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Aliases for PRDM8 Gene

Aliases for PRDM8 Gene

  • PR Domain Containing 8 2 3
  • PR Domain-Containing Protein 8 3 4
  • PFM5 3 4
  • PR Domain Zinc Finger Protein 8 3
  • PR-Domain Containing Protein 8 3
  • EC 2.1.1.- 4

External Ids for PRDM8 Gene

Summaries for PRDM8 Gene

GeneCards Summary for PRDM8 Gene

PRDM8 (PR Domain Containing 8) is a Protein Coding gene. Diseases associated with PRDM8 include early-onset lafora body disease. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K9 specific).

UniProtKB/Swiss-Prot for PRDM8 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM8 Gene

Genomics for PRDM8 Gene

Genomic Location for PRDM8 Gene

80,183,879 bp from pter
80,204,329 bp from pter
20,451 bases
Plus strand

Genomic View for PRDM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM8 Gene

Regulatory Elements for PRDM8 Gene

Proteins for PRDM8 Gene

  • Protein details for PRDM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PR domain zinc finger protein 8
    Protein Accession:
    Secondary Accessions:
    • A8K7X2
    • Q6IQ36

    Protein attributes for PRDM8 Gene

    689 amino acids
    Molecular mass:
    71663 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF87241.1; Type=Frameshift; Positions=287; Evidence={ECO:0000305};

    Alternative splice isoforms for PRDM8 Gene


neXtProt entry for PRDM8 Gene

Proteomics data for PRDM8 Gene at MOPED

Post-translational modifications for PRDM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDM8 Gene

No data available for DME Specific Peptides for PRDM8 Gene

Domains for PRDM8 Gene

Protein Domains for PRDM8 Gene


Suggested Antigen Peptide Sequences for PRDM8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SET domain.:
    • Q9NQV8
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.:
    • Q9NQV8
  • Contains 3 C2H2-type zinc fingers.:
    • Q9NQV8
genes like me logo Genes that share domains with PRDM8: view

No data available for Gene Families for PRDM8 Gene

Function for PRDM8 Gene

Molecular function for PRDM8 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Enzyme Numbers (IUBMB) for PRDM8 Gene

Gene Ontology (GO) - Molecular Function for PRDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding --
GO:0042054 histone methyltransferase activity --
genes like me logo Genes that share ontologies with PRDM8: view

Phenotypes for PRDM8 Gene

genes like me logo Genes that share phenotypes with PRDM8: view

miRNA for PRDM8 Gene

miRTarBase miRNAs that target PRDM8

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRDM8 Gene

Localization for PRDM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM8 Gene

Subcellular locations from

Jensen Localization Image for PRDM8 Gene COMPARTMENTS Subcellular localization image for PRDM8 gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRDM8: view

Pathways for PRDM8 Gene

SuperPathways for PRDM8 Gene

No Data Available

Interacting Proteins for PRDM8 Gene

Gene Ontology (GO) - Biological Process for PRDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016571 histone methylation --
GO:0021540 corpus callosum morphogenesis IEA --
GO:0021952 central nervous system projection neuron axonogenesis --
GO:0021957 corticospinal tract morphogenesis IEA --
genes like me logo Genes that share ontologies with PRDM8: view

No data available for Pathways by source for PRDM8 Gene

Transcripts for PRDM8 Gene

Unigene Clusters for PRDM8 Gene

PR domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - - -
SP3: -
SP4: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -

Relevant External Links for PRDM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRDM8 Gene

mRNA expression in normal human tissues for PRDM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRDM8 Gene

SOURCE GeneReport for Unigene cluster for PRDM8 Gene Hs.373642

genes like me logo Genes that share expressions with PRDM8: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDM8 Gene

Orthologs for PRDM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRDM8 35
  • 97.93 (n)
  • 97.55 (a)
PRDM8 36
  • 87 (a)
(Bos Taurus)
Mammalia PRDM8 35
  • 91.87 (n)
  • 95.45 (a)
PRDM8 36
  • 64 (a)
(Canis familiaris)
Mammalia PRDM8 35
  • 89.35 (n)
  • 90.79 (a)
PRDM8 36
  • 87 (a)
(Mus musculus)
Mammalia Prdm8 35
  • 84.93 (n)
  • 88.63 (a)
Prdm8 16
Prdm8 36
  • 87 (a)
(Monodelphis domestica)
Mammalia PRDM8 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia PRDM8 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Prdm8 35
  • 84.61 (n)
  • 87.17 (a)
(Gallus gallus)
Aves PRDM8 36
  • 48 (a)
(Anolis carolinensis)
Reptilia PRDM8 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm8 35
  • 63.62 (n)
  • 67.93 (a)
(Danio rerio)
Actinopterygii prdm8b 35
  • 64.31 (n)
  • 67.26 (a)
prdm8b 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13287 36
  • 21 (a)
Species with no ortholog for PRDM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDM8 Gene

Gene Tree for PRDM8 (if available)
Gene Tree for PRDM8 (if available)

Paralogs for PRDM8 Gene

No data available for Paralogs for PRDM8 Gene

Variants for PRDM8 Gene

Sequence variations from dbSNP and Humsavar for PRDM8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12780 -- 80,203,442(-) CGCCG(C/G)CGCTT synonymous-codon, reference
rs930904 -- 80,199,018(+) TTTTT(A/T)AGTGA intron-variant
rs1139248 -- 80,200,086(+) ATGGA(G/T)GATAC reference, missense
rs1458042 -- 80,191,733(+) CACCT(C/T)TTCAT intron-variant
rs1458043 -- 80,192,041(+) TCTCT(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM8 Gene

Variant ID Type Subtype PubMed ID
esv29411 CNV Loss 19812545

Relevant External Links for PRDM8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM8 Gene

Disorders for PRDM8 Gene

(1) University of Copenhagen DISEASES for PRDM8 Gene

Relevant External Links for PRDM8

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PRDM8: view

No data available for UniProtKB/Swiss-Prot for PRDM8 Gene

Publications for PRDM8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 48
  3. Early-onset Lafora body disease. (PMID: 22961547) Turnbull J. … Minassian B.A. (Brain 2012) 3
  4. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3
  5. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 48

Products for PRDM8 Gene

Sources for PRDM8 Gene

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