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Aliases for PRAMEF11 Gene

Aliases for PRAMEF11 Gene

  • PRAME Family Member 11 2 3 5

External Ids for PRAMEF11 Gene

Previous GeneCards Identifiers for PRAMEF11 Gene

  • GC01M012821
  • GC01M012822
  • GC01U901232
  • GC01P013515
  • GC01M012884

Summaries for PRAMEF11 Gene

GeneCards Summary for PRAMEF11 Gene

PRAMEF11 (PRAME Family Member 11) is a Protein Coding gene. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF15.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF11 Gene

Genomics for PRAMEF11 Gene

Regulatory Elements for PRAMEF11 Gene

Enhancers for PRAMEF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F012470 1.7 FANTOM5 Ensembl ENCODE 16.2 +354.8 354786 11.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNORA59A PRAMEF12 PRAMEF11 LINC01784 PRAMEF30P HNRNPCL1 PRAMEF4 PRAMEF29P PRAMEF6 RNU5E-1
GH01F012432 1.7 FANTOM5 Ensembl ENCODE 16.2 +394.8 394759 7.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 PRAMEF12 LINC01784 PRAMEF11 PRAMEF30P PRAMEF4 HNRNPCL1 PRAMEF29P PRAMEF6 RNU5E-1 RNU5E-4P
GH01F011907 1.6 FANTOM5 ENCODE 16.2 +922.6 922613 3.1 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC UBIAD1 SNORA59A RNU5E-1 RNU5E-4P LOC102724659 PRAMEF12 PRAMEF4 LINC01784 PRAMEF30P HNRNPCL1
GH01F012046 1.2 Ensembl ENCODE 16.2 +784.0 783985 1.4 HDGF PKNOX1 ATF1 TBL1XR1 WRNIP1 SIN3A YBX1 RAD21 EGR1 ZNF143 RNU5E-1 RNU5E-4P LOC102724659 PRAMEF12 LINC01784 PRAMEF11 PRAMEF30P PRAMEF29P PRAMEF4 HNRNPCL1
GH01F011943 1 ENCODE 16.2 +886.9 886928 1.9 HDGF ATF1 PKNOX1 ARNT CREB3L1 FEZF1 GLI4 ZNF2 GLIS2 GATA2 ENSG00000226849 EXOSC10 MTHFR RNU5E-4P RNU5E-1 LOC102724659 PRAMEF30P LINC01784 PRAMEF4 HNRNPCL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRAMEF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRAMEF11 Gene

Chromosome:
1
Start:
12,824,380 bp from pter
End:
12,831,410 bp from pter
Size:
7,031 bases
Orientation:
Minus strand

Genomic View for PRAMEF11 Gene

Genes around PRAMEF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF11 Gene

Proteins for PRAMEF11 Gene

  • Protein details for PRAMEF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60813-PRA11_HUMAN
    Recommended name:
    PRAME family member 11
    Protein Accession:
    O60813

    Protein attributes for PRAMEF11 Gene

    Size:
    436 amino acids
    Molecular mass:
    50598 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA17880.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRAMEF11 Gene

Post-translational modifications for PRAMEF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF11 Gene

Domains & Families for PRAMEF11 Gene

Gene Families for PRAMEF11 Gene

Protein Domains for PRAMEF11 Gene

Suggested Antigen Peptide Sequences for PRAMEF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60813

UniProtKB/Swiss-Prot:

PRA11_HUMAN :
  • Belongs to the PRAME family.
  • Contains 6 LRR (leucine-rich) repeats.
Family:
  • Belongs to the PRAME family.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PRAMEF11: view

Function for PRAMEF11 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAMEF11 Gene

Localization for PRAMEF11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRAMEF11 gene
Compartment Confidence
mitochondrion 2
peroxisome 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAMEF11 Gene

Pathways & Interactions for PRAMEF11 Gene

SuperPathways for PRAMEF11 Gene

No Data Available

Interacting Proteins for PRAMEF11 Gene

Selected Interacting proteins: O60813-PRA11_HUMAN for PRAMEF11 Gene via IID

Gene Ontology (GO) - Biological Process for PRAMEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PRAMEF11: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF11 Gene

Transcripts for PRAMEF11 Gene

mRNA/cDNA for PRAMEF11 Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF11 Gene

No ASD Table

Relevant External Links for PRAMEF11 Gene

GeneLoc Exon Structure for
PRAMEF11
ECgene alternative splicing isoforms for
PRAMEF11

Expression for PRAMEF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PRAMEF11 Gene

mRNA differential expression in normal tissues according to GTEx for PRAMEF11 Gene

This gene is overexpressed in Testis (x42.3).

