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Aliases for PRCC Gene

Aliases for PRCC Gene

  • Papillary Renal Cell Carcinoma (Translocation-Associated) 2 3 5
  • Papillary Renal Cell Carcinoma Translocation-Associated Gene Protein 3 4
  • TPRC 3 4
  • Proline-Rich Protein PRCC 3
  • RCCP1 3

External Ids for PRCC Gene

Previous GeneCards Identifiers for PRCC Gene

  • GC01P154606
  • GC01P152502
  • GC01P153515
  • GC01P153954
  • GC01P153550
  • GC01P155003
  • GC01P128095

Summaries for PRCC Gene

Entrez Gene Summary for PRCC Gene

  • This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

GeneCards Summary for PRCC Gene

PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated)) is a Protein Coding gene. Diseases associated with PRCC include Renal Cell Carcinoma, Papillary and Renal Cell Carcinoma. Among its related pathways are Transcriptional misregulation in cancer and Gene Expression.

UniProtKB/Swiss-Prot for PRCC Gene

  • May regulate cell cycle progression through interaction with MAD2L2.

Gene Wiki entry for PRCC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRCC Gene

Genomics for PRCC Gene

Regulatory Elements for PRCC Gene

Enhancers for PRCC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G156689 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -58.6 -58611 6.0 CREB3L1 MLX ZFP64 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 MCM3 KIAA0907 RRNAD1 MSTO2P LOC246784 BGLAP SYT11 LOC105371453 BCAN ISG20L2 HDGF
GH01G156797 1.1 ENCODE 10.9 +46.9 46874 0.2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF766 ZNF143 MRPL24 INSRR PEAR1 LRRC71 HDGF PRCC ENSG00000223356 RRNAD1 ISG20L2 GC01P156814
GH01G156696 0.7 dbSUPER 10.3 -53.1 -53119 2.0 CBX3 CEBPG ZIC2 ZNF48 ZNF664 ZNF335 GLIS2 POLR2A ZNF600 ZNF740 NES LOC105371453 BCAN ISG20L2 RRNAD1 HDGF PRCC NAXE CRABP2 ENSG00000237588
GH01G156852 0.7 ENCODE 9.8 +101.9 101944 0.1 KLF1 NFIB KLF17 THRB FOSL1 ZNF3 NFIA REST FOXA1 NR2F2 PEAR1 LRRC71 ENSG00000223356 HDGF MRPL24 MIR765 ARHGEF11 PRCC C1orf61 MIR9-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRCC on UCSC Golden Path with GeneCards custom track

Promoters for PRCC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PRCC Gene

156,750,610 bp from pter
156,800,817 bp from pter
50,208 bases
Plus strand

Genomic View for PRCC Gene

Genes around PRCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCC Gene

Proteins for PRCC Gene

  • Protein details for PRCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline-rich protein PRCC
    Protein Accession:
    Secondary Accessions:
    • A8K1F7
    • O00665
    • O00724
    • Q5SZ06

    Protein attributes for PRCC Gene

    491 amino acids
    Molecular mass:
    52418 Da
    Quaternary structure:
    • Interacts with MAD2L2; the interaction is direct.

neXtProt entry for PRCC Gene

Post-translational modifications for PRCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRCC Gene

No data available for DME Specific Peptides for PRCC Gene

Domains & Families for PRCC Gene

Protein Domains for PRCC Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRCC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRCC Gene

Function for PRCC Gene

Molecular function for PRCC Gene

UniProtKB/Swiss-Prot Function:
May regulate cell cycle progression through interaction with MAD2L2.

