PRAMEF19 Gene
protein-coding GIFtS: 31
GCID: GC01M013694
|
|
PRAME family member 19
| |
Aliases
for PRAMEF19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PRAME Family Member 191 2 | | OTTHUMG000000079191 |
Export aliases for PRAMEF19 gene to outside databasesPrevious GC identifer: GC01M013567 |
Summaries
for PRAMEF19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PRAMEF19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRAMEF19 gene promoter:
GR HNF-4alpha2 GATA-1 HNF-4alpha1 PPAR-gamma1 HSF2 HSF1short PPAR-gamma2 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRAMEF19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAMEF19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.21PRAMEF19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M013694: view genomic region
(about GC identifiers)
Start:
|
13,694,889 bp from pter |
End:
|
13,698,405 bp from pter |
Size:
|
3,517 bases |
Orientation:
|
minus strand |
|
Proteins
for PRAMEF19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRA19_HUMAN, Q5SWL8 (See
protein sequence)Recommended Name: PRAME family member 19 Size: 410 amino acids; 47455 DaExplore the universe of human proteins at neXtProt for PRAMEF19: NX_Q5SWL8
PRAMEF19 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001093260.2
ENSEMBL proteins: ENSP00000365269 ENSP00000446004
Human Recombinant Protein Products:
PRAMEF19 Antibody Products:
Assay Products for PRAMEF19: |
Protein
Domains /
Families
for PRAMEF19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRAMEF19 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5SWL8ProtoNet protein and cluster: Q5SWL8 UniProtKB/Swiss-Prot: PRA19_HUMAN, Q5SWL8Similarity: Belongs to the PRAME familySimilarity: Contains 3 LRR (leucine-rich) repeats |
Function
for PRAMEF19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF19
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRAMEF19 (NM_001099790) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAMEF19 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF19 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF19 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042974 | retinoic acid receptor binding |
IEA | -- |
PRAMEF19 for ontologies About GeneDecksing
|
Pathways & Interactions
for PRAMEF19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRAMEF19
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008284 | positive regulation of cell proliferation |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
IEA | -- | | GO:0045596 | negative regulation of cell differentiation |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IEA | -- | | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
IEA | -- |
PRAMEF19 for ontologies About GeneDecksing
|
Drugs & Compounds
for PRAMEF19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRAMEF19
Search CenterWatch for drugs/clinical trials and news about PRAMEF19 / PRA19
|
Transcripts
for PRAMEF19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRAMEF19 gene: NM_001099790.1 Unigene Cluster for PRAMEF19: PRAME family member 19 Hs.700537 Unigene Representative Sequence: NM_0010997902 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376101 ENST00000540591(uc009vny.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF19
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF19
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRAMEF19 (NM_001099790) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAMEF19 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF19 |
GeneLoc Exon Structure
|
Expression
for PRAMEF19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRAMEF19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.700537
SABiosciences Custom PCR Arrays for PRAMEF19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAMEF19
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PRAMEF19 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAMEF19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAMEF19 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF19 |
Orthologs
for PRAMEF19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for PRAMEF19 (if available)
TreeFam Gene Tree for PRAMEF19 (if available) |
Paralogs
for PRAMEF19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRAMEF19 gene
- PRAMEF181 2 PRAMEF102 PRAMEF32 PRAMEF202 LOC6453592 PRAMEF122 PRAMEF212 PRAMEF152
- PRAMEF222 PRAMEF42 PRAMEF22 PRAMEF132 PRAMEF92 PRAME2 LRRC14B2 PRAMEF142
- PRAMEF72 PRAMEF82 PRAMEF172 PRAMEF52 LRRC142 PRAMEF112 PRAMEF162 PRAMEF12
- PRAMEF62
18/26 SIMAP similar genes for PRAMEF19 using alignment to 2 protein entries: PRA19_HUMAN (see all proteins)
(see all similar genes):PRAMEF18 PRAMEF22 PRAMEF3 PRAMEF25 PRAMEF10 PRAMEF1
PRAMEF2 PRAMEF13 PRAMEF16 PRAMEF17 PRAME PRAMEF14
PRAMEF12 PRAMEF24 PRAMEF7 PRAMEF8 PRAMEF20 PRAMEF21
PRAMEF19 for paralogs About GeneDecksing
|
Genomic Variants
for PRAMEF19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRAMEF19 (13694889 - 13698405 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 19 variations for PRAMEF19
15/18 CNVs (see all 18): 2298 0004 67406 74351 48105 74349 31605 30371 30369 73343 73182 73342 67518 84070 0256
1 Indel: 84071 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for PRAMEF19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRAMEF19 for disorders About GeneDecksing
1  disease for PRAMEF19: About MalaCardsmelanoma
Export disorders for PRAMEF19 gene to outside databases
|
Publications
for PRAMEF19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for PRAMEF19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRAMEF19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
|
External Searches for PRAMEF19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PRAMEF19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PRAMEF19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRAMEF19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PRAMEF19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PRAMEF19 gene:
Search GeneIP for patents involving PRAMEF19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRAMEF19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRAMEF19 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRAMEF19 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAMEF19 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRAMEF19 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF19 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF19 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PRAMEF19 | | OriGene Custom Protein Services for PRAMEF19 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PRAMEF19 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRAMEF19 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAMEF19 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PRAMEF19 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAMEF19 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAMEF19 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | PRAMEF19 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF19 |
|  |  |  | | | | Search ThermoFisher Antibodies for PRAMEF19 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF19 |
|
|
|
|
