Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PRDM9 Gene

protein-coding   GIFtS: 54
GCID: GC05P023558

PR Domain Containing 9

(Previous names: minisatellite binding protein 3, 115kDa, minisatellite binding...)
(Previous symbol: MSBP3)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
PR Domain Containing 91 2     PR-Domain Containing Protein 91
MSBP31 2     MEISETZ2
Minisatellite Binding Protein 3 (115kD)1 2     PRMD92
Minisatellite Binding Protein 3, 115kDa1 2     ZNF8992
PFM62 3     Histone-Lysine N-Methyltransferase PRDM92
PR Domain Zinc Finger Protein 92 3     PR Domain-Containing Protein 93
EC 2.1.1.433 8     

External Ids:    HGNC: 139941   Entrez Gene: 569792   Ensembl: ENSG000001642567   OMIM: 6097605   UniProtKB: Q9NQV73   

Export aliases for PRDM9 gene to outside databases

Previous GC identifers: GC05P023203 GC05P023959 GC05P023522 GC05P023568


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PRDM9 Gene:
The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins,
such as PRDM9, are often involved in transcriptional regulation (Jiang and Huang, 2000 (PubMed
10668202)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PRDM9 Gene:
PRDM9 (PR domain containing 9) is a protein-coding gene. GO annotations related to this gene include histone-lysine N-methyltransferase activity and nucleic acid binding. An important paralog of this gene is ZNF432.

UniProtKB/Swiss-Prot: PRDM9_HUMAN, Q9NQV7
Function: Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase
and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of
histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a
central role in the transcriptional activation of genes during early meiotic prophase (By similarity)

Gene Wiki entry for PRDM9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDM9 gene promoter:
         HSF1 (long)   LCR-F1   PPAR-gamma1   POU2F1   POU2F1b   POU2F1a   HSF1short   POU2F1c   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDM9 promoter sequence
   Search Chromatin IP Primers for PRDM9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDM9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p14   Ensembl cytogenetic band:  5p14.2   HGNC cytogenetic band: 5p14.2

PRDM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDM9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P023558:  view genomic region     (about GC identifiers)

Start:
23,507,264 bp from pter      End:
23,528,706 bp from pter
Size:
21,443 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PRDM9_HUMAN, Q9NQV7 (See protein sequence)
Recommended Name: Histone-lysine N-methyltransferase PRDM9  
Size: 894 amino acids; 103376 Da
Sequence caution: Sequence=AAF87242.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PRDM9:
4IJD (3D)    
Secondary accessions: B4DX22 Q27Q50

Explore the universe of human proteins at neXtProt for PRDM9: NX_Q9NQV7

Explore proteomics data for PRDM9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PRDM9 (Q9NQV7) (see all 5)
     EQNLVAFQ  CRECGRGF  QSVLLTHQR  GDEYGQELGI 


    See PRDM9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064612.2  
    ENSEMBL proteins: 
     ENSP00000425471   ENSP00000296682  
    Reactome Protein details: Q9NQV7

    PRDM9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PRDM9
    GenScript Custom Purified and Recombinant Proteins Services for PRDM9
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRDM9

     
    Search eBioscience for Proteins for PRDM9 

     
    antibodies-online proteins for PRDM9 (2 products) 

     
    antibodies-online peptides for PRDM9

    PRDM9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDM9
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PRDM9
    Novus Biologicals PRDM9 Antibody
    Abcam antibodies for PRDM9
    Cloud-Clone Corp. Antibodies for PRDM9
    ThermoFisher Antibodies for PRDM9
    antibodies-online antibodies for PRDM9 (18 products) 

    PRDM9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRDM9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRDM9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRDM9
    Cloud-Clone Corp. CLIAs for PRDM9
    Search eBioscience for ELISAs for PRDM9 
    antibodies-online kits for PRDM9 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 7):
     IPR003655 Krueppel-associated_box-rel
     IPR019041 SSXRD_motif
     IPR001214 SET_dom
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry Q9NQV7

    ProtoNet protein and cluster: Q9NQV7

    UniProtKB/Swiss-Prot: PRDM9_HUMAN, Q9NQV7
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 14 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB-related domain
    Similarity: Contains 1 SET domain


    Find genes that share domains with PRDM9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDM9_HUMAN, Q9NQV7
    Function: Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase
    and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of
    histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a
    central role in the transcriptional activation of genes during early meiotic prophase (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +
    N(6)-methyl-L-lysine-[histone]

         Enzyme Number (IUBMB): EC 2.1.1.431 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
    GO:0010844recombination hotspot binding IEA--
    GO:0018024histone-lysine N-methyltransferase activity ----
    GO:0042800histone methyltransferase activity (H3-K4 specific) IEA--
         
