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Aliases for PRDM14 Gene

Aliases for PRDM14 Gene

  • PR Domain Containing 14 2 3
  • PR Domain-Containing Protein 14 3 4
  • PR Domain-Containing 14 3
  • EC 2.1.1.- 4
  • PFM11 3

External Ids for PRDM14 Gene

Previous GeneCards Identifiers for PRDM14 Gene

  • GC08M070904
  • GC08M070687
  • GC08M071013
  • GC08M071127
  • GC08M070963
  • GC08M066457

Summaries for PRDM14 Gene

Entrez Gene Summary for PRDM14 Gene

  • This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

GeneCards Summary for PRDM14 Gene

PRDM14 (PR Domain Containing 14) is a Protein Coding gene. Among its related pathways are Developmental Biology and POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM11.

UniProtKB/Swiss-Prot for PRDM14 Gene

  • Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM14 Gene

Genomics for PRDM14 Gene

Regulatory Elements for PRDM14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRDM14 Gene

Chromosome:
8
Start:
70,051,126 bp from pter
End:
70,071,693 bp from pter
Size:
20,568 bases
Orientation:
Minus strand

Genomic View for PRDM14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDM14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM14 Gene

Proteins for PRDM14 Gene

  • Protein details for PRDM14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZV8-PRD14_HUMAN
    Recommended name:
    PR domain zinc finger protein 14
    Protein Accession:
    Q9GZV8
    Secondary Accessions:
    • Q86UX9

    Protein attributes for PRDM14 Gene

    Size:
    571 amino acids
    Molecular mass:
    64062 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRDM14 Gene

Proteomics data for PRDM14 Gene at MOPED

Post-translational modifications for PRDM14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDM14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for PRDM14

No data available for DME Specific Peptides for PRDM14 Gene

Domains & Families for PRDM14 Gene

Gene Families for PRDM14 Gene

Protein Domains for PRDM14 Gene

Suggested Antigen Peptide Sequences for PRDM14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZV8

UniProtKB/Swiss-Prot:

PRD14_HUMAN :
  • The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 6 C2H2-type zinc fingers.
Domain:
  • The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PRDM14: view

Function for PRDM14 Gene

Molecular function for PRDM14 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5-GGTC[TC]CTAA-3.

Enzyme Numbers (IUBMB) for PRDM14 Gene

Gene Ontology (GO) - Molecular Function for PRDM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0008168 methyltransferase activity IEA --
GO:0031490 chromatin DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRDM14: view
genes like me logo Genes that share phenotypes with PRDM14: view

Animal Models for PRDM14 Gene

MGI Knock Outs for PRDM14:

Animal Model Products

Targeted motifs for PRDM14 Gene
HOMER Transcription Factor Regulatory Elements motif PRDM14
  • Consensus sequence: AGGTCTCTAACC Submotif: canonical Cell Type: H1 GEO ID: GSE22767

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM14

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA and Transcription Factor Targets for PRDM14 Gene

Localization for PRDM14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDM14 Gene COMPARTMENTS Subcellular localization image for PRDM14 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for PRDM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PRDM14: view

Pathways & Interactions for PRDM14 Gene

genes like me logo Genes that share pathways with PRDM14: view

Pathways by source for PRDM14 Gene

Gene Ontology (GO) - Biological Process for PRDM14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000902 cell morphogenesis IEA --
GO:0001708 cell fate specification IEA --
GO:0001827 inner cell mass cell fate commitment IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRDM14: view

No data available for SIGNOR curated interactions for PRDM14 Gene

Drugs & Compounds for PRDM14 Gene

No Compound Related Data Available

Transcripts for PRDM14 Gene

mRNA/cDNA for PRDM14 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRDM14 Gene

PR domain containing 14:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM14 Gene

No ASD Table

Relevant External Links for PRDM14 Gene

GeneLoc Exon Structure for
PRDM14
ECgene alternative splicing isoforms for
PRDM14

Expression for PRDM14 Gene

mRNA expression in normal human tissues for PRDM14 Gene

mRNA differential expression in normal tissues according to GTEx for PRDM14 Gene

This gene is overexpressed in Testis (x44.4) and Kidney - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for PRDM14 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRDM14 Gene



SOURCE GeneReport for Unigene cluster for PRDM14 Gene Hs.736037

mRNA Expression by UniProt/SwissProt for PRDM14 Gene

Q9GZV8-PRD14_HUMAN
Tissue specificity: Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
genes like me logo Genes that share expression patterns with PRDM14: view

Protein tissue co-expression partners for PRDM14 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for PRDM14 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDM14 35
  • 83.77 (n)
  • 80.95 (a)
PRDM14 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDM14 35
  • 85.68 (n)
  • 80.63 (a)
PRDM14 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdm14 35
  • 76.11 (n)
  • 70.94 (a)
Prdm14 16
Prdm14 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRDM14 35
  • 99.53 (n)
  • 100 (a)
PRDM14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100365184 35
  • 77.02 (n)
  • 73.1 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDM14 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM14 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858709 35
  • 66.1 (n)
  • 66.02 (a)
PRDM14 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDM14 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm14 35
  • 62.24 (n)
  • 60.31 (a)
zebrafish
(Danio rerio)
Actinopterygii prdm14 35
  • 65.44 (n)
  • 65.72 (a)
prdm14 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F47E1.3 37
  • 76 (a)
F47E1.3 36
  • 31 (a)
OneToOne
Species with no ortholog for PRDM14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDM14 Gene

ENSEMBL:
Gene Tree for PRDM14 (if available)
TreeFam:
Gene Tree for PRDM14 (if available)

Paralogs for PRDM14 Gene

Paralogs for PRDM14 Gene

(3) SIMAP similar genes for PRDM14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRDM14: view

Variants for PRDM14 Gene

Sequence variations from dbSNP and Humsavar for PRDM14 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1982413 -- 70,051,093(+) tgcct(C/T)ggcct downstream-variant-500B
rs3750225 -- 70,055,372(+) GAAGA(C/T)TGAGA reference, synonymous-codon
rs3750226 -- 70,055,492(+) AGAAC(C/T)CTTTT intron-variant
rs3750227 -- 70,066,455(+) TTCCC(C/T)GTACC synonymous-codon, reference
rs3750228 - 70,068,503(+) GTCTT(C/T)ATCCA reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PRDM14 Gene

Variant ID Type Subtype PubMed ID
nsv527289 CNV Gain 19592680
nsv508513 CNV Loss 20534489
nsv831352 CNV Gain 17160897

Variation tolerance for PRDM14 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.80; 83.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRDM14 Gene

HapMap Linkage Disequilibrium report
PRDM14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM14 Gene

Disorders for PRDM14 Gene

Relevant External Links for PRDM14

Genetic Association Database (GAD)
PRDM14
Human Genome Epidemiology (HuGE) Navigator
PRDM14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDM14
genes like me logo Genes that share disorders with PRDM14: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRDM14 Gene

Publications for PRDM14 Gene

  1. Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile. (PMID: 25750208) Sugawa F. … SchAPler H.R. (EMBO J. 2015) 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Methylation-mediated repression of PRDM14 contributes to apoptosis evasion in HPV-positive cancers. (PMID: 25233927) Snellenberg S. … Steenbergen R.D. (Carcinogenesis 2014) 67
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 67
  5. A PRC2-dependent repressive role of PRDM14 in human embryonic stem cells and induced pluripotent stem cell reprogramming. (PMID: 23280602) Chan Y.S. … Ng H.H. (Stem Cells 2013) 67

Products for PRDM14 Gene

Sources for PRDM14 Gene

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