Aliases for PRDM14 Gene
Aliases for PRDM14 Gene
External Ids for PRDM14 Gene
- HGNC: 14001
- Entrez Gene: 63978
- Ensembl: ENSG00000147596
- OMIM: 611781
- UniProtKB: Q9GZV8
Previous GeneCards Identifiers for PRDM14 Gene
- GC08M070904
- GC08M070687
- GC08M071013
- GC08M071127
- GC08M070963
- GC08M066457
Summaries for PRDM14 Gene
-
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
GeneCards Summary for PRDM14 Gene
PRDM14 (PR Domain 14) is a Protein Coding gene. Diseases associated with PRDM14 include Breast Cancer. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Developmental Biology. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM6.
UniProtKB/Swiss-Prot for PRDM14 Gene
-
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM14 Gene
Genomics for PRDM14 Gene
Regulatory Elements for PRDM14 Gene
Enhancers for PRDM14 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around PRDM14 on UCSC Golden Path with GeneCards custom track
Promoters for PRDM14 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around PRDM14 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PRDM14 gene promoter:
Regulatory Element Products
Genomic Location for PRDM14 Gene
- Chromosome:
- 8
- Start:
- 70,051,126 bp from pter
- End:
- 70,071,693 bp from pter
- Size:
- 20,568 bases
- Orientation:
- Minus strand
Genomic View for PRDM14 Gene
Genes around PRDM14 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q13.3 by Ensembl
- 8q13.3 by Entrez Gene
- 8q13.3 by HGNC
PRDM14 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDM14 Gene
Proteins for PRDM14 Gene
-
Protein details for PRDM14 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZV8-PRD14_HUMAN
- Recommended name:
- PR domain zinc finger protein 14
- Protein Accession:
- Q9GZV8
- Q86UX9
Protein attributes for PRDM14 Gene
- Size:
- 571 amino acids
- Molecular mass:
- 64062 Da
- Quaternary structure:
- No Data Available
Protein Expression for PRDM14 Gene
Post-translational modifications for PRDM14 Gene
Other Protein References for PRDM14 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PRDM14
- R&D Systems Antibodies for PRDM14 (PRDM14)
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-
Cloud-Clone Corp. Antibodies for PRDM14
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- antibodies-online Antibodies for PRDM14: See all 68
- GeneTex PRDM14 antibody for PRDM14
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDM14
Protein Products
-
OriGene Purified Proteins for PRDM14
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-
Cloud-Clone Corp. Proteins for PRDM14
- antibodies-online Proteins for PRDM14: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PRDM14
Assay Products
No data available for DME Specific Peptides for PRDM14 Gene
Domains & Families for PRDM14 Gene
Gene Families for PRDM14 Gene
Protein Domains for PRDM14 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDM14 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9GZV8UniProtKB/Swiss-Prot:
PRD14_HUMAN :- The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity.
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Contains 6 C2H2-type zinc fingers.
- Domain:
-
- The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity.
- Contains 1 SET domain.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Similarity:
-
- Contains 6 C2H2-type zinc fingers.
Function for PRDM14 Gene
Molecular function for PRDM14 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.
Enzyme Numbers (IUBMB) for PRDM14 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008168 | methyltransferase activity | IEA | -- |
| GO:0031490 | chromatin DNA binding | IEA | -- |
Phenotypes for PRDM14 Gene
- MGI mutant phenotypes for PRDM14:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PRDM14:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM14 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for PRDM14
-
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Targeted motifs for PRDM14 Gene
HOMER Transcription Factor Regulatory Elements motif PRDM14
- Consensus sequence: AGGTCTCTAACC Submotif: canonical Cell Type: H1 GEO ID: GSE22767
miRNA Products
- Search ViGene Biosciences for PRDM14
Inhibitory RNA Products
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-
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for PRDM14 gene
-
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Flow Cytometry Products
No data available for Human Phenotype Ontology , miRNA and Transcription Factor Targets for PRDM14 Gene
Localization for PRDM14 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDM14 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Gene Ontology (GO) - Cellular Components for PRDM14 Gene
Pathways & Interactions for PRDM14 Gene
More details on SuperPathways for PRDM14| Superpath | Contained pathways | |
|---|---|---|
| 1 | Developmental Biology | |
| 2 | Transcriptional regulation of pluripotent stem cells |
Pathways by source for PRDM14 Gene
2 Reactome pathways for PRDM14 Gene
Interacting Proteins for PRDM14 Gene
Selected Interacting proteins:
Q9GZV8-PRD14_HUMAN
ENSP00000276594
for PRDM14 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001708 | cell fate specification | IEA | -- |
| GO:0001827 | inner cell mass cell fate commitment | IEA | -- |
| GO:0007281 | germ cell development | IEA | -- |
No data available for SIGNOR curated interactions for PRDM14 Gene
Transcripts for PRDM14 Gene
mRNA/cDNA for PRDM14 Gene
- (2) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRDM14 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRDM14
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM14
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miRNA Products
- Search ViGene Biosciences for PRDM14
Inhibitory RNA Products
- Origene RNAi, shRNA, mouse_rna, and siRNA products in human, mouse, rat for PRDM14
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-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM14 gene
Clone Products
- OriGene clones in human for PRDM14
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Flow Cytometry Products
Expression for PRDM14 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Primordial Germ Cell Precursors Epiblast
- Primordial Germ Cells Primitive Gonad
- Primordial Germ Cells Allantois
- Primordial germ cell-like cells(Hayashi K et. al. 2011)
- Inner Cell Mass (Early Embryonic Tissues)
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Germ Cells (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for PRDM14 Gene
This gene is overexpressed in Testis (x44.4) and Kidney - Cortex (x4.6).
