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PRCC Gene

protein-coding   GIFtS: 54
GCID: GC01P156720

Papillary Renal Cell Carcinoma (Translocation-Associated)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Papillary Renal Cell Carcinoma (Translocation-Associated)1 2
Papillary Renal Cell Carcinoma Translocation-Associated Gene Protein2 3
TPRC2 3
RCCP12 5
Proline-Rich Protein PRCC2

External Ids:    HGNC: 93431   Entrez Gene: 55462   Ensembl: ENSG000001432947   OMIM: 1797555   UniProtKB: Q927333   

Export aliases for PRCC gene to outside databases

Previous GC identifers: GC01P154606 GC01P152502 GC01P153515 GC01P153954 GC01P153550 GC01P155003 GC01P128095


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRCC Gene:
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21)
that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell
carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered
gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.(provided by
RefSeq, Aug 2010)

GeneCards Summary for PRCC Gene:
PRCC (papillary renal cell carcinoma (translocation-associated)) is a protein-coding gene. Diseases associated with PRCC include papillary renal cell carcinoma, and renal cell carcinoma, papillary, 1.

UniProtKB/Swiss-Prot: PRCC_HUMAN, Q92733
Function: May regulate cell cycle progression through interaction with MAD2L2

Gene Wiki entry for PRCC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRCC gene promoter:
         HOXA9   Spz1   AML1a   Pax-5   FOXO4   Nkx2-5   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PRCC promoter sequence
   Search Chromatin IP Primers for PRCC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21.1

PRCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRCC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156720:  view genomic region     (about GC identifiers)

Start:
156,720,402 bp from pter      End:
156,770,609 bp from pter
Size:
50,208 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRCC_HUMAN, Q92733 (See protein sequence)
Recommended Name: Proline-rich protein PRCC  
Size: 491 amino acids; 52418 Da
Subunit: Interacts with MAD2L2; the interaction is direct
Secondary accessions: A8K1F7 O00665 O00724 Q5SZ06

Explore the universe of human proteins at neXtProt for PRCC: NX_Q92733

Explore proteomics data for PRCC at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRCC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005964.3  
    ENSEMBL proteins: 
     ENSP00000271526   ENSP00000434762   ENSP00000403560   ENSP00000339300  

    PRCC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for PRCC
    OriGene Protein Over-expression Lysate for PRCC
    OriGene MassSpec for PRCC
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    Novus Biologicals PRCC Protein
    Novus Biologicals PRCC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PRCC

    PRCC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRCC
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PRCC
    OriGene Custom Antibody Services for PRCC
    Novus Biologicals PRCC Antibodies
    Abcam antibodies for PRCC
    Cloud-Clone Corp. Antibodies for PRCC
    Search ThermoFisher Antibodies for PRCC
    Search LSBio for Antibodies for PRCC

    PRCC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PRCC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PRCC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PRCC
    Cloud-Clone Corp. CLIAs for PRCC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018800 PRCC

    Graphical View of Domain Structure for InterPro Entry Q92733

    ProtoNet protein and cluster: Q92733


    PRCC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRCC_HUMAN, Q92733
    Function: May regulate cell cycle progression through interaction with MAD2L2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11717438
         
    PRCC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRCC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PRCC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRCC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRCC

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRCC:
    hsa-mir-877-5p (MIRT037286), hsa-mir-18a-3p (MIRT040762), hsa-mir-421 (MIRT039451)

    Block miRNA regulation of human, mouse, rat PRCC using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PRCC:
    hsa-miR-615-5p hsa-miR-3658 hsa-miR-548c-3p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidPRCC 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PRCC
    Predesigned siRNA for gene silencing in human, mouse, rat PRCC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PRCC

    Clone
    Products:
         
    OriGene clones in human, mouse for PRCC (see all 9)
    OriGene ORF clones in mouse, rat for PRCC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRCC (NM_005973)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRCC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRCC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PRCC
    Browse ESI BIO Cell Lines and PureStem Progenitors for PRCC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRCC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRCC_HUMAN, Q92733: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    PRCC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRCC About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for PRCC):
        Transcriptional misregulation in cancer


