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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRDM5 Gene

protein-coding GIFtS: 53
GCID: GC04M121613

PR domain containing 5

Explore 10 diseases affiliated with
PRDM5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PR Domain Containing 5¹ ²
PFM2¹ ² ³
BCS2²
PR Domain Zinc Finger Protein 5²
PR Domain-Containing Protein 5³

External Ids:	HGNC: 9349¹	Entrez Gene: 11107²	Ensembl: ENSG00000138738⁷	OMIM: 614161⁵	UniProtKB: Q9NQX1³

Export aliases for PRDM5 gene to outside databases

Previous GC identifers: GC04M122540 GC04M121895 GC04M122009 GC04M122074 GC04M121973 GC04M117343

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDM5:

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and

multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell

differentiation and tumorigenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRDM5_HUMAN, Q9NQX1

Function: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment

of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated

protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix

development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components,

such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M

arrest and apoptosis in cancer cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRDM5 gene promoter:
LHX3b/Lhx3b Pax-2 Pax-2a NF-AT NF-AT2 Pax-2b NRF-2 LHX3a/Lhx3a NF-AT1 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PRDM5 promoter sequence

Search SABiosciences Chromatin IP Primers for PRDM5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDM5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25-q26 Ensembl cytogenetic band: 4q27 HGNC cytogenetic band: 4q25-q26

PRDM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDM5 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M121613: view genomic region (about GC identifiers)

Start:	121,606,074 bp from pter	End:	121,844,025 bp from pter
Size:	237,952 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRDM5_HUMAN, Q9NQX1 (See protein sequence)

Recommended Name: PR domain zinc finger protein 5

Size: 630 amino acids; 73090 Da

Subunit: Interacts with EHMT2/G9A, GFI1 and HDAC1

Subcellular location: Nucleus

Secondary accessions: Q0VAJ0 Q6NXQ7

Alternative splicing: 3 isoforms: Q9NQX1-1 Q9NQX1-2 Q9NQX1-3

Explore the universe of human proteins at neXtProt for PRDM5: NX_Q9NQX1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQX1

PRDM5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061169.2

ENSEMBL proteins:

ENSP00000264808 ENSP00000422309 ENSP00000404832 ENSP00000424861 ENSP00000377955

Human Recombinant Protein Products for PRDM5:

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	Uscn Proteins for PRDM5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	17636019

PRDM5 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PRDM5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRDM5 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR015880 Znf_C2H2-like

IPR001214 SET_dom

IPR007087 Znf_C2H2

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR022755 Znf_C2H2_jaz

Graphical View of Domain Structure for InterPro Entry Q9NQX1

ProtoNet protein and cluster: Q9NQX1

UniProtKB/Swiss-Prot: PRDM5_HUMAN, Q9NQX1

Similarity: Contains 16 C2H2-type zinc fingers

Similarity: Contains 1 SET domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PRDM5_HUMAN, Q9NQX1

Function: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment

of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated

protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix

development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components,

such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M

arrest and apoptosis in cancer cells

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	IEA	--
GO:0005515	protein binding	IPI	17636019
GO:0008270	zinc ion binding	IEA	--
GO:0043565	sequence-specific DNA binding	IDA	17636019
GO:0044212	transcription regulatory region DNA binding	IDA	17636019

PRDM5 for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Prdm5):

skeleton

PRDM5 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PRDM5

miRNA Products:		OriGene 3'-UTR Clone: PRDM5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDM5
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDM5 (see all 9):
		hsa-miR-3934 hsa-miR-136 hsa-miR-125a-3p hsa-miR-1237 hsa-miR-764 hsa-miR-4314 hsa-miR-129-3p hsa-miR-450b-5p

		SwitchGear 3'UTR luciferase reporter plasmid: PRDM5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PRDM5

