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Aliases for PRCP Gene

Aliases for PRCP Gene

  • Prolylcarboxypeptidase 2 3 4 5
  • Angiotensinase C 2 3 4
  • Lysosomal Carboxypeptidase C 3 4
  • Proline Carboxypeptidase 3 4
  • EC 3.4.16.2 4 61
  • PCP 3 4
  • Prolylcarboxypeptidase (Angiotensinase C) 2
  • Lysosomal Pro-X Carboxypeptidase 3
  • HUMPCP 3

External Ids for PRCP Gene

Previous GeneCards Identifiers for PRCP Gene

  • GC11M084862
  • GC11M084074
  • GC11M082261
  • GC11M082213
  • GC11M082535
  • GC11M078832

Summaries for PRCP Gene

Entrez Gene Summary for PRCP Gene

  • This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

GeneCards Summary for PRCP Gene

PRCP (Prolylcarboxypeptidase) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Innate Immune System. GO annotations related to this gene include serine-type peptidase activity and serine-type carboxypeptidase activity. An important paralog of this gene is DPP7.

UniProtKB/Swiss-Prot for PRCP Gene

  • Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Gene Wiki entry for PRCP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRCP Gene

Genomics for PRCP Gene

Regulatory Elements for PRCP Gene

Enhancers for PRCP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G082899 1.7 FANTOM5 ENCODE dbSUPER 14.1 +69.6 69629 3.8 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DDIAS PRCP PCF11 ENSG00000254676 ANKRD42 RAB30 RPL7AP54
GH11G082867 1.2 Ensembl ENCODE dbSUPER 18.9 +103.0 103025 0.9 CTCF ZNF654 ZNF362 RB1 HLF TRIM22 ZNF384 REST RAD21 SMC3 DDIAS PRCP FAM181B CCDC90B LOC102724712 RAB30 ENSG00000254441
GH11G082922 0.7 ENCODE dbSUPER 25.9 +47.6 47564 0.8 GATA3 ESRRA GATA2 PRCP DDIAS RAB30 RAB30-AS1 RPL7AP54
GH11G082895 1.1 Ensembl ENCODE dbSUPER 14 +74.7 74705 1.0 PKNOX1 ZNF10 JUNB GATA3 ZBTB48 GATA2 PBX2 PRDM1 PRCP DDIAS ENSG00000254441
GH11G082888 1.2 Ensembl ENCODE dbSUPER 12.5 +80.0 80025 3.3 HDGF PKNOX1 TAL1 JUN ZBTB40 GATA2 ETV6 L3MBTL2 MTA2 HLF DDIAS PRCP RAB30 RAB30-AS1 ENSG00000254441
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRCP on UCSC Golden Path with GeneCards custom track

Genomic Location for PRCP Gene

Chromosome:
11
Start:
82,823,502 bp from pter
End:
82,970,584 bp from pter
Size:
147,083 bases
Orientation:
Minus strand

Genomic View for PRCP Gene

Genes around PRCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCP Gene

Proteins for PRCP Gene

  • Protein details for PRCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42785-PCP_HUMAN
    Recommended name:
    Lysosomal Pro-X carboxypeptidase
    Protein Accession:
    P42785
    Secondary Accessions:
    • A8MU24
    • B2R7B7
    • B3KRK5
    • B5BU34

    Protein attributes for PRCP Gene

    Size:
    496 amino acids
    Molecular mass:
    55800 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for PRCP Gene

    Alternative splice isoforms for PRCP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRCP Gene

Selected DME Specific Peptides for PRCP Gene

P42785:
  • LTSEQALAD
  • QKVDHFGF
  • GGSYGGMLAAWFRMKYPH
  • KAMLVFAEHRYYGESLPFG
  • NTGFMWD

Post-translational modifications for PRCP Gene

  • Ubiquitination at posLast=7777
  • Glycosylation at Thr39, posLast=4747, Asn101, posLast=317317, Asn336, Asn345, and posLast=415415
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for PRCP (Lysosomal Pro-X Carboxypeptidase/PRCP)
  • Abcam antibodies for PRCP

Domains & Families for PRCP Gene

Protein Domains for PRCP Gene

Suggested Antigen Peptide Sequences for PRCP Gene

Graphical View of Domain Structure for InterPro Entry

P42785

UniProtKB/Swiss-Prot:

PCP_HUMAN :
  • Belongs to the peptidase S28 family.
Family:
  • Belongs to the peptidase S28 family.
genes like me logo Genes that share domains with PRCP: view

Function for PRCP Gene

Molecular function for PRCP Gene

GENATLAS Biochemistry:
angiotensinase C,51kDa,lysosomal
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of a -Pro- -Xaa bond to release a C-terminal amino acid.
UniProtKB/Swiss-Prot Function:
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Enzyme Numbers (IUBMB) for PRCP Gene

Gene Ontology (GO) - Molecular Function for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004180 carboxypeptidase activity IEA --
GO:0004185 serine-type carboxypeptidase activity TAS --
GO:0005515 protein binding IPI 20517885
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with PRCP: view
genes like me logo Genes that share phenotypes with PRCP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRCP

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRCP Gene

Localization for PRCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCP Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRCP gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005886 plasma membrane TAS --
GO:0035577 azurophil granule membrane TAS --
GO:0045178 basal part of cell IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PRCP: view

Pathways & Interactions for PRCP Gene

genes like me logo Genes that share pathways with PRCP: view

Gene Ontology (GO) - Biological Process for PRCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002155 regulation of thyroid hormone mediated signaling pathway IEA --
GO:0002353 plasma kallikrein-kinin cascade IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006508 proteolysis IEA --
GO:0007597 blood coagulation, intrinsic pathway TAS --
genes like me logo Genes that share ontologies with PRCP: view

