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Aliases for PRC1 Gene

Aliases for PRC1 Gene

  • Protein Regulator Of Cytokinesis 1 2 3 5
  • Anaphase Spindle Elongation 1 Homolog (S. Cerevisiae) 2
  • Anaphase Spindle Elongation 1 Homolog 3
  • Protein Regulating Cytokinesis 1 3
  • ASE1 3

External Ids for PRC1 Gene

Previous GeneCards Identifiers for PRC1 Gene

  • GC15M087698
  • GC15M084949
  • GC15M089096
  • GC15M089239
  • GC15M089310
  • GC15M091509
  • GC15M067620

Summaries for PRC1 Gene

Entrez Gene Summary for PRC1 Gene

  • This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

GeneCards Summary for PRC1 Gene

PRC1 (Protein Regulator Of Cytokinesis 1) is a Protein Coding gene. Among its related pathways are Semaphorin interactions and Cytoskeletal Signaling. GO annotations related to this gene include identical protein binding and microtubule binding.

UniProtKB/Swiss-Prot for PRC1 Gene

  • Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Gene Wiki entry for PRC1 Gene

Additional gene information for PRC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRC1 Gene

Genomics for PRC1 Gene

Regulatory Elements for PRC1 Gene

Enhancers for PRC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H090949 1 ENCODE dbSUPER 10.7 +45.8 45847 1 PKNOX1 ATF1 BACH1 FOSL1 ZNF316 POLR2A GATA2 NFE2 MAFK CREM UNC45A PRC1 MAN2A2 RCCD1 GC15P090938
GH15H090991 1.4 Ensembl ENCODE 0.7 +2.0 1955 4 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS DEK RCCD1 VPS33B ENSG00000259314 UNC45A VPS33B-DT ENSG00000259212 FES PRC1 GC15M090978 ENSG00000200142
GH15H090988 0.8 Ensembl ENCODE 0.4 +7.0 7028 0 HDGF PKNOX1 GATA3 IKZF1 HMBOX1 IKZF2 RCCD1 VPS33B-DT VPS33B PRC1 ENSG00000200142 GC15M090978
GH15H090981 0.7 ENCODE 0.4 +13.6 13564 0 PKNOX1 ZNF687 TRIM22 CEBPB ELF1 CEBPG DPF2 BATF MLLT1 IKZF2 RCCD1 VPS33B ENSG00000200142 GC15M090978 PRC1
GH15H090986 0.6 ENCODE 0.4 +8.6 8624 0 ZNF362 ZSCAN5C NBN CREB1 ATF7 MLLT1 DPF2 VPS33B-DT VPS33B ENSG00000224441 HDDC3 UNC45A ENSG00000200142 PRC1 GC15M090978
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRC1 on UCSC Golden Path with GeneCards custom track

Promoters for PRC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000081158 1429 2801 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for PRC1 Gene

Chromosome:
15
Start:
90,966,038 bp from pter
End:
90,995,629 bp from pter
Size:
29,592 bases
Orientation:
Minus strand

Genomic View for PRC1 Gene

Genes around PRC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRC1 Gene

Proteins for PRC1 Gene

  • Protein details for PRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43663-PRC1_HUMAN
    Recommended name:
    Protein regulator of cytokinesis 1
    Protein Accession:
    O43663
    Secondary Accessions:
    • A6NC44
    • B4DLR1
    • H9KV59
    • Q9BSB6

    Protein attributes for PRC1 Gene

    Size:
    620 amino acids
    Molecular mass:
    71607 Da
    Quaternary structure:
    • Homodimer (PubMed:20691902). Interacts with the C-terminal Rho-GAP domain and the basic region of RACGAP1 (PubMed:14744859). The interaction with RACGAP1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology (PubMed:14744859). Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis (PubMed:15297875, PubMed:16431929). Interacts with KIF14 and KIF20A (PubMed:15625105, PubMed:16431929). Interacts with PLK1 (PubMed:19468300). Interacts with KIF20B (PubMed:17409436).

    Three dimensional structures from OCA and Proteopedia for PRC1 Gene

    Alternative splice isoforms for PRC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRC1 Gene

Post-translational modifications for PRC1 Gene

  • Phosphorylation by CDK1 in early mitosis holds PRC1 in an inactive monomeric state, during the metaphase to anaphase transition, PRC1 is dephosphorylated, promoting interaction with KIF4A, which then translocates PRC1 along mitotic spindles to the plus ends of antiparallel interdigitating microtubules. Dephosphorylation also promotes MT-bundling activity by allowing dimerization. Phosphorylation by CDK1 prevents PLK1-binding: upon degradation of CDK1 at anaphase and dephosphorylation, it is then phosphorylated by PLK1, leading to cytokinesis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRC1 (PRC1)

No data available for DME Specific Peptides for PRC1 Gene

Domains & Families for PRC1 Gene

Gene Families for PRC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PRC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43663

UniProtKB/Swiss-Prot:

PRC1_HUMAN :
  • Microtubule binding occurs via a basic patch in the central spectrin-like domain and requires also the unstructured C-terminal domain.
  • Belongs to the MAP65/ASE1 family.
Domain:
  • Microtubule binding occurs via a basic patch in the central spectrin-like domain and requires also the unstructured C-terminal domain.
Family:
  • Belongs to the MAP65/ASE1 family.
genes like me logo Genes that share domains with PRC1: view

Function for PRC1 Gene

Molecular function for PRC1 Gene

UniProtKB/Swiss-Prot Function:
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

