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PRAME Gene

protein-coding   GIFtS: 56
GCID: GC22M022890

Preferentially Expressed Antigen In Melanoma


(Previous symbol: MAPE)
  See PRAME-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Preferentially Expressed Antigen In Melanoma1 2     Preferentially Expressed Antigen Of Melanoma2 3
MAPE1 2 3 5     OIP-42 3
OIP42 3 5     CT1302
Cancer/Testis Antigen 1301 2     Melanoma Antigen Preferentially Expressed In Tumors2
Opa-Interacting Protein 42 3     Opa-Interacting Protein OIP42

External Ids:    HGNC: 93361   Entrez Gene: 235322   Ensembl: ENSG000001856867   OMIM: 6060215   UniProtKB: P783953   

Export aliases for PRAME gene to outside databases

Previous GC identifers: GC22M019588 GC22M021214 GC22M020673 GC22M005860


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PRAME Gene:
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by
cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar
to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is
also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have
been observed for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PRAME Gene:
PRAME (preferentially expressed antigen in melanoma) is a protein-coding gene. Diseases associated with PRAME include soft tissue sarcoma, and acute leukemia. GO annotations related to this gene include retinoic acid receptor binding. An important paralog of this gene is PRAMEF19.

UniProtKB/Swiss-Prot: PRAME_HUMAN, P78395
Function: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic
acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and
apoptosis

Gene Wiki entry for PRAME Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_187629.1  NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PRAME gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPRAME promoter sequence
   Search Chromatin IP Primers for PRAME

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PRAME


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.22   Ensembl cytogenetic band:  22q11.22   HGNC cytogenetic band: 22q11.22

PRAME Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PRAME gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M022890:  view genomic region     (about GC identifiers)

Start:
22,890,123 bp from pter      End:
22,901,768 bp from pter
Size:
11,646 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PRAME_HUMAN, P78395 (See protein sequence)
Recommended Name: Melanoma antigen preferentially expressed in tumors  
Size: 509 amino acids; 57890 Da
Subunit: Interacts with RARA (via the ligand-binding domain); the interaction is direct and ligand (retinoic
acid)-dependent. Interacts with EZH2; required to repress RAR signaling
Miscellaneous: Tumor antigen recognized by cytolytic T lymphocytes
Secondary accessions: B2R6Y7 O43481 Q8IXN8

Explore the universe of human proteins at neXtProt for PRAME: NX_P78395

Explore proteomics data for PRAME at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys118
  • Modification sites at PhosphoSitePlus

  • See PRAME Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_006106.1  NP_996836.1  NP_996837.1  NP_996838.1  NP_996839.1  

    ENSEMBL proteins: 
     ENSP00000381728   ENSP00000384343   ENSP00000385198   ENSP00000407320   ENSP00000407121  
     ENSP00000412318   ENSP00000384058   ENSP00000399816   ENSP00000385091   ENSP00000445675  
     ENSP00000381726   ENSP00000445097   ENSP00000407342  

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    Cloud-Clone Corp. Proteins for PRAME

     
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    antibodies-online proteins for PRAME (6 products) 

     
    antibodies-online peptides for PRAME

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026292 PRAME/Leu_rich_rep-con_p14
     IPR026271 PRAME_family

    Graphical View of Domain Structure for InterPro Entry P78395

    ProtoNet protein and cluster: P78395

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: PRAME_HUMAN, P78395
    Similarity: Belongs to the PRAME family
    Similarity: Contains 4 LRR (leucine-rich) repeats


    Find genes that share domains with PRAME           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRAME_HUMAN, P78395
    Function: Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic
    acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and
    apoptosis

         Genatlas biochemistry entry for PRAME:
    preferentially expressed antigen in melanoma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16179254
    GO:0042974retinoic acid receptor binding IDA16179254
         
    Find genes that share ontologies with PRAME           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PRAME

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PRAME


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PRAME_HUMAN, P78395: Nucleus (Probable). Cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus4
    cytosol2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with PRAME           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PRAME
    Interactions:

        Search GeneGlobe Interaction Network for PRAME

    Selected Interacting proteins for PRAME (P783951, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206342P498421, 2, 3EBI-348325,EBI-347581 MINT-62760 MINT-62684 MINT-62586 I2D: score=5 
    ENSG00000226033P498421, 2, 3EBI-348325,EBI-347581 MINT-62760 MINT-62684 MINT-62586 I2D: score=5 
    ENSG00000226257P498421, 2, 3EBI-348325,EBI-347581 MINT-62760 MINT-62684 MINT-62586 I2D: score=5 
    ENSG00000234947P498421, 2, 3EBI-348325,EBI-347581 MINT-62760 MINT-62684 MINT-62586 I2D: score=5 
    ENSG00000236250P498421, 2, 3EBI-348325,EBI-347581 MINT-62760 MINT-62684 MINT-62586 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0008284positive regulation of cell proliferation IDA16179254
    GO:0030154cell differentiation IEA--
    GO:0040008regulation of growth IEA--