No data available for SIGNOR curated interactions for PRCP Gene

Drugs & Compounds for PRCP Gene

(4) Drugs for PRCP Gene - From: PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benazepril Approved, Investigational Pharma 45
Angiotensin III (human, mouse) Pharma Aldosterone stimulator 0

(3) Additional Compounds for PRCP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for PRCP Gene

Compound Action Cas Number
Angiotensin III (human, mouse) Aldosterone stimulator 13602-53-4
genes like me logo Genes that share compounds with PRCP: view

Drug Products

Transcripts for PRCP Gene

Unigene Clusters for PRCP Gene

Prolylcarboxypeptidase (angiotensinase C):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRCP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - -
SP2: - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for PRCP Gene

GeneLoc Exon Structure for
PRCP
ECgene alternative splicing isoforms for
PRCP

Expression for PRCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRCP Gene

mRNA differential expression in normal tissues according to GTEx for PRCP Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for PRCP Gene

This gene is overexpressed in NK cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRCP Gene



Protein tissue co-expression partners for PRCP Gene

NURSA nuclear receptor signaling pathways regulating expression of PRCP Gene:

PRCP

SOURCE GeneReport for Unigene cluster for PRCP Gene:

Hs.523936

mRNA Expression by UniProt/SwissProt for PRCP Gene:

P42785-PCP_HUMAN
Tissue specificity: Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.

Evidence on tissue expression from TISSUES for PRCP Gene

  • Nervous system(4.8)
  • Kidney(4.5)
  • Liver(4.4)
  • Lung(4.4)
  • Heart(2.6)
  • Blood(2.4)
genes like me logo Genes that share expression patterns with PRCP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRCP Gene

Orthologs for PRCP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRCP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRCP 34 35
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia PRCP 34 35
  • 86.22 (n)
cow
(Bos Taurus)
Mammalia PRCP 34 35
  • 85.11 (n)
mouse
(Mus musculus)
Mammalia Prcp 34 16 35
  • 82 (n)
rat
(Rattus norvegicus)
Mammalia Prcp 34
  • 81.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRCP 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRCP 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRCP 35 34
  • 67.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRCP 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prcp 34
  • 67.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32860 34
zebrafish
(Danio rerio)
Actinopterygii prcp 34 35
  • 63.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2493 36 34 35
  • 52.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000994 34
  • 52.68 (n)
worm
(Caenorhabditis elegans)
Secernentea pcp-5 35 34
  • 51.07 (n)
OneToMany
ZK688.6a 36
  • 40 (a)
ZK688.6b 36
  • 40 (a)
pcp-1 35
  • 32 (a)
OneToMany
F56F10.1 36
  • 27 (a)
K12H4.7b 36
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65760 34
  • 52.69 (n)
rice
(Oryza sativa)
Liliopsida Os01g0767100 34
  • 53.41 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.11612 34
Species where no ortholog for PRCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRCP Gene

ENSEMBL:
Gene Tree for PRCP (if available)
TreeFam:
Gene Tree for PRCP (if available)

Paralogs for PRCP Gene

Paralogs for PRCP Gene

Pseudogenes.org Pseudogenes for PRCP Gene

genes like me logo Genes that share paralogs with PRCP: view

Variants for PRCP Gene

Sequence variations from dbSNP and Humsavar for PRCP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000074086 -- 82,893,324(+) AGTGA(A/C)CGAAA intron-variant
rs1000087398 -- 82,869,428(+) AAAGC(A/G)GTATA intron-variant
rs1000099422 -- 82,830,767(+) CTACA(C/T)AAGGA intron-variant
rs1000222440 -- 82,834,226(+) TGTTT(A/G)TATAT intron-variant
rs1000224229 -- 82,869,095(+) TCACA(C/G)CTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRCP Gene

Variant ID Type Subtype PubMed ID
dgv2038n54 CNV loss 21841781
esv2290101 CNV deletion 18987734
esv2673057 CNV deletion 23128226
esv33531 CNV loss 17666407
esv3548070 CNV deletion 23714750
esv3579916 CNV gain 25503493
esv3627005 CNV loss 21293372
esv3627006 CNV loss 21293372
nsv1113415 CNV deletion 24896259
nsv38781 CNV deletion 16902084
nsv515868 CNV gain 19592680
nsv555602 CNV gain 21841781
nsv951048 CNV duplication 24416366

Variation tolerance for PRCP Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRCP Gene

Human Gene Mutation Database (HGMD)
PRCP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRCP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCP Gene

Disorders for PRCP Gene

Relevant External Links for PRCP

Genetic Association Database (GAD)
PRCP
Human Genome Epidemiology (HuGE) Navigator
PRCP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRCP

No disorders were found for PRCP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRCP Gene

Publications for PRCP Gene

  1. Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families. (PMID: 8344943) Tan F. … Erdoes E.G. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. (PMID: 20079160) Zhang Y. … Xu X.P. (Chin. Med. J. 2009) 3 22 46 64
  3. Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia. (PMID: 16681991) Wang L. … Wang X. (Am. J. Obstet. Gynecol. 2006) 3 22 46 64
  4. Expression, purification and crystallization of human prolylcarboxypeptidase. (PMID: 20516604) Abeywickrema P.D. … Sharma S. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 22 64
  5. Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase. (PMID: 20540760) Soisson S.M. … Lumb K.J. (BMC Struct. Biol. 2010) 3 4 64

Products for PRCP Gene

Sources for PRCP Gene

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