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Aliases for PRAME Gene

Aliases for PRAME Gene

  • Preferentially Expressed Antigen In Melanoma 2 3 5
  • Preferentially Expressed Antigen Of Melanoma 3 4
  • Cancer/Testis Antigen 130 2 3
  • Opa-Interacting Protein 4 3 4
  • OIP-4 3 4
  • MAPE 3 4
  • OIP4 3 4
  • Melanoma Antigen Preferentially Expressed In Tumors 3
  • Opa-Interacting Protein OIP4 3
  • CT130 3

External Ids for PRAME Gene

Previous HGNC Symbols for PRAME Gene

  • MAPE

Previous GeneCards Identifiers for PRAME Gene

  • GC22M019588
  • GC22M021214
  • GC22M020673
  • GC22M022890
  • GC22M005860

Summaries for PRAME Gene

Entrez Gene Summary for PRAME Gene

  • This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for PRAME Gene

PRAME (Preferentially Expressed Antigen In Melanoma) is a Protein Coding gene. Diseases associated with PRAME include Melanoma and Leukemia, Chronic Myeloid, Somatic. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF12.

UniProtKB/Swiss-Prot for PRAME Gene

  • Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Gene Wiki entry for PRAME Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAME Gene

Genomics for PRAME Gene

Regulatory Elements for PRAME Gene

Enhancers for PRAME Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PRAME on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PRAME gene promoter:

Genomic Location for PRAME Gene

Chromosome:
22
Start:
22,547,696 bp from pter
End:
22,559,361 bp from pter
Size:
11,666 bases
Orientation:
Minus strand

Genomic View for PRAME Gene

Genes around PRAME on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRAME Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRAME Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAME Gene

Proteins for PRAME Gene

  • Protein details for PRAME Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78395-PRAME_HUMAN
    Recommended name:
    Melanoma antigen preferentially expressed in tumors
    Protein Accession:
    P78395
    Secondary Accessions:
    • B2R6Y7
    • O43481
    • Q8IXN8

    Protein attributes for PRAME Gene

    Size:
    509 amino acids
    Molecular mass:
    57890 Da
    Quaternary structure:
    • Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.
    Miscellaneous:
    • Tumor antigen recognized by cytolytic T lymphocytes.

neXtProt entry for PRAME Gene

Post-translational modifications for PRAME Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PRAME Gene

Domains & Families for PRAME Gene

Gene Families for PRAME Gene

Protein Domains for PRAME Gene

Graphical View of Domain Structure for InterPro Entry

P78395

UniProtKB/Swiss-Prot:

PRAME_HUMAN :
  • Belongs to the PRAME family.
  • Contains 4 LRR (leucine-rich) repeats.
Family:
  • Belongs to the PRAME family.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with PRAME: view

Function for PRAME Gene

Molecular function for PRAME Gene

GENATLAS Biochemistry:
preferentially expressed antigen in melanoma
UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Gene Ontology (GO) - Molecular Function for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16179254
GO:0042974 retinoic acid receptor binding IDA 16179254
genes like me logo Genes that share ontologies with PRAME: view

Phenotypes for PRAME Gene

genes like me logo Genes that share phenotypes with PRAME: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PRAME Gene

Localization for PRAME Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAME Gene

Nucleus. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRAME Gene COMPARTMENTS Subcellular localization image for PRAME gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PRAME: view

Pathways & Interactions for PRAME Gene

SuperPathways for PRAME Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0008284 positive regulation of cell proliferation IDA 16179254
GO:0030154 cell differentiation IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with PRAME: view

No data available for Pathways by source and SIGNOR curated interactions for PRAME Gene

Drugs & Compounds for PRAME Gene

(1) Drugs for PRAME Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Azacitidine Approved, Investigational Pharma 482

(2) Additional Compounds for PRAME Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PRAME: view

Transcripts for PRAME Gene

Unigene Clusters for PRAME Gene

Preferentially expressed antigen in melanoma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRAME Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - -
SP7: -
SP8: - -

Relevant External Links for PRAME Gene

GeneLoc Exon Structure for
PRAME
ECgene alternative splicing isoforms for
PRAME

Expression for PRAME Gene

mRNA expression in normal human tissues for PRAME Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAME Gene

This gene is overexpressed in Testis (x43.8).

Protein differential expression in normal tissues from HIPED for PRAME Gene

This gene is overexpressed in Spinal cord (47.5) and Blymphocyte (21.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRAME Gene



Protein tissue co-expression partners for PRAME Gene

NURSA nuclear receptor signaling pathways regulating expression of PRAME Gene:

PRAME

SOURCE GeneReport for Unigene cluster for PRAME Gene:

Hs.30743

mRNA Expression by UniProt/SwissProt for PRAME Gene:

P78395-PRAME_HUMAN
Tissue specificity: Expressed in testis. Detected in samples of kidney, brain and skin.
genes like me logo Genes that share expression patterns with PRAME: view