    PRCC for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRCC
    Interactions:

        GeneGlobe Interaction Network for PRCC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PRCC (Q927332, 3 ENSP000002715264) via UniProtKB, MINT, STRING, and/or I2D (see all 565)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206007 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    PRPF19Q9UMS42, ENSP000002275244MINT-8336716 MINT-7947479 STRING: ENSP00000227524
    EGFRP005333, ENSP000002754934I2D: score=2 STRING: ENSP00000275493
    MAD2L2Q9UI953, ENSP000002353104I2D: score=1 STRING: ENSP00000235310
    PPIL2Q133562, ENSP000003904274MINT-8336980 STRING: ENSP00000390427
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007093mitotic cell cycle checkpoint IDA11717438

    PRCC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRCC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRCC gene (2 alternative transcripts): 
    NM_005973.4  NM_199416.1  

    Unigene Cluster for PRCC:

    Papillary renal cell carcinoma (translocation-associated)
    Hs.516948  [show with all ESTs]
    Unigene Representative Sequence: NM_005973
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491853 ENST00000271526(uc001fqa.3) ENST00000473387 ENST00000526188
    ENST00000454659 ENST00000459707 ENST00000469071 ENST00000353233
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PRCC using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate PRCC:
    hsa-miR-615-5p hsa-miR-3658 hsa-miR-548c-3p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidPRCC 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PRCC
    Predesigned siRNA for gene silencing in human, mouse, rat PRCC
    Clone
    Products:
         
    OriGene clones in human, mouse for PRCC (see all 9)
    OriGene ORF clones in mouse, rat for PRCC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PRCC (NM_005973)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRCC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRCC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PRCC
    OriGene qSTAR qPCR primer pairs in human, mouse for PRCC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PRCC
      QuantiTect SYBR Green Assays in human, mouse, rat PRCC
      QuantiFast Probe-based Assays in human, mouse, rat PRCC

    Additional mRNA sequence: 

    AK289872.1 BC004913.2 BC010450.1 S69270.1 X97124.1 

    15 DOTS entries:

    DT.100753402  DT.455291  DT.100651982  DT.100651989  DT.92448460  DT.121434729  DT.95348107  DT.95377771 
    DT.40212056  DT.92448456  DT.100651978  DT.40132605  DT.100651983  DT.92448458  DT.95377508 

    Selected AceView cDNA sequences (see all 397):

    BU508102 BQ675403 BG481089 NM_199416 CB156430 BM693421 CR592335 BE794554 
    BQ435179 BU625699 CB305348 BM800297 NM_005973 BU931626 AL546958 BQ686550 
    AI887467 BM853432 CA393199 CR593687 AA620351 AI160241 BQ962348 BM759695 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRCC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCATTCA
    PRCC Expression
    About this image


    PRCC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    PRCC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRCC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516948

    UniProtKB/Swiss-Prot: PRCC_HUMAN, Q92733
    Tissue specificity: Ubiquitous in fetal and adult tissues

        Custom PCR Arrays for PRCC
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat PRCC
    QuantiFast Probe-based Assays in human, mouse, rat PRCC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRCC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRCC gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prcc1 , 5 papillary renal cell carcinoma (translocation-associated)1, 5 89.23(n)1
    93.25(a)1
      3 (38.78 cM)5
    943151  NM_033573.21  NP_291051.11 
     878589005 
    chicken
    (Gallus gallus)
    Aves PRCC1 papillary renal cell carcinoma (translocation-associated) 74.41(n)
    78.75(a)
      425977  XM_423657.4  XP_423657.2 
    lizard
    (Anolis carolinensis)
    Reptilia PRCC6
    papillary renal cell carcinoma (translocation-asso...
    66(a)
    1 ↔ 1
    GL343637.1(84596-95869)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.105632 Xenopus laevis mRNA for papillary renal cell carcinoma more 78.48(n)    AJ318531.1 
    zebrafish
    (Danio rerio)
    Actinopterygii prcc1 papillary renal cell carcinoma (translocation-associated) 60.37(n)
    54.8(a)
      572173  NM_001126440.1  NP_001119912.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172496
    --
    25(a)
    1 ↔ 1
    3L(1645931-1647464)


