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Aliases for PRB1 Gene

Aliases for PRB1 Gene

  • Proline-Rich Protein BstNI Subfamily 1 2 3 5
  • BstNI Type Basic Salivary Proline-Rich Protein 1 3
  • Salivary Proline-Rich Protein 4
  • Parotid Middle Band Protein 3
  • Salivary Protein Pe 3
  • PRB1L 3
  • PRB1M 3
  • PMF 3
  • PMS 3
  • PM 3

External Ids for PRB1 Gene

Previous GeneCards Identifiers for PRB1 Gene

  • GC12P011051
  • GC12M011648
  • GC12M011405
  • GC12M011398
  • GC12M011399
  • GC12M011401
  • GC12M011504
  • GC12M011269

Summaries for PRB1 Gene

Entrez Gene Summary for PRB1 Gene

  • This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Medium" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

GeneCards Summary for PRB1 Gene

PRB1 (Proline-Rich Protein BstNI Subfamily 1) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and Salivary secretion. An important paralog of this gene is PRB4.

Gene Wiki entry for PRB1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRB1 Gene

Genomics for PRB1 Gene

Regulatory Elements for PRB1 Gene

Genomic Location for PRB1 Gene

Chromosome:
12
Start:
11,351,823 bp from pter
End:
11,395,566 bp from pter
Size:
43,744 bases
Orientation:
Minus strand

Genomic View for PRB1 Gene

Genes around PRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRB1 Gene

Proteins for PRB1 Gene

  • Protein details for PRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04280-PRP1_HUMAN
    Recommended name:
    Basic salivary proline-rich protein 1
    Protein Accession:
    P04280
    Secondary Accessions:
    • Q08805
    • Q15186
    • Q15187
    • Q15214
    • Q15215
    • Q16038

    Protein attributes for PRB1 Gene

    Size:
    392 amino acids
    Molecular mass:
    38546 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRB1 Gene

Proteomics data for PRB1 Gene at MOPED

Post-translational modifications for PRB1 Gene

  • O-glycosylated.
  • Proteolytically cleaved at the tripeptide Xaa-Pro-Gln, where Xaa in the P(3) position is mostly lysine. The endoprotease may be of microbial origin.
  • Pyroglutamate formation occurs on terminal Gln residues of cleaved peptides. Besides on the N-terminal of mature PBR1, pyroglutamate formation found on at least Gln-58.
  • Glycosylation at Ser 40, Ser 87, Ser 150, and Ser 330
  • Modification sites at PhosphoSitePlus

Other Protein References for PRB1 Gene

No data available for DME Specific Peptides for PRB1 Gene

Domains & Families for PRB1 Gene

Gene Families for PRB1 Gene

Protein Domains for PRB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PRB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PRB1: view

No data available for UniProtKB/Swiss-Prot for PRB1 Gene

Function for PRB1 Gene

Molecular function for PRB1 Gene

GENATLAS Biochemistry:
salivary proline-rich protein,basic,glycosylated,BstNI subfamily 1,including among others,the polymorphic variant concavalin-A binding protein in exon 3 of PRB1M (CON 2+)

Phenotypes for PRB1 Gene

GenomeRNAi human phenotypes for PRB1:
genes like me logo Genes that share phenotypes with PRB1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRB1 Gene

Localization for PRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRB1 Gene COMPARTMENTS Subcellular localization image for PRB1 gene
Compartment Confidence
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for PRB1 Gene

Pathways & Interactions for PRB1 Gene

genes like me logo Genes that share pathways with PRB1: view

Pathways by source for PRB1 Gene

1 BioSystems pathway for PRB1 Gene
1 KEGG pathway for PRB1 Gene

Interacting Proteins for PRB1 Gene

Gene Ontology (GO) - Biological Process for PRB1 Gene

None

No data available for SIGNOR curated interactions for PRB1 Gene

Drugs & Compounds for PRB1 Gene

(1) Additional Compounds for PRB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRB1: view

Transcripts for PRB1 Gene

Unigene Clusters for PRB1 Gene

Proline-rich protein BstNI subfamily 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRB1 Gene

No ASD Table

Relevant External Links for PRB1 Gene

GeneLoc Exon Structure for
PRB1
ECgene alternative splicing isoforms for
PRB1

Expression for PRB1 Gene

mRNA expression in normal human tissues for PRB1 Gene

mRNA differential expression in normal tissues according to GTEx for PRB1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x10.5), Brain - Caudate (basal ganglia) (x9.2), Brain - Putamen (basal ganglia) (x7.6), Brain - Nucleus accumbens (basal ganglia) (x6.3), and Skin - Not Sun Exposed (Suprapubic) (x5.6).

