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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PRDM1 Gene

protein-coding GIFtS: 62
GCID: GC06P106579

PR domain containing 1, with ZNF domain

(Previous symbol: BLIMP1)

Explore 26 diseases affiliated with
PRDM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PR Domain Containing 1, With ZNF Domain¹ ²		PR Domain Zinc Finger Protein 1²
BLIMP1¹ ² ³ ⁵		PRDI-Binding Factor-1²
PRDI-BF1¹ ² ³		Beta-Interferon Gene Positive Regulatory Domain I-Binding Factor³
BLIMP-1² ³		Positive Regulatory Domain I-Binding Factor 1³
B-Lymphocyte-Induced Maturation Protein 1²		PR Domain-Containing Protein 1³
Beta-Interferon Gene Positive-Regulatory Domain I Binding Factor²		PRDI-Binding Factor 1³

External Ids:	HGNC: 9346¹	Entrez Gene: 639²	Ensembl: ENSG00000057657⁷	OMIM: 603423⁵	UniProtKB: O75626³

Export aliases for PRDM1 gene to outside databases

Previous GC identifers: GC06P106371 GC06P106557 GC06P106640 GC06P103981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PRDM1:

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically

to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases

upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626

Function: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon

gene. Drives the maturation of B-lymphocytes into Ig secreting cells

Gene Wiki entry for PRDM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PRDM1 gene promoter:
GR p53 STAT3 IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRDM1 promoter sequence

Search SABiosciences Chromatin IP Primers for PRDM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRDM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21

PRDM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRDM1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P106579: view genomic region (about GC identifiers)

Start:	106,534,195 bp from pter	End:	106,557,814 bp from pter
Size:	23,620 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626 (See protein sequence)

Recommended Name: PR domain zinc finger protein 1

Size: 825 amino acids; 91771 Da

Subunit: Interacts with PRMT5 (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm

Sequence caution: Sequence=AAO45623.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for PRDM1:

3DAL (3D)

Secondary accessions: B2REA6 E1P5E0 Q86WM7

Alternative splicing: 3 isoforms: O75626-1 O75626-2 O75626-3

Explore the universe of human proteins at neXtProt for PRDM1: NX_O75626

Post-translational modifications:

Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell

differentiation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75626

PRDM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001189.2 NP_878911.1

ENSEMBL proteins:

ENSP00000358087 ENSP00000358092 ENSP00000395566 ENSP00000399772 ENSP00000358085

Human Recombinant Protein Products:

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	Novus Biologicals PRDM1 Proteins Novus Biologicals PRDM1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PRDM1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--

PRDM1 for ontologies About GeneDecksing

PRDM1 Antibody Products:

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	Uscn ELISAs and CLIAs for PRDM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PRDM1 for domains About GeneDecksing

5 InterPro domains/families:

IPR001214 SET_dom

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

IPR016608 Znf_PRDM1

Graphical View of Domain Structure for InterPro Entry O75626

ProtoNet protein and cluster: O75626

1 Blocks protein family: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626

Similarity: Contains 4 C2H2-type zinc fingers

Similarity: Contains 1 SET domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PRDM1_HUMAN, O75626

Function: Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon

gene. Drives the maturation of B-lymphocytes into Ig secreting cells

Genatlas biochemistry entry for PRDM1:

PR domain containing 1,B-lymphocyte maturation promoting transcription factor,repressing the expression of IFNB

promoter,and the transcription by recruiting a complex of Groucho family proteins to DNA,deleted in several B-cell non

Hodgkin lymphoma and other cancers

miRNA Products:		miRTarBase miRNAs that target PRDM1: hsa-let-7f (MIRT005514), hsa-mir-9 (MIRT001937), hsa-mir-125b (MIRT004533), hsa-let-7a (MIRT001936), hsa-let-7b (MIRT005513), hsa-mir-127-3p (MIRT004279)

		OriGene 3'-UTR Clone (see all 2): PRDM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDM1
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDM1 (see all 76):
		hsa-miR-548j hsa-miR-938 hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-4273 hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: PRDM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PRDM1
		Search LifeMap BioReagents cell lines for PRDM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS	1851123
GO:0005515	protein binding	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0042826	histone deacetylase binding	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

PRDM1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for PRDM1: Prdm1^tm1.1Liz Prdm1^tm1Rob Prdm1^tm1Masu Prdm1^tm2Rob Prdm1^tm1.1Clme Prdm1^tm2.1Liz
     14 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Prdm1):

cardiovascular system	cellular	craniofacial	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	immune system	limbs/digits/tail	mortality/aging
muscle	no phenotypic analysis	normal	reproductive system

PRDM1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Direct p53 effectors

Direct p53 effectors

1.00

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

NOD pathway

0.23

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for PRDM1

Lymphocyte Signaling

2 BioSystems Pathways for PRDM1

	NOD pathway
	Direct p53 effectors

PRDM1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PRDM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/22 Interacting proteins for PRDM1 (O75626^{2, 3} ENSP00000358092⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253²^,³, ENSP00000244769⁴	MINT-2857170 I2D: score=3 STRING: ENSP00000244769
HIST2H3A	Q71DI3³, ENSP00000385479⁴	I2D: score=1 STRING: ENSP00000385479
SUMO1	P63165², ENSP00000376076⁴	MINT-8397126 MINT-8397160 MINT-8397140 STRING: ENSP00000376076
HIST2H3C	Q71DI3³	I2D: score=1
HIST2H3D	Q71DI3³	I2D: score=1

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001701	in utero embryonic development	--	--
GO:0001892	embryonic placenta development	IEA	--
GO:0001893	maternal placenta development	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--

PRDM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PRDM1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PRDM1
3 Novoseek chemical compound relationships for PRDM1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2-methoxyestradiol	74.2	5	17877160 (3), 18192112 (2)
cytidine	68.3	4	17339456 (1), 16895557 (1), 16339522 (1)
zinc	36.1	18	14656887 (1), 11342629 (1), 19433448 (1), 16506071 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about PRDM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PRDM1 gene (2 alternative transcripts):

NM_001198.3 NM_182907.2

Unigene Cluster for PRDM1:

PR domain containing 1, with ZNF domain

Hs.436023 [show with all ESTs]

Unigene Representative Sequence: AY198414

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369091 ENST00000369096(uc003prd.2) ENST00000424894 ENST00000489365

ENST00000450060 ENST00000481163 ENST00000369089(uc003pre.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PRDM1
		8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate PRDM1 (see all 76):
		hsa-miR-548j hsa-miR-938 hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-4273 hsa-miR-4324

		SwitchGear 3'UTR luciferase reporter plasmid: PRDM1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDM1

Additional cDNA sequence:

AF084199.1 AK129768.1 AK289556.1 AK301341.1 AL832963.1 AY198414.1 AY198415.1 BC103832.1

BC103833.1 BC103834.1 BC103835.1 EF151143.1

6 DOTS entries:

DT.100751567 DT.436483 DT.100736390 DT.100751566 DT.91842415 DT.86843045

24/76 AceView cDNA sequences (see all 76):

Z38498 Z42260 BU680075 NM_001198 AA921725 AY198414 AA664123 AI269812

AA858171 NM_182907 BM710624 BQ018743 AY198415 BE219817 BX284091 AA743541

AW594160 BF516514 AI671598 BM667340 AW408568 AW188348 BE674134 AA857721

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PRDM1 (see all 10) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c
SP1:			-		-		-						-				-		-		-		-
SP2:					-		-						-				-		-		-		-
SP3:																							-
SP4:																					-		-
SP5:													-				-		-		-		-

ECgene alternative splicing isoforms for PRDM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PRDM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGCATAGC

About this image

PRDM1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epiblast

Primordial Germ Cell Precursors

Selective marker (cell-identifying gene)

Germ Cells

Eye

Neuroblastic Layer

Early Photoreceptor Precursor Cells

Photoreceptors, Retina

Eye

Neuroblastic Layer

Late Photoreceptor Precursor Cells

Photoreceptors, Retina

Placenta

Allantois

Primordial Germ Cells

Germ Cells

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Reproductive System

Early Gonad

Primordial Germ Cells

Germ Cells

Limb

Limb Bud

Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/13 LifeMap Cells (see all 13)

Name

Category

Ovarian tissue-dissociated cells (Primary Cell)

Reproductive System

Ovarian tissue-dissociated cells (human) (Primary Cell)

Ovary, Reproductive System

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

Primordial germ cell-like cells (Reconstitution of mo...)

Epiblast-like cells (Reconstitution of mo...)

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Human oogonial stem cells (Oocyte formation by ...)

See PRDM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRDM1

SOURCE GeneReport for Unigene cluster: Hs.436023

SABiosciences Custom PCR Arrays for PRDM1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRDM1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRDM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRDM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PRDM1 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PRDM1¹	PR domain containing 1, with ZNF domain	76.98(n) 79.05(a)		445340 XM_003641038.1 XP_003641086.1
lizard (Anolis carolinensis)	Reptilia	PRDM1⁶	--	77(a)	1 ↔ 1	1(189138383-189164593)
African clawed frog (Xenopus laevis)	Amphibia	prdm1-prov²	PR domain containing 1, with ZNF domain	78.22(n)		BC044261.1
zebrafish (Danio rerio)	Actinopterygii	ubo²	u-boot	77.18(n)		394229 AY497217.1
fruit fly (Drosophila melanogaster)	Insecta	CG5249³	--	72(a)		64E1 --
worm (Caenorhabditis elegans)	Secernentea	odd-3³	Zinc finger, C2H2 type (5 domains)	60(a)		I(10417413-10421900) --

ENSEMBL Gene Tree for PRDM1 (if available)
TreeFam Gene Tree for PRDM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PRDM1 gene

ZNF683² PRDM2²

18/68 SIMAP similar genes for PRDM1 using alignment to 6 protein entries: PRDM1_HUMAN (see all proteins) (see all similar genes):

DKFZp666P0310 ZNF818P DKFZp434J0650 ZNF55 ZNF78L1 ZNF

ZFS-2 ZFS-4 ZKSCAN1 zf30 A-328A3.4 ZNF468

DKFZp434G1930 DKFZp762K012 DKFZp666C237 ZNF32 ZNF83 kr-znf3

PRDM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77512532^1,2	F,	--	103979413(+)	`AGTTTG/TATTCT`	1	--	us2k¹		1		EA	120
rs61001550^1,2	C,F,	--	103979633(+)	`ACCCCC/TAGCAG`	1	--	us2k¹		4		WA CSA EA	242
rs17066563^1,2	C,F,H,	--	103979727(+)	`AGCAGC/GGAGTG`	1	--	us2k¹ tfbs³		11		NA NS EA WA CSA	804
rs76023434^1,2	F,	--	103980401(+)	`CTGGGC/GTGGAG`	1	--	us2k¹		1		NA	120
rs12195166^1,2	C,F,H	--	103980737(+)	`CAACAG/ACTTGA`	1	--	us2k¹		8		NS EA NA	1048
rs9399969^1,2	H	--	103982654(+)	`CTTTTC/TTGAGG`	1	--	int¹		4		NS EA	410
rs12526029^1,2	H	--	103982684(+)	`AGGGTC/TTGGCG`	1	--	int¹		0	--	--	--	--
rs34001545^1,2	C	--	103982828(+)	`TTTTTT/-TTTTT`	1	--	int¹		1		NA	2
rs11152961^1,2	C,A,H	--	103982989(+)	`TCTCAG/AAAGGA`	1	--	int¹		5		NS EA NA	422
rs73772586^1,2	C,F,	--	103984099(+)	`AGTTGC/TACTTA`	1	--	int¹		3		WA CSA	122

HapMap Linkage Disequilibrium report for PRDM1 (106534195 - 106557814 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PRDM1: --

3 SABiosciences Cancer Mutation PCR Assays for PRDM1:

Cosmic Id	AA Change
97170	p.P48T
97026	p.C203*
97168	p.P48R

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PRDM1 for disorders           About GeneDecksing

OMIM gene information: 603423    OMIM disorders: --

20/26 diseases for PRDM1 (see all 26):    About MalaCards

b-cell non-hodgkin lymphoma otitis media diffuse large b-cell lymphoma non-hodgkin lymphoma

neuromyelitis optica central nervous system lymphoma b-cell lymphomas common variable immunodeficiency

hodgkin's lymphoma devic disease mantle cell lymphoma plasmacytoma

systemic lupus erythematosus lupus erythematosus adult t-cell leukemia germ cell tumor

multiple myeloma t-cell leukemia rheumatoid arthritis myeloma

1 disease from the University of Copenhagen DISEASES database for PRDM1:

Lymphoma

9 Novoseek disease relationships for PRDM1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma b-cell	55.7	15	17213024 (4), 16585013 (3), 19380033 (2), 18596541 (1) (see all 6)
plasmacytoma	51.2	3	18089822 (2)
lymphoma	50.7	12	17682124 (1), 11067898 (1), 16778825 (1), 8168136 (1) (see all 11)
myeloma	50.3	8	15195108 (2), 16982896 (1), 18192112 (1), 17877160 (1) (see all 6)
lymphoma large cell diffuse	41.6	1	16492805 (1)
virus infection	3.17	6	19664943 (3), 16708403 (1), 14985713 (1)
hodgkin disease	0.852	1	16585013 (1)
leukemia	0	3	11841448 (1), 8921366 (1)
tumors	0	10	16585013 (2), 20047096 (2), 16492805 (2), 18596541 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: PRDM1 (13 documents)

Export disorders for PRDM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PRDM1 gene, integrated from 9 sources (see all 170):
(articles sorted by number of sources associating them with PRDM1)

Utopia: connect your pdf to the dynamic
world of online information

Identification and characterization of a novel repressor of beta- interferon gene expression. (PubMed id 1851123)^{1, 2, 3, 9} Keller A.D. and Maniatis T. (1991)
Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. (PubMed id 12626569)^{1, 2, 9} Gyory I.... Wright K.L. (2003)
SUMOylation of Blimp-1 is critical for plasma cell dif ferentiation. (PubMed id 22555612)^{1, 2} Ying H.Y....Lin K.I. (2012)
Regulation and functions of Blimp-1 in T and B lymphocytes. (PubMed id 18370921)^{1, 9} Martins G. and Calame K. (2008)
Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown. (PubMed id 18089822)^{1, 9} Lin F.R....Lin K.I. (2007)
Human BSAP and BLIMP1 conform an autoregulatory feedback loop. (PubMed id 17682124)^{1, 9} Mora-Lopez F....Campos-Caro A. (2007)
Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase. (PubMed id 10713181)^{1, 9} Yu J....Calame K. (2000)
Blimp-1 is a tumor suppressor gene in lymphoid malign ancies. (PubMed id 20047096)^{1, 9} Hangaishi A. and Kurokawa M. (2010)
Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. (PubMed id 16492805)^{1, 9} Pasqualucci L....Dalla-Favera R. (2006)
Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. (PubMed id 11067898)^{1, 9} Angelin-Duclos C....Calame K. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 639	HGNC: 9346	AceView: PRDM1	Ensembl:ENSG00000057657	euGenes: HUgn639
ECgene: PRDM1	H-InvDB: PRDM1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PRDM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for PRDM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PRDM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PRDM1 gene:
Search GeneIP for patents involving PRDM1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PR domain containing 1, with ZNF domain

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PR domain containing 1, with ZNF domain

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