Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRAMEF1 Gene

Aliases for PRAMEF1 Gene

  • PRAME Family Member 1 2 3 5

External Ids for PRAMEF1 Gene

Previous GeneCards Identifiers for PRAMEF1 Gene

  • GC01P012786
  • GC01P012005

Summaries for PRAMEF1 Gene

Entrez Gene Summary for PRAMEF1 Gene

  • This gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed in many cancers but may function in reproductive tissues during development. Alternative promoter usage generates two transcript variants, which encode different isoforms. [provided by RefSeq, Jun 2014]

GeneCards Summary for PRAMEF1 Gene

PRAMEF1 (PRAME Family Member 1) is a Protein Coding gene. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF20.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAMEF1 Gene

Genomics for PRAMEF1 Gene

Regulatory Elements for PRAMEF1 Gene

Enhancers for PRAMEF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PRAMEF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PRAMEF1 Gene

12,791,397 bp from pter
12,796,628 bp from pter
5,232 bases
Plus strand

Genomic View for PRAMEF1 Gene

Genes around PRAMEF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAMEF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAMEF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAMEF1 Gene

Proteins for PRAMEF1 Gene

  • Protein details for PRAMEF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PRAME family member 1
    Protein Accession:
    Secondary Accessions:
    • Q9UQP2

    Protein attributes for PRAMEF1 Gene

    474 amino acids
    Molecular mass:
    55149 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PRAMEF1 Gene

Proteomics data for PRAMEF1 Gene at MOPED

Post-translational modifications for PRAMEF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRAMEF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PRAMEF1 Gene

Domains & Families for PRAMEF1 Gene

Gene Families for PRAMEF1 Gene

Protein Domains for PRAMEF1 Gene


Suggested Antigen Peptide Sequences for PRAMEF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRAME family.
  • Contains 2 LRR (leucine-rich) repeats.
  • Belongs to the PRAME family.
  • Contains 2 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PRAMEF1: view

Function for PRAMEF1 Gene

genes like me logo Genes that share phenotypes with PRAMEF1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRAMEF1 Gene

Localization for PRAMEF1 Gene

Subcellular locations from

Jensen Localization Image for PRAMEF1 Gene COMPARTMENTS Subcellular localization image for PRAMEF1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PRAMEF1 Gene

Pathways & Interactions for PRAMEF1 Gene

SuperPathways for PRAMEF1 Gene

No Data Available

Interacting Proteins for PRAMEF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000332134 for PRAMEF1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for PRAMEF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IEA --
GO:0045596 negative regulation of cell differentiation IEA --
GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with PRAMEF1: view

No data available for Pathways by source and SIGNOR curated interactions for PRAMEF1 Gene

Drugs & Compounds for PRAMEF1 Gene

No Compound Related Data Available

Transcripts for PRAMEF1 Gene

mRNA/cDNA for PRAMEF1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRAMEF1 Gene

PRAME family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRAMEF1 Gene

No ASD Table

Relevant External Links for PRAMEF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRAMEF1 Gene

mRNA expression in normal human tissues for PRAMEF1 Gene

mRNA differential expression in normal tissues according to GTEx for PRAMEF1 Gene

This gene is overexpressed in Testis (x36.9).

SOURCE GeneReport for Unigene cluster for PRAMEF1 Gene Hs.454859

genes like me logo Genes that share expression patterns with PRAMEF1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PRAMEF1 Gene

Orthologs for PRAMEF1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for PRAMEF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gm12790 36
  • 34 (a)
(Pan troglodytes)
Mammalia -- 36
  • 90 (a)
Species with no ortholog for PRAMEF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAMEF1 Gene

Gene Tree for PRAMEF1 (if available)
Gene Tree for PRAMEF1 (if available)

Paralogs for PRAMEF1 Gene Pseudogenes for PRAMEF1 Gene

genes like me logo Genes that share paralogs with PRAMEF1: view

Variants for PRAMEF1 Gene

Sequence variations from dbSNP and Humsavar for PRAMEF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1063776 - 12,794,381(-) TCCTT(C/G/T)GAGTT upstream-variant-2KB, reference, missense
VAR_034397 -
VAR_034398 -
VAR_034399 -
rs1063767 - 12,794,237(+) TATAC(A/C/G)TGAAT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRAMEF1 Gene

Variant ID Type Subtype PubMed ID
dgv20e1 CNV Complex 17122850
dgv21e1 CNV Complex 17122850
nsv428410 CNV Gain+Loss 18775914
nsv466394 CNV Gain 19166990
essv3598 CNV CNV 17122850
dgv22e1 CNV Complex 17122850
dgv146n71 CNV Gain 21882294
nsv832869 CNV Gain+Loss 17160897
dgv23e1 CNV Complex 17122850
nsv470695 CNV Loss 18288195
nsv528703 CNV Loss 19592680
dgv24e1 CNV Complex 17122850
dgv147n71 CNV Gain 21882294
dgv5n27 CNV Gain 19166990
dgv148n71 CNV Loss 21882294
nsv871936 CNV Gain 21882294
dgv6n27 CNV Loss 19166990
dgv149n71 CNV Gain 21882294
nsv517190 CNV Gain+Loss 19592680
nsv821559 CNV Duplication 20802225
dgv13n67 CNV Loss 20364138
nsv471539 CNV Duplication 19718026
esv28644 CNV Gain+Loss 19812545
esv990214 CNV Gain 20482838
esv2421662 OTHER Complex 20811451
dgv150n71 CNV Loss 21882294
nsv871497 CNV Loss 21882294
nsv442270 CNV CNV 18776908
nsv8768 CNV Gain+Loss 18304495
dgv14n67 CNV Gain 20364138
esv32750 CNV Gain 17666407
dgv151n71 CNV Loss 21882294
dgv152n71 CNV Gain+Loss 21882294
dgv153n71 CNV Gain 21882294
dgv154n71 CNV Gain 21882294
dgv155n71 CNV Gain+Loss 21882294
dgv156n71 CNV Gain 21882294
dgv157n71 CNV Gain+Loss 21882294
dgv158n71 CNV Gain 21882294
nsv871956 CNV Loss 21882294
dgv159n71 CNV Loss 21882294
nsv870617 CNV Loss 21882294
dgv15n67 CNV Loss 20364138
esv2669351 CNV Deletion 23128226
dgv160n71 CNV Gain 21882294
nsv870688 CNV Gain+Loss 21882294
dgv25e1 CNV Complex 17122850

Variation tolerance for PRAMEF1 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAMEF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAMEF1 Gene

Disorders for PRAMEF1 Gene

Relevant External Links for PRAMEF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PRAMEF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRAMEF1 Gene

Publications for PRAMEF1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Duplication and positive selection among hominin-specific PRAME genes. (PMID: 16159394) Birtle Z. … Ponting C. (BMC Genomics 2005) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for PRAMEF1 Gene

Sources for PRAMEF1 Gene