    Find genes that share ontologies with PRAME           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PRAME



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PRAME gene (5 alternative transcripts): 
    NM_006115.3  NM_206953.1  NM_206954.1  NM_206955.1  NM_206956.1  

    Unigene Cluster for PRAME:

    Preferentially expressed antigen in melanoma
    Hs.30743  [show with all ESTs]
    Unigene Representative Sequence: BC022008
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398743(uc002zwf.3 uc010gtr.3 uc002zwi.3 uc002zwj.3)
    ENST00000492657(uc002zwk.3) ENST00000405655 ENST00000402697 ENST00000439106
    ENST00000438888 ENST00000420709 ENST00000476336 ENST00000485532 ENST00000406503
    ENST00000442481 ENST00000403441 ENST00000543184 ENST00000398741(uc002zwg.3 uc002zwh.3)
    ENST00000539862(uc011air.2) ENST00000424204
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PRAME
      QuantiFast Probe-based Assays in human, mouse, rat PRAME

    Additional mRNA sequence: 

    AF025440.1 AK129783.1 AK302188.1 AK304593.1 AK312769.1 AK316395.1 BC014074.2 BC022008.1 
    BC039731.1 CR456549.1 U65011.1 

    19 DOTS entries:

    DT.314248  DT.97783168  DT.101964572  DT.40131245  DT.92444168  DT.92444174  DT.100757437  DT.97851491 
    DT.100825285  DT.100825299  DT.120677185  DT.92444178  DT.100825292  DT.91805738  DT.100825297  DT.120677343 
    DT.120677810  DT.120676911  DT.100825293 

    Selected AceView cDNA sequences (see all 330):

    BX393501 BG035204 BM543297 BM473940 AW188723 BQ888797 U65011 BU171247 
    CR604772 AA781195 BC014074 AA861253 BQ070867 AI918664 AI744983 AK129783 
    BG476623 CD244596 BE302527 AA496991 NM_006115 BX363003 BQ424228 BQ427751 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PRAME (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
    SP1:              -     -     -                                   -     -                                       
    SP2:                                      -     -                 -     -                                       
    SP3:                                      -     -     -           -     -                                       
    SP4:              -     -     -           -                       -     -                                       
    SP5:                                      -     -                 -                                             


    ECgene alternative splicing isoforms for PRAME

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PRAME expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAGTTAA
    PRAME Expression
    About this image


    PRAME expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    PRAME Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PRAME Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.30743

    UniProtKB/Swiss-Prot: PRAME_HUMAN, P78395
    Tissue specificity: Expressed in testis. Detected in samples of kidney, brain and skin

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for PRAME (if available)
    TreeFam Gene Tree for PRAME (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PRAME gene
    PRAMEF192  PRAMEF102  PRAMEF32  PRAMEF202  PRAMEF262  PRAMEF182  PRAMEF212  PRAMEF122  
    PRAMEF152  PRAMEF222  PRAMEF42  PRAMEF22  PRAMEF132  PRAMEF92  LRRC14B2  PRAMEF142  
    PRAMEF72  PRAMEF82  ENSG000002398102  PRAMEF172  PRAMEF52  LRRC142  PRAMEF112  PRAMEF162  
    PRAMEF12  PRAMEF62  
    Selected SIMAP similar genes for PRAME using alignment to 8 protein entries:     PRAME_HUMAN (see all proteins) (see all similar genes):
    PRAMEF12    PRAMEF24    PRAMEF7    PRAMEF8    PRAMEF15    PRAMEF26
    PRAMEF9    PRAMEF19    PRAMEF20    PRAMEF21    PRAMEF23    PRAMEF4
    PRAMEF5    PRAMEF6    PRAMEF11    PRAMEF25    PRAMEF3    PRAMEF10

