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PRC1 Gene

protein-coding   GIFtS: 59
GCID: GC15M091509

Protein Regulator Of Cytokinesis 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Regulator Of Cytokinesis 11 2
Anaphase Spindle Elongation 1 Homolog (S. Cerevisiae)1
ASE12
Anaphase Spindle Elongation 1 Homolog2
Protein Regulating Cytokinesis 12

External Ids:    HGNC: 93411   Entrez Gene: 90552   Ensembl: ENSG000001989017   OMIM: 6034845   UniProtKB: O436633   

Export aliases for PRC1 gene to outside databases

Previous GC identifers: GC15M087698 GC15M084949 GC15M089096 GC15M089239 GC15M089310 GC15M067620


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRC1 Gene:
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S
and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase.
It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic
manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a
substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and
concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jun 2012)

GeneCards Summary for PRC1 Gene:
PRC1 (protein regulator of cytokinesis 1) is a protein-coding gene. Diseases associated with PRC1 include atypical lipomatous tumor, and liposarcoma. GO annotations related to this gene include microtubule binding and identical protein binding.

UniProtKB/Swiss-Prot: PRC1_HUMAN, O43663
Function: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35
nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required
for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates
PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle

Gene Wiki entry for PRC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRC1 gene promoter:
         E2F-4   E2F-3a   PPAR-alpha   E2F-5   E2F   E2F-1   Lmo2   E2F-2   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRC1 promoter sequence
   Search Chromatin IP Primers for PRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

PRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRC1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M091509:  view genomic region     (about GC identifiers)

Start:
91,509,268 bp from pter      End:
91,538,859 bp from pter
Size:
29,592 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PRC1_HUMAN, O43663 (See protein sequence)
Recommended Name: Protein regulator of cytokinesis 1  
Size: 620 amino acids; 71607 Da
Subunit: Homodimer. Interacts with the C-terminal Rho-GAP domain and the basic region of RACGAP1. The interaction
with RACGAP1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal
spindle morphology. Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23
during late mitosis. Interacts with KIF14 and KIF20A. Interacts with PLK1
4 PDB 3D structures from and Proteopedia for PRC1:
3NRX (3D)        3NRY (3D)        4L3I (3D)        4L6Y (3D)    
Secondary accessions: A6NC44 B4DLR1 Q9BSB6
Alternative splicing: 3 isoforms:  O43663-1   O43663-2   O43663-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PRC1: NX_O43663

Explore proteomics data for PRC1 at MOPED

Post-translational modifications: 

  • Phosphorylation by CDK1 in early mitosis holds PRC1 in an inactive monomeric state, during the metaphase to
    anaphase transition, PRC1 is dephosphorylated, promoting interaction with KIF4A, which then translocates PRC1
    along mitotic spindles to the plus ends of antiparallel interdigitating microtubules. Dephosphorylation also
    promotes MT-bundling activity by allowing dimerization. Phosphorylation by CDK1 prevents PLK1-binding: upon
    degradation of CDK1 at anaphase and dephosphorylation, it is then phosphorylated by PLK1, leading to cytokinesis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001254509.1  NP_003972.1  NP_955445.1  

    ENSEMBL proteins: 
     ENSP00000377793   ENSP00000456737   ENSP00000354679   ENSP00000451344   ENSP00000453977  
     ENSP00000409549   ENSP00000453063   ENSP00000453455   ENSP00000453117   ENSP00000354618  

    PRC1 Human Recombinant Protein Products:

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    Novus Biologicals PRC1 Protein
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    Sino Biological Recombinant Protein for PRC1
    Sino Biological Cell Lysate for PRC1
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    Cloud-Clone Corp. Proteins for PRC1

    PRC1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PRC1
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    PRC1 Assay Products:

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    Cloud-Clone Corp. CLIAs for PRC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007145 MAP65_Ase1_PRC1

    Graphical View of Domain Structure for InterPro Entry O43663

    ProtoNet protein and cluster: O43663

    UniProtKB/Swiss-Prot: PRC1_HUMAN, O43663
    Domain: Microtubule binding occurs via a basic patch in the central spectrin-like domain and requires also the
    unstructured C-terminal domain
    Similarity: Belongs to the MAP65/ASE1 family


    PRC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRC1_HUMAN, O43663
    Function: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35
    nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required
    for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates
    PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14744859
    GO:0008017microtubule binding IEA--
    GO:0019901protein kinase binding IPI17351640
    GO:0042802identical protein binding IPI--
         
