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Aliases for PRB2 Gene

Aliases for PRB2 Gene

  • Proline-Rich Protein BstNI Subfamily 2 2 3 5
  • Con1 Glycoprotein 3 4
  • Proline-Rich Protein BstNI, Subfamily-2 (Parotid Size Variant) 3
  • Salivary Proline-Rich Protein 2 3
  • Basic Proline-Rich Peptide P-E 3
  • Salivary Proline-Rich Protein 4
  • PRPPRB1 3
  • IB-9 3
  • CP7 3
  • Ps 3

External Ids for PRB2 Gene

Previous GeneCards Identifiers for PRB2 Gene

  • GC12M011274
  • GC12U900037
  • GC12M011435
  • GC12M011437
  • GC12M011314
  • GC12M011402
  • GC12M011544
  • GC12M011308

Summaries for PRB2 Gene

Entrez Gene Summary for PRB2 Gene

  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRB2 Gene

PRB2 (Proline-Rich Protein BstNI Subfamily 2) is a Protein Coding gene. Diseases associated with PRB2 include Diffuse Gastric Cancer. Among its related pathways are Salivary secretion. An important paralog of this gene is PRB1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRB2 Gene

Genomics for PRB2 Gene

Regulatory Elements for PRB2 Gene

Enhancers for PRB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRB2 on UCSC Golden Path with GeneCards custom track

Promoters for PRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRB2 Gene

11,391,540 bp from pter
11,501,041 bp from pter
109,502 bases
Minus strand

Genomic View for PRB2 Gene

Genes around PRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRB2 Gene

Proteins for PRB2 Gene

  • Protein details for PRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Basic salivary proline-rich protein 2
    Protein Accession:
    Secondary Accessions:
    • O00599
    • P02811
    • P04281

    Protein attributes for PRB2 Gene

    416 amino acids
    Molecular mass:
    40799 Da
    Quaternary structure:
    No Data Available
    • Peptides IB-9 and P-E are the same peptide.

neXtProt entry for PRB2 Gene

Proteomics data for PRB2 Gene at MOPED

Post-translational modifications for PRB2 Gene

  • N- and O-glycosylated. In head and neck cancer patients, O-glycosylated with glucosylgalactosyl carbohydrate moiety. This modification would require prior hydroxylation on the lysine residue.
  • Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin.
  • Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Pyroglutamate formation found on at least Gln-398 and Gln-400.
  • Glycosylation at Asn 168, Asn 230, Ser 232, and Asn 272
  • Modification sites at PhosphoSitePlus

Other Protein References for PRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRB2 Gene

Domains & Families for PRB2 Gene

Gene Families for PRB2 Gene

Protein Domains for PRB2 Gene


Suggested Antigen Peptide Sequences for PRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRB2: view

No data available for UniProtKB/Swiss-Prot for PRB2 Gene

Function for PRB2 Gene

Molecular function for PRB2 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,basic,glycosylated,BstNI subfamily 2,including among others,the polymorphic variant concavalin A-binding protein in exon 3 of PRB2L (CON 1+)

Phenotypes for PRB2 Gene

GenomeRNAi human phenotypes for PRB2:
genes like me logo Genes that share phenotypes with PRB2: view

Animal Model Products

CRISPR Products

miRNA for PRB2 Gene

miRTarBase miRNAs that target PRB2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRB2 Gene

Localization for PRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRB2 Gene


Subcellular locations from

Jensen Localization Image for PRB2 Gene COMPARTMENTS Subcellular localization image for PRB2 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PRB2: view

Pathways & Interactions for PRB2 Gene

SuperPathways for PRB2 Gene

Superpath Contained pathways
1 Salivary secretion
genes like me logo Genes that share pathways with PRB2: view

Pathways by source for PRB2 Gene

1 KEGG pathway for PRB2 Gene

Interacting Proteins for PRB2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000374013 for PRB2 Gene via STRING

