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Aliases for PRAME Gene

Aliases for PRAME Gene

  • Preferentially Expressed Antigen In Melanoma 2 3
  • MAPE 3 4 6
  • OIP4 3 4 6
  • Preferentially Expressed Antigen Of Melanoma 3 4
  • Cancer/Testis Antigen 130 2 3
  • Opa-Interacting Protein 4 3 4
  • OIP-4 3 4
  • Melanoma Antigen Preferentially Expressed In Tumors 3
  • Opa-Interacting Protein OIP4 3
  • CT130 3

External Ids for PRAME Gene

Previous Symbols for PRAME Gene

  • MAPE

Summaries for PRAME Gene

Entrez Gene Summary for PRAME Gene

  • This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for PRAME Gene

PRAME (Preferentially Expressed Antigen In Melanoma) is a Protein Coding gene. Diseases associated with PRAME include soft tissue sarcoma and acute leukemia. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF20.

UniProtKB/Swiss-Prot for PRAME Gene

  • Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Gene Wiki entry for PRAME Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRAME Gene

Genomics for PRAME Gene

Genomic Location for PRAME Gene

Start:
22,547,701 bp from pter
End:
22,559,361 bp from pter
Size:
11,661 bases
Orientation:
Minus strand

Genomic View for PRAME Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRAME Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRAME Gene

Regulatory Elements for PRAME Gene

Transcription factor binding sites by QIAGEN in the PRAME gene promoter:

Proteins for PRAME Gene

  • Protein details for PRAME Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78395-PRAME_HUMAN
    Recommended name:
    Melanoma antigen preferentially expressed in tumors
    Protein Accession:
    P78395
    Secondary Accessions:
    • B2R6Y7
    • O43481
    • Q8IXN8

    Protein attributes for PRAME Gene

    Size:
    509 amino acids
    Molecular mass:
    57890 Da
    Quaternary structure:
    • Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic acid)-dependent. Interacts with EZH2; required to repress RAR signaling.
    Miscellaneous:
    • Tumor antigen recognized by cytolytic T lymphocytes

neXtProt entry for PRAME Gene

Proteomics data for PRAME Gene at MOPED

Post-translational modifications for PRAME Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys118

No data available for DME Specific Peptides for PRAME Gene

Domains for PRAME Gene

Protein Domains for PRAME Gene

Graphical View of Domain Structure for InterPro Entry

P78395

UniProtKB/Swiss-Prot:

PRAME_HUMAN
Family:
  • Belongs to the PRAME family.:
    • P78395
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.:
    • P78395
genes like me logo Genes that share domains with PRAME: view

No data available for Gene Families for PRAME Gene

Function for PRAME Gene

Molecular function for PRAME Gene

GENATLAS Biochemistry: preferentially expressed antigen in melanoma
UniProtKB/Swiss-Prot Function: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

Gene Ontology (GO) - Molecular Function for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16179254
GO:0042974 retinoic acid receptor binding IDA 16179254
genes like me logo Genes that share ontologies with PRAME: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PRAME Gene

Localization for PRAME Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRAME Gene

Nucleus. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRAME Gene COMPARTMENTS Subcellular localization image for PRAME gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PRAME: view

Pathways for PRAME Gene

SuperPathways for PRAME Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRAME Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0008284 positive regulation of cell proliferation IDA 16179254
GO:0030154 cell differentiation IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with PRAME: view

No data available for Pathways by source for PRAME Gene

Transcripts for PRAME Gene

Unigene Clusters for PRAME Gene

Preferentially expressed antigen in melanoma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRAME Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - -
SP6: - - - - - -
SP7: -
SP8: - -

Relevant External Links for PRAME Gene

GeneLoc Exon Structure for
PRAME
ECgene alternative splicing isoforms for
PRAME

Expression for PRAME Gene

mRNA expression in normal human tissues for PRAME Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRAME Gene

This gene is overexpressed in Testis (43.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRAME Gene

SOURCE GeneReport for Unigene cluster for PRAME Gene Hs.30743

mRNA Expression by UniProt/SwissProt for PRAME Gene

P78395-PRAME_HUMAN
Tissue specificity: Expressed in testis. Detected in samples of kidney, brain and skin.
genes like me logo Genes that share expressions with PRAME: view

Orthologs for PRAME Gene

This gene was present in the common ancestor of mammals.

