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Aliases for PRDM10 Gene

Aliases for PRDM10 Gene

  • PR Domain 10 2 3
  • PR Domain Containing 10 2 3 5
  • Tristanin 2 3 4
  • PRDM Zinc Finger Transcription Factor 2 3
  • PR Domain-Containing Protein 10 3 4
  • PR-Domain Family Member 7 2 3
  • PFM7 3 4
  • EC 2.1.1.- 4
  • KIAA1231 4
  • TRIS 4

External Ids for PRDM10 Gene

Previous GeneCards Identifiers for PRDM10 Gene

  • GC11M131770
  • GC11M131282
  • GC11M129803
  • GC11M129307
  • GC11M129274
  • GC11M125721
  • GC11M129769

Summaries for PRDM10 Gene

Entrez Gene Summary for PRDM10 Gene

  • The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRDM10 Gene

PRDM10 (PR Domain 10) is a Protein Coding gene. Diseases associated with PRDM10 include Undifferentiated Pleomorphic Sarcoma and Intraventricular Meningioma. GO annotations related to this gene include nucleic acid binding and methyltransferase activity. An important paralog of this gene is PRDM4.

UniProtKB/Swiss-Prot for PRDM10 Gene

  • May be involved in transcriptional regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM10 Gene

Genomics for PRDM10 Gene

Regulatory Elements for PRDM10 Gene

Enhancers for PRDM10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRDM10 on UCSC Golden Path with GeneCards custom track

Promoters for PRDM10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRDM10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRDM10 Gene

Chromosome:
11
Start:
129,899,706 bp from pter
End:
130,003,050 bp from pter
Size:
103,345 bases
Orientation:
Minus strand

Genomic View for PRDM10 Gene

Genes around PRDM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRDM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRDM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRDM10 Gene

Proteins for PRDM10 Gene

  • Protein details for PRDM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQV6-PRD10_HUMAN
    Recommended name:
    PR domain zinc finger protein 10
    Protein Accession:
    Q9NQV6
    Secondary Accessions:
    • B7ZL71
    • G3XAE5
    • J3KP23
    • Q17R90
    • Q2KHR4
    • Q863Z2
    • Q9NXI4
    • Q9ULI9

    Protein attributes for PRDM10 Gene

    Size:
    1147 amino acids
    Molecular mass:
    130136 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91026.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRDM10 Gene

    Alternative splice isoforms for PRDM10 Gene

neXtProt entry for PRDM10 Gene

Proteomics data for PRDM10 Gene at MOPED

Post-translational modifications for PRDM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRDM10 Gene

Domains & Families for PRDM10 Gene

Gene Families for PRDM10 Gene

Protein Domains for PRDM10 Gene

Suggested Antigen Peptide Sequences for PRDM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQV6

UniProtKB/Swiss-Prot:

PRD10_HUMAN :
  • The SET domain is degenerated, suggesting that it has lost methyltransferase activity.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
  • Contains 10 C2H2-type zinc fingers.
Domain:
  • The SET domain is degenerated, suggesting that it has lost methyltransferase activity.
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with PRDM10: view

Function for PRDM10 Gene

Molecular function for PRDM10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Enzyme Numbers (IUBMB) for PRDM10 Gene

Gene Ontology (GO) - Molecular Function for PRDM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with PRDM10: view
genes like me logo Genes that share phenotypes with PRDM10: view

Animal Models for PRDM10 Gene

MGI Knock Outs for PRDM10:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRDM10 Gene

Localization for PRDM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRDM10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRDM10 Gene COMPARTMENTS Subcellular localization image for PRDM10 gene
Compartment Confidence
nucleus 5
chloroplast 2
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
plasma membrane 2
vacuole 2
golgi apparatus 1
lysosome 1

No data available for Gene Ontology (GO) - Cellular Components for PRDM10 Gene

Pathways & Interactions for PRDM10 Gene

SuperPathways for PRDM10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRDM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with PRDM10: view

No data available for Pathways by source and SIGNOR curated interactions for PRDM10 Gene

