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RNASEL Gene

protein-coding   GIFtS: 60

GC01M180809
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
(Previous name: prostate cancer 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RNS4, PRCA1)
Services    

Aliases &
Descriptions
for RNASEL

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp781D08126 2
EC 3.1.26.- 3
HPC1 5
MGC104972 2
MGC133329 2
OTTHUMP00000033148 2
PRCA1 2, 5
RNS4 2, 3, 5
Descriptions
2',5'-oligoisoadenylate synthetase-dependent 2
2-5A-dependent RNase 3
RNase L 3
Ribonuclease 4 2, 3
Ribonuclease L 2, 3
interferon-induced 2-5A-dependent RNase 2
prostate cancer 1 1
ribonuclease L (2',5'-oligoisoadenylate
synthetase-dependent) 2
External Ids
HGNC: 100501
Entrez Gene: 60412
UniProtKB: Q058233
Ensembl: ENSG000001358287
Search outside databases for aliases for RNASEL gene

Previous GC identifers: GC01M180070 GC01M177972 GC01M179063 GC01M179782 GC01M179274

Summaries
for RNASEL

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for RNASEL:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the
antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated
with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate
cancer 1 (HPC1) allele. [provided by RefSeq]

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Function: Endoribonuclease, mediator of interferon action, which play a role in mediating
resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA
turnover

Gene Wiki entry for RNASEL

Genomic Location
for RNASEL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RNASEL gene  

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RNASEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M180809:     (about GC identifiers)

Start:
 180,809,395 bp from pter
End:
 180,825,001 bp from pter
Size:
 15,607 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  

Proteins
for RNASEL

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823 (See protein sequence)
Recommended Name: 2-5A-dependent ribonuclease  
Size: 741 amino acids; 83533 Da
Cofactor: Manganese or magnesium. Required for optimal RNA cleavage rates
Subunit: Monomer (inactive form) or homodimer
Subcellular location: Cytoplasm. Mitochondrion
PDB structures from and Proteopedia :
1WDY (3D)    

REFSEQ proteins: NP_066956.1  

ENSEMBL proteins: 
ENSP00000356530 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (RNase L)
Human Recombinant Proteins from Abnova (RNASEL)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
GO:0005737 cytoplasm IEA--
GO:0005739 mitochondrion IEA--
About this table

Antibodies for RNASEL: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of RNASEL
Sigma-Aldrich Antibody Arrays and Antibodies for RNASEL
Browse R&D Systems for Antibodies
Antibodies from Abcam (RNase L), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (RNASEL)
Novus Biologicals Antibodies for RNASEL

Assays for RNASEL: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for RNASEL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5 InterPro domains/families:
 IPR017441 Protein_kinase_ATP_BS
 IPR000719 Prot_kinase_core
 IPR010513 RNase_L
 IPR006567 PUG-dom
 IPR002110 ANK


   GeneDecks  RNASEL for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q05823

ProtoNet protein and cluster: Q05823

2 Blocks protein families:
IPB006567 PUG
IPB010513 Ribonuclease 2-5A


UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Domain: The protein kinase domain is predicted to be catalytically inactive. It allows the
homodimerization
Domain: The nine ankyrin repeats also called 2-5A sensor constitute the 2-5A binding domain
Similarity: Belongs to the protein kinase superfamily
Similarity: Contains 9 ANK repeats
Similarity: Contains 1 KEN domain
Similarity: Contains 1 protein kinase domain

Gene Function
for RNASEL

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (RNASEL)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RNASEL)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021133

              Applied Biosystems Silencer® siRNAs for RNASEL

              Sigma-Aldrich siRNA and siRNA Panels for RNASEL  
                     Sigma-Aldrich shRNA Panels and shRNA for RNASEL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021133
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021133
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021133 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_021133

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Function: Endoribonuclease, mediator of interferon action, which play a role in mediating
resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA
turnover
Catalytic activity: Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of
discrete products ranging from between 4 and 22 nucleotides in length
Enzyme regulation: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the
homodimerization and subsequent activation occurs. Inhibited by RNase L inhibitor
Induction: By interferons
Enzyme Number (IUBMB): EC 3.1.26.- 

Genatlas biochemistry entry for RNASEL:
ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnasel):

hematopoietic systemimmune system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003723 RNA binding IDA7514601
GO:0004672 protein kinase activity IEA--
GO:0005524 ATP binding IEA--
GO:0008270 zinc ion binding IEA--
About this table