Orthologs for PRAME Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRAME 35
  • 98.23 (n)
  • 96.07 (a)
PRAME 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
LOC100300040 35
  • 71.49 (n)
  • 65.28 (a)
PRAME 36
  • 62 (a)
OneToMany
PRAME 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PRAME 35
  • 79.36 (n)
  • 69.74 (a)
PRAME 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AV320801 36
  • 32 (a)
OneToMany
Gm15023 36
  • 32 (a)
OneToMany
Gm5128 36
  • 32 (a)
OneToMany
Gm7903 36
  • 32 (a)
OneToMany
Prame 36
  • 34 (a)
OneToMany
Pramel3 36
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PRAME 36
  • 20 (a)
OneToOne
Species with no ortholog for PRAME:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PRAME Gene

ENSEMBL:
Gene Tree for PRAME (if available)
TreeFam:
Gene Tree for PRAME (if available)

Paralogs for PRAME Gene

genes like me logo Genes that share paralogs with PRAME: view

Variants for PRAME Gene

Sequence variations from dbSNP and Humsavar for PRAME Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7104 -- 22,547,880(-) TGGGG(A/G)TAGGC utr-variant-3-prime
rs8405 -- 22,547,848(-) ATGTG(A/C)TCTTT utr-variant-3-prime
rs13604 -- 22,548,070(-) CCTAA(C/T)TAGCT synonymous-codon, reference
rs739463 -- 22,553,878(-) TGCTG(C/T)TTGTG intron-variant
rs1024372 -- 22,548,773(+) TGTAA(A/C)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRAME Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv526328 CNV Gain 19592680
nsv459421 CNV Gain 19166990
nsv817937 CNV Loss 17921354
dgv548n27 CNV Loss 19166990
esv2422480 CNV Deletion 17116639
nsv828977 CNV Loss 20364138
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv550n27 CNV Loss 19166990
dgv38n64 CNV Loss 17921354
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
nsv834149 CNV Loss 17160897
esv1007524 CNV Gain 20482838
dgv39n64 CNV Loss 17921354
dgv555n27 CNV Loss 19166990
dgv557n27 CNV Loss 19166990
dgv558n27 CNV Loss 19166990
nsv819428 CNV Gain 19587683
nsv514963 CNV Complex 21397061
nsv834150 CNV Loss 17160897
nsv459539 CNV Loss 19166990
nsv821694 CNV Loss 15273396
nsv817957 CNV Gain 17921354
nsv915211 CNV Loss 21882294
nsv508727 CNV Insertion 20534489
nsv511072 CNV Complex 20534489
nsv459548 CNV Loss 19166990
dgv4898n71 CNV Loss 21882294
dgv560n27 CNV Loss 19166990
nsv433336 CNV Loss 18776910
dgv4899n71 CNV Loss 21882294
nsv469742 CNV Complex 16826518

Relevant External Links for PRAME Gene

HapMap Linkage Disequilibrium report
PRAME

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRAME Gene

Disorders for PRAME Gene

(1) University of Copenhagen DISEASES for PRAME Gene

(14) Novoseek inferred disease relationships for PRAME Gene

Disease -log(P) Hits PubMed IDs
minimal residual disease 72.5 9
melanoma 60.5 17
blast crisis 53.9 2
acute leukemia 53.8 7
myeloid leukemia chronic 52.6 3
genes like me logo Genes that share disorders with PRAME: view

No data available for UniProtKB/Swiss-Prot for PRAME Gene

Publications for PRAME Gene

  1. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. (PMID: 9047241) Ikeda H. … Coulie P.G. (Immunity 1997) 2 3 4 23
  2. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. (PMID: 16179254) Epping M.T. … Bernards R. (Cell 2005) 3 4 23
  3. The immunogenic properties of melanoma-associated antigens recognized by cytotoxic T lymphocytes. (PMID: 9619397) Kirkin A.F. … Zeuthen J. (Exp. Clin. Immunogenet. 1998) 3 23
  4. The tumor-associated antigen PRAME is universally expressed in high-stage neuroblastoma and associated with poor outcome. (PMID: 15240516) Oberthuer A. … Fischer M. (Clin. Cancer Res. 2004) 3 23
  5. Real-time RT-PCR quantification of PRAME gene expression for monitoring minimal residual disease in acute myeloblastic leukaemia. (PMID: 16681423) Tajeddine N. … Gala J.L. (Clin. Chem. Lab. Med. 2006) 3 23

Products for PRAME Gene

Sources for PRAME Gene

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