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Aliases for PRAMEF1 Gene

Aliases for PRAMEF1 Gene

  • PRAME Family Member 1 2 3

External Ids for PRAMEF1 Gene

Previous GeneCards Identifiers for PRAMEF1 Gene

  • GC01P012786
  • GC01P012005

Summaries for PRAMEF1 Gene

Entrez Gene Summary for PRAMEF1 Gene

  • This gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed in many cancers but may function in reproductive tissues during development. Alternative promoter usage generates two transcript variants, which encode different isoforms. [provided by RefSeq, Jun 2014]

GeneCards Summary for PRAMEF1 Gene

PRAMEF1 (PRAME Family Member 1) is a Protein Coding gene. Diseases associated with PRAMEF1 include melanoma. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF20.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF1 Gene

Genomics for PRAMEF1 Gene

Regulatory Elements for PRAMEF1 Gene

Genomic Location for PRAMEF1 Gene

Start:
12,791,397 bp from pter
End:
12,796,628 bp from pter
Size:
5,232 bases
Orientation:
Plus strand

Genomic View for PRAMEF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRAMEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF1 Gene

Proteins for PRAMEF1 Gene

  • Protein details for PRAMEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95521-PRAM1_HUMAN
    Recommended name:
    PRAME family member 1
    Protein Accession:
    O95521
    Secondary Accessions:
    • Q9UQP2

    Protein attributes for PRAMEF1 Gene

    Size:
    474 amino acids
    Molecular mass:
    55162 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAMEF1 Gene

Proteomics data for PRAMEF1 Gene at MOPED

Post-translational modifications for PRAMEF1 Gene

  • Ubiquitination at Lys99
  • Modification sites at PhosphoSitePlus

Other Protein References for PRAMEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF1 Gene

Domains for PRAMEF1 Gene

Protein Domains for PRAMEF1 Gene

Suggested Antigen Peptide Sequences for PRAMEF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95521

UniProtKB/Swiss-Prot:

PRAM1_HUMAN :
  • O95521
Family:
  • Belongs to the PRAME family.
Similarity:
  • Contains 2 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PRAMEF1: view

No data available for Gene Families for PRAMEF1 Gene

Function for PRAMEF1 Gene

Gene Ontology (GO) - Molecular Function for PRAMEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042974 retinoic acid receptor binding IEA --
genes like me logo Genes that share ontologies with PRAMEF1: view

miRNA for PRAMEF1 Gene

miRTarBase miRNAs that target PRAMEF1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRAMEF1 Gene

Localization for PRAMEF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRAMEF1 Gene COMPARTMENTS Subcellular localization image for PRAMEF1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAMEF1 Gene

Pathways for PRAMEF1 Gene

SuperPathways for PRAMEF1 Gene

No Data Available

Interacting Proteins for PRAMEF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332134%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000332134 for PRAMEF1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for PRAMEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0043066 negative regulation of apoptotic process IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PRAMEF1: view

No data available for Pathways by source for PRAMEF1 Gene

Transcripts for PRAMEF1 Gene

mRNA/cDNA for PRAMEF1 Gene

(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRAMEF1 Gene

PRAME family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF1 Gene

No ASD Table

Relevant External Links for PRAMEF1 Gene

GeneLoc Exon Structure for
PRAMEF1
ECgene alternative splicing isoforms for
PRAMEF1

Expression for PRAMEF1 Gene

mRNA expression in normal human tissues for PRAMEF1 Gene

mRNA differential expression in normal tissues according to GTEx for PRAMEF1 Gene

This gene is overexpressed in Testis (36.9).

