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PRDM2 Gene

protein-coding GIFtS: 62

GC01P013899

PR domain containing 2, with ZNF domain
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.1.1.43 ^³
HUMHOXY1 ^¹, ²
KMT8 ^¹, ², ³
MTB-ZF ^¹, ², ³
OTTHUMP00000009642 ^²
OTTHUMP00000009687 ^²
RIZ ^¹, ², ³, ⁵
RIZ1 ^¹, ²
RIZ2 ^¹, ²

Descriptions
GATA-3 binding protein G3B ^²
GATA-3-binding protein G3B ^³
Lysine N-methyltransferase 8 ^³
MTE-binding protein ^², ³
PR domain containing 2, with ZNF domain ^²
PR domain-containing protein 2 ^³
Retinoblastoma protein-interacting zinc finger protein ^², ³
Zinc finger protein RIZ ^³
retinoblastoma protein-binding zinc finger protein ^²
zinc-finger DNA-binding protein ^²

External Ids
HGNC: 9347¹
Entrez Gene: 7799²
UniProtKB: Q13029³
Ensembl: ENSG00000116731⁷

Search outside databases for aliases for PRDM2 gene

Previous GC identifers: GC01P013428 GC01P013210 GC01P013394 GC01P013776

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PRDM2:

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily.

It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and

the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this

protein have not been fully characterized, it may (1) play a role in transcriptional regulation

during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional

activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action.

Multiple transcript variants encoding different isoforms have been found for this gene. [provided

by RefSeq]

UniProtKB/Swiss-Prot: PRDM2_HUMAN, Q13029

Function: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates

'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the

macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act

as a transcriptional activator of this gene

Gene Wiki entry for PRDM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PRDM2 gene

Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36

PRDM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P013899: (about GC identifiers)

Start:	13,899,322 bp from pter
End:	14,024,162 bp from pter
Size:	124,841 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004873.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PRDM2_HUMAN, Q13029 (See protein sequence)

Recommended Name: PR domain zinc finger protein 2

Size: 1718 amino acids; 188915 Da

Subunit: Binds to the retinoblastoma protein (RB). Interacts with GATA3

Subcellular location: Nucleus

PDB structure from and Proteopedia :

2JV0 (3D)

2QPW (3D)

Secondary accessions: Q13149 Q14550 Q5VUL9

Alternative splicing, Alternative initiation: 3 isoforms: Q13029-1 Q13029-2 Q13029-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001007258.1 NP_001129082.1 NP_036363.2 NP_056950.2

ENSEMBL proteins:

ENSP00000383603 ENSP00000341621 ENSP00000383604 ENSP00000384430 ENSP00000383605 ENSP00000383606

ENSP00000312352 ENSP00000235372 ENSP00000365216

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KMT8/Riz1/Riz2, RIZ1)
	Human Recombinant Proteins from Abnova (PRDM2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	NAS	7538672 7590293
GO:0005794	Golgi apparatus	IDA	18029348

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Antibodies for PRDM2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PRDM2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KMT8/Riz1/Riz2, RIZ1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PRDM2)
	Novus Biologicals Antibodies for PRDM2

Assays for PRDM2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13029

ProtoNet protein and cluster: Q13029

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: PRDM2_HUMAN, Q13029

Similarity: Contains 8 C2H2-type zinc fingers

Similarity: Contains 1 SET domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PRDM2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PRDM2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_015866

Applied Biosystems Silencer® siRNAs for PRDM2

Sigma-Aldrich siRNA for PRDM2

Sigma-Aldrich shRNA for PRDM2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001007257
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001007257
untagged cDNA clones in CMV expression vector (see all 4): NM_001007257

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012231

UniProtKB/Swiss-Prot: PRDM2_HUMAN, Q13029

Function: S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates

'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the

macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act

as a transcriptional activator of this gene

Catalytic activity: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine +

histone N(6)-methyl-L-lysine

Enzyme Number (IUBMB): EC 2.1.1.43

Genatlas biochemistry entry for PRDM2:

PR domain containing 2,retinoblastoma RB1 protein interacting zinc finger RIZ,with two alternative

spliced forms,280kDa (RIZ1),250kDa (RIZ2),acting as a putative tumor suppressor,with RIZ1 commonly

underexpressed in breast cancer and other carcinomas

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Prdm2):

life span-post-weaning/aging

tumorigenesis

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	7590293 8654390
GO:0008168	methyltransferase activity	IEA	--
GO:0008270	zinc ion binding	NAS	7538672
GO:0016740	transferase activity	IEA	--
GO:0018024	histone-lysine N-methyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for PRDM2

