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Aliases for PRDM7 Gene

Aliases for PRDM7 Gene

  • PR Domain Containing 7 2 3
  • PR Domain Zinc Finger Protein 7 3 4
  • EC 2.1.1.43 4 63
  • PFM4 3 4
  • Probable Histone-Lysine N-Methyltransferase PRDM7 3
  • PR Domain-Containing Protein 7 4
  • PR-Domain Family Protein 4 3
  • ZNF910 3

External Ids for PRDM7 Gene

Previous GeneCards Identifiers for PRDM7 Gene

  • GC16M081443
  • GC16M091111
  • GC16M089824
  • GC16M089865
  • GC16M088650
  • GC16M090122
  • GC16M075814

Summaries for PRDM7 Gene

Entrez Gene Summary for PRDM7 Gene

  • This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]

GeneCards Summary for PRDM7 Gene

PRDM7 (PR Domain Containing 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and histone-lysine N-methyltransferase activity. An important paralog of this gene is PRDM11.

UniProtKB/Swiss-Prot for PRDM7 Gene

  • Probable histone methyltransferase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM7 Gene

Genomics for PRDM7 Gene

Regulatory Elements for PRDM7 Gene

Genomic Location for PRDM7 Gene

Start:
90,056,566 bp from pter
End:
90,092,072 bp from pter
Size:
35,507 bases
Orientation:
Minus strand

Genomic View for PRDM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM7 Gene

Proteins for PRDM7 Gene

  • Protein details for PRDM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQW5-PRDM7_HUMAN
    Recommended name:
    Probable histone-lysine N-methyltransferase PRDM7
    Protein Accession:
    Q9NQW5
    Secondary Accessions:
    • A4Q9G8
    • Q08EM4
    • Q9NQW4

    Protein attributes for PRDM7 Gene

    Size:
    492 amino acids
    Molecular mass:
    55777 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The mouse orthologous protein seems not to exist. According to PubMed:17916234, human PRDM7 and PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human and mouse

    Alternative splice isoforms for PRDM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRDM7 Gene

Proteomics data for PRDM7 Gene at MOPED

Selected DME Specific Peptides for PRDM7 Gene

Post-translational modifications for PRDM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDM7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRDM7 Gene

Gene Families for PRDM7 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for PRDM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQW5

UniProtKB/Swiss-Prot:

PRDM7_HUMAN :
  • Q9NQW5
Domain:
  • Contains 1 KRAB-related domain.
  • Contains 1 SET domain.
genes like me logo Genes that share domains with PRDM7: view

Function for PRDM7 Gene

Molecular function for PRDM7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
UniProtKB/Swiss-Prot Function: Probable histone methyltransferase.

Enzyme Numbers (IUBMB) for PRDM7 Gene

Gene Ontology (GO) - Molecular Function for PRDM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0018024 histone-lysine N-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PRDM7: view
genes like me logo Genes that share phenotypes with PRDM7: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRDM7 Gene

Localization for PRDM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDM7 Gene COMPARTMENTS Subcellular localization image for PRDM7 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PRDM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PRDM7: view

Pathways for PRDM7 Gene

SuperPathways for PRDM7 Gene

No Data Available

Interacting Proteins for PRDM7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000396732%0d%0a9606.ENSP00000362994%0d%0a
Selected Interacting proteins: ENSP00000396732 Q9NQW5-PRDM7_HUMAN for PRDM7 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for PRDM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0034968 histone lysine methylation IEA --
genes like me logo Genes that share ontologies with PRDM7: view

No data available for Pathways by source for PRDM7 Gene

Transcripts for PRDM7 Gene

mRNA/cDNA for PRDM7 Gene

(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(8) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRDM7 Gene

PR domain containing 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRDM7
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM7 Gene

No ASD Table

Relevant External Links for PRDM7 Gene

GeneLoc Exon Structure for
PRDM7
ECgene alternative splicing isoforms for
PRDM7

Expression for PRDM7 Gene

mRNA expression in normal human tissues for PRDM7 Gene

mRNA differential expression in normal tissues according to GTEx for PRDM7 Gene

This gene is overexpressed in Testis (40.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRDM7 Gene

SOURCE GeneReport for Unigene cluster for PRDM7 Gene Hs.406695

genes like me logo Genes that share expressions with PRDM7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRDM7 Gene

Orthologs for PRDM7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDM7 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDM7 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDM7 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM7 36
  • 1 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PRDM7 36
  • 2 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43347 36
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea set-17 35
  • 46.25 (n)
  • 36.36 (a)
Species with no ortholog for PRDM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRDM7 Gene

ENSEMBL:
Gene Tree for PRDM7 (if available)
TreeFam:
Gene Tree for PRDM7 (if available)

Paralogs for PRDM7 Gene

Paralogs for PRDM7 Gene

Selected SIMAP similar genes for PRDM7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PRDM7 Gene

genes like me logo Genes that share paralogs with PRDM7: view

Variants for PRDM7 Gene

Sequence variations from dbSNP and Humsavar for PRDM7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2077426 -- 90,061,816(-) AACAT(C/G)GTTAG intron-variant
rs2078478 - 90,063,728(+) ATTCT(C/T)TCAAA missense, reference, upstream-variant-2KB
rs2078569 -- 90,078,462(+) GGCTG(C/T)ACTGT upstream-variant-2KB
rs3743815 -- 90,060,457(-) TAGAA(A/C/T)CTGCC missense, reference, intron-variant
rs3809642 -- 90,062,587(-) TTTGA(C/T)GGTAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRDM7 Gene

Variant ID Type Subtype PubMed ID
nsv428331 CNV Gain+Loss 18775914
dgv3009n71 CNV Loss 21882294
dgv3015n71 CNV Loss 21882294
nsv457626 CNV Loss 19166990
nsv471119 CNV Loss 18288195
nsv482951 CNV Loss 15286789
nsv471120 CNV Gain 18288195
dgv3016n71 CNV Loss 21882294
nsv509641 CNV Insertion 20534489
nsv1934 CNV Loss 18451855
esv2550224 CNV Deletion 19546169
nsv9482 CNV Loss 18304495
esv1938258 CNV Deletion 18987734
esv2660381 CNV Deletion 23128226
nsv514823 CNV Complex 21397061
esv28486 CNV Loss 19812545

Relevant External Links for PRDM7 Gene

HapMap Linkage Disequilibrium report
PRDM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM7 Gene

Disorders for PRDM7 Gene

Relevant External Links for PRDM7

Genetic Association Database (GAD)
PRDM7
Human Genome Epidemiology (HuGE) Navigator
PRDM7
genes like me logo Genes that share disorders with PRDM7: view

No data available for UniProtKB/Swiss-Prot for PRDM7 Gene

Publications for PRDM7 Gene

  1. Family expansion and gene rearrangements contributed to the functional specialization of PRDM genes in vertebrates. (PMID: 17916234) Fumasoni I. … Ciccarelli F.D. (BMC Evol. Biol. 2007) 2 3 4
  2. The yin-yang of PR-domain family genes in tumorigenesis. (PMID: 10668202) Jiang G.L. … Huang S. (Histol. Histopathol. 2000) 3 4
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. SET domains and histone methylation. (PMID: 14675547) Xiao B. … Gamblin S.J. (Curr. Opin. Struct. Biol. 2003) 3

Products for PRDM7 Gene

Sources for PRDM7 Gene

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