PRAMEF1 Gene
protein-coding GIFtS: 41
GCID: GC01P012853
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PRAME family member 1
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Aliases
for PRAMEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PRAME Family Member 11 2 |
Export aliases for PRAMEF1 gene to outside databasesPrevious GC identifers: GC01P012786 GC01P012005 |
Summaries
for PRAMEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PRAMEF1:
This gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed inmany cancers but may function in reproductive tissues during development. (provided by RefSeq, Sep 2011)
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Genomic Views
for PRAMEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PRAMEF1 gene promoter:
HOXA9B HOXA9 GR E47 PPAR-alpha PPAR-gamma1 PPAR-gamma2 GR-alpha Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PRAMEF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PRAMEF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.21PRAMEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P012853: view genomic region
(about GC identifiers)
Start:
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12,851,546 bp from pter |
End:
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12,856,777 bp from pter |
Size:
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5,232 bases |
Orientation:
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plus strand |
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Proteins
for PRAMEF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PRAM1_HUMAN, O95521 (See
protein sequence)Recommended Name: PRAME family member 1 Size: 474 amino acids; 55162 Da
Secondary accessions: Q9UQP2Explore the universe of human proteins at neXtProt for PRAMEF1: NX_O95521
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95521
PRAMEF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_075389.1
ENSEMBL proteins: ENSP00000332134 ENSP00000383616
Human Recombinant Protein Products:
PRAMEF1 Antibody Products:
Assay Products for PRAMEF1: |
Protein
Domains /
Families
for PRAMEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PRAMEF1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95521ProtoNet protein and cluster: O95521 UniProtKB/Swiss-Prot: PRAM1_HUMAN, O95521Similarity: Belongs to the PRAME familySimilarity: Contains 2 LRR (leucine-rich) repeats |
Function
for PRAMEF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PRAMEF1 (NM_023013) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAMEF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042974 | retinoic acid receptor binding |
IEA | -- |
PRAMEF1 for ontologies About GeneDecksing
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Pathways & Interactions
for PRAMEF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PRAMEF1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for PRAMEF1 (ENSP000003321344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008284 | positive regulation of cell proliferation |
IEA | -- | | GO:0043066 | negative regulation of apoptotic process |
IEA | -- | | GO:0045596 | negative regulation of cell differentiation |
IEA | -- | | GO:0045892 | negative regulation of transcription, DNA-dependent |
IEA | -- | | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway |
IEA | -- |
PRAMEF1 for ontologies About GeneDecksing
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Drugs & Compounds
for PRAMEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PRAMEF1
Search CenterWatch for drugs/clinical trials and news about PRAMEF1 / PRAM1
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Transcripts
for PRAMEF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PRAMEF1 gene: NM_023013.2 Unigene Cluster for PRAMEF1: PRAME family member 1 Hs.454859 [show with all ESTs]Unigene Representative Sequence: NM_0230132 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332296(uc001auj.2) ENST00000400814
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PRAMEF1 (NM_023013) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PRAMEF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF1 |
Additional cDNA sequence: AK125568.1 AL049686.1 BC040902.1 BC144199.1 3 DOTS entries: DT.101975347 DT.97779824 DT.207193 4 AceView cDNA sequences: AL049686 NM_023013 BV183315 AK125568
GeneLoc Exon Structure
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Expression
for PRAMEF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PRAMEF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACTTAAAG
About this image
See PRAMEF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PRAMEF1
SOURCE GeneReport for Unigene cluster: Hs.454859
SABiosciences Custom PCR Arrays for PRAMEF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAMEF1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat PRAMEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PRAMEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PRAMEF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF1 |
Orthologs
for PRAMEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for PRAMEF1 (if available)
TreeFam Gene Tree for PRAMEF1 (if available) |
Paralogs
for PRAMEF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PRAMEF1 gene
- PRAMEF131 2 PRAMEF21 2 PRAMEF192 PRAMEF102 PRAMEF32 PRAMEF202 LOC6453592 PRAMEF182
- PRAMEF122 PRAMEF212 PRAMEF152 PRAMEF222 PRAMEF42 PRAMEF92 PRAME2 LRRC14B2
- PRAMEF142 PRAMEF72 PRAMEF82 PRAMEF172 PRAMEF52 LRRC142 PRAMEF112 PRAMEF162
- PRAMEF62
18/26 SIMAP similar genes for PRAMEF1 using alignment to 3 protein entries: PRAM1_HUMAN (see all proteins)
(see all similar genes):PRAMEF13 PRAMEF2 PRAMEF14 PRAMEF10 PRAMEF17 PRAMEF22
PRAMEF3 PRAMEF16 PRAMEF18 PRAMEF19 PRAMEF12 PRAMEF25
PRAMEF24 PRAMEF8 PRAMEF7 PRAMEF15 PRAMEF20 PRAMEF21
PRAMEF1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PRAMEF1
PGOHUM00000243902 PGOHUM00000244603
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Genomic Variants
for PRAMEF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PRAMEF1 (12851546 - 12856777 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for PRAMEF1
14 CNVs: 84050 2298 74333 53549 29829 6778 73028 74334 4403 73021 3283 38811 30369 53220 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PRAMEF1 |
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Disorders
/ Diseases
for PRAMEF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PRAMEF1 for disorders About GeneDecksing
1  disease for PRAMEF1: About MalaCardsmelanoma
Export disorders for PRAMEF1 gene to outside databases
|
Publications
for PRAMEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PRAMEF1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PRAMEF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Duplication and positive selection among hominin-specific PRAME genes. (PubMed id 16159394)1 Birtle Z....Ponting C. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for PRAMEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PRAMEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing PRAMEF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PRAMEF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for PRAMEF1 gene:
Search GeneIP for patents involving PRAMEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PRAMEF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PRAMEF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PRAMEF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PRAMEF1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PRAMEF1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PRAMEF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | PRAMEF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAMEF1 |
|  |  |  | | | | Search ThermoFisher Antibodies for PRAMEF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PRAMEF1 |
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