Gene Ontology (GO) - Biological Process for PRB2 Gene


No data available for SIGNOR curated interactions for PRB2 Gene

Drugs & Compounds for PRB2 Gene

No Compound Related Data Available

Transcripts for PRB2 Gene

mRNA/cDNA for PRB2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRB2 Gene

Proline-rich protein BstNI subfamily 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRB2 Gene

No ASD Table

Relevant External Links for PRB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRB2 Gene

mRNA expression in normal human tissues for PRB2 Gene

mRNA differential expression in normal tissues according to GTEx for PRB2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2), Brain - Caudate (basal ganglia) (x7.8), Brain - Putamen (basal ganglia) (x7.2), Brain - Frontal Cortex (BA9) (x4.9), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for PRB2 Gene

This gene is overexpressed in Saliva (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRB2 Gene

SOURCE GeneReport for Unigene cluster for PRB2 Gene Hs.654486

genes like me logo Genes that share expression patterns with PRB2: view

Protein tissue co-expression partners for PRB2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRB2 Gene

Orthologs for PRB2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
-- 36
  • 84 (a)
Species with no ortholog for PRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRB2 Gene

Gene Tree for PRB2 (if available)
Gene Tree for PRB2 (if available)

Paralogs for PRB2 Gene

Paralogs for PRB2 Gene

(1) SIMAP similar genes for PRB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PRB2: view

Variants for PRB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRB2 Gene

The number of repeats is polymorphic and varies among different alleles (PubMed:2851479).

Sequence variations from dbSNP and Humsavar for PRB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10845349 - 11,393,258(+) TTGAG(A/G)TTTGT reference, missense
rs34305575 - 11,393,380(+) CACTT(C/T)GGGAC reference, missense
rs1921331 -- 11,393,874(+) CCTTG(A/G)GGCTG reference, synonymous-codon
rs7297470 -- 11,394,053(+) ATTTT(C/T)ATCAG intron-variant
rs16931354 -- 11,395,448(+) ATCTT(C/T)TCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRB2 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
dgv477e1 CNV Complex 17122850
dgv478e1 CNV Complex 17122850
dgv194e201 CNV Deletion 23290073
nsv516262 CNV Gain+Loss 19592680
dgv1375n71 CNV Gain 21882294
dgv1376n71 CNV Gain 21882294
dgv184n27 CNV Loss 19166990
nsv608 CNV Loss 18451855
dgv1377n71 CNV Gain 21882294
nsv826251 CNV Gain 20364138
nsv8921 CNV Gain+Loss 18304495
dgv35n17 CNV Loss 16327808
nsv821059 CNV Duplication 20802225
esv25911 CNV Loss 19812545
dgv272n67 CNV Loss 20364138
esv2421844 OTHER Complex 20811451
esv2745561 CNV Deletion 23290073
esv33471 CNV Gain+Loss 17666407
essv24169 CNV CNV 17122850
esv2670133 CNV Deletion 23128226
nsv818887 CNV Gain 17921354
nsv818890 CNV Gain+Loss 17921354
nsv437140 CNV Loss 16327808
nsv818891 CNV Gain 17921354
nsv482165 CNV Gain 20164927
nsv818892 CNV Loss 17921354

Variation tolerance for PRB2 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.32; 70.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for PRB2 Gene

Disorders for PRB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PRB2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
diffuse gastric cancer
  • signet ring cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PRB2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRB2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRB2 Gene

Publications for PRB2 Gene

  1. PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. (PMID: 8554050) Azen E.A. … Niece R.L. (Am. J. Hum. Genet. 1996) 2 3 4 67
  2. The intriguing heterogeneity of human salivary proline-rich proteins: Short title: Salivary proline-rich protein species. (PMID: 26375204) Manconi B. … Messana I. (J Proteomics 2016) 3
  3. pRb2/p130 is Delocalized in Cytoplasm in Diffuse Gastric Cancer: A Preliminary Study. (PMID: 25205458) Cito L. … Giordano A. (J. Cell. Physiol. 2014) 3
  4. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3
  5. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. (PMID: 22142827) Innocenti F. … Ratain M.J. (Clin. Cancer Res. 2012) 3

Products for PRB2 Gene

Sources for PRB2 Gene