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for PRDM5 (Q9NQX1^{1, 3} ENSP00000264808⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EHMT2	Q96KQ7¹^,³, ENSP00000364687⁴	EBI-4292031,EBI-744366 I2D: score=1 STRING: ENSP00000364687
GFI1	Q99684¹^,³, ENSP00000294702⁴	EBI-4292031,EBI-949368 I2D: score=2 STRING: ENSP00000294702
HDAC1	Q13547¹^,³, ENSP00000362649⁴	EBI-4292031,EBI-301834 I2D: score=1 STRING: ENSP00000362649
POU2F1	P14859³	I2D: score=1
--	ENSP00000397323⁴	STRING: ENSP00000397323

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000278	mitotic cell cycle	IMP	17636019
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0016575	histone deacetylation	IMP	17636019
GO:0045892	negative regulation of transcription, DNA-dependent	IDA	17636019
GO:0051567	histone H3-K9 methylation	IDA	17636019

PRDM5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRDM5
Search CenterWatch for drugs/clinical trials and news about PRDM5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRDM5 gene:

NM_018699.2

Unigene Clusters for PRDM5:

PR domain containing 5

Hs.666782 [show with all ESTs], Hs.669312 [show with all ESTs]

Unigene Representative Sequences: NM_018699, BC030136

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000513741 ENST00000264808(uc003idn.3 uc003ido.3 uc010ine.3)

ENST00000515109 ENST00000428209 ENST00000505484 ENST00000506065 ENST00000503661

ENST00000502409 ENST00000512845(uc010inf.3) ENST00000507611 ENST00000394435(uc003idp.1)

ENST00000505033

miRNA Products:		OriGene 3'-UTR Clone: PRDM5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDM5
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDM5 (see all 9):
		hsa-miR-3934 hsa-miR-136 hsa-miR-125a-3p hsa-miR-1237 hsa-miR-764 hsa-miR-4314 hsa-miR-129-3p hsa-miR-450b-5p

		SwitchGear 3'UTR luciferase reporter plasmid: PRDM5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PRDM5

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		GenScript: all cDNA clones in your preferred vector: PRDM5 (NM_018699)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRDM5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRDM5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRDM5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDM5

Additional cDNA sequence: BC030136.2

10 DOTS entries:

DT.303732 DT.75161413 DT.121228895 DT.75125435 DT.121228891 DT.100681756 DT.101966241 DT.40296482

DT.97832230 DT.40129404

24/32 AceView cDNA sequences (see all 32):

CB852042 AA424447 NM_018699 BX498792 AI810960 AI521783 CA394675 AL710704

CD300170 AK056352 AA884744 BQ899370 BX504031 AI684820 BG717199 AV710759

BX646150 BX955944 AA917968 BX504012 BC066942 BX498497 AF272897 BM563688

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRDM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAGCATTT

About this image

PRDM5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PRDM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRDM5

SOURCE GeneReport for Unigene clusters: Hs.666782 Hs.669312

UniProtKB/Swiss-Prot: PRDM5_HUMAN, Q9NQX1

Tissue specificity: Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast,

colorectal, gastric and liver cancer tissues

SABiosciences Custom PCR Arrays for PRDM5

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDM5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PRDM5 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Prdm5^{1 , 5}	PR domain containing 5^{1, 5}	87.76(n)¹ 92.65(a)¹		6 (30.32 cM)⁵ 70779¹ NM_027547.2¹ NP_081823.2¹ 65778988⁵
chicken (Gallus gallus)	Aves	PRDM5¹	PR domain containing 5	81.69(n) 85.71(a)		422673 XM_420628.3 XP_420628.3
lizard (Anolis carolinensis)	Reptilia	PRDM5⁶	--	80(a)	1 ↔ 1	5(139479989-139576718)
zebrafish (Danio rerio)	Actinopterygii	prdm5¹	PR domain containing 5	70.29(n) 78.59(a)		432371 NM_001002301.1 NP_001002301.1

