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PRDM4 Gene

protein-coding   GIFtS: 59
GCID: GC12M108126

PR Domain Containing 4

  Search for PRDM4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PR Domain Containing 41 2
PFM12 3 5
PR Domain-Containing Protein 42 3
PR Domain Zinc Finger Protein 42
PR-Domain Zinc-Finger Protein PFM12
EC 2.1.1.-3

External Ids:    HGNC: 93481   Entrez Gene: 111082   Ensembl: ENSG000001108517   OMIM: 6057805   UniProtKB: Q9UKN53   

Export aliases for PRDM4 gene to outside databases

Previous GC identifers: GC12M107237 GC12M108007 GC12M106629 GC12M105186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRDM4 Gene:
The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a
PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved
in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12
cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that
is thought to contain tumor suppressor genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRDM4 Gene:
PRDM4 (PR domain containing 4) is a protein-coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM6.

UniProtKB/Swiss-Prot: PRDM4_HUMAN, Q9UKN5
Function: May function as a transcription factor involved in cell differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRDM4 gene promoter:
         FOXF2   AML1a   C/EBPalpha   Roaz   POU2F1   FOXC1   POU2F1a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRDM4 promoter sequence
   Search Chromatin IP Primers for PRDM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRDM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24.1   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23-q24.1

PRDM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDM4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M108126:  view genomic region     (about GC identifiers)

Start:
108,126,643 bp from pter      End:
108,155,049 bp from pter
Size:
28,407 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRDM4_HUMAN, Q9UKN5 (See protein sequence)
Recommended Name: PR domain zinc finger protein 4  
Size: 801 amino acids; 87920 Da
2 PDB 3D structures from and Proteopedia for PRDM4:
2L9Z (3D)        3DB5 (3D)    
Secondary accessions: Q9UFA6

Explore the universe of human proteins at neXtProt for PRDM4: NX_Q9UKN5

Explore proteomics data for PRDM4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys412
  • Modification sites at PhosphoSitePlus

  • See PRDM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036538.3  
    ENSEMBL proteins: 
     ENSP00000228437   ENSP00000446803   ENSP00000449295   ENSP00000448684  
    Reactome Protein details: Q9UKN5

    PRDM4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PRDM4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR001214 SET_dom
     IPR017124 Znf_PRDM4
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UKN5

    ProtoNet protein and cluster: Q9UKN5

    UniProtKB/Swiss-Prot: PRDM4_HUMAN, Q9UKN5
    Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily
    Similarity: Contains 6 C2H2-type zinc fingers
    Similarity: Contains 1 SET domain


    Find genes that share domains with PRDM4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRDM4_HUMAN, Q9UKN5
    Function: May function as a transcription factor involved in cell differentiation

         Genatlas biochemistry entry for PRDM4:
    PR domain containing 4,widely expressed,involved in cell differentiation control and in tumorigenesis

         Enzyme Number (IUBMB): EC 2.1.1.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008168methyltransferase activity IEA--
    GO:0008270zinc ion binding TAS10552934
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with PRDM4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PRDM4:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Prdm4):
     no phenotypic analysis  normal 

    Find genes that share phenotypes with PRDM4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRDM4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRDM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRDM4
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    miRNA
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    miRTarBase miRNAs that target PRDM4:
    hsa-let-7b-5p (MIRT052284), hsa-mir-98-5p (MIRT027471), hsa-mir-16-5p (MIRT031524), hsa-mir-103a-3p (MIRT027024), hsa-mir-192-5p (MIRT026161), hsa-mir-215-5p (MIRT024430)

    Block miRNA regulation of human, mouse, rat PRDM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRDM4 (see all 56):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-1224-3p hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmidPRDM4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRDM4

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    Addgene plasmids for PRDM4 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRDM4_HUMAN, Q9UKN5: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with PRDM4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRDM4 About    
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    p75NTR negatively regulates cell cycle via SC10.00
    2Signaling by FGFR
    Signalling by NGF0.71
    3Signaling by GPCR
    Signal Transduction0.58
    4Development HGF signaling pathway
    Neurotrophin signaling pathway0.36
    5p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling


    Find genes that share SuperPaths with PRDM4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for PRDM4
        p75(NTR)-mediated signaling

    1 Reactome Pathway for PRDM4
        p75NTR negatively regulates cell cycle via SC1


    1 Kegg Pathway  (Kegg details for PRDM4):
        Neurotrophin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRDM4
    Interactions:

        Search GeneGlobe Interaction Network for PRDM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for PRDM4 (Q9UKN52, 3 ENSP000002284374) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840222, 3MINT-61731 I2D: score=3 
    EMX1Q047413, ENSP000002581064I2D: score=1 STRING: ENSP00000258106
    SERTAD1Q9UHV23, ENSP000003506334I2D: score=1 STRING: ENSP00000350633
    FAM46CQ5VWP23I2D: score=1 
    NGFENSP000003585254STRING: ENSP00000358525
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS10552934
    GO:0007165signal transduction TAS10552934
    GO:0008283cell proliferation TAS10552934
    GO:0045786negative regulation of cell cycle TAS--

    Find genes that share ontologies with PRDM4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRDM4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRDM4 gene: 
    NM_012406.3  

    Unigene Cluster for PRDM4:

