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Aliases for PRDM8 Gene

Aliases for PRDM8 Gene

  • PR Domain Containing 8 2 3
  • PR Domain-Containing Protein 8 3 4
  • PFM5 3 4
  • PR Domain Zinc Finger Protein 8 3
  • PR-Domain Containing Protein 8 3
  • EC 2.1.1.- 4

External Ids for PRDM8 Gene

Previous GeneCards Identifiers for PRDM8 Gene

  • GC04P080993
  • GC04P081391
  • GC04P081498
  • GC04P081564
  • GC04P081565
  • GC04P081462
  • GC04P081325
  • GC04P081107
  • GC04P076850

Summaries for PRDM8 Gene

GeneCards Summary for PRDM8 Gene

PRDM8 (PR Domain Containing 8) is a Protein Coding gene. Diseases associated with PRDM8 include early-onset lafora body disease. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K9 specific).

UniProtKB/Swiss-Prot for PRDM8 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM8 Gene

Genomics for PRDM8 Gene

Regulatory Elements for PRDM8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRDM8 Gene

Start:
80,183,879 bp from pter
End:
80,204,329 bp from pter
Size:
20,451 bases
Orientation:
Plus strand

Genomic View for PRDM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM8 Gene

Proteins for PRDM8 Gene

  • Protein details for PRDM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQV8-PRDM8_HUMAN
    Recommended name:
    PR domain zinc finger protein 8
    Protein Accession:
    Q9NQV8
    Secondary Accessions:
    • A8K7X2
    • Q6IQ36

    Protein attributes for PRDM8 Gene

    Size:
    689 amino acids
    Molecular mass:
    71663 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF87241.1; Type=Frameshift; Positions=287; Evidence={ECO:0000305};

    Alternative splice isoforms for PRDM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDM8 Gene

Proteomics data for PRDM8 Gene at MOPED

Post-translational modifications for PRDM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDM8 Gene

Antibody Products

No data available for DME Specific Peptides for PRDM8 Gene

Domains for PRDM8 Gene

Protein Domains for PRDM8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRDM8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NQV8

UniProtKB/Swiss-Prot:

PRDM8_HUMAN :
  • Q9NQV8
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PRDM8: view

No data available for Gene Families for PRDM8 Gene

Function for PRDM8 Gene

Molecular function for PRDM8 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Enzyme Numbers (IUBMB) for PRDM8 Gene

Gene Ontology (GO) - Molecular Function for PRDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding --
GO:0042054 histone methyltransferase activity --
genes like me logo Genes that share ontologies with PRDM8: view

Phenotypes for PRDM8 Gene

genes like me logo Genes that share phenotypes with PRDM8: view

Animal Model Products

miRNA for PRDM8 Gene

miRTarBase miRNAs that target PRDM8

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRDM8 Gene

Localization for PRDM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDM8 Gene COMPARTMENTS Subcellular localization image for PRDM8 gene
Compartment Confidence
nucleus 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRDM8: view

Pathways for PRDM8 Gene

SuperPathways for PRDM8 Gene

No Data Available

Interacting Proteins for PRDM8 Gene

Gene Ontology (GO) - Biological Process for PRDM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016571 histone methylation --
GO:0021540 corpus callosum morphogenesis IEA --
GO:0021952 central nervous system projection neuron axonogenesis --
GO:0021957 corticospinal tract morphogenesis IEA --
genes like me logo Genes that share ontologies with PRDM8: view

No data available for Pathways by source for PRDM8 Gene

Transcripts for PRDM8 Gene

Unigene Clusters for PRDM8 Gene

PR domain containing 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: -
SP2: - - - - - -
SP3: -
SP4: - - - - - -
SP5:
SP6: - - - - - - - -
SP7: - - - - - - -

Relevant External Links for PRDM8 Gene

GeneLoc Exon Structure for
PRDM8
ECgene alternative splicing isoforms for
PRDM8

Expression for PRDM8 Gene

mRNA expression in normal human tissues for PRDM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PRDM8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (51.7) and Retina (17.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRDM8 Gene

SOURCE GeneReport for Unigene cluster for PRDM8 Gene Hs.373642

genes like me logo Genes that share expressions with PRDM8: view

Expression partners for PRDM8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDM8 Gene

Orthologs for PRDM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDM8 35
  • 91.87 (n)
  • 95.45 (a)
PRDM8 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDM8 35
  • 89.35 (n)
  • 90.79 (a)
PRDM8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdm8 35
  • 84.93 (n)
  • 88.63 (a)
Prdm8 16
Prdm8 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRDM8 35
  • 97.93 (n)
  • 97.55 (a)
PRDM8 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdm8 35
  • 84.61 (n)
  • 87.17 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDM8 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM8 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDM8 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDM8 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm8 35
  • 63.62 (n)
  • 67.93 (a)
zebrafish
(Danio rerio)
Actinopterygii prdm8b 35
  • 64.31 (n)
  • 67.26 (a)
prdm8b 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13287 36
  • 21 (a)
OneToMany
Species with no ortholog for PRDM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDM8 Gene

ENSEMBL:
Gene Tree for PRDM8 (if available)
TreeFam:
Gene Tree for PRDM8 (if available)

Paralogs for PRDM8 Gene

No data available for Paralogs for PRDM8 Gene

Variants for PRDM8 Gene

Sequence variations from dbSNP and Humsavar for PRDM8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12780 -- 80,203,442(-) CGCCG(C/G)CGCTT synonymous-codon, reference
rs930904 -- 80,199,018(+) TTTTT(A/T)AGTGA intron-variant
rs1139248 -- 80,200,086(+) ATGGA(G/T)GATAC reference, missense
rs1458042 -- 80,191,733(+) CACCT(C/T)TTCAT intron-variant
rs1458043 -- 80,192,041(+) TCTCT(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM8 Gene

Variant ID Type Subtype PubMed ID
esv29411 CNV Loss 19812545

Relevant External Links for PRDM8 Gene

HapMap Linkage Disequilibrium report
PRDM8
Human Gene Mutation Database (HGMD)
PRDM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM8 Gene

Disorders for PRDM8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PRDM8 Gene in MalaCards »

(1) Diseases for PRDM8 Gene including...

(1) University of Copenhagen DISEASES for PRDM8 Gene

Relevant External Links for PRDM8

Genetic Association Database (GAD)
PRDM8
genes like me logo Genes that share disorders with PRDM8: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for PRDM8 Gene

Publications for PRDM8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 48
  3. Early-onset Lafora body disease. (PMID: 22961547) Turnbull J. … Minassian B.A. (Brain 2012) 3
  4. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3
  5. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 48

Products for PRDM8 Gene

Sources for PRDM8 Gene

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