    Find genes that share ontologies with PRDM9           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PRDM9:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Prdm9):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with PRDM9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Prdm9tm1Ymat for PRDM9

       genOway: Develop your customized and physiologically relevant rodent model for PRDM9

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ADGGYAGYAGCATCT 

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PRDM9 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRDM9
    SwitchGear 3'UTR luciferase reporter plasmidPRDM9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRDM9
    Predesigned siRNA for gene silencing in human, mouse, rat PRDM9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRDM9

    Clone
    Products:
         
    OriGene clones in human, mouse for PRDM9 (see all 6)
    OriGene ORF clones in mouse, rat for PRDM9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRDM9 (NM_020227)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDM9
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRDM9

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRDM9
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRDM9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PRDM9_HUMAN, Q9NQV7: Nucleus (By similarity). Chromosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--

    Find genes that share ontologies with PRDM9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PRDM9 About    
    See pathways by source

    SuperPathContained pathways About
    1Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with PRDM9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PRDM9
        Meiotic recombination


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRDM9
    Interactions:

        Search GeneGlobe Interaction Network for PRDM9

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006311meiotic gene conversion IDA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007283spermatogenesis IEA--
    GO:0010845positive regulation of reciprocal meiotic recombination IMP--

    Find genes that share ontologies with PRDM9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDM9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PRDM9 gene: 
    NM_020227.2  

    Unigene Cluster for PRDM9:

    PR domain containing 9
    Hs.283096  [show with all ESTs]
    Unigene Representative Sequence: NM_020227
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502755 ENST00000296682(uc003jgo.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRDM9 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PRDM9
    SwitchGear 3'UTR luciferase reporter plasmidPRDM9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRDM9
    Predesigned siRNA for gene silencing in human, mouse, rat PRDM9
    Clone
    Products:
         
    OriGene clones in human, mouse for PRDM9 (see all 6)
    OriGene ORF clones in mouse, rat for PRDM9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRDM9 (NM_020227)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDM9
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRDM9
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PRDM9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDM9
      QuantiTect SYBR Green Assays in human, mouse, rat PRDM9
      QuantiFast Probe-based Assays in human, mouse, rat PRDM9

    Additional mRNA sequence: 

    AF275816.1 AK301776.1 DQ388610.1 

    1 DOTS entry:

    DT.91734208 

    4 AceView cDNA sequences:

    AF275816 NM_020227 AL704903 AL704902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PRDM9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAGGGAG
    PRDM9 Expression
    About this image

    PRDM9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDM9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283096
        Custom PCR Arrays for PRDM9
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PRDM9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDM9
    QuantiTect SYBR Green Assays in human, mouse, rat PRDM9
    QuantiFast Probe-based Assays in human, mouse, rat PRDM9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for PRDM9 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdm91 , 5 PR domain containing 91, 5 81.69(n)1
    73.78(a)1
      17 (8.95 cM)5
    2133891  NM_144809.21  NP_659058.21 
     155451195 


    ENSEMBL Gene Tree for PRDM9 (if available)
    TreeFam Gene Tree for PRDM9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PRDM9 gene
    ZNF4322  ZNF5892  ZNF1332  ENSG000002565662  ZNF3432  ZNF1692  HKR12  
    Selected SIMAP similar genes for PRDM9 using alignment to 37 protein entries:     PRDM9_HUMAN (see all proteins) (see all similar genes):
    PRDM7_V2    PRMD9    ZFS-5    ZFS-4    PRDM7    HKR1
    ZNF133    ZNF497    ZNF337    ZNF500    ZNF78L1    ZNF84
    HZF36    ZNF418    kr-znf3    ZNF436    ZNF432    DKFZp547L155

    Find genes that share paralogs with PRDM9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PRDM9 (see all 519)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs623427131,2
    F--23505746(+) GTTCTA/GTATAG 1 -- us2k13Minor allele frequency- G:0.06NA WA 240
    rs45260701,2
    H--23505805(+) ggtttG/Cacgta 1 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs1901382061,2
    C--23505816(+) CTCCCA/GTCTAT 1 -- us2k10--------
    rs1412996671,2
    --23505868(+) AGGAAG/TTAATT 1 -- us2k10--------
    rs1816709431,2
    --23505910(+) TTTTCC/TTCTTG 1 -- us2k10--------
    rs1871275531,2
    --23505970(+) TTAATA/GATAAC 1 -- us2k10--------
    rs1919471121,2
    --23506082(+) AGGTGA/GGGCCT 1 -- us2k10--------
    rs1470126101,2
    --23506538(+) TCCTCC/TTGCCC 1 -- us2k10--------
    rs1833714181,2
    C--23506833(+) GAGACA/TTTTGG 1 -- us2k10--------
    rs29736141,2
    C,F--23506940(+) GCCCAG/CAACAC 1 -- us2k14Minor allele frequency- C:0.12WA EA 242