Gene Ontology (GO) - Molecular Function for PRCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11717438
genes like me logo Genes that share ontologies with PRCC: view
genes like me logo Genes that share phenotypes with PRCC: view

Human Phenotype Ontology for PRCC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for PRCC Gene

miRTarBase miRNAs that target PRCC

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PRCC Gene

Localization for PRCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRCC gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11717438
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with PRCC: view

Pathways & Interactions for PRCC Gene

genes like me logo Genes that share pathways with PRCC: view

Pathways by source for PRCC Gene

SIGNOR curated interactions for PRCC Gene


Gene Ontology (GO) - Biological Process for PRCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0007049 cell cycle IEA --
GO:0007093 mitotic cell cycle checkpoint IDA 11717438
genes like me logo Genes that share ontologies with PRCC: view

Drugs & Compounds for PRCC Gene

No Compound Related Data Available

Transcripts for PRCC Gene

Unigene Clusters for PRCC Gene

Papillary renal cell carcinoma (translocation-associated):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRCC Gene

No ASD Table

Relevant External Links for PRCC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRCC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRCC Gene

Protein differential expression in normal tissues from HIPED for PRCC Gene

This gene is overexpressed in Adrenal (42.2) and Liver (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRCC Gene

Protein tissue co-expression partners for PRCC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRCC Gene:


SOURCE GeneReport for Unigene cluster for PRCC Gene:


mRNA Expression by UniProt/SwissProt for PRCC Gene:

Tissue specificity: Ubiquitous in fetal and adult tissues.

Evidence on tissue expression from TISSUES for PRCC Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Liver(4.2)
  • Blood(4.1)
  • Eye(2.8)
  • Kidney(2.8)
  • Lymph node(2.1)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRCC Gene

Germ Layers:
  • mesoderm
  • urinary
  • kidney
genes like me logo Genes that share expression patterns with PRCC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRCC Gene

Orthologs for PRCC Gene

This gene was present in the common ancestor of animals.

Orthologs for PRCC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRCC 34 35
  • 99.73 (n)
(Bos Taurus)
Mammalia PRCC 34 35
  • 93.75 (n)
(Canis familiaris)
Mammalia PRCC 34 35
  • 91.89 (n)
(Rattus norvegicus)
Mammalia Prcc 34
  • 90.25 (n)
(Mus musculus)
Mammalia Prcc 34 16 35
  • 89.23 (n)
(Monodelphis domestica)
Mammalia PRCC 35
  • 87 (a)
(Gallus gallus)
Aves PRCC 34 35
  • 74.41 (n)
(Anolis carolinensis)
Reptilia PRCC 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia prcc 34
  • 68.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10563 34
(Danio rerio)
Actinopterygii prcc 34 35
  • 60.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17249 35
  • 25 (a)
Species where no ortholog for PRCC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRCC Gene

Gene Tree for PRCC (if available)
Gene Tree for PRCC (if available)

Paralogs for PRCC Gene

No data available for Paralogs for PRCC Gene

Variants for PRCC Gene

Sequence variations from dbSNP and Humsavar for PRCC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000093462 -- 156,799,626(+) GTTTG(C/T)AGGGA intron-variant
rs1000155101 -- 156,785,598(+) GGGGA(A/G)AAAAA intron-variant
rs1000176720 -- 156,786,447(+) CAAGC(C/T)CAGAT intron-variant
rs1000357472 -- 156,793,235(+) TCTTT(C/G)GGAAC intron-variant
rs1000371192 -- 156,792,899(+) AATAC(C/T)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRCC Gene

Variant ID Type Subtype PubMed ID
nsv1120200 CNV tandem duplication 24896259
nsv831648 CNV loss 17160897
nsv831659 CNV loss 17160897

Variation tolerance for PRCC Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.75; 78.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRCC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCC Gene

Disorders for PRCC Gene

MalaCards: The human disease database

(7) MalaCards diseases for PRCC Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
  • njovera
epithelial predominant wilms' tumor
  • epithelial predominant kidney adenosarcoma
mucinous tubular and spindle renal cell carcinoma
  • mucinous tubular and spindle cell renal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PRCC in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3. {ECO:0000269 PubMed:8872474, ECO:0000269 PubMed:8986805}.

Relevant External Links for PRCC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRCC: view

No data available for Genatlas for PRCC Gene

Publications for PRCC Gene

  1. The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. (PMID: 8872474) Sidhar S.K. … Cooper C.S. (Hum. Mol. Genet. 1996) 2 3 4 22 64
  2. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. (PMID: 11717438) Weterman M.A. … van Kessel A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 22 64
  3. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. (PMID: 8986805) Weterman M.A.J. … Geurts van Kessel A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for PRCC Gene

Sources for PRCC Gene

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