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Aliases for PRB2 Gene

Aliases for PRB2 Gene

  • Proline Rich Protein BstNI Subfamily 2 2 3 5
  • Con1 Glycoprotein 3 4
  • Proline-Rich Protein BstNI, Subfamily-2 (Parotid Size Variant) 3
  • Basic Salivary Proline-Rich Protein 2 3
  • Salivary Proline-Rich Protein 2 3
  • Basic Proline-Rich Peptide P-E 3
  • Salivary Proline-Rich Protein 4
  • PRPPRB1 3
  • IB-9 3
  • CP7 3
  • Ps 3

External Ids for PRB2 Gene

Previous GeneCards Identifiers for PRB2 Gene

  • GC12M011274
  • GC12U900037
  • GC12M011435
  • GC12M011437
  • GC12M011314
  • GC12M011402
  • GC12M011544
  • GC12M011308

Summaries for PRB2 Gene

Entrez Gene Summary for PRB2 Gene

  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRB2 Gene

PRB2 (Proline Rich Protein BstNI Subfamily 2) is a Protein Coding gene. Among its related pathways are Salivary secretion. An important paralog of this gene is PRB3.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRB2 Gene

Genomics for PRB2 Gene

Regulatory Elements for PRB2 Gene

Enhancers for PRB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G011307 0.3 FANTOM5 64.6 +193.3 193305 0.1 PRB1 PRB4 PRB3 PRB2 PRH1 PRH2
GH12G011500 1 ENCODE 0.7 +0.3 280 0.2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 SP5 IQSEC3P2 PRB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRB2 Gene

Chromosome:
12
Start:
11,391,540 bp from pter
End:
11,501,041 bp from pter
Size:
109,502 bases
Orientation:
Minus strand

Genomic View for PRB2 Gene

Genes around PRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRB2 Gene

Proteins for PRB2 Gene

  • Protein details for PRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02812-PRB2_HUMAN
    Recommended name:
    Basic salivary proline-rich protein 2
    Protein Accession:
    P02812
    Secondary Accessions:
    • O00599
    • P02811
    • P04281

    Protein attributes for PRB2 Gene

    Size:
    416 amino acids
    Molecular mass:
    40799 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Peptides IB-9 and P-E are the same peptide.

neXtProt entry for PRB2 Gene

Post-translational modifications for PRB2 Gene

  • N- and O-glycosylated. In head and neck cancer patients, O-glycosylated with glucosylgalactosyl carbohydrate moiety. This modification would require prior hydroxylation on the lysine residue.
  • Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin.
  • Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Pyroglutamate formation found on at least Gln-398 and Gln-400.
  • Glycosylation at posLast=168168, posLast=230230, posLast=232232, and Asn272
  • Modification sites at PhosphoSitePlus

Other Protein References for PRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRB2 Gene

Domains & Families for PRB2 Gene

Gene Families for PRB2 Gene

Protein Domains for PRB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRB2: view

No data available for UniProtKB/Swiss-Prot for PRB2 Gene

Function for PRB2 Gene

Molecular function for PRB2 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,basic,glycosylated,BstNI subfamily 2,including among others,the polymorphic variant concavalin A-binding protein in exon 3 of PRB2L (CON 1+)

Gene Ontology (GO) - Molecular Function for PRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with PRB2: view

Phenotypes for PRB2 Gene

genes like me logo Genes that share phenotypes with PRB2: view

Animal Model Products

CRISPR Products

miRNA for PRB2 Gene

miRTarBase miRNAs that target PRB2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRB2 Gene

Localization for PRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRB2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRB2: view

Pathways & Interactions for PRB2 Gene

SuperPathway Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with PRB2: view

Pathways by source for PRB2 Gene

1 KEGG pathway for PRB2 Gene

Interacting Proteins for PRB2 Gene

Gene Ontology (GO) - Biological Process for PRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with PRB2: view

No data available for SIGNOR curated interactions for PRB2 Gene

Drugs & Compounds for PRB2 Gene

No Compound Related Data Available

Transcripts for PRB2 Gene

mRNA/cDNA for PRB2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRB2 Gene

Proline-rich protein BstNI subfamily 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRB2 Gene

No ASD Table

Relevant External Links for PRB2 Gene

GeneLoc Exon Structure for
PRB2
ECgene alternative splicing isoforms for
PRB2

Expression for PRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRB2 Gene

mRNA differential expression in normal tissues according to GTEx for PRB2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2), Brain - Caudate (basal ganglia) (x7.8), Brain - Putamen (basal ganglia) (x7.2), Brain - Frontal Cortex (BA9) (x4.9), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for PRB2 Gene

This gene is overexpressed in Saliva (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRB2 Gene



Protein tissue co-expression partners for PRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PRB2 Gene:

PRB2

SOURCE GeneReport for Unigene cluster for PRB2 Gene:

Hs.654486

Evidence on tissue expression from TISSUES for PRB2 Gene

  • Saliva(4.3)
genes like me logo Genes that share expression patterns with PRB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRB2 Gene

Orthologs for PRB2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 94 (a)
ManyToMany
-- 35
  • 84 (a)
ManyToMany
Species where no ortholog for PRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRB2 Gene

ENSEMBL:
Gene Tree for PRB2 (if available)
TreeFam:
Gene Tree for PRB2 (if available)

Paralogs for PRB2 Gene

Paralogs for PRB2 Gene

(1) SIMAP similar genes for PRB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRB2: view

Variants for PRB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRB2 Gene

PRB2_HUMAN-P02812
The number of repeats is polymorphic and varies among different alleles (PubMed:2851479).

Sequence variations from dbSNP and Humsavar for PRB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000050133 -- 11,396,670(+) AGCTC(A/T)TTATG upstream-variant-2KB
rs1000144511 -- 11,396,843(+) CTGCA(C/T)TGTTA upstream-variant-2KB
rs1002392883 -- 11,395,687(+) GTCAG(A/G)TGTTT upstream-variant-2KB
rs1002486068 -- 11,395,959(+) AGATG(A/G)TCAAT upstream-variant-2KB
rs1004046205 -- 11,394,713(+) GTTAT(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRB2 Gene

Variant ID Type Subtype PubMed ID
dgv1379n100 CNV loss 25217958
dgv1380n100 CNV loss 25217958
dgv1382n100 CNV gain 25217958
dgv1383n100 CNV loss 25217958
dgv1388n100 CNV gain+loss 25217958
dgv1389n100 CNV gain 25217958
dgv1390n100 CNV loss 25217958
dgv175e201 CNV deletion 23290073
dgv184n27 CNV loss 19166990
dgv2373n54 CNV loss 21841781
dgv2374n54 CNV gain 21841781
dgv2376n54 CNV gain+loss 21841781
dgv2377n54 CNV loss 21841781
dgv2378n54 CNV gain+loss 21841781
dgv2379n54 CNV loss 21841781
dgv23e203 CNV gain+loss 21179565
dgv272n67 CNV loss 20364138
dgv35n17 CNV loss 16327808
dgv461e212 CNV loss 25503493
dgv67n111 CNV duplication 26073780
esv2421844 OTHER complex 20811451
esv25911 CNV loss 19812545
esv2670133 CNV deletion 23128226
esv2745561 CNV deletion 23290073
esv2759879 CNV loss 17122850
esv33471 CNV gain+loss 17666407
esv3580146 CNV loss 25503493
esv3580148 CNV loss 25503493
esv3581027 CNV gain 25503493
esv3581038 CNV gain 25503493
esv3628574 CNV loss 21293372
esv3892140 CNV gain 25118596
esv3892141 CNV loss 25118596
nsv1037113 CNV gain 25217958
nsv1159980 OTHER complex 26073780
nsv428272 CNV gain+loss 18775914
nsv437140 CNV loss 16327808
nsv482165 CNV gain 20164927
nsv516262 CNV gain+loss 19592680
nsv557550 CNV loss 21841781
nsv557570 CNV gain 21841781
nsv608 CNV deletion 18451855
nsv818887 CNV gain 17921354
nsv818890 CNV gain+loss 17921354
nsv818891 CNV gain 17921354
nsv818892 CNV loss 17921354
nsv821059 CNV duplication 20802225
nsv826251 CNV gain 20364138
nsv8921 CNV gain+loss 18304495
nsv976576 CNV duplication 23825009

Variation tolerance for PRB2 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRB2

Disorders for PRB2 Gene

Relevant External Links for PRB2

Genetic Association Database (GAD)
PRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRB2

No disorders were found for PRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRB2 Gene

Publications for PRB2 Gene

  1. PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. (PMID: 8554050) Azen E.A. … Niece R.L. (Am. J. Hum. Genet. 1996) 2 3 4 64
  2. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. (PMID: 22142827) Innocenti F. … Ratain M.J. (Clin. Cancer Res. 2012) 3 46 64
  3. Basic proline-rich proteins from human parotid saliva: relationships of the covalent structures of ten proteins from a single individual. (PMID: 1849422) Kauffman D.L. … Keller P.J. (Biochemistry 1991) 3 4 64
  4. Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. (PMID: 2851479) Lyons K.M. … Smithies O. (Genetics 1988) 3 4 64
  5. Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. (PMID: 2993301) Maeda N. … Smithies O. (J. Biol. Chem. 1985) 3 4 64

Products for PRB2 Gene

Sources for PRB2 Gene

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