SOURCE GeneReport for Unigene cluster for PRAMEF1 Gene Hs.454859

genes like me logo Genes that share expressions with PRAMEF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for PRAMEF1 Gene

Orthologs for PRAMEF1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PRAMEF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 90 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm12790 36
  • 34 (a)
OneToMany
Species with no ortholog for PRAMEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAMEF1 Gene

ENSEMBL:
Gene Tree for PRAMEF1 (if available)
TreeFam:
Gene Tree for PRAMEF1 (if available)

Paralogs for PRAMEF1 Gene

Pseudogenes.org Pseudogenes for PRAMEF1 Gene

genes like me logo Genes that share paralogs with PRAMEF1: view

Variants for PRAMEF1 Gene

Sequence variations from dbSNP and Humsavar for PRAMEF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1052908 - 12,795,729(-) CAATT(G/T)CTGCC reference, missense
rs1063755 -- 12,793,248(+) CCACC(C/G)AGACT upstream-variant-2KB, reference, synonymous-codon
rs1063759 -- 12,793,427(+) TCTGG(G/T)ATCAC upstream-variant-2KB, reference, missense
rs1063763 -- 12,794,009(+) CAGAG(A/G)CCACG upstream-variant-2KB, reference, missense
rs1063766 -- 12,794,200(+) ACGCC(A/G)ATTAA upstream-variant-2KB, synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF1 Gene

Variant ID Type Subtype PubMed ID
dgv20e1 CNV Complex 17122850
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
nsv466394 CNV Gain 19166990
essv3598 CNV CNV 17122850
dgv22e1 CNV Complex 17122850
dgv146n71 CNV Gain 21882294
nsv832869 CNV Gain+Loss 17160897
dgv23e1 CNV Complex 17122850
nsv470695 CNV Loss 18288195
nsv528703 CNV Loss 19592680
dgv24e1 CNV Complex 17122850
dgv147n71 CNV Gain 21882294
dgv5n27 CNV Gain 19166990
dgv148n71 CNV Loss 21882294
nsv871936 CNV Gain 21882294
dgv6n27 CNV Loss 19166990
dgv149n71 CNV Gain 21882294
nsv517190 CNV Gain+Loss 19592680
nsv821559 CNV Duplication 20802225
dgv13n67 CNV Loss 20364138
nsv471539 CNV Duplication 19718026
esv28644 CNV Gain+Loss 19812545
esv990214 CNV Gain 20482838
esv2421662 OTHER Complex 20811451
dgv150n71 CNV Loss 21882294
nsv871497 CNV Loss 21882294
nsv442270 CNV CNV 18776908
nsv8768 CNV Gain+Loss 18304495
dgv14n67 CNV Gain 20364138
esv32750 CNV Gain 17666407
dgv151n71 CNV Loss 21882294
dgv152n71 CNV Gain+Loss 21882294
dgv153n71 CNV Gain 21882294
dgv154n71 CNV Gain 21882294
dgv155n71 CNV Gain+Loss 21882294
dgv156n71 CNV Gain 21882294
dgv157n71 CNV Gain+Loss 21882294
dgv158n71 CNV Gain 21882294
nsv871956 CNV Loss 21882294
dgv159n71 CNV Loss 21882294
nsv870617 CNV Loss 21882294
dgv15n67 CNV Loss 20364138
esv2669351 CNV Deletion 23128226
dgv160n71 CNV Gain 21882294
nsv870688 CNV Gain+Loss 21882294
dgv25e1 CNV Complex 17122850

Relevant External Links for PRAMEF1 Gene

HapMap Linkage Disequilibrium report
PRAMEF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAMEF1 Gene

Disorders for PRAMEF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PRAMEF1 Gene including...

Search for PRAMEF1 Gene in MalaCards »
genes like me logo Genes that share disorders with PRAMEF1: view

No data available for UniProtKB/Swiss-Prot for PRAMEF1 Gene

Publications for PRAMEF1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PMID: 23000965) Povlsen L.K. … Choudhary C. (Nat. Cell Biol. 2012) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Duplication and positive selection among hominin-specific PRAME genes. (PMID: 16159394) Birtle Z. … Ponting C. (BMC Genomics 2005) 3

Products for PRAMEF1 Gene

Sources for PRAMEF1 Gene

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