Phenotypes From GWAS Catalog for PRC1 Gene

Gene Ontology (GO) - Molecular Function for PRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14744859
GO:0008017 microtubule binding IEA --
GO:0019894 kinesin binding IPI 16431929
GO:0019901 protein kinase binding IPI 17351640
genes like me logo Genes that share ontologies with PRC1: view
genes like me logo Genes that share phenotypes with PRC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRC1
  • Applied Biological Materials Clones for PRC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRC1 Gene

Localization for PRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRC1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. {ECO:0000269 PubMed:17409436}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRC1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (3)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus TAS,IDA 17409436
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IDA 17351640
genes like me logo Genes that share ontologies with PRC1: view

Pathways & Interactions for PRC1 Gene

genes like me logo Genes that share pathways with PRC1: view

Pathways by source for PRC1 Gene

1 Cell Signaling Technology pathway for PRC1 Gene
1 Qiagen pathway for PRC1 Gene

Gene Ontology (GO) - Biological Process for PRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000022 mitotic spindle elongation TAS 9885575
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000910 cytokinesis IDA,IEA 17351640
GO:0001578 microtubule bundle formation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PRC1: view

No data available for SIGNOR curated interactions for PRC1 Gene

Drugs & Compounds for PRC1 Gene

No Compound Related Data Available

Transcripts for PRC1 Gene

Unigene Clusters for PRC1 Gene

Protein regulator of cytokinesis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRC1
  • Applied Biological Materials Clones for PRC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PRC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5: - -
SP6:
SP7:
SP8: - - - -
SP9: - - - - - - - - -
SP10:
SP11: - -
SP12: - - - -
SP13: - -
SP14:
SP15: - - -
SP16:
SP17: - - - - -
SP18:
SP19: - - - - - - -

ExUns: 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ^ 20a · 20b · 20c
SP1:
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - - -
SP19:

Relevant External Links for PRC1 Gene

GeneLoc Exon Structure for
PRC1
ECgene alternative splicing isoforms for
PRC1

Expression for PRC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRC1 Gene

This gene is overexpressed in Testis (x4.5).

Protein differential expression in normal tissues from HIPED for PRC1 Gene

This gene is overexpressed in Breast (36.8) and Pancreas (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRC1 Gene



Protein tissue co-expression partners for PRC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRC1 Gene:

PRC1

SOURCE GeneReport for Unigene cluster for PRC1 Gene:

Hs.366401

mRNA Expression by UniProt/SwissProt for PRC1 Gene:

O43663-PRC1_HUMAN
Tissue specificity: Overexpressed in bladder cancer cells (PubMed:17409436).

Evidence on tissue expression from TISSUES for PRC1 Gene

  • Liver(3.6)
  • Nervous system(2.5)
  • Kidney(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with PRC1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PRC1 Gene

Orthologs for PRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRC1 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia PRC1 34 33
  • 90.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRC1 33 34
  • 90.22 (n)
mouse
(Mus musculus)
Mammalia Prc1 16 34 33
  • 85.31 (n)
rat
(Rattus norvegicus)
Mammalia Prc1 33
  • 84.87 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves PRC1 34 33
  • 64.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia prc1 33
  • 64.73 (n)
zebrafish
(Danio rerio)
Actinopterygii prc1b 33 34
  • 63.61 (n)
prc1a 34
  • 51 (a)
OneToMany
PRC1 (1 of 3) 34
  • 41 (a)
OneToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CG1655 35
  • 26 (a)
feo 34
  • 21 (a)
OneToMany
sofe 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8500 34
  • 40 (a)
OneToOne
Species where no ortholog for PRC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRC1 Gene

ENSEMBL:
Gene Tree for PRC1 (if available)
TreeFam:
Gene Tree for PRC1 (if available)

Paralogs for PRC1 Gene

No data available for Paralogs for PRC1 Gene

Variants for PRC1 Gene

Sequence variations from dbSNP and Humsavar for PRC1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs112187198 Uncertain significance 90,966,789(+) GGGCA(C/T)AGTCA intron-variant, utr-variant-3-prime
rs112770009 Uncertain significance 90,966,398(+) AACTG(C/T)GGGGG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs11855081 Uncertain significance 90,982,184(+) ACTTT(C/T)CCCCC intron-variant
rs11857612 Uncertain significance 90,982,088(+) ACTAA(C/T)AAGTA intron-variant, nc-transcript-variant
rs12898311 Uncertain significance 90,974,550(+) TCTTC(C/G)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRC1 Gene

Variant ID Type Subtype PubMed ID
esv1007089 CNV insertion 20482838
esv1247904 CNV deletion 17803354
esv1307442 CNV insertion 17803354
nsv515661 CNV loss 19592680
nsv833090 CNV loss 17160897

Variation tolerance for PRC1 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRC1 Gene

Disorders for PRC1 Gene

Relevant External Links for PRC1

Genetic Association Database (GAD)
PRC1
Human Genome Epidemiology (HuGE) Navigator
PRC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRC1

No disorders were found for PRC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRC1 Gene

Publications for PRC1 Gene

  1. PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis. (PMID: 9885575) Jiang W … Fukunaga R (Molecular cell 1998) 2 3 4 22 60
  2. KIF14 and citron kinase act together to promote efficient cytokinesis. (PMID: 16431929) Gruneberg U … Barr FA (The Journal of cell biology 2006) 3 4 22 60
  3. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. (PMID: 15625105) Zhu C … Jiang W (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 60
  4. Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. (PMID: 14744859) Ban R … Tanaka H (The Journal of biological chemistry 2004) 3 4 22 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for PRC1 Gene

  • Addgene plasmids for PRC1

Sources for PRC1 Gene

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