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Aliases for PRB3 Gene

Aliases for PRB3 Gene

  • Proline Rich Protein BstNI Subfamily 3 2 3 5
  • Parotid Salivary Glycoprotein G1 3 4
  • Proline-Rich Protein G1 3 4
  • BstNI Type Basic Salivary Proline-Rich Protein 3 3
  • Basic Salivary Proline-Rich Protein 3 3
  • G1 Parotid Salivary Glycoprotein 3
  • PRG 3
  • G1 3

External Ids for PRB3 Gene

Previous GeneCards Identifiers for PRB3 Gene

  • GC12U990078
  • GC12M011564
  • GC12M011320
  • GC12M011311
  • GC12M011312
  • GC12M011315
  • GC12M011316
  • GC12M011418
  • GC12M011184

Summaries for PRB3 Gene

Entrez Gene Summary for PRB3 Gene

  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Long" allele. The protein isoforms encoded by this gene are recognized as the "first line of oral defense" against the detrimental effects of polyphenols in the diet and pathogen infections. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Nov 2015]

GeneCards Summary for PRB3 Gene

PRB3 (Proline Rich Protein BstNI Subfamily 3) is a Protein Coding gene. An important paralog of this gene is PRB2.

UniProtKB/Swiss-Prot for PRB3 Gene

  • Acts as a receptor for the Gram-negative bacterium F.nucleatum.

Gene Wiki entry for PRB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRB3 Gene

Genomics for PRB3 Gene

Regulatory Elements for PRB3 Gene

Enhancers for PRB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G011307 0.3 FANTOM5 64.8 -37.9 -37932 0.1 PRB1 PRB4 PRB3 PRB2 PRH1 PRH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRB3 Gene

Chromosome:
12
Start:
11,265,914 bp from pter
End:
11,269,805 bp from pter
Size:
3,892 bases
Orientation:
Minus strand

Genomic View for PRB3 Gene

Genes around PRB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRB3 Gene

Proteins for PRB3 Gene

  • Protein details for PRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04118-PRB3_HUMAN
    Recommended name:
    Basic salivary proline-rich protein 3
    Protein Accession:
    Q04118
    Secondary Accessions:
    • Q15188
    • Q4VAY3
    • Q4VAY4
    • Q7M4M9
    • Q9UCT9

    Protein attributes for PRB3 Gene

    Size:
    309 amino acids
    Molecular mass:
    30980 Da
    Quaternary structure:
    • The Gl-8 variant forms a disulfide-bonded heterodimer with salivary perodixase.
    SequenceCaution:
    • Sequence=CAA30477.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for PRB3 Gene

Post-translational modifications for PRB3 Gene

  • N- and O-glycosylated; contains about 50% carbohydrate. This is composed of highly fucosylated N-linked saccharides, the major structure is a biantennary asialosaccharide containing 2 fucose residues on one antenna and an unsubstituted terminal lactosamine sequence on the other. The Gram-negative bacterium F.nucleatum binds to carbohydrates containing unsubstituted GalBeta1,4GlcNAc residues.
  • Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin. Besides on the N-terminal of mature PRB3, pyroglutamate formation found on at least Gln-67, Gln-88, Gln-214 and Gln-295.
  • The Gl-8 variant contains an interchain disulfide bond with salivary peroxidase.
  • Glycosylation at posLast=6666, posLast=8787, Ser89, Asn108, Asn129, posLast=150150, posLast=171171, posLast=192192, posLast=213213, and Asn255
  • Modification sites at PhosphoSitePlus

Other Protein References for PRB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRB3 Gene

Domains & Families for PRB3 Gene

Gene Families for PRB3 Gene

Protein Domains for PRB3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRB3: view

No data available for UniProtKB/Swiss-Prot for PRB3 Gene

Function for PRB3 Gene

Molecular function for PRB3 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,basic,glycosylated,BstNI subfamily 3,including among others,the polymorphic variant concavalin A-binding protein
UniProtKB/Swiss-Prot Function:
Acts as a receptor for the Gram-negative bacterium F.nucleatum.
genes like me logo Genes that share phenotypes with PRB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRB3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRB3 Gene

Localization for PRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRB3 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for PRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 1894623
genes like me logo Genes that share ontologies with PRB3: view

No data available for Subcellular locations from COMPARTMENTS for PRB3 Gene

Pathways & Interactions for PRB3 Gene

No Data Available

Interacting Proteins for PRB3 Gene

Selected Interacting proteins: Q04118-PRB3_HUMAN for PRB3 Gene via IID

Gene Ontology (GO) - Biological Process for PRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0050829 defense response to Gram-negative bacterium NAS 1894623
genes like me logo Genes that share ontologies with PRB3: view

