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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PRAMEF22 Gene

protein-coding   GIFtS: 31
GCID: GC01P013035

PRAME Family Member 22

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
PRAME Family Member 221 2
PRAMEF3L2

External Ids:    HGNC: 343931   Entrez Gene: 6536062   Ensembl: ENSG000002045087   UniProtKB: A3QJZ63   

Export aliases for PRAMEF22 gene to outside databases

Previous GC identifers: GC01P012957 GC01P012958


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PRAMEF22 Gene: 
PRAMEF22 (PRAME family member 22) is a protein-coding gene. Diseases associated with PRAMEF22 include melanoma. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF19.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_018912.2  NC_000001.10  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PRAMEF22 gene promoter:
         HOXA9B   p53   LCR-F1   Meis-1b   AREB6   PPAR-gamma1   PPAR-gamma2   TGIF   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PRAMEF22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAMEF22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

PRAMEF22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRAMEF22 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P013035:  view genomic region     (about GC identifiers)

Start:
13,035,543 bp from pter      End:
13,038,381 bp from pter
Size:
2,839 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRA22_HUMAN, A3QJZ6 (See protein sequence)
Recommended Name: PRAME family member 22  
Size: 481 amino acids; 55489 Da
Caution: It is uncertain whether Met-1 or Met-3 is the initiator
Secondary accessions: A6NMM3

Explore the universe of human proteins at neXtProt for PRAMEF22: NX_A3QJZ6

Explore proteomics data for PRAMEF22 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A3QJZ6

  • PRAMEF22 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PRAMEF22 Protein Expression
    REFSEQ proteins: NP_001094101.1  
    ENSEMBL proteins: 
     ENSP00000365358  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026292 PRAME/Leu_rich_rep-con_p14
     IPR026271 PRAME_family

    Graphical View of Domain Structure for InterPro Entry A3QJZ6

    ProtoNet protein and cluster: A3QJZ6

    UniProtKB/Swiss-Prot: PRA22_HUMAN, A3QJZ6
    Similarity: Belongs to the PRAME family
    Similarity: Contains 2 LRR (leucine-rich) repeats


    PRAMEF22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042974retinoic acid receptor binding IEA--
         
    PRAMEF22 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRAMEF22

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0043066negative regulation of apoptotic process IEA--
    GO:0045596negative regulation of cell differentiation IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IEA--
    GO:0048387negative regulation of retinoic acid receptor signaling pathway IEA--

    PRAMEF22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PRAMEF22 (PRA22)

    Search CenterWatch for drugs/clinical trials and news about PRAMEF22 / PRA22

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PRAMEF22 gene: 
    NM_001100631.1  

    Unigene Cluster for PRAMEF22:

    PRAME family member 22
    Hs.712522
    Unigene Representative Sequence: NM_001100631
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000376187(uc009vnq.1)
    miRNA
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      Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAMEF22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAMEF22

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PRAMEF22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGGTCTGA
    PRAMEF22 Expression
    About this image


    See PRAMEF22 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.712522
        SABiosciences Custom PCR Arrays for PRAMEF22
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for PRAMEF22 (if available)
    TreeFam Gene Tree for PRAMEF22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PRAMEF22 gene
    PRAMEF31 2  PRAMEF192  PRAMEF102  PRAMEF202  PRAMEF262  PRAMEF182  PRAMEF212  PRAMEF122  
    PRAMEF152  PRAMEF42  PRAMEF22  PRAMEF92  PRAMEF132  PRAME2  LRRC14B2  PRAMEF142  
    PRAMEF72  PRAMEF82  ENSG000002398102  PRAMEF172  PRAMEF52  LRRC142  PRAMEF112  PRAMEF162  
    PRAMEF12  PRAMEF62  
    18/26 SIMAP similar genes for PRAMEF22 using alignment to 1 protein entry:     PRA22_HUMAN(see all similar genes):
    PRAMEF3    PRAMEF18    PRAMEF19    PRAMEF25    PRAMEF10    PRAMEF1
    PRAMEF13    PRAMEF16    PRAMEF17    PRAMEF2    PRAMEF14    PRAMEF12
    PRAMEF20    PRAMEF21    PRAMEF24    PRAMEF7    PRAMEF8    PRAMEF15

    PRAMEF22 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/53 SNPs in PRAMEF22 are shown (see all 53)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017034331,2
    --13035221(+) AGACA-/TTTTTT 1 -- us2k10--------
    rs2013692591,2
    C--13036247(+) TGGAAA/TTGCGG 2 M L mis10--------
    rs2007614851,2
    F--13036294(+) GCCAGG/TCCCCT 2 R S mis11Minor allele frequency- T:0.01EU 1001
    rs2014923521,2
    C,F--13036296(+) CAGGCC/TCCTGT 2 P L mis11Minor allele frequency- T:0.05EU 923
    rs2000536051,2
    C--13036330(+) AAGAGA/GCAGAC 2 R syn10--------
    rs2008767561,2
    F--13036445(+) GGTGGG/ATCCAG 2 /I /V mis11Minor allele frequency- A:0.00EU 1033
    rs1996836761,2
    C--13036447(+) TGGGTC/GCAGCA 2 V syn10--------
    rs2005259861,2
    C--13036585(+) TGCTGA/GCCGTG 2 * W stg10--------
    rs777886411,2
    C--13036587(+) CTGGCC/TGTGTA 2 P L mis10--------
    rs2016362351,2
    C,F--13036654(+) ATCTCC/TGATGG 2 S syn11Minor allele frequency- T:0.14EU 1148

    HapMap Linkage Disequilibrium report for PRAMEF22 (13035543 - 13038381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/30 variations for PRAMEF22 (see all 30):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv14e199CNV Deletion23128226
    esv2675529CNV Deletion23128226
    dgv17e201CNV Deletion23290073
    nsv820528CNV Deletion20802225
    nsv508902CNV Insertion20534489
    dgv162n71CNV Loss21882294
    nsv2965CNV Loss18451855
    nsv832981CNV Loss17160897
    nsv433183CNV Loss18776910
    nsv870885CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for PRAMEF22:    About MalaCards
    melanoma    


    PRAMEF22 for disorders           About GeneDecksing


    Export disorders for PRAMEF22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PRAMEF22 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PRAMEF22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Duplication and positive selection among hominin-specific PRAME genes. (PubMed id 16159394)1 Birtle Z....Ponting C. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 653606 HGNC: 34393 Ensembl:ENSG00000204508 euGenes: HUgn653606 ECgene: PRAMEF22
    H-InvDB: PRAMEF22

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PRAMEF22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PRAMEF22 gene:
    Search GeneIP for patents involving PRAMEF22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for PRAMEF22
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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