Pathways & Interactions
for RNASEL

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


2 Sigma-Aldrich "Your Favorite Gene" Pathways for  RNASEL  (Your Favorite Gene powered by Ingenuity) 
 Role of PKR in Interferon Induction and Antiviral Response
 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

   GeneDecks  RNASEL for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  RNASEL 


5/10 Interacting proteins for RNASEL (ENSP000003565303) via UniProtKB, MINT, and/or STRING (see all 10 )
InteractantInteraction Details
GeneCardExternal ID(s)
ABCE1ENSP000002965773STRING (score=.979)
STX1AENSP000002228123STRING (score=.939)
ELAC2ENSP000003374453STRING (score=.896)
RNASEH2AENSP000002214863STRING (score=.808)
ARENSP000003638223STRING (score=.77)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006397 mRNA processing IEA--
GO:0006468 protein amino acid phosphorylation NAS7514601
About this table

Drugs & Compounds
for RNASEL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RNASEL
10/14 Novoseek chemical compound relationships for RNASEL gene (see all 14 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ecyd 85.99 42 18668243 (3), 18029773 (2), 12903334 (2), 17150838 (2) (see all 5)
8-methyladenosine 83.89 2 12757397 (1)
oligoribonucleotide 62.32 5 8617774 (2), 14604670 (1), 10726660 (1), 10474231 (1)
phosphorothioate 46.28 5 7685081 (2), 7890727 (2), 14583476 (1)
rrna 43.86 19 8017832 (2), 11152576 (2), 12903195 (2), 12903334 (2) (see all 7)
oligonucleotide 41.81 10 7679499 (2), 18950583 (1), 11878909 (1), 9111293 (1) (see all 8)
atp 34.61 9 15013441 (1), 9862963 (1), 15383904 (1), 18160405 (1) (see all 7)
ifn-alpha 29.70 11 17431428 (3), 11585831 (2)
uridine 23.28 1 8223579 (1)
ribonucleic acid 1.14 4 12752687 (1), 16000857 (1)
About this table


Transcripts
for RNASEL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (RNASEL)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (RNASEL)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021133

              Sigma-Aldrich siRNA and siRNA Panels for RNASEL  
                     Sigma-Aldrich shRNA Panels and shRNA for RNASEL  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_021133  

REFSEQ mRNAs for RNASEL gene: 

NM_021133.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_021133  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021133
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021133
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021133 

Additional cDNA sequence: 

AK315231.1 BC090934.1 BC114433.1 BC115697.1 CR627369.1 DQ352452.1 

4 DOTS entries:

DT.211589  DT.86837487  DT.92002335  DT.425435 

24/57 AceView cDNA sequences (see all 57 ):

BX280477 CR627369 BQ216121 NM_021133 C01514 AW016315 AA046353 BX502854 
BQ030219 BP336508 BQ003187 CF527913 BG427155 BE049527 AA902343 AA257976 
AA377605 AW968304 BP335764 CF143886 BI259008 AI669749 BE778138 CA447181 

highest scoring ESTs for RNASEL:

AI669749 AW501465 BU940316 BX502854 CF143886 AA046353 AA257976 AA258106 AA377605 AA779940 

Unigene Cluster for RNASEL:

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Hs.518545  [show with all ESTs]
Unigene Representative Sequence: BC090934


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000367559  

Expression
for RNASEL

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RNASEL expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for RNASEL

1 / 2 / 3

5 probe-sets matching RNASEL gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
46123_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI669749 0.80 1.00 0.91 1

221287_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021133 0.60 1.00 0.82 1

229285_at2, 3 U133-B 1 1.00 1.00 -- -- AI669749 0.80 1.00 0.91 1

221287_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

229285_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  RNASEL for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AATCATTGTG

SOURCE GeneReport for Unigene cluster: Hs.518545

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus,
small intestine, colon and peripheral blood leukocytes