    PR domain containing 4
    Hs.506655  [show with all ESTs]
    Unigene Representative Sequence: NM_012406
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228437(uc001tmp.3 uc001tmq.3) ENST00000550376 ENST00000549416
    ENST00000550659 ENST00000547268 ENST00000547188
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRDM4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRDM4 (see all 56):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-1224-3p hsa-miR-503
    SwitchGear 3'UTR luciferase reporter plasmidPRDM4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRDM4
      QuantiFast Probe-based Assays in human, mouse, rat PRDM4

    Additional mRNA sequence: 

    AF144757.2 AK056378.1 AL133083.1 BC035581.1 BC068562.1 

    10 DOTS entries:

    DT.116156  DT.95376015  DT.101967915  DT.411174  DT.100704123  DT.99995855  DT.95264757  DT.92423910 
    DT.121190187  DT.444633 

    Selected AceView cDNA sequences (see all 188):

    AA564783 BG519545 CA424355 BM511650 BF062153 AI539641 BG421281 AA449812 
    BM800426 F10165 AW593459 AA361846 AA259147 NM_012406 AI274279 BP363107 
    AA843306 AA361586 AI261310 BX280353 AK056378 AL133083 BQ014937 AW026199 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PRDM4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
    SP1:              -                                                     -                                                   
    SP2:        -     -                                         -           -                             -                     
    SP3:                                                                                                                        
    SP4:                                                                                                                        


    ECgene alternative splicing isoforms for PRDM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRDM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTCCTGCT
    PRDM4 Expression
    About this image

    PRDM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRDM4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506655

    UniProtKB/Swiss-Prot: PRDM4_HUMAN, Q9UKN5
    Tissue specificity: Expressed in many tissues. Highly expressed in ovary, testis, pancreas, brain, heart and
    prostate

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRDM4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prdm41 , 5 PR domain containing 41, 5 90.79(n)1
    94.47(a)1
      10 (41.75 cM)5
    728431  NM_181650.21  NP_857633.21 
     858919705 
    chicken
    (Gallus gallus)
    Aves PRDM41 PR domain containing 4 80.64(n)
    86.61(a)
      418065  XM_416301.4  XP_416301.4 
    lizard
    (Anolis carolinensis)
    Reptilia PRDM46
    PR domain containing 4
    81(a)
    1 ↔ 1
    5(19840379-19859324)
    African clawed frog
    (Xenopus laevis)
    Amphibia prdm4-prov2 PR domain containing 4 74.34(n)    BC043864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prdm41 PR domain containing 4 64.35(n)
    66.57(a)
      100000537  NM_001122743.1  NP_001116215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG433476
    --
    6(a)
    1 → many
    X(10496674-10514223)


    ENSEMBL Gene Tree for PRDM4 (if available)
    TreeFam Gene Tree for PRDM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRDM4 gene
    PRDM62  PRDM122  PRDM142  PRDM72  PRDM112  
    18 SIMAP similar genes for PRDM4 using alignment to 5 protein entries:     PRDM4_HUMAN (see all proteins):
    ZNF808    ZNF72    ZNF298    ZNF585B    ZNF702P    PRDM15
    ZNF660    ZNF697    ZNF844    ZNF32    ZNF833P    ZNF80
    CTCFL    ZNF137P    ZNF664    PLZF    ZNF323    ZNF501

    Find genes that share paralogs with PRDM4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRDM4 (see all 709)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71378541,2
    C,F,A--108126209(+) AGCTTA/GGAGTC 1 -- ds50019Minor allele frequency- G:0.27NA CSA EA 373
    rs1146000561,2
    F--108126229(+) GTGGTT/ATCCTG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1821478841,2
    --108126244(+) TGGGGA/GAACCA 1 -- ds50010--------
    rs1487294881,2
    --108126258(+) AGCTGA/GATGCC 1 -- ds50010--------
    rs781127971,2
    --108126343(+) AGCAGC/TCAACC 1 -- ds50010--------
    rs118346581,2
    C,F,H--108126437(+) TTAGGC/AAGGAA 1 -- ds50018Minor allele frequency- A:0.10NS EA NA WA 516
    rs37417881,2
    C,F,A,H--108126443(+) AGGAAC/GAGGGC 1 -- ds500111Minor allele frequency- G:0.16EA NS NA CSA 1291
    rs1888854491,2
    --108126606(+) TCACTC/TATCTC 1 -- ds50010--------
    rs1513345981,2
    C--108126648(+) TCCTGC/TATTTT 1 -- ut310--------
    rs1932246431,2
    --108126676(+) ATCCTA/TCCTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PRDM4 (108126643 - 108155049 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRDM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820093CNV Loss19587683
    nsv899509CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRDM4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605780    OMIM disorders: --


    Find genes that share disorders with PRDM4           About GenesLikeMe

    Genetic Association Database (GAD): PRDM4
    Human Genome Epidemiology (HuGE) Navigator: PRDM4 (1 document)

    Export disorders for PRDM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRDM4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with PRDM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1. (PubMed id 10552934)1, 2, 3, 9 Yang X.-H. and Huang S. (Genomics 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. The PR/SET domain in PRDM4 is preceded by a zinc knuckle. (PubMed id 21604305)1 BriknarovA! K....Ness T.E. (Proteins 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11108 HGNC: 9348 AceView: PRDM4 Ensembl:ENSG00000110851 euGenes: HUgn11108
    ECgene: PRDM4 Kegg: 11108 H-InvDB: PRDM4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRDM4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRDM4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRDM4 gene:
    Search GeneIP for patents involving PRDM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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