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PRDM14 Gene(Protein Coding)

PR/SET Domain 14

GCID:
GC08M070063
GIFtS:
55
Genes Participants
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Aliases for PRDM14 Gene

Aliases for PRDM14 Gene

  • PR/SET Domain 14 2 3 5
  • PR Domain-Containing Protein 14 3 4
  • PR Domain 14 2 3
  • PR Domain Zinc Finger Protein 14 3
  • PR Domain Containing 14 2
  • PR Domain-Containing 14 3
  • EC 2.1.1.- 4
  • PFM11 3

External Ids for PRDM14 Gene

Previous GeneCards Identifiers for PRDM14 Gene

  • GC08M070904
  • GC08M070687
  • GC08M071013
  • GC08M071127
  • GC08M070963
  • GC08M066457

Summaries for PRDM14 Gene

Entrez Gene Summary for PRDM14 Gene

  • This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRDM14 Gene

PRDM14 (PR/SET Domain 14) is a Protein Coding gene. Diseases associated with PRDM14 include Breast Cancer. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Developmental Biology. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM6.

UniProtKB/Swiss-Prot for PRDM14 Gene

  • Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM14 Gene

Genomics for PRDM14 Gene

Products:

  1. Regulatory Element

Regulatory Elements for PRDM14 Gene

Enhancers for PRDM14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F070441 1.2 Ensembl ENCODE 16.2 -370.7 -370722 1.5 PKNOX1 KLF17 FEZF1 ZNF2 ZBTB40 ZNF121 ZNF366 SCRT2 KLF7 ZNF391 RPL13P11 H2AFZP2 PRDM14 LOC105375889 XKR9 RPS18P11 LOC101926892
GH08F070072 0.4 FANTOM5 9.8 +1.1 1126 0.1 EZH2 PRDM14 SUMO2P20
GH08F070069 0.6 ENCODE 0.8 +1.6 1633 0.2 SMARCA4 RNF2 CBX2 BMI1 EZH2 PRDM14 SUMO2P20
GH08F070070 0.5 ENCODE 0.8 -0.1 -136 2.2 POLR2A CBX2 CTBP2 EZH2 LOC101929759 SLCO5A1 PRDM14 RNU1-101P
GH08F070073 0.5 ENCODE 0.8 +2.1 2073 0.2 POLR2A CBX2 EZH2 PRDM14 SUMO2P20
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRDM14 on UCSC Golden Path with GeneCards custom track

Promoters for PRDM14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001393963 -407 601 SMARCA4 POLR2A CBX2 EZH2

Transcription factor binding sites by QIAGEN in the PRDM14 gene promoter:

Genomic Location for PRDM14 Gene

Chromosome:
8
Start:
70,051,126 bp from pter
End:
70,071,693 bp from pter
Size:
20,568 bases
Orientation:
Minus strand

Genomic View for PRDM14 Gene

Genes around PRDM14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDM14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDM14 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PRDM14 Gene

Proteins for PRDM14 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PRDM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV8-PRD14_HUMAN
    Recommended name:
    PR domain zinc finger protein 14
    Protein Accession:
    Q9GZV8
    Secondary Accessions:
    • Q86UX9

    Protein attributes for PRDM14 Gene

    Size:
    571 amino acids
    Molecular mass:
    64062 Da
    Quaternary structure:
    • Interacts with CBFA2T2.

neXtProt entry for PRDM14 Gene

Protein Expression for PRDM14 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PRDM14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDM14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRDM14 Gene

Domains & Families for PRDM14 Gene

Gene Families for PRDM14 Gene

HGNC:

Protein Domains for PRDM14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRDM14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZV8

UniProtKB/Swiss-Prot:

PRD14_HUMAN :
  • The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 6 C2H2-type zinc fingers.
Domain:
  • The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity.
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PRDM14: view

Function for PRDM14 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for PRDM14 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.

Enzyme Numbers (IUBMB) for PRDM14 Gene

Gene Ontology (GO) - Molecular Function for PRDM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PRDM14: view
genes like me logo Genes that share phenotypes with PRDM14: view

Animal Models for PRDM14 Gene

MGI Knock Outs for PRDM14:

Animal Model Products

Targeted motifs for PRDM14 Gene
HOMER Transcription Factor Regulatory Elements motif PRDM14
  • Consensus sequence: AGGTCTCTAACC Submotif: canonical Cell Type: H1 GEO ID: GSE22767

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA and Transcription Factor Targets for PRDM14 Gene

Localization for PRDM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM14 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRDM14 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for PRDM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PRDM14: view

