidemiology (HuGE) Navigator: PRDX1 (4 documents)

    Export disorders for PRDX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRDX1 gene, integrated from 10 sources (see all 240):
    (articles sorted by number of sources associating them with PRDX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. (PubMed id 8496166)1, 2, 3, 9 Prosperi M.T.... Goubin G. (J. Biol. Chem. 1993)
    2. Cloning and sequence analysis of candidate human natural killer- enhancing factor genes. (PubMed id 8026862)1, 2, 9 Shau H.... Kim A. (Immunogenetics 1994)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Regeneration of peroxiredoxins during recovery after oxidative stress: only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress. (PubMed id 12853451)1, 2 Chevallet M....Rabilloud T. (J. Biol. Chem. 2003)
    10. Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation. (PubMed id 12714748)1, 2 Woo H.A....Rhee S.G. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5052 HGNC: 9352 AceView: PRDX1 Ensembl:ENSG00000117450 euGenes: HUgn5052
    ECgene: PRDX1 Kegg: 5052 H-InvDB: PRDX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRDX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRDX1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/prdx1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRDX1 gene:
    Search GeneIP for patents involving PRDX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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