5/12 Interacting proteins for PRDM2 (ENSP00000235372³) via UniProtKB, MINT, and/or STRING (see all 12 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ESR1	ENSP00000206249³	STRING (score=.969)
RB1	ENSP00000267163³	STRING (score=.89)
EP300	ENSP00000263253³	STRING (score=.854)
MGMT	ENSP00000302111³	STRING (score=.732)
RASSF1	ENSP00000352323³	STRING (score=.732)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	7590293 8654390

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PRDM2
9 Novoseek chemical compound relationships for PRDM2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	79.09	99	10405178 (3), 11135439 (2), 7969165 (2), 12002276 (2) (see all 67)
12-o-tetradecanoylphorbol 13-acetate	24.52	3	11591891 (2)
lysine	14.07	1	8464881 (1)
nad+	9.73	1	7761396 (1)
estradiol	8.24	4	16356493 (3)
steroid	0.00	1	15579774 (1)
copper	0.00	1	1638046 (1)
threonine	0.00	1	8464881 (1)
leucine	0.00	1	8654390 (1)

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2 PharmGKB drug compound relationships for PRDM2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PRDM2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PRDM2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_015866

Sigma-Aldrich siRNA for PRDM2

Sigma-Aldrich shRNA for PRDM2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001007257 NM_001135610 NM_012231 NM_015866

REFSEQ mRNAs for PRDM2 gene (4 alternative transcripts):

NM_001007257.2 NM_001135610.1 NM_012231.4 NM_015866.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001007257 NM_001135610 NM_012231 NM_015866

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001007257
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001007257
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001007257

Additional cDNA sequence:

AB208877.1 AK293725.1 AK300441.1 AK307377.1 AK308135.1 AK311678.1 BC014468.1 BC032768.1

BC140012.1 BX647310.1 CR612351.1 D45132.1 U17838.1 U23736.1

14 DOTS entries:

DT.448161 DT.86844161 DT.99984310 DT.86846472 DT.100651847 DT.92459573 DT.100780195 DT.70105016

DT.121383012 DT.40272013 DT.91986350 DT.91757460 DT.121382923 DT.91723557

24/230 AceView cDNA sequences (see all 230 ):

BU621515 BM698093 BC014468 D45132 BU753912 AA723324 AI446397 AK123605

CD722337 AI554696 NM_015866 BX113285 AU140221 BQ027300 BM693616 BM669202

AI095847 BQ576099 BF224316 AW627918 AI080707 AI500424 AA858349 AA961642

highest scoring ESTs for PRDM2:

U17838 AA310789 AA707087 AA813811 AI022686 AI032743 AI076107 AI500424 AI554696 AI702263

Unigene Cluster for PRDM2:

PR domain containing 2, with ZNF domain

Hs.371823 [show with all ESTs]

Unigene Representative Sequence: NM_012231

GeneLoc Exon Structure

9 Ensembl transcripts including schematic representations:

ENST00000400800 ENST00000343137 ENST00000400801 ENST00000407521 ENST00000400802 ENST00000400803

ENST00000311066 ENST00000235372 ENST00000376048

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PRDM2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PRDM2

¹ / ² / ³

12 probe-sets matching PRDM2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
315_at²^{, 3}	U95-A	1	1.00	1.00	0.25	1.13	D45132	0.80	1.00	0.91	1
33922_at²^{, 3}	U95-A	1	1.00	1.00	0.73	1.07	U17838	1.00	1.00	1.00	1
316_g_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.81	D45132	0.80	1.00	0.91	1
33923_s_at²^{, 3}	U95-A	1	1.00	1.00	0.24	0.24	U23736	0.80	1.00	0.91	1
205277_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012231	0.60	1.00	0.82	1
203057_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AV724783	0.60	1.00	0.82	1
216433_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U23736	0.80	1.00	0.91	1
203056_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI681013	0.40	1.00	0.76	1
205277_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203057_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216433_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203056_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PRDM2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGAAGAGAAT

