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Aliases for PRDM4 Gene

Aliases for PRDM4 Gene

  • PR Domain Containing 4 2 3
  • PFM1 3 4 6
  • PR Domain-Containing Protein 4 3 4
  • PR-Domain Zinc-Finger Protein PFM1 3
  • PR Domain Zinc Finger Protein 4 3
  • EC 2.1.1.- 4

External Ids for PRDM4 Gene

Previous GeneCards Identifiers for PRDM4 Gene

  • GC12M107237
  • GC12M108007
  • GC12M106629
  • GC12M108126
  • GC12M105186

Summaries for PRDM4 Gene

Entrez Gene Summary for PRDM4 Gene

  • The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDM4 Gene

PRDM4 (PR Domain Containing 4) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM11.

UniProtKB/Swiss-Prot for PRDM4 Gene

  • May function as a transcription factor involved in cell differentiation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM4 Gene

Genomics for PRDM4 Gene

Regulatory Elements for PRDM4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRDM4 Gene

Start:
107,732,866 bp from pter
End:
107,761,272 bp from pter
Size:
28,407 bases
Orientation:
Minus strand

Genomic View for PRDM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM4 Gene

Proteins for PRDM4 Gene

  • Protein details for PRDM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKN5-PRDM4_HUMAN
    Recommended name:
    PR domain zinc finger protein 4
    Protein Accession:
    Q9UKN5
    Secondary Accessions:
    • Q9UFA6

    Protein attributes for PRDM4 Gene

    Size:
    801 amino acids
    Molecular mass:
    87920 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRDM4 Gene

neXtProt entry for PRDM4 Gene

Proteomics data for PRDM4 Gene at MOPED

Post-translational modifications for PRDM4 Gene

  • Ubiquitination at Lys412
  • Modification sites at PhosphoSitePlus

Other Protein References for PRDM4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PRDM4 Gene

Domains for PRDM4 Gene

Gene Families for PRDM4 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for PRDM4 Gene

Suggested Antigen Peptide Sequences for PRDM4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKN5

UniProtKB/Swiss-Prot:

PRDM4_HUMAN :
  • Q9UKN5
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PRDM4: view

Function for PRDM4 Gene

Molecular function for PRDM4 Gene

GENATLAS Biochemistry:
PR domain containing 4,widely expressed,involved in cell differentiation control and in tumorigenesis
UniProtKB/Swiss-Prot Function:
May function as a transcription factor involved in cell differentiation

Enzyme Numbers (IUBMB) for PRDM4 Gene

Gene Ontology (GO) - Molecular Function for PRDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding TAS 10552934
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with PRDM4: view

Phenotypes for PRDM4 Gene

MGI mutant phenotypes for PRDM4:
inferred from 3 alleles
GenomeRNAi human phenotypes for PRDM4:
genes like me logo Genes that share phenotypes with PRDM4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRDM4 Gene

Localization for PRDM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDM4 Gene COMPARTMENTS Subcellular localization image for PRDM4 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for PRDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRDM4: view

Pathways for PRDM4 Gene

genes like me logo Genes that share pathways with PRDM4: view

Pathways by source for PRDM4 Gene

Gene Ontology (GO) - Biological Process for PRDM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10552934
GO:0007165 signal transduction TAS 10552934
GO:0008283 cell proliferation TAS 10552934
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with PRDM4: view

Transcripts for PRDM4 Gene

Unigene Clusters for PRDM4 Gene

PR domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - - - -
SP3:
SP4:

Relevant External Links for PRDM4 Gene

GeneLoc Exon Structure for
PRDM4
ECgene alternative splicing isoforms for
PRDM4

Expression for PRDM4 Gene

mRNA expression in normal human tissues for PRDM4 Gene

SOURCE GeneReport for Unigene cluster for PRDM4 Gene Hs.506655

mRNA Expression by UniProt/SwissProt for PRDM4 Gene

Q9UKN5-PRDM4_HUMAN
Tissue specificity: Expressed in many tissues. Highly expressed in ovary, testis, pancreas, brain, heart and prostate
genes like me logo Genes that share expressions with PRDM4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for PRDM4 Gene

Orthologs for PRDM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDM4 35
  • 93.8 (n)
  • 97.25 (a)
PRDM4 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDM4 35
  • 94.84 (n)
  • 97.38 (a)
PRDM4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdm4 35
  • 90.79 (n)
  • 94.47 (a)
Prdm4 16
Prdm4 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRDM4 35
  • 99.63 (n)
  • 99.75 (a)
PRDM4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdm4 35
  • 89.46 (n)
  • 93.73 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDM4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDM4 35
  • 80.64 (n)
  • 86.61 (a)
PRDM4 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDM4 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm4 35
  • 70.38 (n)
  • 75.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia prdm4-prov 35
zebrafish
(Danio rerio)
Actinopterygii prdm4 35
  • 64.35 (n)
  • 66.57 (a)
prdm4 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43347 36
  • 6 (a)
OneToMany
Species with no ortholog for PRDM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDM4 Gene

ENSEMBL:
Gene Tree for PRDM4 (if available)
TreeFam:
Gene Tree for PRDM4 (if available)

Paralogs for PRDM4 Gene

Paralogs for PRDM4 Gene

genes like me logo Genes that share paralogs with PRDM4: view

Variants for PRDM4 Gene

Sequence variations from dbSNP and Humsavar for PRDM4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1045739 -- 107,734,001(-) GTCCT(A/G)TTTTA utr-variant-3-prime
rs1045741 -- 107,733,496(-) ACCTG(C/G)TTATT utr-variant-3-prime
rs1045749 -- 107,733,077(-) CTCCC(A/G)TGCAC utr-variant-3-prime
rs3741788 -- 107,732,666(+) AGGAA(C/G)AGGGC downstream-variant-500B
rs4015237 -- 107,762,679(+) TGCAC(G/T)CCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRDM4 Gene

Variant ID Type Subtype PubMed ID
nsv899509 CNV Gain 21882294
nsv820093 CNV Loss 19587683

Relevant External Links for PRDM4 Gene

HapMap Linkage Disequilibrium report
PRDM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM4 Gene

Disorders for PRDM4 Gene

Relevant External Links for PRDM4

Genetic Association Database (GAD)
PRDM4
Human Genome Epidemiology (HuGE) Navigator
PRDM4

No disorders were found for PRDM4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PRDM4 Gene

Publications for PRDM4 Gene

  1. PFM1 (PRDM4), a new member of the PR-domain family, maps to a tumor suppressor locus on human chromosome 12q23-q24.1. (PMID: 10552934) Yang X.-H. … Huang S. (Genomics 1999) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for PRDM4 Gene

  • Addgene plasmids for PRDM4

Sources for PRDM4 Gene

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