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PRDM8 Gene

protein-coding   GIFtS: 47
GCID: GC04P081107

PR Domain Containing 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
PR Domain Containing 81 2
PFM52 3
PR Domain-Containing Protein 82 3
PR Domain Zinc Finger Protein 82
PR-Domain Containing Protein 82
EC 2.1.1.-3

External Ids:    HGNC: 139931   Entrez Gene: 569782   Ensembl: ENSG000001527847   UniProtKB: Q9NQV83   
ORGUL members:         

Export aliases for PRDM8 gene to outside databases

Previous GC identifers: GC04P080993 GC04P081391 GC04P081498 GC04P081564 GC04P081565 GC04P081462 GC04P081325 GC04P076850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PRDM8 Gene:
PRDM8 (PR domain containing 8) is a protein-coding gene. Diseases associated with PRDM8 include early-onset lafora body disease, and lafora disease. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K9 specific). An important paralog of this gene is ZNF488.

UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDM8 gene promoter:
         C/EBPbeta   Nkx2-5   CUTL1   AP-2gamma   GATA-1   c-Myb   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRDM8 promoter sequence
   Search Chromatin IP Primers for PRDM8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21   Ensembl cytogenetic band:  4q21.21   HGNC cytogenetic band: 4q21

PRDM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDM8 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P081107:  view genomic region     (about GC identifiers)

Start:
81,105,033 bp from pter      End:
81,125,483 bp from pter
Size:
20,451 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8 (See protein sequence)
Recommended Name: PR domain zinc finger protein 8  
Size: 689 amino acids; 71663 Da
Sequence caution: Sequence=AAF87241.1; Type=Frameshift; Positions=287;
Secondary accessions: A8K7X2 Q6IQ36
Alternative splicing: 2 isoforms:  Q9NQV8-1   Q9NQV8-2   

Explore the universe of human proteins at neXtProt for PRDM8: NX_Q9NQV8

Explore proteomics data for PRDM8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRDM8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001092873.1  NP_064611.3  

    ENSEMBL proteins: 
     ENSP00000423985   ENSP00000425149   ENSP00000406998   ENSP00000339764  

    PRDM8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRDM8

    PRDM8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for PRDM8 at Abcam
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    ThermoFisher Antibodies for PRDM8
    LSBio Antibodies in human, mouse, rat for PRDM8

    PRDM8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PRDM8
    Cloud-Clone Corp. CLIAs for PRDM8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001214 SET_dom
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NQV8

    ProtoNet protein and cluster: Q9NQV8

    UniProtKB/Swiss-Prot: PRDM8_HUMAN, Q9NQV8
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 3 C2H2-type zinc fingers
    Similarity: Contains 1 SET domain


    PRDM8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDM8_HUMAN, Q9NQV8
    Function: May be involved in transcriptional regulation

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----
    GO:0042054histone methyltransferase activity ----
         
    PRDM8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PRDM8:
     High actin ratio cells 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Prdm8):
     behavior/neurological  cellular  integument  nervous system 

    PRDM8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRDM8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRDM8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDM8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRDM8

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRDM8:
    hsa-mir-7-5p (MIRT025734)

    Block miRNA regulation of human, mouse, rat PRDM8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRDM8 (see all 31):
    hsa-miR-142-5p hsa-miR-875-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-16-2* hsa-miR-938 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidPRDM8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRDM8
    Predesigned siRNA for gene silencing in human, mouse, rat PRDM8

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for PRDM8

    Clone
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    OriGene clones in human, mouse for PRDM8 (see all 13)
    OriGene ORF clones in mouse, rat for PRDM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRDM8 (NM_001099403)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDM8

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PRDM8
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRDM8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRDM8_HUMAN, Q9NQV8: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    PRDM8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRDM8
    Interactions:

        Search GeneGlobe Interaction Network for PRDM8

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0016571histone methylation ----
    GO:0021540corpus callosum morphogenesis IEA--
    GO:0021952central nervous system projection neuron axonogenesis ----
    GO:0021957corticospinal tract morphogenesis IEA--

    PRDM8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDM8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRDM8 gene (2 alternative transcripts): 
    NM_001099403.1  NM_020226.3  

    Unigene Cluster for PRDM8:

    PR domain containing 8
    Hs.373642  [show with all ESTs]
    Unigene Representative Sequence: NM_020226
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508965 ENST00000509375 ENST00000506547 ENST00000511825 ENST00000504452(uc010ijo.3)
    ENST00000508061 ENST00000515013 ENST00000507025 ENST00000415738(uc003hmc.4)
    ENST00000339711(uc003hmb.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRDM8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRDM8 (see all 31):
    hsa-miR-142-5p hsa-miR-875-3p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-16-2* hsa-miR-938 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidPRDM8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRDM8
    Predesigned siRNA for gene silencing in human, mouse, rat PRDM8
    Clone
    Products:
         
    OriGene clones in human, mouse for PRDM8 (see all 13)
    OriGene ORF clones in mouse, rat for PRDM8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PRDM8 (NM_001099403)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDM8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRDM8
    OriGene qSTAR qPCR primer pairs in human, mouse for PRDM8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRDM8
      QuantiTect SYBR Green Assays in human, mouse, rat PRDM8
      QuantiFast Probe-based Assays in human, mouse, rat PRDM8