SOURCE GeneReport for Unigene cluster: Hs.371823
Expression variation in blood from EXPOLDB for PRDM2
UniProtKB/Swiss-Prot: PRDM2_HUMAN, Q13029
Tissue specificity: Highly expressed in retinoblastoma cell lines and in brain tumors. Also
expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen.
Isoform 1 is expressed in testis at much higher level than isoform 3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PRDM2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Prdm2¹	--	PR domain containing 2, with ZNF domain	83.28(n) 85.26(a)	313678 XM_233620.4 XP_233620.3
mouse (Mus musculus)	Prdm2^{1, 5}	4 (74.00 cM)⁵	PR domain containing 2, with ZNF domain^{1, 5}	83.45(n)¹ 85.08(a)¹	110593¹ NM_001081355.1¹ NP_001074824.1¹ AA414336⁵ AI850024⁵ (see all 25)
zebrafish (Danio rerio)	wu:fc49e10¹	--	wu:fc49e10	54.67(n) 49.39(a)	561199 XM_684606.3 XP_689698.3
African clawed frog (Xenopus laevis)	Xl.19643²	--	Xenopus laevis transcribed sequence with moderate similarity more	79.75(n)	BJ039540.1
tropical clawed frog (Silurana tropicalis)	Str.11503²	--	Transcribed sequence with weak similarity to protein more	77.91(n)	BX691205.1

About this table Species with no ortholog for PRDM2

ENSEMBL Gene Tree for PRDM2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PRDM2 gene

PRDM1² ZNF683²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/490 NCBI SNPs in PRDM2 are shown (see all 490 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 261)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2495061^1,2	A,C,F,H,O	13904319(-)	`CCGATG/CAAAAA`	2	--	ut5¹		16	EA NA EU WA	2684
	rs979932^1,2	A,C,F,H,O	13987558(-)	`ACCCCA/GGCAAT`	3	--	ng3¹ int¹		8	EA NA WA	2094
	rs1046333^1,2	A,C,F,H	14022431(+)	`CCCGAA/TCCCCG`	2	--	ut3¹ ese³		6	MN EU EA WA	770
	rs2697962^1,2	A,C,F,H	14023579(-)	`ATCCCG/ATACTG`	2	--	ut3¹		6	EA EU WA	2072
	rs2744679^1,2	A,C,F,H	14024257(-)	`CCCGTC/TGCTGG`	1	--	ng3¹		8	EU EA WA	816
	rs2697965^1,2	A,C,F,H	14023092(-)	`TTCCCG/AATTTG`	2	--	ut3¹		4	EU EA WA	378
--	rs2697964^1,2	A,C,F,H	14023296(-)	`CCTGGA/GGTCTG`	2	--	ut3¹ ese³		4	EU EA WA	412
	rs2697967^1,2	A,C,F,H	14022619(-)	`CCAAAA/GTCCCC`	2	--	ut3¹ ese³		12	EU EA WA	1258
	rs2076324^1,2	A,C,F,H	13977726(-)	`TCATCA/TTCTTC`	3	D/E	mis¹		4	EA WA	460
	rs2697963^1,2	A,C,F,H	14023327(-)	`AACAGA/CGCCCA`	2	--	ut3¹ ese³		4	EU EA WA	412

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HapMap Linkage Disequilibrium images for PRDM2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601196

10/23 Novoseek disease relationships for PRDM2 gene (see all 23 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	70.11	41	7538672 (2), 11135439 (2), 12002276 (2), 12472571 (2) (see all 18)
microsatellite instability	62.88	9	10987271 (4), 15309726 (2), 11135439 (1), 14760116 (1) (see all 5)
wilms tumor	59.77	8	7700638 (1), 9242555 (1), 9484784 (1), 1323141 (1) (see all 8)
tumors	38.71	88	14668725 (5), 17103461 (5), 18712668 (4), 11544182 (4) (see all 33)
allelic loss	34.32	3	14668725 (3)
cancer	30.20	32	10369808 (3), 11135439 (3), 11719434 (3), 17052263 (2) (see all 15)
oligodendroglioma	29.34	1	15711769 (1)
lymphoblastic leukemia acute childhood	27.22	1	15201966 (1)
hepatocellular carcinoma	25.88	9	18712668 (2), 11259086 (2), 17963297 (1), 19173828 (1) (see all 5)
gastric cancer	23.14	10	15309726 (4), 14534544 (3), 11259086 (2), 9144414 (1)