Pathways & Interactions for PRDM14 Gene

genes like me logo Genes that share pathways with PRDM14: view

Pathways by source for PRDM14 Gene

Gene Ontology (GO) - Biological Process for PRDM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000902 cell morphogenesis IEA --
GO:0001708 cell fate specification IEA --
GO:0001827 inner cell mass cell fate commitment IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRDM14: view

No data available for SIGNOR curated interactions for PRDM14 Gene

Drugs & Compounds for PRDM14 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for PRDM14 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for PRDM14 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRDM14 Gene

PR domain containing 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM14 Gene

No ASD Table

Relevant External Links for PRDM14 Gene

GeneLoc Exon Structure for
PRDM14
ECgene alternative splicing isoforms for
PRDM14

Expression for PRDM14 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRDM14 Gene

mRNA expression in normal human tissues for PRDM14 Gene
mRNA expression by BioGPS for PRDM14 GenemRNA expression by GTEx for PRDM14 Gene

mRNA differential expression in normal tissues according to GTEx for PRDM14 Gene

This gene is overexpressed in Testis (x44.4) and Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for PRDM14 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRDM14 Gene



Protein tissue co-expression partners for PRDM14 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRDM14 Gene:

PRDM14

SOURCE GeneReport for Unigene cluster for PRDM14 Gene:

Hs.736037

mRNA Expression by UniProt/SwissProt for PRDM14 Gene:

Q9GZV8-PRD14_HUMAN
Tissue specificity: Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
genes like me logo Genes that share expression patterns with PRDM14: view

Primer Products

Orthologs for PRDM14 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PRDM14 34 35
  • 99.53 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia PRDM14 35
  • 89 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia PRDM14 34 35
  • 85.68 (n)
cow
(Bos Taurus)
 Mammalia PRDM14 34 35
  • 83.77 (n)
oppossum
(Monodelphis domestica)
 Mammalia PRDM14 35
  • 78 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia LOC100365184 34
  • 77.02 (n)
mouse
(Mus musculus)
 Mammalia Prdm14 34 16 35
  • 76.11 (n)
chicken
(Gallus gallus)
 Aves PRDM14 35
  • 72 (a)
 OneToOne
LOC100858709 34
  • 66.1 (n)
lizard
(Anolis carolinensis)
 Reptilia PRDM14 35
  • 63 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia prdm14 34
  • 62.24 (n)
zebrafish
(Danio rerio)
 Actinopterygii prdm14 34 35
  • 65.44 (n)
worm
(Caenorhabditis elegans)
 Secernentea F47E1.3 36 35
  • 76 (a)
Species where no ortholog for PRDM14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDM14 Gene

ENSEMBL:
Gene Tree for PRDM14 (if available)
TreeFam:
Gene Tree for PRDM14 (if available)

Paralogs for PRDM14 Gene

Paralogs for PRDM14 Gene

(3) SIMAP similar genes for PRDM14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRDM14: view

Variants for PRDM14 Gene

Sequence variations from dbSNP and Humsavar for PRDM14 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10089937 -- 70,052,164(+) CCATC(A/G)TCCTC reference, synonymous-codon
rs10100262 -- 70,059,813(+) TTGTg(A/C)ccagg intron-variant
rs10111497 -- 70,059,106(+) CCCAC(G/T)ACCAC intron-variant
rs10112742 -- 70,056,118(+) CATGT(A/G)AGCCA intron-variant
rs10112802 -- 70,055,944(+) TTCCC(A/G)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM14 Gene

Variant ID Type Subtype PubMed ID
nsv1023889 CNV gain+loss 25217958
nsv1034456 CNV gain 25217958
nsv1068714 OTHER inversion 25765185
nsv508513 CNV deletion 20534489
nsv527289 CNV gain 19592680
nsv611487 CNV loss 21841781
nsv831352 CNV gain 17160897

Variation tolerance for PRDM14 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.80; 83.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDM14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRDM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM14 Gene

Disorders for PRDM14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRDM14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRDM14

Genetic Association Database (GAD)
PRDM14
Human Genome Epidemiology (HuGE) Navigator
PRDM14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDM14
genes like me logo Genes that share disorders with PRDM14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDM14 Gene

Publications for PRDM14 Gene

  1. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. (PMID: 20953172) Chia N.Y. … Ng H.H. (Nature 2010) 3 4 64
  2. Gene amplification and overexpression of PRDM14 in breast cancers. (PMID: 17942894) Nishikawa N. … Tokino T. (Cancer Res. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. [Research Progress of PR Domain Zinc Finger Protein 14]. (PMID: 26903163) Han Y. … Lin Q. (Zhongguo Fei Ai Za Zhi 2016) 3 64

Products for PRDM14 Gene

Sources for PRDM14 Gene

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