Drugs & Compounds for PRDM10 Gene

No Compound Related Data Available

Transcripts for PRDM10 Gene

Unigene Clusters for PRDM10 Gene

PR domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRDM10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for PRDM10 Gene

GeneLoc Exon Structure for
PRDM10
ECgene alternative splicing isoforms for
PRDM10

Expression for PRDM10 Gene

mRNA expression in normal human tissues for PRDM10 Gene

Protein differential expression in normal tissues from HIPED for PRDM10 Gene

This gene is overexpressed in Heart (42.2), Plasma (12.2), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRDM10 Gene



SOURCE GeneReport for Unigene cluster for PRDM10 Gene Hs.275086

genes like me logo Genes that share expression patterns with PRDM10: view

Protein tissue co-expression partners for PRDM10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRDM10 Gene

Orthologs for PRDM10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PRDM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRDM10 35
  • 88.19 (n)
  • 94.02 (a)
PRDM10 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRDM10 35
  • 88.68 (n)
  • 95.1 (a)
PRDM10 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prdm10 35
  • 85.19 (n)
  • 90.29 (a)
Prdm10 16
Prdm10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRDM10 35
  • 97.33 (n)
  • 97 (a)
PRDM10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prdm10 35
  • 87.98 (n)
  • 94.08 (a)
oppossum
(Monodelphis domestica)
Mammalia PRDM10 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRDM10 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRDM10 35
  • 78.35 (n)
  • 86.68 (a)
PRDM10 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRDM10 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prdm10 35
  • 70.42 (n)
  • 76 (a)
zebrafish
(Danio rerio)
Actinopterygii prdm10 35
  • 67.86 (n)
  • 71.35 (a)
prdm10 36
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for PRDM10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRDM10 Gene

ENSEMBL:
Gene Tree for PRDM10 (if available)
TreeFam:
Gene Tree for PRDM10 (if available)

Paralogs for PRDM10 Gene

Paralogs for PRDM10 Gene

genes like me logo Genes that share paralogs with PRDM10: view

Variants for PRDM10 Gene

Sequence variations from dbSNP and Humsavar for PRDM10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2241571 - 129,925,055(-) GCAGC(A/G)CATCC reference, missense
rs11221912 - 129,960,901(+) CTGTG(C/T)GGCAT reference, missense, utr-variant-5-prime
rs999181 -- 129,954,757(-) TGTTC(A/G)AGGCT intron-variant
rs1043654 -- 129,900,031(-) TTATC(A/G)TTGAT utr-variant-3-prime
rs1161662 -- 129,909,792(+) CAGCA(C/T)GAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRDM10 Gene

Variant ID Type Subtype PubMed ID
nsv898454 CNV Gain 21882294
nsv468893 CNV Gain 19166990
nsv39533 CNV Loss 16902084
dgv1322n71 CNV Loss 21882294

Variation tolerance for PRDM10 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRDM10 Gene

Disorders for PRDM10 Gene

MalaCards: The human disease database

(9) MalaCards diseases for PRDM10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
undifferentiated pleomorphic sarcoma
  • malignant fibrous histiocytoma
intraventricular meningioma
tinea unguium
  • cellulitis and abscess
extraosseous osteosarcoma
  • extraskeletal osteogenic sarcoma
pyosalpinx
  • pyosalpingitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PRDM10

Genetic Association Database (GAD)
PRDM10
Human Genome Epidemiology (HuGE) Navigator
PRDM10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRDM10
genes like me logo Genes that share disorders with PRDM10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRDM10 Gene

Publications for PRDM10 Gene

  1. Ectopic dendrite initiation: CNS pathogenesis as a model of CNS development. (PMID: 12175877) Siegel D.A. … Becker S.F. (Int. J. Dev. Neurosci. 2002) 2 3 4 67
  2. Recurrent PRDM10 gene fusions in undifferentiated pleomorphic sarcoma. (PMID: 25516889) Hofvander J. … Mertens F. (Clin. Cancer Res. 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for PRDM10 Gene

Sources for PRDM10 Gene

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