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Aliases for PRDM7 Gene

Aliases for PRDM7 Gene

  • PR/SET Domain 7 2 3 5
  • PR Domain Zinc Finger Protein 7 3 4
  • PR Domain Containing 7 2 3
  • PR Domain 7 2 3
  • EC 2.1.1.43 4 61
  • PFM4 3 4
  • Probable Histone-Lysine N-Methyltransferase PRDM7 3
  • PR Domain-Containing Protein 7 4
  • PR-Domain Family Protein 4 3
  • ZNF910 3

External Ids for PRDM7 Gene

Previous GeneCards Identifiers for PRDM7 Gene

  • GC16M081443
  • GC16M091111
  • GC16M089824
  • GC16M089865
  • GC16M088650
  • GC16M090122
  • GC16M075814

Summaries for PRDM7 Gene

Entrez Gene Summary for PRDM7 Gene

  • This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]

GeneCards Summary for PRDM7 Gene

PRDM7 (PR/SET Domain 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Lysine degradation. GO annotations related to this gene include nucleic acid binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is PRDM9.

UniProtKB/Swiss-Prot for PRDM7 Gene

  • Probable histone methyltransferase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM7 Gene

Genomics for PRDM7 Gene

Regulatory Elements for PRDM7 Gene

Enhancers for PRDM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F090018 1.4 FANTOM5 ENCODE 16.4 +71.0 70967 5.3 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS DBNDD1 DEF8 PRDM7 GAS8 FAM157C ENSG00000261172 URAHP GAS8-AS1 TUBB3 ENSG00000283182
GH16F089853 0.5 FANTOM5 3.4 +238.6 238571 0.1 GABPB1 ZBTB33 MNT GAS8-AS1 DBNDD1 PRDM7 DPEP1 LOC105371419 SPIRE2
GH16F090076 1.6 FANTOM5 Ensembl ENCODE 0.4 +14.2 14226 1.9 ATF1 PKNOX1 ZNF2 GLIS2 ZNF143 FOS SP3 SP5 NFYC MBD2 CDK10 ENSG00000261172 SPATA2L ZNF276 TCF25 VPS9D1 SPATA33 PRDM7 URAHP
GH16F090081 1.3 Ensembl ENCODE 0.4 +9.7 9696 1.6 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 DEK ZNF263 SP3 SP5 ENSG00000261172 FAM157C DEF8 CDK10 ENSG00000259877 TUBB8P7 FANCA PRDM7 URAHP
GH16F090057 1.1 Ensembl ENCODE 0.3 +34.2 34195 1.0 HDAC1 ZBTB40 CREM EGR2 ZBTB11 CEBPB ELF1 SMARCA4 ETV4 CEBPA ENSG00000261172 URAHP PRDM7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRDM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRDM7 Gene

Chromosome:
16
Start:
90,056,566 bp from pter
End:
90,092,072 bp from pter
Size:
35,507 bases
Orientation:
Minus strand

Genomic View for PRDM7 Gene

Genes around PRDM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM7 Gene

Proteins for PRDM7 Gene

  • Protein details for PRDM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQW5-PRDM7_HUMAN
    Recommended name:
    Probable histone-lysine N-methyltransferase PRDM7
    Protein Accession:
    Q9NQW5
    Secondary Accessions:
    • A4Q9G8
    • Q08EM4
    • Q9NQW4

    Protein attributes for PRDM7 Gene

    Size:
    492 amino acids
    Molecular mass:
    55777 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse orthologous protein seems not to exist. According to PubMed:17916234, human PRDM7 and PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human and mouse.

    Alternative splice isoforms for PRDM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDM7 Gene

Selected DME Specific Peptides for PRDM7 Gene

Q9NQW5:
  • EQNLVAFQ
  • GDEYGQELGI

Post-translational modifications for PRDM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PRDM7 Gene

Gene Families for PRDM7 Gene

Protein Domains for PRDM7 Gene

Suggested Antigen Peptide Sequences for PRDM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQW5

UniProtKB/Swiss-Prot:

PRDM7_HUMAN :
  • Contains 1 KRAB-related domain.
Domain:
  • Contains 1 KRAB-related domain.
  • Contains 1 SET domain.
genes like me logo Genes that share domains with PRDM7: view

Function for PRDM7 Gene

Molecular function for PRDM7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Probable histone methyltransferase.