Primer Products

Orthologs for PRAME Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRAME Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100300040 34
  • 71.49 (n)
  • 65.28 (a)
-- 35
  • 66 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
PRAME 35
  • 62 (a)
OneToMany
PRAME 35
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PRAME 34
  • 79.36 (n)
  • 69.74 (a)
PRAME 35
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRAME 34
  • 98.23 (n)
  • 96.07 (a)
PRAME 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRAME 35
  • 20 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AV320801 35
  • 32 (a)
OneToMany
Gm15023 35
  • 32 (a)
OneToMany
Gm5128 35
  • 32 (a)
OneToMany
Gm7903 35
  • 32 (a)
OneToMany
Prame 35
  • 34 (a)
OneToMany
Pramel3 35
  • 32 (a)
OneToMany
Species where no ortholog for PRAME was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAME Gene

ENSEMBL:
Gene Tree for PRAME (if available)
TreeFam:
Gene Tree for PRAME (if available)

Paralogs for PRAME Gene

genes like me logo Genes that share paralogs with PRAME: view

Variants for PRAME Gene

Sequence variations from dbSNP and Humsavar for PRAME Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_021258 -
VAR_062137 -
rs5996141 -- 22,551,642(+) AAAAA(A/C)AACAT intron-variant
rs5996147 -- 22,556,255(+) ACCTC(A/G)GCCTC intron-variant, upstream-variant-2KB
rs16989530 -- 22,550,459(+) ACTTC(A/G)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAME Gene

Variant ID Type Subtype PubMed ID
dgv2442n106 CNV deletion 24896259
dgv38n64 CNV loss 17921354
dgv39n64 CNV loss 17921354
dgv4505n100 CNV loss 25217958
dgv4506n100 CNV loss 25217958
dgv4507n100 CNV loss 25217958
dgv4510n100 CNV loss 25217958
dgv4511n100 CNV gain 25217958
dgv548n27 CNV loss 19166990
dgv550n27 CNV loss 19166990
dgv551n27 CNV loss 19166990
dgv555n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv558n27 CNV loss 19166990
dgv560n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv8004n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8010n54 CNV loss 21841781
dgv8012n54 CNV loss 21841781
dgv8014n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv8016n54 CNV loss 21841781
dgv8017n54 CNV gain+loss 21841781
dgv8018n54 CNV gain 21841781
dgv8019n54 CNV gain 21841781
dgv8020n54 CNV loss 21841781
dgv8021n54 CNV gain+loss 21841781
dgv8022n54 CNV loss 21841781
dgv8023n54 CNV loss 21841781
dgv826e214 CNV loss 21293372
esv1007524 CNV gain 20482838
esv2422480 CNV deletion 17116639
esv3568288 CNV loss 25503493
esv3568289 CNV loss 25503493
esv3568290 CNV loss 25503493
esv3647369 CNV loss 21293372
nsv1060145 CNV gain 25217958
nsv1063128 CNV gain+loss 25217958
nsv1072205 CNV deletion 25765185
nsv433336 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459421 CNV gain 19166990
nsv459539 CNV loss 19166990
nsv459548 CNV loss 19166990
nsv469742 CNV gain+loss 16826518
nsv479710 CNV novel sequence insertion 20440878
nsv508727 CNV insertion 20534489
nsv511072 OTHER complex 20534489
nsv514963 CNV gain+loss 21397061
nsv526328 CNV gain 19592680
nsv588348 CNV gain 21841781
nsv588469 CNV loss 21841781
nsv588472 CNV loss 21841781
nsv588474 CNV gain 21841781
nsv588475 CNV gain 21841781
nsv588478 CNV gain+loss 21841781
nsv588484 CNV loss 21841781
nsv588491 CNV gain+loss 21841781
nsv588492 CNV loss 21841781
nsv588493 CNV loss 21841781
nsv588498 CNV gain 21841781
nsv588499 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817957 CNV gain 17921354
nsv819428 CNV gain 19587683
nsv821694 CNV loss 15273396
nsv828977 CNV loss 20364138
nsv828979 CNV gain+loss 20364138
nsv834149 CNV loss 17160897
nsv834150 CNV loss 17160897

Variation tolerance for PRAME Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.04; 50.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRAME Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PRAME

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAME Gene

Disorders for PRAME Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRAME Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
leukemia, chronic myeloid, somatic
  • leukemia, chronic myeloid
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search PRAME in MalaCards View complete list of genes associated with diseases

Relevant External Links for PRAME

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRAME
genes like me logo Genes that share disorders with PRAME: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRAME Gene

Publications for PRAME Gene

  1. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. (PMID: 9047241) Ikeda H. … Coulie P.G. (Immunity 1997) 2 3 4 22 65
  2. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. (PMID: 16179254) Epping M.T. … Bernards R. (Cell 2005) 3 4 22 65
  3. Identification of genes associated with non-small-cell lung cancer promotion and progression. (PMID: 19473719) Bankovic J. … Tanic N. (Lung Cancer 2010) 3 22 65
  4. Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. (PMID: 18950857) Qin Y. … Huang X. (Leuk. Res. 2009) 3 22 65
  5. Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene. (PMID: 19027161) Gunn S.R. … Robetorye R.S. (Leuk. Res. 2009) 3 22 65

Products for PRAME Gene

Sources for PRAME Gene

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