    Find genes that share paralogs with PRAME           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PRAME (see all 308)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs611787611,2
    C,F--22889639(+) ACCTGG/ATGGGA 5 -- ds50011Minor allele frequency- A:0.23EA 120
    rs60026701,2
    C,F,A,H--22889664(+) CCAGAC/AGCTCC 5 -- ds500124Minor allele frequency- A:0.24NS EA NA WA CSA 1704
    rs750578811,2
    C,F--22889705(+) CAGTAC/TGGGAG 5 -- ds50011Minor allele frequency- T:0.01NA 120
    rs738796341,2
    C,F--22889781(+) CCACTG/CGAAAA 5 -- ds50011Minor allele frequency- C:0.50WA 2
    rs1902390471,2
    --22889814(+) CTCAAC/GGGTTT 5 -- ds50010--------
    rs117050591,2
    C,F,H--22889840(+) TGTGAA/GGAACC 5 -- ds50019Minor allele frequency- G:0.05NA EA NS WA 664
    rs59961371,2
    C,F,H--22889902(+) CTGAGG/AATGTA 5 -- ds500122Minor allele frequency- A:0.34EA NS NA WA CSA 2227
    rs1813617381,2
    --22889950(+) AGCAAA/GGAGAT 5 -- ds50010--------
    rs38273051,2
    C,F,H--22889954(+) AGGAGA/GTAACA 5 -- ds500113Minor allele frequency- G:0.05EA NA NS CSA WA 2280
    rs1484544731,2
    --22889969(+) CCCCAA/GAGAGA 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for PRAME (22890123 - 22901768 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PRAME (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422480CNV Deletion17116639
    nsv508727CNV Insertion20534489
    nsv834150CNV Loss17160897
    dgv551n27CNV Loss19166990
    dgv4899n71CNV Loss21882294
    nsv817937CNV Loss17921354
    dgv39n64CNV Loss17921354
    dgv38n64CNV Loss17921354
    dgv550n27CNV Loss19166990
    dgv4898n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606021    OMIM disorders: --

    7 diseases for PRAME:    
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    soft tissue sarcoma    acute leukemia    mantle cell lymphoma    chronic myeloid leukemia
    melanoma    acute promyelocytic leukemia    acute myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for PRAME:
    Leukemia

    Find genes that share disorders with PRAME           About GenesLikeMe

    Selected Novoseek inferred disease relationships for PRAME gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    minimal residual disease 72.5 11 18950857 (2), 11298586 (2), 11943337 (1), 16860864 (1) (see all 7)
    melanoma 60.5 24 9753074 (2), 16707612 (2), 10682862 (2), 16179254 (1) (see all 14)
    blast crisis 53.9 3 17157168 (1), 17382387 (1)
    acute leukemia 53.8 7 16860864 (3), 16044453 (2), 9753074 (1), 12620290 (1)
    myeloid leukemia chronic 52.6 3 17382387 (2), 10682862 (1)
    leukemia 45.1 11 16978861 (2), 11298586 (2), 16681423 (2), 16044453 (1) (see all 8)
    solid tumor 36 3 16044453 (1), 16860864 (1), 18295331 (1)
    tumors 34.3 20 15240516 (3), 18709641 (3), 16044453 (2), 12419593 (2) (see all 11)
    lymphoblastic leukemia acute 27.7 1 12419593 (1)
    cancer 26.1 11 9740504 (2), 10741395 (2), 12620290 (1), 16179254 (1) (see all 8)


    Export disorders for PRAME gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PRAME gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with PRAME)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. (PubMed id 9047241)1, 2, 3, 9 Ikeda H.... Coulie P.G. (Immunity 1997)
    2. The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. (PubMed id 16179254)1, 2, 9 Epping M.T.... Bernards R. (Cell 2005)
    3. PRAME is a membrane and cytoplasmic protein aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma. (PubMed id 16620968)1, 2 Proto-Siqueira R.... Zago M.A. (Leuk. Res. 2006)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 3 Dunham I.... Wright H. (Nature 1999)
    7. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth. (PubMed id 9466265)1, 2 Williams J.M.... Rest R.F. (Mol. Microbiol. 1998)
    8. Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia. (PubMed id 18587578)1, 9 Ortmann C.A....Zeschnigk M. (Ann. Hematol. 2008)
    9. Epigenetic regulation of PRAME gene in chronic myeloid leukemia. (PubMed id 17382387)1, 9 Roman-Gomez J....Torres A. (Leuk. Res. 2007)
    10. Expression patterns of WT1 and PRAME in acute myeloid leukemia patients and their usefulness for monitoring minimal residual disease. (PubMed id 18950857)1, 9 Qin Y....Huang X. (Leuk. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23532 HGNC: 9336 AceView: PRAME Ensembl:ENSG00000185686 euGenes: HUgn23532
    ECgene: PRAME H-InvDB: PRAME

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PRAME Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PRAME Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PRAME gene:
    Search GeneIP for patents involving PRAME

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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