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Aliases for PRDM12 Gene

Aliases for PRDM12 Gene

  • PR Domain Containing 12 2 3
  • PR-Domain Zinc Finger Protein 12 2 3
  • PR-Domain Containing Protein 12 2 3
  • PR Domain-Containing Protein 12 3 4
  • PFM9 3 4
  • PR Domain Zinc Finger Protein 12 3
  • EC 2.1.1.- 4

External Ids for PRDM12 Gene

Previous GeneCards Identifiers for PRDM12 Gene

  • GC09P124554
  • GC09P125086
  • GC09P126893
  • GC09P128816
  • GC09P130569
  • GC09P132529
  • GC09P133539
  • GC09P103027

Summaries for PRDM12 Gene

GeneCards Summary for PRDM12 Gene

PRDM12 (PR Domain Containing 12) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity. An important paralog of this gene is PRDM11.

UniProtKB/Swiss-Prot for PRDM12 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM12 Gene

Genomics for PRDM12 Gene

Regulatory Elements for PRDM12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRDM12 Gene

Start:
130,664,594 bp from pter
End:
130,682,997 bp from pter
Size:
18,404 bases
Orientation:
Plus strand

Genomic View for PRDM12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRDM12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM12 Gene

Proteins for PRDM12 Gene

  • Protein details for PRDM12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4Q4-PRD12_HUMAN
    Recommended name:
    PR domain zinc finger protein 12
    Protein Accession:
    Q9H4Q4
    Secondary Accessions:
    • A3KFK9

    Protein attributes for PRDM12 Gene

    Size:
    367 amino acids
    Molecular mass:
    40403 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PRDM12 Gene

neXtProt entry for PRDM12 Gene

Proteomics data for PRDM12 Gene at MOPED

Post-translational modifications for PRDM12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRDM12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRDM12 Gene

Domains for PRDM12 Gene

Gene Families for PRDM12 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for PRDM12 Gene

Suggested Antigen Peptide Sequences for PRDM12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4Q4

UniProtKB/Swiss-Prot:

PRD12_HUMAN :
  • Q9H4Q4
Domain:
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PRDM12: view

Function for PRDM12 Gene

Molecular function for PRDM12 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Enzyme Numbers (IUBMB) for PRDM12 Gene

Gene Ontology (GO) - Molecular Function for PRDM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding --
GO:0008168 methyltransferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRDM12: view

Phenotypes for PRDM12 Gene

GenomeRNAi human phenotypes for PRDM12:
genes like me logo Genes that share phenotypes with PRDM12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM12

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRDM12 Gene

Localization for PRDM12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDM12 Gene COMPARTMENTS Subcellular localization image for PRDM12 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PRDM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PRDM12: view

Pathways for PRDM12 Gene

SuperPathways for PRDM12 Gene

No Data Available

Interacting Proteins for PRDM12 Gene

Gene Ontology (GO) - Biological Process for PRDM12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0022008 neurogenesis IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with PRDM12: view

No data available for Pathways by source for PRDM12 Gene

Transcripts for PRDM12 Gene

mRNA/cDNA for PRDM12 Gene

(7) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRDM12 Gene

PR domain containing 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRDM12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRDM12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM12 Gene

No ASD Table

Relevant External Links for PRDM12 Gene

GeneLoc Exon Structure for
PRDM12
ECgene alternative splicing isoforms for
PRDM12

Expression for PRDM12 Gene

mRNA expression in normal human tissues for PRDM12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRDM12 Gene

This gene is overexpressed in Brain - Hypothalamus (7.1), Brain - Cortex (4.6), Brain - Anterior cingulate cortex (BA24) (4.4), and Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PRDM12 Gene

SOURCE GeneReport for Unigene cluster for PRDM12 Gene Hs.495311

genes like me logo Genes that share expressions with PRDM12: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRDM12 Gene

Orthologs for PRDM12 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRDM12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRDM12 35
  • 99.8 (n)
  • 100 (a)
PRDM12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRDM12 35
  • 94.01 (n)
  • 98.8 (a)
PRDM12 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608616 35
  • 94.39 (n)
  • 97.94 (a)
PRDM12 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdm12 35
  • 91.42 (n)
  • 98.5 (a)
Prdm12 16
Prdm12 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRDM12 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM12 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdm12 35
  • 90.62 (n)
  • 98.5 (a)
chicken
(Gallus gallus)
Aves PRDM12 35
  • 88.32 (n)
  • 93.66 (a)
PRDM12 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68944 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm12 35
  • 80.64 (n)
  • 90.12 (a)
zebrafish
(Danio rerio)
Actinopterygii prdm12b 35
  • 79.38 (n)
  • 88.29 (a)
prdm12b 36
  • 83 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea set-17 36
  • 14 (a)
OneToMany
Species with no ortholog for PRDM12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRDM12 Gene

ENSEMBL:
Gene Tree for PRDM12 (if available)
TreeFam:
Gene Tree for PRDM12 (if available)

Paralogs for PRDM12 Gene

Paralogs for PRDM12 Gene

genes like me logo Genes that share paralogs with PRDM12: view

Variants for PRDM12 Gene

Sequence variations from dbSNP and Humsavar for PRDM12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs894241 -- 130,678,075(-) TGTTC(C/T)GGAAA intron-variant
rs894242 -- 130,677,900(-) GAGTC(C/T)AGTTC intron-variant
rs894243 -- 130,677,800(-) AGGAT(A/G)TTGGT intron-variant
rs1545229 -- 130,674,746(-) ATTGT(A/G)TAAAC intron-variant
rs1866974 -- 130,665,769(-) AAAGG(G/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM12 Gene

Variant ID Type Subtype PubMed ID
nsv831735 CNV Loss 17160897
nsv825122 CNV Gain 20364138
nsv825123 CNV Gain 20364138
nsv825124 CNV Gain 20364138

Relevant External Links for PRDM12 Gene

HapMap Linkage Disequilibrium report
PRDM12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM12 Gene

Disorders for PRDM12 Gene

No disorders were found for PRDM12 Gene.

No data available for UniProtKB/Swiss-Prot for PRDM12 Gene

Publications for PRDM12 Gene

  1. A potential role for PRDM12 in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion. (PMID: 14523459) Reid A.G. … Nacheva E.P. (Leukemia 2004) 2 3
  2. SET domains and histone methylation. (PMID: 14675547) Xiao B. … Gamblin S.J. (Curr. Opin. Struct. Biol. 2003) 3
  3. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. (PMID: 24315451) van der Valk R.J. … de Jongste J.C. (J. Allergy Clin. Immunol. 2014) 3
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  5. The yin-yang of PR-domain family genes in tumorigenesis. (PMID: 10668202) Jiang G.L. … Huang S. (Histol. Histopathol. 2000) 3

Products for PRDM12 Gene

Sources for PRDM12 Gene

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