ENSEMBL Gene Tree for PRDM5 (if available)
TreeFam Gene Tree for PRDM5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141491796^1,2	C	unknown	117536786(+)	`GTATAC/GGGACA`	1	--	int¹		0	--	--	--	--
rs76338159^1,2	F	--	117342789(+)	`AATATC/ATATTT`	1	--	ds500¹		1		WA	118
rs77157999^1,2	C,F	--	117343268(+)	`GGCAAA/GTAAGA`	1	--	ut3¹		1		NA	120
rs7674078^1,2	A	--	117343815(+)	`CTTTAC/TGGTCT`	1	--	int¹		0	--	--	--	--
rs78732146^1,2	F	--	117344439(+)	`AGAAGG/CGGGTA`	1	--	int¹		1		WA	118
rs77411783^1,2		--	117344657(+)	`CTACTC/ATCTTG`	1	--	int¹		2		CSA WA	120
rs79283335^1,2		--	117345311(+)	`TGCAAC/TAGCAT`	1	--	int¹		1		WA	118
rs76269120^1,2	F	--	117345790(+)	`ATATTA/TATCTT`	1	--	int¹		1		WA	118
rs34954999^1,2	C,F	--	117345848(+)	`GGCATT/-AATCT`	1	--	int¹		3		NA	6
rs36062454^1,2	C,F	--	117346928(+)	`TGTCTT/CTCAAA`	1	--	int¹		7		NA CSA WA EA	366

HapMap Linkage Disequilibrium report for PRDM5 (121606074 - 121844025 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PRDM5
1 CNV: 98868
2 Indels: 46500 12544
Human Gene Mutation Database (HGMD): PRDM5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRDM5

DNA2.0 Custom Variant and Variant Library Synthesis for PRDM5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRDM5 for disorders About GeneDecksing

OMIM gene information: 614161 OMIM disorders: --

UniProtKB/Swiss-Prot: PRDM5_HUMAN, Q9NQX1

Defects in PRDM5 are the cause of Brittle cornea syndrome type 2 (BCS2) [MIM:614170]. A disorder characterized

by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or

keratoglobus, hyperelasticity of the skin, and hypermobile joints

10 diseases for PRDM5: About MalaCards

type vi ehlers-danlos syndrome ehlers-danlos syndrome alcohol dependence keratoconus

myopia liver cancer hematopoiesis alcoholism

gastric cancer cervicitis

1 disease from the University of Copenhagen DISEASES database for PRDM5:

Ehlers-Danlos syndrome

Human Genome Epidemiology (HuGE) Navigator: PRDM5 (2 documents)

Export disorders for PRDM5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRDM5 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with PRDM5)

Utopia: connect your pdf to the dynamic
world of online information

PRDM5 is silenced in human cancers and has growth suppressive activities. (PubMed id 15077163)^{1, 2, 9} Deng Q. and Huang S. (2004)
Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance. (PubMed id 21664999)^{1, 2} Burkitt Wright E.M....Black G.C. (2011)
Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5. (PubMed id 17636019)^{1, 2} Duan Z....Horwitz M.S. (2007)
PRDM5 identified as a target of epigenetic silencing in colorectal and gastric cancer. (PubMed id 17699856)^{1, 2} Watanabe Y....Tokino T. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The epigenetic modifier PRDM5 functions as a tumor sup pressor through modulating WNT/b-catenin signaling and is frequently silenced in multiple tumors. (PubMed id 22087297)¹ Shu X.S....Tao Q. (2011)
Genome-wide association study identifies genetic vari ants influencing F-cell levels in sickle-cell patients. (PubMed id 21326311)¹ Bhatnagar P....Keefer J.R. (2011)
A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)¹ Kalsi G....Riley B.P. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
DNA methylation and carcinogenesis of PRDM5 in cervic al cancer. (PubMed id 20213097)¹ Cheng H.Y....Lou G. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11107	HGNC: 9349	AceView: PRDM5	Ensembl:ENSG00000138738	euGenes: HUgn11107
ECgene: PRDM5	H-InvDB: PRDM5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PRDM5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRDM5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRDM5 gene
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