    ENSEMBL Gene Tree for PRCC (if available)
    TreeFam Gene Tree for PRCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRCC (see all 798)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2015663621,2
    --156740870(+) CCCTC-/ATGGGG 1 -- int10--------
    rs112645441,2
    C,A,H--156740871(+) CCCTCA/TGGGGG 1 -- int11Minor allele frequency- T:0.00NA 2
    rs112645451,2
    C,A,H--156740872(+) CCTCTT/GGGGGG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs742293021,2
    C--156741476(+) AAATGG/TTTTTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1115597331,2
    C--156745456(+) CGCCAT/CCACCC 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs346671251,2
    C--156746256(+) TTTAT-/AGAGGTT 1 -- int10--------
    rs2001950711,2
    C--156748600(+) TTTTT-/TAGATG 1 -- int10--------
    rs1116230411,2
    C--156749327(+) CCAGCTAA/-TTTTT 1 -- cds11Minor allele frequency- -:0.00CSA 2
    rs38311291,2
    C,F--156752232(-) CTCAAA/-TATCT 1 -- int13Minor allele frequency- -:0.33NA CSA 6
    rs1126963641,2
    F--156753428(+) AGCTAT/CTCGGG 1 -- int11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for PRCC (156720402 - 156770609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PRCC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831659CNV Loss17160897
    nsv831648CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRCC
    DNA2.0 Custom Variant and Variant Library Synthesis for PRCC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179755    OMIM disorders: --

    UniProtKB/Swiss-Prot: PRCC_HUMAN, Q92733
  • Note=A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma.
    Translocation t(X;1)(p11.2;q21.2) with TFE3

  • 20 diseases for PRCC:    
    About MalaCards
    papillary renal cell carcinoma    renal cell carcinoma, papillary, 1    papillary renal carcinoma    papillary adenoma
    xanthogranulomatous pyelonephritis    renal cell carcinoma    oxyphilic adenoma    pyelonephritis
    alveolar soft part sarcoma    renal oncocytoma    adenoma    sarcoma
    tonsillitis    multiple myeloma    thyroiditis    myeloma
    cerebritis    malaria    prostatitis    endotheliitis

    5 diseases from the University of Copenhagen DISEASES database for PRCC:
    Renal cell carcinoma     Oxyphilic adenoma     Renal oncocytoma     Papillary adenoma
    Alveolar soft part sarcoma

    PRCC for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for PRCC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 63.2 4 11717438 (1), 11435707 (1), 8986805 (1), 12837690 (1)


    Export disorders for PRCC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRCC gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PRCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. (PubMed id 8872474)1, 2, 3, 9 Sidhar S.K.... Cooper C.S. (Hum. Mol. Genet. 1996)
    2. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. (PubMed id 8986805)1, 2, 9 Weterman M.A.J.... Geurts van Kessel A. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. (PubMed id 11717438)1, 2, 9 Weterman M.A.... van Kessel A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma. (PubMed id 11435707)1, 9 Weterman M.A....Geurts van Kessel A. (Cytogenet. Cell Genet. 2001)
    8. Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins. (PubMed id 10644981)1, 9 Weterman M.J....van Kessel A.G. (Oncogene 2000)
    9. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5546 HGNC: 9343 AceView: PRCC Ensembl:ENSG00000143294 euGenes: HUgn5546
    ECgene: PRCC Kegg: 5546 H-InvDB: PRCC

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRCC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRCC Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=PRCC[genesymbol]

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRCC gene:
    Search GeneIP for patents involving PRCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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