No data available for Pathways by source and SIGNOR curated interactions for PRB3 Gene

Drugs & Compounds for PRB3 Gene

No Compound Related Data Available

Transcripts for PRB3 Gene

mRNA/cDNA for PRB3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRB3 Gene

Proline-rich protein BstNI subfamily 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PRB3

Alternative Splicing Database (ASD) splice patterns (SP) for PRB3 Gene

No ASD Table

Relevant External Links for PRB3 Gene

GeneLoc Exon Structure for
PRB3
ECgene alternative splicing isoforms for
PRB3

Expression for PRB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRB3 Gene

mRNA differential expression in normal tissues according to GTEx for PRB3 Gene

This gene is overexpressed in Testis (x16.9), Skin - Sun Exposed (Lower leg) (x6.7), Skin - Not Sun Exposed (Suprapubic) (x5.5), and Bladder (x4.5).

Protein differential expression in normal tissues from HIPED for PRB3 Gene

This gene is overexpressed in Nasal epithelium (54.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRB3 Gene



Protein tissue co-expression partners for PRB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRB3 Gene:

PRB3

SOURCE GeneReport for Unigene cluster for PRB3 Gene:

Hs.73031
genes like me logo Genes that share expression patterns with PRB3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRB3 Gene

Orthologs for PRB3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRB3 34
  • 93.88 (n)
Species where no ortholog for PRB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRB3 Gene

ENSEMBL:
Gene Tree for PRB3 (if available)
TreeFam:
Gene Tree for PRB3 (if available)

Paralogs for PRB3 Gene

Paralogs for PRB3 Gene

genes like me logo Genes that share paralogs with PRB3: view

Variants for PRB3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRB3 Gene

PRB3_HUMAN-Q04118
The number of repeats is polymorphic and varies among different alleles. The sequence shown is that of allele L (long). There is an allele S (short) which contains 6 tandem repeats.

Sequence variations from dbSNP and Humsavar for PRB3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs71455367 Pathogenic 11,268,104(+) GGTAC(A/C/G)TTGGG reference, missense
rs1000676497 -- 11,271,223(+) CAGAC(C/T)TCTTG upstream-variant-2KB
rs1001192013 -- 11,271,423(+) GAATA(C/T)ATTAT upstream-variant-2KB
rs1001340491 -- 11,268,122(+) TCCTC(C/T)TTGTG reference, missense
rs1001922342 -- 11,269,945(+) GAACT(A/G)TGTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRB3 Gene

Variant ID Type Subtype PubMed ID
dgv175e201 CNV deletion 23290073
esv1018672 CNV deletion 17803354
esv1318358 CNV deletion 17803354
esv2586387 CNV deletion 19546169
esv2745557 CNV deletion 23290073
esv2745559 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv994058 CNV deletion 20482838
nsv1038277 CNV loss 25217958
nsv1050050 CNV loss 25217958
nsv1143558 CNV deletion 24896259
nsv428272 CNV gain+loss 18775914
nsv975451 CNV duplication 23825009

Variation tolerance for PRB3 Gene

Gene Damage Index Score: 3.26; 52.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRB3 Gene

Human Gene Mutation Database (HGMD)
PRB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRB3

Disorders for PRB3 Gene

Relevant External Links for PRB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRB3

No disorders were found for PRB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRB3 Gene

Publications for PRB3 Gene

  1. Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein. (PMID: 1894623) Gillece-Castro B.L. … Fisher S.J. (J. Biol. Chem. 1991) 2 3 4 22 64
  2. Alleles at the PRB3 locus coding for a disulfide-bonded human salivary proline-rich glycoprotein (Gl 8) and a null in an Ashkenazi Jew. (PMID: 2171329) Azen E.A. … Kim H.-S. (Am. J. Hum. Genet. 1990) 3 4 22 64
  3. Finding new posttranslational modifications in salivary proline-rich proteins. (PMID: 20879038) Vitorino R. … Amado F.L. (Proteomics 2010) 3 4 64
  4. Identification of Lys-Pro-Gln as a novel cleavage site specificity of saliva-associated proteases. (PMID: 18463091) Helmerhorst E.J. … Oppenheim F.G. (J. Biol. Chem. 2008) 3 4 64
  5. PRB3 null mutations result in absence of the proline-rich glycoprotein Gl and abolish Fusobacterium nucleatum interactions with saliva in vitro. (PMID: 8406834) Azen E. … Fisher S.J. (Infect. Immun. 1993) 3 22 64

Products for PRB3 Gene

Sources for PRB3 Gene

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