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1 PharmGKB disease relationship for PRDM2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Human Gene Mutation Database: PRDM2
Human Genome Epidemiology Navigator: PRDM2 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/160 PubMed articles for PRDM2 gene (see all 160 ):

The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. (PubMed id 7538672)^{1, 2, 3, 4} Buyse I.M.... Huang S. (1995)
cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme- oxygenase-1 gene. (PubMed id 8654390)^{1, 3, 4} Muraosa Y.... Shibahara S. (1996)
Inactivation of a histone methyltransferase by mutations in human cancers. (PubMed id 14633678)^{1, 3, 4} Kim K.C....Huang S. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter. (PubMed id 9006946)^{3, 4} Liu L.... Huang S. (1997)
Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3. (PubMed id 7590293)^{3, 4} Shapiro V.S.... Winoto A. (1995)
Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia. (PubMed id 12472571)^{1, 3} Sasaki O....Sasaki T. (2002)
RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. (PubMed id 9766644)^{1, 3} He L....Huang S. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7799	HGNC: 9347	AceView: PRDM2	Ensembl:ENSG00000116731	euGenes: HUgn7799
ECgene: PRDM2	H-InvDB: PRDM2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for PRDM2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for PRDM2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PRDM2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PRDM2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PRDM2		Antibodies for PRDM2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PRDM2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PRDM2)
	Antibodies (PRDM2)
	Chimera RNAi (PRDM2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (KMT8/Riz1/Riz2, RIZ1)
	Antibodies (KMT8/Riz1/Riz2, RIZ1)

Search OriGene for PRDM2

Search Tocris compounds for PRDM2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PRDM2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PRDM2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PRDM2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for PRDM2

Summaries
for PRDM2

Genomic Location
for PRDM2

Proteins
for PRDM2

Protein Domains/
Families
for PRDM2

Gene Function
for PRDM2

Pathways & Interactions
for PRDM2

Drugs & Compounds
for PRDM2

Transcripts
for PRDM2

Expression
for PRDM2

Orthologs
for PRDM2

Paralogs
for PRDM2

SNPs/Variants
for PRDM2

Disorders & Mutations
for PRDM2

Medical News
for PRDM2

Publications
for PRDM2

Search for PRDM2

Genome Databases showing PRDM2

Other Databases showing PRDM2

Specialized Databases showing PRDM2

Licensable Technologies
for PRDM2

Services
for PRDM2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PRDM2 (Gene Symbol)
EC 2.1.1.43
HUMHOXY1
KMT8
MTB-ZF
OTTHUMP00000009642
OTTHUMP00000009687
RIZ
RIZ1
RIZ2
GATA-3 binding protein G3B
GATA-3-binding protein G3B
Lysine N-methyltransferase 8
MTE-binding protein
PR domain containing 2, with ZNF domain
PR domain-containing protein 2
Retinoblastoma protein-interacting zinc finger protein
Zinc finger protein RIZ
retinoblastoma protein-binding zinc finger protein
zinc-finger DNA-binding protein

PRDM2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor PRDM2

Summariesfor PRDM2

Genomic Locationfor PRDM2

Proteinsfor PRDM2

Protein Domains/Familiesfor PRDM2

Gene Functionfor PRDM2

Pathways & Interactionsfor PRDM2

Drugs & Compoundsfor PRDM2

Transcriptsfor PRDM2

Expression for PRDM2

Orthologsfor PRDM2

Paralogsfor PRDM2

SNPs/Variantsfor PRDM2

Disorders & Mutationsfor PRDM2

Medical Newsfor PRDM2

Publicationsfor PRDM2

Search for PRDM2

Genome Databases showing PRDM2

Other Databases showing PRDM2

Specialized Databases showing PRDM2

Licensable Technologiesfor PRDM2

Servicesfor PRDM2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PRDM2

Summaries
for PRDM2

Genomic Location
for PRDM2

Proteins
for PRDM2

Protein Domains/
Families
for PRDM2

Gene Function
for PRDM2

Pathways & Interactions
for PRDM2

Drugs & Compounds
for PRDM2

Transcripts
for PRDM2

Expression
for PRDM2

Orthologs
for PRDM2

Paralogs
for PRDM2

SNPs/Variants
for PRDM2

Disorders & Mutations
for PRDM2

Medical News
for PRDM2

Publications
for PRDM2

Licensable Technologies
for PRDM2

Services
for PRDM2