Aliases for PRDM5 Gene
External Ids for PRDM5 Gene
Previous GeneCards Identifiers for PRDM5 Gene
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDM5 Gene
PRDM5 (PR/SET Domain 5) is a Protein Coding gene. Diseases associated with PRDM5 include Brittle Cornea Syndrome 2 and Axenfeld-Rieger Syndrome. GO annotations related to this gene include sequence-specific DNA binding and transcription regulatory region DNA binding.
UniProtKB/Swiss-Prot for PRDM5 Gene
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.