PRAMEF2 Gene
protein-coding GIFtS: 41
GCID: GC01P012918
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PRAME family member 2
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Aliases
for PRAMEF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PRAME Family Member 21 2 | | FLJ435801 | | DJ845O24.32 | | RP5-845O24.12 |
Export aliases for PRAMEF2 gene to outside databasesPrevious GC identifers: GC01P012852 GC01P012070 |
Summaries
for PRAMEF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PRAMEF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRAMEF2 gene promoter:
Pbx1a Brachyury FOXO3 LCR-F1 GATA-1 Evi-1 YY1 FOXO3b PPAR-gamma1 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRAMEF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAMEF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.21PRAMEF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P012918: view genomic region
(about GC identifiers)
Start:
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12,916,941 bp from pter |
End:
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12,921,764 bp from pter |
Size:
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4,824 bases |
Orientation:
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plus strand |
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Proteins
for PRAMEF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRAM2_HUMAN, O60811 (See
protein sequence)Recommended Name: PRAME family member 2 Size: 474 amino acids; 54872 DaExplore the universe of human proteins at neXtProt for PRAMEF2: NX_O60811
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60811
PRAMEF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_075390.1
ENSEMBL proteins: ENSP00000240189
Human Recombinant Protein Products:
PRAMEF2 Antibody Products:
Assay Products for PRAMEF2: |
Protein
Domains /
Families
for PRAMEF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRAMEF2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60811ProtoNet protein and cluster: O60811 UniProtKB/Swiss-Prot: PRAM2_HUMAN, O60811Similarity: Belongs to the PRAME familySimilarity: Contains 2 LRR (leucine-rich) repeats |
Function
for PRAMEF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRAMEF2 (NM_023014) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAMEF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042974 | retinoic acid receptor binding |
IEA | -- |
PRAMEF2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for PRAMEF2:
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Pathways & Interactions
for PRAMEF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRAMEF2
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008284 | positive regulation of cell proliferation |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
IEA | -- | | GO:0045596 | negative regulation of cell differentiation |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IEA | -- | | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
IEA | -- |
PRAMEF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRAMEF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRAMEF2
Search CenterWatch for drugs/clinical trials and news about PRAMEF2 / PRAM2
|
Transcripts
for PRAMEF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRAMEF2 gene: NM_023014.1 Unigene Cluster for PRAMEF2: PRAME family member 2 Hs.104991 [show with all ESTs]Unigene Representative Sequence: AL0496741 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000240189(uc001aum.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRAMEF2 (NM_023014) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAMEF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF2 |
Additional cDNA sequence: AL049674.1 BC075008.2 BC075009.2 DQ786308.1 2 DOTS entries: DT.207193 DT.101975347 4 AceView cDNA sequences: NM_023013 AL049686 BV183315 AK125568
GeneLoc Exon Structure
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Expression
for PRAMEF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRAMEF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTATTGACG
About this image
See PRAMEF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRAMEF2
SOURCE GeneReport for Unigene cluster: Hs.104991
SABiosciences Custom PCR Arrays for PRAMEF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAMEF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PRAMEF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAMEF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAMEF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF2 |
Orthologs
for PRAMEF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for PRAMEF2 (if available)
TreeFam Gene Tree for PRAMEF2 (if available) |
Paralogs
for PRAMEF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRAMEF2 gene
- PRAMEF11 2 PRAMEF131 2 PRAMEF192 PRAMEF102 PRAMEF32 PRAMEF202 LOC6453592 PRAMEF182
- PRAMEF122 PRAMEF212 PRAMEF152 PRAMEF222 PRAMEF42 PRAMEF92 PRAME2 LRRC14B2
- PRAMEF142 PRAMEF72 PRAMEF82 PRAMEF172 PRAMEF52 LRRC142 PRAMEF112 PRAMEF162
- PRAMEF62
18/26 SIMAP similar genes for PRAMEF2 using alignment to 2 protein entries: PRAM2_HUMAN (see all proteins)
(see all similar genes):PRAMEF1 PRAMEF13 PRAMEF14 PRAMEF16 PRAMEF17 PRAMEF10
PRAMEF22 PRAMEF3 PRAMEF19 PRAMEF18 PRAMEF12 PRAMEF25
PRAMEF24 PRAMEF7 PRAMEF8 PRAMEF15 PRAMEF20 PRAMEF21
PRAMEF2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PRAMEF2
PGOHUM00000243901 PGOHUM00000244604
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Genomic Variants
for PRAMEF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRAMEF2 (12916941 - 12921764 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 15 variations for PRAMEF2
15 CNVs: 2298 6778 73028 58330 73032 22927 73023 48105 4403 0256 34692 3283 38931 30369 73029 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRAMEF2 |
|
Disorders
/ Diseases
for PRAMEF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRAMEF2 for disorders About GeneDecksing
1  disease for PRAMEF2: About MalaCardsmelanoma
Export disorders for PRAMEF2 gene to outside databases
|
Publications
for PRAMEF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRAMEF2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRAMEF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)1 Fortna A....Sikela J.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for PRAMEF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PRAMEF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRAMEF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRAMEF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PRAMEF2 gene:
Search GeneIP for patents involving PRAMEF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRAMEF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRAMEF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRAMEF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAMEF2 | | | OriGene Protein Over-expression Lysate for PRAMEF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRAMEF2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | PRAMEF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF2 |
|  |  |  | | | | Search ThermoFisher Antibodies for PRAMEF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF2 |
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