Aliases for PRDM1 Gene
External Ids for PRDM1 Gene
Previous HGNC Symbols for PRDM1 Gene
Previous GeneCards Identifiers for PRDM1 Gene
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDM1 Gene
PRDM1 (PR Domain Containing 1, With ZNF Domain) is a Protein Coding gene. Diseases associated with PRDM1 include plasmacytoma and central nervous system lymphoma. Among its related pathways are Direct p53 effectors and Lymphocyte Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and methyltransferase activity. An important paralog of this gene is ZNF827.
UniProtKB/Swiss-Prot for PRDM1 Gene
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569).