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Aliases for PRCC Gene

Aliases for PRCC Gene

  • Papillary Renal Cell Carcinoma (Translocation-Associated) 2 3
  • Papillary Renal Cell Carcinoma Translocation-Associated Gene Protein 3 4
  • RCCP1 3 6
  • TPRC 3 4
  • Proline-Rich Protein PRCC 3

External Ids for PRCC Gene

Previous GeneCards Identifiers for PRCC Gene

  • GC01P154606
  • GC01P152502
  • GC01P153515
  • GC01P153954
  • GC01P153550
  • GC01P155003
  • GC01P128095

Summaries for PRCC Gene

Entrez Gene Summary for PRCC Gene

  • This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

GeneCards Summary for PRCC Gene

PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated)) is a Protein Coding gene. Diseases associated with PRCC include renal cell carcinoma, papillary and translocation renal cell carcinoma. Among its related pathways are Transcriptional misregulation in cancer.

UniProtKB/Swiss-Prot for PRCC Gene

  • May regulate cell cycle progression through interaction with MAD2L2.

Gene Wiki entry for PRCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRCC Gene

Genomics for PRCC Gene

Regulatory Elements for PRCC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRCC Gene

Start:
156,750,610 bp from pter
End:
156,800,817 bp from pter
Size:
50,208 bases
Orientation:
Plus strand

Genomic View for PRCC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRCC Gene

Proteins for PRCC Gene

  • Protein details for PRCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92733-PRCC_HUMAN
    Recommended name:
    Proline-rich protein PRCC
    Protein Accession:
    Q92733
    Secondary Accessions:
    • A8K1F7
    • O00665
    • O00724
    • Q5SZ06

    Protein attributes for PRCC Gene

    Size:
    491 amino acids
    Molecular mass:
    52418 Da
    Quaternary structure:
    • Interacts with MAD2L2; the interaction is direct.

neXtProt entry for PRCC Gene

Proteomics data for PRCC Gene at MOPED

Post-translational modifications for PRCC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRCC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRCC Gene

Domains for PRCC Gene

Protein Domains for PRCC Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRCC: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PRCC Gene

Function for PRCC Gene

Molecular function for PRCC Gene

UniProtKB/Swiss-Prot Function: May regulate cell cycle progression through interaction with MAD2L2.

Gene Ontology (GO) - Molecular Function for PRCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11717438
genes like me logo Genes that share ontologies with PRCC: view

Animal Model Products

CRISPR Products

miRNA for PRCC Gene

miRTarBase miRNAs that target PRCC

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRCC Gene

Localization for PRCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRCC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRCC Gene COMPARTMENTS Subcellular localization image for PRCC gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11717438
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with PRCC: view

Pathways for PRCC Gene

genes like me logo Genes that share pathways with PRCC: view

Pathways by source for PRCC Gene

1 KEGG pathway for PRCC Gene

Gene Ontology (GO) - Biological Process for PRCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007093 mitotic cell cycle checkpoint IDA 11717438
genes like me logo Genes that share ontologies with PRCC: view

Transcripts for PRCC Gene

Unigene Clusters for PRCC Gene

Papillary renal cell carcinoma (translocation-associated):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRCC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRCC Gene

No ASD Table

Relevant External Links for PRCC Gene

GeneLoc Exon Structure for
PRCC
ECgene alternative splicing isoforms for
PRCC

Expression for PRCC Gene

mRNA expression in normal human tissues for PRCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRCC Gene

SOURCE GeneReport for Unigene cluster for PRCC Gene Hs.516948

mRNA Expression by UniProt/SwissProt for PRCC Gene

Q92733-PRCC_HUMAN
Tissue specificity: Ubiquitous in fetal and adult tissues
genes like me logo Genes that share expressions with PRCC: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRCC Gene

Orthologs for PRCC Gene

This gene was present in the common ancestor of animals.

Orthologs for PRCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRCC 35
  • 99.73 (n)
  • 100 (a)
PRCC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRCC 35
  • 93.75 (n)
  • 97.15 (a)
PRCC 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRCC 35
  • 91.89 (n)
  • 95.71 (a)
PRCC 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prcc 35
  • 89.23 (n)
  • 93.25 (a)
Prcc 16
Prcc 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRCC 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prcc 35
  • 90.25 (n)
  • 93.46 (a)
chicken
(Gallus gallus)
Aves PRCC 35
  • 74.41 (n)
  • 78.75 (a)
PRCC 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRCC 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10563 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prcc 35
  • 68.85 (n)
  • 69.23 (a)
zebrafish
(Danio rerio)
Actinopterygii prcc 35
  • 60.37 (n)
  • 54.8 (a)
prcc 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17249 36
  • 25 (a)
OneToOne
Species with no ortholog for PRCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRCC Gene

ENSEMBL:
Gene Tree for PRCC (if available)
TreeFam:
Gene Tree for PRCC (if available)

Paralogs for PRCC Gene

No data available for Paralogs for PRCC Gene

Variants for PRCC Gene

Sequence variations from dbSNP and Humsavar for PRCC Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4735 -- 156,797,289(+) TGAGC(A/C)GCCAA reference, missense
rs928392 -- 156,801,024(-) AGATT(A/G)GCAAT downstream-variant-500B
rs1044319 -- 156,800,544(+) CTGCT(C/T)TAAGC utr-variant-3-prime
rs1044348 -- 156,800,692(+) GGGCT(C/T)TGAGT utr-variant-3-prime
rs1044362 -- 156,800,753(+) TCCCC(A/C)CCACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PRCC Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897
nsv831659 CNV Loss 17160897

Relevant External Links for PRCC Gene

HapMap Linkage Disequilibrium report
PRCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRCC Gene

Disorders for PRCC Gene

(1) OMIM Diseases for PRCC Gene (179755)

UniProtKB/Swiss-Prot

PRCC_HUMAN
  • Note=A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.

(1) Novoseek inferred disease relationships for PRCC Gene

Disease -log(P) Hits PubMed IDs
carcinoma renal cell 63.2 4
genes like me logo Genes that share disorders with PRCC: view

Publications for PRCC Gene

  1. The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene. (PMID: 8872474) Sidhar S.K. … Cooper C.S. (Hum. Mol. Genet. 1996) 2 3 4 23
  2. Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas. (PMID: 8986805) Weterman M.A.J. … Geurts van Kessel A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  3. Impairment of MAD2B-PRCC interaction in mitotic checkpoint defective t(X;1)-positive renal cell carcinomas. (PMID: 11717438) Weterman M.A. … van Kessel A.G. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  4. Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins. (PMID: 10644981) Weterman M.J. … van Kessel A.G. (Oncogene 2000) 3 23
  5. Genomic structure, chromosomal localization, and embryonic expression of the mouse homolog of PRCC, a gene associated with papillary renal cell carcinoma. (PMID: 11435707) Weterman M.A. … Geurts van Kessel A. (Cytogenet. Cell Genet. 2001) 3 23

Products for PRCC Gene

Sources for PRCC Gene

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