    PRC1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for PRC1:
     Increased 8N DNA content  Increased cell number in G2M,   Increased cilium length after   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PRC1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PRC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PRC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PRC1:
    hsa-mir-92a-3p (MIRT049644), hsa-mir-505-3p (MIRT040993), hsa-mir-125a-5p (MIRT045708), hsa-mir-548b-3p (MIRT016238), hsa-mir-373-3p (MIRT002532), hsa-mir-1260b (MIRT052746)

    Block miRNA regulation of human, mouse, rat PRC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PRC1 (see all 22):
    hsa-miR-124* hsa-miR-3685 hsa-miR-520f hsa-miR-146a hsa-miR-1245 hsa-miR-1271 hsa-miR-512-3p hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmidPRC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRC1

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    GenScript: all cDNA clones in your preferred vector (see all 3): PRC1 (NM_003981)
    Sino Biological Human cDNA Clone for PRC1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRC1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRC1_HUMAN, O43663: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly localized to
    the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes
    with the cell midbody during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005819spindle IDA17351640

    PRC1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PRC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Roles of Polo Like Kinases
    Mitotic Roles of Polo Like Kinases
    2Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PRC1
        Mitotic Roles of Polo Like Kinases

    1 Cell Signaling Technology (CST) Pathway for PRC1
        Cytoskeletal Signaling




    PRC1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PRC1: 
              p53 Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PRC1 (O436631, 2, 3 ENSP000003777934) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-68167 I2D: score=5 STRING: ENSP00000311695
    DAXXQ9UER73I2D: score=2 
    ENSG00000206206Q9UER73I2D: score=2 
    ENSG00000206279Q9UER73I2D: score=2 
    ENSG00000227046Q9UER73I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000022mitotic spindle elongation TAS9885575
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000910cytokinesis IDA17351640

    PRC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PRC1 gene (4 alternative transcripts): 
    NM_001267580.1  NM_003981.3  NM_199413.2  NM_199414.1  

    Unigene Cluster for PRC1:

    Protein regulator of cytokinesis 1
    Hs.366401  [show with all ESTs]
    Unigene Representative Sequence: NM_003981
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000394249(uc002bqm.3) ENST00000556972 ENST00000361188(uc002bqn.3)
    ENST00000555455 ENST00000560423 ENST00000442656 ENST00000559828 ENST00000559326
    ENST00000560914 ENST00000556982 ENST00000553494 ENST00000557763 ENST00000417173(uc010uqt.1)
    ENST00000560605 ENST00000557905 ENST00000555791 ENST00000555745 ENST00000559811

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PRC1 (see all 22):
    hsa-miR-124* hsa-miR-3685 hsa-miR-520f hsa-miR-146a hsa-miR-1245 hsa-miR-1271 hsa-miR-512-3p hsa-miR-633
    SwitchGear 3'UTR luciferase reporter plasmidPRC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PRC1
    Clone
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    OriGene clones in human, mouse for PRC1 (see all 16)
    OriGene ORF clones in mouse, rat for PRC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): PRC1 (NM_003981)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PRC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRC1
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      QuantiTect SYBR Green Assays in human, mouse, rat PRC1
      QuantiFast Probe-based Assays in human, mouse, rat PRC1

    Additional mRNA sequence: 

    AF044588.1 AK297117.1 AK312600.1 BC003138.1 BC005140.2 BX647317.1 

    24 DOTS entries:

    DT.99981927  DT.92445563  DT.40199655  DT.100797160  DT.100044701  DT.317539  DT.121031296  DT.121031284 
    DT.121031343  DT.100797164  DT.95368804  DT.100678990  DT.100797168  DT.121031256  DT.65286405  DT.100044699 
    DT.121031391  DT.97760053  DT.102839905  DT.121031282  DT.121031297  DT.92445569  DT.95368789  DT.95303290 

    Selected AceView cDNA sequences (see all 379):

    BQ771706 AI699813 BE560082 BG575829 BP374698 BE208066 BU196607 AA910989 
    BP364070 BM551262 BM006444 BQ014832 BU839171 BU145882 BI026821 BU178274 
    BX102974 NM_003981 BE464668 BU193198 AA454518 BU174570 AI288872 CA426361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRC1 (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
    SP1:                                            -                             -     -                                   -     -     -                           
    SP2:                                            -                             -     -                                   -     -     -                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                          -     -                           