Protein differential expression in normal tissues from HIPED for PRB1 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRB1 Gene



SOURCE GeneReport for Unigene cluster for PRB1 Gene Hs.631726

genes like me logo Genes that share expression patterns with PRB1: view

Protein tissue co-expression partners for PRB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRB1 Gene

Orthologs for PRB1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for PRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 94 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
Species with no ortholog for PRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRB1 Gene

ENSEMBL:
Gene Tree for PRB1 (if available)
TreeFam:
Gene Tree for PRB1 (if available)

Paralogs for PRB1 Gene

Paralogs for PRB1 Gene

(1) SIMAP similar genes for PRB1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PRB1: view

Variants for PRB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PRB1 Gene

P04280-PRP1_HUMAN
The number of repeats is polymorphic and varies among different alleles. The sequence shown is that of allele L (long). There are allele M (medium) and allele S (short) which contain 12 and 9 approximate tandem repeats repectively.

Sequence variations from dbSNP and Humsavar for PRB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs762588 -- 11,356,169(-) GCCCT(A/C/G)TCCTG upstream-variant-2KB
rs762589 -- 11,356,156(-) CAGGC(C/T)GCGGG upstream-variant-2KB
rs762590 -- 11,355,899(-) AGTCT(G/T)ACCTA upstream-variant-2KB
rs1882252 -- 11,355,472(+) ATCTT(C/T)TCCCT intron-variant
rs1882253 -- 11,355,477(+) TTCCC(C/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRB1 Gene

Variant ID Type Subtype PubMed ID
dgv475e1 CNV Complex 17122850
dgv476e1 CNV Complex 17122850
nsv428272 CNV Gain+Loss 18775914
dgv477e1 CNV Complex 17122850
dgv478e1 CNV Complex 17122850
dgv194e201 CNV Deletion 23290073
nsv509455 CNV Insertion 20534489
esv2745560 CNV Deletion 23290073
nsv516262 CNV Gain+Loss 19592680
dgv1375n71 CNV Gain 21882294
dgv1376n71 CNV Gain 21882294
dgv184n27 CNV Loss 19166990
nsv608 CNV Loss 18451855
nsv438190 CNV Loss 16468122
dgv1377n71 CNV Gain 21882294
nsv826251 CNV Gain 20364138
nsv8921 CNV Gain+Loss 18304495
dgv35n17 CNV Loss 16327808
nsv821059 CNV Duplication 20802225
nsv437137 CNV Loss 16327808
esv25911 CNV Loss 19812545
nsv482164 CNV Gain 20164927
nsv514648 CNV Loss 21397061
esv1483948 CNV Insertion 17803354
dgv272n67 CNV Loss 20364138
esv2421844 OTHER Complex 20811451

Variation tolerance for PRB1 Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRB1 Gene

HapMap Linkage Disequilibrium report
PRB1
Human Gene Mutation Database (HGMD)
PRB1

Disorders for PRB1 Gene

Relevant External Links for PRB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRB1

No disorders were found for PRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRB1 Gene

Publications for PRB1 Gene

  1. PRBI gene variants coding for length and null polymorphisms among human salivary Ps, PmF, PmS, and Pe proline-rich proteins (PRPs). (PMID: 8317492) Azen E.A. … Niece R.L. (Am. J. Hum. Genet. 1993) 2 3 4 23 67
  2. Encoding of human basic and glycosylated proline-rich proteins by the PRB gene complex and proteolytic processing of their precursor proteins. (PMID: 9796777) Stubbs M. … Bennick A. (Arch. Oral Biol. 1998) 3 23
  3. The structure and evolution of the human salivary proline-rich protein gene family. (PMID: 8422499) Kim H.-S. … Maeda N. (Mamm. Genome 1993) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for PRB1 Gene

Sources for PRB1 Gene

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