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Aliases for PRAMEF11 Gene

Aliases for PRAMEF11 Gene

  • PRAME Family Member 11 2 3 5

External Ids for PRAMEF11 Gene

Previous GeneCards Identifiers for PRAMEF11 Gene

  • GC01M012821
  • GC01M012822
  • GC01U901232
  • GC01P013515
  • GC01M012884

Summaries for PRAMEF11 Gene

GeneCards Summary for PRAMEF11 Gene

PRAMEF11 (PRAME Family Member 11) is a Protein Coding gene. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF20.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF11 Gene

Genomics for PRAMEF11 Gene

Regulatory Elements for PRAMEF11 Gene

Genomic Location for PRAMEF11 Gene

12,824,380 bp from pter
12,831,410 bp from pter
7,031 bases
Minus strand

Genomic View for PRAMEF11 Gene

Genes around PRAMEF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF11 Gene

Proteins for PRAMEF11 Gene

  • Protein details for PRAMEF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRAME family member 11
    Protein Accession:

    Protein attributes for PRAMEF11 Gene

    436 amino acids
    Molecular mass:
    50598 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAA17880.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for PRAMEF11 Gene

Proteomics data for PRAMEF11 Gene at MOPED

Post-translational modifications for PRAMEF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF11 Gene

Domains & Families for PRAMEF11 Gene

Gene Families for PRAMEF11 Gene

Protein Domains for PRAMEF11 Gene


Suggested Antigen Peptide Sequences for PRAMEF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRAME family.
  • Contains 6 LRR (leucine-rich) repeats.
  • Belongs to the PRAME family.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PRAMEF11: view

Function for PRAMEF11 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAMEF11 Gene

Localization for PRAMEF11 Gene

Subcellular locations from

Jensen Localization Image for PRAMEF11 Gene COMPARTMENTS Subcellular localization image for PRAMEF11 gene
Compartment Confidence
cytosol 2
mitochondrion 2
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAMEF11 Gene

Pathways & Interactions for PRAMEF11 Gene

SuperPathways for PRAMEF11 Gene

No Data Available

Interacting Proteins for PRAMEF11 Gene

Gene Ontology (GO) - Biological Process for PRAMEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PRAMEF11: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF11 Gene

Drugs & Compounds for PRAMEF11 Gene

No Compound Related Data Available

Transcripts for PRAMEF11 Gene

mRNA/cDNA for PRAMEF11 Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF11 Gene

No ASD Table

Relevant External Links for PRAMEF11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRAMEF11 Gene

mRNA expression in normal human tissues for PRAMEF11 Gene

mRNA differential expression in normal tissues according to GTEx for PRAMEF11 Gene

This gene is overexpressed in Testis (x42.3).

Protein differential expression in normal tissues from HIPED for PRAMEF11 Gene

This gene is overexpressed in Liver (65.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PRAMEF11 Gene

SOURCE GeneReport for Unigene cluster for PRAMEF11 Gene Hs.551617

genes like me logo Genes that share expression patterns with PRAMEF11: view

Protein tissue co-expression partners for PRAMEF11 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PRAMEF11 Gene

Orthologs for PRAMEF11 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PRAMEF11 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gm12790 36
(Pan troglodytes)
Mammalia -- 36
  • 28 (a)
-- 36
  • 18 (a)
Species with no ortholog for PRAMEF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAMEF11 Gene

Gene Tree for PRAMEF11 (if available)
Gene Tree for PRAMEF11 (if available)

Paralogs for PRAMEF11 Gene

genes like me logo Genes that share paralogs with PRAMEF11: view

Variants for PRAMEF11 Gene

Sequence variations from dbSNP and Humsavar for PRAMEF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1819129 -- 12,825,726(+) cccag(A/C)acttt intron-variant
rs1830486 -- 12,828,529(-) GGGCT(A/G/T)GATGC reference, synonymous-codon
rs1626807 -- 12,831,305(-) CAGTC(A/G)GTCTG intron-variant
rs1628491 -- 12,831,128(-) gagca(A/G)tgact intron-variant
rs1856628 -- 12,831,350(-) GTAAG(C/T)CACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF11 Gene

Variant ID Type Subtype PubMed ID
dgv20e1 CNV Complex 17122850
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
nsv466394 CNV Gain 19166990
essv3598 CNV CNV 17122850
dgv22e1 CNV Complex 17122850
dgv146n71 CNV Gain 21882294
nsv832869 CNV Gain+Loss 17160897
dgv23e1 CNV Complex 17122850
nsv470695 CNV Loss 18288195
nsv528703 CNV Loss 19592680
dgv24e1 CNV Complex 17122850
dgv147n71 CNV Gain 21882294
dgv5n27 CNV Gain 19166990
nsv871936 CNV Gain 21882294
dgv6n27 CNV Loss 19166990
dgv149n71 CNV Gain 21882294
nsv517190 CNV Gain+Loss 19592680
nsv821559 CNV Duplication 20802225
dgv13n67 CNV Loss 20364138
esv28644 CNV Gain+Loss 19812545
esv990214 CNV Gain 20482838
esv2421662 OTHER Complex 20811451
nsv871497 CNV Loss 21882294
nsv8768 CNV Gain+Loss 18304495
dgv14n67 CNV Gain 20364138
esv32750 CNV Gain 17666407
dgv151n71 CNV Loss 21882294
dgv152n71 CNV Gain+Loss 21882294
dgv153n71 CNV Gain 21882294
dgv154n71 CNV Gain 21882294
dgv155n71 CNV Gain+Loss 21882294
dgv156n71 CNV Gain 21882294
dgv157n71 CNV Gain+Loss 21882294
dgv158n71 CNV Gain 21882294
nsv871956 CNV Loss 21882294
dgv159n71 CNV Loss 21882294
dgv15n67 CNV Loss 20364138
esv2669351 CNV Deletion 23128226
dgv25e1 CNV Complex 17122850
nsv470696 CNV Gain 18288195
dgv8n27 CNV Loss 19166990
dgv9n27 CNV Gain 19166990
nsv817728 CNV Gain+Loss 17921354
nsv870489 CNV Gain+Loss 21882294
dgv1n64 CNV Loss 17921354
nsv871633 CNV Gain 21882294
dgv161n71 CNV Loss 21882294
nsv2965 CNV Loss 18451855
esv2743853 CNV Deletion 23290073
nsv871161 CNV Gain+Loss 21882294
nsv7172 OTHER Inversion 18451855
nsv460350 CNV Loss 19166990
nsv433182 CNV Loss 18776910
nsv871065 CNV Gain 21882294
dgv162n71 CNV Loss 21882294
dgv16e201 CNV Deletion 23290073

Variation tolerance for PRAMEF11 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PRAMEF11 Gene

Disorders for PRAMEF11 Gene

Relevant External Links for PRAMEF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRAMEF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAMEF11 Gene

Publications for PRAMEF11 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PRAMEF11 Gene

Sources for PRAMEF11 Gene