    ExUns: 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c
    SP1:                                                                                                                                          
    SP2:                                      -     -                                                     -                                       
    SP3:                                                                                            -     -                                       
    SP4:                                                                                                        -     -     -                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PRC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACTACTGG
    PRC1 Expression
    About this image


    PRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Metanephros
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
             Testis Cord
     
     Gonad
             Secondary Oocyte Antral Follicle
    PRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.366401
        Pathway & Disease-focused RT2 Profiler PCR Array including PRC1: 
              p53 Signaling Pathway in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PRC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Prc11 , 5 protein regulator of cytokinesis 11, 5 85.31(n)1
    83.66(a)1
      7 (45.62 cM)5
    2334061  NM_145150.31  NP_660132.21 
     802944505 
    chicken
    (Gallus gallus)
    Aves PRC11 protein regulator of cytokinesis 1 64.49(n)
    63.08(a)
      770336  NM_001079753.1  NP_001073221.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    48(a)
    42(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343759.1(17614-34179)
    3(103813069-103813852)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC055974.12   -- 76.11(n)    BC055974.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC046886.12   -- 74.9(n)   393203  BC046886.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16553   -- 26(a)   9F5   --


    ENSEMBL Gene Tree for PRC1 (if available)
    TreeFam Gene Tree for PRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRC1 (see all 156)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754809011,2
    F--91532360(+) ATAATA/G/TAAAAA 3 -- int11NA 2
    rs2002865701,2
    --91532360(+) ATAAT-/AAAAAA 3 -- int10--------
    rs1386009011,2
    C--91532411(+) TAGAAC/TCCTCA 3 -- int10--------
    rs1848467221,2
    --91532503(+) GAGACA/GGGGCC 3 -- int10--------
    rs71794281,2
    C,F,A--91532565(+) ctcaaC/Agccct 3 -- int19Minor allele frequency- A:0.44NA WA CSA EA 370
    rs64967451,2
    C,F,A--91532630(+) gccatC/Tgtgct 3 -- int110Minor allele frequency- T:0.44NA WA CSA EA 372
    rs781285611,2
    C--91532772(+) CACCCA/GGCCCC 3 -- int10--------
    rs1473387381,2
    C--91532815(+) TTTATC/TACTGG 3 -- int10--------
    rs64967461,2
    C,F,A--91532869(+) cacaaA/Ctgttt 3 -- int110Minor allele frequency- C:0.46NA WA CSA EA 371
    rs1393270821,2
    --91532876(+) GTTTAC/TAGCAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for PRC1 (91509268 - 91538859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PRC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1247904CNV Deletion17803354
    esv1007089CNV Insertion20482838
    esv1307442CNV Insertion17803354
    nsv515661CNV Loss19592680
    nsv833090CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603484    OMIM disorders: --

    9 diseases for PRC1:    
    About MalaCards
    atypical lipomatous tumor    liposarcoma    sinusitis    choroiditis
    pancreatic cancer    hypertension    pancreatitis    cerebritis
    breast cancer


    PRC1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PRC1
    Human Genome Epidemiology (HuGE) Navigator: PRC1 (7 documents)

    Export disorders for PRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRC1 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with PRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. (PubMed id 9885575)1, 2, 3, 9 Jiang W....Fukunaga R. (Mol. Cell 1998)
    2. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. (PubMed id 15625105)1, 2, 9 Zhu C. and Jiang W. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    3. Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. (PubMed id 14744859)1, 2, 9 Ban R.... Tanaka H. (J. Biol. Chem. 2004)
    4. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    5. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. (PubMed id 20691902)1, 2 Subramanian R.... Kapoor T.M. (Cell 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. A genome-wide association study of hypertension and blood pressure in African Americans. (PubMed id 19609347)1, 4 Adeyemo A....Rotimi C. (PLoS Genet. 2009)
    8. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PubMed id 19468300)1, 2 Wolfe B.A.... Glotzer M. (PLoS Biol. 2009)
    9. Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. (PubMed id 17351640)1, 2 Neef R....Barr F.A. (Nat. Cell Biol. 2007)
    10. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PubMed id 15297875)1, 2 Kurasawa Y.... Todokoro K. (EMBO J. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9055 HGNC: 9341 AceView: PRC1 Ensembl:ENSG00000198901 euGenes: HUgn9055
    ECgene: PRC1 H-InvDB: PRC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRC1 gene:
    Search GeneIP for patents involving PRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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