    HapMap Linkage Disequilibrium report for PRDM9 (23507264 - 23528706 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PRDM9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729936CNV Deletion23290073
    esv2742915CNV Deletion23290073
    nsv880521CNV Gain21882294
    nsv7369OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): PRDM9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDM9
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDM9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609760    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PRDM9:
    Male infertility

    Find genes that share disorders with PRDM9           About GenesLikeMe

    Genetic Association Database (GAD): PRDM9
    Human Genome Epidemiology (HuGE) Navigator: PRDM9 (2 documents)

    Export disorders for PRDM9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PRDM9 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with PRDM9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. (PubMed id 18941885)1, 2, 4 Miyamoto T....Sengoku K. (J. Assist. Reprod. Genet. 2008)
    2. The yin-yang of PR-domain family genes in tumorigenesis. (PubMed id 10668202)1, 2, 3 Jiang G.L. and Huang S. (Histol. Histopathol. 2000)
    3. Single-nucleotide polymorphisms of the PRDM9 (MEISETZ) gene in patients with nonobstructive azoospermia. (PubMed id 19168450)1, 4 Irie S....Tanaka H. (J. Androl. 2009)
    4. Two hypervariable minisatellite DNA binding proteins. (PubMed id 2062643)1, 3 Wahls W.P....Moore P.D. (Nucleic Acids Res. 1991)
    5. PRDM9 gene polymorphism may not be associated with defective spermatogenesis in the Chinese Han population. (PubMed id 23190393)1 He X.J....Zhang X.J. (Syst Biol Reprod Med 2013)
    6. Recombination regulator PRDM9 influences the instability of its own coding sequence in humans. (PubMed id 23267059)1 Jeffreys A.J....Lam K.W. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. Rare allelic forms of PRDM9 associated with childhood leukemogenesis. (PubMed id 23222848)1 Hussin J.... Awadalla P. (Genome Res. 2013)
    8. Evaluation of PRDM9 variation as a risk factor for recurrent genomic disorders and chromosomal non-disjunction. (PubMed id 22643917)1 Borel C....Sharp A.J. (Hum. Genet. 2012)
    9. The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans. (PubMed id 22162947)1 SAcgurel L....Przeworski M. (PLoS Biol. 2011)
    10. Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. (PubMed id 21750151)1 Berg I.L....Jeffreys A.J. (Proc. Natl. Acad. Sci. U.S.A. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 56979 HGNC: 13994 AceView: PRDM9 Ensembl:ENSG00000164256 euGenes: HUgn56979
    ECgene: PRDM9 H-InvDB: PRDM9

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PRDM9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PRDM9 gene:
    Search GeneIP for patents involving PRDM9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of PRDM9
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PRDM9  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PRDM9  
     OriGene qSTAR qPCR primer pairs in human, mouse for PRDM9   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PRDM9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PRDM9   OriGene Custom Protein Services for PRDM9  

     
     
     Block miRNA regulation of human, mouse, rat PRDM9 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PRDM9
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDM9 Predesigned siRNA for gene silencing in human, mouse, rat PRDM9
     QuantiFast Probe-based Assays in human, mouse, rat PRDM9 QuantiTect SYBR Green Assays in human, mouse, rat PRDM9
     Custom PCR Arrays for PRDM9 Search Chromatin IP Primers for PRDM9
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDM9  Search GeneGlobe Interaction Network for PRDM9
     Regulatory tfbs in PRDM9 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PRDM9 GenScript cDNA clones with any tag delivered in your preferred vector for PRDM9
     GenScript Custom Assay Services for PRDM9 GenScript Custom overexpressing Cell Line Services for PRDM9
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PRDM9
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PRDM9 antibodies
     Antibodies for PRDM9
     See all of Abcam's Antibodies, Kits and Proteins for PRDM9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PRDM9
     Antibodies for PRDM9
     ELISAs for PRDM9
     CLIAs for PRDM9



     Browse ESI BIO Cell Lines and PureStem Progenitors for PRDM9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM9
     SwitchGear 3'UTR luciferase reporter plasmids for PRDM9
     SwitchGear Promoter luciferase reporter plasmids for PRDM9
     ThermoFisher Antibodies for PRDM9
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRDM9
     Browse compounds at ApexBio
     Search Addgene for plasmids for PRDM9
      Search eBioscience for proteins for PRDM9
      Search eBioscience for elisas for PRDM9
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for PRDM9
     antibodies-online antibodies for PRDM9 (18 products)
     antibodies-online kits for PRDM9 (6 products)
     antibodies-online peptides for PRDM9
     antibodies-online proteins for PRDM9 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PRDM9 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4