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Aliases for PRAMEF22 Gene

Aliases for PRAMEF22 Gene

  • PRAME Family Member 22 2 3
  • PRAMEF3L 3

External Ids for PRAMEF22 Gene

Previous GeneCards Identifiers for PRAMEF22 Gene

  • GC01P012957
  • GC01P012958
  • GC01P013035
  • GC01M013222

Summaries for PRAMEF22 Gene

GeneCards Summary for PRAMEF22 Gene

PRAMEF22 (PRAME Family Member 22) is a Protein Coding gene. GO annotations related to this gene include retinoic acid receptor binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF22 Gene

Genomics for PRAMEF22 Gene

Regulatory Elements for PRAMEF22 Gene

Enhancers for PRAMEF22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRAMEF22 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRAMEF22 Gene

13,005,048 bp from pter
13,005,624 bp from pter
577 bases
Plus strand

Genomic View for PRAMEF22 Gene

Genes around PRAMEF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF22 Gene

Proteins for PRAMEF22 Gene

  • Protein details for PRAMEF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRAME family member 22
    Protein Accession:
    Secondary Accessions:
    • A6NMM3

    Protein attributes for PRAMEF22 Gene

    481 amino acids
    Molecular mass:
    55489 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAMEF22 Gene

Proteomics data for PRAMEF22 Gene at MOPED

Post-translational modifications for PRAMEF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF22 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF22 Gene

Domains & Families for PRAMEF22 Gene

Gene Families for PRAMEF22 Gene

Protein Domains for PRAMEF22 Gene


Suggested Antigen Peptide Sequences for PRAMEF22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRAME family.
  • Contains 2 LRR (leucine-rich) repeats.
  • Belongs to the PRAME family.
  • Contains 2 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PRAMEF22: view

Function for PRAMEF22 Gene

Gene Ontology (GO) - Molecular Function for PRAMEF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042974 retinoic acid receptor binding IEA --
genes like me logo Genes that share ontologies with PRAMEF22: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAMEF22 Gene

Localization for PRAMEF22 Gene

Subcellular locations from

Jensen Localization Image for PRAMEF22 Gene COMPARTMENTS Subcellular localization image for PRAMEF22 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAMEF22 Gene

Pathways & Interactions for PRAMEF22 Gene

SuperPathways for PRAMEF22 Gene

No Data Available

Interacting Proteins for PRAMEF22 Gene

Gene Ontology (GO) - Biological Process for PRAMEF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PRAMEF22: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF22 Gene

Drugs & Compounds for PRAMEF22 Gene

No Compound Related Data Available

Transcripts for PRAMEF22 Gene

mRNA/cDNA for PRAMEF22 Gene

(1) REFSEQ mRNAs :

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF22 Gene

No ASD Table

Relevant External Links for PRAMEF22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRAMEF22 Gene

mRNA expression in normal human tissues for PRAMEF22 Gene

Protein differential expression in normal tissues from HIPED for PRAMEF22 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAMEF22 Gene

SOURCE GeneReport for Unigene cluster for PRAMEF22 Gene Hs.712522

genes like me logo Genes that share expression patterns with PRAMEF22: view

Protein tissue co-expression partners for PRAMEF22 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRAMEF22 Gene

Orthologs for PRAMEF22 Gene

No data available for Orthologs and Evolution for PRAMEF22 Gene

Paralogs for PRAMEF22 Gene

genes like me logo Genes that share paralogs with PRAMEF22: view

No data available for Paralogs for PRAMEF22 Gene

Variants for PRAMEF22 Gene

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF22 Gene

Variant ID Type Subtype PubMed ID
dgv20e1 CNV Complex 17122850
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
dgv22e1 CNV Complex 17122850
dgv24e1 CNV Complex 17122850
dgv147n71 CNV Gain 21882294
dgv149n71 CNV Gain 21882294
nsv517190 CNV Gain+Loss 19592680
esv28644 CNV Gain+Loss 19812545
nsv8768 CNV Gain+Loss 18304495
esv32750 CNV Gain 17666407
nsv2965 CNV Loss 18451855
nsv7172 OTHER Inversion 18451855
dgv162n71 CNV Loss 21882294
nsv820528 CNV Deletion 20802225
dgv17e201 CNV Deletion 23290073
nsv819147 CNV Gain 19587683
nsv821616 CNV Gain 15273396
esv2675529 CNV Deletion 23128226
nsv508902 CNV Insertion 20534489
nsv510936 CNV Complex 20534489
esv1004322 CNV Gain 20482838
dgv14e199 CNV Deletion 23128226
nsv433183 CNV Loss 18776910
nsv871634 CNV Gain 21882294
dgv168n71 CNV Gain 21882294
nsv870885 CNV Loss 21882294
esv1000242 CNV Gain 20482838
esv25471 CNV Gain+Loss 19812545
nsv832981 CNV Loss 17160897

Variation tolerance for PRAMEF22 Gene

Gene Damage Index Score: 3.18; 51.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for PRAMEF22 Gene

Disorders for PRAMEF22 Gene

Relevant External Links for PRAMEF22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRAMEF22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAMEF22 Gene

Publications for PRAMEF22 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Duplication and positive selection among hominin-specific PRAME genes. (PMID: 16159394) Birtle Z. … Ponting C. (BMC Genomics 2005) 3

Products for PRAMEF22 Gene

Sources for PRAMEF22 Gene