Orthologs
for RNASEL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for RNASEL gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 RNASEL1   -- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 80.45(n)
71.51(a)		 490310  XM_547430.2  XP_547430.2 
chimpanzee
(Pan troglodytes)		 RNASEL1   -- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 98.74(n)
97.3(a)		 469607  XM_524990.2  XP_524990.2 
rat
(Rattus norvegicus)		 Rnasel1   -- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 73.11(n)
63.7(a)		 359726  NM_182673.1  NP_872614.1 
mouse
(Mus musculus)		 Rnasel1, 5 15
 ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)1, 5 73.24(n)1
64.93(a)1		 240141  NM_011882.11  NP_036012.11 
 AF2810455  AI5935195  (see all 15)
chicken
(Gallus gallus)		 RNASEL1   -- ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 55(n)
43.99(a)		 424410  NM_001031267.1  NP_001026438.1 
About this table        Species with no ortholog for RNASEL

ENSEMBL Gene Tree for RNASEL

Paralogs
for RNASEL

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for RNASEL

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/27 NCBI SNPs in RNASEL are shown (see all 27 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 53)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs121352471,2
A,C,F,H180810560(+) ATGCAT/CCcagt 1 -- ut31 ese34Minor allele frequency- C:0.20EU EA WA 412
--
rs110721,2
A,C,F,H180809954(-) ATGTTT/CAATAA 1 -- ut31 ese314Minor allele frequency- C:0.21MN EU EA WA NA CSAM 1312
rs5894021,2
A,C,H180808934(+) CACCAT/AGTGAG 1 -- ng514Minor allele frequency- A:0.00MN EU EA 482
rs10482601,2
A,C,F180809474(-) TGGTTC/GTCTGA 1 -- ut31 ese34Minor allele frequency- G:0.08MN NA 324
--
rs6200701,2
A,C,O180822953(-) AAAATA/GTATAG 1 -- ng310--------
--
rs109111001,2
C,F180823326(+) AAATTG/ACTTTC 1 -- ng313Minor allele frequency- A:0.27NA 140
--
rs6429171,2
C,F180809798(+) aaataA/Gggata 1 -- ut31 ese39Minor allele frequency- G:0.02MN NA CSAM EA 706
--
rs6412651,2
A,C180809449(+) GACATA/GTCCAG 1 -- ut31 ese31Minor allele frequency- G:0.00MN 184
--
rs10482541,2
F180810289(-) ACCTGA/CCTTAA 1 -- ut31 ese31Minor allele frequency- C:0.28MN 184
rs6186851,2
C180823223(-) CTATCA/GAAAGA 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for RNASEL (up to first 250kb)

Disorders & Mutations
for RNASEL

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 180435   disorders: 601518  

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

  • Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1
    (HPC1) [MIM:176807, 601518]

    • 10/26 Novoseek disease relationships for RNASEL gene (see all 26 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer, hereditary, 1 94.00 11 12590567 (1), 11799394 (1), 15604285 (1), 16241858 (1) (see all 8)
    chronic fatigue syndrome 69.85 16 7893988 (2), 8148461 (2), 15924878 (2), 16277015 (2) (see all 11)
    prostate cancer 64.96 112 12590567 (6), 16537704 (6), 18189233 (5), 18767027 (4) (see all 43)
    virus infection 57.16 20 18029773 (2), 7679499 (2), 1374726 (1), 16235172 (1) (see all 13)
    parainfluenza 44.66 2 9858317 (1), 17535916 (1)
    fibrosarcoma 35.49 2 17055253 (2)
    vesicular stomatitis 31.24 1 9858317 (1)
    malignant glioma 24.98 1 11586885 (1)
    immunodeficiency 19.34 7 9847332 (2), 7890727 (1), 18160405 (1)
    herpes simplex 19.05 3 19042034 (1), 17205688 (1)
    About this table

    Human Gene Mutation Database: RNASEL
    Genetic Association Database: RNASEL
    Human Genome Epidemiology Navigator: RNASEL (31 documents)

    Medical News
    for RNASEL

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for RNASEL

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/229 PubMed articles for RNASEL gene (see all 229 ):

    Search for RNASEL

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNASEL

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6041 HGNC: 10050 AceView: RNASEL Ensembl:ENSG00000135828 euGenes: HUgn6041
    ECgene: RNASEL H-InvDB: RNASEL

    Other Databases showing RNASEL

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing RNASEL

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RNASEL Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for RNASEL

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for RNASEL

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RNASEL:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for RNASEL-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for RNASEL Antibodies for RNASEL
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for RNASEL Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (RNase L)
     Antibodies (RNase L)
     Search OriGene for RNASEL
     Search Tocris compounds for RNASEL




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RNASEL

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