PRDM8 Gene
protein-coding GIFtS : 44
GCID: GC04 P081107
PR domain containing 8
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Aliasesfor PRDM8 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases PR Domain Containing 8 1 2 PFM52 3 PR Domain-Containing Protein 82 3 PR Domain Zinc Finger Protein 82 PR-Domain Containing Protein 82
Export aliases for PRDM8 gene to outside databases Previous GC identifers: GC04P080993 GC04P081391 GC04P081498 GC04P081564 GC04P081565 GC04P081462 GC04P081325 GC04P076850
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Summariesfor PRDM8 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8 Function : May be involved in transcriptional regulation
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Genomic Viewsfor PRDM8 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PRDM8 gene promoter: C/EBPbeta Nkx2-5 CUTL1 AP-2gamma GATA-1 c-Myb AP-2beta AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for PRDM8 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat PRDM8
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q21 Ensembl cytogenetic band: 4q21.21 HGNC cytogenetic band: 4q21 PRDM8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P081107: view genomic region
(about GC identifiers )
Start:
81,105,033 bp from pter
End:
81,125,483 bp from pter
Size:
20,451 bases
Orientation:
plus strand
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Proteinsfor PRDM8 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8 (See
protein sequence )Recommended Name: PR domain zinc finger protein 8 Size : 689 amino acids; 71663 Da
Subcellular location : Nucleus (By similarity)
Sequence caution : Sequence=AAF87241.1; Type=Frameshift; Positions=287;
Secondary accessions : A8K7X2 Q6IQ36Alternative splicing : 2 isoforms : Q9NQV8-1 Q9NQV8-2 Explore the universe of human proteins at neXtProt for PRDM8: NX_Q9NQV8 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NQV8 PRDM8 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001092873.1 NP_064611.3 ENSEMBL proteins: ENSP00000423985 ENSP00000425149 ENSP00000406998 ENSP00000339764 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
PRDM8 for ontologies About GeneDecksing PRDM8 Antibody Products: Assay Products for PRDM8:
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Protein
Domains / Familiesfor PRDM8 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
PRDM8 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NQV8 ProtoNet protein and cluster: Q9NQV8
UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8 Similarity : Contains 3 C2H2-type zinc fingersSimilarity : Contains 1 SET domain
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Functionfor PRDM8 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8 Function : May be involved in transcriptional regulation
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PRDM8 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PRDM8 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): PRDM8 (NM_001099403 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRDM8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PRDM8
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM8
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
PRDM8 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for PRDM8 :Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Prdm8) :
PRDM8 for phenotypes About GeneDecksing
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Pathways & Interactionsfor PRDM8 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRDM8 Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0021540 corpus callosum morphogenesis
IEA -- GO:0021957 corticospinal tract morphogenesis
IEA -- GO:0022008 neurogenesis
-- --
PRDM8 for ontologies About GeneDecksing
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Drugs & Compoundsfor PRDM8 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for PRDM8 Search CenterWatch for drugs/clinical trials and news about PRDM8
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Transcriptsfor PRDM8 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PRDM8 gene (2 alternative transcripts): NM_001099403.1 NM_020226.3 Unigene Cluster for PRDM8:
PR domain containing 8 Hs.373642 [show with all ESTs ] Unigene Representative Sequence: NM_020226 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000508965 ENST00000509375 ENST00000506547 ENST00000511825 ENST00000504452 (uc010ijo.3 )ENST00000508061 ENST00000511197 ENST00000515013 ENST00000507025 ENST00000415738 (uc003hmc.4 )ENST00000339711 (uc003hmb.4 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PRDM8 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PRDM8 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): PRDM8 (NM_001099403 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRDM8 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PRDM8
Additional cDNA sequence: AF275815.1 AK292137.1 BC027929.1 BC058908.1 BC071584.1
7 DOTS entries : DT.75133058 DT.426473
DT.456119 DT.91755370 DT.121260204 DT.95258339 DT.100707153 24/72 AceView cDNA sequences (see all 72 ):
BP360245 AI738440 BG059660 BC027929 BC058908 CR597213 AI738426 NM_020226 F09774 F05284 AW161646 AW160888 AI762043 AI079265 AW197623 C01405 H84086 AA000993 BX092578 BP349591 BI489104 AI436578 BE676846 BI913179 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PRDM8 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 SP1 :                                       -     SP2 :           -   -   -   -     -                   -     SP3 :             -                               SP4 :       -   -   -   -   -       -                       SP5 :                                          
ECgene alternative splicing isoforms for PRDM8
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Expression for PRDM8 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PRDM8 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATAATGAAA
About this image PRDM8 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See PRDM8 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PRDM8 SOURCE GeneReport for Unigene cluster: Hs.373642 SABiosciences Custom PCR Arrays for PRDM8 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for PRDM8Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat PRDM8 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PRDM8 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PRDM8 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM8
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Orthologsfor PRDM8 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for PRDM8 gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for PRDM8 (if available)TreeFam Gene Tree for PRDM8 (if available)
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Paralogsfor PRDM8 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PRDM8 gene ZNF488 2
PRDM8 for paralogs About GeneDecksing
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Genomic Variantsfor PRDM8 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for PRDM8 1 Indel : 68756 Human Gene Mutation Database (HGMD) : PRDM8 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing PRDM8
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Disorders
/ Diseasesfor PRDM8 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section PRDM8 for disorders About MalaCards
PRDM8 for disorders About GeneDecksing 2 diseases from the University of Copenhagen DISEASES database for PRDM8 :Unverricht-Lundborg syndrome Lafora disease Export disorders for PRDM8 gene to outside databases
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Publicationsfor PRDM8 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PRDM8 gene integrated from 9 sources : (articles sorted by number of sources associating them with PRDM8) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Early-onset Lafora body disease. (PubMed id 22961547) 1 Turnbull J....Minassian B.A. (2012) Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483) 1 Newton-Cheh C....Munroe P.B. (2009) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 1 Suzuki Y.... Sugano S. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) SET domains and histone methylation. (PubMed id 14675547) 1 Xiao B....Gamblin S.J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) The yin-yang of PR-domain family genes in tumorigenesis. (PubMed id 10668202) 1 Jiang G.L. and Huang S. (2000)
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External Searches for PRDM8 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing PRDM8 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing PRDM8 gene
(According to HUGE )
About This Section --
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Specialized Databases showing PRDM8 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for PRDM8 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for PRDM8 gene: Search GeneIP for patents involving PRDM8 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PRDM8 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for PRDM8 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for PRDM8 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for PRDM8 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PRDM8 OriGene 3'-UTR Clone for PRDM8 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for PRDM8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for PRDM8 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PRDM8 OriGene Custom Protein Services for PRDM8 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRDM8 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing PRDM8 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat PRDM8 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat PRDM8 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat PRDM8 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat PRDM8
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM8
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PRDM8
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