    Additional mRNA sequence: 

    AF275815.1 AK292137.1 BC027929.1 BC058908.1 BC071584.1 

    7 DOTS entries:

    DT.75133058  DT.426473  DT.456119  DT.91755370  DT.121260204  DT.95258339  DT.100707153 

    Selected AceView cDNA sequences (see all 72):

    BP360245 AW160888 F05284 AI738440 AW161646 CR597213 BC027929 BG059660 
    BC058908 AW197623 AI738426 AI762043 AI079265 NM_020226 F09774 BX092578 
    AI436578 BI489103 BX462055 H84085 BI757607 BE785115 BP349591 AF275815 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRDM8 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:                                                                                                                    -         
    SP2:                                -     -     -     -           -                                                     -         
    SP3:                                      -                                                                                       
    SP4:                    -     -     -     -     -                 -                                                               
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PRDM8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRDM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATGAAA
    PRDM8 Expression
    About this image


    PRDM8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             PureStem 4D20.8, NCr-fac Progenitor
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     NULL (Uncategorized)
             Neural rosettes
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
    PRDM8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDM8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.373642
        Custom PCR Arrays for PRDM8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PRDM8
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    QuantiFast Probe-based Assays in human, mouse, rat PRDM8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRDM8 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdm81 , 5 PR domain containing 81, 5 84.93(n)1
    88.63(a)1
      5 (47.77 cM)5
    776301  NM_029947.21  NP_084223.21 
     981808695 
    chicken
    (Gallus gallus)
    Aves PRDM86
    PR domain containing 8
    48(a)
    1 ↔ 1
    4(44734247-44737047)
    lizard
    (Anolis carolinensis)
    Reptilia PRDM86
    PR domain containing 8
    63(a)
    1 ↔ 1
    GL343425.1(365023-386430)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia prdm81 PR domain containing 8 63.62(n)
    67.93(a)
      733976  NM_001045686.1  NP_001039151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prdm8b1 PR domain containing 8b 64.31(n)
    67.26(a)
      557162  NM_001105105.1  NP_001098575.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG132876
    --
    21(a)
    1 → many
    3L(5875404-5877190)


    ENSEMBL Gene Tree for PRDM8 (if available)
    TreeFam Gene Tree for PRDM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRDM8 gene
    ZNF4882  

    PRDM8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRDM8 (see all 505)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431621951,2
    --81104465(+) TGGAGC/GGTGTT 1 -- us2k10--------
    rs1482501491,2
    --81104529(+) GCTGTC/GTTAAG 1 -- us2k10--------
    rs38220101,2
    C,F,H--81104548(+) GTCCAG/AAAATC 1 -- us2k127Minor allele frequency- A:0.25NA EA NS WA CSA 2980
    rs38220111,2
    C,F,H--81104609(+) AGAGAG/AGAAAA 1 -- us2k1 trp313Minor allele frequency- A:0.09NS EA CSA WA 1750
    rs726565141,2
    C,F--81104643(+) AGCGGG/ATGTGT 1 -- us2k15Minor allele frequency- A:0.24WA CSA NA EA 362
    rs38220121,2
    C,F,A,H--81104644(+) GCGGGT/CGTGTG 1 -- us2k17Minor allele frequency- C:0.29NA WA CSA EA 366
    rs38220131,2
    C,F,H--81104703(+) AGGGAG/AAATGG 1 -- us2k1 trp318Minor allele frequency- A:0.26NS EA NA WA CSA 2342
    rs789253881,2
    C,F--81104730(+) GGTTGC/TCAGGA 1 -- us2k11Minor allele frequency- T:0.19WA 118
    rs1412419851,2
    --81104973(+) ACCCCC/TACCCC 1 -- us2k10--------
    rs38942611,2
    C,F,A--81104978(+) CACCCC/TCGCCC 1 -- us2k12Minor allele frequency- T:0.02MN WA 186

    HapMap Linkage Disequilibrium report for PRDM8 (81105033 - 81125483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PRDM8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29411CNV Loss19812545

    Human Gene Mutation Database (HGMD): PRDM8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDM8
    DNA2.0 Custom Variant and Variant Library Synthesis for PRDM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    7 diseases for PRDM8:    
    About MalaCards
    early-onset lafora body disease    lafora disease    progressive myoclonus epilepsy    myoclonus epilepsy
    myoclonus    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PRDM8:
    Progressive myoclonus epilepsy

    PRDM8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRDM8

    Export disorders for PRDM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRDM8 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with PRDM8)
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    1. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Early-onset Lafora body disease. (PubMed id 22961547)1 Turnbull J....Minassian B.A. (Brain 2012)
    4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    5. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. (PubMed id 21909115)4  ....Johnson T. (Nature 2011)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. SET domains and histone methylation. (PubMed id 14675547)1 Xiao B....Gamblin S.J. (Curr. Opin. Struct. Biol. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The yin-yang of PR-domain family genes in tumorigenesis. (PubMed id 10668202)1 Jiang G.L. and Huang S. (Histol. Histopathol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56978 HGNC: 13993 AceView: PRDM8 Ensembl:ENSG00000152784 euGenes: HUgn56978
    ECgene: PRDM8 H-InvDB: PRDM8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRDM8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRDM8 gene:
    Search GeneIP for patents involving PRDM8

    GeneCards and IP:
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