Enzyme Numbers (IUBMB) for PRDM7 Gene

Gene Ontology (GO) - Molecular Function for PRDM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0018024 histone-lysine N-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PRDM7: view
genes like me logo Genes that share phenotypes with PRDM7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRDM7 Gene

Localization for PRDM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDM7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PRDM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PRDM7: view

Pathways & Interactions for PRDM7 Gene

genes like me logo Genes that share pathways with PRDM7: view

Pathways by source for PRDM7 Gene

2 Reactome pathways for PRDM7 Gene
1 KEGG pathway for PRDM7 Gene

Interacting Proteins for PRDM7 Gene

Gene Ontology (GO) - Biological Process for PRDM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0032259 methylation IEA --
GO:0034968 histone lysine methylation IEA --
genes like me logo Genes that share ontologies with PRDM7: view

No data available for SIGNOR curated interactions for PRDM7 Gene

Drugs & Compounds for PRDM7 Gene

(2) Drugs for PRDM7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with PRDM7: view

Transcripts for PRDM7 Gene

mRNA/cDNA for PRDM7 Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRDM7 Gene

PR domain containing 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM7 Gene

No ASD Table

Relevant External Links for PRDM7 Gene

GeneLoc Exon Structure for
PRDM7
ECgene alternative splicing isoforms for
PRDM7

Expression for PRDM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRDM7 Gene

mRNA differential expression in normal tissues according to GTEx for PRDM7 Gene

This gene is overexpressed in Testis (x40.9).

Protein differential expression in normal tissues from HIPED for PRDM7 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRDM7 Gene



Protein tissue co-expression partners for PRDM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDM7 Gene:

PRDM7

SOURCE GeneReport for Unigene cluster for PRDM7 Gene:

Hs.406695
genes like me logo Genes that share expression patterns with PRDM7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRDM7 Gene

Orthologs for PRDM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDM7 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDM7 35
  • 57 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDM7 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM7 35
  • 1 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PRDM7 35
  • 2 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43347 35
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-17 34
  • 46.25 (n)
Species where no ortholog for PRDM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRDM7 Gene

ENSEMBL:
Gene Tree for PRDM7 (if available)
TreeFam:
Gene Tree for PRDM7 (if available)

Paralogs for PRDM7 Gene

Paralogs for PRDM7 Gene

(3) SIMAP similar genes for PRDM7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PRDM7 Gene

genes like me logo Genes that share paralogs with PRDM7: view

Variants for PRDM7 Gene

Sequence variations from dbSNP and Humsavar for PRDM7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11076664 -- 90,056,154(+) ctgag(A/G)tgggt downstream-variant-500B
rs111293057 -- 90,078,707(+) ACACT(C/G)ACAGC upstream-variant-2KB
rs111309557 -- 90,077,942(+) GCTGT(C/G)ATCCA upstream-variant-2KB
rs111315634 -- 90,067,735(+) GCAGG(C/T)GCCTG intron-variant, upstream-variant-2KB
rs111327910 -- 90,056,385(+) CTCAG(-/A)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PRDM7 Gene

Variant ID Type Subtype PubMed ID
esv3639606 CNV gain 21293372
esv3639607 CNV gain 21293372
esv3639609 CNV loss 21293372
esv3553924 CNV deletion 23714750
esv28486 CNV loss 19812545
esv2660381 CNV deletion 23128226
esv2550224 CNV deletion 19546169
esv1938258 CNV deletion 18987734
dgv3067n100 CNV gain 25217958
nsv978180 CNV duplication 23825009
nsv9482 CNV loss 18304495
nsv573841 CNV loss 21841781
nsv514823 CNV gain 21397061
nsv509641 CNV insertion 20534489
nsv482951 CNV loss 15286789
nsv471120 CNV gain 18288195
nsv471119 CNV loss 18288195
nsv457626 CNV loss 19166990
nsv428331 CNV gain+loss 18775914
nsv1934 CNV deletion 18451855
nsv1067164 CNV gain+loss 25217958
nsv1064351 CNV gain+loss 25217958
nsv1062080 CNV loss 25217958
nsv1059965 CNV gain 25217958
esv3639612 CNV gain 21293372
esv3639611 CNV loss 21293372
esv3639610 CNV gain 21293372

Variation tolerance for PRDM7 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.05; 95.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM7 Gene

Disorders for PRDM7 Gene

Relevant External Links for PRDM7

Genetic Association Database (GAD)
PRDM7
Human Genome Epidemiology (HuGE) Navigator
PRDM7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDM7

No disorders were found for PRDM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRDM7 Gene

Publications for PRDM7 Gene

  1. Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates. (PMID: 17916234) Fumasoni I. … Ciccarelli F.D. (BMC Evol. Biol. 2007) 2 3 4 64
  2. PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase. (PMID: 27129774) Blazer L.L. … Vedadi M. (J. Biol. Chem. 2016) 2 3 64
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
  4. The yin-yang of PR-domain family genes in tumorigenesis. (PMID: 10668202) Jiang G.L. … Huang S. (Histol. Histopathol. 2000) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for PRDM7 Gene

Sources for PRDM7 Gene

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