This gene is overexpressed in Cerebrospinal fluid (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRDM14 Gene
SOURCE GeneReport for Unigene cluster for PRDM14 Gene Hs.736037
mRNA Expression by UniProt/SwissProt for PRDM14 Gene
Q9GZV8-PRD14_HUMAN
Tissue specificity:
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
Primer Products
-
OriGene qPCR primer pairs for PRDM14
-
OriGene qPCR primer pairs and template standards for PRDM14
Orthologs for PRDM14 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | PRDM14 35 |
|
||
| PRDM14 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | PRDM14 35 |
|
||
| PRDM14 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Prdm14 35 |
|
||
| Prdm14 16 |
|
||||
| Prdm14 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | PRDM14 35 |
|
||
| PRDM14 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | LOC100365184 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRDM14 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM14 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100858709 35 |
|
||
| PRDM14 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PRDM14 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdm14 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prdm14 35 |
|
||
| prdm14 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | F47E1.3 37 |
|
|
|
| F47E1.3 36 |
|
OneToOne |
- Species with no ortholog for PRDM14:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRDM14 Gene
(3) SIMAP similar genes for PRDM14 Gene using alignment to 2 proteins:
Variants for PRDM14 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs3750228 | - | 70,068,503(+) | GTCTT(C/T)ATCCA | reference, missense, utr-variant-5-prime | |
| rs7833552 | -- | 70,059,507(+) | tcttg(A/T)gatcc | intron-variant | |
| rs7834989 | -- | 70,063,587(+) | ggcgc(C/G)atctc | intron-variant | |
| rs7835836 | -- | 70,063,944(+) | TTTTT(C/G)CCTCC | intron-variant | |
| rs7841485 | -- | 70,066,224(+) | GAGGG(C/T)GTGCA | intron-variant |
Residual Variation Intolerance Score:
31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.80;
83.39% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRDM14 Gene
Disorders for PRDM14 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
Search PRDM14 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PRDM14
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDM14 Gene
Publications for PRDM14 Gene
- A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. (PMID: 20953172) Chia N.Y. … Ng H.H. (Nature 2010) 3 4 67
- Systematic identification of molecular links between core and candidate genes in breast cancer. (PMID: 25640309) Arroyo R. … Aloy P. (J. Mol. Biol. 2015) 3
- Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. (PMID: 25750208) Sugawa F. … SchAPler H.R. (EMBO J. 2015) 3
- Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
- Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers. (PMID: 25233927) Snellenberg S. … Steenbergen R.D. (Carcinogenesis 2014) 3
Products for PRDM14 Gene
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- OriGene qPCR primer pairs for PRDM14
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- Cloud-Clone Corp. Antibodies for PRDM14
- Cloud-Clone Corp. Proteins for PRDM14
- Browse Assay Kits at Cloud-Clone Corp.
- antibodies-online Antibodies for PRDM14: See all 68
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- antibodies-online Proteins for PRDM14: See all 5
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- GeneTex PRDM14 antibody for PRDM14
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- ViGene Biosciences adenoviral particle packaged cDNA for PRDM14 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for PRDM14
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- Santa Cruz Biotechnology (SCBT) CRISPR for PRDM14
Sources for PRDM14 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (128) RVIS
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- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon