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Aliases for PRCP Gene

Aliases for PRCP Gene

  • Prolylcarboxypeptidase 2 3 4 5
  • Angiotensinase C 2 3 4
  • Prolylcarboxypeptidase (Angiotensinase C) 2 3
  • Lysosomal Carboxypeptidase C 3 4
  • Proline Carboxypeptidase 3 4
  • EC 3.4.16.2 4 63
  • PCP 3 4
  • HUMPCP 3

External Ids for PRCP Gene

Previous GeneCards Identifiers for PRCP Gene

  • GC11M084862
  • GC11M084074
  • GC11M082261
  • GC11M082213
  • GC11M082535
  • GC11M078832

Summaries for PRCP Gene

Entrez Gene Summary for PRCP Gene

  • This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRCP Gene

PRCP (Prolylcarboxypeptidase) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade). GO annotations related to this gene include serine-type peptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is DPP7.

UniProtKB/Swiss-Prot for PRCP Gene

  • Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene Wiki entry for PRCP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRCP Gene

Genomics for PRCP Gene

Regulatory Elements for PRCP Gene

Genomic Location for PRCP Gene

Chromosome:
11
Start:
82,823,502 bp from pter
End:
82,970,584 bp from pter
Size:
147,083 bases
Orientation:
Minus strand

Genomic View for PRCP Gene

Genes around PRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCP Gene

Proteins for PRCP Gene

  • Protein details for PRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42785-PCP_HUMAN
    Recommended name:
    Lysosomal Pro-X carboxypeptidase
    Protein Accession:
    P42785
    Secondary Accessions:
    • A8MU24
    • B2R7B7
    • B3KRK5
    • B5BU34

    Protein attributes for PRCP Gene

    Size:
    496 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PRCP Gene

    Alternative splice isoforms for PRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRCP Gene

Proteomics data for PRCP Gene at MOPED

Selected DME Specific Peptides for PRCP Gene

Post-translational modifications for PRCP Gene

  • Ubiquitination at Lys 77
  • Glycosylation at Thr 39, Asn 47, Asn 101, Asn 317, Asn 336, Asn 345, and Asn 415
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PRCP (Lysosomal Pro-X Carboxypeptidase/PRCP)

Domains & Families for PRCP Gene

Gene Families for PRCP Gene

Protein Domains for PRCP Gene

Suggested Antigen Peptide Sequences for PRCP Gene

Graphical View of Domain Structure for InterPro Entry

P42785

UniProtKB/Swiss-Prot:

PCP_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRCP: view

Function for PRCP Gene

Molecular function for PRCP Gene

GENATLAS Biochemistry:
angiotensinase C,51kDa,lysosomal
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of a -Pro- -Xaa bond to release a C-terminal amino acid.
UniProtKB/Swiss-Prot Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Enzyme Numbers (IUBMB) for PRCP Gene

Gene Ontology (GO) - Molecular Function for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008239 dipeptidyl-peptidase activity IBA --
genes like me logo Genes that share ontologies with PRCP: view
genes like me logo Genes that share phenotypes with PRCP: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRCP Gene

Localization for PRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCP Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRCP Gene COMPARTMENTS Subcellular localization image for PRCP gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045178 basal part of cell IEA --
genes like me logo Genes that share ontologies with PRCP: view

Pathways & Interactions for PRCP Gene

genes like me logo Genes that share pathways with PRCP: view

Pathways by source for PRCP Gene

Gene Ontology (GO) - Biological Process for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002353 plasma kallikrein-kinin cascade IEA --
GO:0007596 blood coagulation TAS --
GO:0060055 angiogenesis involved in wound healing IEA,IBA --
GO:2000377 regulation of reactive oxygen species metabolic process IEA --
genes like me logo Genes that share ontologies with PRCP: view

No data available for SIGNOR curated interactions for PRCP Gene

Drugs & Compounds for PRCP Gene

(4) Drugs for PRCP Gene - From: ApexBio, Novoseek, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benazepril Approved, Investigational Pharma 45
Angiotensin III (human, mouse) Pharma Aldosterone stimulator 0

(3) Additional Compounds for PRCP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRCP: view

Transcripts for PRCP Gene

Unigene Clusters for PRCP Gene

Prolylcarboxypeptidase (angiotensinase C):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRCP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for PRCP Gene

GeneLoc Exon Structure for
PRCP
ECgene alternative splicing isoforms for
PRCP

Expression for PRCP Gene

mRNA expression in normal human tissues for PRCP Gene

mRNA differential expression in normal tissues according to GTEx for PRCP Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for PRCP Gene

This gene is overexpressed in NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRCP Gene



SOURCE GeneReport for Unigene cluster for PRCP Gene Hs.523936

mRNA Expression by UniProt/SwissProt for PRCP Gene

P42785-PCP_HUMAN
Tissue specificity: Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
genes like me logo Genes that share expression patterns with PRCP: view

Protein tissue co-expression partners for PRCP Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRCP Gene

Orthologs for PRCP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRCP 35
  • 99.73 (n)
  • 99.4 (a)
PRCP 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRCP 36
  • 78 (a)
OneToOne
PRCP 35
  • 85.11 (n)
  • 78.5 (a)
dog
(Canis familiaris)
Mammalia PRCP 35
  • 86.22 (n)
  • 80.24 (a)
PRCP 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prcp 16
Prcp 36
  • 77 (a)
OneToOne
Prcp 35
  • 82 (n)
  • 78.12 (a)
oppossum
(Monodelphis domestica)
Mammalia PRCP 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRCP 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prcp 35
  • 81.7 (n)
  • 78.5 (a)
chicken
(Gallus gallus)
Aves PRCP 35
  • 67.81 (n)
  • 67.17 (a)
PRCP 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRCP 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32860 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prcp 35
  • 67.2 (n)
  • 69.93 (a)
zebrafish
(Danio rerio)
Actinopterygii prcp 35
  • 63.38 (n)
  • 62.96 (a)
prcp 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000994 35
  • 52.68 (n)
  • 48.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2493 37
  • 46 (a)
CG2493 35
  • 52.95 (n)
  • 48.05 (a)
CG2493 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pcp-1 36
  • 32 (a)
OneToMany
pcp-5 36
  • 35 (a)
OneToMany
pcp-5 35
  • 51.07 (n)
  • 43.15 (a)
F56F10.1 37
  • 27 (a)
K12H4.7b 37
  • 24 (a)
ZK688.6a 37
  • 40 (a)
ZK688.6b 37
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65760 35
  • 52.69 (n)
  • 47 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11612 35
rice
(Oryza sativa)
Liliopsida Os01g0767100 35
  • 53.41 (n)
  • 47.82 (a)
Species with no ortholog for PRCP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRCP Gene

ENSEMBL:
Gene Tree for PRCP (if available)
TreeFam:
Gene Tree for PRCP (if available)

Paralogs for PRCP Gene

Paralogs for PRCP Gene

Pseudogenes.org Pseudogenes for PRCP Gene

genes like me logo Genes that share paralogs with PRCP: view

Variants for PRCP Gene

Sequence variations from dbSNP and Humsavar for PRCP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_020464 -
VAR_029329 -
rs615421 -- 82,866,670(+) AACAC(A/C)ATAGC intron-variant
rs631224 -- 82,889,212(-) cctgg(A/C)tattt intron-variant
rs1783870 -- 82,871,082(+) TCATC(A/C)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRCP Gene

Variant ID Type Subtype PubMed ID
esv33531 CNV Loss 17666407
nsv898016 CNV Loss 21882294
nsv515868 CNV Gain 19592680
esv2290101 CNV Deletion 18987734
esv2673057 CNV Deletion 23128226
nsv38781 CNV Loss 16902084

Variation tolerance for PRCP Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRCP Gene

HapMap Linkage Disequilibrium report
PRCP
Human Gene Mutation Database (HGMD)
PRCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCP Gene

Disorders for PRCP Gene

Relevant External Links for PRCP

Genetic Association Database (GAD)
PRCP
Human Genome Epidemiology (HuGE) Navigator
PRCP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRCP

No disorders were found for PRCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRCP Gene

Publications for PRCP Gene

  1. Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families. (PMID: 8344943) Tan F. … Erdoes E.G. (J. Biol. Chem. 1993) 2 3 4 23 67
  2. Expression, purification and crystallization of human prolylcarboxypeptidase. (PMID: 20516604) Abeywickrema P.D. … Sharma S. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23
  3. E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. (PMID: 20079160) Zhang Y. … Xu X.P. (Chin. Med. J. 2009) 3 23
  4. Prolylcarboxypeptidase: a cardioprotective enzyme. (PMID: 18396440) Mallela J. … Shariat-Madar Z. (Int. J. Biochem. Cell Biol. 2009) 3 23
  5. The functional importance of the N-terminal region of human prolylcarboxypeptidase. (PMID: 18656443) Mallela J. … Shariat-Madar Z. (Biochem. Biophys. Res. Commun. 2008) 3 23

Products for PRCP Gene

Sources for PRCP Gene

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