Protein differential expression in normal tissues from HIPED for PRAMEF11 Gene

This gene is overexpressed in Liver (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAMEF11 Gene



Protein tissue co-expression partners for PRAMEF11 Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAMEF11 Gene:

PRAMEF11

SOURCE GeneReport for Unigene cluster for PRAMEF11 Gene:

Hs.551617
genes like me logo Genes that share expression patterns with PRAMEF11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRAMEF11 Gene

Orthologs for PRAMEF11 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PRAMEF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 28 (a)
OneToMany
-- 35
  • 18 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm12790 35
OneToMany
Species where no ortholog for PRAMEF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAMEF11 Gene

ENSEMBL:
Gene Tree for PRAMEF11 (if available)
TreeFam:
Gene Tree for PRAMEF11 (if available)

Paralogs for PRAMEF11 Gene

Variants for PRAMEF11 Gene

Sequence variations from dbSNP and Humsavar for PRAMEF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10458473 -- 12,831,560(+) CTCCA(C/T)CCAGT upstream-variant-2KB
rs10458477 -- 12,831,748(+) CACTT(G/T)GGAAG upstream-variant-2KB
rs10864596 -- 12,825,688(+) TCCAC(C/T)TTAgg intron-variant
rs11121992 -- 12,829,391(+) ctctc(C/T)ctttc intron-variant, upstream-variant-2KB
rs11121993 -- 12,830,638(+) ACCAG(A/C/T)CACCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF11 Gene

Variant ID Type Subtype PubMed ID
esv3891303 CNV gain+loss 25118596
esv3891192 CNV gain+loss 25118596
esv3585243 CNV gain 21293372
esv3585242 CNV loss 21293372
esv3585241 CNV loss 21293372
esv3584476 CNV gain 24956385
esv3428728 CNV duplication 20981092
esv32750 CNV gain 17666407
esv28644 CNV gain+loss 19812545
esv2743853 CNV deletion 23290073
esv2669351 CNV deletion 23128226
esv2421662 OTHER complex 20811451
dgv9n27 CNV gain 19166990
dgv8n27 CNV loss 19166990
dgv7n111 CNV deletion 26073780
dgv6n27 CNV loss 19166990
dgv6n111 CNV duplication 26073780
dgv6e214 CNV loss 21293372
dgv6e201 CNV deletion 23290073
dgv5n27 CNV gain 19166990
dgv33n100 CNV loss 25217958
dgv32n100 CNV loss 25217958
dgv28n100 CNV gain+loss 25217958
dgv27n100 CNV gain+loss 25217958
dgv24n100 CNV loss 25217958
dgv21n100 CNV loss 25217958
dgv20n100 CNV loss 25217958
dgv1n64 CNV loss 17921354
dgv15n67 CNV loss 20364138
dgv14n67 CNV gain 20364138
dgv13n67 CNV loss 20364138
dgv129n54 CNV loss 21841781
dgv127n54 CNV loss 21841781
dgv125n54 CNV loss 21841781
dgv124n54 CNV loss 21841781
dgv123n54 CNV gain+loss 21841781
dgv120n54 CNV loss 21841781
dgv119n54 CNV loss 21841781
dgv118n54 CNV gain 21841781
dgv117n54 CNV gain+loss 21841781
dgv116n54 CNV loss 21841781
dgv114n54 CNV gain 21841781
nsv545445 CNV gain 21841781
nsv528703 CNV loss 19592680
nsv470696 CNV gain 18288195
nsv470695 CNV loss 18288195
nsv466394 CNV gain 19166990
nsv460350 CNV loss 19166990
nsv433182 CNV loss 18776910
nsv2965 CNV deletion 18451855
nsv1161165 CNV duplication 26073780
nsv1161161 CNV deletion 26073780
nsv1161105 CNV deletion 26073780
nsv1161102 CNV deletion 26073780
nsv1139469 CNV duplication 24896259
nsv1075770 CNV duplication 25765185
nsv1011540 CNV loss 25217958
nsv1010920 CNV gain+loss 25217958
nsv1006524 CNV gain+loss 25217958
nsv1002419 CNV gain 25217958
esv990214 CNV gain 20482838
esv3891748 CNV gain+loss 25118596
esv3891414 CNV gain+loss 25118596
nsv999194 CNV gain 25217958
nsv955255 CNV duplication 24416366
nsv945774 CNV duplication 23825009
nsv8768 CNV gain+loss 18304495
nsv832869 CNV gain+loss 17160897
nsv821559 CNV duplication 20802225
nsv817728 CNV gain+loss 17921354
nsv7172 OTHER inversion 18451855
nsv545490 CNV loss 21841781
nsv545486 CNV loss 21841781
nsv545462 CNV gain 21841781
nsv545457 CNV loss 21841781

Variation tolerance for PRAMEF11 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAMEF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAMEF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAMEF11 Gene

Disorders for PRAMEF11 Gene

Relevant External Links for PRAMEF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAMEF11

No disorders were found for PRAMEF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAMEF11 Gene

Publications for PRAMEF11 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for PRAMEF11 Gene

Sources for PRAMEF11 Gene

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